A. Paiardini

发表

Structural plasticity of thermophilic serine hydroxymethyltransferases

S. Pascarella, F. Bossa, G. Gianese, 2002, Proteins.

Structural Basis of Functional Diversification of the HD-GYP Domain Revealed by the Pseudomonas aeruginosa PA4781 Protein, Which Displays an Unselective Bimetallic Binding Site

A. Paiardini, F. Cutruzzolà, L. Cervoni, 2015, Journal of bacteriology.

A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates

Flavio Keller, Alessandro Paiardini, Roger Panteri, 2006, Brain Research.

Chemogenomics of pyridoxal 5′-phosphate dependent enzymes

S. Pascarella, F. Spyrakis, A. Mozzarelli, 2013, Journal of enzyme inhibition and medicinal chemistry.

From PARP1 to TNKS2 Inhibition: A Structure-Based Approach.

E. Novellino, A. Mai, C. Steegborn, 2020, ACS medicinal chemistry letters.

Type I pyridoxal 5′-phosphate dependent enzymatic domains embedded within multimodular nonribosomal peptide synthetase and polyketide synthase assembly lines

Stefano Pascarella, Alessandro Paiardini, Teresa Milano, 2013, BMC Structural Biology.

Nutrient Sensing and Biofilm Modulation: The Example of L-arginine in Pseudomonas

A. Paiardini, F. Cutruzzolà, A. Paone, 2022, International Journal of Molecular Sciences.

N6-Methyladenosine (m6A): A Promising New Molecular Target in Acute Myeloid Leukemia

A. Fatica, A. Paiardini, Zaira Ianniello, 2019, Front. Oncol..

PHA-680626 Is an Effective Inhibitor of the Interaction between Aurora-A and N-Myc

D. Trisciuoglio, A. Paiardini, R. Di Santo, 2021, International Journal of Molecular Sciences.

Studying GGDEF Domain in the Act: Minimize Conformational Frustration to Prevent Artefacts

A. Paiardini, F. Cutruzzolà, R. Petrelli, 2021, Life.

A Focused Small-Molecule Screen Identifies PHA-680626 as an Amphosteric Inhibitor Disrupting the Interaction between Aurora-A and N-Myc

D. Trisciuoglio, A. Paiardini, R. Di Santo, 2021, bioRxiv.

A novel bacterial l‐arginine sensor controlling c‐di‐GMP levels in Pseudomonas aeruginosa

A. Paiardini, F. Cutruzzolà, A. Paone, 2018, Proteins.

Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex

A. Paiardini, F. Cutruzzolà, R. Montanari, 2020, bioRxiv.

Effect of the Sirtuin Inhibitor MC2494 on RIPK1 Expression

L. Altucci, A. Mai, A. Nebbioso, 2019, Biomedical Journal of Scientific & Technical Research.

How pyridoxal 5′‐phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state

A. Buckle, Mauricio G S Costa, A. Paiardini, 2015, The FEBS journal.

cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state

A. Buckle, Mauricio G S Costa, A. Paiardini, 2015 .

Human wild-type alanine:glyoxylate aminotransferase and its naturally occurring G82E variant: functional properties and physiological implications.

A. Paiardini, M. Bertoldi, R. Montioli, 2007, The Biochemical journal.

Insights into the GTP‐dependent allosteric control of c‐di‐GMP hydrolysis from the crystal structure of PA0575 protein from Pseudomonas aeruginosa

A. Arcovito, A. Paiardini, F. Cutruzzolà, 2018, The FEBS journal.

Investigating the Allosteric Regulation of YfiN from Pseudomonas aeruginosa: Clues from the Structure of the Catalytic Domain

A. Paiardini, F. Cutruzzolà, G. Giardina, 2013, PloS one.

Structural mimicry between SLA/LP and Rickettsia surface antigens as a driver of autoimmune hepatitis: insights from an in silico study

S. Pascarella, A. Paiardini, 2013, Theoretical Biology and Medical Modelling.

Artemisinin Derivatives with Antimelanoma Activity Show Inhibitory Effect against Human DNA Topoisomerase 1.

R. Saladino, A. Paiardini, L. Botta, 2020, ACS medicinal chemistry letters.

C-di-GMP Hydrolysis by Pseudomonas aeruginosa HD-GYP Phosphodiesterases: Analysis of the Reaction Mechanism and Novel Roles for pGpG

A. Paiardini, F. Cutruzzolà, G. Giardina, 2013, PloS one.

Unique substrate specificity of ornithine aminotransferase from Toxoplasma gondii.

A. Paiardini, M. Bertoldi, A. Astegno, 2017, The Biochemical journal.

The phytotoxin fusicoccin differently regulates 14‐3‐3 proteins association to mode III targets

S. Pascarella, A. Paiardini, F. Cutruzzolà, 2014, IUBMB life.

Bacterial Oxidases of the Cytochrome bd Family: Redox Enzymes of Unique Structure, Function and Utility as Drug Targets.

A. Paiardini, R. Poole, D. Hoogewijs, 2020, Antioxidants & redox signaling.

Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis

Cyril F. Reboul, I. Mackay, D. Pérahia, 2014, Proceedings of the National Academy of Sciences.

A Novel Hypothesis on Choroideremia-Manifesting Female Carriers: Could CHM In-Frame Variants Exert a Dominant Negative Effect? A Case Report

I. Bottillo, A. Paiardini, P. Grammatico, 2022, Genes.

The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells

A. Paiardini, F. Cutruzzolà, A. Tramonti, 2018, The FEBS journal.

SARS-CoV-2 Spike Does Not Possess Intrinsic Superantigen-like Inflammatory Activity

Martina Kunkl, Carola Amormino, L. Tuosto, 2022, Cells.

Identification of small molecule inhibitors of the Aurora-A/TPX2 complex

A. Paiardini, P. Lavia, I. A. Asteriti, 2017, Oncotarget.

Mutational analysis and homology modelling of SyrC, the aminoacyltransferase in the biosynthesis of syringomycin.

A. Paiardini, Shi-En Lu, D. Gross, 2007, Biochemical and biophysical research communications.

Alanine racemase from Tolypocladium inflatum: a key PLP-dependent enzyme in cyclosporin biosynthesis and a model of catalytic promiscuity.

R. Florio, A. Paiardini, M. D. di Salvo, 2013, Archives of biochemistry and biophysics.

A novel CDKN2A in-frame deletion associated with pancreatic cancer-melanoma syndrome.

I. Bottillo, A. Paiardini, R. Sestini, 2020, Dermatology online journal.

Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis

A. Paiardini, F. Cutruzzolà, G. Giardina, 2017, Scientific Reports.

Structural adaptation of extreme halophilic proteins through decrease of conserved hydrophobic contact surface

S. Pascarella, A. Paiardini, A. Siglioccolo, 2011, BMC Structural Biology.

In Silico Discovery and In Vitro Validation of Catechol-Containing Sulfonohydrazide Compounds as Potent Inhibitors of the Diguanylate Cyclase PleD

A. Paiardini, F. Cutruzzolà, G. Giardina, 2015, Journal of bacteriology.

Boosting the Full Potential of PyMOL with Structural Biology Plugins

A. Paiardini, Serena Rosignoli, 2022, Biomolecules.

Pyridoxine-5'-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g>A (P.·Arg116gln) mutation.

I. Nogués, R. Guerrini, A. Paiardini, 2017, Molecular genetics and metabolism.

Synthesis and Structure − Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M 1 and M 17 Aminopeptidases from Plasmodium falciparum

J. Dalton, S. McGowan, A. Paiardini, 2013 .

Functional Characterization and Structure-Guided Mutational Analysis of the Transsulfuration Enzyme Cystathionine γ-Lyase from Toxoplasma gondii

A. Paiardini, A. Astegno, G. Janson, 2018, International journal of molecular sciences.

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.

Shailesh N Mistry, S. McGowan, A. Paiardini, 2016, European journal of medicinal chemistry.

l-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subgroup of strictly related enzymes specialized for different functions.

S. Pascarella, F. Bossa, A. Paiardini, 2001, European journal of biochemistry.

Treponema denticola cystalysin exhibits significant alanine racemase activity accompanied by transamination: mechanistic implications.

A. Paiardini, M. Bertoldi, M. D. di Salvo, 2003, The Biochemical journal.

Site-directed Mutagenesis Provides Insight into Racemization and Transamination of Alanine Catalyzed by Treponema denticola Cystalysin*

A. Paiardini, M. Bertoldi, B. Cellini, 2004, Journal of Biological Chemistry.

A Single Center Retrospective Review of Patients from Central Italy Tested for Melanoma Predisposition Genes

I. Bottillo, A. Paiardini, P. Grammatico, 2020, International journal of molecular sciences.

In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed.

F. Bossa, R. Florio, A. Paiardini, 2011, European journal of medicinal chemistry.

On the catalytic mechanism and stereospecificity of Escherichia coli l‐threonine aldolase

A. Paiardini, S. Remesh, M. Safo, 2014, The FEBS journal.

The Archaeal Elongation Factor EF-2 Induces the Release of aIF6 From 50S Ribosomal Subunit

A. Paiardini, P. Londei, D. Benelli, 2021, Frontiers in Microbiology.

PyMod: sequence similarity searches, multiple sequence-structure alignments, and homology modeling within PyMOL

Stefano Pascarella, Francesco Bossa, Alessandro Paiardini, 2012, BMC Bioinformatics.

Intronic Determinants Coordinate Charme lncRNA Nuclear Activity through the Interaction with MATR3 and PTBP1

I. Bozzoni, Tiziana Santini, A. Paiardini, 2020, Cell reports.

Nuclear localisation of Aurora-A: its regulation and significance for Aurora-A functions in cancer

A. Paiardini, G. Guarguaglini, C. Lindon, 2021, Oncogene.

Revisiting the “satisfaction of spatial restraints” approach of MODELLER for protein homology modeling

Gabriele Ausiello, Alessandro Grottesi, Marco Pietrosanto, 2019, bioRxiv.

The novel R347g pathogenic mutation of aromatic amino acid decarboxylase provides additional molecular insights into enzyme catalysis and deficiency.

A. Paiardini, M. Bertoldi, S. Heales, 2016, Biochimica et biophysica acta.

Glucose Metabolism in the Progression of Prostate Cancer

A. Paiardini, F. Cutruzzolà, A. Macone, 2017, Front. Physiol..

A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells

Tianyi Yang, D. Koes, A. Paiardini, 2015, Oncotarget.

Screening and In Vitro Testing of Antifolate Inhibitors of Human Cytosolic Serine Hydroxymethyltransferase

D. Koes, A. Paiardini, F. Cutruzzolà, 2015, ChemMedChem.

SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation

A. Paiardini, M. Marani, F. Cutruzzolà, 2014, Cell Death and Disease.

Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: the heme connection.

A. Paiardini, B. Maras, M. D. di Salvo, 2013, Medical hypotheses.

Molecular analysis of sarcomeric and non-sarcomeric genes in patients with hypertrophic cardiomyopathy.

V. Caputo, A. Pizzuti, I. Bottillo, 2016, Gene.

Rapid Profiling of Disease Alleles Using a Tunable Reporter of Protein Misfolding

Justin D. Vrana, A. Paiardini, C. Tucker, 2012, Genetics.

Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases

Alessandro Paiardini, S. Gianni, A. Paiardini, 2011, Proceedings of the National Academy of Sciences.

The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism

A. Fatica, J. Menéndez, A. Paiardini, 2019, Nucleic acids research.

PyMod 2.0: improvements in protein sequence‐structure analysis and homology modeling within PyMOL

Chengxin Zhang, Giacomo Janson, Alessandro Paiardini, 2016, Bioinform..

Cysteine 180 Is a Redox Sensor Modulating the Activity of Human Pyridoxal 5'-Phosphate Histidine Decarboxylase.

A. Paiardini, A. Grottesi, M. Bertoldi, 2018, Biochemistry.

PyMod 3: a complete suite for structural bioinformatics in PyMOL

Giacomo Janson, Alessandro Paiardini, A. Paiardini, 2020, Bioinform..

Crystal structure of the S187F variant of human liver alanine: Aminotransferase associated with primary hyperoxaluria type I and its functional implications

M. Wilmanns, A. Paiardini, K. Fodor, 2013, Proteins.

Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening

Alessandro Paiardini, Chiara Ruggeri, Sheena McGowan, 2015, PloS one.

When Just One Phosphate Is One Too Many: The Multifaceted Interplay between Myc and Kinases

A. Paiardini, G. Guarguaglini, Elisabetta Rubini, 2023, International journal of molecular sciences.

A truncated and catalytically inactive isoform of KDM5B histone demethylase accumulates in breast cancer cells and regulates H3K4 tri-methylation and gene expression

T. Bonaldi, R. Noberini, A. Paiardini, 2023, Cancer Gene Therapy.

Structural investigation of nucleophosmin interaction with the tumor suppressor Fbw7γ

L. Vitagliano, L. Federici, A. Paiardini, 2017, Oncogenesis.

Phosphorylation, Mg-ADP, and Inhibitors Differentially Shape the Conformational Dynamics of the A-Loop of Aurora-A

A. Paiardini, A. Grottesi, G. Guarguaglini, 2021, Biomolecules.

A novel germline mutation in CDK4 codon 24 associated to familial melanoma

C. Mecucci, I. Bottillo, A. Paiardini, 2018, Clinical genetics.

A conserved scaffold with heterogeneous metal ion binding site: the multifaceted example of HD-GYP proteins

A. Paiardini, F. Cutruzzolà, A. Paone, 2022, Coordination Chemistry Reviews.

Structure and Function of HD-GYP Phosphodiesterases

A. Paiardini, F. Cutruzzolà, A. Paone, 2020 .

SMaRT lncRNA controls translation of a G‐quadruplex‐containing mRNA antagonizing the DHX36 helicase

I. Bozzoni, Tiziana Santini, A. Paiardini, 2020, EMBO reports.

Insights into the interaction of sortilin with proneurotrophins: A computational approach

V. Caputo, A. Paiardini, 2008, Neuropeptides.

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors.

Shailesh N Mistry, S. McGowan, A. Paiardini, 2014, Journal of medicinal chemistry.

Molecular defects of the glycine 41 variants of alanine glyoxylate aminotransferase associated with primary hyperoxaluria type I

A. Paiardini, Elisa Oppici, R. Montioli, 2010, Proceedings of the National Academy of Sciences.

Molecular Insight into the Synergism between the Minor Allele of Human Liver Peroxisomal Alanine:Glyoxylate Aminotransferase and the F152I Mutation*

A. Paiardini, R. Montioli, Antonio Lorenzetto, 2009, Journal of Biological Chemistry.

Dimerization and folding processes of Treponema denticola cystalysin: the role of pyridoxal 5'-phosphate.

D. Laurents, A. Paiardini, M. Bertoldi, 2006, Biochemistry.

PyMod 2.0: improvements in protein sequence-structure analysis and homology modeling within PyMOL.

A. Paiardini, G. Janson, Chengxin Zhang, 2016, Bioinformatics.

Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis

A. Paiardini, R. Montanari, A. Laghezza, 2017, Scientific Reports.

The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule cyclic-di-GMP by interfering with intracellular nucleotide pool availability

A. Paiardini, F. Cutruzzolà, E. Rossi, 2013, Applied Microbiology and Biotechnology.

Insights into PPARγ phosphorylation and its inhibition mechanism.

A. Heck, A. Paiardini, A. Grottesi, 2020, Journal of medicinal chemistry.

A Short ERAP2 That Binds IRAP Is Expressed in Macrophages Independently of Gene Variation

A. Paiardini, S. Caristi, F. Paladini, 2022, International journal of molecular sciences.

A short ERAP2 that binds IRAP is expressed in macrophages independently from gene variation

A. Paiardini, S. Caristi, F. Paladini, 2022, bioRxiv.

PLP-Dependent Enzymes

A. Buckle, A. Paiardini, B. Cellini, 2014, BioMed research international.

Expression of Bv8 in Pichia pastoris to identify structural features for receptor binding.

A. Paiardini, D. Barra, M. C. Bonaccorsi di Patti, 2010, Protein expression and purification.

Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity

C. Limatola, A. Paiardini, F. Cutruzzolà, 2020, Cell Death & Disease.

Heterozygosis in aromatic amino acid decarboxylase deficiency: Evidence for a positive interallelic complementation between R347Q and R358H mutations

A. Paiardini, M. Bertoldi, G. Janson, 2018, IUBMB life.

Molecular insights into primary hyperoxaluria type 1 pathogenesis.

A. Paiardini, Elisa Oppici, R. Montioli, 2012, Frontiers in bioscience.

Molecular insights into primary hyperoxaluria type i pathogenesis

A. Paiardini, Elisa Oppici, R. Montioli, 2012 .

A novel compound heterozygous genotype associated with aromatic amino acid decarboxylase deficiency: Clinical aspects and biochemical studies.

R. Battini, A. Paiardini, M. Bertoldi, 2019, Molecular genetics and metabolism.

An engineered folded PLP‐bound monomer of Treponema denticola cystalysin reveals the effect of the dimeric structure on the catalytic properties of the enzyme

A. Paiardini, M. Bertoldi, R. Montioli, 2009, Proteins.

Reactions of human liver peroxisomal alanine:glyoxylate aminotransferase with beta-chloro-L-alanine and L-cysteine: spectroscopic and kinetic analysis.

A. Paiardini, M. Bertoldi, R. Montioli, 2008, Biochimica et biophysica acta.

Insight into the structure–function relationship of the nonheme iron halogenases involved in the biosynthesis of 4‐chlorothreonine – Thr3 from Streptomyces sp. OH‐5093 and SyrB2 from Pseudomonas syringae pv. syringae B301DR

S. Ōmura, S. Pascarella, A. Paiardini, 2012, The FEBS journal.

Identification by Virtual Screening and In Vitro Testing of Human DOPA Decarboxylase Inhibitors

Francesco Bossa, Antonio Macchiarulo, Alessandro Paiardini, 2012, PloS one.

Structural mimicry between SLA/LP and Rickettsia surface antigens as a driver of autoimmune hepatitis: insights from an in silico study

S. Pascarella, A. Paiardini, 2013, Theoretical Biology and Medical Modelling.

Structural stability of the cofactor binding site in Escherichia coli serine hydroxymethyltransferase – the role of evolutionarily conserved hydrophobic contacts

F. Bossa, R. Chiaraluce, V. Consalvi, 2009, The FEBS journal.

R180T variant of δ‐ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X‐ray and NMR studies provide insight into its catalytic features

Serena Zanzoni, A. Paiardini, F. Cutruzzolà, 2019, The FEBS journal.

Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis

A. Paiardini, F. Cutruzzolà, G. Giardina, 2017, Scientific Reports.

Familial hypomagnesaemia, Hypercalciuria and Nephrocalcinosis associated with a novel mutation of the highly conserved leucine residue 116 of Claudin 16 in a Chinese patient with a delayed diagnosis: a case report

I. Bottillo, A. Paiardini, Jingru Lu, 2018, BMC Nephrology.

THE RIBOREGULATION MECHANISM OF HUMAN SERINE HYDROXYMETHYLTRANSFERASE IS ROOTED IN AN ALLOSTERIC SWITCH

M. Bolognesi, Alok Bharadwaj, L. C. Montemiglio, 2023, bioRxiv.

First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8

D. Trisciuoglio, A. Mai, G. Sbardella, 2023, Journal of medicinal chemistry.

AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation

A. Paiardini, I. A. Asteriti, G. Guarguaglini, 2023, Life Science Alliance.

Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming.

A. Paiardini, B. Maras, F. Cutruzzolà, 2016, Biochimica et biophysica acta.

Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells

Martina Kunkl, Carola Amormino, L. Tuosto, 2023, Frontiers in Immunology.

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum Aminopeptidases, M1, M17 and M18

Shailesh N Mistry, S. McGowan, A. Paiardini, 2015, PloS one.

Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes.

J. Menéndez, A. Paiardini, F. Cutruzzolà, 2018, Archives of biochemistry and biophysics.

The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase

F. Bossa, R. Chiaraluce, V. Consalvi, 2009, The FEBS journal.

Evolutionarily conserved regions and hydrophobic contacts at the superfamily level: The case of the fold‐type I, pyridoxal‐5′‐phosphate‐dependent enzymes

Stefano Pascarella, Francesco Bossa, Alessandro Paiardini, 2004, Protein science : a publication of the Protein Society.

Prediction and Modeling of Protein–Protein Interactions Using “Spotted” Peptides with a Template-Based Approach

A. Paiardini, G. Janson, Dalila Boi, 2022, Biomolecules.

DockingPie: a consensus docking plugin for PyMOL

A. Paiardini, Serena Rosignoli, 2022, Bioinform..

Biochemical data from the characterization of a new pathogenic mutation of human pyridoxine-5'-phosphate oxidase (PNPO)

I. Nogués, R. Guerrini, A. Paiardini, 2017, Data in brief.

Fatty Acids Abolish Shigella Virulence by Inhibiting Its Master Regulator, VirF

A. Paiardini, B. Colonna, A. Tramonti, 2023, Microbiology spectrum.

The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule cyclic-di-GMP by interfering with intracellular nucleotide pool availability

A. Paiardini, F. Cutruzzolà, E. Rossi, 2013, Applied Microbiology and Biotechnology.

Synthesis of Triazole-Linked Analogues of c-di-GMP and Their Interactions with Diguanylate Cyclase.

A. Paiardini, F. Cutruzzolà, R. Petrelli, 2015, Journal of medicinal chemistry.

Prenatal whole exome sequencing detects a new homozygous fukutin (FKTN) mutation in a fetus with an ultrasound suspicion of familial Dandy–Walker malformation

T. Mazza, V. Caputo, A. Pizzuti, 2019, Molecular genetics & genomic medicine.

Revisiting degron motifs in human AURKA required for its targeting by APC/CFZR1

A. Hagting, A. Paiardini, I. A. Asteriti, 2022, Life Science Alliance.

Diffusible signal factors (DSFs) bind and repress VirF, the leading virulence activator of Shigella flexneri

A. Paiardini, B. Colonna, A. Tramonti, 2023, Scientific reports.

Structural analysis of toxic volkensin, a type 2 ribosome inactivating protein from Adenia volkensii Harm (kilyambiti plant): molecular modeling and surface analysis by computational methods and limited proteolysis.

A. Chambery, A. Parente, S. Pascarella, 2009, International journal of biological macromolecules.

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.

Shailesh N Mistry, S. McGowan, A. Paiardini, 2016, European journal of medicinal chemistry.

An engineered folded PLP‐bound monomer of Treponema denticola cystalysin reveals the effect of the dimeric structure on the catalytic properties of the enzyme

A. Paiardini, M. Bertoldi, R. Montioli, 2009, Proteins.

On the catalytic mechanism and stereospecificity of Escherichia coli l‐threonine aldolase

A. Paiardini, S. Remesh, M. Safo, 2014, The FEBS journal.

Meet Our Editorial Board Member

A. Paiardini, 2022, Current Bioinformatics.

S. Ōmura, S. Pascarella, A. Paiardini, 2012, The FEBS journal.

Discovering Selective Diguanylate Cyclase Inhibitors: From PleD to Discrimination of the Active Site of Cyclic-di-GMP Phosphodiesterases.

A. Paiardini, F. Cutruzzolà, A. Paone, 2017, Methods in molecular biology.

Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases

S. Gianni, A. Paiardini, F. Cutruzzolà, 2011, Proceedings of the National Academy of Sciences of the United States of America.

The novel R347g pathogenic mutation of aromatic amino acid decarboxylase provides additional molecular insights into enzyme catalysis and deficiency.

A. Paiardini, M. Bertoldi, S. Heales, 2016, Biochimica et biophysica acta.

How pyridoxal 5′‐phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state

A. Buckle, A. Paiardini, F. Cutruzzolà, 2015, The FEBS journal.

Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis

A. Paiardini, R. Montanari, D. Capelli, 2017, Scientific Reports.

The phytotoxin fusicoccin differently regulates 14‐3‐3 proteins association to mode III targets

S. Pascarella, A. Paiardini, F. Cutruzzolà, 2014, IUBMB life.

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors.

Shailesh N Mistry, S. McGowan, A. Paiardini, 2014, Journal of medicinal chemistry.

X‐ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti‐malarial drug targets PfA‐M1 and PfA‐M17

S. McGowan, A. Paiardini, R. Bamert, 2015, Proteins.

Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa.

A. Mai, A. Paiardini, F. Cutruzzolà, 2023, Microbiological research.

A novel germline mutation in CDK4 codon 24 associated to familial melanoma

I. Bottillo, A. Paiardini, S. Bargiacchi, 2018, Clinical genetics.

Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1.

Alok Bharadwaj, L. C. Montemiglio, A. Paiardini, 2024, Molecular cell.

PyMod 2.0: improvements in protein sequence-structure analysis and homology modeling within PyMOL

A. Paiardini, G. Janson, Chengxin Zhang, 2017, Bioinform..