J. Dean

发表

Crystallization of the NADP(+)-dependent glutamate dehydrogenase from Escherichia coli.

J. Wootton, T. Attwood, A. North, 1993, Journal of molecular biology.

The Intracellular Signaling Pathways of Inflammatory Stress

J. Dean, J. Saklatvala, A. Clark, 2002 .

NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling.

P. Evans, J. Dean, L. Rawlinson, 2008, The Journal of biological chemistry.

Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment.

O. Fedorov, W. Yue, O. Gileadi, 2017, Journal of molecular biology.

Gain-of-Function Mutation of Tristetraprolin Impairs Negative Feedback Control of Macrophages In Vitro yet Has Overwhelmingly Anti-Inflammatory Consequences In Vivo

M. Ridley, J. Dean, C. Buckley, 2017, Molecular and Cellular Biology.

Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression

G. Kollias, H. Perlman, M. Vitek, 2016, Annals of the rheumatic diseases.

PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression.

P. Blackshear, Francesco P. Marchese, N. Mackman, 2014, Blood.

MAPKAP Kinase 2 Blocks Tristetraprolin-directed mRNA Decay by Inhibiting CAF1 Deadenylase Recruitment

Francesco P. Marchese, J. Dean, J. Saklatvala, 2010, The Journal of Biological Chemistry.

The p38 MAPK pathway inhibits tristetraprolin‐directed decay of interleukin‐10 and pro‐inflammatory mediator mRNAs in murine macrophages

P. Blackshear, M. Gaestel, Francesco P. Marchese, 2009, FEBS letters.

Mitogen-Activated Protein Kinase p38 Controls the Expression and Posttranslational Modification of Tristetraprolin, a Regulator of Tumor Necrosis Factor Alpha mRNA Stability

K. Mahtani, J. Dean, J. Saklatvala, 2001, Molecular and Cellular Biology.

A p38 MAP kinase inhibitor regulates stability of interleukin‐1‐induced cyclooxygenase‐2 mRNA

J. Dean, J. Saklatvala, A. Clark, 1998, FEBS letters.

The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation.

J. Dean, J. Saklatvala, A. Clark, 2004, Cellular signalling.

Heat shock protein‐27 and sex‐selective regulation of muscarinic and proteinase‐activated receptor 2‐mediated vasodilatation: differential sensitivity to endothelial NOS inhibition

M. Hollenberg, K. Mihara, J. Dean, 2018, British journal of pharmacology.

LipopolysaccharideMacrophage Responses to Tristetraprolin Cooperate To Regulate Dual-Specificity Phosphatase 1 and

M. Ridley, J. Dean, A. Ammit, 2015 .

Destabilizing Protein Tristetraprolin Targeted Mutation of the mRNA Dominant Suppression of Inflammation via

J. Dean, N. Morrice, C. Monaco, 2015 .

HSP25 Vaccination Attenuates Atherogenesis via Upregulation of LDLR Expression, Lowering of PCSK9 Levels and Curbing of Inflammation

J. Dean, Jingwen Liu, W. Gerthoffer, 2021, Arteriosclerosis, thrombosis, and vascular biology.

Heat Shock Protein 27 Immune Complex Upregulates LDLR Expression Thereby Reducing Plasma Cholesterol and Atherogenesis

J. Dean, Jingwen Liu, W. Gerthoffer, 2020, bioRxiv.

Selective Tumor Necrosis Factor Receptor I Blockade Is Antiinflammatory and Reveals Immunoregulatory Role of Tumor Necrosis Factor Receptor II in Collagen‐Induced Arthritis

M. Feldmann, J. Dean, K. Blazek, 2014, Arthritis & rheumatology.

Identification of a novel AU-rich-element-binding protein which is related to AUF1.

J. Dean, R. Wait, L. Rawlinson, 2002, The Biochemical journal.

The 3′ Untranslated Region of Tumor Necrosis Factor Alpha mRNA Is a Target of the mRNA-Stabilizing Factor HuR

K. Mahtani, J. Dean, R. Wait, 2005, Molecular and Cellular Biology.

Treatment of in ﬂ ammatory arthritis via targeting of tristetraprolin, a master regulator of pro-in ﬂ ammatory gene expression

G. Kollias, H. Perlman, M. Vitek, 2017 .

TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-κB pathways and signals TRAF2 protein degradation in macrophages.

M. Feldmann, J. Dean, Richard O. Williams, 2014, Cellular signalling.

Toll-Like Receptor Signaling Pathways in Macrophages Downstream of α Cross Talk between the Akt and p38

M. Gaestel, N. Leslie, J. Dean, 2013 .

Cross Talk between the Akt and p 38 Pathways in Macrophages Downstream of Toll-Like Receptor Signaling

M. Gaestel, S. O'keefe, I. Batty, 2013 .

Control of the expression of inflammatory response genes.

J. Dean, J. Saklatvala, A. Clark, 2003, Biochemical Society symposium.

The p38 MAPK pathway mediates both antiinflammatory and proinflammatory processes: comment on the article by Damjanov and the editorial by Genovese.

J. Dean, J. Saklatvala, A. Clark, 2009, Arthritis and rheumatism.

Cross Talk between the Akt and p38α Pathways in Macrophages Downstream of Toll-Like Receptor Signaling

Mark Boothby, M. Gaestel, J. Arthur, 2013, Molecular and Cellular Biology.

The catalytic role of aspartate in the active site of glutamate dehydrogenase.

K. Britton, T. J. Stillman, D. Rice, 1994, The Biochemical journal.

p38 Mitogen-activated Protein Kinase Regulates Cyclooxygenase-2 mRNA Stability and Transcription in Lipopolysaccharide-treated Human Monocytes*

J. Dean, J. Saklatvala, A. Clark, 1999, The Journal of Biological Chemistry.

Heat Shock Protein 27 Functions in Inflammatory Gene Expression and Transforming Growth Factor-β-activated Kinase-1 (TAK1)-mediated Signaling*

J. Dean, L. Rawlinson, J. Saklatvala, 2007, Journal of Biological Chemistry.

Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for Deubiquitination

P. Evans, M. Ashcroft, J. Dean, 2013, Circulation research.

The p38 MAPK Pathway in Rheumatoid Arthritis: A Sideways Look

J. Dean, A. Clark, 2012, The open rheumatology journal.

p38 Mitogen-activated Protein Kinase Stabilizes mRNAs That Contain Cyclooxygenase-2 and Tumor Necrosis Factor AU-rich Elements by Inhibiting Deadenylation*

J. Dean, J. Saklatvala, Jeremy Saklatvala, 2003, Journal of Biological Chemistry.

Hydrogen Peroxide Prolongs Nuclear Localization of NF-κB in Activated Cells by Suppressing Negative Regulatory Mechanisms*

I. Adcock, P. Evans, J. Dean, 2008, Journal of Biological Chemistry.

The control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatases

J. Dean, A. Clark, 2016, Biochemical Society transactions.

The 3′ Untranslated Region of Tumor Necrosis Factor Alpha mRNA Is a Target of the mRNA-Stabilizing Factor HuR

K. Mahtani, J. Dean, R. Wait, 2001, Molecular and Cellular Biology.

Post-transcriptional gene regulation by MAP kinases via AU-rich elements.

J. Dean, J. Saklatvala, A. Clark, 2009, Frontiers in bioscience.

Protein kinase cascades in intracellular signalling by interleukin-I and tumour necrosis factor.

J. Dean, J. Saklatvala, A. Finch, 1999, Biochemical Society symposium.

Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin

A. Cunningham, J. Dean, N. Morrice, 2015, The Journal of Immunology.

Identification of a novel AUrich-element-binding protein which is related to AUF 1

Clark, K. Tomer, S. Bell, 2011 .

Heat Shock Protein B1-Deficient Mice Display Impaired Wound Healing

Xin Lu, J. Dean, J. Saklatvala, 2013, PloS one.

MSK1 and MSK2 Inhibit Lipopolysaccharide-Induced Prostaglandin Production via an Interleukin-10 Feedback Loop

P. Blackshear, A. Reith, J. Arthur, 2013, Molecular and Cellular Biology.

Loop Production via an Interleukin-10 Feedback Lipopolysaccharide-Induced Prostaglandin MSK 1 and MSK 2 Inhibit

Alastair, P. Blackshear, S. Arthur, 2013 .

Structural and functional dissection of a conserved destabilizing element of cyclo-oxygenase-2 mRNA: evidence against the involvement of AUF-1 [AU-rich element/poly(U)-binding/degradation factor-1], AUF-2, tristetraprolin, HuR (Hu antigen R) or FBP1 (far-upstream-sequence-element-binding protein 1).

J. Dean, R. Wait, L. Rawlinson, 2004, The Biochemical journal.

Post‐transcriptional regulation of gene expression by mitogen‐activated protein kinase p38

J. Dean, J. Saklatvala, A. Clark, 2003, FEBS letters.

Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation

N. Gray, Wuyuan Lu, J. Dean, 2016, Proceedings of the National Academy of Sciences.

Alteration of the quaternary structure of glutamate dehydrogenase from Clostridium symbiosum by a single mutation distant from the subunit interfaces

D. Rice, S. Harding, P. Engel, 1997, European Biophysics Journal.

Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide

M. Ridley, J. Dean, A. Ammit, 2015, The Journal of Immunology.

Spontaneous chemical reversion of an active site mutation: deamidation of an asparagine residue replacing the catalytic aspartic acid of glutamate dehydrogenase.

P. Engel, J. Dean, K. Geoghegan, 2005, Biochemistry.