P. Deen

发表

Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption

M. Boone, P. Deen, J. Banga, 2008, Pflügers Archiv - European Journal of Physiology.

Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5

P. Deen, J. Roche, Sabeen Survery, 2017, The Journal of Biological Chemistry.

Cell-biologic and functional analyses of five new Aquaporin-2 missense mutations that cause recessive nephrogenic diabetes insipidus.

D. Bichet, P. Deen, D. Landau, 2002, Journal of the American Society of Nephrology : JASN.

Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells.

P. Deen, F. Russel, J. B. Koenderink, 1998, Molecular pharmacology.

Quaternary Ammonium Compounds as Water Channel Blockers

B. L. de Groot, H. Grubmüller, P. Deen, 2006, Journal of Biological Chemistry.

Defective Processing and Trafficking of Water Channels in Nephrogenic Diabetes insipidus

P. Deen, C. van Os, E. Kamsteeg, 2000, Nephron Experimental Nephrology.

New mutations in the AQP2 gene in nephrogenic diabetes insipidus resulting in functional but misrouted water channels.

P. Deen, N. Knoers, L. Monnens, 1997, Journal of the American Society of Nephrology : JASN.

The aquaporin-2 water channel in autosomal dominant primary nocturnal enuresis.

M. Caplan, P. Deen, N. Dahl, 2002, Journal of Urology.

Hypertonicity Is Involved in Redirecting the Aquaporin-2 Water Channel into the Basolateral, Instead of the Apical, Plasma Membrane of Renal Epithelial Cells*

B. W. van Balkom, Dennis Brown, P. Deen, 2003, The Journal of Biological Chemistry.

Patients with autosomal nephrogenic diabetes insipidus homozygous for mutations in the aquaporin 2 water-channel gene.

B. V. van Oost, P. Deen, L. Monnens, 1994, American journal of human genetics.

An impaired routing of wild‐type aquaporin‐2 after tetramerization with an aquaporin‐2 mutant explains dominant nephrogenic diabetes insipidus

P. Deen, C. van Os, E. Kamsteeg, 1999, The EMBO journal.

The Subcellular Localization of an Aquaporin-2 Tetramer Depends on the Stoichiometry of Phosphorylated and Nonphosphorylated Monomers

P. Deen, C. van Os, E. Kamsteeg, 2000, The Journal of cell biology.

Functionality of aquaporin-2 missense mutants in recessive nephrogenic diabetes insipidus

P. Deen, C. van Os, E. Kamsteeg, 2001, Pflügers Archiv.

The Role of Putative Phosphorylation Sites in the Targeting and Shuttling of the Aquaporin-2 Water Channel*

S. Nielsen, B. W. van Balkom, P. Deen, 2002, The Journal of Biological Chemistry.

Reversed polarized delivery of an aquaporin-2 mutant causes dominant nephrogenic diabetes insipidus

D. Bichet, P. Deen, C. van Os, 2003, The Journal of cell biology.

Role of cytoplasmic termini in sorting and shuttling of the aquaporin-2 water channel.

P. Sluijs, B. W. van Balkom, P. Deen, 2004, American journal of physiology. Cell physiology.

Pharmacological Chaperones in Nephrogenic Diabetes Insipidus

P. Deen, J. Robben, 2012, BioDrugs.

Aquaporines in de nier en hun rol in nefrogene diabetes insipidus

P. Deen, J. Robben, N. Knoers, 2006 .

nephrogenic diabetes insipidus receptor and aquaporin 2 water channel in Cell biological aspects of the vasopressin type-2

P. Deen, N. Knoers, J. Robben, 2006 .

Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus.

P. Deen, N. Knoers, J. Robben, 2006, American journal of physiology. Renal physiology.

Aquaporins: water selective channels in biological membranes. Molecular structure and tissue distribution.

P. Deen, C. Os, J. Dempster, 1994, Biochimica et biophysica acta.

Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel

G. Hendriks, M. Boone, P. Deen, 2006, Proceedings of the National Academy of Sciences.

SUCNR1-mediated chemotaxis of macrophages aggravates obesity-induced inflammation and diabetes

M. Netea, G. Hooiveld, U. Engelke, 2017, Diabetologia.

Genetic analysis of mice strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation

R. Korstanje, P. Deen, S. Tsaih, 2011, Physiological genomics.

therapy of nephrogenic diabetes insipidus in MDCK cells by pharmacochaperones: relevance to Functional rescue of vasopressin V2 receptor mutants

Kazuhiro Takahashi, P. Deen, N. Knoers, 2012 .

Intracellular activation of vasopressin V2 receptor mutants in nephrogenic diabetes insipidus by nonpeptide agonists

G. Milligan, P. Deen, N. Knoers, 2009, Proceedings of the National Academy of Sciences.

Functional rescue of vasopressin V2 receptor mutants in MDCK cells by pharmacochaperones: relevance to therapy of nephrogenic diabetes insipidus.

P. Deen, N. Knoers, M. Sze, 2007, American journal of physiology. Renal physiology.

Characterization of vasopressin V2 receptor mutants in nephrogenic diabetes insipidus in a polarized cell model.

P. Deen, N. Knoers, J. Robben, 2005, American journal of physiology. Renal physiology.

Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice

R. Korstanje, P. Deen, Lars Damen, 2017, PloS one.

Amiloride blocks lithium entry through the sodium channel thereby attenuating the resultant nephrogenic diabetes insipidus.

J. Wetzels, P. Deen, B. Rossier, 2009, Kidney international.

Aquaporin-2 Levels in vitro and in vivo are Regulated by VACM-1, a Cul 5 Gene

Gary L. Dewey, P. Deen, B. Andresen, 2012, Cellular Physiology and Biochemistry.

The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain.

P. Agre, P. Deen, J. Jung, 1996, Proceedings of the National Academy of Sciences of the United States of America.

MAL decreases the internalization of the aquaporin-2 water channel

P. Pagel, M. Caplan, P. Deen, 2007, Proceedings of the National Academy of Sciences.

Physiological relevance of aquaporins: luxury or necessity?

P. Deen, C. van Os, E. Kamsteeg, 2000, Pflügers Archiv.

AQP2 Abundance is Regulated by the E3-Ligase CHIP Via HSP70

Annarita Di Mise, G. Tamma, M. Ranieri, 2017, Cellular Physiology and Biochemistry.

Molecular and cellular defects in nephrogenic diabetes insipidus

P. Deen, N. Knoers, 2001, Pediatric Nephrology.

Nephrogenic diabetes insipidus.

B. W. van Balkom, P. Deen, E. Kamsteeg, 2000, Current opinion in nephrology and hypertension.

Regulation of AQP2 localization by S256 and S261 phosphorylation and ubiquitination.

G. Tamma, M. Boone, P. Deen, 2011, American journal of physiology. Cell physiology.

Lithium in the Kidney: Friend and Foe?

P. Deen, R. Baumgarten, T. de Groot, 2016, Journal of the American Society of Nephrology : JASN.

Thiazide-induced hyponatraemia is associated with increased water intake and impaired urea-mediated water excretion at low plasma antidiuretic hormone and urine aquaporin-2

P. Deen, M. Levi, B. H. van den Born, 2015, Journal of Hypertension.

Missorting of the Aquaporin-2 mutant E258K to multivesicular bodies/lysosomes in dominant NDI is associated with its monoubiquitination and increased phosphorylation by PKC but is due to the loss of E258

P. Sluijs, G. Hendriks, P. Deen, 2008, Pflügers Archiv - European Journal of Physiology.

Routing of the aquaporin-2 water channel in health and disease.

B. W. van Balkom, P. Deen, E. Kamsteeg, 2000, European journal of cell biology.

Apical and basolateral expression of Aquaporin-1 in transfected MDCK and LLC-PK cells and functional evaluation of their transcellular osmotic water permeabilities

S. Nielsen, P. Deen, R. Bindels, 1997, Pflügers Archiv.

The exchange of functional domains among aquaporins with different transport characteristics

P. Deen, C. van Os, S. Mulders, 1998, Pflügers Archiv.

Collecting duct principal cell transport processes and their regulation.

D. Kohan, P. Deen, D. Pearce, 2015, Clinical journal of the American Society of Nephrology : CJASN.

Chapter 6 Trafficking of native and mutant mammalian MIP proteins

P. Deen, Dennis Brown, 2001 .

Glycosylation is not essential for vasopressin-dependent routing of aquaporin-2 in transfected Madin-Darby canine kidney cells.

J. Wetzels, P. Deen, C. van Os, 1998, Journal of the American Society of Nephrology : JASN.

Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus.

J. Wetzels, O. Devuyst, P. Deen, 2016, Journal of the American Society of Nephrology : JASN.

Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption

M. Boone, P. Deen, 2008, Pflügers Archiv - European Journal of Physiology.

Functional rescue of vasopressin V2 receptor mutants in MDCK cells by pharmacochaperones: relevance to therapy of nephrogenic diabetes insipidus

Kazuhiro Takahashi, P. Deen, N. Knoers, 2006 .

Vasopressin Type-2 Receptor and Aquaporin-2 Water Channel Mutants in Nephrogenic Diabetes Insipidus

P. Deen, N. Knoers, 1998 .

In mpkCCD cells, long-term regulation of aquaporin-2 by vasopressin occurs independent of protein kinase A and CREB but may involve Epac.

J. Wetzels, P. Deen, M. Kortenoeven, 2012, American journal of physiology. Renal physiology.

The physiological implication of novel proteins in systemic osmoregulation

P. Deen, Anne P. Sinke, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Development of lithium-induced nephrogenic diabetes insipidus is dissociated from adenylyl cyclase activity.

P. Deen, A. Vandewalle, E. Kamsteeg, 2006, Journal of the American Society of Nephrology : JASN.

Lithium reduces aquaporin-2 transcription independent of prostaglandins.

J. Wetzels, P. Deen, M. Kortenoeven, 2012, American journal of physiology. Cell physiology.

Time-dependent regulation by aldosterone of the amiloride-sensitive Na+ channel in rabbit kidney

P. Deen, R. Bindels, A. Hartog, 1999, Pflügers Archiv.

Small-molecule screening identifies modulators of aquaporin-2 trafficking.

B. Wiesner, G. Valenti, P. Deen, 2013, Journal of the American Society of Nephrology.

Hydrochlorothiazide attenuates lithium-induced nephrogenic diabetes insipidus independently of the sodium-chloride cotransporter.

J. Wetzels, O. Devuyst, P. Deen, 2014, American journal of physiology. Renal physiology.

Aquaporin-2 transfection of Madin-Darby canine kidney cells reconstitutes vasopressin-regulated transcellular osmotic water transport.

R. Errington, P. Deen, C. van Os, 1997, Journal of the American Society of Nephrology : JASN.

Localization of the succinate receptor in the distal nephron and its signaling in polarized MDCK cells.

G. Milligan, P. Deen, R. Fenton, 2009, Kidney international.

Rescue of vasopressin V2 receptor mutants by chemical chaperones: specificity and mechanism.

P. Deen, N. Knoers, M. Sze, 2005, Molecular biology of the cell.

Renal expression of exchange protein directly activated by cAMP (Epac) 1 and 2.

Emile de Heer, P. Deen, L. Price, 2008, American journal of physiology. Renal physiology.

Nucleotides downregulate aquaporin 2 via activation of apical P2 receptors.

M. Boone, P. Deen, R. Unwin, 2009, Journal of the American Society of Nephrology : JASN.

Polarisation, key to good localisation.

G. Hendriks, P. Deen, M. Devonald, 2006, Biochimica et biophysica acta.

Aquaporin-2: COOH terminus is necessary but not sufficient for routing to the apical membrane.

M. Jennings, B. W. van Balkom, M. Caplan, 2002, American journal of physiology. Renal physiology.

Large‐scale purification of functional recombinant human aquaporin‐2

A. Engel, P. Deen, J. B. Koenderink, 2001, FEBS letters.

The lysosomal trafficking regulator interacting protein-5 localizes mainly in epithelial cells

A. Mobasheri, M. Boone, P. Deen, 2010, Journal of Molecular Histology.

Assignment of the canalicular multispecific organic anion transporter gene (CMOAT) to human chromosome 10q24 and mouse chromosome 19D2 by fluorescent in situ hybridization.

M. Kool, P. Deen, R. Bindels, 1997, Cytogenetics and cell genetics.

Nephrogenic Diabetes Insipidus: Aquaporin-2 Defect

P. Deen, N. Knoers, C. V. Os, 2009 .

Aquaporin 2 mutations in nephrogenic diabetes insipidus.

P. Deen, N. Knoers, C. van Os, 2008, Seminars in nephrology.

Targeting the hepcidin-ferroportin axis may open the way to new interventions for the management of anemia of CKD ( 4 )

P. Deen, R. Fenton, E. Klussmann, 2012 .

Congenital nephrogenic diabetes insipidus: what can we learn from mouse models?

M. Boone, P. Deen, 2009, Experimental physiology.

Regulation of the vasopressin V2 receptor by vasopressin in polarized renal collecting duct cells.

P. Deen, N. Knoers, J. Robben, 2004, Molecular biology of the cell.

A Vasopressin-Induced Change in Prostaglandin Receptor Subtype Expression Explains the Differential Effect of PGE2 on AQP2 Expression

J. Wetzels, M. Boone, P. Deen, 2022, Frontiers in Physiology.

Pharmacological chaperones in nephrogenic diabetes insipidus: possibilities for clinical application.

P. Deen, J. Robben, 2007, BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy.

A novel mechanism in recessive nephrogenic diabetes insipidus: wild-type aquaporin-2 rescues the apical membrane expression of intracellularly retained AQP2-P262L.

D. Bichet, P. Deen, P. van der Sluijs, 2004, Human molecular genetics.

Characterization of the PKD 1 Gene Product, Polycystin-1

P. Courtoy, G. Germino, L. Onuchic, 2002 .

Urinary content of aquaporin 1 and 2 in nephrogenic diabetes insipidus.

P. Deen, C. van Os, R. A. van Aubel, 1996, Journal of the American Society of Nephrology : JASN.

(cid:2) ENaC-Mediated Lithium Absorption Promotes Nephrogenic Diabetes Insipidus

J. Stehle, P. Deen, J. Loffing, 2010 .

Role of aquaporins in renal water handling: physiology and pathophysiology.

P. Deen, C. van Os, 1998, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

The Succinate Receptor as a Novel Therapeutic Target for Oxidative and Metabolic Stress-Related Conditions

P. Deen, J. Robben, A. C. Ariza, 2012, Front. Endocrin..

Succinate receptors in the kidney.

P. Deen, J. Robben, 2011, Journal of the American Society of Nephrology : JASN.

Counteracting vasopressin-mediated water reabsorption by ATP, dopamine, and phorbol esters: mechanisms of action.

G. Tamma, M. Boone, P. Deen, 2011, American journal of physiology. Renal physiology.

At Physiological Expression Levels the Kidd Blood Group/Urea Transporter Protein Is Not a Water Channel*

P. Deen, J. Cartron, P. Ripoche, 1999, The Journal of Biological Chemistry.

Regulation of the Vasopressin V 2 Receptor by Vasopressin in Polarized Renal Collecting Duct Cells

P. Deen, N. Knoers, J. Robben, 2004 .

An aquaporin-2 water channel mutant which causes autosomal dominant nephrogenic diabetes insipidus is retained in the Golgi complex.

P. Sluijs, D. Bichet, P. Deen, 1998, The Journal of clinical investigation.

Glycosylation Is Important for Cell Surface Expression of the Water Channel Aquaporin-2 but Is Not Essential for Tetramerization in the Endoplasmic Reticulum*

B. W. van Balkom, G. Hendriks, P. Deen, 2004, Journal of Biological Chemistry.

Isolation of a cDNA for rat CHIP28 water channel: high mRNA expression in kidney cortex and inner medulla.

B. Wieringa, P. Deen, C. van Os, 1992, Biochemical and biophysical research communications.

Importance of the mercury-sensitive cysteine on function and routing of AQP1 and AQP2 in oocytes.

P. Deen, R. Bindels, A. Hartog, 1997, The American journal of physiology.

Localization of the human gene for aquaporin 3 (AQP3) to chromosome 9, region p21-->p12, using fluorescent in situ hybridization.

A. V. van Kessel, P. Deen, C. van Os, 1996, Cytogenetics and cell genetics.

Water channels encoded by mutant aquaporin-2 genes in nephrogenic diabetes insipidus are impaired in their cellular routing.

P. Deen, H. Croes, C. van Os, 1995, The Journal of clinical investigation.

X-ray structure of human aquaporin 2 and its implications for nephrogenic diabetes insipidus and trafficking

R. Neutze, P. Deen, K. Hedfalk, 2014, Proceedings of the National Academy of Sciences.

Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine.

B. V. van Oost, B. Wieringa, P. Deen, 1994, Science.

MicroRNA-132 controls water homeostasis through regulating MECP2-mediated vasopressin synthesis.

T. Rabelink, P. Deen, A. V. van Zonneveld, 2018, American journal of physiology. Renal physiology.

Molecular evolution of mammalian aquaporin-2: further evidence that elephant shrew and aardvark join the paenungulate clade.

G. Pesole, C. Saccone, O. Madsen, 1997, Molecular biology and evolution.

The proopiomelanocortin gene of Xenopus laevis

P. Deen, 1991 .

Dissociation between urine osmolality and urinary excretion of aquaporin-2 in healthy volunteers.

J. Wetzels, P. Deen, C. van Os, 2000, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Molecular and cellular defects in nephrogenic diabetes insipidus.

P. Deen, N. Knoers, C. van Os, 1996, Pediatric nephrology.

Epithelial aquaporins.

P. Deen, C. van Os, C H van Os, 1998, Current opinion in cell biology.

Vasopressin increases S261 phosphorylation in AQP2-P262L, a mutant in recessive nephrogenic diabetes insipidus.

P. Deen, R. Fenton, Dennis T M van den Berg, 2012, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

CO2 permeability of cell membranes is regulated by membrane cholesterol and protein gas channels

C. Supuran, Fabian Itel, W. Meier, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Yolk proteolysis and aquaporin-1o play essential roles to regulate fish oocyte hydration during meiosis resumption.

P. Deen, D. Raldúa, E. Lubzens, 2006, Developmental biology.

Marine Fish Egg Hydration Is Aquaporin-Mediated

D. Power, P. Deen, D. Raldúa, 2005, Science.

Isolation of a novel aquaglyceroporin from a marine teleost (Sparus auratus): function and tissue distribution

D. Power, P. Deen, J. Cardoso, 2004, Journal of Experimental Biology.

Structural analysis of the entire proopiomelanocortin gene of Xenopus laevis.

E. Roubos, P. Deen, M. Bussemakers, 1991, European journal of biochemistry.

Comparative structural analysis of the transcriptionally active proopiomelanocortin genes A and B of Xenopus laevis.

E. Roubos, P. Deen, M. Bussemakers, 1992, Molecular biology and evolution.

Single-tubule RNA-Seq uncovers signaling mechanisms that defend against hyponatremia in SIADH.

Jae Wook Lee, P. Deen, M. Knepper, 2018, Kidney international.

Identification of Acer2 as a First Susceptibility Gene for Lithium-Induced Nephrogenic Diabetes Insipidus in Mice.

R. Korstanje, M. Wiles, P. Deen, 2019, Journal of the American Society of Nephrology : JASN.

Autosomal recessive mental retardation, deafness, ankylosis, and mild hypophosphatemia associated with a novel ANKH mutation in a consanguineous family.

Jefte M. Drijvers, C. Cremers, H. Kremer, 2011, The Journal of clinical endocrinology and metabolism.

Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells.

R. Korstanje, U. Engelke, R. Wevers, 2018, American journal of physiology. Renal physiology.

Molecular cloning and expression of a cyclic AMP-activated chloride conductance regulator: a novel ATP-binding cassette transporter.

F. Lang, P. Deen, F. Russel, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Presence of Vi-transposon-like elements in the proopiomelanocortin gene A of Xenopus laevis does not affect gene activity

E. Roubos, P. Deen, G. Martens, 1991, Molecular and General Genetics MGG.

Congenital nephrogenic diabetes insipidus: the current state of affairs

P. Deen, N. Knoers, D. Wesche, 2012, Pediatric Nephrology.

Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla.

J. Wetzels, P. Deen, N. Hadrup, 2013, American journal of physiology. Renal physiology.

Hypotonicity-induced Reduction of Aquaporin-2 Transcription in mpkCCD Cells Is Independent of the Tonicity Responsive Element, Vasopressin, and cAMP*

J. Wetzels, P. Deen, M. Kortenoeven, 2011, The Journal of Biological Chemistry.

Lithium-induced NDI: acetazolamide reduces polyuria but does not improve urine concentrating ability.

J. Wetzels, P. Deen, R. Walker, 2017, American journal of physiology. Renal physiology.

Heteroligomerization of an Aquaporin-2 mutant with wild-type Aquaporin-2 and their misrouting to late endosomes/lysosomes explains dominant nephrogenic diabetes insipidus.

D. Bichet, P. Deen, C. van Os, 2002, Human molecular genetics.

Vasopressin type-2 receptor and aquaporin-2 water channel mutants in nephrogenic diabetes insipidus.

P. Deen, N. Knoers, 1998, The American journal of the medical sciences.

Repulsion between Lys258 and upstream arginines explains the missorting of the AQP2 mutant p.Glu258Lys in nephrogenic diabetes insipidus

G. Tamma, P. Deen, E. Kamsteeg, 2009, Human mutation.

LIP5 interacts with aquaporin 2 and facilitates its lysosomal degradation.

H. C. Stronks, B. W. van Balkom, G. Hendriks, 2009, Journal of the American Society of Nephrology : JASN.

Mouse models for congenital nephrogenic diabetes insipidus: what can we learn from them?

P. Deen, 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Lack of arginine vasopressin-induced phosphorylation of aquaporin-2 mutant AQP2-R254L explains dominant nephrogenic diabetes insipidus.

P. Deen, P. van der Sluijs, E. Kamsteeg, 2005, Journal of the American Society of Nephrology : JASN.

Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats

A. Cools, A. Blokland, S. Korte, 2008, Psychopharmacology.

SLC29A3 gene is mutated in pigmented hypertrichosis with insulin-dependent diabetes mellitus syndrome and interacts with the insulin signaling pathway.

R. Hennekam, T. Roscioli, R. Lindeman, 2009, Human molecular genetics.

NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation

V. Wong, I. Stagljar, P. Deen, 2017, PloS one.

NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation

V. Wong, I. Stagljar, P. Deen, 2017, PloS one.

Aquaporin-2 water channel mutations causing nephrogenic diabetes insipidus.

P. Deen, C. van Os, 1998, Proceedings of the Association of American Physicians.

How the COVID-19 pandemic highlights the necessity of animal research

L. Joosten, M. Netea, K. van Oers, 2020, Current Biology.

How the COVID-19 pandemic highlights the necessity of animal research

L. Joosten, M. Netea, K. van Oers, 2020, Current Biology.

Water in health and disease: new aspects of disturbances in water metabolism.

J. Wetzels, P. Deen, H. P. Peters, 2007, The Netherlands journal of medicine.

Lithium causes G2 arrest of renal principal cells.

P. Deen, R. Giles, R. Baumgarten, 2014, Journal of the American Society of Nephrology : JASN.

Blockade of dopamine, but not noradrenaline, transporters produces hyperthermia in rats that lack serotonin transporters.

A. Cools, P. Deen, B. Ellenbroek, 2010, European journal of pharmacology.

Biochemical characterization of bona fide polycystin-1 in vitro and in vivo.

P. Courtoy, G. Germino, L. Onuchic, 2001, American journal of kidney diseases : the official journal of the National Kidney Foundation.

sialic acid transport − Intellectual disability and bleeding diathesis due to deficient CMP

R. Wevers, P. Deen, A. Brouwer, 2013 .

MicroRNA-132 regulates salt-dependent steady-state renin levels in mice

T. Rabelink, P. Deen, A. V. van Zonneveld, 2020, Communications Biology.

MicroRNA-132 regulates salt-dependent steady-state renin levels in mice

T. Rabelink, P. Deen, A. V. van Zonneveld, 2020, Communications Biology.

Aquaporins: water selective channels in biological membranes. Molecular structure and tissue distribution.

P. Deen, C. van Os, J. Dempster, 1994, Biochimica et biophysica acta.

Intellectual disability and bleeding diathesis due to deficient CMP–sialic acid transport

R. Wevers, P. Deen, E. Morava, 2013, Neurology.

Aquaporins and ion conductance.

A S Verkman, P. Deen, C. van Os, 1997, Science.

Novel mutation in the AVPR2 gene in a Danish male with nephrogenic diabetes insipidus caused by ER retention and subsequent lysosomal degradation of the mutant receptor

G. Milligan, D. Bichet, P. Deen, 2011, NDT plus.

A 76-bp deletion in the Mip gene causes autosomal dominant cataract in Hfi mice.

P. Deen, D. Stambolian, W. Skach, 2001, Genomics.