L. Narhi

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Chemical Modifications in Therapeutic Protein Aggregates Generated under Different Stress Conditions

Linda O. Narhi, Randal R. Ketchem, Jette Wypych, 2011, The Journal of Biological Chemistry.

Characterization of the protein expressed in Escherichia coli by a recombinant plasmid containing the Bacillus megaterium cytochrome P-450BM-3 gene

L. Narhi, A. Fulco, L. Wen, 2004, Molecular and Cellular Biochemistry.

Effect of the intermolecular disulfide bond on the conformation and stability of glial cell line-derived neurotrophic factor.

T. Arakawa, J. Philo, L. Narhi, 2002, Protein engineering.

Chemical and Biophysical Characteristics of Monoclonal Antibody Solutions Containing Aggregates Formed during Metal Catalyzed Oxidation

K. Fujimori, W. Jiskoot, Q. Luo, 2017, Pharmaceutical Research.

Engineering an IgG Scaffold Lacking Effector Function with Optimized Developability*

Weiqi Wang, K. Gunasekaran, Kristi Daris, 2016, The Journal of Biological Chemistry.

The conformational stability of a non-covalent dimer of a platelet-derived growth factor-B mutant lacking the two cysteines involved in interchain disulfide bonds.

T. Arakawa, W. Kenney, L. Narhi, 2009, International journal of peptide and protein research.

Using Differential Scanning Calorimetry in Understanding the Correlation Between Thermal Stability and Protein Stability : A Case Study

Ke Gong, L. Narhi, J. Wen, 2007 .

The effect of carbohydrate on the structure and stability of erythropoietin.

T. Arakawa, T. Boone, L. Narhi, 1991, The Journal of biological chemistry.

Dimerization of the extracellular domain of the erythropoietin (EPO) receptor by EPO: one high-affinity and one low-affinity interaction.

T. Arakawa, J. Philo, K. Aoki, 1996, Biochemistry.

Physical and biophysical effects of polysorbate 20 and 80 on darbepoetin alfa.

L. Narhi, B. Kerwin, S. Deechongkit, 2009, Journal of pharmaceutical sciences.

Interfacial Stress in the Development of Biologics: Fundamental Understanding, Current Practice, and Future Perspective

M. Huang, M. Krause, L. Narhi, 2019, The AAPS Journal.

Mouse Models for Assessing Protein Immunogenicity: Lessons and Challenges.

W. Jiskoot, M. Joubert, L. Narhi, 2016, Journal of pharmaceutical sciences.

White Paper Interfacial Stress in the Development of Biologics : Fundamental Understanding , Current Practice , and Future Perspective

Min Huang, M. Krause, L. Narhi, 2019 .

Classification of protein aggregates.

Linda O Narhi, J. Schmit, L. Narhi, 2012, Journal of pharmaceutical sciences.

Characterization of Subvisible Particles in Biotherapeutic Pre-Filled Syringes: The Role of Polysorbate and Protein on the Formation of Silicone Oil and Protein Subvisible Particles After Drop Shock.

M. Joubert, L. Narhi, N. Joh, 2019, Journal of pharmaceutical sciences.

A multi-company assessment of submicron particle levels by NTA and RMM in a wide range of late-phase clinical and commercial biotechnology-derived protein products.

L. Narhi, T. Das, S. Cao, 2019, Journal of pharmaceutical sciences.

Physical characterization and in vitro biological impact of highly aggregated antibodies separated into size-enriched populations by fluorescence-activated cell sorting.

D. Volkin, C. R. Middaugh, M. Joubert, 2015, Journal of pharmaceutical sciences.

A critical review of analytical methods for subvisible and visible particles.

L. Narhi, S. Cao, Yijia Jiang, 2009, Current pharmaceutical biotechnology.

Enhanced stability of recombinant keratinocyte growth factor by mutagenesis.

T. Arakawa, W. Kenney, T. Osslund, 2006, Protein engineering, design & selection : PEDS.

Correlation between the 1.6 Å crystal structure and mutational analysis of keratinocyte growth factor

T. Arakawa, A. Chirino, T. Harvey, 1998, Protein science : a publication of the Protein Society.

Purification and characterization of pentobarbital-induced cytochrome P-450BM-1 from Bacillus megaterium ATCC 14581.

L. Narhi, A. Fulco, H. Schwalb, 1985, Biochimica et biophysica acta.

Formation of an active dimer during storage of interleukin-1 receptor antagonist in aqueous solution.

T. Arakawa, L. Narhi, B. Chang, 1996, Biophysical journal.

Fractionation of polyclonal antibodies to fragments of a neuroreceptor using three increasingly chaotropic solvents.

D. Wen, T. Arakawa, L. Narhi, 1999, Journal of chromatography. B, Biomedical sciences and applications.

α-Synuclein fibrillogenesis as target for drug development

M. Citron, L. Narhi, J. Wypych, 2001 .

Stress Factors in Protein Drug Product Manufacturing and Their Impact on Product Quality.

W. Jiskoot, L. Narhi, Danny K. Chou, 2021, Journal of pharmaceutical sciences.

Molecular Biophysics for the Life Sciences

N. Allewell, I. Rayment, L. Narhi, 2013, Biophysics for the Life Sciences.

Recombinant rat fibroblast growth factor-16: structure and biological activity.

T. Arakawa, J. Philo, F. Martin, 1999, Archives of biochemistry and biophysics.

Effects of peptide length and composition on binding to an empty class I MHC heterodimer.

P. Bjorkman, L. Narhi, J. Johnson, 1994, Biochemistry.

Use of In Vitro Assays to Assess Immunogenicity Risk of Antibody-Based Biotherapeutics

M. Joubert, L. Narhi, G. C. Flynn, 2016, PloS one.

Parkinson's disease-associated alpha-synuclein is more fibrillogenic than beta- and gamma-synuclein and cannot cross-seed its homologs.

M. Citron, D. Anafi, L. Narhi, 2000, The Journal of biological chemistry.

Formation of heterodimers from three neurotrophins, nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor.

J. Miller, T. Arakawa, J. Philo, 1994, The Journal of biological chemistry.

Phenobarbital induction of a soluble cytochrome P-450-dependent fatty acid monooxygenase in Bacillus megaterium.

L. Narhi, A. Fulco, 1982, The Journal of biological chemistry.

Putative folding pathway of insulin-like growth factor-I.

J. Miller, V. Katta, T. Arakawa, 1997, Archives of biochemistry and biophysics.

Yeast-derived recombinant human insulin-like growth factor I: Production, purification, and structural characterization

T. Arakawa, S. Elliott, L. Narhi, 1990, Journal of protein chemistry.

Studies on the Structure and Function of Glycosylated and Nonglycosylated neu Differentiation Factors

Y. Yarden, J. Philo, L. Narhi, 1995, The Journal of Biological Chemistry.

Identification of a Lipopolysaccharide Binding Domain in CD14 between Amino Acids 57 and 64 (*)

M. Kelley, L. Narhi, S. Wright, 1995, The Journal of Biological Chemistry.

Interactions between NFκB and Its Inhibitor iκB: Biophysical Characterization of a NFκB/iκB-α Complex

T. Arakawa, J. Philo, J. Inoue, 1998 .

Development of a human antibody tolerant mouse model to assess the immunogenicity risk due to aggregated biotherapeutics.

T. Arora, M. Joubert, L. Narhi, 2013, Journal of pharmaceutical sciences.

Cloning and characterization of a gene encoding extracellular metalloprotease from Streptomyces lividans.

L. Narhi, G. Smith, H. Lichenstein, 1992, Gene.

Conformation of glutathione adduct and oxidized forms of platelet-derived growth factor.

T. Arakawa, W. Kenney, L. Narhi, 2009, International journal of peptide and protein research.

Thermal stability comparison of purified empty and peptide-filled forms of a class I MHC molecule.

P. Bjorkman, L. Narhi, M. Fahnestock, 1992, Science.

Investigation of the effects of altered receptor binding activity on the clearance of erythropoiesis-stimulating proteins: Nonerythropoietin receptor-mediated pathways may play a major role.

K. Aoki, S. Elliott, L. Narhi, 2009, Journal of pharmaceutical sciences.

The limited proteolysis of tumor necrosis factor-α

T. Arakawa, L. Narhi, P. Hunt, 1989 .

Dissociation of recombinant tumor necrosis factor-α studied by gel permeation chromatography

T. Arakawa, L. Narhi, 1987 .

Approaches to Control Protein Aggregation during Bulk Production

R. Deshpande, Sohye Kang, L. Narhi, 2010 .

Solid state fluorescence of lyophilized proteins.

L. Narhi, Tamer Eris, Cynthia H Li, 2008, Analytical biochemistry.

Granulocyte‐colony stimulating factor maintains a thermally stable, compact, partially folded structure at pH 2

C. Kolvenbach, T. Arakawa, J. Philo, 2009 .

Acid-induced unfolding of brain-derived neurotrophic factor results in the formation of a monomeric "a state".

T. Arakawa, J. Philo, L. Narhi, 1993, Biochemistry.

Changes in Conformation and Stability upon Formation of Complexes of Erythropoietin (EPO) and Soluble EPO Receptor

T. Arakawa, J. Philo, K. Aoki, 1997, Journal of protein chemistry.

Refolding of brain-derived neurotrophic factor from guanidine hydrochloride: kinetic trapping in a collapsed form which is incompetent for dimerization.

T. Arakawa, J. Philo, L. Narhi, 1993, Biochemistry.

Conformational changes of recombinant human granulocyte-colony stimulating factor induced bypH and guanidine hydrochloride

T. Arakawa, W. Kenney, L. Narhi, 1991, Journal of protein chemistry.

Strategies to suppress aggregation of recombinant keratinocyte growth factor during liquid formulation development.

T. Arakawa, L. Narhi, B. L. Chen, 1994, Journal of pharmaceutical sciences.

Ion‐specific modulation of protein interactions: Anion‐induced, reversible oligomerization of a fusion protein

Yatin R. Gokarn, D. Brems, L. Narhi, 2008, Protein science : a publication of the Protein Society.

An industry perspective on the monitoring of subvisible particles as a quality attribute for protein therapeutics.

S. Singh, M. Cromwell, L. Narhi, 2010, Journal of pharmaceutical sciences.

Stability of fungal α-amylase in sodium dodecylsulfate

T. Arakawa, L. Narhi, L. Hung, 1992 .

Protein-ligand interaction as a method to study surface properties of proteins.

T. Arakawa, L. Narhi, Y. Kita, 1991, Methods of biochemical analysis.

Hydrophobic interaction chromatography in alkaline pH.

T. Arakawa, L. Narhi, Y. Kita, 1989, Analytical biochemistry.

Enhanced stability of subtilisin by three point mutations

M. Levitt, C. Kolvenbach, T. Arakawa, 1991, Biotechnology and applied biochemistry.

Comparative study on proteinase R, T, and K from Tritirachiam album limber.

C. Kolvenbach, L. Narhi, B. Samal, 2009, International journal of peptide and protein research.

Sodium dodecyl sulfate polyacrylamide gel electrophoresis as a method for studying the stability of subtilisin.

T. Arakawa, L. Narhi, 1989, Biochimica et biophysica acta.

Stability of aprA-subtilisin in sodium dodecyl sulfate.

T. Arakawa, L. Narhi, M. Zukowski, 1988, Archives of biochemistry and biophysics.

Production and characterization of an analog of acidic fibroblast growth factor with enhanced stability and biological activity.

D. Rees, T. Arakawa, T. Horan, 1993, Protein engineering.

Characterization of a catalytically self-sufficient 119,000-dalton cytochrome P-450 monooxygenase induced by barbiturates in Bacillus megaterium.

L. Narhi, A. Fulco, L O Narhi, 1986, The Journal of biological chemistry.

Induction of alpha-helix in the beta-sheet protein tumor necrosis factor-alpha: thermal- and trifluoroethanol-induced denaturation at neutral pH.

T. Arakawa, J. Philo, L. Narhi, 1996, Biochemistry.

Properties of variant forms of human stem cell factor recombinantly expressed in Escherichia coli.

L. Narhi, E. Mendiaz, J. Pope, 1994, Archives of biochemistry and biophysics.

Recombinant production of native proteins from Escherichia coli.

T. Arakawa, L. Narhi, Tiansheng Li, 2002, Pharmaceutical biotechnology.

Chemical modification and site-directed mutagenesis of methionine residues in recombinant human granulocyte colony-stimulating factor: effect on stability and biological activity.

G Shimamoto, T. Horan, L. Narhi, 1999, Archives of biochemistry and biophysics.

Asn to Lys mutations at three sites which are N-glycosylated in the mammalian protein decrease the aggregation of Escherichia coli-derived erythropoietin.

T. Arakawa, T. Boone, J. Cheetham, 2001, Protein engineering.

Stress Factors in Monoclonal Antibody Drug Substance Production Processes: Critical Assessment of Impact on Product Quality and Control Strategy.

Alavattam Sreedhara, Vasco Filipe, Tapan K Das, 2019, Journal of pharmaceutical sciences.

Effect of Ions on Agitation- and Temperature-Induced Aggregation Reactions of Antibodies

Linda O. Narhi, Yatin R. Gokarn, Eva Kras, 2009, Pharmaceutical Research.

Anion Binding Mediated Precipitation of a Peptibody

Linda O. Narhi, Yatin R. Gokarn, Eva Kras, 2008, Pharmaceutical Research.

Highly Aggregated Antibody Therapeutics Can Enhance the in Vitro Innate and Late-stage T-cell Immune Responses

M. Joubert, L. Narhi, B. Kerwin, 2012, The Journal of Biological Chemistry.

Tungsten-induced protein aggregation: solution behavior.

Joey Pollastrini, Yijia Jiang, Gianni Torraca, 2009, Journal of pharmaceutical sciences.

Comparison of solution properties of human and rat ciliary neurotrophic factor.

T. Arakawa, J. Philo, L. Narhi, 2009, The journal of peptide research : official journal of the American Peptide Society.

Immunogenicity of Therapeutic Protein Aggregates.

Marisa K Joubert, Jainik P Panchal, Elizabeth M Topp, 2016, Journal of pharmaceutical sciences.

High level expression of human leukemia inhibitory factor (LIF) from a synthetic gene in Escherichia coli and the physical and biological characterization of the protein.

T. Arakawa, T. Jones, T. Boone, 1995, Biochimica et biophysica acta.

Glycosylated and unglycosylated recombinant-derived human stem cell factors are dimeric and have extensive regular secondary structure.

T. Arakawa, L. Narhi, J. Wypych, 1991, The Journal of biological chemistry.

Refolding and Oxidation of Recombinant Human Stem Cell Factor Produced in Escherichia coli(*)

Michael D. Jones, L. Narhi, Wen-Chang Chang, 1996, The Journal of Biological Chemistry.

Dimerization of the extracellular domain of granuloycte-colony stimulating factor receptor by ligand binding: a monovalent ligand induces 2:2 complexes.

T. Arakawa, J. Philo, T. Horan, 1996, Biochemistry.

Multiple conformational states of a new hematopoietic cytokine (megakaryocyte growth and development factor): pH‐ and urea‐induced denaturation

D. Brems, L. Narhi, James B. Hamburger, 1998, Proteins.

Qualification of FTIR spectroscopic method for protein secondary structural analysis.

Yijia Jiang, Linda Narhi, John P. Gabrielson, 2011, Journal of pharmaceutical sciences.

High throughput thermostability screening of monoclonal antibody formulations.

Linda O Narhi, Feng He, Vladimir I Razinkov, 2010, Journal of pharmaceutical sciences.

Both Familial Parkinson’s Disease Mutations Accelerate α-Synuclein Aggregation*

M. Citron, K. Sitney, D. Anafi, 1999, The Journal of Biological Chemistry.

Role of native disulfide bonds in the structure and activity of insulin-like growth factor 1: genetic models of protein-folding intermediates.

J. Miller, T. Arakawa, L. Narhi, 1993, Biochemistry.

Oxidative refolding of insulin-like growth factor 1 yields two products of similar thermodynamic stability: a bifurcating protein-folding pathway.

J. Miller, T. Arakawa, L. Narhi, 1993, Biochemistry.

Recombinant human erythropoietin (rHuEPO): Cross‐linking with disuccinimidyl esters and identification of the interfacing domains in EPO

T. Arakawa, S. Elliott, L. Narhi, 1993, Protein science : a publication of the Protein Society.

Identification and characterization of two functional domains in cytochrome P-450BM-3, a catalytically self-sufficient monooxygenase induced by barbiturates in Bacillus megaterium.

L. Narhi, A. Fulco, Linda Owers NarhiS, 1987, The Journal of biological chemistry.

Root Cause Analysis of Tungsten-Induced Protein Aggregation in Pre-filled Syringes.

Yijia Jiang, Wei Liu, Gianni Torraca, 2010, PDA journal of pharmaceutical science and technology.

Classification and Characterization of Therapeutic Antibody Aggregates

Marisa K Joubert, Yasser Nashed-Samuel, Jette Wypych, 2011, The Journal of Biological Chemistry.

Optical Spectroscopic Methods for the Analysis of Biological Macromolecules

J. Švitel, L. Narhi, Cynthia H Li, 2013 .

The importance of Arg40 and 45 in the mitogenic activity and structural stability of basic fibroblast growth factor: Effects of acidic amino acid substitutions

D. Rees, T. Arakawa, J. Philo, 1995, Journal of protein chemistry.

In vitro methionine oxidation of escherichia coli‐derived human stem cell factor: Effects on the molecular structure, biological activity, and dimerization

L. Narhi, C. Spahr, L O Narhi, 1996, Protein science : a publication of the Protein Society.

Effect of three elution buffers on the recovery and structure of monoclonal antibodies.

T. Arakawa, T. Horan, D. Chang, 1997, Analytical biochemistry.

The Majority of Stem Cell Factor Exists as Monomer under Physiological Conditions

T. Boone, R. Syed, L. Narhi, 1997, The Journal of Biological Chemistry.

Folding and oxidation of recombinant human granulocyte colony stimulating factor produced in Escherichia coli. Characterization of the disulfide-reduced intermediates and cysteine----serine analogs.

L. Narhi, H. Lu, L O Narhi, 1992, The Journal of biological chemistry.

Applications of circular dichroism (CD) for structural analysis of proteins: qualification of near- and far-UV CD for protein higher order structural analysis.

Yijia Jiang, Letha Chemmalil, Linda Narhi, 2011, Journal of pharmaceutical sciences.

Interfacial Stress in the Development of Biologics: Fundamental Understanding, Current Practice, and Future Perspective

M. Krause, L. Narhi, R. Tu, 2019, The AAPS Journal.

Characterization of two fluorescent tryptophans in recombinant human granulocyte-colony stimulating factor: Comparison of native sequence protein and tryptophan-deficient mutants

C. Kolvenbach, T. Arakawa, L. Narhi, 1993, Journal of protein chemistry.

High-throughput dynamic light scattering method for measuring viscosity of concentrated protein solutions.

Jennifer R Litowski, Linda O Narhi, Feng He, 2010, Analytical biochemistry.

Native and non-native structure in a protein-folding intermediate: spectroscopic studies of partially reduced IGF-I and an engineered alanine model.

R Rosenfeld, J A Miller, J. Miller, 1996, Journal of molecular biology.

Detection of IgG aggregation by a high throughput method based on extrinsic fluorescence.

Robert Bailey, Linda O Narhi, Feng He, 2010, Journal of pharmaceutical sciences.

Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis.

Theodore W Randolph, Brent S Kendrick, Eva Y Chi, 2003, Biochemistry.

Silicone Oil Particles in Pre-Filled Syringes with Human Monoclonal Antibody Representative of Real-World Drug Products Did Not Increase Immunogenicity in In Vivo and In Vitro Model Systems.

M. Joubert, L. Narhi, N. Joh, 2019, Journal of pharmaceutical sciences.

Fractionation and characterization of polyclonal antibodies using three progressively more chaotropic solvents.

T. Arakawa, T. Horan, D. Chang, 1997, Analytical biochemistry.

Field-Flow Fractionation in Therapeutic Protein Development

L. Narhi, S. Cao, Yijia Jiang, 2012 .

Circular dichroism of reduced and oxidized recombinant human epidermal growth factor.

T. Arakawa, L. Narhi, M. Mcginley, 2009, International journal of peptide and protein research.

Parkinson's Disease-associated α-Synuclein Is More Fibrillogenic than β- and γ-Synuclein and Cannot Cross-seed Its Homologs*

M. Citron, D. Anafi, L. Narhi, 2000, The Journal of Biological Chemistry.

Dissociation of recombinant tumor necrosis factor-alpha studied by gel permeation chromatography.

T. Arakawa, L. Narhi, 1987, Biochemical and biophysical research communications.

High-throughput assessment of thermal and colloidal stability parameters for monoclonal antibody formulations.

Linda O Narhi, Feng He, Vladimir I Razinkov, 2011, Journal of pharmaceutical sciences.

Comparison of the biophysical characteristics of human brain-derived neurotrophic factor, neurotrophin-3, and nerve growth factor.

J. Miller, C. Kolvenbach, T. Arakawa, 1993, The Journal of biological chemistry.

Sites of iodination in recombinant human brain‐derived neurotrophic factor and its effect on neurotrophic activity

T. Arakawa, J. Philo, T. Boone, 1993, Protein science : a publication of the Protein Society.

CD14: Physical Properties and Identification of an Exposed Site That Is Protected by Lipopolysaccharide (*)

L. Narhi, S. Wright, M. Mcginley, 1995, The Journal of Biological Chemistry.

Sub-visible particle quantitation in protein therapeutics.

A. Mire-Sluis, L. Narhi, S. Cao, 2009, Pharmeuropa bio & scientific notes.

Analytical Methods to Measure Subvisible Particulates

Rahul S. Rajan, L. Narhi, S. Cao, 2012 .

Reversibility of Heat-Induced Denaturation of the Recombinant Human Megakaryocyte Growth and Development Factor

T. Arakawa, J. Philo, L. Narhi, 1999, Pharmaceutical Research.

Sodium Chloride Enhances the Storage and Conformational Stability of BDNF and PEG-BDNF

L. Narhi, M. Treuheit, A. Kosky, 2001, Pharmaceutical Research.

In Vitro Methionine Oxidation of Recombinant Human Leptin

Linda O. Narhi, V. Katta, L. Narhi, 1998, Pharmaceutical Research.

Isolation and Characterization of a Disulfide-linked Human Stem Cell Factor Dimer

L. Narhi, E. Mendiaz, Hsieng S. Lu, 1996, The Journal of Biological Chemistry.

Biochemical, biophysical, and pharmacological characterization of bacterially expressed human agouti-related protein.

V. Katta, J. Philo, J. Delaney, 1998, Biochemistry.

Interactions between NFkappaB and its inhibitor ikappaB: biophysical characterization of a NFkappaB/ikappaB-alpha complex.

T. Arakawa, J. Philo, J. Inoue, 1998, Journal of Protein Chemistry.

Screening of monoclonal antibody formulations based on high-throughput thermostability and viscosity measurements: design of experiment and statistical analysis.

Feng He, J. Litowski, L. Narhi, 2011, Journal of pharmaceutical sciences.

The effects of in vitro methionine oxidation on the bioactivity and structure of human keratinocyte growth factor

L. Narhi, C. Spahr, Hsieng S. Lu, 1997 .

Mutation of Arg55/56 to Leu55/Ala56 in insulin-like growth factor-I results in two forms different in disulfide structure and native conformation but similar under reverse-phase conditions

T. Arakawa, L. Narhi, M. Rohde, 1993, Journal of protein chemistry.

Immunogenicity of Therapeutic Protein Aggregates.

M. Joubert, L. Narhi, E. Topp, 2016, Journal of pharmaceutical sciences.

Screening of monoclonal antibody formulations based on high-throughput thermostability and viscosity measurements: design of experiment and statistical analysis.

J. Litowski, L. Narhi, B. Kerwin, 2011, Journal of pharmaceutical sciences.

Qualification of FTIR spectroscopic method for protein secondary structural analysis.

John P. Gabrielson, L. Narhi, S. Muzammil, 2011, Journal of pharmaceutical sciences.

Biological Characterization of a Stable Effector Functionless (SEFL) Monoclonal Antibody Scaffold in Vitro*

K. Gunasekaran, Riki Stevenson, L. Narhi, 2016, The Journal of Biological Chemistry.

Classification of protein aggregates.

J. Schmit, L. Narhi, D. Sharma, 2012, Journal of pharmaceutical sciences.

Cysteine 17 of recombinant human granulocyte-colony stimulating factor is partially solvent-exposed

T. Arakawa, T. Boone, W. Kenney, 1993, Journal of protein chemistry.

Solution structure and dynamics of epidermal growth factor and transforming growth factor alpha.

T. Arakawa, L. Narhi, S. Prestrelski, 1992, The Journal of biological chemistry.

Chemical Modifications in Therapeutic Protein Aggregates Generated under Different Stress Conditions

Randal R Ketchem, Q. Luo, M. Joubert, 2011, The Journal of Biological Chemistry.