S. Mowbray

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X-ray structures of the maltose-maltodextrin-binding protein of the thermoacidophilic bacterium Alicyclobacillus acidocaldarius provide insight into acid stability of proteins.

K. Diederichs, K. Schäfer, U. Magnusson, 2003, Journal of molecular biology.

Reconstitution of the bacterial chemotaxis signal transduction system from purified components.

J. Stock, S. Mowbray, E. G. Ninfa, 1991, The Journal of biological chemistry.

Structure of ribose 5-phosphate isomerase type B from Trypanosoma cruzi, soaked with allose-6-phosphate

S. Mowbray, A. Naworyta, A. L. Stern, 2011 .

Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycle.

Cheryl H Arrowsmith, Steven Beasley, Andrzej Joachimiak, 2003, Structure.

The 2.2 A resolution structure of RpiB/AlsB from Escherichia coli illustrates a new approach to the ribose-5-phosphate isomerase reaction.

A. Edwards, A. Joachimiak, T. Skarina, 2003, Journal of molecular biology.

Mycobacterium tuberculosis ribose-5-phosphate isomerase has a known fold, but a novel active site.

T. A. Jones, T. Bergfors, A. Karlén, 2004, Journal of molecular biology.

Structures of type B ribose 5‐phosphate isomerase from Trypanosoma cruzi shed light on the determinants of sugar specificity in the structural family

S. Mowbray, A. Naworyta, A. L. Stern, 2011, The FEBS journal.

The 1.9 A x-ray structure of a closed unliganded form of the periplasmic glucose/galactose receptor from Salmonella typhimurium.

S. Mowbray, M. Flocco, 1994, The Journal of biological chemistry.

Structure of Aspergillus niger epoxide hydrolase at 1.8 A resolution: implications for the structure and function of the mammalian microsomal class of epoxide hydrolases.

F. Oesch, J. Zou, T. Jones, 2000, Structure.

Cα‐based torsion angles: A simple tool to analyze protein conformational changes

S L Mowbray, S. Mowbray, M. Flocco, 1995, Protein science : a publication of the Protein Society.

Sugar Recognition by a Glucose/Galactose Receptor

Sherry L. Mowbray, S. Mowbray, Johan, 1995, The Journal of Biological Chemistry.

Structures of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Provide New Insights into Catalysis*

Jens Carlsson, T. A. Jones, T Alwyn Jones, 2007, Journal of Biological Chemistry.

Structural analysis of the purine repressor, an Escherichia coli DNA-binding protein.

J. Macdonald, M. Schumacher, R. Brennan, 1993, The Journal of biological chemistry.

The Telltale Structures of Epoxide Hydrolases

F. Oesch, S. Mowbray, M. Arand, 2003, Drug metabolism reviews.

Family 7 cellobiohydrolases from Phanerochaete chrysosporium: crystal structure of the catalytic module of Cel7D (CBH58) at 1.32 A resolution and homology models of the isozymes.

S L Mowbray, J. Ståhlberg, G. Pettersson, 2001, Journal of molecular biology.

X-ray Structures of the Leucine-binding Protein Illustrate Conformational Changes and the Basis of Ligand Specificity*

U. Magnusson, S. Mowbray, L. Luck, 2004, Journal of Biological Chemistry.

Conformational changes of ribose-binding protein and two related repressors are tailored to fit the functional need.

S. Mowbray, A. Björkman, 1999, Journal of molecular biology.

Preliminary x-ray data for the galactose binding protein from Salmonella typhimurium.

G. Petsko, T. Alber, S. Mowbray, 1981, Journal of molecular biology.

Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development

J. Napier, R. Haslam, J. Tanner, 2014, Bioscience reports.

Cel6A, a major exoglucanase from the cellulosome of the anaerobic fungi Piromyces sp. E2 and Piromyces equi.

H. Gilbert, S. Mowbray, H. O. D. op den Camp, 2003, Biochimica et biophysica acta.

An intron-containing glycoside hydrolase family 9 cellulase gene encodes the dominant 90 kDa component of the cellulosome of the anaerobic fungus Piromyces sp. strain E2.

G. Vogels, S. Mowbray, H. O. D. op den Camp, 2002, The Biochemical journal.

Crystal structures of a family 19 chitinase from Brassica juncea show flexibility of binding cleft loops

T. Bergfors, S. Mowbray, M. Chye, 2007, The FEBS journal.

Identification of aminopyrimidine‐sulfonamides as potent modulators of Wag31‐mediated cell elongation in mycobacteria

G. Knott, G. Kéri, S. Cole, 2017, Molecular microbiology.

Conformational changes and ligand recognition of Escherichia coli D-xylose binding protein revealed.

Chankyu Park, S. Mowbray, W. Ubhayasekera, 2010, Journal of molecular biology.

Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB).

A. Karlén, S. Mowbray, M. D. De Rosa, 2017, Bioorganic & medicinal chemistry.

Removal of distal protein–water hydrogen bonds in a plant epoxide hydrolase increases catalytic turnover but decreases thermostability

S. Mowbray, A. Naworyta, M. Widersten, 2008, Protein science : a publication of the Protein Society.

Structure of an atypical epoxide hydrolase from Mycobacterium tuberculosis gives insights into its function.

T. Bergfors, S. Mowbray, T. Unge, 2005, Journal of molecular biology.

Functional analyses of the chitin-binding domains and the catalytic domain of Brassica juncea chitinase BjCHI1

S. Mowbray, M. Chye, K. Zhao, 2004, Plant Molecular Biology.

The introduction of specific sites for heavy metal binding in a crystalline protein.

G. Petsko, S. Mowbray, 1983, The Journal of biological chemistry.

Structure of Escherichia coli ribose-5-phosphate isomerase, RpiA, complexed with arabinose-5-phosphate.

Sherry L. Mowbray, Cheryl H. Arrowsmith, Aled M. Edwards, 2003 .

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors†

A. Karlén, S. Mowbray, M. Larhed, 2012, Journal of medicinal chemistry.

Structural and functional studies of mycobacterial IspD enzymes.

T. Jones, T. Bergfors, S. Mowbray, 2011, Acta crystallographica. Section D, Biological crystallography.

Probing protein-protein interactions. The ribose-binding protein in bacterial transport and chemotaxis.

S. Mowbray, H. Zhang, M. Hermodson, 1995, The Journal of biological chemistry.

Primary sequence determinants responsible for site‐selective dephosphorylation of the PDGF β‐receptor by the receptor‐like protein tyrosine phosphatase DEP‐1

S. Mowbray, U. Engström, A. Östman, 2002, FEBS letters.

Bacterial type I signal peptidase inhibitors - Optimized hits from nature.

A. Karlén, S. Mowbray, Anna Więckowska, 2022, European journal of medicinal chemistry.

Activation of ribokinase by monovalent cations.

S. Mowbray, C. Andersson, Sherry L. Mowbray, 2002, Journal of molecular biology.

Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis

S. Mowbray, M. K. Kathiravan, Luke R. Odell, 2014, Molecules.

Synthesis, biological evaluation and X-ray crystallographic studies of imidazo[1,2-a]pyridine-based Mycobacterium tuberculosis glutamine synthetase inhibitors

D. Muthas, A. Karlén, S. Mowbray, 2012 .

Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery.

Anders Karlén, Mats Larhed, Anneli Nordqvist, 2008, Bioorganic & medicinal chemistry.

Microwave-enhanced alpha-arylation of a protected glycine in water: evaluation of 3-phenylglycine derivatives as inhibitors of the tuberculosis enzyme, glutamine synthetase.

A. Karlén, S. Mowbray, Anneli Nordqvist, 2007, Combinatorial chemistry & high throughput screening.

Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase Inhibitors

A. Karlén, S. Mowbray, Anneli Nordqvist, 2011, The Journal of organic chemistry.

Structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition-state mimic provides functional insights.

S. Mowbray, W. Krajewski, T. Jones, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Planar stacking interactions of arginine and aromatic side-chains in proteins.

S L Mowbray, S. Mowbray, M. Flocco, 1994, Journal of molecular biology.

Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase.

A. Karlén, S. Mowbray, D. Hughes, 2018, European journal of medicinal chemistry.

Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents

A. Karlén, S. Mowbray, M. Files, 2015, ChemistryOpen.

Hinge-bending Motion of d-Allose-binding Protein from Escherichia coli

Sherry L. Mowbray, Chankyu Park, Junsang Ko, 2002, The Journal of Biological Chemistry.

Competitive inhibitors of type B ribose 5-phosphate isomerases: design, synthesis and kinetic evaluation of new D-allose and D-allulose 6-phosphate derivatives.

S. Mowbray, A. Roos, L. Salmon, 2009, Carbohydrate research.

Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase.

Martin Lindh, Anders Karlén, Mats Larhed, 2011, Journal of medicinal chemistry.

Structure of Rhodococcus erythropolis limonene‐1,2‐epoxide hydrolase reveals a novel active site

Franz Oesch, Terese Bergfors, F. Oesch, 2003, The EMBO journal.

Expanding the Catalytic Triad in Epoxide Hydrolases and Related Enzymes

Sherry L. Mowbray, Shina Caroline Lynn Kamerlin, Shina C. L. Kamerlin, 2015, ACS catalysis.

Structure of Escherichia coli ribokinase in complex with ribose and dinucleotide determined to 1.8 A resolution: insights into a new family of kinase structures.

T A Jones, S L Mowbray, J A Sigrell, 1998, Structure.

Ribose and glucose-galactose receptors. Competitors in bacterial chemotaxis.

S. Mowbray, 1992, Journal of molecular biology.

1.7 A X-ray structure of the periplasmic ribose receptor from Escherichia coli.

S. Mowbray, L. B. Cole, L. Cole, 1992, Journal of molecular biology.

D-ribose-5-phosphate isomerase B from Escherichia coli is also a functional D-allose-6-phosphate isomerase, while the Mycobacterium tuberculosis enzyme is not.

Laurent Salmon, S. Mowbray, A. Roos, 2008, Journal of molecular biology.

The Antibacterial Activity of Chlorophyll

S. Mowbray, 1957, British medical journal.

X-ray structure of Candida antarctica lipase A shows a novel lid structure and a likely mode of interfacial activation.

Patrik Johansson, Terese Bergfors, T. Bergfors, 2008, Journal of molecular biology.

Directed evolution of an enantioselective epoxide hydrolase: uncovering the source of enantioselectivity at each evolutionary stage.

Manfred T Reetz, Marco Bocola, Joaquin Sanchis, 2009, Journal of the American Chemical Society.

Structures of Phanerochaete chrysosporium Cel7D in complex with product and inhibitors

J. Ståhlberg, A. Vasella, I. Muñoz, 2005, The FEBS journal.

Structural, biochemical, and in vivo investigations of the threonine synthase from Mycobacterium tuberculosis.

T. Bergfors, S. Mowbray, P. Carroll, 2008, Journal of molecular biology.

Synthesis of 5-deoxy-5-phospho-d-ribonohydroxamic acid: a new competitive and selective inhibitor of type B ribose-5-phosphate isomerase from Mycobacterium tuberculosis

S. Mowbray, A. Roos, L. Salmon, 2005 .

Competitive Inhibitors of Mycobacterium tuberculosis Ribose-5-phosphate Isomerase B Reveal New Information about the Reaction Mechanism*

S. Mowbray, A. Roos, L. Salmon, 2005, Journal of Biological Chemistry.

Purification, characterization, and crystallization of Escherichia coli ribokinase

S. Mowbray, A. Cameron, T. Jones, 1997, Protein science : a publication of the Protein Society.

Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.

C. Supuran, S. Mowbray, F. Carta, 2009, Bioorganic & medicinal chemistry letters.

Structure and Function of Carbonic Anhydrases from Mycobacterium tuberculosis*

T. Bergfors, S. Mowbray, M. Högbom, 2005, Journal of Biological Chemistry.

A missense mutation in ftsZ differentially affects vegetative and developmentally controlled cell division in Streptomyces coelicolor A3(2)

S. Mowbray, K. Flärdh, Nina Grantcharova, 2003, Molecular microbiology.

Zinc ions bind to and inhibit activated protein C

S. Mowbray, T. Zhu, Wei Sun, 2010, Thrombosis and Haemostasis.

DXR inhibition by potent mono- and disubstituted fosmidomycin analogues.

T. Bergfors, A. Karlén, S. Mowbray, 2013, Journal of medicinal chemistry.

Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development

J. Napier, R. Haslam, J. Tanner, 2014, Bioscience reports.

Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.

S. Mowbray, T. Karlberg, R. Collins, 2008, Journal of molecular biology.

Functional Analysis of the glycero-manno-Heptose 7-Phosphate Kinase Domain from the Bifunctional HldE Protein, Which Is Involved in ADP-l-glycero-d-manno-Heptose Biosynthesis

S. Mowbray, M. Valvano, C. Andersson, 2005, Journal of Bacteriology.

Synthesis and In Vitro Biological Evaluation of Quinolinyl Pyrimidines Targeting Type II NADH-Dehydrogenase (NDH-2)

S. Cole, A. Karlén, S. Mowbray, 2022, ACS infectious diseases.

Expression and β-glucan binding properties of Scots pine (Pinus sylvestris L.) antimicrobial protein (Sp-AMP)

S. Mowbray, F. Asiegbu, E. Jaber, 2011, Plant Molecular Biology.

Crystal structures and solution conformations of a dominant-negative mutant of Escherichia coli maltose-binding protein.

S. Mowbray, B. Shilton, H. Shuman, 1996, Journal of molecular biology.

The first crystal structures of a family 19 class IV chitinase: the enzyme from Norway spruce

M. Wiweger, S. Mowbray, R. Rawat, 2009, Plant Molecular Biology.

Chemotaxis receptors: a progress report on structure and function.

M. Sandgren, S. Mowbray, 1998, Journal of structural biology.

Additive and independent responses in a single receptor: Aspartate and maltose stimuli on the tar protein

D. Koshland, S. Mowbray, 1987, Cell.

X-ray structure of peptidyl-prolyl cis-trans isomerase A from Mycobacterium tuberculosis.

S. Mowbray, T. Unge, P. Johansson, 2004, European journal of biochemistry.

The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase

F. Oesch, S. Mowbray, B. Fisslthaler, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and bioactivity of β-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase.

Johan Wouters, Alexander Alex, Tom Coenye, 2015, Journal of medicinal chemistry.

Structure of Aspergillus niger epoxide hydrolase

F. Oesch, J. Zou, T. Jones, 2000 .

Bacterial chemotaxis: a field in motion.

Ann M Stock, S. Mowbray, 1995, Current opinion in structural biology.

The x-ray structure of the periplasmic galactose binding protein from Salmonella typhimurium at 3.0-A resolution.

G. Petsko, S. Mowbray, 1983, The Journal of biological chemistry.

Preliminary X-ray data for the periplasmic ribose receptor from Escherichia coli.

S. Mowbray, M. Mahendroo, L. B. Cole, 1990, Journal of molecular biology.

Periplasmic and Membrane Receptors of Bacterial Chemotaxis

S. Mowbray, 1990 .

Molecular Cloning of a Genomic DNA Encoding Yam Class IV Chitinase

S. Mowbray, W. Ubhayasekera, D. Koga, 2004, Bioscience, biotechnology, and biochemistry.

Structural studies on Mycobacterium tuberculosis DXR in complex with the antibiotic FR-900098.

T. Bergfors, S. Mowbray, T. Unge, 2012, Acta crystallographica. Section D, Biological crystallography.

Targeting an Aromatic Hotspot in Plasmodium falciparum 1‐Deoxy‐d‐xylulose‐5‐phosphate Reductoisomerase with β‐Arylpropyl Analogues of Fosmidomycin

S. van Calenbergh, T. Bergfors, J. Wouters, 2016, ChemMedChem.

Conformational changes of three periplasmic receptors for bacterial chemotaxis and transport: the maltose-, glucose/galactose- and ribose-binding proteins.

S. Mowbray, B. Shilton, M. Flocco, 1996, Journal of molecular biology.

The catalytic module of Cel7D from Phanerochaete chrysosporium as a chiral selector: structural studies of its complex with the beta blocker (R)-propranolol.

J. Ståhlberg, I. Muñoz, S. Mowbray, 2003, Acta crystallographica. Section D, Biological crystallography.

X‐ray structure of potato epoxide hydrolase sheds light on substrate specificity in plant enzymes

L. Elfström, S. Mowbray, C. Andersson, 2006, Protein science : a publication of the Protein Society.

Mutations That Affect Ligand Binding to the Escherichia coli Aspartate Receptor

Malin Björkman, M. Sandgren, S. Mowbray, 2001, The Journal of Biological Chemistry.

Mutations in the aspartate receptor of Escherichia coli which affect aspartate binding.

D E Koshland, S L Mowbray, D. Koshland, 1990, The Journal of biological chemistry.

Functional mapping of the surface of escherichia coli ribose‐binding protein: Mutations that affect chemotaxis and transport

S. Mowbray, M. Hermodson, Huide Zhang, 1992, Protein Science.

Proteolytic fragments identified with domains of the aspartate chemoreceptor.

D. Koshland, S. Mowbray, D. Foster, 1985, The Journal of biological chemistry.

Strange bedfellows: interactions between acidic side-chains in proteins.

S L Mowbray, S. Mowbray, M. Flocco, 1995, Journal of molecular biology.

Multiple open forms of ribose-binding protein trace the path of its conformational change.

S L Mowbray, S. Mowbray, A J Björkman, 1998, Journal of molecular biology.

Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors.

T. Jones, A. Karlén, S. Mowbray, 2009, Journal of molecular biology.

Inhibitory effect of transition metal ions on a recombinant thrombin-like enzyme gloshedobin from Gloydius shedaoensis, in Escherichia coli

Qing Yang, S. Mowbray, J. Janson, 2008 .

The 1.7 A refined X-ray structure of the periplasmic glucose/galactose receptor from Salmonella typhimurium.

J. Zou, S. Mowbray, M. Flocco, 1993, Journal of molecular biology.

Structure of the periplasmic glucose/galactose receptor of Salmonella typhimurium.

S. Mowbray, R. D. Smith, L. B. Cole, 1991, Receptor.

Purification and characterization of the aspartate chemoreceptor.

D. Koshland, S. Mowbray, B. Jap, 1985, The Journal of biological chemistry.

Identical mutations at corresponding positions in two homologous proteins with nonidentical effects.

S. Mowbray, H. Zhang, M. Hermodson, 1994, The Journal of biological chemistry.

Mutations that affect chemotaxis and transport

S. Mowbray, M. Hermodson, R. A. Binnie, 1992 .

Modeling of the structure of the Haemophilus influenzae heme‐binding protein suggests a mode of heme interaction

S. Mowbray, P. Dunten, 1995, Protein science : a publication of the Protein Society.

Crystal structure of the dipeptide binding protein from Escherichia coli involved in active transport and chemotaxis

S. Mowbray, P. Dunten, 1995, Protein science : a publication of the Protein Society.

Crystallization and preliminary X-ray analysis of the periplasmic dipeptide binding protein from Escherichia coli.

S. Mowbray, J. Harris, P. Dunten, 1993, Journal of molecular biology.

Induced fit on sugar binding activates ribokinase.

S. Mowbray, A. Cameron, J. Sigrell, 1999, Journal of molecular biology.

Regulation of RNA synthesis in Escherichia coli during a shift-up transition.

D. Nierlich, S. Mowbray, 1975, Biochimica et Biophysica Acta.

Simple models for the analysis of binding protein‐dependent transport systems

S. Mowbray, B. Shilton, 1995, Protein science : a publication of the Protein Society.

Structure of D-allose binding protein from Escherichia coli bound to D-allose at 1.8 A resolution.

T A Jones, S L Mowbray, B. Chaudhuri, 1999, Journal of molecular biology.

Targeting an Aromatic Hotspot in Plasmodium falciparum 1‐Deoxy‐d‐xylulose‐5‐phosphate Reductoisomerase with β‐Arylpropyl Analogues of Fosmidomycin

T. Jones, T. Bergfors, J. Wouters, 2016, ChemMedChem.

Structures of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase Provide New Insights into Catalysis*

S. Mowbray, Jens Carlsson, T. Unge, 2007, Journal of Biological Chemistry.

Preliminary X-ray data for the ribose binding protein from Salmonella typhimurium.

G. Petsko, S. Mowbray, 1982, Journal of molecular biology.