M. Aujay

发表

The complete genome of the hyperthermophilic bacterium Aquifex aeolicus

R. Huber, R. Overbeek, G. Olsen, 1998, Nature.

Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics.

K. Nicolaou, M. Aujay, J. Lyssikatos, 2020, Journal of the American Chemical Society.

Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047).

S. Demo, M. Aujay, T. Muchamuel, 2009, Journal of medicinal chemistry.

Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in Waldenstrom macroglobulinemia.

K. Anderson, S. Demo, M. Aujay, 2010, Blood.

Carfilzomib-Dependent Selective Inhibition of the Chymotrypsin-like Activity of the Proteasome Leads to Antitumor Activity in Waldenstrom's Macroglobulinemia

M. Aujay, A. Roccaro, A. Sacco, 2011, Clinical Cancer Research.

ABBV-011, A Novel, Calicheamicin-Based Antibody–Drug Conjugate, Targets SEZ6 to Eradicate Small Cell Lung Cancer Tumors

W. Wiedemeyer, Zhaomei Zhang, P. Vitorino, 2022, Molecular cancer therapeutics.

Synthesis and Biological Evaluation of Shishijimicin A-Type Linker-Drugs and Antibody-Drug Conjugates.

K. Nicolaou, V. Sisodiya, Qifeng Chen, 2020, Journal of the American Chemical Society.

Streamlined Total Synthesis of Shishijimicin A and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues thereof and Practical Syntheses of PhthNSSMe and Related Sulfenylating Reagents.

K. Nicolaou, M. Aujay, Christina Lee, 2018, Journal of the American Chemical Society.

Synergistic effects of proteasome inhibitor carfilzomib in combination with tyrosine kinase inhibitors in imatinib-sensitive and -resistant chronic myeloid leukemia models

J. Melo, T. Holyoake, M. Aujay, 2014, Oncogenesis.

Cancer Therapy: Preclinical Carfilzomib-Dependent Selective Inhibition of the Chymotrypsin-like Activity of the Proteasome Leads to Antitumor Activity in Waldenstrom's Macroglobulinemia

M. Aujay, A. Roccaro, A. Sacco, 2011 .

PR‐924, a selective inhibitor of the immunoproteasome subunit LMP‐7, blocks multiple myeloma cell growth both in vitro and in vivo

D. Chauhan, N. Raje, M. Aujay, 2011, British journal of haematology.

A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma.

P. Richardson, D. Chauhan, N. Raje, 2010, Blood.

The Selective Proteasome Inhibitor Carfilzomib Is Well Tolerated in Experimental Animals with Dose Intensive Administration

M. Aujay, T. Muchamuel, M. Bennett, 2008 .

Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody-Drug Conjugates.

K. Nicolaou, M. Aujay, D. Vourloumis, 2018, Journal of the American Chemical Society.

Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins.

K. Nicolaou, M. Aujay, D. Vourloumis, 2016, Journal of the American Chemical Society.

Short Total Synthesis of Δ12-Prostaglandin J2 and Related Prostaglandins. Design, Synthesis, and Biological Evaluation of Macrocyclic Δ12-Prostaglandin J2 Analogues.

K. Nicolaou, M. Aujay, S. Kishigami, 2019, The Journal of organic chemistry.

Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues.

K. Nicolaou, M. Aujay, S. Rigol, 2017, Journal of the American Chemical Society.

Synthesis and Biological Investigation of Δ(12)-Prostaglandin J3 (Δ(12)-PGJ3) Analogues and Related Compounds.

K. Nicolaou, M. Aujay, M. Brönstrup, 2016, Journal of the American Chemical Society.

Design, Synthesis, and Biological Investigation of Epothilone B Analogues Featuring Lactone, Lactam, and Carbocyclic Macrocycles, Epoxide, Aziridine, and 1,1-Difluorocyclopropane and Other Fluorine Residues.

K. Nicolaou, M. Aujay, Yogesh G Shelke, 2020, The Journal of organic chemistry.

Stereoselective Synthesis of Trisubstituted Ole fi nic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design , Synthesis , and Biological Evaluation of Potent Antitumor Agents

K. Nicolaou, M. Aujay, E. Hamel, 2017 .

A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions

Samuel A. Williams, O. Foord, M. Aujay, 2017, Science Translational Medicine.

A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo

C. Rudin, W. Travis, P. Massion, 2015, Science Translational Medicine.

Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome.

James B Lorens, E. Suzuki, M. Aujay, 2009, Blood.

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

Khalid W. Kalim, S. Demo, E. Suzuki, 2009, Nature Medicine.

Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome.

S. Demo, M. Aujay, M. Bennett, 2007, Cancer research.

Human Immunodeficiency Virus Type 1 Mutations Selected in Patients Failing Efavirenz Combination Therapy

L. Bacheler, M. Aujay, K. Abremski, 2000, Antimicrobial Agents and Chemotherapy.

Streamlined Symmetrical Total Synthesis of Disorazole B1 and Design, Synthesis, and Biological Investigation of Disorazole Analogues.

Zhaomei Zhang, K. Nicolaou, M. Aujay, 2020, Journal of the American Chemical Society.

Uncialamycin-based antibody–drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect

M. Aujay, M. Pysz, H. Karsunky, 2021, Proceedings of the National Academy of Sciences.

Alkaline phosphatase variation during carfilzomib treatment is associated with best response in multiple myeloma patients

F. Zhan, S. Jagannath, A. Jakubowiak, 2011, European journal of haematology.

Anti-EFNA4 Calicheamicin Conjugates Effectively Target Triple-Negative Breast and Ovarian Tumor-Initiating Cells to Result in Sustained Tumor Regressions

Kathryn Loving, O. Foord, M. Aujay, 2015, Clinical Cancer Research.

Evaluation of PNU-159682 antibody drug conjugates (ADCs).

V. Sisodiya, Samuel A. Williams, M. Aujay, 2020, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis.

K. Nicolaou, B. Nocek, M. Aujay, 2021, The Journal of organic chemistry.

Carfilzomib-Dependent Selective Inhibition of the Chymotrypsin-like Activity of the Proteasome Leads to Antitumor Activity in Waldenstrom's Macroglobulinemia

M. Aujay, A. Roccaro, A. Sacco, 2011, Clinical Cancer Research.

12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents.

M. Aujay, R. Bai, J. Gavrilyuk, 2017, Journal of the American Chemical Society.

K. Nicolaou, M. Aujay, Christina Lee, 2018, Journal of the American Chemical Society.

Synthesis and Biological Investigation of Δ(12)-Prostaglandin J3 (Δ(12)-PGJ3) Analogues and Related Compounds.

K. Nicolaou, M. Aujay, M. Brönstrup, 2016, Journal of the American Chemical Society.

Carfilzomib Exerts Anti-Neoplastic Activity in Waldenstrom Macroglobulinemia.

S. Demo, M. Aujay, A. Roccaro, 2009 .