C. Holt

发表

Primary and predicted secondary structures of the caseins in relation to their biological functions.

C. Holt, L. Sawyer, 1988, Protein engineering.

Co-adsorption of beta-casein and calcium phosphate nanoclusters (CPN) at hydrophilic and hydrophobic solid-solution interfaces studied by neutron reflectometry

C. Holt, T. Nylander, G. Fragneto, 2011 .

Effect of Phosphorylation on a Human-like Osteopontin Peptide

C. Holt, S. Lenton, T. Nylander, 2017, Biophysical journal.

Measurement of particle sizes by elastic and quasi-elastic light scattering.

D. Dalgleish, C. Holt, T. G. Parker, 1975, Biochimica et biophysica acta.

The secondary structure of milk proteins and their biological function.

C. Holt, L. Sawyer, Lindsay Sawyer, 1993, Journal of dairy science.

Caseins as rheomorphic proteins: interpretation of primary and secondary structures of the αS1-, β- and κ-caseins

Lindsay Sawyer, Carl Holt, C. Holt, 1993 .

Substructure of bovine casein micelles by small-angle X-ray and neutron scattering

C. G. D. Kruif, C. Holt, R. Tuinier, 2003 .

Composition and structure of micellar calcium phosphate

D. Hukins, C. Holt, L. Sawyer, 1989, Journal of Dairy Research.

Conversion of amorphous calcium phosphate into hydroxyapatite investigated by EXAFS spectroscopy

D. Hukins, C. Holt, J. Harries, 1987 .

Preparation of amorphous calcium-magnesium phosphates at pH 7 and characterization by x-ray absorption and fourier transform infrared spectroscopy

D. Hukins, C. Holt, J. Harries, 1988 .

Casein Micelle Structure, Functions and Interactions

C. Holt, C. Kruif, 2003 .

Measurements of the size of bovine casein micelles by means of electron microscopy and light Scattering

B. Brooker, C. Holt, J. Prentice, 1978 .

Functional and dysfunctional folding, association and aggregation of caseins.

J. Carver, C. Holt, 2019, Advances in protein chemistry and structural biology.

Unfolded phosphopolypeptides enable soft and hard tissues to coexist in the same organism with relative ease.

C. Holt, 2013, Current opinion in structural biology.

Natural variations in the average size of bovine casein micelles: II. Milk samples from creamery bulk silos in south west Scotland

C. Holt, D. Muir, 1978 .

Inorganic constituents of milk III. The colloidal calcium phosphate of cow's milk

C. Holt, 1982, Journal of Dairy Research.

Mineralisation of soft and hard tissues and the stability of biofluids.

C. Holt, S. Lenton, T. Nylander, 2014, Journal of structural biology.

The composition of milk.

C. Holt, W. Christie, T. Mepham, 1983 .

Sequence characteristics responsible for protein-protein interactions in the intrinsically disordered regions of caseins, amelogenins, and small heat-shock proteins.

J. Carver, C. Holt, J. Raynes, 2019, Biopolymers.

Electrophoretic and hydrodynamic properties of bovine casein micelles interpreted in terms of particles with an outer hairy layer

D. Dalgleish, C. Holt, 1986 .

Interrelationships of the concentrations of some ionic constituents of human milk and comparison with cow and goat milks.

C. Holt, 1993, Comparative biochemistry and physiology. Comparative physiology.

A quantitative model of the bovine casein micelle: ion equilibria and calcium phosphate sequestration by individual caseins in bovine milk

C. Holt, T. Huppertz, H. V. van Valenberg, 2018, European Biophysics Journal.

Some physico-chemical properties of nine commercial or semi-commercial whey protein concentrates, isolates and fractions

H. Molinari, G. Kontopidis, R. Ipsen, 1999 .

Are casein micelles extracellular condensates formed by liquid‐liquid phase separation?

M. Vendruscolo, J. Carver, M. Fuxreiter, 2022, FEBS letters.

Structural studies of hydrated samples of amorphous calcium phosphate and phosphoprotein nanoclusters

C. Holt, L. Sawyer, S. Lenton, 2016, European Biophysics Journal.

Adsorption of β‐Lactoglobulin variants A and B to the air–water interface

C. Holt, P. Wilde, A. Mackie, 1999 .

Amyloid fibril formation by αS1- and β-casein implies that fibril formation is a general property of all casein proteins.

J. Carver, M. Sunde, C. Holt, 2022, Biochimica et biophysica acta. Proteins and proteomics.

Proteostasis and the Regulation of Intra- and Extracellular Protein Aggregation by ATP-Independent Molecular Chaperones: Lens α-Crystallins and Milk Caseins.

J. Carver, R. Truscott, C. Holt, 2018, Accounts of chemical research.

Multifunctional role of osteopontin in directing intrafibrillar mineralization of collagen and activation of osteoclasts.

Douglas E. Rodriguez, L. Gower, C. Holt, 2014, Acta biomaterialia.

Apparent chemical composition of nine commercial or semi-commercial whey protein concentrates, isolates and fractions

H. Molinari, G. Kontopidis, R. Ipsen, 1999 .

Invited review: beta-lactoglobulin: binding properties, structure, and function.

G. Kontopidis, C. Holt, L. Sawyer, 2004, Journal of dairy science.

Phosphopeptide dissociation from micellar calcium phosphate preparations does not induce crystallinity

D. Hukins, C. Holt, L. S. Nelson, 1989, Journal of Dairy Research.

A review of the biology of calcium phosphate sequestration with special reference to milk

C. Holt, S. Lenton, T. Nylander, 2014, Dairy science & technology.

Role of calcium phosphate nanoclusters in the control of calcification

C. Holt, E. S. Sørensen, R. Clegg, 2009, The FEBS journal.

Expression of recombinant wild‐type and mutant β‐Lactoglobulins in the yeast Pichia pastoris

D. Flint, L. Quarrie, C. Holt, 1999 .

The effect of transglutaminase treatment on the physico-chemical properties of skim milk with added ethylenediaminetetraacetic acid

C. Holt, Y. Hemar, D. Otter, 2017 .

Depletion interaction of casein micelles and an exocellular polysaccharide.

C. Holt, R. Tuinier, P. Timmins, 1999, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.

A core-shell model of calcium phosphate nanoclusters stabilized by beta-casein phosphopeptides, derived from sedimentation equilibrium and small-angle X-ray and neutron-scattering measurements.

C. Holt, P. Timmins, J. Leaver, 1998, European journal of biochemistry.

A comparison of silver ion HPLC plus GC with Fourier‐transform IR spectroscopy for the determination of trans double bonds in unsaturated fatty acids

T. G. Toschi, C. Holt, W. Christie, 1993 .

The degradation of [14C]molinate in soil under flooded and nonflooded conditions.

C. Holt, V. M. Thomas, 1980, Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.

Casein structures in the context of unfolded proteins

J. Carver, C. Holt, H. Ecroyd, 2015 .

A recombinant C121S mutant of bovine beta-lactoglobulin is more susceptible to peptic digestion and to denaturation by reducing agents and heating.

C. Holt, L. Sawyer, T. Haertlé, 2004, Biochemistry.

Amorphous calcium phosphates prepared at pH 6.5 and 6.0

D. Hukins, C. Holt, J. Harries, 1989 .

Analysis of EXAFS spectra from the brushite and monetite forms of calcium phosphate

D. Hukins, C. Holt, J. Harries, 1987 .

A biological perspective on the structure and function of caseins and casein micelles

C. Holt, E. Smyth, R. Clegg, 2004 .

Salt partition, ion equilibria, and the structure, composition, and solubility of micellar calcium phosphate in bovine milk with added calcium salts.

C. Holt, T. Nylander, Qian Wang, 2020, Journal of dairy science.

A quantitative model of the bovine casein micelle: ion equilibria and calcium phosphate sequestration by individual caseins in bovine milk

C. Holt, T. Huppertz, H. V. van Valenberg, 2018, European Biophysics Journal.

Milk Salts | Interaction with Caseins

C. Holt, 2011 .

An equilibrium thermodynamic model of the sequestration of calcium phosphate by casein micelles and its application to the calculation of the partition of salts in milk

C. Holt, 2004, European Biophysics Journal.

MILK SALTS AND THEIR INTERACTION WITH CASEINS

C. Holt, 2002 .

The Milk Salts: Their Secretion, Concentrations and Physical Chemistry

C. Holt, 1985 .

Interrelationships of constituents and partition of salts in milk samples from eight species.

C. Holt, R. Jenness, 1984, Comparative biochemistry and physiology. A, Comparative physiology.

The inorganic constituents of milk IV. Diffusible calcium and magnesium concentrations in goat's milk and the effect of starvation

C. Holt, P. C. Thomas, I. Ormrod, 1982, Journal of Dairy Research.

Calculation of the ion equilibria in milk diffusate and comparison with experiment.

D. Dalgleish, C. Holt, R. Jenness, 1981, Analytical biochemistry.

Inorganic constituents of milk: I. Correlation of soluble calcium with citrate in bovine milk

C. Holt, D. Muir, 1979, Journal of Dairy Research.

Structural Biology of Calcium Phosphate Nanoclusters Sequestered by Phosphoproteins

C. Holt, S. Lenton, T. Nylander, 2020, Crystals.

Fourier transform infrared spectroscopy and characterisation of biological calcium phosphates

C. Holt, R. Bailey, 1989 .

An equilibrium thermodynamic model of the sequestration of calcium phosphate by casein phosphopeptides

C. Holt, E. M. Little, 2004, European Biophysics Journal.

Calcium environment in encrusting deposits from urinary catheters investigated by interpretation of EXAFS spectra.

D. Hukins, C. Holt, J. Harries, 1989, Journal of inorganic biochemistry.

BIOLOGICAL CALCIFICATION : INVESTIGATION BY X-RAY ABSORPTION SPECTROSCOPY

D. Hukins, C. Holt, J. Harries, 1986 .

Comparison of the structure of micellar calcium phosphate in milk from six species by extended X-ray absorption fine structure spectroscopy

D. Hukins, C. Holt, J. C. Irlam, 1985, Journal of Dairy Research.

Influence of Phosphoproteins on Calcification

D. Hukins, C. Holt, S. Hasnain, 1984 .

Structure of bovine milk calcium phosphate determined by X-ray absorption spectroscopy.

D. Hukins, C. Holt, S. Hasnain, 1982, Biochimica et biophysica acta.

Ability of a beta-casein phosphopeptide to modulate the precipitation of calcium phosphate by forming amorphous dicalcium phosphate nanoclusters.

C. Holt, T. Drakenberg, N. M. Wahlgren, 1996, The Biochemical journal.

The interaction of phosphoproteins with calcium phosphate

C. Holt, M. V. Kemenade, 1989 .

Invited review: Caseins and the casein micelle: their biological functions, structures, and behavior in foods.

J. Carver, C. Holt, H. Ecroyd, 2013, Journal of dairy science.

Effect of heating and cooling on the milk salts and their interaction with casein

C. Holt, 1995 .

Application of Ion Chromatography to the Characterization of Biological Calcium Phosphates

D. Hukins, C. Holt, J. Harries, 1987 .

Structure and stability of bovine casein micelles.

C. Holt, 1992, Advances in protein chemistry.

Structural analysis of the environment of calcium ions in crystalline and amorphous calcium phosphates by X-ray absorption spectroscopy and a hypothesis concerning the biological function of the casein micelle

D. Hukins, C. Holt, 1991 .

Quantitative multivalent binding model of the structure, size distribution and composition of the casein micelles of cow milk

C. Holt, J. Carver, 2021, International Dairy Journal.

Invited Review: β-Lactoglobulin: Binding Properties, Structure, and Function

Lindsay Sawyer, George Kontopidis, Carl Holt, 2004 .

Native disulphide-linked dimers facilitate amyloid fibril formation by bovine milk αS2-casein.

Glyn L. Devlin, P. Hoffmann, J. Carver, 2020, Biophysical chemistry.

Swelling of Golgi vesicles in mammary secretory cells and its relation to the yield and quantitative composition of milk.

C. Holt, 1983, Journal of theoretical biology.

Effect of the free energies of formation of the core and shell and of the density of the casein phosphate centres on the thermodynamic stability of calcium phosphate nanoclusters

C. Holt, 2004 .

Amorphous calcium phosphates of different composition give very similar EXAFS spectra

D. Hukins, C. Holt, J. Harries, 1989 .

Casein and casein micelle structures, functions and diversity in 20 species

C. Holt, 2016 .

Darwinian transformation of a ‘scarcely nutritious fluid’ into milk

J. Carver, C. Holt, Carl Holt, 2012, Journal of evolutionary biology.

The hairy casein micelle: evolution of the concept and its implications for dairy technology

C. Holt, D. Horne, 1996 .

Thermal denaturation of beta-lactoglobulin: effect of protein concentration at pH 6.75 and 8.05.

C. Holt, S. Brownlow, P. Sellers, 1995, Biochimica et biophysica acta.

Effect of temperature on the secondary structure of beta-lactoglobulin at pH 6.7, as determined by CD and IR spectroscopy: a test of the molten globule hypothesis.

X L Qi, D. Clarke, C. Holt, 1997, The Biochemical journal.

A quantitative calcium phosphate nanocluster model of the casein micelle: the average size, size distribution and surface properties

C. Holt, 2021, European Biophysics Journal.

Effects of colloidal calcium phosphate content and free calcium ion concentration in the milk serum on the dissociation of bovine casein micelles

C. Holt, A. Law, D. Davies, 1986, Journal of Dairy Research.

Some Principles Determining Salt Composition and Partitioning of Ions in Milk

C. Holt, 1981 .

Small-angle neutron scattering of aggregated whey protein colloids with an exocellular polysaccharide

C. Holt, C. Kruif, R. Tuinier, 2000 .

Cortisol, parathyroid hormone-related protein and the onset of calcium secretion by the mammary gland of the goat

C. Holt, A. Care, G. Thompson, 1997, Journal of Dairy Research.

Casein and lactose concentrations in milk of 31 species are negatively correlated

C. Holt, R. Jenness, 1987, Experientia.

Insertion of a casein kinase recognition sequence induces phosphorylation of ovine beta-lactoglobulin in transgenic mice.

A. Clark, C. Holt, E. Hitchin, 1999, Protein engineering.

Natural variations in the average size of bovine casein micelles: III. Studies on colostrum by electron by microscopy and light scattering

B. Brooker, C. Holt, 1978, Journal of Dairy Research.

Erratum to: “Milk protein structure—what can it tell the dairy industry?”

G. Jameson, G. Kontopidis, P. Barlow, 2002 .

A geometrical model to describe the initial aggregation of partly renneted casein micelles

D. Dalgleish, C. Holt, 1988 .

The Size Distribution of Bovine Casein Micelles: A Review

C. Holt, 1985 .

Aggregation behavior of bovine κ- and β-casein studied with small angle neutron scattering, light scattering, and cryogenic transmission electron microscopy.

C. Holt, S. Lenton, T. Nylander, 2012, Langmuir : the ACS journal of surfaces and colloids.

The ligand-binding site of bovine beta-lactoglobulin: evidence for a function?

Lindsay Sawyer, George Kontopidis, Carl Holt, 2002, Journal of molecular biology.

Dynamic footprint of sequestration in the molecular fluctuations of osteopontin

G. Zaccai, C. Holt, S. Lenton, 2015, Journal of The Royal Society Interface.

A Raman optical activity study of rheomorphism in caseins, synucleins and tau. New insight into the structure and behaviour of natively unfolded proteins.

Ewan W Blanch, Michel Goedert, Lutz Hecht, 2002, European journal of biochemistry.

Caseins as Rheomorphic Proteins : Interpretation of Primary and Secondary Structures of the asl-, p = and Ic-caseins

Lindsay Sawyer, Carl Holt, C. Holt, 1993 .

Post-secretory aggregation of caseins.

B. Brooker, C. Holt, 1979, The Journal of dairy research.

The EXAFS spectra of poorly crystalline calcium phosphate preparations from heated milk

D. Hukins, C. Holt, L. S. Nelson, 1989 .

Seasonal changes in the heat stability of milk from creamery silos in south-west Scotland

C. Holt, A. Sweetsur, D. Muir, 1978, Journal of Dairy Research.

Casein Micelle Substructure and Calcium Phosphate Interactions Studied by Sephacryl Column Chromatography

C. Holt, 1998 .

Natural variations in the average size of bovine casein micelles: I. Milks from individual Ayrshire cows

C. Holt, L. Baird, 1978, Journal of Dairy Research.

Inorganic constituents of cheese: analysis of juice from a one-month-old Cheddar cheese and the use of light and electron microscopy to characterize the crystalline phases

B. Brooker, C. Holt, H. Morris, 1988, Journal of Dairy Research.

The heat stability of milk and concentrated milk containing added aldehydes and sugars

C. Holt, A. Sweetsur, D. Muir, 1978, Journal of Dairy Research.

Review Milk protein structureFwhat can it tell the dairy industry

G. Jameson, G. Kontopidis, P. Barlow, 2002 .

Milk protein structure-what can it tell the dairy industry?(vol 12, pg 299, 2002)

G. Jameson, G. Kontopidis, P. Barlow, 2002 .

Comparison of the Effect of Heating on the Thermal Denaturation of Nine Different β-Lactoglobulin Preparations of Genetic Variants A, B or A/B, as Measured by Microcalorimetry

C. Holt, J. Maubois, J. Fauquant, 1998 .

Physicochemical Study of κ- and β-Casein Dispersions and the Effect of Cross-Linking by Transglutaminase

C. Holt, C. Kruif, R. Tuinier, 2002 .

EFFECT OF FINISH‐FRYING CONDITIONS ON THE QUALITY OF FRENCH FRIED POTATOES

C. Holt, Janusz M. Zak, 1973 .

Physicochemical Study of K - and (cid:226) -Casein Dispersions and the Effect of Cross-Linking by Transglutaminase

C. Holt, P. Timmins, R. Tuinier, 2022 .

Casein micelle size from elastic and quasi-elastic light scattering measurements.

C. Holt, 1975, Biochimica et biophysica acta.

An E. coli over-expression system for multiply-phosphorylated proteins and its use in a study of calcium phosphate sequestration by novel recombinant phosphopeptides.

C. Holt, R. Clegg, 2009, Protein expression and purification.

Molecular basis of whey protein food functionalities.

C. Holt, 2000 .

Structural studies of hydrated samples of amorphous calcium phosphate and phosphoprotein nanoclusters

C. Holt, L. Sawyer, S. Lenton, 2016, European Biophysics Journal.

Structural Studies on Bovine Casein Micelles by Laser Light Scattering

C. Holt, 1983 .

Discrimination among Bacillus cereus, B. mycoides and B. thuringiensis and some other species of the genus Bacillus by Fourier transform infrared spectroscopy.

A G Williams, C. Holt, C. Holt, 1998, FEMS microbiology letters.

Beta-casein adsorption at the silicon oxide-aqueous solution interface: calcium ion effects.

C. Holt, T. Nylander, F. Tiberg, 2004, Biomacromolecules.

MILK PROTEINS: BIOLOGICAL AND FOOD ASPECTS OF STRUCTURE AND FUNCTION

C. Holt, Z. Sikorski, H. Rogin´ski, 2001 .

Mineralisation of soft and hard tissues and the stability of biofluids.

C. Holt, S. Lenton, T. Nylander, 2014, Journal of structural biology.

Role of calcium phosphate nanoclusters in the control of calcification

C. Holt, E. S. Sørensen, R. Clegg, 2009, The FEBS journal.