C. J. O’Donnell

发表

Synthetic approaches to the 2009 new drugs.

Jin Li, Kevin K-C Liu, K. Liu, 2011, Bioorganic & medicinal chemistry.

Synthetic approaches to the 2011 new drugs.

K. Liu, S. Sakya, C. J. O’Donnell, 2013, Bioorganic & medicinal chemistry.

Synthesis of 3-methoxy-9-(3,4,5-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-ol, a potent antineoplastic benzosuberene derivative for anti-cancer chemotherapy

C. J. O’Donnell, A. Maderna, Zecheng Chen, 2012 .

RN927C, a Site-Specific Trop-2 Antibody–Drug Conjugate (ADC) with Enhanced Stability, Is Highly Efficacious in Preclinical Solid Tumor Models

M. Dorywalska, A. Rajpal, J. Pons, 2016, Molecular Cancer Therapeutics.

Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates.

M. Dorywalska, J. Chaparro-Riggers, A. Rajpal, 2013, Chemistry & biology.

Synthetic Approaches to the New Drugs Approved During 2015.

K. Liu, C. J. O’Donnell, Andrew C. Flick, 2017, Journal of medicinal chemistry.

Synthetic approaches to the 2007 new drugs.

K. Liu, S. Sakya, C. J. O’Donnell, 2008, Mini reviews in medicinal chemistry.

Synthetic approaches to the 2008 new drugs.

K. Liu, S. Sakya, C. J. O’Donnell, 2009, Mini reviews in medicinal chemistry.

Novel PIKK inhibitor antibody-drug conjugates: Synthesis and anti-tumor activity.

F. Loganzo, C. J. O’Donnell, E. Graziani, 2019, Bioorganic & medicinal chemistry letters.

The discovery and characterization of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiator N-{(3S,4S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242).

J. Pandit, R. Hurst, M. Hajós, 2015, Journal of medicinal chemistry.

Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists.

R. J. Mather, C. J. O’Donnell, Frank M Nedza, 2009, Bioorganic & medicinal chemistry letters.

Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate

F. Loganzo, C. J. O’Donnell, J. Lucas, 2017, PloS one.

Development of Highly Optimized Antibody–Drug Conjugates against CD33 and CD123 for Acute Myeloid Leukemia

F. Loganzo, C. J. O’Donnell, A. Maderna, 2020, Clinical Cancer Research.

Activation of lipolysis and cyclic AMP accumulation in rabbit adipocytes by isoproterenol in the presence of forskolin or pertussis toxin.

C. J. O’Donnell, J. Fain, I. Mills, 1984, Biochimica et biophysica acta.

Pertussis toxin reverses Gpp(NH)p inhibition of basal and forskolin activated adipocyte adenylate cyclase.

C. J. O’Donnell, J. Fain, I. Mills, 1983, Biochemical and biophysical research communications.

Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design

M. Dorywalska, A. Rajpal, J. Pons, 2016, Molecular Cancer Therapeutics.

PF-06804103, A Site-specific Anti-HER2 Antibody–Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers

F. Loganzo, C. J. O’Donnell, J. Lucas, 2020, Molecular Cancer Therapeutics.

Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate–dependent dioxygenase

C. J. O’Donnell, F. Koehn, Alessandra S. Eustáquio, 2014, Proceedings of the National Academy of Sciences.

Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism

S. C. K. Sukuru, F. Loganzo, C. J. O’Donnell, 2016, ACS medicinal chemistry letters.

Analogues de splicéostatine

C. J. O’Donnell, S. Puthenveetil, F. Koehn, 2013 .

Synthetic Approaches to the New Drugs Approved During 2020.

C. J. O’Donnell, C. Leverett, S. Berritt, 2022, Journal of medicinal chemistry.

A general route to the synthesis of 1,5-methano- and 1,5-ethano- 2,3,4,5-tetrahydro-1H-3-benzazepines.

C. J. O’Donnell, R. Singer, J. D. Mckinley, 2004, The Journal of organic chemistry.

Aza-cope rearrangement-mannich cyclizations for the formation of complex tricyclic amines: stereocontrolled total synthesis of (+/-)-gelsemine.

L. Overman, C. J. O’Donnell, G. P. Meier, 2005, Journal of the American Chemical Society.

Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.

Gregory W. Kauffman, L. Pustilnik, A. Stepan, 2015, ACS medicinal chemistry letters.

Synthetic approaches to the 2013 new drugs.

K. Liu, C. J. O’Donnell, C. Leverett, 2015, Bioorganic & medicinal chemistry.

Synthetic approaches to the 2014 new drugs.

K. Liu, C. J. O’Donnell, C. Leverett, 2016, Bioorganic & medicinal chemistry.

Kinetically guided radical-based synthesis of C(sp3)−C(sp3) linkages on DNA

Jie Wang, Stephen Brown, William Farrell, 2018, Proceedings of the National Academy of Sciences.

Synthetic approaches to the 2010 new drugs.

Kevin K-C Liu, K. Liu, S. Sakya, 2012, Bioorganic & medicinal chemistry.

Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.

R. J. Mather, Anne W. Schmidt, R. Hurst, 2010, Journal of medicinal chemistry.

Totalsynthese von (±)‐Gelsemin

L. Overman, C. J. O’Donnell, M. Sharp, 1999 .

Synthetic Approaches to the New Drugs Approved During 2018.

C. J. O’Donnell, C. Leverett, Hong X. Ding, 2020, Journal of medicinal chemistry.

Synthetic Approaches to the New Drugs Approved During 2017.

Emma McInturff, Carolyn A Leverett, Christopher J Helal, 2019, Journal of medicinal chemistry.

Use of the intramolecular Heck reaction for forming congested quaternary carbon stereocenters. Stereocontrolled total synthesis of (+/-)-gelsemine.

L. Overman, C. J. O’Donnell, M. Sharp, 2005, Journal of the American Chemical Society.

Synthesis of cyclic hydropyran oligolides with convergent amine, amide, phosphonate and furan appendages

C. J. O’Donnell, S. D. Burke, G. Packard, 1997 .

Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor.

Gregory W. Kauffman, Chakrapani Subramanyam, L. Pustilnik, 2012, Journal of medicinal chemistry.

Synthetic approaches to the 2012 new drugs.

Kevin K-C Liu, Carolyn A Leverett, K. Liu, 2014, Bioorganic & medicinal chemistry.

Cytotoxic Spliceostatins from Burkholderia sp. and Their Semisynthetic Analogues.

F. Loganzo, C. J. O’Donnell, F. Koehn, 2014, Journal of natural products.

Investigational antibody drug conjugates for solid tumors

C. J. O’Donnell, H. Gerber, P. Sapra, 2011, Expert opinion on investigational drugs.

A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions

Samuel A. Williams, O. Foord, M. Aujay, 2017, Science Translational Medicine.

NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells

C. J. O’Donnell, A. Maderna, Wenyan Zhong, 2021, Cell reports. Medicine.

Tumor Cells Chronically Treated with a Trastuzumab–Maytansinoid Antibody–Drug Conjugate Develop Varied Resistance Mechanisms but Respond to Alternate Treatments

M. Follettie, F. Loganzo, E. Melamud, 2015, Molecular Cancer Therapeutics.

Discovery of Cytotoxic Dolastatin 10 Analogues with N-Terminal Modifications

Sai Chetan K. Sukuru, Frank Loganzo, Michael J. Shapiro, 2015 .

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.

Frank Loganzo, Carolyn A Leverett, Chakrapani Subramanyam, 2014, Journal of medicinal chemistry.

Novel Anti-TM4SF1 Antibody–Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature

Anson K. Abraham, H. Dvorak, L. Zawel, 2015, Molecular Cancer Therapeutics.

Long-term Tumor Regression Induced by an Antibody–Drug Conjugate That Targets 5T4, an Oncofetal Antigen Expressed on Tumor-Initiating Cells

R. Abraham, C. J. O’Donnell, J. Lucas, 2012, Molecular Cancer Therapeutics.

Discovery and characterization of a novel dihydroisoxazole class of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiators.

J. Pandit, R. Hurst, M. Hajós, 2013, Journal of medicinal chemistry.

Development of Solid-Phase Site-Specific Conjugation and Its Application toward Generation of Dual Labeled Antibody and Fab Drug Conjugates.

F. Loganzo, C. J. O’Donnell, E. Graziani, 2016, Bioconjugate chemistry.

Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates

F. Loganzo, C. J. O’Donnell, E. Graziani, 2017, The AAPS Journal.

A facile synthesis of 2,3-azaisoindoline

S. Sakya, C. J. O’Donnell, Kees Pouwer, 2010 .

Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate.

J. Pandit, W. Hoffman, M. Hajós, 2018, Journal of medicinal chemistry.

Design, synthesis, and pharmacological evaluation of azetedine and pyrrolidine derivatives as dual norepinephrine reuptake inhibitors and 5-HT(1A) partial agonists.

C. J. O’Donnell, David L. Gray, B. Campbell, 2011, Bioorganic & medicinal chemistry letters.

Large Molecule Therapeutics Discovery & Preclinical Development Long-term Tumor Regression Induced by an Antibody – Drug Conjugate That Targets 5 T 4 , anOncofetal AntigenExpressed on Tumor-Initiating Cells

R. Abraham, C. J. O’Donnell, J. Lucas, 2013 .

Natural Product Splicing Inhibitors: A New Class of Antibody-Drug Conjugate (ADC) Payloads.

Frank Loganzo, Tracey Clark, L. Nathan Tumey, 2016, Bioconjugate chemistry.

Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody-Drug Conjugates.

F. Loganzo, C. J. O’Donnell, J. Lucas, 2018, Bioconjugate chemistry.

Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators.

Gregory W. Kauffman, L. Pustilnik, S. Sakya, 2014, Journal of medicinal chemistry.

Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators.

Gregory W. Kauffman, L. Pustilnik, S. Sakya, 2012, Bioorganic & medicinal chemistry letters.

Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors.

L. Pustilnik, A. Stepan, R. Obach, 2011, Journal of medicinal chemistry.

Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads.

J. Pandit, S. C. K. Sukuru, K. Parris, 2016, ACS medicinal chemistry letters.

Synthetic Approaches to the New Drugs Approved during 2019.

C. J. O’Donnell, C. Leverett, S. Berritt, 2021, Journal of medicinal chemistry.

Synthetic Approaches to New Drugs Approved During 2016.

C. J. O’Donnell, C. Leverett, Andrew C Flick, 2018, Journal of medicinal chemistry.

Synthetic Approaches to the New Drugs Approved During 2021.

C. J. O’Donnell, C. Leverett, S. Berritt, 2023, Journal of medicinal chemistry.

Synthetic Approaches to the New Drugs Approved During 2015.

K. Liu, C. J. O’Donnell, C. Leverett, 2017, Journal of medicinal chemistry.

Abstract 4629: Tumor cells selected for resistance to an antibody-drug conjugate retain sensitivity to ADCs with modified linkers and payloads.

M. Follettie, F. Loganzo, C. J. O’Donnell, 2013 .