Guangyu Yang

发表

Role of the NC-Loop in Catalytic Activity and Stability in Lipase from Fervidobacterium changbaicum

Binchun Li, Guangyu Yang, Lie Wu, 2012, PloS one.

An Improved Single Cell Ultrahigh Throughput Screening Method Based on In Vitro Compartmentalization

Guangyu Yang, Yan Feng, Fuqiang Ma, 2014, PloS one.

Substrate Engineering Enabling Fluorescence Droplet Entrapment for IVC-FACS-Based Ultrahigh-Throughput Screening.

S. Withers, Guangyu Yang, Yan Feng, 2016, Analytical chemistry.

Efficient molecular evolution to generate enantioselective enzymes using a dual-channel microfluidic droplet screening platform

Y. Yao, K. Kurabayashi, Guangyu Yang, 2018, Nature Communications.

A general and efficient strategy for generating the stable enzymes

S. Withers, Guangyu Yang, Yan Feng, 2016, Scientific Reports.

Fluorescence activated cell sorting as a general ultra-high-throughput screening method for directed evolution of glycosyltransferases.

S. Withers, Guangyu Yang, Yan Feng, 2010, Journal of the American Chemical Society.

One-Pot Enzymatic Synthesis and Biological Evaluation of Ganglioside GM3 Derivatives as Potential Cancer Immunotherapeutics.

Guangyu Yang, F. Jiang, L. Fu, 2022, Journal of medicinal chemistry.

Improved thermostability of creatinase from Alcaligenes Faecalis through non-biased phylogenetic consensus-guided mutagenesis

Maohui Luo, Guangyu Yang, Yan Feng, 2020, Microbial Cell Factories.

Design of Hyperthermophilic Lipase Chimeras by Key Motif‐Directed Recombination

Z. Deng, Binchun Li, Guangyu Yang, 2015, Chembiochem : a European journal of chemical biology.

Enhanced Enzyme Kinetic Stability by Increasing Rigidity within the Active Site*

Guangyu Yang, Yan Feng, Yuan Xie, 2014, The Journal of Biological Chemistry.

A FRET probe for cell-based imaging of ganglioside-processing enzyme activity and high-throughput screening.

S. Withers, Guangyu Yang, Yan Feng, 2015, Angewandte Chemie.

Sequence homolog-based molecular engineering for shifting the enzymatic pH optimum

Maohui Luo, Guangyu Yang, Yan Feng, 2016, Synthetic and systems biotechnology.

Enhancing the Promiscuous Phosphotriesterase Activity of a Thermostable Lactonase (GkaP) for the Efficient Degradation of Organophosphate Pesticides

Haifeng Chen, W. Ye, Guangyu Yang, 2012, Applied and Environmental Microbiology.

Comprehensive characterization of sphingolipid ceramide N-deacylase for the synthesis and fatty acid remodeling of glycosphingolipids

S. Withers, Guangyu Yang, Lie Wu, 2015, Applied Microbiology and Biotechnology.

Improved thermostability of creatinase from Alcaligenes Faecalis through non-biased phylogenetic consensus-guided mutagenesis

Maohui Luo, Guangyu Yang, Yan Feng, 2020, Microbial Cell Factories.

Modulation of the thermostability and substrate specificity of Candida rugosa lipase1 by altering the acyl-binding residue Gly414 at the α-helix-connecting bend.

Guangyu Yang, Yan Feng, Yuan Xie, 2016, Enzyme and microbial technology.

Structure features of GH10 xylanase from Caldicellulosiruptor bescii: implication for its thermophilic adaption and substrate binding preference.

Guangyu Yang, Yan Feng, Yuan Xie, 2016, Acta biochimica et biophysica Sinica.

A novel thermophilic β-glucosidase from Caldicellulosiruptor bescii: Characterization and its synergistic catalysis with other cellulases

Guangyu Yang, Yan Feng, A. Bai, 2013 .

Characterization of a thermostable, specific GH10 xylanase from Caldicellulosiruptor bescii with high catalytic activity

Guangyu Yang, Yan Feng, Yuan Xie, 2015 .

Glycosyltransferases: Mining, engineering and applications in biosynthesis of glycosylated plant natural products

Guangyu Yang, Yan Feng, Xue Bai, 2022, Synthetic and systems biotechnology.

Biosynthesis of plant-derived ginsenoside Rh2 in yeast via repurposing a key promiscuous microbial enzyme.

Qian Liu, Zixin Deng, Xueli Zhang, 2017, Metabolic engineering.

Efficient molecular evolution to generate enantioselective enzymes using a dual-channel microfluidic droplet screening platform

Lap Man Lee, Y. Yao, K. Kurabayashi, 2018, Nature Communications.

Switch of substrate specificity of hyperthermophilic acylaminoacyl peptidase by combination of protein and solvent engineering

Guangyu Yang, Yan Feng, Lie Wu, 2011, Protein & Cell.

A facile method for controlling the reaction equilibrium of sphingolipid ceramide N-deacylase for lyso-glycosphingolipid production[S]

Guangyu Yang, Yan Feng, Yunbin Han, 2015, Journal of Lipid Research.

Glu88 in the non-catalytic domain of acylpeptide hydrolase plays dual roles: charge neutralization for enzymatic activity and formation of salt bridge for thermodynamic stability.

Zuoming Zhang, B. Zheng, Guangyu Yang, 2009, Biochimica et biophysica acta.

Discrimination of Esterase and Peptidase Activities of Acylaminoacyl Peptidase from Hyperthermophilic Aeropyrum pernix K1 by a Single Mutation*

Guangyu Yang, Yan Feng, Yanli Liu, 2006, Journal of Biological Chemistry.

Structural Insights into the Broad Substrate Specificity of a Novel Endoglycoceramidase I Belonging to a New Subfamily of GH5 Glycosidases*

Guangyu Yang, Yan Feng, Yunbin Han, 2017, The Journal of Biological Chemistry.

Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method

S. Withers, Haifeng Chen, Guangyu Yang, 2019, Science Advances.

Redesigning the active site of a carboxyl esterase from the archaeon Archaeoglobus fulgidus to improve sensitivity to organophosphorus compounds

Zuoming Zhang, Yan Feng, Binchun Li, 2012 .

Optimization of cell culture and cell disruption processes to enhance the production of thermophilic cellulase FnCel5A in E.coli using response surface methodology

Guangyu Yang, Yan Feng, S. F. Mohammad, 2019, PloS one.

Consensus design for improved thermostability of lipoxygenase from Anabaena sp. PCC 7120

Chong Zhang, Zhaoxin Lu, Haizhen Zhao, 2018, BMC Biotechnology.

An ultrahigh throughput screening platform based on flow cytometric droplet sorting for mining novel enzymes from metagenomic libraries.

K. Kurabayashi, Guangyu Yang, Fuqiang Ma, 2020, Environmental microbiology.

Ultrahigh-throughput Enzymatic Screening Method Based on Fluorescence-activated Cell Sorting and Its Applications*: Ultrahigh-throughput Enzymatic Screening Method Based on Fluorescence-activated Cell Sorting and Its Applications*

Guangyu Yang, Yan Feng, Fuqiang Ma, 2012 .

Improved thermostability of proteinase K and recognizing the synergistic effect of Rosetta and FoldX approaches.

Maohui Luo, Guangyu Yang, Yan Feng, 2021, Protein engineering, design & selection : PEDS.

Creatinase: Using Increased Entropy to Improve the Activity and Thermostability.

H. Liu, Guangyu Yang, Zhuo Liu, 2023, The journal of physical chemistry. B.

Structure-guided reshaping of the acyl binding pocket of 'TesA thioesterase enhances octanoic acid production in E. coli.

Guangyu Yang, Yan Feng, Tiangang Liu, 2020, Metabolic engineering.

Structure of an Endogalactosylceramidase from Rhodococcus hoagii 103S Reveals the Molecular Basis of its Substrate Specificity.

Guangyu Yang, Yan Feng, Yong Zhang, 2019, Journal of structural biology.

Stepwise Loop Insertion Strategy for Active Site Remodeling to Generate Novel Enzyme Functions.

Haifeng Chen, Guangyu Yang, Yan Feng, 2017, ACS chemical biology.

Design, synthesis and neurite outgrowth activity of novel ganglioside GM1 derivatives by remodeling of the fatty acid moiety.

P. Wang, Guangyu Yang, Yan Feng, 2022, European journal of medicinal chemistry.

Comprehensive characterization of sphingolipid ceramide N-deacylase for the synthesis and fatty acid remodeling of glycosphingolipids

S. Withers, Guangyu Yang, Lie Wu, 2015, Applied Microbiology and Biotechnology.

Growth-coupled high throughput selection for directed enzyme evolution.

Guangyu Yang, Zhengqun Li, Yuting Deng, 2023, Biotechnology advances.

Active Site Loop Conformation Regulates Promiscuous Activity in a Lactonase from Geobacillus kaustophilus HTA426

G. Manco, Haifeng Chen, W. Ye, 2015, PloS one.