Andreas Krämer

发表

Optimization of pyrazolo[1,5-a]pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor

S. Knapp, Andreas Krämer, C. Kurz, 2020, bioRxiv.

A chemical toolbox for the study of bromodomains and epigenetic signaling

Shili Duan, Mathieu Lupien, Stefan Knapp, 2018, bioRxiv.

Substrate specificity and function of acetylpolyamine amidohydrolases from Pseudomonas aeruginosa

Andreas Krämer, F. Meyer‐Almes, J. Overhage, 2016, BMC Biochemistry.

A fluorescence lifetime-based binding assay for acetylpolyamine amidohydrolases from Pseudomonas aeruginosa using a [1,3]dioxolo[4,5-f][1,3]benzodioxole (DBD) ligand probe

Andreas Krämer, Robert Wawrzinek, F. Meyer‐Almes, 2014, Analytical and Bioanalytical Chemistry.

Involvement of a Novel Class C Beta-Lactamase in the Transglutaminase Mediated Cross-Linking Cascade of Streptomyces mobaraensis DSM 40847

Andreas Krämer, H. Fuchsbauer, Sabrina Fröls, 2016, PloS one.

Development of a potent and selective chemical probe for the pleiotropic kinase CK2.

S. Knapp, S. Müller, D. Drewry, 2020, Cell chemical biology.

Selective targeting of the αC and DFG-out pocket in p38 MAPK.

S. Knapp, S. Laufer, A. Joerger, 2020, European journal of medicinal chemistry.

The thermodynamic signature of ligand binding to histone deacetylase-like amidohydrolases is most sensitive to the flexibility in the L2-loop lining the active site pocket.

Andreas Krämer, F. Meyer‐Almes, C. Meyners, 2017, Biochimica et biophysica acta. General subjects.

Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-a]pyrimidine-Based Macrocycles.

S. Knapp, S. Müller, Andreas Krämer, 2022, Journal of medicinal chemistry.

Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors.

Andreas Krämer, M. Fuchter, F. Meyer‐Almes, 2017, ACS infectious diseases.

Perfluorinated hydroxamic acids are potent and selective inhibitors of HDAC-like enzymes from Pseudomonas aeruginosa.

Andreas Krämer, F. Meyer‐Almes, C. Meyners, 2017, Bioorganic & medicinal chemistry letters.

Cascade Synthesis of Kinase-Privileged 3-Aminoindazoles via Intramolecular N-N Bond Formation.

Wei Zhu, S. Knapp, E. Proschak, 2022, The Journal of organic chemistry.

IPP/CNRS-A017: A chemical probe for human dihydroorotate dehydrogenase (hDHODH)

S. Knapp, S. Müller, H. Farin, 2022, Current Research in Chemical Biology.

Optimization of pyrazolo[1,5-a]pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor.

S. Knapp, Andreas Krämer, C. Kurz, 2020, European journal of medicinal chemistry.

Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators

S. Knapp, Andreas Krämer, S. Butterworth, 2022, Acta pharmaceutica Sinica. B.

Covalent inhibition of histone deacetylase 8 by 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine.

Andreas Krämer, M. Jung, G. Brenner-Weiss, 2019, Biochimica et biophysica acta. General subjects.

Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.

S. Knapp, P. Jänne, M. Eck, 2022, Journal of medicinal chemistry.

Function, Structure and Topology of Protein Kinases

S. Knapp, Andreas Krämer, S. Röhm, 2020, Proteinkinase Inhibitors.

Development of a chemical probe against NUDT15

S. Knapp, T. Helleday, T. Schaller, 2020, Nature Chemical Biology.

Discovery of 3-Amino-1H-pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family

S. Knapp, S. Müller, M. Schubert-Zsilavecz, 2022, International journal of molecular sciences.

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

S. Knapp, T. Helleday, Neeraj Garg, 2022, Nature Cancer.

MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core.

S. Knapp, S. Müller, Andreas Krämer, 2022, Journal of medicinal chemistry.

Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells

S. Knapp, R. Walker-Gray, Andreas Krämer, 2022, International journal of molecular sciences.

Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore.

Tammy M. Havener, S. Knapp, D. Drewry, 2022, European journal of medicinal chemistry.

Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis.

S. Knapp, A. Joerger, Andreas Krämer, 2020, Journal of medicinal chemistry.

Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm

A. Fersht, A. Joerger, G. Settanni, 2020, ACS chemical biology.

Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders.

B. Kuster, S. Knapp, C. Sotriffer, 2021, Journal of medicinal chemistry.

Design, Synthesis and Evaluation of WD-repeat containing protein 5 (WDR5) degraders

B. Kuster, S. Knapp, C. Sotriffer, 2021, bioRxiv.

Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum

S. Knapp, V. Lauschke, S. Müller, 2023, ACS chemical biology.

Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization

K. Saxena, S. Knapp, Andreas Krämer, 2023, bioRxiv.

Crystal Structure of a Histone Deacetylase Homologue from Pseudomonas aeruginosa.

Andreas Krämer, F. Meyer‐Almes, T. Wagner, 2016, Biochemistry.

Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily

S. Knapp, A. Poso, A. Joerger, 2023, bioRxiv.

A chemical toolbox for the study of bromodomains and epigenetic signaling

S. Knapp, O. Fedorov, M. Lupien, 2019, Nature Communications.

Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2.

Tammy M. Havener, D. Drewry, C. Wells, 2023, ACS medicinal chemistry letters.

Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B.

L. Meijer, S. Knapp, Andreas Krämer, 2023, Journal of medicinal chemistry.

Development of Selective Pyrido[2,3-d]pyrimidin-7(8H)-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors.

A. Joerger, T. Kronenberger, Andreas Krämer, 2024, Journal of medicinal chemistry.