M. Tominaga

发表

OPC-41061, a highly potent human vasopressin V2-receptor antagonist: pharmacological profile and aquaretic effect by single and multiple oral dosing in rats.

T Yamashita, G. Tsujimoto, Y. Yamamura, 1998, The Journal of pharmacology and experimental therapeutics.

[Effects of pranidipine (OPC-13340), a novel 1,4-dihydropyridine derivative Ca-antagonist, on isolated porcine coronary contraction and acute myocardial ischemia in the pig].

M. Tominaga, T. Mori, Y. Yabuuchi, 1994, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Orally active, nonpeptide vasopressin V2 receptor antagonists: a novel series of 1-[4-(benzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepines and related compounds.

Y. Yamamura, S. Nakamura, H. Ogawa, 1996, Journal of medicinal chemistry.

Cardiovascular effects of the combination of OPC-18790 and dopamine in halothane-anesthetized dogs.

H. Fujiki, S. Itoh, M. Tominaga, 1995, Japanese journal of pharmacology.

Characterization of a novel nonpeptide vasopressin V2‐agonist, OPC‐51803, in cells transfected human vasopressin receptor subtypes

G. Tsujimoto, Y. Yamamura, Shigeki Nakamura, 2000, British journal of pharmacology.

Antidiuretic effects of a nonpeptide vasopressin V(2)-receptor agonist, OPC-51803, administered orally to rats.

Y. Yamamura, S. Nakamura, T. Hirano, 2000, The Journal of pharmacology and experimental therapeutics.

Differential effects of OPC‐18790, amrinone and dobutamine on cardiac function and energy metabolism in the guinea‐pig isolated ischaemic heart

Toyoki Mori, S. Itoh, M. Tominaga, 1995, British journal of pharmacology.

Effects of OPC-18790, a new positive inotropic agent, on energetics in the ischaemic canine heart: a 31P-MRS study.

H. Fujiki, S. Itoh, M. Tominaga, 1995, Cardiovascular research.

Mechanisms of action of OPC-28326, a selective hindlimb vasodilator.

H. Fujiki, M. Tominaga, T. Mori, 1999, The Journal of pharmacology and experimental therapeutics.

Studies on positive inotropic agents. I. Synthesis of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone and related compounds.

H. Ogawa, M. Tominaga, Y. Yabuuchi, 1984, Chemical & pharmaceutical bulletin.

Novel thiazole derivatives as inhibitors of superoxide production by human neutrophils: synthesis and structure-activity relationships.

M. Tominaga, T. Mori, Y. Yabuuchi, 1995, Journal of medicinal chemistry.

7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoyl-amino)benzoyl ]-2,3,4,5-tetrahydro-1H-1-benzazepine (OPC-41061): a potent, orally active nonpeptide arginine vasopressin V2 receptor antagonist.

Y. Yamamura, S. Nakamura, T. Onogawa, 1999, Bioorganic & medicinal chemistry.

OPC-21268, an orally effective, nonpeptide vasopressin V1 receptor antagonist.

Y. Yamamura, Shigeki Nakamura, Toyoki Mori, 1991, Science.

OPC-21268 antagonizes arginine vasopressin-induced vasoconstrictor response in the spinally-anesthetized dog.

Y. Yamamura, S. Nakamura, T. Onogawa, 1995, Japanese journal of pharmacology.

Novel positive inotropic agents: synthesis and biological activities of 6-(3-amino-2-hydroxypropoxy)-2(1H)-quinolinone derivatives.

M. Tominaga, T. Mori, Y. Yabuuchi, 1992, Journal of medicinal chemistry.

Characterization of a novel aquaretic agent, OPC‐31260, as an orally effective, nonpeptide vasopressin V2 receptor antagonist

Yoshitaka Yamamura, Y. Yamamura, Shigeki Nakamura, 1992, British journal of pharmacology.

OPC-21268, a vasopressin V1 antagonist, produces hypotension in spontaneously hypertensive rats.

Y. Yamamura, S. Nakamura, T. Onogawa, 1994, Hypertension.

Studies on positive inotropic agents. V. Synthesis of 1-heteroaroylpiperazine derivatives.

H. Ogawa, K. Kondo, M. Tominaga, 1988, Chemical & pharmaceutical bulletin.

Novel design of nonpeptide AVP V(2) receptor agonists: structural requirements for an agonist having 1-(4-aminobenzoyl)-2,3,4, 5-tetrahydro-1H-1-benzazepine as a template.

A. Itai, Y. Yamamura, S. Nakamura, 2000, Journal of medicinal chemistry.

Studies on antibacterial agents. III. Synthesis and antibacterial activities of substituted 1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acids.

M. Tominaga, H. Miyamoto, K. Nakagawa, 1990, Chemical & pharmaceutical bulletin.

Studies on antibacterial agents. II. Synthesis and antibacterial activities of substituted 1,2-dihydro-6-oxo-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acids.

H. Ishikawa, M. Tominaga, H. Miyamoto, 1990, Chemical & pharmaceutical bulletin.

Characterization of orally active nonpeptide vasopressin V(2) receptor agonist. Synthesis and biological evaluation of both the (5R)- and (5S)-enantioisomers of 2-[1-(2-Chloro-4-pyrrolidin-1-yl-benzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin- 5-yl]-N-isopropylacetamide.

Y. Yamamura, Shigeki Nakamura, Toyoki Mori, 2002, Journal of medicinal chemistry.

STEREOSELECTIVE SYNTHESIS OF THE PINK BOLLWORM SEX PHEROMONE, (Z,Z)-7,11-HEXADECADIENYL ACETATE AND ITS (Z,E)-ISOMER

K. Mori, M. Tominaga, M. Matsui, 1975 .

Studies on Positive Inotropic Agents. Part 5. Synthesis of 1-Heteroaroylpiperazine Derivatives.

H. Ogawa, K. Kondo, M. Tominaga, 1989 .

A MILD TRANSESTERIFICATION METHOD

K. Mori, M. Tominaga, M. Matsui, 1973 .

Syntheses and β-Adrenergic Blocking Activities of Carbostyril Derivatives

Kozo Watanabe, M. Tominaga, K. Nakagawa, 1981 .

Derivatives of 3,4-dihydrocarbostyril as beta-adrenergic blocking agents.

M. Tominaga, Y. Yabuuchi, H. Mori, 1974, Journal of medicinal chemistry.

Cardiovascular actions of OPC-18790: A novel positive inotropic agent with little chronotropic action

H. Fujiki, Toyoki Mori, M. Tominaga, 2005, Heart and Vessels.

DERIVATIVES OF 3,4-DIHYDROCARBOSTYRIL AS BETA-ADRENERGIC BLOCKING AGENTS

M. Tominaga, Y. Yabuuchi, H. Mori, 1974 .

OPC-18790, a novel positive inotropic agent, has both arterial and venous vascular dilating actions in the dog.

H. Fujiki, M. Tominaga, T. Mori, 1996, European journal of pharmacology.

Effect of the Molecular Chain Length on Biological Activity of Juvenile Hormone Analogs

K. Kiguchi, K. Mori, M. Tominaga, 1975 .

A Simple Synthesis of Methyl 10,11-Oxido-3,7,11-trimethyldodeca-2,4,6-trienoate, an Analog of the Cecropia Juvenile Hormone

K. Mori, M. Tominaga, M. Matsui, 1974 .

Synthesis of 5,8-dihydroxy-3,4-dihydrocarbostyril.

M. Tominaga, K. Nakagawa, E. Yo, 1981 .

Venodilatory effect of pranidipine, a calcium channel blocker, monitored with perfluorocarbon in vivo (19)F-NMR spectroscopy.

M. Tominaga, Y. Yabuuchi, T. Sogabe, 2000, Magnetic resonance imaging.

Effects of vasodilators on the signal intensity of perfluorocarbon monitored by in vivo 19F-NMR spectroscopy.

M. Tominaga, Y. Yabuuchi, T. Sogabe, 1997, Magnetic resonance imaging.

Positive inotropic and chronotropic effects of toborinone and its electrophysiological properties in the isolated hearts of rabbits and guinea-pigs.

H. Fujiki, M. Tominaga, T. Mori, 1996, Arzneimittel-Forschung.

Orally active, nonpeptide vasopressin V1 antagonists. A novel series of 1-(1-substituted 4-piperidyl)-3,4-dihdyro-2(1H)-quinolinone.

Y. Yamamura, H. Ogawa, H. Yamashita, 1993, Journal of Medicinal Chemistry.