D. Middleton

发表

Association of functional haem oxygenase-1 gene promoter polymorphism with polycystic kidney disease and IgA nephropathy.

A. Courtney, P. McNamee, S. Heggarty, 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Allele resolution of HLA-A using oligonucleotide probes in a two-stage typing strategy.

D. Middleton, A. Maxwell, F. Williams, 1999, Tissue antigens.

16th IHIW: Extending the number of resources and bioinformatics analysis for the investigation of HLA rare alleles

Andrew R. Jones, Jill A. Hollenbach, Steven J. Mack, 2012, International journal of immunogenetics.

Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools

Andrew R. Jones, D. Middleton, A. Alfirevic, 2019, Nucleic Acids Res..

Common and well-documented HLA alleles: 2012 update to the CWD catalogue.

W. Klitz, A. Sanchez‐Mazas, E. Reed, 2013, Tissue antigens.

The extensive polymorphism of KIR genes

Derek Middleton, D. Middleton, F. Gonzelez, 2010, Immunology.

A community standard for immunogenomic data reporting and analysis: proposal for a STrengthening the REporting of Immunogenomic Studies statement.

S G E Marsh, G Thomson, M Maiers, 2011, Tissue antigens.

Preliminary analysis of a KIR haplotype estimation algorithm: a simulation study.

A. Cambon-Thomsen, P. Gourraud, D. Middleton, 2007, Tissue antigens.

The role of human leukocyte antigen genes in the formation of abdominal aortic aneurysms.

D. Middleton, C. Soong, M. O'donnell, 2007, Journal of vascular surgery.

Parvovirus B19 in kidney transplant patients.

D. Middleton, B. Rima, P. Coyle, 2000, Transplantation.

No Impact of KIR‐Ligand Mismatch on Allograft Outcome in HLA‐Compatible Kidney Transplantation

D. Middleton, G. Opelz, B. Döhler, 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Survival of DNA HLA-DR typed and matched cadaver kidney transplants

J. Chapman, D. Middleton, E. Albert, 1991, The Lancet.

Study of age-association with cytokine gene polymorphisms in an aged Irish population

D. Middleton, Y. Barnett, A. Meenagh, 2003, Mechanisms of Ageing and Development.

Human leucocyte antigen–adverse drug reaction associations: from a perspective of ethnicity

D. Middleton, A. Alfirevic, R. Dickson, 2017, International journal of immunogenetics.

The Influence of Cytomegalovirus on Expression of HLA‐G and its Ligand KIR2DL4 by Human Peripheral Blood Leucocyte Subsets

D. Middleton, L. Bonnett, S. Christmas, 2017, Scandinavian journal of immunology.

Mismatched Human Leukocyte Antigen Alleles Protect Against Heterosexual HIV Transmission

R. Brettle, D. Middleton, P. Yap, 2001, Journal of acquired immune deficiency syndromes.

Association of microsatellite markers on chromosomes 6q27 region and 10p15 region with end-stage renal disease in a UK renal transplant population

A. McKnight, A. Courtney, D. Middleton, 2009, Journal of Human Genetics.

The Role of PGC-1a Overexperssion in Skeletal Muscle Exosome Biogenesis and Secretion

D. Middleton, 2020 .

No association of KIR3DL1 or KIR3DS1 or their alleles with ankylosing spondylitis.

D. Middleton, Bryan Paul Wordsworth, J. McCappin, 2010, Tissue antigens.

Linkage disequilibrium organization of the human KIR superlocus: implications for KIR data analyses

A. Cambon-Thomsen, P. Gourraud, D. Middleton, 2010, Immunogenetics.

Mutation screening in exons 3 and 4 of alpha-synuclein in sporadic Parkinson's and sporadic and familial dementia with Lewy bodies cases.

E. Jaros, D. Middleton, R. Perry, 1998, Neuroreport.

Multiple copies of KIR 3DL/S1 and KIR 2DL4 genes identified in a number of individuals.

D. Middleton, A. Meenagh, I. Halfpenny, 2003, Human immunology.

Interaction between immunoglobulin allotypes and NK receptor genes in diabetes post-hepatitis C virus infection.

D. Middleton, C. Larsen, E. Yunis, 2011, Immunobiology.

HLA class II frequencies in celiac disease patients in the west of Ireland.

D. Middleton, F. Stevens, D. Savage, 1992, Human immunology.

HLA-DR and DQ DNA genotyping in multiple sclerosis patients in Northern Ireland.

D. Middleton, D. Savage, S. Hawkins, 1991, Human immunology.

Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST study. Reciprocal effects on IL-6, soluble IL-6 receptor and for IL-10 in serum and monocyte supernatants

D. Middleton, O. Ross, S. Mcnerlan, 2003, Mechanisms of Ageing and Development.

A snapshot of human leukocyte antigen (HLA) diversity using data from the Allele Frequency Net Database.

Andrew R. Jones, D. Middleton, F. Gonzalez-Galarza, 2020, Human immunology.

Allele Frequency Net Database.

Andrew R. Jones, D. Middleton, F. Gonzalez-Galarza, 2018, Methods in molecular biology.

HLA class II typing of whole genome amplified mouth swab DNA.

P. Bingley, J. Todd, D. Middleton, 2000, Tissue antigens.

Increased killer immunoglobulin‐like receptor expression and functional defects in natural killer cells in lung cancer

D. Middleton, E. Marshall, S. Christmas, 2011, Immunology.

Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002.

M. Carrington, C. Witt, P. Parham, 2003, Immunogenetics.

Study of KIR genes in tuberculosis patients.

D. Middleton, A. Meenagh, M. Sarmiento, 2006, Tissue antigens.

A special report: histocompatibility testing guidelines for hematopoietic stem cell transplantation using volunteer donors. Quality Assurance and Donor Registries Working Groups of the World Marrow Donor Association.

F. Christiansen, D. Middleton, C. Hurley, 1999, Human immunology.

A special report: histocompatibility testing guidelines for hematopoietic stem cell transplantation using volunteer donors.

F. Christiansen, D. Middleton, C. Hurley, 1999, Tissue antigens.

Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with solid tumors.

D. Middleton, J. Field, D. Porter, 2010, Human immunology.

Functional Polymorphism of the KIR3DL1/S1 Receptor on Human NK Cells1

P. Parham, D. Middleton, C. Gardiner, 2007, The Journal of Immunology.

KIR 3 DL 1 / S 1 Receptor on Human NK Cells Functional Polymorphism of the Gardiner Cunningham

P. Parham, D. Middleton, C. Gardiner, 2006 .

Investigation of killer cell immunoglobulin-like receptor gene diversity: IV. KIR3DL1/S1.

D. Middleton, Y. Barnett, I. Halfpenny, 2004, Human immunology.

Investigation of killer cell immunoglobulinlike receptor gene diversity: I. KIR2DL4.

D. Middleton, A. Meenagh, F. Williams, 2004, Human immunology.

Determination of HLA‐A, ‐C, ‐B, ‐DRB1 allele and haplotype frequency in Japanese population based on family study

D. Middleton, H. Saji, T. Futagami, 2015, Tissue antigens.

Identification of three novel alleles of HLA-DRB1 and HLA-A in the Brazilian population.

D. Middleton, M. Torres, M. Moraes, 2007, Tissue antigens.

Identification of two novel alleles HLA-B*3569 and -B*4450 and confirmation of HLA-A*2631 in the Brazilian population.

D. Middleton, M. Moraes, A. C. Goncales, 2007, Tissue antigens.

A HLA-Cw*03 allele, Cw*0322Q with limited or no expression.

D. Middleton, A. Meenagh, S. Marsh, 2006, Tissue antigens.

Characterisation of a novel HLA-A pseudogene, HLA-BEL, with significant sequence identity with a gorilla MHC class I gene.

D. Middleton, F. Williams, M. Curran, 1999, Tissue antigens.

The search for HLA-matched donors: a summary of HLA-A*, -B*, -DRB1/3/4/5* alleles and their association with serologically defined HLA-A, -B, -DR antigens.

D. Middleton, C. Hurley, M. Lau, 1997, Tissue antigens.

16th IHIW: Immunogenetics of Aging

C. Franceschi, G. Pawelec, C. Caruso, 2013, International journal of immunogenetics.

Investigation of killer cell immunoglobulin-like receptor (KIR) gene diversity: KIR2DL2, KIR2DL5 and KIR2DS5.

D. Middleton, A. Meenagh, A. Gonzalez, 2008, Tissue antigens.

KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations.

D. Middleton, F. Williams, N. Paladino, 2007, Tissue antigens.

Studies on the expression of the deleted KIR2DS4*003 gene product and distribution of KIR2DS4 deleted and nondeleted versions in different populations.

D. Middleton, Asensio A. Gonzalez, Paula M. Gilmore, 2007, Human immunology.

A new HLA-DRB1*11 allele (DRB1*1109) differing at codons 32, 34 and 37.

D. Hughes, D. Middleton, F. Williams, 1994, Tissue antigens.

An HLA-DRB1*04 first domain sequence (DRB1*0416) which differs from HLA-DRB1*0401 at codon 59.

D. Hughes, D. Middleton, C. Graham, 1994, Tissue antigens.

A new DRB1 allele DRB1*1107--a combination of DRB1*11 and DRB1*03.

D. Hughes, D. Middleton, C. Graham, 1993, Tissue antigens.

2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells

J. Trowsdale, D. Middleton, J. Traherne, 2015, Genes and Immunity.

Killer cell immunoglobulin-like receptor allele discrimination by high-resolution melting.

D. Middleton, A. Meenagh, Asensio A. Gonzalez, 2009, Human immunology.

Investigation of killer cell immunoglobulin-like receptor gene diversity, KIR2DL1 and KIR2DS1.

D. Middleton, A. Meenagh, A. Gonzalez, 2008, Tissue antigens.

Investigation of killer cell immunoglobulin-like receptor gene diversity: II. KIR2DS4.

D. Middleton, A. Meenagh, F. Williams, 2004, Human immunology.

High incidence of the Cys 282 Tyr mutation in the HFE gene in the Irish population--implications for haemochromatosis.

D. Middleton, M. Callender, N. Mcdougall, 1998, Tissue antigens.

Peptide antagonism as a mechanism for NK cell activation

T. Elliott, M. Purbhoo, F. Claas, 2010, Proceedings of the National Academy of Sciences.

Signatures of natural selection and coevolution between killer cell immunoglobulin-like receptors (KIR) and HLA class I genes

D. Middleton, A. Meenagh, C. Gardiner, 2010, Genes and Immunity.

Functional promoter region polymorphism of the proinflammatory chemokine IL-8 gene associates with Parkinson's disease in the Irish.

D. Middleton, T. Lynch, O. Ross, 2004, Human immunology.

Aberrant splicing of intron 1 creates a novel null HLA-B*1501 allele.

A. Little, D. Middleton, F. Williams, 1999, Tissue antigens.

Techniques used to define human MHC antigens: restriction fragment length polymorphisms.

D. Middleton, 1991, Immunology letters.

Five new TaqI DRB1 polymorphisms.

D. Middleton, D. Savage, C. Cullen, 1991, Human immunology.

Identification of HLA-DRw52 associated antigens using HLA class II allogenotyping.

D. Middleton, J. Bidwell, D. Savage, 1988, Tissue antigens.

Association of HLA-DRBr with HLA-DQw3.

D. Middleton, J. Bidwell, D. Savage, 1988, Tissue antigens.

Discrepancies in serological tissue typing revealed by DNA techniques

D. Middleton, D. Savage, C. Cullen, 1988, Transplant international : official journal of the European Society for Organ Transplantation.

Association of Functional Heme Oxygenase‐1 Gene Promoter Polymorphism with Renal Transplantation Outcomes

A. Courtney, P. McNamee, S. Heggarty, 2007, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Mismatched human leukocyte antigen alleles protect against heterosexual HIV transmission.

R. Brettle, D. Middleton, P. Yap, 2001 .

Title Linkage disequilibrium organization of the human KIR superlocus : implications for KIR data analyses Permalink

A. Cambon-Thomsen, P. Gourraud, D. Middleton, 2010 .

A DNA‐RFLP TYPING SYSTEM THAT POSITIVELY IDENTIFIES SEROLOGICALLY WELL‐DEFINED AND ILL‐DEFINED HLA‐DR AND DQ ALLELES, INCLUDING DRw10

D. Middleton, J. Bidwell, D. Savage, 1988, Transplantation.

HLA antigen frequencies and Wegener's granulomatosis.

D. Middleton, A. Maxwell, D. Savage, 1991, Clinical otolaryngology and allied sciences.

Antigen Report: HLA-Bw60

D. Middleton, S. Goldmann, L. Kennedy, 1984 .

Antigen Report: HLA-Bw61

D. Middleton, S. Goldmann, L. Kennedy, 1984 .

HLA class I DNA typing of 215 "HLA-A, -B, -DR zero mismatched" kidney transplants.

D. Middleton, F. Williams, G. Opelz, 1997, Tissue antigens.

A novel HLA-B allele, HLA-B*1803.

D. Middleton, F. Williams, M. Curran, 1996, Tissue antigens.

Identification of a new HLA-B*55 allele, HLA-B*5503.

R. Vaughan, D. Middleton, F. Williams, 1996, Tissue antigens.

A new HLA-B51 allele, B*5107 in RCE55 detected and characterized by PCR-SSOP, cloning and nucleotide sequence determination.

D. Middleton, F. Williams, B. Rima, 1996, Tissue antigens.

LONG‐RANGE PCR AMPLIFICATION AS AN ALTERNATIVE STRATEGY FOR CHARACTERIZING NOVEL HLA‐B ALLELES

M. Bunce, D. Middleton, F. Williams, 1996, European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics.

HLA-A *2607: sequence of a novel A*26 subtype predicted by DNA typing which shares the MA2.1 epitope with A*02, B*57 and B*58.

J. Bodmer, P. Parham, D. Middleton, 1996, Tissue antigens.

Live donor renal transplantation — the experience of the belfast renal unit

D. Middleton, M. Mcgeown, J. Kennedy, 1989, Irish journal of medical science.

The outcome of pediatric cadaveric renal transplantation in the UK and Eire

Rachel J. Johnson, S. Fuggle, D. Middleton, 2002, Pediatric transplantation.

Evaluation of Five Interleukin Genes for Association with End-Stage Renal Disease in White Europeans

M. Simmonds, S. Gough, A. McKnight, 2010, American Journal of Nephrology.

An RFLP Study of HLA-D Gene Polymorphism in Multiple Sclerosis

W. Mcdonald, R. Lechler, R. Fauchet, 1989 .

Molecular analysis of HLA class I alleles in the Mexican Seri Indians: implications for their origin.

D. Middleton, F. Williams, C. Gorodezky, 1999, Tissue antigens.

Paraoxonase polymorphisms are not associated with cardiovascular risk in renal transplant recipients.

P. McNamee, D. Middleton, A. Maxwell, 1999, Kidney international.

KIR receptors and HLA-C in the maintenance of pregnancy.

D. Middleton, F. Williams, N. Paladino, 2007, Tissue antigens.

Killer Immunoglobulin-like Receptors (KIR) haplogroups A and B track with Natural Killer Cells and Cytokine Profile in Aged Subjects: Observations from Octo/Nonagenarians in the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST)

D. Middleton, O. Ross, S. Mcnerlan, 2013, Immunity & Ageing.

Duplication, mutation and recombination of the human orphan gene KIR2DS3 contribute to the diversity of KIR haplotypes

D. Middleton, A. Meenagh, C. Vilches, 2008, Genes and Immunity.

Investigation of killer cell immunoglobulin-like receptor gene diversity V. KIR3DL2.

D. Middleton, A. Meenagh, I. Halfpenny, 2004, Tissue antigens.

Investigation of KIR diversity in immunosenecence and longevity within the Irish population

D. Middleton, O. Ross, I. Rea, 2004, Experimental Gerontology.

Investigation of killer cell immunoglobulin-like receptor gene diversity III. KIR2DL3.

D. Middleton, A. Meenagh, F. Williams, 2004, Tissue antigens.

A multi-laboratory characterization of the KIR genotypes of 10th International Histocompatibility Workshop cell lines.

R. Vaughan, D. Middleton, P. Norman, 2003, Human immunology.

HLA antigens and multiple sclerosis in northern Ireland

D. Middleton, S. Hawkins, J. Morrow, 1990, Irish journal of medical science.

Antigen Society #1 Report (A1, Aw36, A3, A11, A9, A23, A24)

D. Middleton, R. Good, J. Marwick, 1989 .

14th International HLA and Immunogenetics Workshop: report on KIR receptors and their applications.

F. Christiansen, D. Middleton, 2007, Tissue antigens.

An interluekin 1B allele, which correlates with a high secretor phenotype, is associated with diabetic nephropathy.

D. Middleton, A. Maxwell, C. Patterson, 1998, Cytokine.

TAP1 and TAP2 polymorphism in multiple sclerosis patients.

D. Middleton, D. Savage, S. Hawkins, 1994, Human immunology.

Distinct diversity of KIR genes in three southern Indian populations: comparison with world populations revealed a link between KIR gene content and pre-historic human migrations

R. Pitchappan, E. Reed, D. Middleton, 2008, Immunogenetics.

No association of KIR genes with Behcet's disease.

P. Gourraud, H. Tozkır, D. Middleton, 2007, Tissue antigens.

Structural relationship between the two IgY of the duck, Anas platyrhynchos: molecular genetic evidence.

G. Warr, D. Middleton, M. Wilson, 1992, Journal of immunology.

Analysis of HLA-DR matching in DNA-typed cadaver kidney transplants.

J. Chapman, D. Middleton, D. Savage, 1993, Transplantation.

Application of an HLA-B PCR-SSOP typing method to a bone marrow donor registry

D. Middleton, F. Williams, H. Mawhinney, 1997, Bone Marrow Transplantation.

Increased numbers but functional defects of CD56+CD3+ cells in lung cancer.

D. Middleton, E. Marshall, S. Christmas, 2012, International immunology.

Increased numbers but functional defects of CD 56 1 CD 3 1 cells in lung cancer

D. Middleton, E. Marshall, S. Christmas, 2012 .

16th IHIW: Population Global Distribution of Killer Immunoglobulin‐like Receptor (KIR) and Ligands

D. Middleton, O. Rickards, J. Hollenbach, 2012, International journal of immunogenetics.

Current and emerging technology for HLA typing

D. Middleton, 2002, International journal of hematology.

Histocompatibility testing: a practical approach

D. Middleton, P. Dyer, 1993 .

Lack of association between KIR and HLA-C type and susceptibility to idiopathic bronchiectasis.

J. Lordan, P. Corris, D. Middleton, 2014, Respiratory medicine.

Human NK cell education by inhibitory receptors for MHC class I.

D. Middleton, C. Stewart, É. Vivier, 2006, Immunity.

Comparison of serological and DNA HLA‐DR typing results for transplantation in Western Europe, Eastern Europe, North America and South America

J. Chapman, D. Middleton, G. Opelz, 1994, Transplant international : official journal of the European Society for Organ Transplantation.

Identification of MHC--molecular biology.

D. Middleton, 1994, Transplant immunology.

HLA-A, -B, -C, -DRB1, and -DQB1 Allele Lineages and Haplotype Frequencies among Saudis

D. Middleton, F. Gonzalez-Galarza, M. Mubasher, 2014 .

HLA class I polymorphism in the Cuban population.

D. Middleton, A. Ferrer, M. Nazábal, 2007, Human immunology.

Frequency of HLA-B alleles in a Caucasoid population determined by a two-stage PCR-SSOP typing strategy.

M. Hamill, D. Middleton, A. Meenagh, 2000, Human immunology.

Analysis of KIR gene frequencies in HLA class I characterised bladder, colorectal and laryngeal tumours.

D. Middleton, F. Garrido, F. Williams, 2007, Tissue antigens.

H.L.A. antigens in proliferative diabetic retinopathy

D. Hadden, D. Middleton, D. Archer, 1981, International Ophthalmology.

Genetic damage and ageing T cells

D. Middleton, Y. Barnett, O. Ross, 2002 .

Mitochondrial DNA polymorphism: its role in longevity of the Irish population

Derek Middleton, Martin D Curran, D. Middleton, 2001, Experimental Gerontology.

Immunogenetics as a tool in anthropological studies

E. Thorsby, A. Sanchez‐Mazas, D. Middleton, 2011, Immunology.

Risk for Alzheimer's disease in older late-onset cases is associated with HLA-DRB1*03

P. Ince, E. Jaros, D. Middleton, 1999, Neuroscience Letters.

HLA‐DR antigens associated with major genetic risk for late‐onset Alzheimer's disease

I. McKeith, C. Morris, D. Middleton, 1997, Neuroreport.

Effect of a dCTP:dTTP pool imbalance on DNA replication fidelity in friend murine erythroleukemia cells

D. Middleton, Y. Barnett, Y. Barnett, 2000, Environmental and molecular mutagenesis.

Mitochondrial J haplogroup is associated with lower blood pressure and anti-oxidant status: findings in octo/nonagenarians from the BELFAST Study

D. Middleton, G. Archbold, O. Ross, 2012, AGE.

HLA antigen frequency in erythema multiforme and in recurrent herpes simplex.

D. Middleton, T. Hutchison, J. Lynd, 2008, Tissue antigens.

HLA antigen frequency in granuloma annulare

D. Middleton, G. Allen, 1984, The British journal of dermatology.

Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations

Andrew R. Jones, Faviel F. Gonzalez-Galarza, Stephen Christmas, 2010, Nucleic Acids Res..

New allele frequency database: www.allelefrequencies.net

Derek Middleton, D. Middleton, L. Menchaca, 2003 .

New allele frequency database: http://www.allelefrequencies.net.

D Middleton, D. Middleton, L Menchaca, 2003, Tissue antigens.

CD56+ T cells are increased in kidney transplant patients following cytomegalovirus infection

D. Middleton, I. Hart, A. Hammad, 2015, Transplant infectious disease : an official journal of the Transplantation Society.

Critical Evaluation of the Amino Acid Triplet-Epitope Matching Concept in Cadaver Kidney Transplantation.

D. Middleton, 2004 .

DNA HLA-DR typing results of 4000 kidney transplants.

J. Chapman, D. Middleton, D. Savage, 1993, Transplantation.

HLA TYPING FROM SEROLOGY TO SEQUENCING ERA

D. Middleton, 2005 .

Frequency of HLA-DPB1 alleles, including a novel DPB1 sequence, in the Northern Ireland population.

D. Middleton, D. Savage, C. Darke, 1992, Human immunology.

The IL12B 3′ untranslated region DNA polymorphism is not associated with early-onset type 1 diabetes

D. Middleton, A. Maxwell, D. Savage, 2002, Genes and Immunity.

Strategies to work with HLA data in human populations for histocompatibility, clinical transplantation, epidemiology and population genetics: HLA-NET methodological recommendations

B. Lie, S. Buus, A. Sanchez‐Mazas, 2012, International journal of immunogenetics.

The silent KIR3DP1 gene (CD158c) is transcribed and might encode a secreted receptor in a minority of humans, in whom the KIR3DP1, KIR2DL4 and KIR3DL1/KIR3DS1 genes are duplicated

D. Middleton, I. Halfpenny, C. Vilches, 2005, European journal of immunology.

A study of the HLA-DR region in clinical subgroups of multiple sclerosis and its influence on prognosis

D. Middleton, G. McDonnell, C. Graham, 1999, Journal of the Neurological Sciences.

Distribution of killer cell immunoglobulinlike receptors in the Macedonian population.

M. Spiroski, D. Middleton, A. Petlichkovski, 2010, Human immunology.

Receptor systems controlling natural killer cell function are genetically stratified in Europe

D Middleton, D. Middleton, A. Meenagh, 2010, Genes and Immunity.

No association in frequency of KIR receptors in patients with rheumatoid arthritis from Northern Ireland.

D. Middleton, A. Meenagh, G. Wright, 2007, Tissue antigens.

Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis.

A. Bowcock, D. Middleton, A. Meenagh, 2005, Human immunology.

Reassessing the Impact of Donor HLA‐C Genotype on Long‐Term Liver Transplant Survival

D. Middleton, A. Meenagh, G. Opelz, 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

A database for curating the associations between killer cell immunoglobulin-like receptors and diseases in worldwide populations

Andrew R. Jones, Faviel F. Gonzalez-Galarza, Derek Middleton, 2013, Database J. Biol. Databases Curation.

Diversity of KIR Genes, Alleles and Haplotypes

P. Gourraud, D. Middleton, A. Meenagh, 2010 .

Different Evolution of Inhibitory and Activating Killer Immunoglobulin Receptors (KIR) in Worldwide Human Populations

D. Middleton, A. Arnaiz-Villena, A. Meenagh, 2008 .

Killer immunoglobulin receptor gene and allele frequencies in Caucasoid, Oriental and Black populations from different continents.

D. Middleton, A. Arnaiz-Villena, A. Meenagh, 2007, Tissue antigens.

KIR haplotype content at the allele level in 77 Northern Irish families

P. Gourraud, D. Middleton, A. Meenagh, 2007, Immunogenetics.

Development of a PCR-SSOP approach capable of defining the natural killer cell inhibitory receptor (KIR) gene sequence repertoires.

D Middleton, D. Middleton, S. Logue, 2000, Tissue antigens.

FREQUENCY OF HLA‐DPB1 ALLELES IN MULTIPLE SCLEROSIS PATIENTS FROM NORTHERN IRELAND

D. Middleton, D. Savage, S. Hawkins, 1992, European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics.

An allelic cluster of DQ alpha restriction fragments is associated with multiple sclerosis: evidence that a second haplotype may influence disease susceptibility.

W. Mcdonald, R. Lechler, D. Francis, 1989, Human immunology.

The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans

Loren Gragert, Martin Maiers, Richard E. Green, 2011, Science.

Mechanisms of copy number variation and hybrid gene formation in the KIR immune gene complex

M. Carrington, J. Trowsdale, D. Middleton, 2009, Human molecular genetics.

Evaluating differences in linkage disequilibrium between populations

H. Stefánsson, D. Gudbjartsson, J. Gulcher, 2010, Annals of human genetics.

Impact of sensitivity of human leucocyte antigen antibody detection by Luminex technology on graft loss at 1 year

P. Szatmary, D. Middleton, James Jones, 2013, Clinical kidney journal.

THE INFLUENCE OF HLA‐A, B, AND DR MATCHING ON GRAFT SURVIVAL INPARIMARY CADAVERIC RENAL TRANSPLANTATION IN BELFAST

D. Middleton, M. Mcgeown, E. L. Gillespie, 1985, Transplantation.

A new DQw1 associated antigen: HLA-DR'Br'.

D. Middleton, P. Klouda, G. Laundy, 2008, Tissue antigens.

Imbalance of Genes Encoding Natural Killer Immunoglobulin-like Receptors and Human Leukocyte Antigen in Patients With Biliary Cancer.

D. Middleton, B. Isaksson, F. Gonzalez-Galarza, 2019, Gastroenterology.

High resolution allele genotyping and haplotype frequencies for NGS based HLA 11 loci of 5266 Hong Kong Chinese bone marrow donors.

D. Middleton, P. Ip, Wanling Yang, 2020, Human immunology.

HLA-DQB1, -DQA1, -DPB1, and -DPA1 genotyping and haplotype frequencies for a Hong Kong Chinese population of 1064 individuals.

D. Middleton, Wanling Yang, J. Kwok, 2019, Human immunology.

Common and well‐documented HLA alleles over all of Europe and within European sub‐regions: A catalogue from the European Federation for Immunogenetics

A. Sanchez‐Mazas, D. Middleton, S. Buhler, 2017, HLA.

Simulation of non-inherited maternal antigens acceptable HLA mismatches to increase the chance of matched cord blood units: Hong Kong's experience.

D. Middleton, P. Ip, M. Guo, 2018, Human immunology.

Temporal, quantitative, and functional characteristics of single-KIR-positive alloreactive natural killer cell recovery account for impaired graft-versus-leukemia activity after haploidentical hematopoietic stem cell transplantation.

M. Sormani, D. Middleton, M. Roncarolo, 2008, Blood.

A new allele frequency database

Derek Middleton, D. Middleton, Elizabeth M. Menchaca, 2002 .

Revisit of Optimal Donor Number Estimation in the Hong Kong Bone Marrow Donor Registry

D. Middleton, P. Ip, Wanling Yang, 2021, Frontiers in Immunology.

Estimation of optimal donor number in Bone Marrow Donor Registry: Hong Kong's experience.

D. Middleton, P. Ip, M. Guo, 2017, Human immunology.

Killer immunoglobulin-like receptors (KIR2DL2 and/or KIR2DS2) in presence of their ligand (HLA-C1 group) protect against chronic myeloid leukaemia.

P. Gourraud, D. Middleton, A. Meenagh, 2009, Tissue antigens.

A bioinformatics tool for epitope-based vaccine design that accounts for human ethnic diversity: application to emerging infectious diseases.

Andrew R Jones, Bostjan Kobe, Derek Middleton, 2015, Vaccine.

Histocompatibility testing guidelines for hematopoietic stem cell transplantation using volunteer donors: report from The World Marrow Donor Association

F. Christiansen, D. Middleton, J. Hegland, 1999, Bone Marrow Transplantation.

One thousand renal transplants at Belfast City Hospital: post-graft neoplasia 1968-1999, comparing azathioprine only with cyclosporin-based regimes in a single centre.

D. Middleton, M. Mcgeown, J. Douglas, 2000, Clinical transplants.

Natural killer cells and their receptors.

D. Middleton, M. Curran, L. Maxwell, 2002, Transplant immunology.

Hemophagocytic lymphohistiocytosis in adults

D. Middleton, B. Firwana, M. Bimali, 2020, Proceedings.

Genetic diversity in the non-structural gene of parvovirus B19 detected by single-stranded conformational polymorphism assay (SSCP) and partial nucleotide sequencing.

D. Middleton, D. Erdman, J. Moore, 1995, Journal of virological methods.

Are human platelet alloantigens (HPA) minor transplantation antigens in clinical bone marrow transplantation?

D. Middleton, M. Karas, B. Labar, 2003, Bone Marrow Transplantation.

Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations

Andrew R. Jones, Faviel F. Gonzalez-Galarza, Louise Y. C. Takeshita, 2014, Nucleic Acids Res..

The repercussions of implementing flow cytometry as a single HLA antibody screening technique in prospective renal transplant recipients

D. Middleton, B. Magee, Jeanie Martin, 2006, Transplant international : official journal of the European Society for Organ Transplantation.

Natural inactivation of a common HLA allele (A*2402) has occurred on at least three separate occasions.

E. Adams, P. Parham, J. McCluskey, 1997, Journal of immunology.

Frequencies of HLA-A, HLA-B, HLA-DR, and HLA-DQ phenotypes in the United Arab Emirates population.

D. Middleton, V. Valluri, L. Abdel-Wareth, 2005, Tissue antigens.

Allele Frequencies Net Database: Improvements for storage of individual genotypes and analysis of existing data.

Andrew R Jones, Derek Middleton, Faviel F Gonzalez-Galarza, 2016, Human immunology.

Frequency and associations of HLA class II TaqI allogenotypes in the Northern Ireland population.

D. Middleton, D. Savage, C. Cullen, 1990, Human immunology.

Diagnostic PCR with Leishmania donovani specificity using sequences from the variable region of kinetoplast minicircle DNA

S. Sundar, D. Middleton, Neeloo Singh, 1999, Tropical medicine & international health : TM & IH.

Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002

Bo Dupont, Derek Middleton, John Trowsdale, 2003, Immunogenetics.

Molecular variation at the HLA-A, B, C, DRB1, DQA1, and DQB1 loci in full heritage American Indians in Arizona: private haplotypes and their evolution.

W. Knowler, D. Middleton, M. Trucco, 2009, Tissue antigens.

Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop.

Wesley M. Marin, M. Petzl-Erler, P. Parham, 2018, Human immunology.

HLA class I allele distribution of a Hong Kong Chinese population based on high-resolution PCR-SSOP typing.

D. Middleton, A. Arnaiz-Villena, F. Williams, 2004, Tissue antigens.

HLA polymorphisms in Cabo Verde and Guiné-Bissau inferred from sequence-based typing.

D. Middleton, A. Brehm, J. Bruges-Armas, 2005, Human immunology.

Development of PCR-SSOP for HLA-A typing of bone marrow registry donors.

D. Middleton, F. Williams, E. Mallon, 1997, Tissue antigens.

Modification of an HLA-B PCR-SSOP typing system leading to improved allele determination.

D. Middleton, F. Williams, E. Mallon, 1995, Tissue antigens.

Detection of HLA-A*24 null alleles by DNA typing methods.

D. Middleton, F. Williams, M. Curran, 1998, Tissue antigens.

Differential RNA expression of KIR alleles

D. Middleton, A. Meenagh, Asensio A. Gonzalez, 2010, Immunogenetics.

A common KIR2DS4 deletion variant in the human that predicts a soluble KIR molecule analogous to the KIR1D molecule observed in the rhesus monkey.

D Middleton, D. Middleton, M D Curran, 2002, Tissue antigens.

Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA.

S Tonks, J A Hollenbach, D Middleton, 2010, Tissue antigens.

Analysis of the HLA population data (AHPD) submitted to the 15th International Histocompatibility/Immunogenetics Workshop by using the Gene[rate] computer tools accommodating ambiguous data (AHPD project report).

D Middleton, A. Sanchez‐Mazas, M. Currat, 2010, Tissue antigens.

A bioinformatics approach to ascertaining the rarity of HLA alleles.

M Setterholm, S G E Marsh, D Middleton, 2008, Tissue antigens.

Distribution of HLA alleles in Portugal and Cabo Verde. Relationships with the slave trade route.

D. Middleton, A. Brehm, F. Williams, 2002, Annals of human genetics.

Distribution of HLA alleles in Portugal and Cabo Verde. Relationships with the slave trade route

D. Middleton, A. Brehm, F. Williams, 2002, Annals of human genetics.

Frequency of cytokine polymorphisms in populations from western Europe, Africa, Asia, the Middle East and South America.

M. Hammond, D. Middleton, A. Meenagh, 2002, Human immunology.

Genetic association studies of tumour necrosis factor α and β and tumour necrosis factor receptor 1 and 2 polymorphisms across the clinical spectrum of multiple sclerosis

D. Middleton, C. Patterson, G. McDonnell, 1999, Journal of Neurology.

KIR allele and gene polymorphism group (KAG).

D. Middleton, 2005, Molecular immunology.

Community standards: a new policy to ensure consistency and transparency in immunogenomics

D. Middleton, P. Travers, 2012, International journal of immunogenetics.

HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish

D. Middleton, Y. Barnett, O. Ross, 2003, Mechanisms of Ageing and Development.

A Proteome-Wide Immunoinformatics Tool to Accelerate T-Cell Epitope Discovery and Vaccine Design in the Context of Emerging Infectious Diseases: An Ethnicity-Oriented Approach

B. Kobe, D. Middleton, F. Gonzalez-Galarza, 2021, Frontiers in Immunology.

Association of Killer Cell Immunoglobulin-Like Receptor Genes with Hodgkin's Lymphoma in a Familial Study

J. Nicolas, L. Abel, D. Middleton, 2007, PloS one.

Analysis of the distribution of HLA-B alleles in populations from five continents.

D Middleton, A. Daar, M. Hammond, 2000, Human immunology.

Distribution of HLA-A alleles in eight ethnic groups from Pakistan.

S. Q. Mehdi, D. Middleton, A. Mohyuddin, 2003, Tissue antigens.

PCR-SSOP TYPING

D. Middleton, 2000 .

Frequency of HLA-A and B alleles in early and late-onset Alzheimer's disease

P. Ince, D. Middleton, J. Edwardson, 1999, Neuroscience Letters.

HLA-A towards a high-resolution DNA typing.

D. Middleton, M. Tilanus, F. Williams, 1998, Tissue antigens.

A Bw6-associated B44 allele (B*4409) identified by SSOP and corresponding serological results.

D. Middleton, F. Williams, M. Curran, 1997, Tissue antigens.

Identification of a new HLA-B allele, HLA-B*0708.

D. Middleton, F. Williams, M. Curran, 1997, Tissue antigens.

Molecular typing of HLA class I and class II antigens in Indian kala‐azar patients

S. Sundar, D. Middleton, S. Agrawal, 1997, Tropical medicine & international health : TM & IH.

Development of PCR-SSOP for the identification of HLA-A*02 subtypes and determination of HLA-A*02 frequencies within different ethnic populations.

J. Fitzgerald, D. Middleton, S. Urbaniak, 1997, Tissue antigens.

Frequency of cytokine gene promoter polymorphisms in the Northern Ireland cystic fibrosis population.

D. Middleton, J. Elborn, M. Ennis, 2007, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Investigation of KIR gene frequencies in type 1 diabetes mellitus.

D. Middleton, A. Meenagh, E. Tuomilehto-Wolf, 2006, Human immunology.

High resolution HLA-DRB1 identification of a Caucasian population.

G. Thomson, D. Middleton, R. Single, 2004, Human immunology.

Increased frequency of the 2437T allele of the heat shock protein 70-Hom gene in an aged Irish population

D. Middleton, Y. Barnett, O. Ross, 2003, Experimental Gerontology.

Molecular diversity of the HLA-C gene identified in a caucasian population.

D. Middleton, A. Meenagh, F. Williams, 2002, Human immunology.

HLA Typing From Serology to Molecular Biology

D. Middleton, 1997 .

HLA IN KIDNEY TRANSPLANTATION

D. Middleton, 1997 .

HLA-A, -B and -DRB1 genotyping and haplotype frequencies of 3892 cord blood units in the Hong Kong Chinese Cord Blood Registry.

D. Middleton, M. Guo, Wanling Yang, 2016, Human immunology.

HLA-A, -B, -C, and -DRB1 genotyping and haplotype frequencies for a Hong Kong Chinese population of 7595 individuals.

D. Middleton, M. Guo, Wanling Yang, 2016, Human immunology.

Analysis of the distribution of HLA-A alleles in populations from five continents.

D Middleton, A. Daar, M. Hammond, 2000, Human immunology.

HLA-A and -B alleles in a population from Belo Horizonte, Brazil

D. Middleton, F. Williams, E. Nascimento, 2004 .

Characterization of kinetoplast DNA minicircles of an Indian isolate of Leishmania donovani.

D. Middleton, M. Curran, N. Singh, 1999, Acta tropica.

Should HLA Mismatch Acceptability for Sensitized Transplant Candidates Be Determined at the High‐Resolution Rather Than the Antigen Level?

J. Friedewald, P. Nickerson, S. Fuggle, 2015, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Towards uniformity in the definition of acceptable mismatches for highly sensitized patients

S. Fuggle, D. Roelen, F. Claas, 2019, HLA.

High‐Resolution HLA Typing for Sensitized Patients: Advances in Medicine and Science Require Us to Challenge Existing Paradigms

J. Friedewald, P. Nickerson, S. Fuggle, 2015, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Antigen Society #14 Report (B40 CREG, BW60, BW61, BW41, BW48, B13)

K. Tokunaga, D. Middleton, K. Sakagami, 1989 .

Identification of Dw2, Dw12, and “Short” DR2 Splits with Sequential Exon-Specific DRβ, DQβ, and DQα cDNA Probes

D. Middleton, J. Bidwell, D. Savage, 1989 .

Genetic polymorphism of IL-12 p40 gene in immune-mediated disease

D. Middleton, M. Hall, H. Moutsopoulos, 2000, Genes and Immunity.

Association between polymorphism in regulatory region of gene encoding tumour necrosis factor α and risk of Alzheimer's disease and vascular dementia: a case-control study

D. Middleton, C. Patterson, C. D. McCullagh, 2001, The Lancet.

Association between polymorphism in regulatory region of gene encoding tumour necrosis factor alpha and risk of Alzheimer's disease and vascular dementia: a case-control study.

D. Middleton, C. Patterson, C. D. McCullagh, 2001, Lancet.

Intravascular Large B-Cell Lymphoma: A Diagnostic Dilemma

D. Middleton, M. Veeraputhiran, Yadav Pandey, 2021, Cureus.

'Immunogenetics of Aging': report on the activities of the 15th International HLA and Immunogenetics Working Group and 15th International HLA and Immunogenetics Workshop.

D Middleton, G Pawelec, C. Franceschi, 2011, Tissue antigens.

Sources of HLA typing sera.

D. Middleton, S. Nelson, J. Martin, 1978, The Ulster medical journal.

Allele Frequencies Database

D. Middleton, F. Gonzalez-Galarza, L. Takeshita, 2014, Transfusion Medicine and Hemotherapy.

Predictive immunogenetic markers in COVID-19

D. Middleton, F. Gonzalez-Galarza, E. Santos, 2021, Human Immunology.

HLA Matching in Pediatric Kidney Transplantation: HLA Poorly Matched Living Donor Transplants Versus HLA Well-Matched Deceased Donor Transplants

D. Middleton, G. Opelz, C. Süsal, 2017, Transplantation.

Analysis of killer immunoglobulin-like receptor genes in ankylosing spondylitis

D Middleton, C. Farrar, M. Brown, 2008, Annals of the rheumatic diseases.

Characterisation of a new HLA-B allele, HLA-B*0724.

D. Middleton, J. Anholts, G. Schreuder, 2001, Tissue antigens.

Characterization of HLA-B*3921 and confirmation of HLA-B*4415, two variant HLA-B alleles identified in the Omani population.

A. Daar, D. Middleton, F. Williams, 2000, Tissue antigens.

TRANSFUSION OF ONE HLA‐DR ANTIGEN‐MATCHED BLOOD TO POTENTIAL RECIPIENTS OF A RENAL ALLOGRAFT

D. Middleton, J. Douglas, Jeanie Martin, 1994, Transplantation.

Effect on sensitisation of giving HLA-DR-matched blood to potential renal transplant recipients.

D. Middleton, J. Douglas, J. Martin, 1992, Transplantation proceedings.

mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson's disease in the Irish

D. Middleton, Y. Barnett, O. Ross, 2003, Experimental Gerontology.

Yellow fever vaccination

D. Middleton, 1999, The Lancet.

People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population

P. Donnelly, D. Davison, T. Frayling, 2011, European Journal of Human Genetics.

Mutation screening in exons 3 and 4 of α‐synuclein in sporadic Parkinson's and sporadic and familial dementia with Lewy bodies cases

E. Jaros, D. Middleton, R. Perry, 1998 .

TEN-YEAR RESULTS OF RENAL TRANSPLANTATION WITH AZATHIOPRINE AND PREDNISOLONE AS ONLY IMMUNOSUPPRESSION

D. Middleton, C. Hill, M. Mcgeown, 1988, The Lancet.

Mitochondrial DNA damage in lymphocytes: a role in immunosenescence?

G. Pawelec, B. Johansson, D. Middleton, 2002, Experimental Gerontology.

Parvovirus B19 and Chronic Fatigue Syndrome

D. Middleton, P. Behan, W. Behan, 1997 .

No association of HLA class II antigens in chronic fatigue syndrome.

D. Middleton, D. Savage, D. Smith, 1991, Disease markers.

Increased frequencies of activating natural killer receptors are associated with liver injury in individuals who do not eliminate hepatitis C virus.

D. Middleton, F. Williams, N. Paladino, 2007, Tissue antigens.

History of DNA typing for the human MHC.

D. Middleton, 1999, Reviews in immunogenetics.

HLA antigen frequency of Northern Ireland blood donors.

D. Middleton, J. Martin, 1978, The Ulster medical journal.

Identification of medically important pathogenic fungi by reference strand-mediated conformational analysis (RSCA).

J. G. Barr, J. Madrigal, M. McMullin, 2002, Journal of medical microbiology.

Nothing's perfect: the art of defining HLA-specific antibodies.

D. Middleton, D. Lowe, J. Jones, 2014, Transplant immunology.

Nothing ' s perfect : The art of de fi ning HLA-speci fi c antibodies

D. Middleton, D. Lowe, J. Jones, 2014 .

One thousand renal transplants in Belfast (1968-1998).

D. Middleton, G. Opelz, M. Mcgeown, 2004, Clinical transplants.

Defining HLA‐Specific Antibodies

D. Middleton, D. Lowe, J. Jones, 2014, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Genetic association studies of tumour necrosis factor alpha and beta and tumour necrosis factor receptor 1 and 2 polymorphisms across the clinical spectrum of multiple sclerosis.

D. Middleton, C. Patterson, G. McDonnell, 1999, Journal of neurology.

A novel polymorphic triplet repeat in intron five of the &agr;-synuclein gene: no evidence of expansion or allelic association with idiopathic Parkinson's disease in the Irish

D. Middleton, Y. Barnett, O. Ross, 2002, Neuroreport.

A web resource for mining HLA associations with adverse drug reactions: HLA-ADR

Andrew R. Jones, Yenal Dundar, Faviel F. Gonzalez-Galarza, 2016, Database J. Biol. Databases Curation.

Analysis of KIR Ligand Incompatibility in Human Renal Transplantation

D. Middleton, G. Opelz, G. Laux, 2005, Transplantation.

HLA tissue typing and chronic vulval dystrophy

D. Middleton, J. Pinkerton, H. A. Lavery, 1984, British journal of obstetrics and gynaecology.

Immunogenetics: Advances and Education

T. Nánási, D. Middleton, D. Charron, 1997 .