P. Cullen

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To degrade or not to degrade: mechanisms and significance of endocytic recycling

P. Cullen, Florian Steinberg, 2018, Nature Reviews Molecular Cell Biology.

The frequencies of calcium oscillations are optimized for efficient calcium-mediated activation of Ras and the ERK/MAPK cascade.

P. Cullen, S. Kupzig, S. Walker, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Endosomal sorting and signalling: an emerging role for sorting nexins

P. Cullen, 2008, Nature Reviews Molecular Cell Biology.

CAPRI regulates Ca2+-dependent inactivation of the Ras-MAPK pathway

P. Cullen, S. Kupzig, P. J. Lockyer, 2001, Current Biology.

Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1

Peter J. Cullen, Peter J. Lockyer, A. Pellicer, 2003, Nature.

Sorting Nexin-1 Mediates Tubular Endosome-to-TGN Transport through Coincidence Sensing of High- Curvature Membranes and 3-Phosphoinositides

Judith Klumperman, Peter J. Cullen, Harvey T. McMahon, 2004, Current Biology.

The Retromer Coat Complex Coordinates Endosomal Sorting and Dynein-Mediated Transport, with Carrier Recognition by the trans-Golgi Network

H. Korswagen, T. Wassmer, P. Verkade, 2009, Developmental cell.

Electroporation can cause artefacts due to solubilization of cations from the electrode plates. Aluminum ions enhance conversion of inositol 1,3,4,5-tetrakisphosphate into inositol 1,4,5-trisphosphate in electroporated L1210 cells.

P. Cullen, A. Dawson, R. Irvine, 1991, The Biochemical journal.

Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing.

G. Rutter, P. Cullen, Q. Qian, 2004, The Biochemical journal.

Integration of calcium and RAS signalling

Peter J. Cullen, Peter J. Lockyer, P. Cullen, 2002, Nature Reviews Molecular Cell Biology.

Will the real IP4 receptor please stand up?

P. Cullen, R. Irvine, 1993, Current Biology.

Several proteins have been described that bind IP, with a variety of different potencies and specificities. Amidst this confusion, is there consistent evidence for a 'true' IP, receptor?

P. Cullen, R. Irvine, Intracellular Signalling, 1993 .

The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport

Jeremy G. Carlton, T. Wassmer, P. Cullen, 2006, Journal of Cell Science.

Membrane association, localization and topology of rat inositol 1,4,5-trisphosphate 3-kinase B: implications for membrane traffic and Ca2+ homoeostasis.

S. High, P. Cullen, C. D’Santos, 1997, The Biochemical journal.

Modulation of Ins(2,4,5)P3-stimulated Ca2+ mobilization by ins(1,3,4, 5)P4: enhancement by activated G-proteins, and evidence for the involvement of a GAP1 protein, a putative Ins(1,3,4,5)P4 receptor.

P. Cullen, A. Dawson, R. Irvine, 1998, The Biochemical journal.

SNX1 Defines an Early Endosomal Recycling Exit for Sortilin and Mannose 6‐Phosphate Receptors

H. Geuze, P. Cullen, W. Geerts, 2008, Traffic.

Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells

S. Schurmans, P. Cullen, O. Leo, 2007, Proceedings of the National Academy of Sciences.

Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation

P. Cullen, Florian Steinberg, A. Whone, 2014, Current Biology.

Phosphatidylinositol 3-kinase-dependent translocation of phospholipase Cgamma2 in mouse megakaryocytes is independent of Bruton tyrosine kinase translocation.

S. Watson, P. Cullen, W. Siess, 2001, Blood.

Regulation of P2Y1 Receptor Traffic by Sorting Nexin 1 is Retromer Independent

S. Mundell, P. Cullen, E. Kelly, 2010, Traffic.

Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1.

J. Tavaré, P. Cullen, K. Venkateswarlu, 1999, The Biochemical journal.

GAP1 Family Members Constitute Bifunctional Ras and Rap GTPase-activating Proteins*

A. Wittinghofer, O. Daumke, P. Cullen, 2006, Journal of Biological Chemistry.

Analyzing the Role of the Putative Inositol 1,3,4,5-Tetrakisphosphate Receptor GAP1IP4BP in Intracellular Ca2+ Homeostasis*

P. Cullen, D. Zharhary, S. Kupzig, 2002, The Journal of Biological Chemistry.

Neuropilin-1 is a host factor for SARS-CoV-2 infection

D. Matthews, Y. Yamauchi, P. Horváth, 2020, Science.

A global analysis of SNX27–retromer assembly and cargo specificity reveals a function in glucose and metal ion transport

J. Tavaré, P. Cullen, Florian Steinberg, 2013, Nature Cell Biology.

Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2

Z. Bashir, J. Henley, K. Wilkinson, 2020, bioRxiv.

Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins

G. Bashaw, P. Cullen, Florian Steinberg, 2019, Nature Cell Biology.

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3)-binder Rasa3 Regulates Phosphoinositide 3-kinase (PI 3-kinase)-dependent Integrin IIb3 Outside-in Signaling. (5),

David S. Paul, P. Cullen, I. Hers, 2017 .

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling*

David S. Paul, P. Cullen, I. Hers, 2016, The Journal of Biological Chemistry.

The Ability of GAP1IP4BP To Function as a Rap1 GTPase-Activating Protein (GAP) Requires Its Ras GAP-Related Domain and an Arginine Finger Rather than an Asparagine Thumb

R. Sessions, P. Cullen, S. Kupzig, 2009, Molecular and Cellular Biology.

Identification of the Ras GTPase-activating protein GAP1m as a phosphatidylinositol-3,4,5-trisphosphate-binding protein in vivo

J. Downward, P. Cullen, K. Venkateswarlu, 1999, Current Biology.

Structural and Functional Analysis of the Putative Inositol 1,3,4,5-Tetrakisphosphate Receptors GAP1IP4BPand GAP1m

P. Cullen, P. J. Lockyer, J. S. Reynolds, 1998 .

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Y. Yamauchi, P. Cullen, T. Teesalu, 2022, bioRxiv.

Casein Kinase I Associates with Members of the Centaurin-α Family of Phosphatidylinositol 3,4,5-Trisphosphate-binding Proteins*

S. Howell, A. Aitken, P. Roach, 2001, The Journal of Biological Chemistry.

The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport.

T. Wassmer, M. Matsuda, P. Cullen, 2008, Molecular biology of the cell.

Multi-omic approach characterises the neuroprotective role of retromer in regulating lysosomal health

D. Cacchiarelli, A. Ballabio, P. Cullen, 2022, bioRxiv.

Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50

B. Diedrich, J. Dengjel, P. Cullen, 2017, Journal of Cell Science.

Atypical parkinsonism–associated retromer mutant alters endosomal sorting of specific cargo proteins

K. Wilkinson, P. Cullen, K. Heesom, 2016, The Journal of cell biology.

Retromer/WASH dependent sorting of nutrient transporters requires a multivalent interaction network with

B. Diedrich, J. Dengjel, P. Cullen, 2016 .

A defect in the retromer accessory protein, SNX27, manifests by infantile myoclonic epilepsy and neurodegeneration

P. Cullen, S. Edvardson, O. Elpeleg, 2015, neurogenetics.

Identification of molecular heterogeneity in SNX27–retromer-mediated endosome-to-plasma-membrane recycling

P. Cullen, Florian Steinberg, K. Heesom, 2014, Journal of Cell Science.

Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation

P. Cullen, Florian Steinberg, A. Whone, 2014, Current Biology.

Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation

P. Cullen, Florian Steinberg, A. Whone, 2014, Current Biology.

Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain.

J. Tavaré, P. Cullen, F. Gunn-Moore, 1998, The Biochemical journal.

Mammalian copper homeostasis requires retromer-dependent recycling of the high-affinity copper transporter 1

P. Cullen, R. Curnock, Rachel Curnock, 2020, Journal of Cell Science.

Acute inactivation of retromer and ESCPE-1 leads to time-resolved defects in endosomal cargo sorting

P. Cullen, Ashley J. Evans, James L. Daly, 2020, Journal of Cell Science.

Mammalian copper homeostasis requires retromer-dependent recycling of the high-affinity copper transporter 1 (CTR1/SLC31A1)

P. Cullen, R. Curnock, 2020, bioRxiv.

Acute perturbation of retromer and ESCPE-1 leads to functionally distinct and temporally resolved defects in endosomal cargo sorting

P. Cullen, Ashley J. Evans, James L. Daly, 2019, bioRxiv.

TFEB controls retromer expression in response to nutrient availability

A. Ballabio, P. Cullen, Alessia Calcagnì, 2019, The Journal of cell biology.

Actin-dependent endosomal receptor recycling.

P. Cullen, Boris Simonetti, 2019, Current opinion in cell biology.

Endosomal Sorting: Architecture of the Retromer Coat

P. Cullen, Boris Simonetti, 2018, Current Biology.

Membrane-associated cargo recycling by tubule-based endosomal sorting.

P. Cullen, Jan R. T. van Weering, 2014, Seminars in cell & developmental biology.

SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways

P. Cullen, Florian Steinberg, K. Heesom, 2012, The Journal of cell biology.

Sorting nexins

P. Cullen, Jez G. Carlton, 2005, Current Biology.

Sorting nexin-1 defines an early phase of Salmonella-containing vacuole-remodeling during Salmonella infection

Philip A. Ewels, P. Cullen, M. Jepson, 2008, Journal of Cell Science.

Molecular Cloning and Functional Characterization of a Human Homologue of Centaurin-α

P. Cullen, K. Venkateswarlu, 1999 .

SNX–BAR‐Mediated Endosome Tubulation is Co‐ordinated with Endosome Maturation

P. Verkade, P. Cullen, Jan R. T. van Weering, 2012, Traffic.

Clathrin is not required for SNX-BAR-retromer-mediated carrier formation

P. Cullen, Ian J. McGough, 2013, Journal of Cell Science.

SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment

T. Wassmer, P. Cullen, D. Stephens, 2007, Nature Cell Biology.

Membrane Curvature: The Power of Bananas, Zeppelins and Boomerangs

P. Cullen, Giles O. C. Cory, 2007, Current Biology.

EGF-and NGF-stimulated translocation of cytohesin-1 to the plasma membrane of PC12 cells requires PI 3-kinase activation and a functional cytohesin-1 PH domain.

J. Tavaré, P. Cullen, F. Gunn-Moore, 1999, Journal of cell science.

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

P. Cullen, M. Hanley, A. Dawson, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage

S. Christensen, P. Cullen, M. Hanley, 2005, Agents and Actions.

Heparin inhibits the inositol 1,4,5‐trisphosphate‐induced Ca2+ release from rat liver microsomes

P. Cullen, A. Dawson, J. G. Comerford, 1988, FEBS letters.

University ’ s repository of research publications and other research outputs CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca ¡ sup ¿ 2 +

M. Bootman, H. Roderick, P. Cullen, 2013 .

Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins

Michael D Healy, P. Cullen, B. Collins, 2021, bioRxiv.

Engineering the Phosphoinositide-binding Profile of a Class I Pleckstrin Homology Domain*

P. Cullen, G. Cozier, D. Bouyoucef, 2003, Journal of Biological Chemistry.

Effects of elevated expression of inositol 1,4,5-trisphosphate 3-kinase B on Ca2+ homoeostasis in HeLa cells.

P. Cullen, G. Banting, T. Millard, 2000, The Biochemical journal.

Signalling via ADP-ribosylation factor 6 lies downstream of phosphatidylinositide 3-kinase.

P. Cullen, K. Venkateswarlu, 2000, The Biochemical journal.

The Ras binary switch: an ideal processor for decoding complex Ca2+ signals?

P. Cullen, S. Walker, P. J. Lockyer, 2003, Biochemical Society transactions.

The retromer complex.

P. Cullen, Naomi Attar, 2010, Advances in enzyme regulation.

Signaling: retromer arrests receptor on the run.

P. Cullen, Jan R. T. van Weering, 2011, Nature chemical biology.

Modular phosphoinositide-binding domains – their role in signalling and membrane trafficking

P. Cullen, G. Banting, G. Cozier, 2001, Current Biology.

Parkinson’s disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes

Wenzhang Wang, Xiongwei Zhu, C. Hoppel, 2015, Nature Medicine.

Decoding complex Ca2+ signals through the modulation of Ras signaling.

P. Cullen, 2006, Current opinion in cell biology.

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1.

A. Pellicer, Theresa M. Grana, A. Cox, 2003, Nature.

Specific binding sites for inositol 1,3,4,5-tetrakisphosphate are located predominantly in the plasma membranes of human platelets.

V. Kakkar, P. Cullen, R. Irvine, 1994, The Biochemical journal.

Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate.

P. Cullen, A. Dawson, B. Drøbak, 1989, The Biochemical journal.

Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage

S. Christensen, P. Cullen, M. Hanley, 1989, Agents and Actions.

Retromer: a master conductor of endosome sorting.

C. Burd, P. Cullen, 2014, Cold Spring Harbor perspectives in biology.

Sorting nexins provide diversity for retromer-dependent trafficking events

H. Korswagen, P. Cullen, 2011, Nature Cell Biology.

Inositol 1,3,4,5-tetrakisphosphate binding sites in neuronal and non-neuronal tissues. Properties, comparisons and potential physiological significance.

P. Cullen, R. Irvine, 1992, The Biochemical journal.

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling

R. Sessions, D. Pim, L. Banks, 2017, Nature Cell Biology.

Tissue-specific expression and endogenous subcellular distribution of the inositol 1,3,4,5-tetrakisphosphate-binding proteins GAP1(IP4BP) and GAP1(m).

J. Parys, P. Cullen, P. J. Lockyer, 1999, Biochemical and biophysical research communications.

Epigenetic silencing of a Ca2+-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers

Zhong-ying Shen, E. Li, Q. Tao, 2007, Proceedings of the National Academy of Sciences.

The Open University ’ s repository of research publications and other research outputs CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca

Yanfeng Dai, Peter J. Cullen, H. Llewelyn Roderick, 2016 .

The GAP1 family of GTPase-activating proteins: spatial and temporal regulators of small GTPase signalling.

P. Cullen, S. Yarwood, S. Kupzig, 2006, Biochemical Society transactions.

Studying the spatial and temporal regulation of Ras GTPase-activating proteins.

P. Cullen, G. Cozier, S. Kupzig, 2006, Methods in Enzymology.

CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+

Peter J. Cullen, H. Llewelyn Roderick, Martin D. Bootman, 2005, The Journal of cell biology.

Identification of a Ras GTPase‐activating protein regulated by receptor‐mediated Ca2+ oscillations

Guy A Rutter, Takashi Tsuboi, G. Rutter, 2004, The EMBO journal.

Control of Ras cycling by Ca2+

P. Cullen, S. Walker, P. J. Lockyer, 2003, FEBS letters.

GAP1IP4BP contains a novel group I pleckstrin homology domain that directs constitutive plasma membrane association.

P. Cullen, G. Banting, G. Cozier, 2000, The Journal of biological chemistry.

Bridging the GAP in inositol 1,3,4,5-tetrakisphosphate signalling.

P. Cullen, 1998, Biochimica et biophysica acta.

Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting

P. J. Cullen, P. Cullen, B. Potter, 1997, Current Biology.

Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase

J. Tavaré, P. Cullen, K. Venkateswarlu, 1998, Current Biology.

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion

H. Korswagen, P. Cullen, M. Betist, 2018, Nature Communications.

A SNX3-dependent Retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion

Roy G van Heesbeen, H. Korswagen, P. Cullen, 2011, Nature Cell Biology.

Identification of a specific lns(l,3,4,5)P4-binding protein as a member of the GAP1 family

Peter J. Cullen, J. Justin Hsuan, J. Hsuan, 1995, Nature.

Retromer and sorting nexins in endosomal sorting.

P. Cullen, M. Gallon, 2015, Biochemical Society transactions.

Phosphoinositides in the mammalian endo-lysosomal network.

Jeremy G. Carlton, P. Cullen, J. Carlton, 2012, Sub-cellular biochemistry.

Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR

P. Cullen, K. Heesom, Boris Simonetti, 2017, The Journal of cell biology.

A defect in the retromer accessory protein, SNX27, manifests by infantile myoclonic epilepsy and neurodegeneration

P. Cullen, S. Edvardson, O. Elpeleg, 2015, neurogenetics.

A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer

R. Teasdale, R. Sessions, C. Mas, 2014, Proceedings of the National Academy of Sciences.

Membrane targeting by pleckstrin homology domains.

P. Cullen, G. Cozier, D. Bouyoucef, 2004, Current topics in microbiology and immunology.

Ras effectors: Buying shares in Ras plc

P. Cullen, 2001, Current Biology.

Intracellular membrane traffic at high resolution.

T. Sharp, P. Verkade, P. Cullen, 2010, Methods in cell biology.

Sorting Nexins – Unifying Trends and New Perspectives

P. Cullen, Jez G. Carlton, M. Bujny, 2005, Traffic.

Endosomal Retrieval of Cargo: Retromer Is Not Alone.

P. Cullen, Kerrie E. McNally, 2018, Trends in cell biology.

Microtubule motors mediate endosomal sorting by maintaining functional domain organization

P. Cullen, D. Stephens, Anna K. Townley, 2013, Journal of Cell Science.

Confocal imaging of the subcellular distribution of phosphatidylinositol 3,4,5-trisphosphate in insulin- and PDGF-stimulated 3T3-L1 adipocytes.

J. Tavaré, P. Cullen, L. Fletcher, 1999, The Biochemical journal.

Structure of the Commander endosomal trafficking complex linked to X-linked intellectual disability/Ritscher-Schinzel syndrome

Michael D Healy, E. Derivery, P. Cullen, 2023, bioRxiv.

CHC22 clathrin membrane recruitment uses SNX5 in bipartite interaction with secretory tether p115

P. Cullen, Joshua Greig, Boris Simonetti, 2023, bioRxiv.

Intracellular signalling: Inositol phosphates – whither bound?

P. Cullen, R. Irvine, 1996, Current Biology.

SNX-BAR proteins in phosphoinositide-mediated, tubular-based endosomal sorting.

P. Verkade, P. Cullen, Jan R. T. van Weering, 2010, Seminars in cell & developmental biology.

Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions

H. Strutt, D. Strutt, P. Cullen, 2019, Current Biology.

A global analysis of SNX27–retromer assembly and cargo specicity reveals a function in glucose and metal ion transport

J. Tavaré, P. Cullen, Florian Steinberg, 2013, Nature Cell Biology.

Retromer arrests receptor on the run

P. Cullen, Jan R. T. Weering, 2014 .

A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer

T. Wassmer, P. Cullen, M. Bujny, 2006, Journal of Cell Science.

Coincidence detection in phosphoinositide signaling.

P. Cullen, Jez G. Carlton, Jez G Carlton, 2005, Trends in cell biology.

SNX27–Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recycling

P. Cullen, B. Collins, T. Williams, 2022, PLoS biology.

Mechanistic basis for SNX27-Retromer coupling to ESCPE-1 in promoting endosomal cargo recycling

P. Cullen, B. Collins, T. Williams, 2021, bioRxiv.

Sorting nexin-21 is a scaffold for the endosomal recruitment of huntingtin

P. Cullen, K. Heesom, Chris M. Danson, 2018, Journal of Cell Science.

Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport

B. Peter, P. Cullen, J. Klumperman, 2005, Journal of Cell Science.

Specificity of the purified inositol (1,3,4,5) tetrakisphosphate‐binding protein from porcine platelets

Young‐Tae Chang, P. Cullen, A. Dawson, 1995, FEBS letters.

Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules

J. Hurley, R. Sessions, P. Cullen, 2012, The EMBO journal.

Effects of elevated expression of inositol 1,4,5-trisphosphate 3-kinase B on Ca2+ homoeostasis in HeLa cells.

P. Cullen, G. Banting, T. Millard, 2000, The Biochemical journal.

The Phox Homology (PX) Domain-dependent, 3-Phosphoinositide-mediated Association of Sorting Nexin-1 with an Early Sorting Endosomal Compartment Is Required for Its Ability to Regulate Epidermal Growth Factor Receptor Degradation*

R. Teasdale, P. Cullen, P. Gleeson, 2002, Journal of Biological Chemistry.

Molecular modelling and site-directed mutagenesis of the inositol 1,3,4,5-tetrakisphosphate-binding pleckstrin homology domain from the Ras GTPase-activating protein GAP1IP4BP.

R. Sessions, P. Cullen, G. Cozier, 2000, The Biochemical journal.

Synergistic effects of inositol 1,3,4,5-tetrakisphosphate on inositol 2,4,5-triphosphate-stimulated Ca2+ release do not involve direct interaction of inositol 1,3,4,5-tetrakisphosphate with inositol triphosphate-binding sites.

P. Cullen, A. Dawson, R. Irvine, 1996, The Biochemical journal.

Sorting nexin 5 mediates virus-induced autophagy and immunity

R. Xavier, S. Schmid, Guanghua Xiao, 2020, Nature.

Sorting Nexin 5 Mediates Virus-Induced Autophagy and Immunity

R. Xavier, S. Schmid, Guanghua Xiao, 2020, Nature.

The retromer component sorting nexin-1 is required for efficient retrograde transport of Shiga toxin from early endosome to the trans Golgi network

L. Johannes, P. Cullen, V. Popoff, 2007, Journal of Cell Science.

Structural insights into the architecture and membrane interactions of the conserved COMMD proteins

Michael D Healy, J. Lott, P. Cullen, 2018, eLife.

Membrane targeting: What a difference a G makes

P. Cullen, P. Chardin, 2000, Current Biology.

GFP fusion proteins to study signaling in live cells.

P. Cullen, G. Cozier, S. Walker, 2004, Methods in molecular biology.

To degrade or not to degrade: mechanisms and significance of endocytic recycling

P. Cullen, Florian Steinberg, 2018, Nature Reviews Molecular Cell Biology.

The emerging role of retromer in neuroprotection

P. Cullen, Kirsty J. McMillan, Hendrick C Korswagen, 2017, Current opinion in cell biology.

Purification and characterization of an Ins(1,3,4,5)P4 binding protein from pig platelets: possible identification of a novel non-neuronal Ins(1,3,4,5)P4 receptor.

P. Cullen, A. Dawson, R. Irvine, 1995, The Biochemical journal.

Recent Advances in Retromer Biology

P. Cullen, Ian J. McGough, 2011, Traffic.

Calcium Signalling: The Ups and Downs of Protein Kinase C

P. Cullen, 2003, Current Biology.

Out of the ESCPE room: Emerging roles of endosomal SNX‐BARs in receptor transport and host–pathogen interaction

P. Cullen, James L. Daly, Boris Simonetti, 2023, Traffic.

A heterodimeric SNX4–SNX7 SNX-BAR autophagy complex coordinates ATG9A trafficking for efficient autophagosome assembly

P. Cullen, J. Lane, Naomi Attar, 2020, Journal of Cell Science.

A heterodimeric SNX4–SNX7 SNX-BAR autophagy complex coordinates ATG9A trafficking for efficient autophagosome assembly

P. Cullen, J. Lane, Naomi Attar, 2020, Journal of Cell Science.

Endoplasmic Reticulum-Endosome Contact Sites: Specialized Interfaces for Orchestrating Endosomal Tubule Fission?

P. Cullen, James L. Daly, 2018, Biochemistry.

Phosphoinositides and the regulation of tubular-based endosomal sorting.

P. Cullen, 2011, Biochemical Society transactions.

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome

Michael D Healy, V. J. Planelles-Herrero, E. Derivery, 2023, Cell.

Structural and functional analysis of the putative inositol 1,3,4, 5-tetrakisphosphate receptors GAP1(IP4BP) and GAP1(m).

P. Cullen, P. J. Lockyer, J. S. Reynolds, 1999, Biochemical and Biophysical Research Communications - BBRC.

IP3 3-Kinase Opposes NGF Driven Neurite Outgrowth

Peter J. Cullen, George Banting, P. Cullen, 2012, PloS one.

Retriever , a multiprotein complex for retromer-independent 1 endosomal cargo recycling 2

R. Sessions, D. Pim, L. Banks, 2017 .

Inositol 1,3,4,5-tetrakisphosphate and Ca2+ homoeostasis: the role of GAP1IP4BP.

P. Cullen, A. Dawson, R. Irvine, 1997, Biochemical Society transactions.

Retromer associates with the cytoplasmic amino-terminus of polycystin-2

Jing Zhou, P. Cullen, F. Tilley, 2018, Journal of Cell Science.

SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome

Jeremy G. Carlton, P. Verkade, M. May, 2013, Journal of Cell Science.

Potential regulation of ADP-ribosylation factor 6 signalling by phosphatidylinositol 3,4,5-trisphosphate.

P. Cullen, K. Venkateswarlu, 1999, Biochemical Society transactions.

Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation

P. Cullen, D. Medina, G. Parenti, 2023, Nature communications.

Synergistic control of Ca2+ mobilization in permeabilized mouse L1210 lymphoma cells by inositol 2,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate.

P. Cullen, A. Dawson, R. Irvine, 1990, The Biochemical journal.

Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex

P. Cullen, K. Heesom, Ya Gao, 2024, bioRxiv.

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome

Michael D Healy, V. J. Planelles-Herrero, E. Derivery, 2023, Cell.

A global analysis of SNX27–retromer assembly and cargo specificity reveals a function in glucose and metal ion transport

J. Tavaré, P. Cullen, Florian Steinberg, 2013, Nature Cell Biology.

Five inhibitory receptors display distinct vesicular distributions in T cells

Xiongtao Ruan, R. Murphy, P. Verkade, 2023, bioRxiv.

CHC22 clathrin membrane recruitment uses SNX5 in bipartite interaction with secretory tether p115

P. Cullen, Joshua Greig, Boris Simonetti, 2023, bioRxiv.

Clathrin is not required for SNX-BAR-retromer-mediated carrier formation

P. Cullen, Ian J. McGough, 2013, Journal of Cell Science.

SNX–BAR‐Mediated Endosome Tubulation is Co‐ordinated with Endosome Maturation

P. Verkade, P. Cullen, Jan R. T. van Weering, 2012, Traffic.

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