G. Hardy

发表

Sequence, structure and activity of phosphoglycerate kinase: a possible hinge-bending enzyme

P. Evans, D. Rice, C. Blake, 1979, Nature.

The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate.

G. Hardy, T. Skarzynski, O. Singh, 2001, Bioorganic & medicinal chemistry letters.

Human renin: a new class of inhibitors.

C. Harris, D. Stammers, J. Dann, 1986, Biochemical and biophysical research communications.

Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists.

H. T. Jones, I. McLay, G. Hardy, 2009, Bioorganic & medicinal chemistry letters.

Structural requirements for opioid activity of analogues of the enkephalins

C. Beddell, P. Cuatrecasas, R. Miller, 1977, Proceedings of the Royal Society of London. Series B. Biological Sciences.

Antinociceptive effects of the novel opioid peptide BW443C compared with classical opiates; peripheral versus central actions

G. Hardy, T. Smith, C. Schneider, 1988, British journal of pharmacology.

Nonsteroidal glucocorticoid agonists: tetrahydronaphthalenes with alternative steroidal A-ring mimetics possessing dissociated (transrepression/transactivation) efficacy selectivity.

H. T. Jones, I. McLay, G. Hardy, 2007, Journal of medicinal chemistry.

Synthesis of tetrasubstituted bicyclo[3.2.1]octenes as potential inhibitors of influenza virus sialidase.

G. Hardy, R. Bethell, R. Upton, 1999, Bioorganic & medicinal chemistry letters.

BW A575C, a chemically novel agent with angiotensin converting enzyme inhibitor and β‐adrenoceptor‐blocking properties

G. Hardy, G. Allan, D. Cambridge, 1987, British journal of pharmacology.

Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams.

G. Hardy, D. Belton, T. Skarzynski, 2001, Bioorganic & medicinal chemistry letters.

Efficient synthesis of an α-trifluoromethyl-α-tosyloxymethyl epoxide enabling stepwise double functionalisation to afford CF3-substituted tertiary alcohols

H. T. Jones, G. Hardy, D. Coe, 2008 .

Efficient syntheses of (E)-5-(2-bromovinyl)-2'-deoxy-4'-thiouridine; a nucleoside analogue with potent biological activity.

R. T. Walker, G. Hardy, M. Pietrarelli, 1998, Nucleosides & nucleotides.

Synthesis and anti-herpes virus activity of 2'-deoxy-4'-thiopyrimidine nucleosides.

R. T. Walker, G. Hardy, W. Snowden, 1996, Journal of medicinal chemistry.

Conformation of two 4'-thio-2'-deoxynucleoside analogs studied by 5000-MHz proton NMR spectroscopy and x-ray crystallography.

R. T. Walker, J. Plavec, G. Hardy, 1992 .

Synthesis and Anti‐Herpes Virus Activity of 2′‐Deoxy‐4′‐thiopyrimidine Nucleosides.

R. T. Walker, G. Hardy, W. Snowden, 1996 .

Acyl carbamate directing groups in nucleoside synthesis: Applications in the synthesis of 2′-deoxy-5-ethyl-4′-thiouridine

G. Hardy, M. Robertson, R. Young, 1996 .

β-Anomer selectivity in 2′-deoxynucleoside synthesis: A novel approach using an acyl carbamate directing group

G. Hardy, R. Young, G. Mills, 1994 .

β‐Anomer Selectivity in 2′‐Deoxynucleoside Synthesis: A Novel Approach Using an Acyl Carbamate Directing Group.

G. Hardy, R. Young, G. Mills, 1995 .

Synthesis of A575C, a combined angiotensin converting enzyme inhibitor-beta adrenoceptor antagonist

H. T. Jones, G. Hardy, D. Bull, 1988 .

Acyl Carbamate Directing Groups in Nucleoside Synthesis: Applications in the Synthesis of 2′‐Deoxy‐5‐ethyl‐4′‐thiouridine.

G. Hardy, M. Robertson, R. Young, 1996 .

Preclinical Pharmacology of a Novel Dual Acting Angiotensin Converting Enzyme Inhibitor with β‐Adrenoceptor Blocking Properties

G. Hardy, G. Allan, D. Cambridge, 1988 .

Non-steroidal glucocorticoid agonists: the discovery of aryl pyrazoles as A-ring mimetics.

H. T. Jones, I. McLay, G. Hardy, 2007, Bioorganic & medicinal chemistry letters.

Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151).

Martin R. Johnson, G. Hardy, A. Wonacott, 2002, Journal of medicinal chemistry.

Sulphonium analogues of some piperidine analgesics

P. M. Doyle, G. Hardy, T. W. Smith, 1987 .

Peripherally acting enkephalin analogues. 1. Polar pentapeptides.

G. Hardy, S. Wilkinson, T. Smith, 1988, Journal of Medicinal Chemistry.

Amino-acids and peptides. Part 42. Synthesis of a protected docosa peptide having the sequence of mast-cell degranulating peptide

G. Hardy, R. P. Gregson, Susan Coyle, 1979 .

A hybrid gene to express protein epitopes from both sporozoite and merozoite surface antigens of Plasmodium falciparum

A. Holder, M. Lockyer, G. Hardy, 1988, Parasitology.