H. Hashimoto

发表

Comparative analyses of the conformational stability of a hyperthermophilic protein and its mesophilic counterpart.

Y. Kai, S. Fujiwara, T. Imanaka, 2001, European journal of biochemistry.

Hyperthermostable protein structure maintained by intra and inter-helix ion-pairs in archaeal O6-methylguanine-DNA methyltransferase.

M Takagi, Y. Kai, S. Fujiwara, 1999, Journal of molecular biology.

Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication*

R. Heath, H. Hashimoto, A. Inoue, 2012, The Journal of Biological Chemistry.

Whole genome association study of rheumatoid arthritis using 27 039 microsatellites.

Gen Tamiya, Tadashi Imanishi, Takashi Gojobori, 2005, Human molecular genetics.

Structure of the RAD9-RAD1-HUS1 checkpoint clamp bound to RHINO sheds light on the other side of the DNA clamp

Y. Ishikawa, H. Hashimoto, A. Hishiki, 2020, Journal of Biological Chemistry.

Structure of the RAD9-RAD1-HUS1 checkpoint clamp bound to RHINO sheds light on the other side of the DNA clamp.

Y. Ishikawa, H. Hashimoto, A. Hishiki, 2019, The Journal of biological chemistry.

The Crystal Structure of the Novel Calcium-binding Protein AtCBL2 from Arabidopsis thaliana*

Mamoru Sato, Akira Nozawa, Hiroshi Sano, 2003, Journal of Biological Chemistry.

Crystal structure of basic 7S globulin, a xyloglucan‐specific endo‐β‐1,4‐glucanase inhibitor protein‐like protein from soybean lacking inhibitory activity against endo‐β‐glucanase

H. Hirano, Toshiyuki Shimizu, H. Hashimoto, 2011, The FEBS journal.

Crystal structure of aldoxime dehydratase and its catalytic mechanism involved in carbon-nitrogen triple-bond synthesis

H. Hashimoto, Y. Naruta, Ken-ichi Oinuma, 2013, Proceedings of the National Academy of Sciences.

Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction.

R. Heath, H. Hashimoto, A. Inoue, 2016, Bioorganic & medicinal chemistry.

Crystallization and preliminary X-ray crystallographic analysis of archaeal O6-methylguanine-DNA methyltransferase.

Y. Kai, S. Fujiwara, T. Imanaka, 1998, Acta crystallographica. Section D, Biological crystallography.

Key residue responsible for catalytic activities in the antibodies elicited against N-methyl mesoporphyrin

M. Yamazaki, H. Tashiro, H. Hashimoto, 2003 .

Mechanistic insights into the activation of Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex.

M. Ikeguchi, Toshiyuki Shimizu, Y. Tsutsui, 2012, Structure.

Structure and Functional Characterization of Vibrio parahaemolyticus Thermostable Direct Hemolysin*

T. Ikegami, T. Yamane, M. Ikeguchi, 2010, The Journal of Biological Chemistry.

Structure and Function of Thermostable Direct Hemolysin (TDH) from Vibrio Parahaemolyticus

T. Yamane, M. Ikeguchi, H. Hashimoto, 2010 .

The first total synthesis of hibarimicinone, a potent v-Src tyrosine kinase inhibitor

H. Hashimoto, T. Fukuda, K. Tatsuta, 2012 .

Enrichment and Characterization of a Trichloroethene-Dechlorinating Consortium Containing Multiple “Dehalococcoides” Strains

K. Takegawa, M. Goto, H. Hashimoto, 2011, Bioscience, biotechnology, and biochemistry.

Catalytic mechanism and endo-to-exo selectivity reversion of an octalin-forming natural Diels–Alderase

K. Houk, H. Hashimoto, Kenji Watanabe, 2021, Nature Catalysis.

Mutational effects on O(6)-methylguanine-DNA methyltransferase from hyperthermophile: contribution of ion-pair network to protein thermostability.

K. Yokota, S. Fujiwara, T. Imanaka, 2004, Journal of biochemistry.

Structural basis for peptide recognition by archaeal oligopeptide permease A

P. Forterre, Y. Ishikawa, H. Hashimoto, 2022, Proteins.

Structural Characterization of Calcineurin B Homologous Protein 1*

Y. Naoe, Toshiyuki Shimizu, H. Hashimoto, 2005, Journal of Biological Chemistry.

Enzymatic one-step ring contraction for quinolone biosynthesis

K. Houk, H. Hashimoto, Kenji Watanabe, 2018, Nature Communications.

Crystallization and preliminary X-ray crystallographic studies of transportin 1 in complex with nucleocytoplasmic shuttling and nuclear localization fragments.

Toshiyuki Shimizu, H. Hashimoto, M. Yamada, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structural basis of HEAT-kleisin interactions in the human condensin I subcomplex

T. Hirano, H. Hashimoto, K. Kinoshita, 2018, bioRxiv.

Identification of amine acceptor protein substrates of transglutaminase in liver extracts: use of 5-(biotinamido) pentylamine as a probe.

H. Hashimoto, K. Ikura, N. Kawabata, 1998, Archives of biochemistry and biophysics.

Conserved aromatic and basic amino acid residues in the pore region of Caenorhabditis elegans spastin play critical roles in microtubule severing

T. Ogura, H. Hashimoto, M. Esaki, 2009, Genes to cells : devoted to molecular & cellular mechanisms.

Structural basis for the molecular interactions in DNA damage tolerances

H. Hashimoto, A. Hishiki, K. Hara, 2017, Biophysics and physicobiology.

Crystallization and X-ray diffraction analysis of the ternary complex of the C-terminal domain of human REV1 in complex with REV7 bound to a REV3 fragment involved in translesion DNA synthesis.

Toshiyuki Shimizu, H. Hashimoto, Mamoru Sato, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Purification, crystallization and initial X-ray diffraction study of human REV7 in complex with a REV3 fragment

Hashimoto, S. Akashi, Toshiyuki Shimizu, 2009 .

Crystallization and preliminary X-ray crystallographic analysis of human peptidylarginine deiminase V.

Toshiyuki Shimizu, H. Hashimoto, M. Yamada, 2003, Acta Crystallographica Section D: Biological Crystallography.

Structural basis of HEAT‐kleisin interactions in the human condensin I subcomplex

T. Hirano, H. Hashimoto, K. Kinoshita, 2019, EMBO reports.

Purification, crystallization and X-ray diffraction study of extracellular dermal glycoprotein from carrot and the inhibition complex that it forms with an endo-β-glucanase from Aspergillus aculeatus.

H. Hirano, Toshiyuki Shimizu, H. Hashimoto, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structure of the HLTF HIRAN domain and its functional implications in regression of a stalled replication fork.

H. Hashimoto, A. Hishiki, Mamoru Sato, 2020, Acta crystallographica. Section D, Structural biology.

Crystallographic study of a novel DNA-binding domain of human HLTF involved in the template-switching pathway to avoid the replication arrest caused by DNA damage.

H. Hashimoto, H. Yokoyama, A. Hishiki, 2015, Acta crystallographica. Section F, Structural biology communications.

Crystallographic characterization of the N-terminal domain of a plant NADPH oxidase.

K. Shimamoto, Toshiyuki Shimizu, C. Kojima, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallographic study of G178S mutant of human proliferating cell nuclear antigen.

Toshiyuki Shimizu, H. Hashimoto, H. Ohmori, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallization and preliminary X-ray crystallographic analysis of rat calcineurin B homologous protein 1.

Y. Naoe, Toshiyuki Shimizu, H. Hashimoto, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallization and preliminary X-ray characterization of a novel calcium-binding protein AtCBL2 from Arabidopsis thaliana.

Toshiyuki Shimizu, H. Hashimoto, H. Sano, 2003, Acta crystallographica. Section D, Biological crystallography.

Synthesis of 2,6-dialkoxylphenyllanthanoid complexes and their polymerization catalysis

Y. Kai, H. Hashimoto, H. Yasuda, 1998 .

Synthesis and Olefin Polymerization Catalysis of New Divalent Samarium Complexes with Bridging Bis(cyclopentadienyl) Ligands

Y. Kai, H. Hashimoto, H. Yasuda, 1998 .

Integrated Structural Biology in Combination with SAXS Analysis for Biological Macromolecules

H. Hashimoto, T. Oda, 2014 .

Crystal structure of intein homing endonuclease II encoded in DNA polymerase gene from hyperthermophilic archaeon Thermococcus kodakaraensis strain KOD1

Y. Kai, Hitomi Takahashi, S. Fujiwara, 2006, Proteins.

Initial crystallographic study of human PCNA in complex with a peptide containing the noncanonical PIP-box sequence of human DNA polymerase iota.

Toshiyuki Shimizu, H. Hashimoto, H. Ohmori, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Regulation of HLTF-mediated PCNA polyubiquitination by RFC and PCNA monoubiquitination levels determines choice of damage tolerance pathway

H. Hashimoto, C. Masutani, A. Hishiki, 2018, Nucleic acids research.

Crystal Engineering of Stacked Aromatic Columns. Three-Dimensional Control of the Alignment of Orthogonal Aromatic Triads and Guest Quinones via Self-Assembly of Hydrogen-Bonded Networks

Y. Kai, H. Hashimoto, H. Masuda, 1996 .

Specialized Flavoprotein Promotes Sulfur Migration and Spiroaminal Formation in Aspirochlorine Biosynthesis.

H. Hashimoto, Kenji Watanabe, Michio Sato, 2020, Journal of the American Chemical Society.

Syntheses, Structures and Solution Dynamics of Anionic 5-Coordinate Pt(II) Complexes with Halide

Y. Kai, H. Hashimoto, N. Kanehisa, 1998 .

Substituent Effects on the Second Hyperpolarizability of Thioxanthen–9–one and Its Derivatives

H. Hashimoto, N. Kambe, K. Ohta, 1996 .

An established hybridoma clone producing a monoclonal antibody against Vibrio anguillarum.

H. Hashimoto, K. Hayashi, H. Mori, 1997, Bioscience, biotechnology, and biochemistry.

Purification, crystallization and initial X-ray diffraction study of the zinc-finger domain of zebrafish Nanos.

Toshiyuki Shimizu, H. Hashimoto, Keishi Nakamura, 2009, Acta crystallographica. Section F, Structural biology and crystallization communications.

Regioselective effect of zwitterionic DNA substitutions on DNA alkylation: evidence for a strong side chain orientational preference.

H. Hashimoto, C. Switzer, B. Gold, 1997, Biochemistry.

Crystal structure of DNA polymerase from hyperthermophilic archaeon Pyrococcus kodakaraensis KOD1.

Y. Kai, S. Fujiwara, T. Imanaka, 2001, Journal of molecular biology.

Fission Yeast Swi5-Sfr1 Protein Complex, an Activator of Rad51 Recombinase, Forms an Extremely Elongated Dogleg-shaped Structure

M. Ikeguchi, S. Akashi, Toshiyuki Shimizu, 2011, The Journal of Biological Chemistry.

Intrinsic dynamics of restriction endonuclease EcoO109I studied by molecular dynamics simulations and X-ray scattering data analysis.

Mamoru Sato, Mitsunori Ikeguchi, Tomotaka Oroguchi, 2009, Biophysical journal.

Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis.

H. Noguchi, H. Hashimoto, Kenji Watanabe, 2016, Angewandte Chemie.

Structural mechanism for coordination of proofreading and polymerase activities in archaeal DNA polymerases.

Y. Kai, T. Imanaka, H. Hashimoto, 2005, Journal of molecular biology.

Critical Roles of TRAF2 and TRAF5 in Tumor Necrosis Factor-induced NF-κB Activation and Protection from Cell Death*

T. Mak, W. Yeh, H. Nakano, 2001, The Journal of Biological Chemistry.

Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP).

Y. Ishikawa, H. Hashimoto, H. Yokoyama, 2017, The Journal of biological chemistry.

A Missense Mutation in Rev7 Disrupts Formation of Polζ, Impairing Mouse Development and Repair of Genotoxic Agent-induced DNA Lesions*

H. Yamanishi, K. Abe, H. Hashimoto, 2013, The Journal of Biological Chemistry.

Structure of the N-terminal Regulatory Domain of a Plant NADPH Oxidase and Its Functional Implications*

K. Shimamoto, S. Akashi, Toshiyuki Shimizu, 2009, The Journal of Biological Chemistry.

Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance*

Toshiyuki Shimizu, H. Hashimoto, H. Yokoyama, 2015, The Journal of Biological Chemistry.

Structural Basis for Matrix Metalloproteinase-2 (MMP-2)-selective Inhibitory Action of β-Amyloid Precursor Protein-derived Inhibitor*

H. Hashimoto, K. Miyazaki, Mamoru Sato, 2011, The Journal of Biological Chemistry.

Structural basis of recruitment of DNA polymerase ζ by interaction between REV1 and REV7 proteins.

Toshiyuki Shimizu, H. Hashimoto, Mamoru Sato, 2012, The Journal of biological chemistry.

Structural basis for inhibition of xyloglucan-specific endo-β-1,4-glucanase (XEG) by XEG-protein inhibitor.

H. Hirano, Toshiyuki Shimizu, H. Hashimoto, 2012, The Journal of biological chemistry.

Structural basis for Ca2+-induced activation of human PAD4

Toshiyuki Shimizu, H. Hashimoto, M. Yamada, 2004, Nature Structural &Molecular Biology.

REV7 in Cancer Biology and Management

Y. Murakumo, H. Hashimoto, Takuya Kato, 2023, Cancers.

Crystal Structure of Human REV7 in Complex with a Human REV3 Fragment and Structural Implication of the Interaction between DNA Polymerase ζ and REV1*

Y. Murakumo, S. Akashi, Toshiyuki Shimizu, 2010, The Journal of Biological Chemistry.

En bloc transfer of polyubiquitin chains to PCNA in vitro is mediated by two different human E2–E3 pairs

H. Kawai, Miki Suzuki, K. Kamiya, 2012, Nucleic acids research.

The crystal structure of plant-specific calcium-binding protein AtCBL2 in complex with the regulatory domain of AtCIPK14.

Toshiyuki Shimizu, H. Hashimoto, N. Koizumi, 2008, Journal of molecular biology.

Structure of proliferating cell nuclear antigen (PCNA) bound to an APIM peptide reveals the universality of PCNA interaction.

Y. Ishikawa, H. Hashimoto, H. Yokoyama, 2018, Acta crystallographica. Section F, Structural biology communications.

Sequence analysis of a pea comb locus on chicken chromosome 1.

H. Hashimoto, S. Sato, E. Kobayashi, 2010, Animal genetics.

The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors.

Yuan Luo, A. Chumanevich, L. Hofseth, 2011, Journal of medicinal chemistry.

Length variation of CAG/CAA triplet repeats in 50 genes among 16 inbred mouse strains.

Tsuyoshi Koide, T. Gojobori, T. Imanishi, 2005, Gene.

Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4.

Toshiyuki Shimizu, H. Hashimoto, M. Yamada, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Periodate-treated, non-anticoagulant heparin-carrying polystyrene (NAC-HCPS) affects angiogenesis and inhibits subcutaneous induced tumour growth and metastasis to the lung

H. Hashimoto, T. Maehara, M. Ishihara, 2002, British Journal of Cancer.

Structure of HIRAN domain of human HLTF bound to duplex DNA provides structural basis for DNA unwinding to initiate replication fork regression.

H. Hashimoto, A. Hishiki, Mamoru Sato, 2020, Journal of biochemistry.

Structural basis for substrate recognition and dissociation by human transportin 1.

N. Imamoto, Toshiyuki Shimizu, H. Hashimoto, 2007, Molecular cell.

Relationship between heat-induced fibrillogenicity and hemolytic activity of thermostable direct hemolysin and a related hemolysin of Vibrio parahaemolyticus.

K. Shiraki, H. Hashimoto, T. Honda, 2011, FEMS microbiology letters.

Relationship between heat-induced ¢ brillogenicityand hemolytic activityofthermostabledirect hemolysinanda relatedhemolysinof Vibrio parahaemolyticus

K. Shiraki, H. Hashimoto, T. Honda, 2011 .

Structural Basis for Molecular Interactions in DNA Damage Tolerance

H. Hashimoto, A. Hishiki, K. Hara, 2017 .

Sequence Analysis of 193.4 and 83.9 kbp of Mouse and Chicken Genomic DNAs Containing the Entire Prkdc (DNA-PKcs) Gene1

T. Ohhata, R. Fukumura, H. Hashimoto, 2002, Radiation research.

Expression, purification and crystallization of Swi5 and the Swi5-Sfr1 complex from fission yeast.

M. Ikeguchi, Toshiyuki Shimizu, H. Hashimoto, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

A Small Molecule Inhibitor of Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) Inhibits Repair of Interstrand DNA Cross-link, Enhances DNA Double Strand Break, and Sensitizes Cancer Cells to Cisplatin*

R. Heath, C. Canman, H. Hashimoto, 2014, The Journal of Biological Chemistry.

Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen*

Toshiyuki Shimizu, H. Hashimoto, H. Ohmori, 2009, Journal of Biological Chemistry.

Identification of a novel REV1‐interacting motif necessary for DNA polymerase κ function

C. Vaziri, H. Hashimoto, H. Ohmori, 2009, Genes to cells : devoted to molecular & cellular mechanisms.

Crystal structure of zinc‐finger domain of Nanos and its functional implications

Toshiyuki Shimizu, H. Hashimoto, S. Unzai, 2010, EMBO reports.

Crystallization and preliminary X-ray crystallographic analyses of EcoO109I and its complex with DNA.

Toshiyuki Shimizu, H. Hashimoto, Mamoru Sato, 2004, Acta crystallographica. Section D, Biological crystallography.

Structural and Functional Analyses of a Spiro-Carbon-Forming, Highly Promiscuous Epoxidase from Fungal Natural Product Biosynthesis.

H. Hashimoto, Kenji Watanabe, K. Hara, 2020, Biochemistry.

Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1

K. Wakabayashi, Toshiyuki Shimizu, H. Hashimoto, 2017, The Journal of Biological Chemistry.

Crystallographic study of intein homing endonuclease II encoded in the archaeal DNA polymerase gene.

Y. Kai, S. Fujiwara, T. Imanaka, 2000, Acta crystallographica. Section D, Biological crystallography.

Structural basis of new allosteric inhibition in Kinesin spindle protein Eg5.

Y. Ishikawa, K. Matsuno, H. Hashimoto, 2015, ACS chemical biology.

Development of a DNA aptamer that binds to the complementarity-determining region of therapeutic monoclonal antibody and affinity improvement induced by pH-change for sensitive detection.

K. Ikebukuro, H. Hashimoto, T. Toyo’oka, 2022, Biosensors & bioelectronics.

Crystal structure of human REV 7 in complex with a human REV 3 fragment and structural implication of the interaction between DNA polymerase ζ and REV 1

Y. Murakumo, S. Akashi, Toshiyuki Shimizu, 2010 .

Structural Basis for Novel Interactions Between Human Translesion Synthesis Polymerases and PCNA

Toshiyuki Shimizu, H. Hashimoto, H. Ohmori, 2008 .

Enzymatic one-step ring contraction for quinolone biosynthesis

K. Houk, H. Hashimoto, Kenji Watanabe, 2018, Nature Communications.

Recent structural studies of carbohydrate-binding modules

H. Hashimoto, H. Hashimoto, H. Hashimoto, 2006, Cellular and Molecular Life Sciences CMLS.

Functional and Structural Analyses of trans C-Methyltransferase in Fungal Polyketide Biosynthesis.

H. Hashimoto, Kenji Watanabe, Y. Tsunematsu, 2019, Biochemistry.

Structural and Thermodynamic Basis of the Enhanced Interaction between Kinesin Spindle Protein Eg5 and STLC-type Inhibitors

Y. Ishikawa, H. Hashimoto, A. Asai, 2018, ACS omega.

The 9-1-1 DNA clamp subunit RAD1 forms specific interactions with clamp loader RAD17, revealing functional implications for binding-protein RHINO.

H. Hashimoto, A. Hishiki, E. Ohashi, 2023, The Journal of biological chemistry.

STRUCTURAL STUDIES ON THERMOSTABLE PROTEINS FROM HYPERTHERMOPHILIC ARCHAEON PYROCOCCUS KODAKARAENSIS KOD1

Preface, N. Watanabe, Hitomi Takahashi, 2022 .

Effects of high concentration of salts on the esterase activity and structure of a kiwifruit peptidase, actinidain.

H. Hashimoto, K. Inouye, K. Morimoto, 2006, Journal of Biochemistry (Tokyo).

A novel heterotetrameric structure of the crenarchaeal PCNA2-PCNA3 complex.

H. Hashimoto, S. Miyamoto, M. Tsunoda, 2011, Journal of structural biology.

Intrinsic dynamics of restriction endonuclease EcoO109I studied by molecular dynamics simulations and X-ray scattering data analysis.

M. Ikeguchi, Toshiyuki Shimizu, H. Hashimoto, 2009, Biophysical journal.

ring contraction for

K. Houk, H. Hashimoto, Yi Tang, 2018 .

Inactive dimeric structure of the protease domain of stomatin operon partner protein.

H. Hashimoto, I. Matsui, H. Yokoyama, 2020, Acta crystallographica. Section D, Structural biology.

Structural and Biochemical Characterization of a Cyanobacterium Circadian Clock-modifier Protein*

Mamoru Sato, Toshiyuki Shimizu, Toshiyuki Shimizu, 2007, Journal of Biological Chemistry.