T. Jensen

发表

Allosteric modulation balances thermodynamic stability and restores function of ΔF508 CFTR.

Pradeep Kota, Nikolay V Dokholyan, Santiago Reyes, 2012, Journal of molecular biology.

Restoration of domain folding and interdomain assembly by second‐site suppressors of the ΔF508 mutation in CFTR

Kenneth L. Nesbitt, J. Riordan, Lihua He, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Synthesis and cellular studies of PEG-functionalized meso-tetraphenylporphyrins.

M. Vicente, T. Jensen, Martha Sibrian-Vazquez, 2007, Journal of photochemistry and photobiology. B, Biology.

Peptide-mediated cell transport of water soluble porphyrin conjugates.

R. P. Hammer, M. Vicente, T. Jensen, 2006, Journal of medicinal chemistry.

Synthesis and characterization of positively charged porphyrin-peptide conjugates.

R. P. Hammer, M. Vicente, T. Jensen, 2005, Bioconjugate chemistry.

Synthesis and cellular studies of nonaggregated water-soluble phthalocyanines.

Kevin M. Smith, R. P. Hammer, Kevin M Smith, 2005, Journal of medicinal chemistry.

Cryo-EM visualization of an active high open probability CFTR ion channel

J. Riordan, James Z. Chen, A. Aleksandrov, 2018, bioRxiv.

Correctors of ΔF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein

J. Riordan, N. Dokholyan, P. Kota, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites.

J. Riordan, N. Alon, T. Jensen, 1993, The Journal of biological chemistry.

Removal of multiple arginine-framed trafficking signals overcomes misprocessing of delta F508 CFTR present in most patients with cystic fibrosis.

J. Riordan, L. Cui, A. Aleksandrov, 1999, Molecular cell.

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

J. Riordan, Liying Cui, T. Jensen, 1998, The EMBO journal.

Seminaphthofluorones are a family of water-soluble, low molecular weight, NIR-emitting fluorophores

I. Warner, R. Strongin, T. Jensen, 2008, Proceedings of the National Academy of Sciences.

Effect of overall charge and charge distribution on cellular uptake, distribution and phototoxicity of cationic porphyrins in HEp2 cells.

Kevin M. Smith, Kevin M Smith, Jolanna A. Norton, 2010, Journal of photochemistry and photobiology. B, Biology.

Phosphatase inhibitors activate normal and defective CFTR chloride channels.

L. Tsui, J. Rommens, M. Buchwald, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis of porphyrin-carbohydrate conjugates using "click" chemistry and their preliminary evaluation in human HEp2 cells

Erhong Hao, M. Vicente, T. Jensen, 2009 .

Enhanced cellular uptake with a cobaltacarborane-porphyrin-HIV-1 Tat 48-60 conjugate.

Erhong Hao, M. Vicente, T. Jensen, 2006, Bioconjugate chemistry.

Synthesis and in vitro properties of trimethylamine- and phosphonate-substituted carboranylporphyrins for application in BNCT.

M. Vicente, T. Jensen, F. Fronczek, 2008, Bioorganic & medicinal chemistry.

Single-dose pharmacokinetics of aerosol MP-376 (levofloxacin solution for inhalation) in cystic fibrosis patients: PK-PD implications

K. Bostian, T. Jensen, M. Dudley, 2008 .

Influence of the number and distribution of NLS peptides on the photosensitizing activity of multimeric porphyrin-NLS.

M. Vicente, T. Jensen, Martha Sibrian-Vazquez, 2010, Organic & biomolecular chemistry.

The cystic fibrosis mutation (delta F508) does not influence the chloride channel activity of CFTR.

J. Rommens, T. Jensen, C. Bear, 1993, Nature genetics.

Inhibition of the 1,25-dihydroxyvitamin D3-induced increase in vitamin D receptor (VDR) levels and binding of VDR-retinoid X receptor (RXR) to a direct repeat (DR)-3 type response element by an RXR-specific ligand in human keratinocyte cultures.

T. Jensen, K. Kragballe, H. Sølvsten, 1998, Biochemical pharmacology.

Syntheses, properties and cellular studies of metalloisoporphyrins.

Kevin M. Smith, Kevin M Smith, M. Vicente, 2011, Journal of porphyrins and phthalocyanines.

Regulatory insertion removal restores maturation, stability and function of DeltaF508 CFTR.

Pradeep Kota, Nikolay V Dokholyan, Lihua He, 2010, Journal of molecular biology.

An organic white light-emitting fluorophore.

I. Warner, R. Strongin, T. Jensen, 2006, Journal of the American Chemical Society.

Mitochondria targeting by guanidine- and biguanidine-porphyrin photosensitizers.

M. Vicente, I. Nesterova, T. Jensen, 2008, Bioconjugate chemistry.

Prejunctional modulation by prostaglandin E2 of noradrenaline release from sympathetic neurones in rabbit aorta.

T. Jensen, O. Nedergaard, 1997, Pharmacology & toxicology.

Mislocalization of ΔF508 CFTR in cystic fibrosis sweat gland

J. Riordan, T. Jensen, A. Naismith, 1992, Nature Genetics.

The DeltaF508 mutation results in loss of CFTR function and mature protein in native human colon.

J. Riordan, T. Jensen, K. Kunzelmann, 2004, Gastroenterology.

Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator

J. Riordan, G. Lukács, S. Sidhu, 2016, mAbs.

The cystic fibrosis mutation (ΔF508) does not influence the chloride channel activity of CFTR

Johanna M. Rommens, Canhui Li, Christine E. Bear, 1993, Nature Genetics.

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

J. Riordan, T. Jensen, R. Bridges, 1992, Cell.

Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance

L. Tsui, J. Riordan, J. Rommens, 1991, Cell.

Mislocalization of delta F508 CFTR in cystic fibrosis sweat gland.

J. Riordan, T. Jensen, A. Naismith, 1992, Nature genetics.

Transformed sweat gland and nasal epithelial cell lines from control and cystic fibrosis individuals.

J. Riodan, J. Buchanan, M. Buchwald, 1990, Journal of cell science.

Regulation of the cystic fibrosis transmembrane conductance regulator anion channel by tyrosine phosphorylation

J. Riordan, T. Jensen, J. Hanrahan, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Potential sites of CFTR activation by tyrosine kinases

J. Riordan, T. Jensen, X. Chang, 2016, Channels.

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

J. Riordan, A. Goldberg, T. Jensen, 1995, Cell.

Role of N-linked oligosaccharides in the biosynthetic processing of the cystic fibrosis membrane conductance regulator

J. Riordan, A. Aleksandrov, Liying Cui, 2008, Journal of Cell Science.

The effect of meconium exposure on the expression and differentiation of amniotic fluid mesenchymal stem cells

C. Finck, T. Jensen, J. Shui, 2017, Journal of neonatal-perinatal medicine.

Determination of CFTR chloride channel activity and pharmacology using radiotracer flux methods.

J. Riordan, R. Dérand, G. Heda, 2004, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Syntheses and properties of a series of cationic water-soluble phthalocyanines.

M. Vicente, T. Jensen, Hairong Li, 2008, Journal of medicinal chemistry.

Personalised medicine for non-classic cystic fibrosis resulting from rare CFTR mutations

A. Aleksandrov, T. Jensen, M. Gentzsch, 2020, European Respiratory Journal.

Synthesis and cellular studies of a carboranylchlorin for the PDT and BNCT of tumors.

Kevin M. Smith, Kevin M Smith, M. Vicente, 2006, Bioorganic & medicinal chemistry.

Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel.

J. Riordan, James Z. Chen, A. Aleksandrov, 2018, Biochemistry.

Targeted Proteomic Quantitation of the Absolute Expression and Turnover of Cystic Fibrosis Transmembrane Conductance Regulator in the Apical Plasma Membrane

J. Riordan, X. Yao, T. Jensen, 2014, Journal of proteome research.

Modulation of norepinephrine release from sympathetic neurons of the rabbit aorta by prejunctional prostanoid receptors.

T. Jensen, O. Nedergaard, 1999, The Journal of pharmacology and experimental therapeutics.

Conformational Variability in Ground-State CFTR Lipoprotein Particle Cryo-EM Ensembles

T. Jensen, L. Aleksandrov, J. Strauss, 2022, International journal of molecular sciences.

Thermal stability of purified and reconstituted CFTR in a locked open channel conformation.

J. Riordan, A. Aleksandrov, Lihua He, 2015, Protein expression and purification.

Cryo-EM visualization of an active high open probability CFTR anion channel

J. Riordan, James Z. Chen, A. Aleksandrov, 2018 .

Mapping of cystic fibrosis transmembrane conductance regulator membrane topology by glycosylation site insertion.

T. Jensen, X. Chang, J. Riordan, 1994, The Journal of biological chemistry.

Role of individual R domain phosphorylation sites in CFTR regulation by protein kinase A.

J. Riordan, A. Aleksandrov, Liying Cui, 2009, Biochimica et biophysica acta.

Dibasic protein kinase A sites regulate bursting rate and nucleotide sensitivity of the cystic fibrosis transmembrane conductance regulator chloride channel

J. Riordan, T. Jensen, X. Chang, 1998, The Journal of physiology.

Erratum: Correctors of dF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein (FASEB Journal (2013) 27 (536 -545) DOI:10.1096/fj.12-216119)

J. Riordan, N. Dokholyan, P. Kota, 2014 .

Early life of cystic fibrosis transmembrane conductance regulator (CFTR) in the cell

J. Riordan, T. Jensen, M. Gentzsch, 2001 .

Syntheses and cellular studies of water soluble porphyrin-peptide conjugates

Robert P. Hammer, Martha Sibrian-Vazquez, Timothy J. Jensen, 2007, SPIE BiOS.

Correctors of F508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein

N. Dokholyan, P. Kota, A. Aleksandrov, 2014 .

Synthesis and cellular studies of porphyrin-cobaltacarborane conjugates.

Erhong Hao, M. Vicente, T. Jensen, 2005, Bioconjugate chemistry.

Synthesis and in vitro properties of trimethylamine- and phosphonate-substituted carboranylporphyrins for application in BNCT.

M. Vicente, T. Jensen, F. Fronczek, 2008, Bioorganic & medicinal chemistry.

Potential sites of CFTR activation by tyrosine kinases

J. Riordan, T. Jensen, X. Chang, 2016, Channels.