H. Tsuge

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Unique Tetrameric Structure of Highly Thermostable Aldolase from Hyperthermophile

H. Sakuraba, T. Ohshima, H. Tsuge, 2005 .

Crystal structures of dye‐decolorizing peroxidase with ascorbic acid and 2,6‐dimethoxyphenol

H. Tsuge, T. Hisabori, Y. Sugano, 2012, FEBS letters.

Identification of 16 novel mutations in the argininosuccinate synthetase gene and genotype–phenotype correlation in 38 classical citrullinemia patients

S. Seneca, H. Mandel, L. de Meirleir, 2003, Human mutation.

Leukotriene A4 hydrolase, a bifunctional enzyme Distinction of leukotriene A4 hydrolase and aminopeptidase activities by site‐directed mutagenesis at Glu‐297

Takao Shimizu, H. Bito, H. Tsuge, 1992, FEBS letters.

Structural Basis for the Kexin-like Serine Protease from Aeromonas sobria as Sepsis-causing Factor*

H. Tsuge, N. Katunuma, K. Okamoto, 2009, The Journal of Biological Chemistry.

Structural Basis of Free Reduced Flavin Generation by Flavin Reductase from Thermus thermophilus HB8*

S. Kuramitsu, H. Tsuge, K. Ishidoh, 2011, The Journal of Biological Chemistry.

Crystal structure and structure-based mutagenesis of actin-specific ADP-ribosylating toxin CPILE-a as novel enterotoxin

H. Tsuge, Y. Kamata, Toru Yoshida, 2017, PloS one.

The catalytic mechanism of dye‐decolorizing peroxidase DyP may require the swinging movement of an aspartic acid residue

H. Tsuge, T. Hisabori, Y. Sugano, 2011, The FEBS journal.

Structural analysis of human glutamine:fructose‐6‐phosphate amidotransferase, a key regulator in type 2 diabetes

H. Tsuge, K. Kondo, Kenji Watanabe, 2009, FEBS letters.

Structure-based design of specific cathepsin inhibitors and their application to protection of bone metastases of cancer cells.

H. Tsuge, N. Katunuma, T. Asao, 2002, Archives of biochemistry and biophysics.

Structure of an archaeal alanine:glyoxylate aminotransferase.

H. Sakuraba, T. Ohshima, H. Tsuge, 2008, Acta crystallographica. Section D, Biological crystallography.

Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo

D. Turk, V. Turk, H. Tsuge, 1999, FEBS letters.

Crystallization and preliminary X-ray diffraction studies of a surface mutant of the middle domain of PB2 from human influenza A (H1N1) virus.

H. Tsuge, Hao Qiu, Toru Yoshida, 2014, Acta crystallographica. Section F, Structural biology communications.

Preparation of Clostridium perfringens binary iota-toxin pore complex for structural analysis using cryo-EM.

H. Tsuge, Tomohito Yamada, 2021, Methods in enzymology.

Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases

H. Tsuge, Toru Yoshida, 2021, Toxins.

Substrate N2 atom recognition mechanism in pierisin family DNA-targeting, guanine-specific ADP-ribosyltransferase ScARP

H. Tsuge, Toru Yoshida, 2018, The Journal of Biological Chemistry.

Cryo-EM structures of the translocational binary toxin complex CDTa-bound CDTb-pore from Clostridioides difficile

H. Tsuge, Takayuki Kato, Toru Yoshida, 2021, Nature Communications.

Crystallization and preliminary X-ray diffraction analysis of glutamate dehydrogenase from an aerobic hyperthermophilic archaeon, Aeropyrum pernix K1.

H. Sakuraba, T. Ohshima, H. Tsuge, 2002, Acta crystallographica. Section D, Biological crystallography.

Crystallization and preliminary X-ray crystallographic analysis of Mirabilis antiviral protein.

N. Xuong, K. Appelt, H. Tsuge, 1992, Journal of molecular biology.

Substrate N 2 atom recognition mechanism in pierisin family DNA-targeting, guanine-specific ADP-ribosyltransferase

H. Tsuge, Toru Yoshida, 2018 .

Structural Basis for Action of the External Chaperone for a Propeptide-deficient Serine Protease from Aeromonas sobria*

M. Tanokura, H. Tsuge, K. Okamoto, 2015, The Journal of Biological Chemistry.

Structure of the Human Cytomegalovirus Protease Catalytic Domain Reveals a Novel Serine Protease Fold and Catalytic Triad

David A. Matthews, Susumu Katoh, D. Matthews, 1996, Cell.

Crystallization and preliminary X-ray crystallographic studies of recombinant human leukotriene A4 hydrolase complexed with bestatin.

M. Furuno, M. Aoki, H. Tsuge, 1994, Journal of molecular biology.

Enteric Toxins of Clostridium perfringens: Beta Toxin, TpeL, Epsilon Toxin and Iota Toxin

H. Tsuge, Keiko Kobayashi, M. Nagahama, 2015 .

Role of Sphingomyelinase in Infectious Diseases Caused by Bacillus cereus

H. Tsuge, S. Ochi, M. Nagahama, 2012, PloS one.

Sequential Aldol Condensation Catalyzed by Hyperthermophilic 2-Deoxy-d-Ribose-5-Phosphate Aldolase

H. Sakuraba, T. Ohshima, H. Tsuge, 2007, Applied and Environmental Microbiology.

The First Crystal Structure of Archaeal Aldolase

Y. Kawarabayasi, H. Sakuraba, T. Ohshima, 2003, The Journal of Biological Chemistry.

Expression and secretion of Mirabilis antiviral protein in Escherichia coli and its inhibition of in vitro eukaryotic and prokaryotic protein synthesis.

K. Akiyama, H. Tsuge, N. Habuka, 1990, The Journal of biological chemistry.

Crystal Structure of the NAD Biosynthetic Enzyme Quinolinate Synthase*

H. Sakuraba, T. Ohshima, H. Tsuge, 2005, Journal of Biological Chemistry.

Nucleotide sequence of a genomic gene encoding tritin, a ribosome-inactivating protein from Triticum aestivum

H. Tsuge, N. Habuka, J. Kataoka, 1993, Plant Molecular Biology.

X-ray structure of a pokeweed antiviral protein, coded by a new genomic clone, at 0.23 nm resolution. A model structure provides a suitable electrostatic field for substrate binding.

H. Tsuge, N. Habuka, J Kataoka, 1994, European journal of biochemistry.

X-ray structure of a pokeweed antiviral protein, coded by a new genomic clone, at 0.23 nm resolution A model structure provides a suitable electrostatic field for substrate binding

H. Tsuge, N. Habuka, E. Inagaki, 1994 .

Improved crystals of the toxic protein MAP by protein engineering towards the host specificity.

N. Xuong, B. Wang, M. Furuno, 1994, Acta crystallographica. Section D, Biological crystallography.

Crystal structure of the YdjC-family protein TTHB029 from Thermus thermophilus HB8: structural relationship with peptidoglycan N-acetylglucosamine deacetylase.

S. Kuramitsu, H. Tsuge, A. Ebihara, 2008, Biochemical and biophysical research communications.

Kiyoshi Fukui-face of the flavin ringsiVAAGL hydrophobic stretch located at the Context-dependent variability of the backbone conformation of the Crystal structure of human D-amino acid oxidase :

H. Tsuge, K. Fukui, M. Pilone, 2006 .

Anabaena sp. DyP‐type peroxidase is a tetramer consisting of two asymmetric dimers

H. Tsuge, T. Hisabori, Y. Sugano, 2016, Proteins.

Cryo-EM structures reveal translocational unfolding in the clostridial binary iota toxin complex

H. Tsuge, K. Mitsuoka, K. Iwasaki, 2020, Nature Structural & Molecular Biology.

Clostridium perfringens Iota-Toxin: Structure and Function

H. Tsuge, Keiko Kobayashi, M. Nagahama, 2009, Toxins.

Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens ι-toxin

H. Tsuge, N. Katunuma, M. Nagahama, 2008, Proceedings of the National Academy of Sciences.

Crystal structure and site-directed mutagenesis of enzymatic components from Clostridium perfringens iota-toxin.

H. Tsuge, N. Katunuma, Y. Sakaguchi, 2003, Journal of molecular biology.

A second novel dye‐linked L‐proline dehydrogenase complex is present in the hyperthermophilic archaeon Pyrococcus horikoshii OT‐3

H. Sakuraba, T. Ohshima, H. Tsuge, 2005, The FEBS journal.

Nucleolin as cell surface receptor for tumor necrosis factor-α inducing protein: a carcinogenic factor of Helicobacter pylori

Tatsuro Watanabe, H. Tsuge, H. Fujiki, 2010, Journal of Cancer Research and Clinical Oncology.

The calcium‐binding property of equine lysozyme

S. Sugai, H. Tsuge, K. Nitta, 1987, FEBS letters.

Cryo-EM structures reveal translocational unfolding in the clostridial binary iota toxin complex

H. Tsuge, K. Mitsuoka, K. Iwasaki, 2020, Nature Structural & Molecular Biology.

Translocational unfolding in clostridial binary iota toxin complex

H. Tsuge, K. Mitsuoka, K. Iwasaki, 2019, bioRxiv.

Comparative Studies of Actin- and Rho-Specific ADP-Ribosylating Toxins: Insight from Structural Biology.

H. Tsuge, Toru Yoshida, W. Toniti, 2016, Current topics in microbiology and immunology.

Conformational plasticity is crucial for C3-RhoA complex formation by ARTT-loop.

Toru Yoshida, H. Tsuge, Toshiharu Tsurumura, 2015, Pathogens and disease.

Reaction Mechanism of Mono-ADP-Ribosyltransferase Based on Structures of the Complex of Enzyme and Substrate Protein.

H. Tsuge, T. Tsurumura, 2015, Current topics in microbiology and immunology.

Arginine ADP-ribosylation mechanism based on structural snapshots of iota-toxin and actin complex

Masataka Oda, H. Tsuge, M. Nagahama, 2012, Proceedings of the National Academy of Sciences.

Crystallization and preliminary X-ray studies of the Ia component of Clostridium perfringens iota toxin complexed with NADPH.

H. Tsuge, N. Katunuma, Y. Sakaguchi, 1999, Journal of structural biology.

Specificities of RNA N-glycosidase activity of Mirabilis antiviral protein variants.

H. Tsuge, N. Habuka, J. Kataoka, 1992, The Journal of biological chemistry.

The first crystal structure of hyperthermostable NAD-dependent glutamate dehydrogenase from Pyrobaculum islandicum.

H. Sakuraba, T. Ohshima, H. Tsuge, 2005, Journal of molecular biology.

Crystal Structure of a Novel FAD-, FMN-, and ATP-containing l-Proline Dehydrogenase Complex from Pyrococcus horikoshii*

H. Sakuraba, T. Ohshima, H. Tsuge, 2005, Journal of Biological Chemistry.

Presence of a Motif Conserved between Helicobacter pylori TNF-α Inducing Protein (Tipα) and Penicillin-Binding Proteins

H. Tsuge, T. Kuzuhara, H. Fujiki, 2005 .

Substrate selectivity of bacterial monoacylglycerol lipase based on crystal structure

H. Tsuge, T. Tsurumura, 2014, Journal of Structural and Functional Genomics.

Structural Basis of the Sphingomyelin Phosphodiesterase Activity in Neutral Sphingomyelinase from Bacillus cereus*

Masashi Miyano, Masataka Oda, Hideo Ago, 2006, Journal of Biological Chemistry.

A myelin sheath protein forming its lattice

H. Tsuge, 2020, The Journal of Biological Chemistry.

Conformational Polymorphism of m7GTP in Crystal Structure of the PB2 Middle Domain from Human Influenza A Virus

H. Tsuge, T. Kuzuhara, D. Hatakeyama, 2013, PloS one.

Structure-based development of cathepsin L inhibitors and therapeutic applications for prevention of cancer metastasis and cancer-induced osteoporosis.

H. Tsuge, N. Katunuma, N Katunuma, 2002, Advances in enzyme regulation.

Human D-amino acid oxidase: an update and review.

H. Tsuge, T. Kawazoe, K. Fukui, 2007, Chemical record.

Crystal structure of human D‐amino acid oxidase: Context‐dependent variability of the backbone conformation of the VAAGL hydrophobic stretch located at the si‐face of the flavin ring

H. Tsuge, T. Kawazoe, K. Fukui, 2006, Protein science : a publication of the Protein Society.

Inhibition mechanism of cathepsin L-specific inhibitors based on the crystal structure of papain-CLIK148 complex.

D. Turk, V. Turk, H. Tsuge, 1999, Biochemical and biophysical research communications.

Structural basis of D-DOPA oxidation by D-amino acid oxidase: alternative pathway for dopamine biosynthesis.

S. Kuramitsu, H. Tsuge, T. Kawazoe, 2007, Biochemical and biophysical research communications.

The carboxy‐terminal tail of Aeromonas sobria serine protease is associated with the chaperone

H. Tsuge, E. Takahashi, K. Okamoto, 2009, Microbiology and immunology.

Comparative study of the stability of the folding intermediates of the calcium-binding lysozymes.

H. Tsuge, H. Iwamoto, K. Nitta, 2009, International journal of peptide and protein research.

Structure of l-aspartate oxidase from the hyperthermophilic archaeon Sulfolobus tokodaii.

H. Sakuraba, T. Ohshima, H. Tsuge, 2008, Biochimica et biophysica acta.

Involvement of the Arg566 residue of Aeromonas sobria serine protease in substrate specificity

H. Tsuge, E. Takahashi, K. Okamoto, 2017, PloS one.

Structural Basis of the Influenza A Virus RNA Polymerase PB2 RNA-binding Domain Containing the Pathogenicity-determinant Lysine 627 Residue*

H. Tsuge, T. Kuzuhara, Noriko Echigo, 2009, Journal of Biological Chemistry.

Structural basis for the Helicobacter pylori-carcinogenic TNF-alpha-inducing protein.

Tatsuro Watanabe, H. Tsuge, T. Kuzuhara, 2009, Biochemical and biophysical research communications.

Crystal structure of the ADP‐dependent glucokinase from Pyrococcus horikoshii at 2.0‐Å resolution: A large conformational change in ADP‐dependent glucokinase

H. Sakuraba, T. Ohshima, H. Tsuge, 2002, Protein science : a publication of the Protein Society.

Dendryol A, B, C, and D, Four New Compounds Produced by a Weed Pathogenic Fungus Dendryphiella sp.

H. Tsuge, H. Ago, T. Fujimori, 1995 .

Rho GTPase Recognition by C3 Exoenzyme Based on C3-RhoA Complex Structure*

H. Tsuge, Toru Yoshida, T. Tsurumura, 2015, The Journal of Biological Chemistry.

Structural basis of Rho GTPase recognition by C 3 exoenzyme 1 Rho GTPase recognition by C 3 exoenzyme based on C 3-RhoA complex structure

H. Tsuge, Toru Yoshida, T. Tsurumura, 2015 .

Crystallographic studies of a calcium binding lysozyme from equine milk at 2.5 A resolution.

S. Sugai, H. Tsuge, K. Nitta, 1992, Journal of biochemistry.

Role of side-edge site of sphingomyelinase from Bacillus cereus.

H. Tsuge, M. Nagahama, M. Oda, 2012, Biochemical and biophysical research communications.

Calcium-binding lysozymes.

S. Sugai, H. Tsuge, K. Nitta, 1988, Biological chemistry Hoppe-Seyler.

A structural study of calcium-binding equine lysozyme by two-dimensional 1H-NMR.

S. Sugai, H. Tsuge, K. Nitta, 1991, Biochimica et biophysica acta.

Structure and stability of Gyuba, a β‐lactoglobulin chimera

H. Tsuge, T. Konuma, M. Ikeguchi, 2011, Protein science : a publication of the Protein Society.

Non‐native α‐helix formation is not necessary for folding of lipocalin: Comparison of burst‐phase folding between tear lipocalin and β‐lactoglobulin

K. Maki, K. Kuwajima, H. Tsuge, 2009, Proteins.

Crystal structure of archaeal highly thermostable L‐aspartate dehydrogenase/NAD/citrate ternary complex

H. Sakuraba, T. Ohshima, H. Tsuge, 2007, The FEBS journal.

Amino‐Acid Residues Involved in the Expression of the Activity of Escherichia coli TolC

H. Tsuge, E. Takahashi, K. Okamoto, 2004, Microbiology and immunology.

Structural elucidation and antiviral activity of cathepsin L inhibitors with carbonyl and epoxide warheads

H. Chapman, D. Turk, W. Hinrichs, 2023, bioRxiv.

Crystallization and preliminary X-ray diffraction analysis of the hyperthermostable NAD-dependent glutamate dehydrogenase from Pyrobaculum islandicum.

H. Sakuraba, T. Ohshima, H. Tsuge, 2004, Acta crystallographica. Section D, Biological crystallography.

Structure of a hyperthermophilic archaeal homing endonuclease, I-Tsp061I: contribution of cross-domain polar networks to thermostability.

N. Nomura, Y. Sako, H. Sakuraba, 2007, Journal of molecular biology.

Crystallization and preliminary X-ray diffraction analysis of homing endonuclease I-Tsp061I.

N. Nomura, Y. Sako, H. Sakuraba, 2004, Acta crystallographica. Section D, Biological crystallography.

Refolding, characterization and crystal structure of (S)-malate dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix.

H. Sakuraba, T. Ohshima, H. Tsuge, 2009, Biochimica et biophysica acta.