D. Wraith

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A hazardous vapour trail from abattoir to neuropathy clinic

H. Willison, D. Wraith, 2010, The Lancet Neurology.

CD4+ T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1*1501 mice.

C. Lubich, D. Wraith, Maurus de la Rosa, 2012, Blood.

hemophilic E17 HLA-DRB1*1501 mice intravenously and subcutaneously applied human FVIII in humanized T-cell epitopes associated with antibody responses after + CD4

C. Lubich, D. Wraith, H. Schwarz, 2012 .

Encephalitogenic epitopes of myelin basic protein, proteolipid protein, myelin oligodendrocyte glycoprotein for experimental allergic encephalomyelitis induction in Biozzi ABH (H-2Ag7) mice share an amino acid motif.

P. Travers, D. Wraith, D. Baker, 1996, Journal of immunology.

Nr4a1 and Nr4a3 Reporter Mice Are Differentially Sensitive to T Cell Receptor Signal Strength and Duration

D. Bending, K. Toellner, D. Wraith, 2020, Cell reports.

Distinct regulation of Nr4a receptors by NFAT and ERK signalling during T cell activation

D. Bending, D. Wraith, M. Ono, 2019 .

Differential Nr4a1 and Nr4a3 expression discriminates tonic from activated TCR signalling events in vivo

D. Bending, K. Toellner, D. Wraith, 2019 .

Therapies for Long COVID in non-hospitalised individuals: from symptoms, patient-reported outcomes and immunology to targeted therapies (The TLC Study)

E. Sapey, J. Lord, T. Taverner, 2022, BMJ Open.

Regulatory T Cells + CD25+ CD4Regulatory Function to Naturally Occurring Express Foxp3 but Have Comparable IL-10-Secreting Regulatory T Cells Do Not

B. Stockinger, D. Wraith, A. Boonstra, 2004 .

IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation

E. Hill, D. Wraith, J. Verhagen, 2017, Scientific Reports.

Immunological properties of foreign peptides in multiple display on a filamentous bacteriophage.

R. Perham, D. Wraith, A. Willis, 1993, Gene.

Mite asthma. Cause and management.

D. Wraith, K. Maunsell, A. Hughes, 1970, The Practitioner.

Antigen-specific immunotherapy with apitopes suppresses generation of FVIII inhibitor antibodies in HLA-transgenic mice

D. Wraith, Katrien Pletinckx, K. Nicolson, 2021, Blood advances.

CD86 Has Sustained Costimulatory Effects on CD8 T Cells1

L. Wen, F. Wong, R. Flavell, 2007, The Journal of Immunology.

Experimental autoimmune encephalomyelitis in mice expressing the autoantigen MBP 1-10 covalently bound to the MHC class II molecule I-Au.

D. Wraith, B. Liliensiek, G. Hämmerling, 2006, International immunology.

Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP

N. Viner, L. Fugger, D. Wraith, 2002, Nature Immunology.

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

U. Utz, A. Waisman, D. Mitchell, 1996, Nature.

TGF-β-dependent induction of CD4⁺CD25⁺Foxp3⁺ Tregs by liver sinusoidal endothelial cells.

T. Korn, J. Herkel, A. Lohse, 2014, Journal of hepatology.

Role of MHC Polymorphism in Autoimmune Disease

H. Mcdevitt, L. Steinman, D. Wraith, 1989 .

The Mechanism of Action of Antigen Processing Independent T Cell Epitopes Designed for Immunotherapy of Autoimmune Diseases

E. Hill, D. Wraith, A. Wegner, 2021, Frontiers in Immunology.

Manipulating antigen presentation for antigen-specific immunotherapy of autoimmune diseases

D. Wraith, H. Streeter, 2021, Current opinion in immunology.

Antigen-Specific Immunotherapy for Treatment of Autoimmune Liver Diseases

D. Wraith, Sky T. H. Ng, N. Richardson, 2020, Frontiers in Immunology.

Antigen-Specific Immunotherapy with Thyrotropin Receptor Peptides in Graves' Hyperthyroidism: A Phase I Study

R. Murray, S. Pearce, D. Wraith, 2019, Thyroid : official journal of the American Thyroid Association.

Effects of ATX-MS-1467 immunotherapy over 16 weeks in relapsing multiple sclerosis

B. Sharrack, D. Wraith, J. Chataway, 2017, Neurology.

CNS infection safety signal of RTS,S/AS01 and possible association with rabies vaccine

B. Gessner, D. Wraith, A. Finn, 2016, The Lancet.

Lowering the tone: mechanisms of immunodominance among epitopes with low affinity for MHC.

D. Wraith, P. Fairchild, 1996, Immunology today.

Peptide-based therapy for autoimmune diseases

D. Wraith, 2006 .

Affinity for class II MHC determines the extent to which soluble peptides tolerize autoreactive T cells in naive and primed adult mice--implications for autoimmunity.

D. Wraith, G. Liu, George Y. Liu, 1995, International immunology.

Hierarchy in the ability of T cell epitopes to induce peripheral tolerance to antigens from myelin

D. Wraith, S. Anderton, 1998, European journal of immunology.

Kinetics of Peptide Uptake and Tissue Distribution Following a Single Intranasal Dose of Peptide

D. Wraith, S. Anderton, B. Metzler, 2000, Immunological investigations.

Complete characterization of the expressed immune response genes in Biozzi AB/H mice: structural and functional identity between AB/H and NOD A region molecules

A. Cooke, F. Figueroa, D. Wraith, 2004, Immunogenetics.

Intranasal peptide-induced peripheral tolerance: the role of IL-10 in regulatory T cell function within the context of experimental autoimmune encephalomyelitis.

D. Wraith, S. Anderton, A. Sundstedt, 2002, Veterinary immunology and immunopathology.

A LAT-Based Signaling Complex in the Immunological Synapse as Determined with Live Cell Imaging Is Less Stable in T Cells with Regulatory Capability

E. Hill, F. Fallah-Arani, D. Wraith, 2021, Cells.

Tr1-Like T Cells – An Enigmatic Regulatory T Cell Lineage

D. Wraith, A. M. White, 2016, Front. Immunol..

Isolation and characterization of human interleukin-10-secreting T cells from peripheral blood.

D. Wraith, John D. M. Campbell, G. Mazza, 2010, Human immunology.

Phenotypic analysis of CTLA-4 and CD28 expression during transient peptide-induced T cell activation in vivo.

D. Wraith, C. Burkhart, B. Metzler, 1999, International immunology.

Natural and Induced Regulatory T Cells

D. Wraith, A. Sundstedt, G. Mazza, 2004, Annals of the New York Academy of Sciences.

Role for IL-10 in Suppression Mediated by Peptide-Induced Regulatory T Cells In Vivo 1

D. Wraith, A. Sundstedt, E. O’Neill, 2003, The Journal of Immunology.

Preclinical models of arthritis for studying immunotherapy and immune tolerance

D. Wraith, G. Nagy, D. Tough, 2021, Annals of the Rheumatic Diseases.

Extra‐thymically induced T regulatory cell subsets: the optimal target for antigen‐specific immunotherapy

D. Wraith, J. Verhagen, A. Wegner, 2015, Immunology.

CTLA-4 Modulates the Differentiation of Inducible Foxp3+ Treg Cells but IL-10 Mediates Their Function in Experimental Autoimmune Encephalomyelitis

D. Wraith, J. Verhagen, L. Gabryšová, 2014, PloS one.

Comment on “Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells”

D. Wraith, J. Verhagen, 2010, The Journal of Immunology.

Induction of Tolerance to Therapeutic Proteins With Antigen-Processing Independent T Cell Epitopes: Controlling Immune Responses to Biologics

D. Wraith, E. Schurgers, 2021, Frontiers in Immunology.

A role for galanin in human and experimental inflammatory demyelination

T. Kilpatrick, H. Butzkueven, D. Wraith, 2009, Proceedings of the National Academy of Sciences.

Antigen-presenting cell activation: a link between infection and autoimmunity?

D. Wraith, S. Anderton, S. Kissler, 2001, Journal of autoimmunity.

Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy

J. Gough, D. Wraith, S. Strobel, 2014, Nature Communications.

SARS-CoV-2 Spike- and Nucleoprotein-Specific Antibodies Induced After Vaccination or Infection Promote Classical Complement Activation

I. Henderson, M. Drayson, A. Cunningham, 2022, Frontiers in Immunology.

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

D. M. Smith, K. Okkenhaug, V. De Rosa, 2018, Immunity.

Peptide-MHC interaction in autoimmunity.

D. Wraith, P. Fairchild, 1992, Current opinion in immunology.

Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10.

D. Wraith, George Y. Liu, S. Anderton, 1999, International immunology.

MHC-binding peptides for immunotherapy of experimental autoimmune disease.

D. Wraith, D. Smilek, S. Webb, 1992, Journal of autoimmunity.

T cell recognition in experimental autoimmune encephalomyelitis: prospects for immune intervention with synthetic peptides.

H. Mcdevitt, D. Mitchell, L. Steinman, 1990, International reviews of immunology.

The role of polymorphic I-Ak beta chain residues in presentation of a peptide from myelin basic protein

H. Mcdevitt, J. Buerstedde, D. Wraith, 1989, The Journal of experimental medicine.

Advancement of antigen-specific immunotherapy: knowledge transfer between allergy and autoimmunity

D. Wraith, N. Richardson, 2021, Immunotherapy advances.

for Their Growth, Differentiation, and Are Independent of CD25+ Regulatory Cells Antigen-Induced IL-10+ Regulatory T Cells

D. Wraith, A. Sundstedt, E. O’Neill, 2013 .

Antigen-specific immunotherapy of autoimmune and allergic diseases

D. Wraith, J. Verhagen, C. Sabatos-Peyton, 2010, Current opinion in immunology.

Antigen-Induced IL-10+ Regulatory T Cells Are Independent of CD25+ Regulatory Cells for Their Growth, Differentiation, and Function1

D. Wraith, S. Minaee, A. Sundstedt, 2006, The Journal of Immunology.

CD 25 Regulatory T Cells + Antigen-Induced IL-10

D. Wraith, S. Minaee, A. Sundstedt, 2006 .

Antigen-specific tolerance induction and the immunotherapy of experimental autoimmune disease.

D. Wraith, S. Anderton, C. Burkhart, 1998, Novartis Foundation symposium.

Antigen‐specific immunotherapy of autoimmune disease: a commentary

D. Wraith, D. Wraith, 1996, Clinical and experimental immunology.

Mucosal Tolerance in a Murine Model of Experimental Autoimmune Encephalomyelitis a

D. Wraith, B. Metzler, 1996, Annals of the New York Academy of Sciences.

Antagonism Repertoire: Implications for TCR Fine Specificity of the Myelin-Reactive T Cell

D. Wraith, S. Anderton, C. Burkhart, 1998 .

Differential activation of signal transducer and activator of transcription (STAT)3 and STAT5 and induction of suppressors of cytokine signalling in T(h)1 and T(h)2 cells.

D. Wraith, P. Anderson, A. Sundstedt, 2003, International immunology.

Therapeutic peptide vaccines for treatment of autoimmune diseases.

D. Wraith, 2009, Immunology letters.

Peptide allergen‐specific immunotherapy for allergic airway diseases—State of the art

D. Wraith, M. Krishna, 2021, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Cells In Vitro CD 28 / B 7-Mediated Costimulation on Naive T Qualitative and Quantitative Effects of

D. Wraith, S. Anderton, C. Burkhart, 1998 .

Symptoms and risk factors for long COVID in non-hospitalized adults

G. Gkoutos, E. Sapey, T. Taverner, 2022, Nature Medicine.

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. 1986.

A. McMichael, J. Rothbard, D. Wraith, 2006, Journal of immunology.

Modulation of the immune response with T-cell epitopes: the ultimate goal for specific immunotherapy of autoimmune disease.

P. Travers, D. Wraith, P. Fairchild, 1994, Immunology.

IL-10 is essential for disease protection following intranasal peptide administration in the C57BL/6 model of EAE

D. Wraith, M. Day, E. O’Neill, 2006, Journal of Neuroimmunology.

Influenza peptide-induced self-lysis and down-regulation of cloned cytotoxic T cells.

R. Pemberton, D. Wraith, B. Askonas, 1990, Immunology.

T-helper 1 cells facilitate the entry of T-helper 17 cells to the central nervous system during experimental autoimmune encephalomyelitis

D. Wraith, S. Anderton, R. O’Connor, 2008 .

PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton

P. Verkade, D. Wraith, G. Britton, 2017, eLife.

A humanized HLA-DR4 mouse model for autoimmune myocarditis

D. Wraith, Anita C. Thomas, A. Newby, 2017, Journal of molecular and cellular cardiology.

E ﬀ ects of ATX-MS-1467 immunotherapy over 16 weeks in relapsing multiple sclerosis

B. Sharrack, D. Wraith, J. Chataway, 2022 .

Low avidity recognition of self-antigen by T cells permits escape from central tolerance.

D. Kioussis, D. Wraith, George Y. Liu, 1995, Immunity.

Adaptive T cell tuning in immune regulation and immunotherapy of autoimmune diseases.

D. Wraith, 2022, Immunology letters.

et al. A LAT-Based Signaling Complex in the Immunological Synapse as Determined with Live Cell Imaging Is Less Stable in T Cells with Regulatory Capability. Cells, 10(2),

F. Fallah-Arani, D. Wraith, S. Dovedi, 2021 .

Protein kinase C theta is required for efficient induction of IL-10-secreting T cells

D. Wraith, G. Britton, R. E. Mitchell, 2017, PloS one.

Modification of the FoxP3 Transcription Factor Principally Affects Inducible T Regulatory Cells in a Model of Experimental Autoimmune Encephalomyelitis

D. Wraith, J. Verhagen, S. Anderton, 2013, PloS one.

Modification of the FoxP 3 Transcription Factor Principally Affects Inducible T Regulatory Cells in a Model of Experimental Autoimmune Encephalomyelitis

D. Wraith, J. Verhagen, S. Anderton, 2013 .

Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease

A. Sharpe, D. Wraith, G. Anderson, 2009, Proceedings of the National Academy of Sciences.

Role of interleukin-10 in the induction and function of natural and antigen-induced regulatory T cells.

D. Wraith, 2003, Journal of autoimmunity.

Purified influenza virus nucleoprotein protects mice from lethal infection.

D. Wraith, B. Askonas, A. Vessey, 1987, The Journal of general virology.

Influenza virus-specific cytotoxic T-cell recognition: stimulation of nucleoprotein-specific clones with intact antigen.

D. Wraith, A. Vessey, 1986, Immunology.

Dk-restricted antiinfluenza cytotoxic t-cell clone loses one of its two alloreactivities

D. Wraith, 2004, Immunogenetics.

Induction of influenza A virus cross-reactive cytotoxic T cells by a nucleoprotein/haemagglutinin preparation.

D. Wraith, B. Askonas, 1985, The Journal of general virology.

Cytotoxic T Cells in Influenza: Their Role and Viral Specificities

D. Wraith, B. Askonas, P. Taylor, 1986 .

Membranes in Growth and Development

D. Wraith, 1984 .

Designing antigens for the prevention and treatment of autoimmune diseases

D. Wraith, 2018 .

Peptides containing a dominant T-cell epitope from red cell band 3 have in vivo immunomodulatory properties in NZB mice with autoimmune hemolytic anemia.

D. Wraith, R. Barker, Abdel-Rahman Youssef, 2003, Blood.

Identification of an indirectly presented epitope in a mouse model of skin allograft rejection.

D. Wraith, C. Burkhart, P. Lowrey, 1998, Transplantation.

Combinations of CD45 Isoforms Are Crucial for Immune Function and Disease

D. Wraith, S. Petrova, E. Tchilian, 2006, The Journal of Immunology.

Induction of antigen-specific unresponsiveness with synthetic peptides: specific immunotherapy for treatment of allergic and autoimmune conditions.

D. Wraith, 1995, International archives of allergy and immunology.

New inhibitory signaling by CTLA-4

D. Wraith, C. Wülfing, Helen M. Tunbridge, 2014, Nature Immunology.

Human mesenchymal stem cells abrogate experimental allergic encephalomyelitis after intraperitoneal injection, and with sparse CNS infiltration

D. Wraith, J. Uney, D. Gordon, 2008, Neuroscience Letters.

A role for major histocompatibility complex-binding peptides in the immunotherapy of autoimmune disease

D. Wraith, D. Smilek, 2004, Springer Seminars in Immunopathology.

The recognition of influenza A virus- infected cells by cytotoxic T lymphocytes.

D. Wraith, 1987, Immunology today.

Prolongation of murine vascularized heart allograft survival by recipient-specific anti-major histocompatibility complex class II antibody.

S. Metcalfe, D. Wraith, R. M. Smith, 1997, Transplantation.

Control of immune interferon release by cytotoxic T-cell clones specific for influenza.

D. Wraith, B. Askonas, P. Taylor, 1985, Immunology.

Avidity and the art of self non-self discrimination.

D. Wraith, 2006, Immunity.

A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis.

H. Mcdevitt, L. Steinman, D. Wraith, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Natural and induced regulatory T cells: targets for immunotherapy of autoimmune disease and allergy.

D. Wraith, K. Nicolson, 2006, Inflammation & allergy drug targets.

For Personal Use. Only Reproduce with Permission from the Lancet Publishing Group. Vaccination and Autoimmune Disease: What Is the Evidence?

M. Goldman, D. Wraith, P. Lambert, 2022 .

The adaptive immune system in diseases of the central nervous system.

D. Wraith, L. Nicholson, 2012, The Journal of clinical investigation.

Serological responses to SARS-CoV-2 following non-hospitalised infection: clinical and ethnodemographic features associated with the magnitude of the antibody response

M. Drayson, A. Cunningham, D. Wraith, 2021, BMJ Open Respiratory Research.

Serological responses to SARS-CoV-2 following non-hospitalised infection: clinical and ethnodemographic features associated with the magnitude of the antibody response

M. Drayson, A. Cunningham, D. Wraith, 2020, medRxiv.

SARS-CoV-2 seroprevalence and asymptomatic viral carriage in healthcare workers: a cross-sectional study

M. Drayson, A. Cunningham, D. Wraith, 2020, Thorax.

SARS-CoV-2 seroconversion in health care workers

M. Drayson, A. Cunningham, D. Wraith, 2020, medRxiv.

IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells 1

B. Stockinger, D. Wraith, A. Boonstra, 2004, The Journal of Immunology.

Fine specificity of myelin basic protein reactive T-cells: implications for T-cell receptor antagonism.

D. Wraith, S. Anderton, S. Manickasingham, 1997, Biochemical Society transactions.

Regulation of Adaptive Immunity; The Role of Interleukin-10

D. Wraith, J. Verhagen, G. Britton, 2013, Front. Immunol..

Regulatory CD4+ T cells and the control of autoimmune disease.

D. Wraith, K. Nicolson, N. Whitley, 2004, Current opinion in immunology.

Antigen and checkpoint receptor engagement recalibrates T cell receptor signal strength

D. Bending, D. Wraith, A. Flores-Langarica, 2021, Immunity.

University of Birmingham Antigen and checkpoint receptor recalibration of T cell receptor signal strength

D. Bending, D. Wraith, A. Flores-Langarica, 2021 .

Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: influence of MHC binding affinity.

D. Wraith, D C Wraith, B Metzler, 1993, International immunology.

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

H. Mcdevitt, M. Waldor, D. Mitchell, 1988, Cell.

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice.

Stefan Lüth, Harald Ittrich, Christian Waurisch, 2015, Journal of hepatology.

Chromatin Priming Renders T Cell Tolerance-Associated Genes Sensitive to Activation below the Signaling Threshold for Immune Response Genes

Sarah L Bevington, P. Cockerill, D. Wraith, 2020, Cell reports.

Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4+ T cells tolerized by peptide immunotherapy

J. Thomson, R. Meehan, D. Wraith, 2014, eLife.

Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy

Lawrence Steinman, H. Mcdevitt, D. Mitchell, 1989, Cell.

Immunotherapy With Apitopes Blocks the Immune Response to TSH Receptor in HLA-DR Transgenic Mice.

D. Wraith, K. Vrolix, L. Jansson, 2018, Endocrinology.

Myeloid‐derived suppressor cells mediate tolerance induction in autoimmune disease

D. Wraith, J. Verhagen, A. Wegner, 2017, Immunology.

T cell recognition as the target for immune intervention in autoimmune disease

Lawrence Steinman, H. Mcdevitt, L. Steinman, 1989, Cell.

Autoantigens in rheumatoid arthritis and the potential for antigen-specific tolerising immunotherapy.

D. Wraith, Ranjeny Thomas, V. Malmström, 2020, The Lancet. Rheumatology.

Cross-reactive antigen recognition by an encephalitogenic T cell receptor. Implications for T cell biology and autoimmunity.

D. Wraith, B. Bruun, P. Fairchild, 1992, Journal of immunology.

Antigenic strength controls the generation of antigen‐specific IL‐10‐secreting T regulatory cells

D. Wraith, L. Gabryšová, 2010, European journal of immunology.

Domain interactions of H–2 class I antigens alter cytotoxic T-cell recognition sites

P. Pala, R. Flavell, D. Wraith, 1984, Nature.

Fusion between human mesenchymal stem cells and rodent cerebellar Purkinje cells

D. Wraith, J. Uney, D. Gordon, 2011, Neuropathology and applied neurobiology.

Detection of antibodies to the SARS-CoV-2 spike glycoprotein in both serum and saliva enhances detection of infection

Mark J. Ponsford, M. Drayson, A. Cunningham, 2020, medRxiv.

The nature of cryptic epitopes within the self-antigen myelin basic protein.

D. Wraith, P. Fairchild, D C Wraith, 1996, International immunology.

Cutting Edge: Th1 Cells Facilitate the Entry of Th17 Cells to the Central Nervous System during Experimental Autoimmune Encephalomyelitis1

D. Wraith, M. Leech, S. Anderton, 2008, The Journal of Immunology.

Searching for MHC‐restricted anti‐viral antibodies: antibodies recognizing the nucleoprotein of influenza virus dominate the serological response of C57BL/6 mice to syngeneic influenza‐infected cells

D. Wraith, B. Barber, Wendy L. Tamminen, 1987, European journal of immunology.

Peptide-based therapeutic vaccines for allergic and autoimmune diseases

D. Wraith, M. Larché, Mark Larché, 2005, Nature Medicine.

Characterization of the dominant autoreactive T-cell epitope in spontaneous autoimmune haemolytic anaemia of the NZB mouse.

D. Wraith, R. Barker, C. Elson, 2002, Journal of autoimmunity.

Cross-reactivity and T-cell receptor antagonism of myelin basic protein-reactive T cells is modulated by the activation state of the antigen presenting cell.

D. Wraith, S. Anderton, S. Kissler, 2002, Journal of autoimmunity.

Selection and fine-tuning of the autoimmune T-cell repertoire

D. Wraith, S. Anderton, Stephen M. Anderton, 2002, Nature Reviews Immunology.

Negative Selection during the Peripheral Immune Response to Antigen

E. Ward, D. Wraith, C. Radu, 2001, The Journal of experimental medicine.

Qualitative and quantitative effects of CD28/B7-mediated costimulation on naive T cells in vitro.

D. Wraith, S. Anderton, C. Burkhart, 1998, Journal of immunology.

Cytotoxic T-cell recognition of influenza-infected target cells varies in different H-2k mouse strains

D. Wraith, B. Askonas, M. Stringfellow, 2004, Immunogenetics.

Loss of serological determinants does not affect recognition of H‐2Kk target cells by an influenza‐specific cytotoxic T cell clone

D. Wraith, B. Askonas, B. Holtkamp, 1983, European journal of immunology.

An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance induction.

D. Wraith, P. Fairchild, D C Wraith, 1993, International immunology.

IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation

D. Wraith, J. Verhagen, G. Britton, 2017, Scientific Reports.

Detection of autoreactive T cells in H-2u mice using peptide-MHC multimers.

E. Ward, D. Wraith, C. Radu, 2000, International immunology.

Vaccines to Treat Drug Addiction

R. Steinman, J. Banchereau, I. Cohen, 2004 .

Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10–secreting Th1 cells

D. Wraith, J. Verhagen, L. Gabryšová, 2009, The Journal of experimental medicine.

Influence of a dominant cryptic epitope on autoimmune T cell tolerance

N. Viner, D. Wraith, S. Anderton, 2002, Nature Immunology.

Activation thresholds determine susceptibility to peptide-induced tolerance in a heterogeneous myelin-reactive T cell repertoire

D. Wraith, S. Anderton, K. Ryan, 2004, Journal of Neuroimmunology.

Therapeutic potential of TCR antagonists is determined by their ability to modulate a diverse repertoire of autoreactive T cells

D. Wraith, S. Anderton, S. Kissler, 1999, European journal of immunology.

Mechanisms of central and peripehral T‐cell tolerance: lessons from experimental models of multiple sclerosis

D. Wraith, S. Anderton, C. Burkhart, 1999, Immunological reviews.

Fine specificity of the myelin-reactive T cell repertoire: implications for TCR antagonism in autoimmunity.

D. Wraith, S. Holland, S. Anderton, 1998, Journal of immunology.

of Antigen-specific immunotherapy with thyrotropin receptor peptides in Graves' hyperthyroidism

D. Wraith, G. Kahaly, C. Dayan, 2019 .

Control ofimmuneinterferon release bycytotoxic T-cell clones specific forinfluenza

D. Wraith, B. Askonas, P. Taylor, 1985 .

Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs.

W. Brück, C. Stadelmann, J. Herkel, 2008, The Journal of clinical investigation.

Glycogen synthase kinase-3 controls IL-10 expression in CD4+ effector T-cell subsets through epigenetic modification of the IL-10 promoter

D. Wraith, K. Malik, Elaine V. Hill, 2015, European journal of immunology.

Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease

Alistair L. J. Symonds, D. Kioussis, D. Wraith, 2008, The Journal of experimental medicine.

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

D. M. Smith, K. Okkenhaug, V. De Rosa, 2017, Immunity.

Regulatory T Cell Migratio n Is Dependent on Glucokinase-Mediated Glycolysis Graphical

K. Okkenhaug, D. Wraith, V. Rosa, 2017 .

CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire

Brian J. Stevenson, D. Wraith, J. Verhagen, 2012, Proceedings of the National Academy of Sciences.

MHC binding peptides as therapeutic agents.

D. Wraith, P. Fairchild, B. Metzler, 1993, Clinical and experimental rheumatology.

The Future of Immunotherapy: A 20-Year Perspective

D. Wraith, 2017, Front. Immunol..

Preclinical development and first-in-human study of ATX-MS-1467 for immunotherapy of MS

D. Wraith, N. Scolding, H. Streeter, 2015, Neurology: Neuroimmunology & Neuroinflammation.

Establishing the prevalence of common tissue‐specific autoantibodies following severe acute respiratory syndrome coronavirus 2 infection

M. Drayson, A. Cunningham, D. Wraith, 2021, Clinical and experimental immunology.

Development of a high‐sensitivity ELISA detecting IgG, IgA and IgM antibodies to the SARS‐CoV‐2 spike glycoprotein in serum and saliva

M. Drayson, A. Cunningham, M. O’Shea, 2021, Immunology.

Variant proteins stimulate more IgM+ GC B-cells revealing a mechanism of cross-reactive recognition by antibody memory

D. Wraith, J. Love, R. Titball, 2017, eLife.

IL-2 Overcomes the Unresponsiveness but Fails to Reverse the Regulatory Function of Antigen-Induced T Regulatory Cells1

D. Wraith, P. Anderson, S. Minaee, 2005, The Journal of Immunology.

Antigen-Induced T Regulatory Cells Fails to Reverse the Regulatory Function of IL-2 Overcomes the Unresponsiveness but

D. Wraith, S. Minaee, A. Sundstedt, 2004 .

SARS-CoV-2 infection is associated with anti-desmoglein 2 autoantibody detection

M. Drayson, G. Reynolds, A. Cunningham, 2022, medRxiv.

Human Mesenchymal Stem Cells Infiltrate the Spinal Cord, Reduce Demyelination, and Localize to White Matter Lesions in Experimental Autoimmune Encephalomyelitis

D. Wraith, J. Uney, D. Gordon, 2010, Journal of neuropathology and experimental neurology.

Blockade of LFA-1 augments in vitro differentiation of antigen-induced Foxp3+ Treg cells

D. Wraith, J. Verhagen, 2014, Journal of immunological methods.

IL-2 Overcomes the Unresponsiveness but Fails to Reverse the Regulatory Function of Antigen-Induced T Regulatory Cells

D. Wraith, P. Anderson, S. Minaee, 2005, The Journal of Immunology.

Anti‐cytokine vaccines and the immunotherapy of autoimmune diseases

D. Wraith, 2006, European journal of immunology.

Immunotherapy of autoimmune disease.

A. Cooke, D. Wraith, 1993, Current opinion in immunology.

The role of CTLA-4 in immune regulation

D. Wraith, J. Verhagen, C. A. Sabatos, 2008, Immunology letters.

Anti-class II MHC antibodies prevent and treat EAE without APC depletion.

D. Wraith, R. M. Smith, A. Morgan, 1994, Immunology.

T-cell receptor degeneracy: the dog that did not bark. Adaptation of the self-reactive T-cell response to limit autoimmune disease.

D. Wraith, L. Nicholson, 2004, Molecular immunology.

Immunotherapy of autoimmune disease with synthetic peptides.

D. Wraith, B. Metzler, 1994, Immunology today (Amsterdam. Regular ed.).

Differentiation and Function of Hematopoietic Cell Surfaces : Edited by V.T. Marchesi and R.C. Gallo Alan R. Liss; New York, 1982

D. Wraith, 1983 .

Serology confirms SARS-CoV-2 infection in PCR-negative children presenting with Paediatric Inflammatory Multi-System Syndrome

M. Drayson, A. Cunningham, D. Wraith, 2020, medRxiv.

Persistent antigenic stimulation alters the transcription program in T cells, resulting in antigen‐specific tolerance

Sabah Khalid, Alistair Symonds, Suling Li, 2006, European journal of immunology.

Establishing the prevalence of common, clinically relevant tissue-specific autoantibodies following SARS CoV-2 infection

M. Drayson, D. Wraith, S. Faustini, 2021 .

Considerations for patient and public involvement and engagement in health research

G. Gkoutos, E. Sapey, D. Wraith, 2023, Nature Medicine.

Splenic but not thymic autoreactive T cells from New Zealand Black mice respond to a dominant erythrocyte Band 3 peptide

Elson, D. Wraith, C. Elson, 1999, Immunology.

Polymorphic residues on the I-A beta chain modulate the stimulation of T cell clones specific for the N-terminal peptide of the autoantigen myelin basic protein.

J. Todd, H. Mcdevitt, D. Mitchell, 1989, Journal of immunology.

The use of MHC-binding peptides in the immunotherapy of autoimmune diseases: a commentary.

D. Wraith, 1991, Research in immunology.

SARS‐CoV‐2‐specific IgG1/IgG3 but not IgM in children with Pediatric Inflammatory Multi‐System Syndrome

M. Drayson, A. Cunningham, D. Wraith, 2020, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

K. Okkenhaug, V. De Rosa, G. Matarese, 2018, Immunity.

of Antigen-specific immunotherapy with thyrotropin receptor peptides in Graves' hyperthyroidism

D. Wraith, K. Boelaert, S. Razvi, 2019 .

Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice

R. O’Hehir, J. Lamb, W. Thomas, 1993, The Journal of experimental medicine.

Ability of T cells from patients with rheumatoid arthritis to respond to immunoglobulin G

Kirwan, Elson, D. Wraith, 1999, Immunology.

The Wiskott-Aldrich Syndrome Protein Regulates Nuclear Translocation of NFAT2 and NF-κB (RelA) Independently of Its Role in Filamentous Actin Polymerization and Actin Cytoskeletal Rearrangement1

Sambasiva P Rao, T. Manser, K. Vora, 1988, The Journal of Immunology.

Immunotherapy With Apitopes Blocks the Immune Response to TSH Receptor in HLA-DR Transgenic Mice.

D. Wraith, K. Vrolix, L. Jansson, 2018, Endocrinology.

Comment on “Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells”

D. Wraith, J. Verhagen, 2010, The Journal of Immunology.

Diversity and dynamics of the T‐cell response to MBP in DR2+ve individuals

J. Zajicek, D. Wraith, G. Mazza, 2002, Clinical and experimental immunology.

Phenotypic analysis of CTLA-4 and CD28 expression during transient peptide-induced T cell activation in vivo.

D. Wraith, B. Metzler, C. Burkhart, 1999, International immunology.

Inhibition of T‐cell responsiveness by nasal peptide administration: influence of the thymus and differential recovery of T‐cell‐dependent functions

D. Wraith, B. Metzler, Metzler, 1999, Immunology.

Differential responses of CD45+ve T‐cell subsets to MBP in multiple sclerosis

J. Zajicek, D. Wraith, G. Mazza, 2001, Clinical and experimental immunology.

Incidence of immune-mediated inflammatory diseases following COVID-19: a matched cohort study in UK primary care

D. Wraith, S. Haroon, K. Nirantharakumar, 2023, BMC Medicine.

Autoimmunity: Antigen-specific immunotherapy

D. Wraith, 2016, Nature.

CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire

Brian J. Stevenson, D. Wraith, J. Verhagen, 2012, Proceedings of the National Academy of Sciences.

Interferon-γ and IL-27 positively regulate type 1 regulatory T-cell development during adaptive tolerance

D. Bending, D. Wraith, L. Sheriff, 2024, bioRxiv.