S. Salvadori

发表

Effect of the three-dimensional structure on the deamidation reaction of ribonuclease A.

S. Capasso, S. Salvadori, 1999, The journal of peptide research : official journal of the American Peptide Society.

Effect of δ-Opioid Receptor Activation on BDNF-TrkB vs. TNF-α in the Mouse Cortex Exposed to Prolonged Hypoxia

S. Salvadori, Xuesong Tian, F. Hua, 2013, International journal of molecular sciences.

Emerging evidence for neurotensin receptor 1 antagonists as novel pharmaceutics in neurodegenerative disorders.

K. Fuxe, L. Ferraro, S. Tanganelli, 2009, Mini reviews in medicinal chemistry.

Structure–activity relationship study on Tyr9 of urotensin-II(4–11): Identification of a partial agonist of the UT receptor

S. Salvadori, D. Lambert, G. Calo’, 2009, Peptides.

Structure–activity relationship study of position 4 in the urotensin-II receptor ligand U-II(4-11)

S. Salvadori, D. Lambert, G. Calo’, 2008, Peptides.

Structure–activity relationship study on human urotensin II

S. Salvadori, G. Calo’, R. Guerrini, 2005, Journal of peptide science : an official publication of the European Peptide Society.

Urantide mimics urotensin-II induced calcium release in cells expressing recombinant UT receptors.

D. Behm, S. Douglas, S. Salvadori, 2004, European journal of pharmacology.

A new ligand for the urotensin II receptor

E. Kostenis, S. Salvadori, G. Calo’, 2002, British journal of pharmacology.

Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Cα,α-dialkylated amino acids

S. Salvadori, D. Lambert, G. Calo’, 2007 .

Nociceptin/orphanin FQ receptor ligands

S. Salvadori, G. Calo’, R. Guerrini, 2000, Peptides.

In vitro and in vivo characterization of the bifunctional μ and δ opioid receptor ligand UFP‐505

S. Salvadori, C. Ghelardini, D. Lambert, 2018, British journal of pharmacology.

Proteinase‐activated receptor‐1 (PAR‐1) activation contracts the isolated human renal artery in vitro

M. D'Andrea, S. Salvadori, R. Guerrini, 2003, British journal of pharmacology.

Preparation of mono-radioiodinated tracers for study of the in vivo metabolism of atrial natriuretic peptide in humans

S. Salvadori, M. Andreassi, D. Giannessi, 1995, European Journal of Nuclear Medicine.

Chemotactic response of human monocytes to pentapeptide analog derived from immunodeficiency virus protein gp 120

S. Salvadori, G. Balboni, R. Gavioli, 1990, Inflammation.

Urotensin II stimulates plasma extravasation in mice via UT receptor activation

S. Salvadori, G. Calo’, R. Guerrini, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

The SH3 domain of nebulin binds selectively to type II peptides: theoretical prediction and experimental validation.

M. Helmer-Citterich, B. Brannetti, A. Pastore, 2002, Journal of molecular biology.

Opioid receptor selectivity alteration by single residue replacement: synthesis and activity profile of [Dmt1]deltorphin B.

S. Salvadori, A. Capasso, L. Sorrentino, 1996, European journal of pharmacology.

Perspectives of protein kinase C (PKC) inhibitors as anti-cancer agents.

A. Gonelli, G. Zauli, S. Salvadori, 2009, Mini reviews in medicinal chemistry.

Kinetics and mechanism of succinimide ring formation in the deamidation process of asparagine residues

L. Mazzarella, A. Zagari, S. Capasso, 1993 .

Interaction of calmodulin with the phosphofructokinase target sequence

P. Bayley, J. Feeney, S. Salvadori, 2004, FEBS letters.

PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice.

S. Salvadori, G. Balboni, S. Maione, 2015, Pharmacological research.

Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24.

S. Salvadori, D. Lambert, G. Calo’, 2009, European journal of pharmacology.

New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.

S. Salvadori, G. Balboni, J. Neumeyer, 2006, Journal of medicinal chemistry.

Dmt and opioid peptides: A potent alliance

S. Salvadori, Y. Okada, S. Bryant, 2003, Biopolymers.

Molecular dynamics conformations of deltorphin analogues advocate delta opioid binding site models.

S. Salvadori, R. Guerrini, S. Bryant, 1994, Peptide research.

Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold.

D. Rognan, S. Salvadori, G. Balboni, 2009, Bioorganic & medicinal chemistry letters.

Kinetics and mechanism of the reversible isomerization of aspartic acid residues in tetrapeptides

A. Zagari, S. Capasso, F. Sica, 1995 .

Synthesis, pharmacological evaluation and conformational investigation of endomorphin-2 hybrid analogues

S. Salvadori, G. Balboni, A. Sacchetti, 2012, Molecular Diversity.

Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.

S. Salvadori, G. Balboni, A. Abell, 2010, Bioorganic & medicinal chemistry letters.

Further Studies on the Dmt-Tic Pharmacophore: Hydrophobic Substituents at the C-Terminus Endow δ Antagonists To Manifest μ Agonism or μ Antagonism

S. Salvadori, G. Balboni, R. Guerrini, 1999 .

Rational design of dynorphin A analogues with δ-receptor selectivity and antagonism for δ- and κ-receptors

S. Salvadori, P. Temussi, A. Capasso, 1998 .

New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands.

S. Salvadori, G. Balboni, D. Tourwé, 2006, Journal of medicinal chemistry.

Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism.

S. Salvadori, G. Balboni, R. Guerrini, 2004, Journal of medicinal chemistry.

Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.

S. Salvadori, G. Balboni, R. Guerrini, 1997, Journal of medicinal chemistry.

Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia.

S. Salvadori, Y. Fujita, Y. Tsuda, 2003, Journal of medicinal chemistry.

Blockade of nociceptin/orphanin FQ–NOP receptor signalling produces antidepressant‐like effects: pharmacological and genetic evidences from the mouse forced swimming test

R. Bertorelli, S. Salvadori, G. Calo’, 2003, The European journal of neuroscience.

Endogenous nociceptin signaling and stress-induced analgesia

S. Salvadori, J. Mogil, G. Calo’, 2001, Neuroreport.

Structural and biological exploration of phe(3)-phe(4)-modified endomorphin-2 peptidomimetics.

S. Salvadori, G. Balboni, T. F. Murray, 2013, ACS medicinal chemistry letters.

Stereospecificity of amino acid side chains in deltorphin defines binding to opioid receptors.

W. E. Wilson, S. Salvadori, G. Balboni, 1992, Journal of medicinal chemistry.

Developmental Potential for Endomorphin Opioidmimetic Drugs

S. Salvadori, Y. Tsuda, Y. Okada, 2012, International journal of medicinal chemistry.

New δ-opioid antagonists as pharmacological probes

S. Salvadori, S. Bryant, L. Lazarus, 1998 .

Design of δ-opioid peptide antagonists for emerging drug applications

S. Salvadori, G. Balboni, R. Guerrini, 1998 .

Frog skin opioid peptides: a case for environmental mimicry.

S. Salvadori, S. Bryant, L. Lazarus, 1994, Environmental health perspectives.

Aminoxy analogs of leu-enkephalin.

S. Salvadori, E. Menegatti, R. Tomatis, 2009, International journal of peptide and protein research.

Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands.

V. Hruby, S. Salvadori, D. Lambert, 2015, British journal of anaesthesia.

Inhibition of human multidrug resistance P-glycoprotein 1 by analogues of a potent δ-opioid antagonist

S. Salvadori, G. Balboni, R. Guerrini, 2001, Brain Research.

In vitro and in vivo pharmacological characterization of the novel UT receptor ligand [Pen5,DTrp7,Dab8]urotensin II(4–11) (UFP‐803)

S. Douglas, S. Salvadori, D. Lambert, 2006, British journal of pharmacology.

Dermorphin decreases plasma LH levels in human: Evidence for a modulatory role of gonadal steroids

F. Petraglia, S. Salvadori, A. Genazzani, 1985, Peptides.

Synthesis and opioid activity of [Sar4]dermorphin-tetrapeptide analogues.

S. Salvadori, G. Balboni, M. Marastoni, 1984, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

Presence and bronchomotor activity of protease-activated receptor-2 in guinea pig airways.

L. Fabbri, C. Bertrand, S. Salvadori, 2000, American journal of respiratory and critical care medicine.

Succinimide‐mediated pathway for peptide bond cleavage: Kinetic study on an Asn‐Sar containing peptide

L. Mazzarella, S. Capasso, S. Salvadori, 1996 .

Nociceptin receptor activation inhibits tachykinergic non adrenergic non cholinergic contraction of guinea pig isolated bronchus.

L. Fabbri, S. Salvadori, G. Calo’, 1999, Life sciences.

Pharmacological Profile Of Nociceptin/Orphanin Fq Receptors

S. Salvadori, G. Calo’, R. Guerrini, 2002, Clinical and experimental pharmacology & physiology.

In vitro and in vivo pharmacological characterization of nociceptin/orphanin FQ tetrabranched derivatives

S. Salvadori, D. Lambert, C. Ruzza, 2014, British journal of pharmacology.

Neurobiology, pharmacology, and medicinal chemistry of neuropeptide S and its receptor

S. Salvadori, G. Calo’, R. Guerrini, 2010, Medicinal research reviews.

Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues

S. Salvadori, D. Lambert, G. Calo’, 2002, Naunyn-Schmiedeberg's Archives of Pharmacology.

Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin-(1-13)-peptide amide.

S. Salvadori, P. Temussi, G. Calo’, 1997, Journal of medicinal chemistry.

Synthesis and antimicrobial activity of dermaseptin S1 analogues.

S. Salvadori, R. Guerrini, D. Savoia, 2008, Bioorganic & medicinal chemistry.

Interaction of deltorphin with opioid receptors: Molecular determinants for affinity and selectivity

W. E. Wilson, P. Grieco, S. Salvadori, 1993, Peptides.

Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic.

S. Salvadori, G. Balboni, J. Neumeyer, 2011, European journal of medicinal chemistry.

Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds.

S. Salvadori, G. Balboni, Y. Sasaki, 2010, Bioorganic & medicinal chemistry.

Evolution of the Bifunctional Lead μ Agonist/δ Antagonist Containing the 2′,6′-Dimethyl-l-tyrosine−1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Dmt−Tic) Opioid Pharmacophore

S. Salvadori, G. Balboni, J. Neumeyer, 2010 .

Structure-activity studies on the nociceptin/orphanin FQ receptor antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl} pyrrolidine-2-carboxamide.

S. Salvadori, D. Lambert, G. Calo’, 2009, Bioorganic & medicinal chemistry.

Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile.

S. Salvadori, D. Lambert, G. Calo’, 2009, British journal of anaesthesia.

Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging.

Xiaoyuan Chen, S. Salvadori, G. Balboni, 2008, Journal of medicinal chemistry.

Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502).

S. Salvadori, G. Balboni, F. Porreca, 2008, Bioorganic & medicinal chemistry.

In vitro and in vivo pharmacological profile of UFP‐512, a novel selective δ‐opioid receptor agonist; correlations between desensitization and tolerance

S. Salvadori, G. Balboni, M. Boulouard, 2007 .

A new opioid designed multiple ligand derived from the μ opioid agonist endomorphin-2 and the δ opioid antagonist pharmacophore Dmt-Tic

S. Salvadori, G. Balboni, S. Bryant, 2007 .

Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.

S. Salvadori, G. Balboni, M. Zotti, 2006, Journal of medicinal chemistry.

Prerequisite for His4 in deltorphin A for highδ opioid receptor selectivity

S. Salvadori, R. Guerrini, S. Bryant, 1994, Amino Acids.

Synthesis and opioid activity of N,N-dimethyl-Dmt-Tic-NH-CH(R)-R' analogues: acquisition of potent delta antagonism.

S. Salvadori, G. Balboni, R. Guerrini, 2003, Bioorganic & medicinal chemistry.

Pharmacology of [Tyr1]nociceptin analogs: receptor binding and bioassay studies

S. Salvadori, K. Varani, G. Calo’, 1999, Naunyn-Schmiedeberg's Archives of Pharmacology.

Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships

S. Salvadori, K. Varani, G. Calo’, 1998, British journal of pharmacology.

Opioid Diketopiperazines: Synthesis and Activity of a Prototypic Class of Opioid Antagonists

S. Salvadori, G. Balboni, R. Guerrini, 1997, Biological chemistry.

Single diastereomeric desaminotyrosylalanyl tetra- and heptapeptides with opioid antagonistic activity.

S. Salvadori, G. Balboni, S. Bryant, 2009, International journal of peptide and protein research.

δ Opioidmimetic Antagonists: Prototypes for Designing a New Generation of Ultraselective Opioid Peptides

S. Salvadori, P. Temussi, D. Picone, 1995, Molecular medicine.

Synthesis and receptor binding analysis of dermorphin hepta-, hexa- and pentapeptide analogues. Evidence for one- and two-side binding models for the mu-opioid receptor.

S. Salvadori, G. Balboni, S. Bryant, 2009, International journal of peptide and protein research.

[Dmt1]N/OFQ(1–13)‐NH2: a potent nociceptin/orphanin FQ and opioid receptor universal agonist

S. Salvadori, D. Lambert, P. Molinari, 2012, British journal of pharmacology.

Studies on trypsin inhibitors. Part I. Synthesis of protected peptides related to sequence 1-10 of porcine pancreatic secretory trypsin inhibitor II (Kazal).

S. Salvadori, R. Tomatis, R. Rocchi, 2009, International journal of peptide and protein research.

Solution and solid-state structure of the diketopiperazine of tyrosyl-tetrahydroisoquinoline-3-carboxylic acid.

S. Salvadori, G. Balboni, D. Picone, 2009, International journal of peptide and protein research.

Effect of somatostatin on growth hormone and prolactin response to dermorphin in man.

S. Salvadori, E. D. Degli Uberti, G. Trasforini, 1985, Acta endocrinologica.

Pharmacological characterization of nociceptin receptor: an in vitro study.

S. Salvadori, G. Calo’, R. Guerrini, 1997, Canadian journal of physiology and pharmacology.

Synthesis and pharmacological activity of the N-terminal dermorphin tetrapeptide analogs with CH2-NH peptide bond isosteres.

S. Salvadori, R. Guerrini, R. Tomatis, 2009, International journal of peptide and protein research.

DOES hemopressin bind metal ions in vivo?

S. Salvadori, H. Kozłowski, R. Guerrini, 2016, Dalton transactions.

A novel and facile synthesis of tetra branched derivatives of nociceptin/orphanin FQ.

S. Salvadori, G. Calo’, R. Guerrini, 2014, Bioorganic & medicinal chemistry.

Further studies on nociceptin-related peptides: discovery of a new chemical template with antagonist activity on the nociceptin receptor.

S. Salvadori, K. Varani, D. Lambert, 2000, Journal of medicinal chemistry.

Opioid infidelity: novel opioid peptides with dual high affinity for δ- and μ-receptors

S. Salvadori, S. Bryant, L. Lazarus, 1996, Trends in Neurosciences.

Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Calpha,alpha-dialkylated amino acids.

S. Salvadori, D. Lambert, G. Calo’, 2007, Bioorganic & medicinal chemistry.

Characterization of [Nphe1]nociceptin(1‐13)NH2, a new selective nociceptin receptor antagonist

S. Salvadori, D. Lambert, G. Calo’, 2000, British journal of pharmacology.

Differential knockdown of delta-opioid receptor subtypes in the rat brain by antisense oligodeoxynucleotides targeting mRNA.

S. Salvadori, A. Borsodi, G. Tóth, 1999, Antisense & nucleic acid drug development.

Neuropeptide S receptor ligands: a patent review (2005-2016)

S. Salvadori, S. Di Maro, C. Ruzza, 2017, Expert opinion on therapeutic patents.

Modeling of overloaded gradient elution of nociceptin/orphanin FQ in reversed-phase liquid chromatography.

S. Salvadori, A. Cavazzini, F. Dondi, 2005, Journal of chromatography. A.

In vivo measurement of ANP overall turnover and identification of its main metabolic pathways under steady state conditions in humans

S. Salvadori, S. Berti, G. Iervasi, 1995, Journal of endocrinological investigation.

Blockade of Nociceptin/orphanin Fq Receptor Signaling in Rat Substantia Nigra Pars Reticulata Stimulates Nigrostriatal Dopaminergic Transmission and Motor Behavior ,lys 15 ]n/ofq(1–13)-nh 2 ) (a Selective Nop Receptor Peptide Antagonist) Stimulated It. N/ofq Microinjected in the Sub- Stantia Nigra P

N. Mercuri, G. Franchi, S. Salvadori, 2022 .

Characterization of the locomotor activity-inhibiting effect of nociceptin/orphanin FQ in mice

S. Salvadori, G. Calo’, R. Guerrini, 2001, Naunyn-Schmiedeberg's Archives of Pharmacology.

Synthesis and biological activity of carboxyl terminally extended dermorphins.

S. Salvadori, G. Balboni, E. D. Degli Uberti, 2009, International journal of peptide and protein research.

Activation of DOR attenuates anoxic K+ derangement via inhibition of Na+ entry in mouse cortex.

S. Salvadori, D. Chao, G. Balboni, 2008, Cerebral cortex.

Effect of deltorphin on pituitary-adrenal response to insulin-induced hypoglycemia and ovine corticotropin-releasing hormone in healthy man.

S. Salvadori, F. Portaluppi, M. Ambrosio, 1992, The Journal of clinical endocrinology and metabolism.

Structure-Activity Studies on Neuropeptide S

S. Salvadori, C. Corti, G. Calo’, 2006, Journal of Biological Chemistry.

Prototypic Opioid Peptidomimetics Based on the Dmt-Aba-Gly Scaffold

S. Salvadori, G. Balboni, D. Tourwé, 2010 .

Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic.

S. Salvadori, G. Balboni, C. Trapella, 2008, Journal of medicinal chemistry.

In vitro activity of dermaseptin S1 derivatives against genital pathogens

S. Salvadori, A. Civra, M. Donalisio, 2010, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Intracardiac Neurons GVIA-Sensitive Calcium Channel Currents in Rat -Conotoxin ω Opioid Receptor-Mediated Inhibition of

S. Salvadori, D. Chao, G. Balboni, 2015 .

Dehydro-dermorphins. I. Influence of the stereo-orientation of aromatic groups in dermorphin-(1-5)-peptides to opioid activity.

S. Salvadori, G. Balboni, M. Marastoni, 2009, International journal of peptide and protein research.

Dehydro-dermorphins. II. Synthesis and biological activity of unsaturated dermorphin hexa and heptapeptides.

S. Salvadori, G. Balboni, M. Marastoni, 2009, International journal of peptide and protein research.

Dermorphin inhibits spinal nociceptive flexion reflex in humans

S. Salvadori, G. Nappi, G. Trasforini, 1986, Brain Research.

Reversed-phase HPLC study on the in vitro enzymic degradation of dermorphin

S. Salvadori, S. Scalia, M. Marastoni, 1986, Peptides.

Synthesis and opioid activity of partial retro-inverso analogs of dermorphin.

S. Salvadori, G. Balboni, M. Marastoni, 2009, International journal of peptide and protein research.

Synthetic tetrapeptides related to dermorphin: Potent long lasting analgesic action following subcutaneous administration

S. Salvadori, G. Balboni, M. Marastoni, 1985, Peptides.

Prolactin and growth hormone responses to dermorphin in patients with prolactin-secreting pituitary adenoma.

S. Salvadori, E. D. Degli Uberti, G. Trasforini, 1985, Metabolism: clinical and experimental.

Prolactin releasing and luteinizing hormone inhibiting activity of dermorphin shorter homologues in the rat.

D. Cocchi, S. Salvadori, E. D. Degli Uberti, 1985, Life sciences.

Dermorphin, a new opioid peptide, stimulates thyrotropin secretion in normal subjects

S. Salvadori, L. Braverman, E. Roti, 1984, Journal of endocrinological investigation.

Responses of plasma renin activity, aldosterone, adrenocorticotropin, and cortisol to dermorphin, a new synthetic potent opiate-like peptide, in man.

S. Salvadori, E. D. Degli Uberti, G. Trasforini, 1983, The Journal of clinical endocrinology and metabolism.

Prolactin-releasing activity of dermorphin, a new synthetic potent opiate-like peptide, in normal human subjects.

S. Salvadori, E. D. Degli Uberti, G. Trasforini, 1983, The Journal of clinical endocrinology and metabolism.

Synthesis and pharmacological activity of dermorphin and its N-terminal sequences.

S. Salvadori, R. Tomatis, G. Sarto, 2009, International journal of peptide and protein research.

The mouse vas deferens: a pharmacological preparation sensitive to nociceptin.

V. Neugebauer, S. Salvadori, G. Calo’, 1996, European journal of pharmacology.

Dermorphin tetra- and heptapeptide analogues containing a [3,4] amide bond replacement by a carbon-carbon double and single bond.

S. Salvadori, D. Tourwé, H. Pepermans, 2009, International journal of peptide & protein research.

Potent δ-Opioid Receptor Agonists Containing the Dmt−Tic Pharmacophore

S. Salvadori, G. Balboni, R. Guerrini, 2002 .

Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.

S. Salvadori, G. Balboni, R. Guerrini, 2002, Journal of Medicinal Chemistry.

UFP‐112 a Potent and Long‐Lasting Agonist Selective for the Nociceptin/Orphanin FQ Receptor

Maurizio Massi, Remo Guerrini, Girolamo Calo', 2011, CNS neuroscience & therapeutics.

In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor

S. Salvadori, G. Calo’, R. Guerrini, 2007, Peptides.

Pharmacological characterization of the nociceptin receptor mediating hyperalgesia in the mouse tail withdrawal assay

S. Salvadori, G. Calo’, L. Beani, 1998, British journal of pharmacology.

What peptides these deltorphins be 1 Paraphrased from Lucius Annaeus Seneca, “What fools these mortals be,” ca 4BCE–65ACE; Epistles 1, 3. 1

S. Salvadori, S. Bryant, L. Lazarus, 1999, Progress in Neurobiology.

Antagonism in opioid peptides: the role of conformation.

S. Salvadori, P. Temussi, 2004, Current topics in medicinal chemistry.

Blockade of Nociceptin/Orphanin FQ Transmission Attenuates Symptoms and Neurodegeneration Associated with Parkinson's Disease

S. Salvadori, M. Morari, R. Reinscheid, 2005, The Journal of Neuroscience.

Pharmacology of nociceptin and its receptor: a novel therapeutic target

S. Salvadori, G. Calo’, R. Guerrini, 2000, British journal of pharmacology.

[Nphe(1)]nociceptin-(1-13)-NH(2) antagonizes nociceptin effects in the mouse colon.

S. Salvadori, G. Calo’, R. Guerrini, 1999, European journal of pharmacology.

Solution conformation of nociceptin.

S. Salvadori, D. Picone, R. Spadaccini, 1997, Biochemical and biophysical research communications.

Nmr studies of a series of dehydrodermorphins

S. Salvadori, G. Balboni, P. Temussi, 1989, Biopolymers.

Dehydro-dermorphins. III. Circular dichroism investigation of conformation in solution.

S. Salvadori, G. Balboni, R. Tomatis, 2009, International journal of peptide and protein research.

Synthesis of 2′,6′‐dimethyltyrosine containing tritiated delta opioid‐receptor selective antagonist dipeptide ligands with extraordinary affinity

S. Salvadori, G. Balboni, I. Kertész, 1998 .

Alpha-beta-dehydro-amino acid residues in the design of peptide structures. Molecular and crystal structures of two folded dehydro peptides.

C. Toniolo, M. Crisma, S. Salvadori, 1992, International journal of biological macromolecules.

[d-Pen(p-tBuBzl)5]NPS, a novel ligand for the neuropeptide S receptor: structure activity and pharmacological studies

P. Grieco, S. Salvadori, C. Ruzza, 2014, Medicinal Chemistry Research.

Anxiolytic- and antidepressant-like activities of H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), a novel selective delta opioid receptor agonist

S. Salvadori, G. Balboni, D. Lambert, 2008, Peptides.

A new convenient synthetic method and preliminary pharmacological characterization of triazinediones as prokineticin receptor antagonists.

S. Salvadori, G. Balboni, A. Deplano, 2014, European journal of medicinal chemistry.

Studies on trypsin inhibitors. Part VIII. Synthesis of the protected octatriacontapeptide corresponding to the sequence 15-52 of porcine pancreatic secretory trypsin inhibitor II (Kazal).

S. Salvadori, R. Tomatis, R. Rocchi, 2009, International journal of peptide and protein research.

Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68).

S. Salvadori, R. Reinscheid, C. Ruzza, 2011, Journal of medicinal chemistry.

Solution structure of amyloid beta-peptide (25-35) in different media.

Giuseppe Sorrentino, Remo Guerrini, Severo Salvadori, 2004, Journal of medicinal chemistry.

Effect of deltorphin on behavior and hippocampal electrical activity in rabbits

A. Aloisi, S. Salvadori, F. Portaluppi, 1993, Physiology & Behavior.

Structure-activity relationship of [Nphe1]-NC-(1-13)-NH2, a pure and selective nociceptin/orphanin FQ receptor antagonist.

S. Salvadori, G. Calo’, R. Guerrini, 2001, The journal of peptide research : official journal of the American Peptide Society.

Characterization of nociceptin receptors in the periphery: in vitro and in vivo studies

C. Maggi, S. Salvadori, G. Calo’, 1999, Naunyn-Schmiedeberg's Archives of Pharmacology.

A new selective antagonist of the nociceptin receptor

S. Salvadori, G. Calo’, R. Guerrini, 1998, British journal of pharmacology.

Pharmacological characterization of the nociceptin receptor which mediates reduction of alcohol drinking in rats

S. Salvadori, C. Polidori, R. Ciccocioppo, 2002, Peptides.

Nociceptin binding sites in frog (Rana esculenta) brain membranes.

S. Salvadori, R. Guerrini, A. Borsodi, 1999, Biochemical and biophysical research communications.

Solution structure of nocistatin, a new peptide analgesic.

S. Salvadori, D. Picone, R. Guerrini, 2000, Biopolymers.

Studies on the antinociceptive effect of [Nphe1]nociceptin(1–13)NH2 in mice

R. Bertorelli, S. Salvadori, G. Calo’, 2001, Neuroscience Letters.

The nociceptin/orphanin FQ receptor antagonist, [Nphe1]NC(1‐13)NH2, potentiates morphine analgesia

S. Salvadori, G. Calo’, R. Guerrini, 2000, Neuroreport.

Inhibition of the development of morphine tolerance by a potent dual μ-/δ-opioid antagonist, H-Dmt-Tic-Lys-NH-CH2-Ph

S. Salvadori, G. Balboni, L. Lazarus, 2008, Pharmacology Biochemistry and Behavior.

Structure-activity relationships of cyclic and linear peptide T analogues.

S. Salvadori, G. Balboni, M. Marastoni, 2009, International journal of peptide and protein research.

Interaction of sweet proteins with their receptor. A conformational study of peptides corresponding to loops of brazzein, monellin and thaumatin.

A. Pastore, S. Salvadori, P. Temussi, 2004, European journal of biochemistry.

Daily intravesical instillation of 1 mg nociceptin/orphanin FQ for the control of neurogenic detrusor overactivity: a multicenter, placebo controlled, randomized exploratory study.

M. Spinelli, S. Salvadori, G. Calo’, 2006, The Journal of urology.

Assessment of substitution in the second pharmacophore of Dmt-Tic analogues.

G. Caliendo, V. Santagada, S. Salvadori, 2000, Bioorganic & medicinal chemistry letters.

Synthetic approach to non-isosteric peptidomimetics related to human endothelin.

S. Salvadori, G. Balboni, R. Rondanin, 1996, Advances in experimental medicine and biology.

δ-Opioid Receptor Activation Modified MicroRNA Expression in the Rat Kidney under Prolonged Hypoxia

S. Salvadori, D. Chao, G. Balboni, 2013, PloS one.

6- N,N -Dimethylamino-2,3-Naphthalimide a New Environment-Sensitive Fluorescent Probe in δ -Selective and μ -Selective Opioid Peptides

S. Salvadori, G. Balboni, M. Vázquez, 2007 .

Bivalent opioid peptides synthesized from μ selective monomers display preferential selectivity for δ receptors

S. Salvadori, L. Pasquinucci, S. Spampinato, 1990 .

Structure-activity relationships of nociceptin and related peptides: comparison with dynorphin A

S. Salvadori, G. Calo’, R. Guerrini, 2000, Peptides.

Opioid agonists and antagonists. Peptides containing N-terminal allyl groups and/or a thiomethylene linkage in place of a peptide bond

S. Salvadori, G. Balboni, M. Marastoni, 1988 .

Synthesis and activity profiles of new dermorphin-(1-4) peptide analogues.

S. Salvadori, G. Balboni, M. Marastoni, 1987, Journal of medicinal chemistry.

Synthesis and opioid activity of dermorphin tetrapeptides bearing D-methionine S-oxide at position 2.

S. Salvadori, G. Balboni, M. Marastoni, 1986, Journal of medicinal chemistry.

Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic.

S. Salvadori, G. Balboni, R. Argazzi, 2004, Journal of medicinal chemistry.

Function of negative charge in the "address domain" of deltorphins.

W. E. Wilson, V. Santagada, S. Salvadori, 1991, Journal of medicinal chemistry.

Opioid peptides. Synthesis and biological properties of dermorphin related hexapeptides

S. Salvadori, G. Balboni, M. Marastoni, 1990 .

Structure-activity studies on nociceptin/orphanin FQ: from full agonist, to partial agonist, to pure antagonist.

S. Salvadori, G. Calo’, R. Guerrini, 1999, Farmaco.

Studies on trypsin inhibitors. Part IX. Synthesis and trypsin inhibitory activity of the duopentacontapeptide corresponding to the amino acid sequence of porcine pancreatic secretory trypsin inhibitor II (Kazal).

S. Salvadori, R. Tomatis, R. Rocchi, 2009, International journal of peptide and protein research.

Studies on trypsin inhibitors. Part VII. Synthesis of protected peptides related to sequences 1 - 14 and 36 - 52 of porcine pancreatic secretory trypsin inhibitor II (Kazal).

S. Salvadori, R. Tomatis, R. Rocchi, 2009, International journal of peptide and protein research.

STUDIES ON TRYPSIN INHIBITORS. PART VII. SYNTHESIS OF PROTECTED PEPTIDES RELATED TO SEQUENCE 1-14 AND 36-52 OF PORCINE PANCREATIC SECRETORY TRYPSIN INHIBITOR II (KAZAL)

S. Salvadori, R. Tomatis, R. Rocchi, 1977 .

Solution structure of nociceptin peptides

P. Amodeo, S. Salvadori, P. Temussi, 2002, Journal of peptide science : an official publication of the European Peptide Society.

Antidepressant-like effects of the nociceptin/orphanin FQ receptor antagonist UFP-101: new evidence from rats and mice

S. Salvadori, G. Calo’, R. Guerrini, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Structure- and conformation-activity studies of nociceptin/orphanin FQ receptor dimeric ligands

E. Novellino, S. Salvadori, D. Brancaccio, 2017, Scientific Reports.

Synthesis and biological evaluation of novel pyrazoline-based aromatic sulfamates with potent carbonic anhydrase isoforms II, IV and IX inhibitory efficacy.

C. Supuran, S. Salvadori, G. Balboni, 2018, Bioorganic chemistry.

In vitro and in vivo characterisation of the bifunctional MOP / DOP ligand UFP-505

Lambert, L., S. Salvadori, 2018 .

Hydrogen sulfide induced disruption of Na+ homeostasis in the cortex.

S. Salvadori, D. Chao, G. Balboni, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Na+ mechanism of δ-opioid receptor induced protection from anoxic K+ leakage in the cortex

S. Salvadori, D. Chao, G. Balboni, 2009, Cellular and Molecular Life Sciences.

Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore.

S. Salvadori, G. Balboni, M. Zotti, 2007, Bioorganic & medicinal chemistry.

Identification of an immunodominant IgE epitope of the Parietaria judaica major allergen.

S. Salvadori, M. A. Costa, M. Mirisola, 1998, Journal of immunology.

Involvement of μ-opioid receptors in the modulation of pituitary-adrenal axis in normal and stressed rats

F. Petraglia, S. Salvadori, A. Genazzani, 1995, Journal of endocrinological investigation.

Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent mu/delta-opioid receptor antagonist, regulates obese-related factors in mice.

S. Salvadori, G. Balboni, Ralph E. Wilson, 2009, European journal of pharmacology.

Nociceptin/Orphanin FQ(1-13)NH2 analogues modified in the Phe1-Gly2 peptide bond.

S. Salvadori, G. Calo’, R. Guerrini, 2003, Bioorganic & medicinal chemistry letters.

Bv8/prokineticin 2 is involved in Aβ-induced neurotoxicity

M. Ciotti, S. Salvadori, G. Balboni, 2015, Scientific Reports.

Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain.

A. D'Ursi, S. Salvadori, P. Temussi, 2002, European journal of biochemistry.

No acute effect of naloxone and dermorphin on calcitonin secretion in man.

S. Salvadori, B. Bagni, E. D. Degli Uberti, 1983, The Journal of nuclear medicine and allied sciences.

Further studies on the pharmacological profile of the neuropeptide S receptor antagonist SHA 68

S. Salvadori, C. Cifani, R. Ciccocioppo, 2010, Peptides.

In Vitro and in Vivo Pharmacological Characterization of the Neuropeptide S Receptor Antagonist [d-Cys(tBu)5]Neuropeptide S

S. Salvadori, R. Reinscheid, C. Ruzza, 2009, Journal of Pharmacology and Experimental Therapeutics.

Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice

S. Salvadori, C. Ruzza, G. Calo’, 2008, British journal of pharmacology.

[Nphe1,Arg14,Lys15]Nociceptin‐NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor

S. Salvadori, D. Lambert, M. Morari, 2002, British journal of pharmacology.

Design of μ selective opioid dipeptide antagonists

P. Amodeo, S. Salvadori, G. Balboni, 1997, FEBS letters.

In vitro and in vivo pharmacological characterization of a neuropeptide S tetrabranched derivative

S. Salvadori, R. Reinscheid, C. Ruzza, 2015, Pharmacology research & perspectives.

[ t Bu-d-Gly5]NPS, a pure and potent antagonist of the neuropeptide S receptor: In vitro and in vivo studies

S. Salvadori, C. Ruzza, G. Calo’, 2012, Peptides.

Synthesis and biological activity of human neuropeptide S analogues modified in position 5

S. Salvadori, R. Reinscheid, G. Calo’, 2010 .

Further studies at neuropeptide s position 5: discovery of novel neuropeptide S receptor antagonists.

S. Salvadori, R. Reinscheid, C. Ruzza, 2009, Journal of medicinal chemistry.

Synthesis and biological activity of human neuropeptide S analogues modified in position 5: identification of potent and pure neuropeptide S receptor antagonists.

S. Salvadori, R. Reinscheid, C. Ruzza, 2009, Journal of medicinal chemistry.

Structure-activity study at positions 3 and 4 of human neuropeptide S.

S. Salvadori, R. Reinscheid, C. Ruzza, 2008, Bioorganic & medicinal chemistry.

In vitro and in vivo pharmacological characterization of the neuropeptide S receptor antagonist [ D-Cys ( tBu ) 5 ] NPS

S. Salvadori, R. Reinscheid, C. Ruzza, 2008 .

The Effects of Neuropeptide S on General Anesthesia in Rats

M. Kudo, S. Salvadori, K. Hirota, 2011, Anesthesia and analgesia.

Synthesis and biological activity of human neuropeptide S analogues modified in position 2.

S. Salvadori, R. Reinscheid, C. Ruzza, 2008, Journal of medicinal chemistry.

Conformation-activity relationship of neuropeptide S and some structural mutants: helicity affects their interaction with the receptor.

S. Salvadori, P. Temussi, R. Reinscheid, 2007, Journal of medicinal chemistry.

Critical role for prokineticin 2 in CNS autoimmunity

V. Martinelli, R. Pedotti, L. Steinman, 2015, Neurology: Neuroimmunology & Neuroinflammation.

Mhamad Abou-Hamdan,

V. Martinelli, R. Pedotti, L. Steinman, 2015 .

The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain

I. Screpanti, S. Salvadori, P. Sacerdote, 2009, Proceedings of the National Academy of Sciences.

Structure-activity study of the nociceptin(1-13)-NH2 N-terminal tetrapeptide and discovery of a nociceptin receptor antagonist.

S. Salvadori, G. Calo’, R. Guerrini, 1998, Journal of medicinal chemistry.

Triazine compounds as antagonists at Bv8-prokineticin receptors.

S. Salvadori, G. Balboni, C. Trapella, 2008, Journal of medicinal chemistry.

Prokineticin 2 Upregulation in the Peripheral Nervous System Has a Major Role in Triggering and Maintaining Neuropathic Pain in the Chronic Constriction Injury Model

L. Rodella, S. Salvadori, P. Sacerdote, 2015, BioMed research international.

Halogenated triazinediones behave as antagonists of PKR1: in vitro and in vivo pharmacological characterization

S. Salvadori, G. Balboni, A. Francioso, 2014 .

Prokineticin Receptor 1 Antagonist PC-10 as a Biomarker for Imaging Inflammatory Pain

S. Salvadori, G. Balboni, Xiaoyuan Chen, 2011, The Journal of Nuclear Medicine.

Neuropeptide S selectively inhibits the release of 5‐HT and noradrenaline from mouse frontal cortex nerve endings

L. Raiteri, S. Salvadori, G. Calo’, 2009, British journal of pharmacology.

Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides.

G. Caliendo, V. Santagada, S. Salvadori, 1997, Journal of medicinal chemistry.

HIV-1 protease inhibitors containing a novel C2 symmetrical hydroxyalkylgem-diamino core structure.

S. Salvadori, M. Marastoni, R. Tomatis, 2009, The journal of peptide research : official journal of the American Peptide Society.

Pharmacological profile of hemokinin 1: a novel member of the tachykinin family.

S. Salvadori, G. Calo’, R. Guerrini, 2002, Life sciences.

N-carbamidoyl-4-((3-ethyl-2,4,4-trimethylcyclohexyl)methyl)benzamide enhances staurosporine cytotoxic effects likely inhibiting the protective action of Magmas toward cell apoptosis.

S. Salvadori, R. Guerrini, V. Bertolasi, 2014, Journal of medicinal chemistry.

Urodynamic effects of intravesical nociceptin/orphanin FQ in neurogenic detrusor overactivity: a randomized, placebo-controlled, double-blind study.

M. Spinelli, S. Salvadori, G. Calo’, 2003, Urology.

UFP-101, a peptide antagonist selective for the nociceptin/orphanin FQ receptor.

S. Salvadori, D. Lambert, G. Calo’, 2006, CNS drug reviews.

UFP-101, a Peptide Antagonist Selective for the Nociceptin (cid:1) Orphanin FQ Receptor

S. Salvadori, D. Lambert, G. Calo’, 2005 .

Peptide welding technology – A simple strategy for generating innovative ligands for G protein coupled receptors

S. Salvadori, C. Ruzza, G. Calo’, 2018, Peptides.

A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism

S. Salvadori, G. Calo’, R. Guerrini, 2017, Scientific Reports.

[(pF)Phe4,Arg14,Lys15]N/OFQ-NH2 (UFP-102), a Highly Potent and Selective Agonist of the Nociceptin/Orphanin FQ Receptor

S. Salvadori, D. Lambert, M. Morari, 2005, Journal of Pharmacology and Experimental Therapeutics.

N- and C-terminal modifications of nociceptin/orphanin FQ generate highly potent NOP receptor ligands.

S. Salvadori, D. Lambert, G. Calo’, 2005, Journal of medicinal chemistry.

Pharmacological profile of nociceptin/orphanin FQ receptors regulating 5‐hydroxytryptamine release in the mouse neocortex

S. Salvadori, M. Morari, L. Beani, 2004, The European journal of neuroscience.

Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)NH2 analogues

M. Salis, S. Salvadori, R. Ciccocioppo, 2002, Naunyn-Schmiedeberg's Archives of Pharmacology.

Girolamo Calo ’ Pharmacological characterisation of [ ( pX ) Phe 4 ] nociceptin ( 1-13 ) amide analogues 1 . In vitro studies

Hartmut Berger, Remo Guerrini, Girolamo Calo', 2002 .

Structure-activity studies of the Phe(4) residue of nociceptin(1-13)-NH(2): identification of highly potent agonists of the nociceptin/orphanin FQ receptor.

S. Salvadori, K. Varani, D. Lambert, 2001, Journal of medicinal chemistry.

Girolamo Calo ’ Pharmacological characterisation of [ ( pX ) Phe 4 ] nociceptin ( 1-13 ) NH 2 analogues 2 . In vivo studies

M. Salis, S. Salvadori, R. Ciccocioppo, 2022 .

UFP-101 antagonizes the spinal antinociceptive effects of nociceptin/orphanin FQ: Behavioral and electrophysiological studies in mice

S. Salvadori, G. Calo’, Cristiano Nazzaro, 2007, Peptides.

Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist.

S. Salvadori, D. Lambert, G. Calo’, 2006, Bioorganic & medicinal chemistry.

Structure activity studies of nociceptin/orphanin FQ(1-13)-NH2 derivatives modified in position 5.

S. Salvadori, D. Lambert, G. Calo’, 2015, Bioorganic & medicinal chemistry.

Tryptophan replacement in the nociceptin/orphanin FQ receptor ligand Ac-RYYRWK-NH2.

S. Salvadori, G. Calo’, R. Guerrini, 2008, The journal of peptide research : official journal of the American Peptide Society.

Pain peptides. Solution structure of orphanin FQ2

P. Amodeo, S. Salvadori, P. Temussi, 2000, FEBS letters.

Design, Synthesis, and Biological Characterization of Novel Mitochondria Targeted Dichloroacetate-Loaded Compounds with Antileukemic Activity.

P. Secchiero, G. Zauli, S. Salvadori, 2016, Journal of medicinal chemistry.

Conformational analysis of potent and very selective δ opioid dipeptide antagonists

P. Amodeo, S. Salvadori, G. Balboni, 1995, FEBS letters.

Selective d‐opioid receptor antagonist N,N(CH 3) 2 ‐Dmt‐Tic‐OH does not reduce ethanol intake in alcohol‐preferring AA rats

S. Salvadori, E. Korpi, L. Lazarus, 2003, Addiction biology.

Design and solution structure of a partially rigid opioid antagonist lacking the basic center--models of antagonism.

F. Fraternali, S. Salvadori, G. Balboni, 1997, European journal of biochemistry.

δ‐Selective Opioid Peptides Containing a Single Aromatic Residue in the Message Domain: An NMR Conformational Analysis

P. Amodeo, S. Salvadori, P. Temussi, 1996 .

Probing the shape of a hydrophobic pocket in the active site of δ‐opioid antagonists

G. Caliendo, V. Santagada, E. Perissutti, 2001, Journal of peptide science : an official publication of the European Peptide Society.

Inverse agonism by Dmt-Tic analogues and HS 378, a naltrindole analogue.

S. Salvadori, G. Balboni, R. Guerrini, 2000, European journal of pharmacology.

Dmt-Tic-OH a highly selective and potent delta-opioid dipeptide receptor antagonist after systemic administration in the mouse.

S. Salvadori, G. Balboni, A. Capasso, 1996, Life sciences.

Evaluation of the Dmt-Tic pharmacophore: Conversion of a potent δ-opioid receptor antagonist into a potent δ agonist and ligands with mixed properties

S. Salvadori, G. Balboni, R. Guerrini, 2002 .

Effect of dermorphin on behavior and hippocampal electrical activity in rabbits.

A. Aloisi, S. Salvadori, F. Portaluppi, 1993, Life sciences.

Structure–Activity relationship of tetrapeptides related to dermorphin: A 500‐MHz 1H‐nmr study

S. Salvadori, G. Balboni, P. Temussi, 1988, Biopolymers.

Opioid peptides. Structure-activity relationships in dermorphin pentapeptides III.

S. Salvadori, M. Marastoni, R. Tomatis, 1982, Il Farmaco; edizione scientifica.

Conversion of enkephalin and dermorphin into delta-selective opioid antagonists by single-residue substitution.

P. Amodeo, S. Salvadori, D. Picone, 1994, European journal of biochemistry.

A 500-MHz proton nuclear magnetic resonance study of mu opioid peptides in a simulated receptor environment.

T Tancredi, A. Pastore, S. Salvadori, 1987, Journal of medicinal chemistry.

A conformational study of the opioid peptide dermorphin by one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy.

A. Pastore, S. Salvadori, P. Temussi, 1985, Biophysical journal.

Proton magnetic resonance studies on dermorphin and its peptide fragments

A. Pastore, S. Salvadori, P. Temussi, 1984, Biopolymers.

Synthesis and structure-activity relationships of deltorphin analogues.

S. Salvadori, G. Balboni, M. Morari, 1991, Journal of medicinal chemistry.

New features of the δ opioid receptor : conformational properties of deltorphin I analogues

S. Salvadori, G. Balboni, D. Picone, 1990 .

Synthesis and pharmacological activity of partially modified retro-inverso dermorphin tetrapeptides.

S. Salvadori, G. Balboni, M. Marastoni, 1985, Journal of medicinal chemistry.

SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF PARTIALLY MODIFIED RETRO‐INVERSO DERMORPHIN TETRAPEPTIDES

S. Salvadori, G. Balboni, M. Marastoni, 1985 .

Epitope of the Parietaria judaica Major Allergen Identification of an Immunodominant IgE

S. Salvadori, M. Mirisola, D. Geraci, 2013 .

Identification of an Immunodominant IgE

Remo, S. Salvadori, M. Mirisola, 1998 .

Unique sequence in deltorphin C confers structural requirement for δ opioid receptor selectivity

W. E. Wilson, P. Grieco, S. Salvadori, 1992 .

N-(N-benzyloxycarbonyl-L-1,2,3,4-tetrahydroisoquinol-3-ylcarbonyl)-L-phenylalanine methyl ester, Z-L-Tic-L-Phe-OMe

S. Capasso, S. Salvadori, G. Baldoni, 1994 .

Helix-inducing α-aminoisobutyric acid in opioid mimetic deltorphin C analogues

S. Salvadori, R. Guerrini, S. Bryant, 1997 .

Further studies on the Dmt-Tic pharmacophore: hydrophobic substituents at the C-terminus endow delta antagonists to manifest mu agonism or mu antagonism.

S. Salvadori, G. Balboni, R. Guerrini, 1999, Journal of Medicinal Chemistry.

Selective opioid dipeptides.

P. Amodeo, S. Salvadori, D. Picone, 1994, Biochemical and biophysical research communications.

Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore.

S. Salvadori, G. Balboni, C. Trapella, 2009, Journal of medicinal chemistry.

Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).

S. Salvadori, G. Balboni, R. Guerrini, 2005, Journal of medicinal chemistry.

New delta-opioid antagonists as pharmacological probes.

S. Salvadori, S. Bryant, L. Lazarus, 1998, Trends in pharmacological sciences.

Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth.

Maria Paola Costi, S. Salvadori, G. Ponterini, 2014, Journal of medicinal chemistry.

Opioid receptor selectivity reversal in deltorphin tetrapeptide analogues.

W. E. Wilson, S. Salvadori, L. Lazarus, 1991, Biochemical and biophysical research communications.

Synthesis, pharmacological evaluation and conformational investigation of endomorphin-2 hybrid analogues

S. Salvadori, G. Balboni, A. Sacchetti, 2012, Molecular Diversity.

The novel delta opioid receptor agonist UFP-512 dually modulates motor activity in hemiparkinsonian rats via control of the nigro-thalamic pathway

O. Mabrouk, S. Salvadori, M. Morari, 2009, Neuroscience.

Use of Z-Arg,ω,ω’ (Boc)2-OH and Fmoc-Argω,ω’ (Boc)2-OH in peptide synthesis: Dermorphin and deltorphin-C analogs with Arg residues in the address domain

S. Salvadori, R. Guerrini, G. Fossati, 1993 .

Conformational properties of deltorphin: New features of the δ‐opioid receptor

S. Salvadori, G. Balboni, D. Picone, 1989 .

Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors.

C Bianchi, S. Salvadori, G. Balboni, 1993, Journal of medicinal chemistry.

Para-substituted Phe3 deltorphin analogues: enhanced selectivity of halogenated derivatives for delta opioid receptor sites.

S. Salvadori, L. Lazarus, R. Tomatis, 1992, Journal of Medicinal Chemistry.

New insights on μ/δ selectivity of opioid peptides: Conformational analysis of deltorphin analogues

V. Santagada, P. Amodeo, S. Salvadori, 1991 .

Stress-induced activation of sympathetic nervous system is attenuated by the delta-opioid receptor agonist deltorphin in healthy man.

S. Salvadori, F. Portaluppi, M. Bondanelli, 1993, The Journal of clinical endocrinology and metabolism.

Relationship between receptor affinity and topography of N-terminally extended and bridged [Tyr1-->Asp4]deltorphin C analogues: novel probes for the delta-opioid receptor.

S. Salvadori, P. Temussi, S. Bryant, 1993, European Journal of Pharmacology.

2-Aminoamides and pseudopeptides carrying an amino group common to two residues

S. Salvadori, G. Balboni, L. Lazarus, 1993 .

Molecular Determinants in the Delta Selectivity of Deltorphins

W. E. Wilson, S. Salvadori, L. Lazarus, 1992 .

Conformational properties of analogues of deltorphins

P. Amodeo, S. Salvadori, G. Balboni, 1991 .

Solution structure of deltorphin I at 265 K: a quantitative NMR study.

P. Amodeo, A. Motta, S. Salvadori, 1992, Peptide research.

Differential effects of deltorphin on arginine and galanin-induced growth hormone secretion in healthy man

S. Salvadori, M. Bondanelli, M. Ambrosio, 1995, Regulatory Peptides.

∂-Opioid Receptors and the Secretion of Growth Hormone in Man: Effect of Opioid ∂-Receptor Agonist Deltorphin on GH Responses to GH-Releasing Hormone and Insulin-Induced Hypoglycemia

S. Salvadori, F. Portaluppi, M. Ambrosio, 1992 .

Synthesis, metabolic stability and chemotactic activity of peptide T and its analogues.

S. Salvadori, G. Balboni, R. Gavioli, 2009, International journal of peptide and protein research.

Opioid peptides. Synthesis and binding properties of dermorphin related heptapeptides.

S. Salvadori, G. Balboni, M. Marastoni, 2009, International journal of peptide and protein research.

HIV-1 protease inhibitors containing an N-hydroxyamino acid core structure.

S. Salvadori, M. Marastoni, R. Tomatis, 2001, Bioorganic & medicinal chemistry.

Trypsin-pancreatic secretory isoinhibitor A from bovine pancreas (Kazal type). Spectroscopic study on structure and stability.

S. Salvadori, E. Menegatti, A. Scatturin, 2009, International journal of peptide and protein research.

Dmt-Tic-NH-CH2-Bid (UFP-502), a potent DOP receptor agonist: In vitro and in vivo studies

S. Salvadori, G. Balboni, D. Lambert, 2006, Peptides.

Conformational analysis of an opioid peptide in solvent media that mimic cytoplasm viscosity

A. Motta, S. Salvadori, P. Temussi, 1992, Biopolymers.

6-N,N-Dimethylamino-2,3-naphthalimide: A New Environment-Sensitive Fluorescent Probe in δ- and μ-Selective Opioid Peptides

S. Salvadori, G. Balboni, R. Argazzi, 2006 .

Physicochemical stability of cabazitaxel and docetaxel solutions

S. Salvadori, A. Dalpiaz, R. Guerrini, 2014 .

6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.

S. Salvadori, G. Balboni, R. Argazzi, 2006, Journal of medicinal chemistry.

Dermorphin-induced hyperexcitability in hippocampal CA3 and CA1 in vitro.

S. Salvadori, L. Lazarus, L. Jones, 1994, European journal of pharmacology.

Anxiolytic and antidepressant-like activities of UFP-512, a novel selective delta opioid receptor agonist

S. Salvadori, G. Balboni, D. Lambert, 2006, European Neuropsychopharmacology.

DAILY INTRAVESICAL INSTILLATION OF 1 MG NOCICEPTIN/ ORPHANIN FQ (N/OFQ) FOR THE CONTROL OF NEUROGENIC DETRUSOR OVERACTIVITY -A MULTICENTRE, PLACEBO CONTROLLED, RANDOMISED STUDY

M. Spinelli, S. Salvadori, G. Calo’, 2006 .

Nonpeptide/peptide chimeric ligands for the nociceptin/orphanin FQ receptor: design, synthesis and in vitro pharmacological activity.

S. Salvadori, G. Calo’, R. Guerrini, 2004, The journal of peptide research : official journal of the American Peptide Society.

Acid catalysis in the formation of dioxopiperazines from peptides containing tetrahydroisoquinoline-3-carboxylic acid at position 2.

L. Mazzarella, S. Capasso, F. Sica, 2009, International journal of peptide and protein research.

Pharmacological characterization of nociceptin receptor: an in vitro study.

S. Salvadori, G. Calo’, R. Guerrini, 1997, Canadian journal of physiology and pharmacology.

CLINICAL ENDOCRINOLOGY & METABOLISM

S. Grundy, M. Fillyaw, J. Norton, 1992 .

Solution structure of the Alzheimer's disease amyloid beta-peptide (1-42)

A. D'Ursi, S. Salvadori, P. Temussi, 2003 .

Synthesis and pharmacological activity of a new antagonist of the OP4 receptor

S. Salvadori, G. Calo’, R. Guerrini, 2002 .

Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent mu/delta-opioid receptor antagonist, regulates obese-related factors in mice.

S. Salvadori, G. Balboni, Ralph E. Wilson, 2009, European journal of pharmacology.

Inhibition of the development of morphine tolerance by a potent dual μ-/δ-opioid antagonist, H-Dmt-Tic-Lys-NH-CH2-Ph

S. Salvadori, G. Balboni, L. Lazarus, 2008, Pharmacology Biochemistry and Behavior.

Spontaneous cyclization of the aspartic acid side chain to the succinimide derivative

L. Mazzarella, A. Zagari, S. Capasso, 1992 .

Blockade of Nociceptin/Orphanin FQ Receptor Signaling in Rat Substantia Nigra Pars Reticulata Stimulates Nigrostriatal Dopaminergic Transmission and Motor Behavior

N. Mercuri, G. Franchi, S. Salvadori, 2004, The Journal of Neuroscience.

Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic.

S. Salvadori, G. Balboni, J. Neumeyer, 2011, European journal of medicinal chemistry.

The interaction of highly helical structural mutants with the NOP receptor discloses the role of the address domain of nociceptin/orphanin FQ.

S. Salvadori, P. Temussi, G. Calo’, 2005, Chemistry.

Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth.

Maria Paola Costi, S. Salvadori, G. Ponterini, 2014, Journal of medicinal chemistry.

Peptides and proteins in a confined environment: NMR spectra at natural isotopic abundance

A. Pastore, S. Salvadori, P. Temussi, 2007, Journal of peptide science : an official publication of the European Peptide Society.

Opioid Diketopiperazines: Refinement of the δ Opioid Antagonist Pharmacophore

S. Salvadori, G. Balboni, R. Guerrini, 1997, Biological chemistry.

The effects of dermorphin on the endocrine system in man

S. Salvadori, G. Trasforini, A. Margutti, 1985, Peptides.

Opioidmimetic peptides containing α-aminoisobutyric acid

S. Salvadori, R. Guerrini, S. Bryant, 2002 .

Design and Synthesis of 1-Aminocycloalkane-1-carboxylic Acid-Substituted Deltorphin Analogues: Unique δ and μ Opioid Activity in Modified Peptides

S. Salvadori, R. Guerrini, S. Bryant, 1996 .

Crystal structures of dipeptides containing the Dmt-Tic pharmacophore.

J. Deschamps, C. George, J. Flippen-Anderson, 2002, Journal of medicinal chemistry.

A cyclic peptide T analogue with high chemotactic activity

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