H. Rozeboom

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Crystal Structure at 2.3 Å Resolution and Revised Nucleotide Sequence of the Thermostable Cyclodextrin Glycosyltransferase from Thermoanaerobacterium thermosulfurigenes EM1

Lubbert Dijkhuizen, L. Dijkhuizen, R. Knegtel, 1996 .

Data acquisition for tillage energy evaluation.

H. Rozeboom, R. W. Wendte, 1981 .

Crystallographic analysis of the catalytic mechanism of haloalkane dehalogenase

K. H. Kalk, B. Dijkstra, K. Verschueren, 1994, Nature.

Structure and mechanism of soluble quinoprotein glucose dehydrogenase

K. H. Kalk, B. Dijkstra, H. Rozeboom, 1999, The EMBO journal.

University of Groningen Crystal structures of two Bacillus carboxylesterases with different enantioselectivities

M. Nardini, B. Dijkstra, W. Quax, 2013 .

Refined X-ray structures of haloalkane dehalogenase at pH 6.2 and pH 8.2 and implications for the reaction mechanism.

K. H. Kalk, B. Dijkstra, K. Verschueren, 1993, Journal of molecular biology.

Structure of a robust bacterial protein cage and its application as a versatile biocatalytic platform through enzyme encapsulation.

H. Rozeboom, M. Fraaije, L. Franken, 2020, Biochemical and biophysical research communications.

Nucleotide sequence and X-ray structure of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 in a maltose-dependent crystal form.

L. Dijkhuizen, K. H. Kalk, B. Dijkstra, 1994, Journal of molecular biology.

Robust ω-Transaminases by Computational Stabilization of the Subunit Interface

Hein J. Wijma, D. Janssen, H. Wijma, 2020, ACS catalysis.

Crystallization and preliminary X-ray analysis of an enantioselective halohydrin dehalogenase from Agrobacterium radiobacter AD1.

K. H. Kalk, D. Janssen, B. Dijkstra, 2002, Acta crystallographica. Section D, Biological crystallography.

Crystallization and preliminary X‐ray analysis of L‐2‐haloacid dehalogenase from xanthobacter autotrophicus GJ10

I. S. Ridder, J. Kingma, D. Janssen, 1995, Protein science : a publication of the Protein Society.

Crystallization of haloalkane dehalogenase from Xanthobacter autotrophicus GJ10.

J. Kingma, D. Janssen, B. Dijkstra, 1988, Journal of molecular biology.

Peptide C-terminal modification using a computationally stabilized peptide amidase

Hein J. Wijma, B. Feringa, D. Janssen, 2018 .

Crystal Structure of Quinohemoprotein Alcohol Dehydrogenase from Comamonas testosteroni

K. H. Kalk, B. Dijkstra, E. Huizinga, 2002, The Journal of Biological Chemistry.

Structure of Human Chitotriosidase IMPLICATIONS FOR SPECIFIC INHIBITOR DESIGN AND FUNCTION OF MAMMALIAN CHITINASE-LIKE LECTINS*

B. Dijkstra, H. Rozeboom, F. Fusetti, 2002 .

Crystallization and preliminary X-ray analysis of carnein, a serine protease from Ipomoea carnea.

R. Siezen, K. H. Kalk, B. Dijkstra, 2009, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallization of the soluble lytic transglycosylase from Escherichia coli K12.

B. Dijkstra, H. Rozeboom, W. Keck, 1990, Journal of molecular biology.

X-ray structure of epoxide hydrolase from Agrobacterium radiobacter AD1 : An enzyme to detoxify harmful epoxides

I. S. Ridder, M. Nardini, K. H. Kalk, 1999 .

Selecting Better Biocatalysts by Complementing Recoded Bacteria

Clemens Mayer, H. Rozeboom, R. Rubini, 2022, bioRxiv.

Crystallization and preliminary crystallographic analysis of endo-1,4-beta-xylanase I from Aspergillus niger

K. H. Kalk, B. Dijkstra, U. Krengel, 1996 .

Crystal structure of the copper-containing quercetin 2,3-dioxygenase from Aspergillus japonicus.

Tjaard Pijning, K. H. Kalk, B. Dijkstra, 2002, Structure.

Crystal structure of Agaricus bisporus mushroom tyrosinase: identity of the tetramer subunits and interaction with tropolone.

B. Dijkstra, H. Rozeboom, J. Mes, 2011, Biochemistry.

Improved thermostability of bacillus circulans cyclodextrin glycosyltransferase by the introduction of a salt bridge

Lubbert Dijkhuizen, H. Leemhuis, L. Dijkhuizen, 2003, Proteins.

Protein engineering of cyclodextrin glycosyltransferase from Bacillus circulans strain 251

L. Dijkhuizen, R. Knegtel, B. Dijkstra, 1995 .

Unlocking Asymmetric Michael Additions in an Archetypical Class I Aldolase by Directed Evolution

H. Rozeboom, A. Thunnissen, G. Poelarends, 2021, ACS catalysis.

University of Groningen Crystal Structure of α-1,4-Glucan Lyase, a Unique Glycoside Hydrolase Family Member with a Novel Catalytic Mechanism Rozeboom,

K. H. Kalk, B. Dijkstra, H. Rozeboom, 2013 .

University of Groningen Crystal Structure of α-1,4-Glucan Lyase, a Unique Glycoside Hydrolase Family Member with a Novel Catalytic Mechanism Rozeboom,

K. H. Kalk, B. Dijkstra, H. Rozeboom, 2013 .

Novel Catalytic Mechanism Unique Glycoside Hydrolase Family-1 , 4-Glucan Lyase , a α Crystal Structure of Protein Structure and Folding :

K. H. Kalk, B. Dijkstra, H. Rozeboom, 2013 .

X-ray structure of cyclodextrin glycosyltransferase complexed with acarbose. Implications for the catalytic mechanism of glycosidases.

L. Dijkhuizen, K. H. Kalk, B. Dijkstra, 1994, Biochemistry.

The 1.7 A crystal structure of the apo form of the soluble quinoprotein glucose dehydrogenase from Acinetobacter calcoaceticus reveals a novel internal conserved sequence repeat.

K. H. Kalk, B. Dijkstra, H. Rozeboom, 1999, Journal of molecular biology.

Structure of Human Chitotriosidase

D. V. van Aalten, B. Dijkstra, H. Rozeboom, 2002, The Journal of Biological Chemistry.

Engineering reaction and product specificity of cyclodextrin glycosyltransferase from Bacillus circulans strain 251

L. Dijkhuizen, R. Knegtel, K. H. Kalk, 2000 .

Active-site structure of the soluble quinoprotein glucose dehydrogenase complexed with methylhydrazine: a covalent cofactor-inhibitor complex.

B. Dijkstra, H. Rozeboom, A. Oubrie, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Catalytic and structural properties of ATP‐dependent caprolactamase from Pseudomonas jessenii

Hein J. Wijma, Clemens Mayer, D. Janssen, 2020, Proteins.

Metal Dependence of the Xylose Isomerase from Piromyces sp. E2 Explored by Activity Profiling and Protein Crystallography

D. Janssen, H. Rozeboom, H. Dudek, 2017, Biochemistry.

University of Groningen Metal-dependence of xylose isomerase from Piromyces sp. E2 explored by activity profiling and protein crystallography

D. Janssen, H. Rozeboom, H. Dudek, 2017 .

Structure-based directed evolution improves S. cerevisiae growth on xylose by influencing in vivo enzyme performance

D. Janssen, H. Rozeboom, Misun Lee, 2020, Biotechnology for Biofuels.

Crystallization and preliminary X-ray crystallographic analysis of tyrosinase from the mushroom Agaricus bisporus.

B. Dijkstra, H. Rozeboom, C. Boeriu, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Enhancement of the enantioselectivity of carboxylesterase A by structure-based mutagenesis.

B. Dijkstra, W. Quax, H. Rozeboom, 2012, Journal of biotechnology.

Structural and functional characterization of a macrophage migration inhibitory factor homologue from the marine cyanobacterium Prochlorococcus marinus .

W. Quax, H. Rozeboom, A. Thunnissen, 2010, Biochemistry.

Conversion of cyclodextrin glycosyltransferase into a starch hydrolase by directed evolution: the role of alanine 230 in acceptor subsite +1.

H. Leemhuis, L. Dijkhuizen, B. Dijkstra, 2003, Biochemistry.

The Remote Substrate Binding Subsite −6 in Cyclodextrin-glycosyltransferase Controls the Transferase Activity of the Enzyme via an Induced-fit Mechanism*

H. Leemhuis, L. Dijkhuizen, B. Dijkstra, 2002, The Journal of Biological Chemistry.

Site-directed mutations in tyrosine 195 of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 affect activity and product specificity.

L. Dijkhuizen, C. Lawson, B. Dijkstra, 1995, Biochemistry.

Computational Redesign of an ω-Transaminase from Pseudomonas jessenii for Asymmetric Synthesis of Enantiopure Bulky Amines

Hein J. Wijma, D. Janssen, S. Marrink, 2021, ACS catalysis.

Characterization of the starch surface binding site on Bacillus paralicheniformis α-amylase.

D. Janssen, H. Rozeboom, Z. Vujčić, 2020, International journal of biological macromolecules.

Picosecond Fluorescence Dynamics of Tryptophan and 5-Fluorotryptophan in Monellin: Slow Water-Protein Relaxation Unmasked

Jianhua Xu, J. Knutson, H. Rozeboom, 2013 .

Crystallization of hevamine, an enzyme with lysozyme/chitinase activity from Hevea brasiliensis latex.

B. Dijkstra, H. Rozeboom, A. Budiani, 1990, Journal of molecular biology.

Expression and characterization of active site mutants of hevamine, a chitinase from the rubber tree Hevea brasiliensis.

E. Bokma, B. Dijkstra, H. Rozeboom, 2002, European journal of biochemistry.

Design of a substrate-tailored peptiligase variant for the efficient synthesis of thymosin-α1.

Hein J. Wijma, D. Janssen, H. Wijma, 2018, Organic & biomolecular chemistry.

Molecular Packaging of Biocatalysts Using a Robust Protein Cage

H. Rozeboom, M. Fraaije, L. Franken, 2020 .

Use of electron microscopy in the examination of lattice defects in crystals of alcohol oxidase

W. Hol, C. Lawson, B. Dijkstra, 1989, FEBS letters.

University of Groningen Structure and mechanism of a bacterial haloalcohol dehalogenase

K. H. Kalk, D. Janssen, B. Dijkstra, 2017 .

Mutational and structural analysis of an ancestral fungal dye‐decolorizing peroxidase

H. Rozeboom, M. Fraaije, Mohamed H. Habib, 2020, The FEBS journal.

Characterization of a New DyP-Peroxidase from the Alkaliphilic Cellulomonad, Cellulomonas bogoriensis

H. Rozeboom, M. Fraaije, Mohamed H. Habib, 2019, Molecules.

University of Groningen Crystal structure of endo-xylogalacturonan hydrolase from Aspergillus tubingensis

B. Dijkstra, H. Rozeboom, H. Schols, 2017 .

Characterization of Two VAO-Type Flavoprotein Oxidases from Myceliophthora thermophila

Robert J. Floor, H. Rozeboom, M. Fraaije, 2018, Molecules.

Elimination of competing hydrolysis and coupling side reactions of a cyclodextrin glucanotransferase by directed evolution.

H. Leemhuis, R. Kelly, L. Dijkhuizen, 2008, The Biochemical journal.

Discovery of a Xylooligosaccharide Oxidase from Myceliophthora thermophila C1*

J. Visser, H. Rozeboom, M. Fraaije, 2016, The Journal of Biological Chemistry.

Structure of the 70-kDa soluble lytic transglycosylase complexed with bulgecin A. Implications for the enzymatic mechanism.

K. H. Kalk, B. Dijkstra, H. Rozeboom, 1995, Biochemistry.

Doughnut-shaped structure of a bacterial muramidase revealed by X-ray crystallography

K. H. Kalk, B. Dijkstra, H. Rozeboom, 1994, Nature.

Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids

B. Feringa, D. Janssen, W. Quax, 2012, Nature Chemistry.

X-ray structure of bovine pancreatic phospholipase A2 at atomic resolution.

K. H. Kalk, B. Dijkstra, K. Wilson, 2001, Acta crystallographica. Section D, Biological crystallography.

The X-ray Structure of Epoxide Hydrolase from Agrobacterium radiobacter AD1

I. S. Ridder, M. Nardini, K. H. Kalk, 1999, The Journal of Biological Chemistry.

Biochemical properties of a Pseudomonas aminotransferase involved in caprolactam metabolism

D. Janssen, H. Rozeboom, Marleen Otzen, 2019, The FEBS journal.

Crystal structure of haloalkane dehalogenase: an enzyme to detoxify halogenated alkanes.

K. H. Kalk, B. Dijkstra, H. Rozeboom, 1991, The EMBO journal.

Haloalkane dehalogenase from Xanthobacter autotrophicus GJ10 refined at 1.15 A resolution.

I. S. Ridder, B. Dijkstra, H. Rozeboom, 1999, Acta crystallographica. Section D, Biological crystallography.

Structure and mechanism of a bacterial haloalcohol dehalogenase: a new variation of the short‐chain dehydrogenase/reductase fold without an NAD(P)H binding site

K. H. Kalk, D. Janssen, B. Dijkstra, 2003, The EMBO journal.

Kinetic and Structural Properties of a Robust Bacterial L-Amino Acid Oxidase

H. Rozeboom, M. Fraaije, J. Meijer, 2021, Catalysts.

Engineering Thermostability in Artificial Metalloenzymes to Increase Catalytic Activity

D. Janssen, J. Naismith, H. Rozeboom, 2021 .

From thiol-subtilisin to omniligase: Design and structure of a broadly applicable peptide ligase

Hein J. Wijma, D. Janssen, H. Wijma, 2021, Computational and structural biotechnology journal.

Structural and Mutational Characterization of the Catalytic A-module of the Mannuronan C-5-epimerase AlgE4 from Azotobacter vinelandii*

K. H. Kalk, B. Dijkstra, H. Rozeboom, 2008, Journal of Biological Chemistry.

Crystallographic Studies of the Interaction of Cyclodextrin Glycosyltransferase from Bacillus circulans Strain 251 with Natural Substrates and Products (*)

L. Dijkhuizen, R. Knegtel, K. H. Kalk, 1995, The Journal of Biological Chemistry.

Crystal Structures of Intermediates in the Dehalogenation of Haloalkanoates by l-2-Haloacid Dehalogenase*

I. S. Ridder, K. H. Kalk, B. Dijkstra, 1999, The Journal of Biological Chemistry.

Structural Elucidation and Engineering of a Bacterial Carbohydrate Oxidase

V. Guallar, H. Rozeboom, M. Fraaije, 2022, Biochemistry.

Three-dimensional Structure of l-2-Haloacid Dehalogenase from Xanthobacter autotrophicus GJ10 Complexed with the Substrate-analogue Formate*

I. S. Ridder, K. H. Kalk, D. Janssen, 1997, The Journal of Biological Chemistry.

Kinetic analysis and X-ray structure of haloalkane dehalogenase with a modified halide-binding site.

I. S. Ridder, K. H. Kalk, G. H. Krooshof, 1998, Biochemistry.

Crystallization of quinohaemoprotein alcohol dehydrogenase from Comamonas testosteroni: crystals with unique optical properties.

K. H. Kalk, B. Dijkstra, E. Huizinga, 2001, Acta crystallographica. Section D, Biological crystallography.

Picosecond fluorescence dynamics of tryptophan and 5-fluorotryptophan in monellin: slow water-protein relaxation unmasked.

Jianhua Xu, J. Knutson, H. Rozeboom, 2015, The journal of physical chemistry. B.

Versatile Peptide C-Terminal Functionalization via a Computationally Engineered Peptide Amidase

Ben L. Feringa, Hein J. Wijma, Dick B. Janssen, 2016 .

Crystallographic and fluorescence studies of the interaction of haloalkane dehalogenase with halide ions. Studies with halide compounds reveal a halide binding site in the active site.

K. H. Kalk, J. Kingma, D. Janssen, 1993, Biochemistry.

Gene Fusion and Directed Evolution to Break Structural Symmetry and Boost Catalysis by an Oligomeric C−C Bond‐Forming Enzyme

H. Rozeboom, A. Thunnissen, G. Poelarends, 2021, Angewandte Chemie.

55 – Structure Determination of Haloalkane Dehalogenase

K. H. Kalk, B. Dijkstra, H. Rozeboom, 1990 .

Crystal structure of quinone‐dependent alcohol dehydrogenase from Pseudogluconobacter saccharoketogenes. A versatile dehydrogenase oxidizing alcohols and carbohydrates

B. Dijkstra, R. Mikkelsen, H. Rozeboom, 2015, Protein science : a publication of the Protein Society.

Characterization of two bacterial multi-flavinylated proteins harboring multiple covalent flavin cofactors

Hein J. Wijma, H. Wijma, H. Rozeboom, 2023, BBA advances.

The fully conserved Asp residue in conserved sequence region I of the α‐amylase family is crucial for the catalytic site architecture and activity

H. Leemhuis, L. Dijkhuizen, B. Dijkstra, 2003, FEBS letters.

Crystal structure at 2.3 A resolution and revised nucleotide sequence of the thermostable cyclodextrin glycosyltransferase from Thermonanaerobacterium thermosulfurigenes EM1.

L. Dijkhuizen, R. Knegtel, K. H. Kalk, 1996, Journal of molecular biology.

Functional and structural characterization of an unusual cofactor-independent oxygenase.

H. Rozeboom, A. Thunnissen, H. Permentier, 2015, Biochemistry.

Regio- and stereoselective steroid hydroxylation by CYP109A2 from Bacillus megaterium explored by X-ray crystallography and computational modeling.

Hein J. Wijma, D. Janssen, H. Wijma, 2023, The FEBS journal.

Crystal structure at 2.3 A resolution and revised nucleotide sequence of the thermostable cyclodextrin glycosyltransferase from Thermonanaerobacterium thermosulfurigenes EM1.

L. Dijkhuizen, R. Knegtel, K. H. Kalk, 1996, Journal of Molecular Biology.

Biochemical properties of a Pseudomonas aminotransferase involved in caprolactam metabolism

D. Janssen, H. Rozeboom, Marleen Otzen, 2019, The FEBS journal.

Structure and mechanism of a bacterial haloalcohol dehalogenase: a new variation of the short‐chain dehydrogenase/reductase fold without an NAD(P)H binding site

K. H. Kalk, B. Dijkstra, H. Rozeboom, 2003, The EMBO journal.

Crystallographic and kinetic evidence of a collision complex formed during halide import in haloalkane dehalogenase.

I. S. Ridder, K. H. Kalk, B. Dijkstra, 1999, Biochemistry.

STRUCTURE OF L-2-HALOACID DEHALOGENASE FROM XANTHOBACTER AUTOTROPHICUS

I. S. Ridder, K. H. Kalk, B. Dijkstra, 1998 .

Non‐covalent binding of the heavy atom compound [Au(CN)2]− at the halide binding site of haloalkane dehalogenase from Xanthobacter autotrophicus GJ10

K. H. Kalk, B. Dijkstra, H. Rozeboom, 1993, FEBS letters.

Structure elucidation and characterization of patulin synthase, insights into the formation of a fungal mycotoxin

J. Visser, A. Ram, H. Rozeboom, 2023, The FEBS journal.

Structure of the 70-kDa soluble lytic transglycosylase complexed with bulgecin A. Implications for the enzymatic mechanism.

K. H. Kalk, B. Dijkstra, H. Rozeboom, 1995, Biochemistry.

Fixing Flavins: Hijacking a Flavin Transferase for Equipping Flavoproteins with a Covalent Flavin Cofactor

Hein J. Wijma, H. Rozeboom, Yapei Tong, 2023, Journal of the American Chemical Society.

Crystal structure of Agaricus bisporus mushroom tyrosinase: identity of the tetramer subunits and interaction with tropolone.

B. Dijkstra, H. Rozeboom, J. Mes, 2011, Biochemistry.

Crystal Structure of α-1,4-Glucan Lyase, a Unique Glycoside Hydrolase Family Member with a Novel Catalytic Mechanism

K. H. Kalk, B. Dijkstra, H. Rozeboom, 2013, The Journal of Biological Chemistry.

University of Groningen Characterization of a New DyP-Peroxidase from the Alkaliphilic Cellulomonad, Cellulomonas bogoriensis

H. Rozeboom, M. Fraaije, Mohamed H Habib, 2019 .

Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids

B. Feringa, D. Janssen, W. Quax, 2012, Nature Chemistry.

Biochemical, kinetic, and structural characterization of a Bacillus tequilensis nitroreductase.

Hein J. Wijma, H. Rozeboom, G. Poelarends, 2024, The FEBS journal.

Conversion of cyclodextrin glycosyltransferase into a starch hydrolase by directed evolution: the role of alanine 230 in acceptor subsite +1.

H. Leemhuis, L. Dijkhuizen, B. Dijkstra, 2003, Biochemistry.