L. Aleksandrov

发表

Allosteric modulation balances thermodynamic stability and restores function of ΔF508 CFTR.

Pradeep Kota, Nikolay V Dokholyan, Santiago Reyes, 2012, Journal of molecular biology.

Restoration of domain folding and interdomain assembly by second‐site suppressors of the ΔF508 mutation in CFTR

Kenneth L. Nesbitt, J. Riordan, Lihua He, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cryo-EM visualization of an active high open probability CFTR ion channel

J. Riordan, James Z. Chen, A. Aleksandrov, 2018, bioRxiv.

Structure of the cystic fibrosis transmembrane conductance regulator in the inward-facing conformation revealed by single particle electron microscopy

J. Riordan, L. Aleksandrov, R. Ford, 2015 .

Differential Interactions of Nucleotides at the Two Nucleotide Binding Domains of the Cystic Fibrosis Transmembrane Conductance Regulator*

J. Riordan, A. Aleksandrov, L. Aleksandrov, 2001, The Journal of Biological Chemistry.

The role of cystic fibrosis transmembrane conductance regulator phenylalanine 508 side chain in ion channel gating

J. Riordan, A. Aleksandrov, Liying Cui, 2006, The Journal of physiology.

Domain interdependence in the biosynthetic assembly of CFTR.

Andrei Aleksandrov, Lihua He, J. Riordan, 2007, Journal of molecular biology.

R-Domain Phosphorylation by Protein Kinase A Stimulates Dissociation of Unhydrolyzed ATP from the First Nucleotide-Binding Site of the Cystic Fibrosis Transmembrane Conductance Regulator.

J. Riordan, L. Aleksandrov, J. Fay, 2018, Biochemistry.

Architecture of the cystic fibrosis transmembrane conductance regulator protein and structural changes associated with phosphorylation and nucleotide binding.

J. Riordan, L. Aleksandrov, R. Ford, 2009, Journal of structural biology.

Mg2+ -dependent ATP occlusion at the first nucleotide-binding domain (NBD1) of CFTR does not require the second (NBD2).

J. Riordan, A. Aleksandrov, L. Aleksandrov, 2008, The Biochemical journal.

The First Nucleotide Binding Domain of Cystic Fibrosis Transmembrane Conductance Regulator Is a Site of Stable Nucleotide Interaction, whereas the Second Is a Site of Rapid Turnover*

J. Riordan, A. Aleksandrov, L. Aleksandrov, 2002, The Journal of Biological Chemistry.

Regulatory insertion removal restores maturation, stability and function of DeltaF508 CFTR.

Pradeep Kota, Nikolay V Dokholyan, Lihua He, 2010, Journal of molecular biology.

Purification and Crystallization of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)*

J. Riordan, L. Aleksandrov, R. Ford, 2004, Journal of Biological Chemistry.

Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains

J. Riordan, L. DeLucas, J. Kappes, 2014, Protein science : a publication of the Protein Society.

Nucleoside triphosphate pentose ring impact on CFTR gating and hydrolysis

A. Aleksandrov, L. Aleksandrov, Luba A. Aleksandrov, 2002, FEBS letters.

CFTR (ABCC7) is a hydrolyzable-ligand-gated channel

Andrei A. Aleksandrov, John R. Riordan, J. Riordan, 2007, Pflügers Archiv - European Journal of Physiology.

Multiple Membrane-Cytoplasmic Domain Contacts in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mediate Regulation of Channel Gating*

Nikolay V. Dokholyan, Adrian W. R. Serohijos, Andrei A. Aleksandrov, 2008, Journal of Biological Chemistry.

The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

J. Riordan, L. Aleksandrov, R. Ford, 2011, The Journal of Biological Chemistry.

Domain location within the cystic fibrosis transmembrane conductance regulator protein investigated by electron microscopy and gold labelling.

J. Riordan, L. Aleksandrov, R. Ford, 2011, Biochimica et biophysica acta.

Functional analysis of the C-terminal boundary of the second nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator and structural implications.

J. Riordan, A. Aleksandrov, M. Gentzsch, 2002, The Biochemical journal.

Crystallographic and single-particle analyses of native- and nucleotide-bound forms of the cystic fibrosis transmembrane conductance regulator (CFTR) protein.

J. Riordan, L. Aleksandrov, R. Ford, 2005, Biochemical Society transactions.

Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel.

J. Riordan, James Z. Chen, A. Aleksandrov, 2018, Biochemistry.

Conformational Variability in Ground-State CFTR Lipoprotein Particle Cryo-EM Ensembles

T. Jensen, L. Aleksandrov, Luba A. Aleksandrov, 2022, International journal of molecular sciences.

Thermal stability of purified and reconstituted CFTR in a locked open channel conformation.

J. Riordan, A. Aleksandrov, Lihua He, 2015, Protein expression and purification.

Cryo-EM visualization of an active high open probability CFTR anion channel

J. Riordan, James Z. Chen, A. Aleksandrov, 2018 .

The non‐hydrolytic pathway of cystic fibrosis transmembrane conductance regulator ion channel gating

J. Riordan, A. Aleksandrov, L. Aleksandrov, 2000, The Journal of physiology.