G. Obmolova

发表

Design of novel FN3 domains with high stability by a consensus sequence approach.

Jinquan Luo, Gary L Gilliland, Galina Obmolova, 2012, Protein engineering, design & selection : PEDS.

Two routes for production and purification of Fab fragments in biopharmaceutical discovery research: Papain digestion of mAb and transient expression in mammalian cells.

G. Obmolova, L. Gutshall, Yonghong Zhao, 2009, Protein expression and purification.

Inexpensive robotic system for standard and fluorescent imaging of protein crystals.

G. Obmolova, Dakota Handzlik, Eric Larson, 2019, Acta crystallographica. Section F, Structural biology communications.

Protein crystallization with microseed matrix screening: application to human germline antibody Fabs

G. Gilliland, A. Teplyakov, G. Obmolova, 2014, Acta crystallographica. Section F, Structural biology communications.

Promoting crystallization of antibody–antigen complexes via microseed matrix screening

G. Gilliland, A. Teplyakov, G. Obmolova, 2010, Acta crystallographica. Section D, Biological crystallography.

Crystal structure of the Escherichia coli YcdX protein reveals a trinuclear zinc active site

Gary L Gilliland, Galina Obmolova, Alexey Teplyakov, 2003, Proteins.

Crystal structure of inorganic pyrophosphatase from Thermus thermophilus

K S Wilson, K. Wilson, A. Teplyakov, 1994, Protein Science.

The structure of deoxy- and oxy-leghaemoglobin from lupin.

G G Dodson, B. Vainshtein, G. Obmolova, 1995, Journal of molecular biology.

Channeling of ammonia in glucosamine-6-phosphate synthase.

A Teplyakov, A. Teplyakov, G. Obmolova, 2001, Journal of molecular biology.

DNA mismatch repair: from structure to mechanism.

C. Ban, P. Hsieh, G. Obmolova, 2000, Cold Spring Harbor symposia on quantitative biology.

Human framework adaptation of a mouse anti-human IL-13 antibody.

G. Gilliland, Shanrong Zhao, G. Raghunathan, 2010, Journal of molecular biology.

Crystal structure of the YjeE protein from Haemophilus influenzae: A putative Atpase involved in cell wall synthesis

N. Thanki, G. Gilliland, E. Eisenstein, 2002, Proteins.

Structural insights into humanization of anti-tissue factor antibody 10H10

G. Gilliland, G. Raghunathan, J. C. Almagro, 2018, mAbs.

Structural diversity in a human antibody germline library

G. Gilliland, J. C. Almagro, Jinquan Luo, 2016, mAbs.

Crystal structure of human germline antibody 3-23/B3.

G. Gilliland, J. C. Almagro, A. Teplyakov, 2011, Molecular immunology.

Crystal structure of dephospho-coenzyme A kinase from Haemophilus influenzae.

G. Gilliland, E. Eisenstein, A. Howard, 2001, Journal of structural biology.

The mechanism of sugar phosphate isomerization by glucosamine 6‐phosphate synthase

G. Obmolova, A. Teplyakov, M. Badet-Denisot, 2008, Protein science : a publication of the Protein Society.

Molecular cloning, expression, and site-directed mutagenesis of inorganic pyrophosphatase from Thermus thermophilus HB8.

A. Teplyakov, G. Obmolova, Y. Takahashi, 1998, Journal of biochemistry.

Crystallization of a challenging antigen-antibody complex: TLR3 ECD with three noncompeting Fabs.

G. Gilliland, Jinquan Luo, A. Teplyakov, 2011, Acta Crystallographica. Section F : Structural Biology and Crystallization Communications.

Three-dimensional structure of lipoamide dehydrogenase from Pseudomonas fluorescens at 2.8 A resolution. Analysis of redox and thermostability properties.

W. Hol, K. H. Kalk, G. Obmolova, 1993, Journal of molecular biology.

The binding of carbon monoxide and nitric oxide to leghaemoglobin in comparison with other haemoglobins.

G. Obmolova, A. Popov, I. Kuranova, 1996, Journal of molecular biology.

A coiled conformation of amyloid-β recognized by antibody C706

G. Gilliland, A. Teplyakov, G. Obmolova, 2017, Alzheimer's Research & Therapy.

Crystal structure of tissue factor in complex with antibody 10H10 reveals the signaling epitope.

G. Gilliland, A. Teplyakov, G. Obmolova, 2017, Cellular signalling.

Expression, refolding and purification of a human interleukin-17A variant.

J. F. Nemeth, G. Obmolova, T. Malia, 2011, Cytokine.

Crystal structure of inorganic pyrophosphatase from Thermus thermophilus

K. Wilson, G. Obmolova, I. Kuranova, 1994, Protein science : a publication of the Protein Society.

Crystallization and preliminary X-ray studies of D-serine dehydratase from Escherichia coli.

G. Obmolova, E. Harutyunyan, K. Schnackerz, 1990, Journal of molecular biology.

Induced conformational change in human IL‐4 upon binding of a signal‐neutralizing DARPin

G. Gilliland, S. Jacobs, K. O'Neil, 2015, Proteins.

Crystallization and preliminary X-ray analysis of the two domains of glucosamine-6-phosphate synthase from Escherichia coli.

G. Obmolova, A. Teplyakov, M. Badet-Denisot, 1994, Journal of molecular biology.

Kinetic characterization of a thermostable inorganic pyrophosphatase from Thermus thermophilus.

G. Obmolova, W. Höhne, I. Kuranova, 1988, Biomedica biochimica acta.

From Lobry de Bruyn to enzyme-catalyzed ammonia channelling: molecular studies of D-glucosamine-6P synthase.

A. Teplyakov, G. Obmolova, M. Badet-Denisot, 2002, Natural product reports.

Substrate binding is required for assembly of the active conformation of the catalytic site in Ntn amidotransferases: evidence from the 1.8 A crystal structure of the glutaminase domain of glucosamine 6-phosphate synthase.

I. Polikarpov, J. Littlechild, M. Isupov, 1996, Structure.

Involvement of the C terminus in intramolecular nitrogen channeling in glucosamine 6-phosphate synthase: evidence from a 1.6 A crystal structure of the isomerase domain.

I. Polikarpov, A. Teplyakov, G. Obmolova, 1998, Structure.

Crystal structure of carboxypeptidase T from Thermoactinomyces vulgaris.

N. Grishin, A. Osterman, O. Galperina, 1992, European journal of biochemistry.

Engineering of microheterogeneity‐resistant p‐hydroxybenzoate hydroxylase from Pseudomonas fluorescens

W. Hol, K. H. Kalk, G. Obmolova, 1990, FEBS letters.

Crystal structure of apo-neocarzinostatin at 0.15-nm resolution.

K. Wilson, A. Teplyakov, G. Obmolova, 1993, European journal of biochemistry.

Crystal structure of bacteriophage T4 deoxynucleotide kinase with its substrates dGMP and ATP.

A Teplyakov, K S Wilson, A Perrakis, 1996, The EMBO journal.

Epitope mapping of anti-interleukin-13 neutralizing antibody CNTO607.

G. Gilliland, K. O'Neil, Jinquan Luo, 2009, Journal of molecular biology.

Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring.

W. Hol, K. H. Kalk, H. Schreuder, 1994, Biochemistry.

Crystallographic analysis of substrate binding and catalysis in dihydrolipoyl transacetylase (E2p).

W. Hol, K. H. Kalk, A. Teplyakov, 1993, Biochemistry.

Structural basis for high selectivity of anti-CCL2 neutralizing antibody CNTO 888.

Gary L Gilliland, Galina Obmolova, Raymond Sweet, 2012, Molecular immunology.

Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA

Wei Yang, Galina Obmolova, Changill Ban, 2000, Nature.

The crystal structures of eukaryotic phosphofructokinases from baker's yeast and rabbit skeletal muscle.

M. Radermacher, G. Obmolova, W. Rypniewski, 2011, Journal of molecular biology.

Structural basis for the dual recognition of IL-12 and IL-23 by ustekinumab.

Jinquan Luo, Galina Obmolova, Alexey Teplyakov, 2010, Journal of molecular biology.

Coevolution of antibody stability and Vκ CDR-L3 canonical structure.

Jinquan Luo, Gary L Gilliland, Galina Obmolova, 2010, Journal of molecular biology.

Crystal structure of B‐cell co‐receptor CD19 in complex with antibody B43 reveals an unexpected fold

G. Gilliland, Jinquan Luo, A. Teplyakov, 2018, Proteins.

Efficient expression, purification and crystallisation of two hyperthermostable enzymes of histidine biosynthesis

M. Wilmanns, R. Thoma, R. Sterner, 1999, FEBS letters.

The refined crystal structure of Pseudomonas putida lipoamide dehydrogenase complexed with NAD+ at 2.45 Å resolution

C. Betzel, W. Hol, G. Obmolova, 1992, Proteins.

Composite active site of an ABC ATPase: MutS uses ATP to verify mismatch recognition and authorize DNA repair.

P. Hsieh, Wei Yang, G. Obmolova, 2001, Molecular cell.

Lateral clustering of TLR3:dsRNA signaling units revealed by TLR3ecd:3Fabs quaternary structure.

Z. Zhou, G. Gilliland, Jinquan Luo, 2012, Journal of molecular biology.

Atomic structure of the cubic core of the pyruvate dehydrogenase multienzyme complex.

W. Hol, K. H. Kalk, G. Obmolova, 1993, Science.

Structure of the EMMPRIN N‐terminal domain 1: Dimerization via β‐strand swapping

G. Gilliland, Jinquan Luo, A. Teplyakov, 2009, Proteins.

Crystal Structure of the YchF Protein Reveals Binding Sites for GTP and Nucleic Acid

G. Gilliland, E. Eisenstein, A. Howard, 2003, Journal of bacteriology.

His‐tag binding by antibody C706 mimics β‐amyloid recognition

G. Gilliland, A. Teplyakov, G. Obmolova, 2011, Journal of molecular recognition : JMR.

Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin

Jinquan Luo, Galina Obmolova, Andrew B. Ward, 2018, Science.

IgG2 Fc structure and the dynamic features of the IgG CH2-CH3 interface.

G. Gilliland, A. Teplyakov, G. Obmolova, 2013, Molecular immunology.

Crystal Structure of the YgfZ Protein from Escherichia coli Suggests a Folate-Dependent Regulatory Role in One-Carbon Metabolism

G. Gilliland, O. Herzberg, A. Howard, 2004, Journal of bacteriology.

Disruption of the helix-u-turn-helix motif of MutS protein: loss of subunit dimerization, mismatch binding and ATP hydrolysis.

P. Hsieh, Wei Yang, G. Obmolova, 2001, Journal of molecular biology.

Antibody modeling assessment II. Structures and models

Alexey Teplyakov, Jinquan Luo, Sreekumar Kodangattil, 2014, Proteins.

Refined crystal structure of the catalytic domain of dihydrolipoyl transacetylase (E2p) from Azotobacter vinelandii at 2.6 A resolution.

W. Hol, K. H. Kalk, G. Obmolova, 1993, Journal of molecular biology.

Crystal structure of D-serine dehydratase from Escherichia coli.

Z. Dauter, S. Antonyuk, G. Kachalova, 2012, Biochimica et biophysica acta.

Structural insights into chemokine CCL17 recognition by antibody M116

G. Gilliland, A. Teplyakov, G. Obmolova, 2017, Biochemistry and biophysics reports.

A coiled conformation of amyloid-β recognized by antibody C706

G. Gilliland, A. Teplyakov, G. Obmolova, 2017, Alzheimer's Research & Therapy.

Crystal structure of CD27 in complex with a neutralizing noncompeting antibody

G. Gilliland, A. Teplyakov, G. Obmolova, 2017, Acta crystallographica. Section F, Structural biology communications.

Structural evidence for a constrained conformation of short CDR‐L3 in antibodies

Jinquan Luo, Gary L Gilliland, Galina Obmolova, 2014, Proteins.

Synthesis by native chemical ligation and crystal structure of human CCL2

G. Gilliland, J. F. Nemeth, A. Teplyakov, 2010, Biopolymers.

Bmc Structural Biology Crystal Structure of the Yffb Protein from Pseudomonas Aeruginosa Suggests a Glutathione-dependent Thiol Reductase Function

Z. Dauter, G. Gilliland, O. Herzberg, 2022 .

Epitope‐dependent mechanisms of CD27 neutralization revealed by X‐ray crystallography

G. Gilliland, A. Teplyakov, G. Obmolova, 2017, Molecular immunology.

Conformational flexibility of an anti-IL-13 DARPin†

G. Gilliland, S. Jacobs, K. O'Neil, 2016, Protein engineering, design & selection : PEDS.

Noncanonical conformation of CDR L1 in the anti-IL-23 antibody CNTO4088.

G. Gilliland, A. Teplyakov, G. Obmolova, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystal Structure of the Bacterial YhcH Protein Indicates a Role in Sialic Acid Catabolism

Michael Y. Galperin, G. Gilliland, A. Teplyakov, 2005, Journal of bacteriology.

Induced conformational change in human IL‐4 upon binding of a signal‐neutralizing DARPin

G. Gilliland, S. Jacobs, K. O'Neil, 2015, Proteins: Structure, Function, and Bioinformatics.

Surface salt bridges contribute to the extreme thermal stability of an FN3‐like domain from a thermophilic bacterium

G. Gilliland, S. Jacobs, Sandeep Somani, 2021, Proteins.

Preliminary crystallographic study of cyclohexadienyl dehydratase from Pseudomonas aeruginosa.

R. Jensen, A. Teplyakov, G. Obmolova, 1993, Journal of Molecular Biology.

Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site

Gary L Gilliland, Galina Obmolova, Alexey Teplyakov, 2003 .

C‐terminal β‐strand swapping in a consensus‐derived fibronectin Type III scaffold

G. Gilliland, S. Jacobs, K. O'Neil, 2014, Proteins.

N‐terminal β‐strand swapping in a consensus‐derived alternative scaffold driven by stabilizing hydrophobic interactions

G. Gilliland, S. Jacobs, K. O'Neil, 2014, Proteins.

The catalytic domain of the dihydrolipoyl transacetylase component of the pyruvate dehydrogenase complex from Azotobacter vinelandii and Escherichia coli. Expression, purification, properties and preliminary X-ray analysis.

W. Hol, G. Obmolova, A. Mattevi, 1991, European journal of biochemistry.

The crystal structures of eukaryotic phosphofructokinases from baker's yeast and rabbit skeletal muscle.

M. Radermacher, G. Obmolova, W. Rypniewski, 2011, Journal of molecular biology.

Antigen recognition by antibody C836 through adjustment of V(L)/V(H) packing.

G. Gilliland, A. Teplyakov, G. Obmolova, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystal structure of the YajQ protein from Haemophilus influenzae reveals a tandem of RNP-like domains

G. Gilliland, A. Howard, A. Teplyakov, 2004, Journal of Structural and Functional Genomics.