G. Isaksen

发表

Computation of enzyme cold adaptation

J. Åqvist, B. Brandsdal, G. Isaksen, 2017 .

A comparative study of cold- and warm-adapted Endonucleases A using sequence analyses and molecular dynamics simulations

E. Papaleo, B. Brandsdal, M. Tiberti, 2017, PloS one.

Flexible membrane active antimicrobial tripeptides with stability towards chymotryptic degradation

G. Isaksen, 2010 .

Towards Rational Computational Engineering of Psychrophilic Enzymes

J. Åqvist, B. Brandsdal, G. Isaksen, 2019, Scientific Reports.

Entropy and Enzyme Catalysis.

J. Åqvist, B. Brandsdal, G. Isaksen, 2017, Accounts of chemical research.

Structure and Mechanism of a Cold-Adapted Bacterial Lipase

B. Brandsdal, G. Isaksen, M. Widersten, 2022, Biochemistry.

Unnatural amino acid side chains as S1, S1', and S2' probes yield cationic antimicrobial peptides with stability toward chymotryptic degradation.

B. Brandsdal, G. Isaksen, J. Svenson, 2010, Journal of medicinal chemistry.

Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family

J. Åqvist, M. Selmer, U. Eckhard, 2020, bioRxiv.

Targeting the S1 and S3 subsite of trypsin with unnatural cationic amino acids generates antimicrobial peptides with potential for oral administration.

B. Brandsdal, G. Isaksen, E. Wynendaele, 2012, Journal of medicinal chemistry.

QresFEP: an automated protocol for the free energy calculation of protein mutations in Q.

Johan Åqvist, Willem Jespers, Geir Villy Isaksen, 2019, Journal of chemical theory and computation.

Enzyme surface rigidity tunes the temperature dependence of catalytic rates

Geir Villy Isaksen, Johan Åqvist, Bjørn Olav Brandsdal, 2016, Proceedings of the National Academy of Sciences.

In vitro characterization of human peptide transporter hPEPT1 interactions and passive permeation studies of short cationic antimicrobial peptides.

H. Daniel, G. Isaksen, J. Svenson, 2011, Journal of medicinal chemistry.

Protein Surface Softness Is the Origin of Enzyme Cold-Adaptation of Trypsin

Johan Åqvist, Geir Villy Isaksen, Bjørn Olav Brandsdal, 2014, PLoS Comput. Biol..

Thermodynamics of the Purine Nucleoside Phosphorylase Reaction Revealed by Computer Simulations.

J. Åqvist, B. Brandsdal, G. Isaksen, 2017, Biochemistry.

Computer Simulations Reveal Substrate Specificity of Glycosidic Bond Cleavage in Native and Mutant Human Purine Nucleoside Phosphorylase.

J. Åqvist, B. Brandsdal, G. Isaksen, 2016, Biochemistry.

Biophysical characterization and analysis of a mesophilic chorismate mutase from B. pumilus

B. Brandsdal, G. Isaksen, J. Åqvist, 2024, bioRxiv.