C. Ward

发表

Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease.

Martijn H Breuning, Christopher J Ward, Dorien J M Peters, 2004, Human molecular genetics.

Phosphodiesterase 1A modulates cystogenesis in zebrafish.

V. Torres, P. Harris, C. Ward, 2014, Journal of the American Society of Nephrology : JASN.

Cyclic nucleotide signaling in polycystic kidney disease.

V. Torres, P. Harris, Xiaofang Wang, 2010, Kidney international.

The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

Vicente E. Torres, Dawn S. Milliner, Peter C. Harris, 2002, Nature Genetics.

Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity.

Vladimir G. Gainullin, V. Torres, P. Harris, 2012, The Journal of clinical investigation.

Activation of the AKT/mTOR pathway in autosomal recessive polycystic kidney disease (ARPKD).

B. Rudolph, C. Ward, C. Renken, 2009, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Modulation of Polycystic Kidney Disease Severity by Phosphodiesterase 1 and 3 Subfamilies.

C. Vorhees, J. V. van Deursen, M. Irazabal, 2016, Journal of the American Society of Nephrology : JASN.

Notch4 activation aggravates NF-κB-mediated inflammation in HIV-1-associated nephropathy

C. Ward, T. Fields, P. Singhal, 2019, Disease Models & Mechanisms.

Quantitative assessment of hepatic fibrosis in an animal model with magnetic resonance elastography

Armando Manduca, Richard L Ehman, Meng Yin, 2007, Magnetic resonance in medicine.

Inhibition of Cdc25A suppresses hepato-renal cystogenesis in rodent models of polycystic kidney and liver disease.

E. Ritman, N. LaRusso, N. Chandok, 2012, Gastroenterology.

Endothelial Outgrowth Cells Shift Macrophage Phenotype and Improve Kidney Viability in Swine Renal Artery Stenosis

L. Lerman, Hui Tang, R. Simari, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Aberrant Regulation of Notch3 Signaling Pathway in Polycystic Kidney Disease

B. Magenheimer, R. Maser, J. Calvet, 2018, Scientific Reports.

Generation and phenotypic characterization of Pde1a mutant mice

A. Behfar, J. V. van Deursen, M. Irazabal, 2017, PloS one.

Cyclic nucleotide signaling in polycystic kidney

V. Torres, P. Harris, C. Ward, 2010 .

Screening the 3' region of the polycystic kidney disease 1 (PKD1) gene reveals six novel mutations.

P. Harris, C. Ward, J. L. San Millán, 1996, American journal of human genetics.

Protein composition and movements of membrane swellings associated with primary cilia

Shao T. Lo, C. Ward, S. Nauli, 2015, Cellular and Molecular Life Sciences.

Coordinate expression of the autosomal dominant polycystic kidney disease proteins, polycystin-2 and polycystin-1, in normal and cystic tissue.

P. Harris, C. Ward, Y. Pei, 1999, The American journal of pathology.

Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia.

N. LaRusso, V. Torres, P. Harris, 2003, Human molecular genetics.

Identification and characterization of the tuberous sclerosis gene on chromosome 16

S. Thomas, S. Verhoef, B. Janssen, 1993, Cell.

Polycystic kidney disease. 1: Identification and analysis of the primary defect.

J. Hughes, P. Harris, C. Ward, 1995, Journal of the American Society of Nephrology : JASN.

Fibrocystin interacts with CAML, a protein involved in Ca2+ signaling.

K. Hujer, R. Bram, C. Ward, 2005, Biochemical and biophysical research communications.

Ciliary and centrosomal defects associated with mutation and depletion of the Meckel syndrome genes MKS1 and MKS3.

V. Torres, P. Harris, V. Gattone, 2009, Human molecular genetics.

A mouse model of autosomal recessive polycystic kidney disease with biliary duct and proximal tubule dilatation.

N. LaRusso, V. Torres, P. Harris, 2007, Kidney international.

A new epitope-tagged Pkhd1 allele sheds light on fibrocystin signaling.

C. Ward, W. Lea, 2017, Kidney international.

Case study: polycystic livers in a transgenic mouse line.

T. Diekwisch, C. Ward, Yoshihiro Ito, 2014, Comparative medicine.

Proteolytic Cleavage and Nuclear Translocation of Fibrocystin Is Regulated by Intracellular Ca2+ and Activation of Protein Kinase C*

N. LaRusso, P. Igarashi, P. Koulen, 2006, Journal of Biological Chemistry.

Defects in cholangiocyte fibrocystin expression and ciliary structure in the PCK rat.

N. LaRusso, V. Torres, P. Harris, 2003, Gastroenterology.

Analysis of the polycystin complex (PCC) in human urinary exosome–like vesicles (ELVs)

C. Ward, M. Hogan, W. Lea, 2020, Scientific Reports.

Human-Specific Abnormal Alternative Splicing of Wild-Type PKD1 Induces Premature Termination of Polycystin-1.

J. Calvet, C. Ward, D. Wallace, 2018, Journal of the American Society of Nephrology : JASN.

Insignificant effect of secretin in rodent models of polycystic kidney and liver disease.

N. LaRusso, V. Torres, P. Harris, 2012, American journal of physiology. Renal physiology.

Exosomes to the Rescue.

C. Ward, Jessica Rossol-Allison, 2015, Journal of the American Society of Nephrology : JASN.

Evidence of linkage disequilibrium in the Spanish polycystic kidney disease I population.

R. Stallings, F. Moreno, P. Harris, 1994, American journal of human genetics.

Pkd1 transgenic mice: adult model of polycystic kidney disease with extrarenal and renal phenotypes.

P. Harris, C. Ward, M. Couillard, 2010, Human molecular genetics.

A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD

B. Magenheimer, R. Maser, J. Calvet, 2018, Human molecular genetics.

MTBP inhibits the Erk1/2-Elk-1 signaling in hepatocellular carcinoma

T. Iwakuma, O. Tawfik, C. Ward, 2018, Oncotarget.

Functional characterization of PKDREJ, a male germ cell‐restricted polycystin

P. Harris, C. Ward, M. Jungnickel, 2006, Journal of cellular physiology.

Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia.

N. LaRusso, C. Ward, T. Masyuk, 2010, American journal of physiology. Gastrointestinal and liver physiology.

Homophilic and heterophilic polycystin 1 interactions regulate E-cadherin recruitment and junction assembly in MDCK cells

P. Harris, C. Ward, A. Ong, 2009, Journal of Cell Science.

Cytokine absorption during human kidney perfusion reduces delayed graft function–associated inflammatory gene signature

M. Clatworthy, C. Ward, M. Nicholson, 2020, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Distinguishing between Hepatic Inflammation and Fibrosis with MR Elastography.

A. Manduca, R. Ehman, M. Yin, 2017, Radiology.

THE POLYCYSTIC KIDNEY-DISEASE-1 GENE ENCODES A 14-KB TRANSCRIPT AND LIES WITHIN A DUPLICATED REGION ON CHROMOSOME-16

Siep Thomas, S. Verhoef, J. Hughes, 1994 .

Assessment of renal response with urinary exosomes in patients with AL amyloidosis: A proof of concept

A. Dispenzieri, M. Ramirez-Alvarado, C. Ward, 2017, American journal of hematology.

Germline PKHD1 mutations are protective against colorectal cancer

S. Thibodeau, G. Petersen, L. Boardman, 2011, Human Genetics.

A primary culture of mouse proximal tubular cells , established on collagen-coated membranes

Yanhong Wu, V. Torres, C. Ward, 2007 .

Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss

Elizabeth J. Atkinson, Douglas C. Wallace, Sumit Middha, 2011, Nature Genetics.

A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype.

J. Sharpe, J. Sloane-Stanley, L. Strmečki, 2000, Human molecular genetics.

Identification and characterization of the tuberous sclerosis gene on chromosome 16

S. Thomas, S. Verhoef, B. Janssen, 1993, Cell.

Deletion of the TSC2 and PKD1 genes associated with severe infantile polycystic kidney disease — a contiguous gene syndrome

J. Hughes, P. Harris, C. Ward, 1994, Nature Genetics.

Purification of exosome-like vesicles from urine.

C. Ward, M. Hogan, Christopher Y. Chen, 2013, Methods in enzymology.

Epitope-tagged Pkhd1 tracks the processing, secretion, and localization of fibrocystin.

J. V. van Deursen, Yanhong Wu, V. Torres, 2011, Journal of the American Society of Nephrology : JASN.

Characterization of PKD protein-positive exosome-like vesicles.

N. LaRusso, A. Leontovich, V. Torres, 2009, Journal of the American Society of Nephrology : JASN.

PKHDL1, a homolog of the autosomal recessive polycystic kidney disease gene, encodes a receptor with inducible T lymphocyte expression.

V. Torres, P. Harris, C. Ward, 2003, Human molecular genetics.

The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

J. Hughes, P. Harris, C. Ward, 1995, Nature Genetics.

The transmembrane protein meckelin (MKS3) is mutated in Meckel-Gruber syndrome and the wpk rat

Colin A. Johnson, R. Trembath, V. Torres, 2006, Nature Genetics.

Lowering of Pkd 1 expression is sufficient to cause polycystic kidney disease

M. DeRuiter, M. Breuning, D. Peters, 2004 .

Investigation of the transcriptional profile of human kidneys during machine perfusion reveals potential benefits of haemoadsorption

M. Clatworthy, C. Ward, M. Nicholson, 2019, bioRxiv.

Identification, Characterization, and Localization of a Novel Kidney Polycystin-1-Polycystin-2 Complex*

P. Harris, C. Ward, A. Ong, 2002, The Journal of Biological Chemistry.

Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein.

J. Hughes, P. Harris, C. Ward, 1999, Human molecular genetics.

Identification of gene mutations in autosomal dominant polycystic kidney disease through targeted resequencing.

B. Eckloff, V. Torres, P. Harris, 2012, Journal of the American Society of Nephrology : JASN.

Caspase-1 and the inflammasome promote polycystic kidney disease progression

M. Vitek, C. Ward, D. Wallace, 2022, Frontiers in Molecular Biosciences.

An investigation of the mechanisms underlying HIV-1-mediated inflammasome activation

C. Ward, 2017 .

Investigation of Primary Cilia in the Pathogenesis of Biliary Atresia

P. Harris, C. Ward, S. Rossetti, 2011, Journal of pediatric gastroenterology and nutrition.

A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells.

Angela Wandinger-Ness, Christopher J Ward, A. Wandinger-Ness, 2003, Molecular biology of the cell.

Differences in Immunoglobulin Light Chain Species Found in Urinary Exosomes in Light Chain Amyloidosis (AL)

M. Ramirez-Alvarado, C. Ward, M. Hogan, 2012, PloS one.

Detection of High Molecular Weight Light Chain Oligomers in Urinary Exosomes of Patients with AL Amyloidosis.

A. Dispenzieri, M. Ramirez-Alvarado, C. Ward, 2009 .

Relationship between Novel Isoforms, Functionally Important Domains, and Subcellular Distribution of CD164/Endolyn*

A. Zannettino, C. Ward, V. Buckle, 2001, The Journal of Biological Chemistry.

Strategy and rationale for urine collection protocols employed in the NEPTUNE study

J. Lieske, W. Ju, M. Bitzer, 2015, BMC Nephrology.

Subfractionation, characterization and in-depth proteomic analysis of glomerular membrane vesicles in human urine

Doug W. Mahoney, Roman M. Ženka, H. R. Bergen, 2013, Kidney international.

Haplotype analysis improves molecular diagnostics of autosomal recessive polycystic kidney disease.

V. Pankratz, E. Avner, J. Cunningham, 2005, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Insigniﬁcant effect of secretin in rodent models of polycystic kidney and liver disease

N. LaRusso, P. Harris, Xiaofang Wang, 2012 .

Polycystic Kidney Disease: Lessons Learned from Caenorhabditis elegans Mating Behavior

C. Ward, Madhulika Sharma, 2015, Current Biology.

Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects.

P. Harris, C. Ward, A. Perez-Atayde, 2001, Human molecular genetics.

Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.

P. Harris, K. Hopp, C. Ward, 2015, The Journal of clinical investigation.

biomicroscopymice by noninvasive ultrasound β Characterization of circulatory disorders in

Damien Garcia, P. Harris, C. Ward, 2007 .

Autosomal dominant polycystic kidney disease: molecular analysis.

J. Hughes, P. Harris, C. Ward, 1995, Human molecular genetics.

Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney.

P. Ratcliffe, H. Turley, P. Harris, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Vasopressin directly regulates cyst growth in polycystic kidney disease.

Yanhong Wu, V. Torres, P. Harris, 2008, Journal of the American Society of Nephrology : JASN.

Polycystin-1 expression in PKD1, early-onset PKD1, and TSC2/PKD1 cystic tissue.

P. Harris, C. Ward, S. Rossetti, 1999, Kidney international.

Surface Glycosylation Profiles of Urine Extracellular Vesicles

C. Ward, M. Hogan, M. Griffin, 2013, PloS one.

Aberrant Regulation of Notch3 Signaling Pathway in Polycystic Kidney Disease

B. Magenheimer, R. Maser, J. Calvet, 2018, Scientific Reports.

Identification of Biomarkers for PKD1 Using Urinary Exosomes.

Roman M. Ženka, J. Lieske, M. Irazabal, 2015, Journal of the American Society of Nephrology : JASN.

A large duplicated area in the polycystic kidney disease 1 (PKD1) region of chromosome 16 is prone to rearrangement.

R. Stallings, P. Ratcliffe, P. Harris, 1994, Genomics.

Genetic analysis of Cuban autosomal dominant polycystic kidney disease kindreds using RFLPs and microsatellite polymorphisms linked to the PKD1 locus

F. Moreno, P. Harris, C. Ward, 1994, Human Genetics.

Analysis of the polycystins in aortic vascular smooth muscle cells.

S. Somlo, V. Torres, P. Harris, 2003, Journal of the American Society of Nephrology : JASN.

1 Lowering of Pkd 1 expression is sufficient to cause polycystic kidney disease

M. DeRuiter, M. Breuning, D. Peters, 2004 .

Polycystin-1 Interacting Protein-1 (CU062) Interacts with the Ectodomain of Polycystin-1 (PC1).

J. Calvet, C. Ward, D. Wallace, 2023, Cells.

Identification of gene mutations in autosomal dominant polycystic kidney disease through targeted resequencing.

B. Eckloff, V. Torres, P. Harris, 2012, Journal of the American Society of Nephrology : JASN.