B. Darimont

发表

2.0 A structure of indole-3-glycerol phosphate synthase from the hyperthermophile Sulfolobus solfataricus: possible determinants of protein stability.

M. Hennig, R. Sterner, K. Kirschner, 1995, Structure.

Small structural changes account for the high thermostability of 1[4Fe-4S] ferredoxin from the hyperthermophilic bacterium Thermotoga maritima.

R. Huber, R. Sterner, B. Darimont, 1996, Structure.

The catalytic mechanism of indole-3-glycerol phosphate synthase: crystal structures of complexes of the enzyme from Sulfolobus solfataricus with substrate analogue, substrate, and product.

M. Hennig, K. Kirschner, J. Jansonius, 2002, Journal of molecular biology.

Novel glucocorticoid receptor coactivator effector mechanisms

B. Darimont, B. Jenkins, C. Pullen, 2001, Trends in Endocrinology & Metabolism.

Mutational analysis of the active site of indoleglycerol phosphate synthase from Escherichia coli

B. Darimont, C. Stehlin, Halina Szadkoski, 1998, Protein science : a publication of the Protein Society.

Optimization of an indazole series of selective estrogen receptor degraders: Tumor regression in a tamoxifen-resistant breast cancer xenograft.

Andiliy G. Lai, B. Darimont, J. Sensintaffar, 2015, Bioorganic & medicinal chemistry letters.

Development of antiandrogen ARN-509 1 ARN-509 : a novel antiandrogen for prostate cancer treatment

E. Stanchina, H. Scher, V. Arora, 2012 .

Finding specificity within a conserved interaction site.

B. Darimont, 2003, Chemistry & biology.

Building transcriptional regulatory complexes: signals and surfaces.

K. Yamamoto, R. Wagner, J. Iñiguez-Lluhí, 1998, Cold Spring Harbor symposia on quantitative biology.

Sequence, assembly and evolution of a primordial ferredoxin from Thermotoga maritima.

R. Sterner, B. Darimont, 1994, The EMBO journal.

Selective estrogen receptor degraders with novel structural motifs induce regression in a tamoxifen-resistant breast cancer xenograft.

Andiliy G. Lai, B. Darimont, J. Sensintaffar, 2019, Bioorganic & medicinal chemistry letters.

Development of anti-androgen ARN-509 1 ARN-509: a novel anti-androgen for prostate cancer treatment

H. Scher, V. Arora, C. Sawyers, 2012 .

An F-domain introduced by alternative splicing regulates activity of the zebrafish thyroid hormone receptor alpha.

M. Haendel, J. Eisen, B. Darimont, 2008, General and comparative endocrinology.

Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress.

G. Hammer, B. Darimont, N. Weigel, 1999, Molecular cell.

The Hsp90 chaperone complex A potential target for cancer therapy?

B. Darimont, 1999, World journal of gastroenterology.

ARN-509: a novel antiandrogen for prostate cancer treatment.

H. Scher, V. Arora, C. Sawyers, 2012, Cancer research.

A clinically relevant androgen receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN-509.

Gang Shao, B. Darimont, J. Sensintaffar, 2013, Cancer discovery.

Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor

K. Yamamoto, M. Garabedian, B. Darimont, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer

K. Walter, Andiliy G. Lai, J. Giltnane, 2016, eLife.

A C-Terminal Inhibitory Domain Controls the Activity of p63 by an Intramolecular Mechanism

A. Yang, F. McKeon, V. Dötsch, 2002, Molecular and Cellular Biology.

Mechanism the Activity of P63 by an Intramolecular a C-terminal Inhibitory Domain Controls

A. Yang, F. McKeon, V. Dötsch, 2002 .

Structure and specificity of nuclear receptor-coactivator interactions.

R J Fletterick, J D Baxter, R. Fletterick, 1998, Genes & development.

Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts.

Andiliy G. Lai, B. Darimont, J. Sensintaffar, 2015, Journal of medicinal chemistry.

A conformational switch in the ligand-binding domain regulates the dependence of the glucocorticoid receptor on Hsp90.

K. Yamamoto, B. Darimont, D. Ricketson, 2007, Journal of molecular biology.

Unliganded and hormone-bound glucocorticoid receptors interact with distinct hydrophobic sites in the Hsp90 C-terminal domain

B. Darimont, D. Ricketson, L. Fang, 2006, Proceedings of the National Academy of Sciences.

Maximizing ER-α Degradation Maximizes Activity in a Tamoxifen-Resistant Breast Cancer Model: Identification of GDC-0927.

Andiliy G. Lai, B. Darimont, J. Sensintaffar, 2018, ACS medicinal chemistry letters.

(Beta alpha)8‐barrel proteins of tryptophan biosynthesis in the hyperthermophile Thermotoga maritima.

R. Sterner, K. Kirschner, W. Liebl, 1995, The EMBO journal.

An NMR-derived model for the solution structure of oxidized Thermotoga maritima 1[Fe4-S4] ferredoxin.

R. Sterner, B. Darimont, H. Sticht, 1996, European journal of biochemistry.

Identification of an Orally Bioavailable Chromene-Based Selective Estrogen Receptor Degrader (SERD) That Demonstrates Robust Activity in a Model of Tamoxifen-Resistant Breast Cancer.

Andiliy G. Lai, B. Darimont, J. Sensintaffar, 2018, Journal of medicinal chemistry.

An Additional Region of Coactivator GRIP1 Required for Interaction with the Hormone-binding Domains of a Subset of Nuclear Receptors*

K. Yamamoto, M. Stallcup, B. Darimont, 1999, The Journal of Biological Chemistry.

The Glucocorticoid Receptor Represses Cyclin D1 by Targeting the Tcf-β-Catenin Complex*

B. Darimont, I. Rogatsky, L. Schwarcz, 2006, Journal of Biological Chemistry.

Abstract 1648: Discovery and evolution of orally bioavailable selective estrogen receptor degraders for ER+ breast cancer: From GDC-0810 to GDC-0927

Jun Liang, A. Daemen, Andiliy G. Lai, 2018, Cancer Chemistry.

Targeted tissue delivery of RNA therapeutics using antibody–oligonucleotide conjugates (AOCs)

Barbora Malecova, B. Darimont, A. Levin, 2023, Nucleic acids research.

A C-Terminal Inhibitory Domain Controls the Activity of p63 by an Intramolecular Mechanism

A. Yang, F. McKeon, V. Dötsch, 2002, Molecular and Cellular Biology.