S. Kitazume

发表

N-glycan and Alzheimer's disease.

Naoyuki Taniguchi, N. Taniguchi, Yasuhiko Kizuka, 2017, Biochimica et biophysica acta. General subjects.

High-Sensitivity and Low-Toxicity Fucose Probe for Glycan Imaging and Biomarker Discovery.

Chi‐Huey Wong, N. Taniguchi, Yasuhiko Kizuka, 2016, Cell chemical biology.

Effect of spermine-derived AGEs on oxidative stress and polyamine metabolism.

Katsunori Tanaka, N. Taniguchi, S. Kitazume, 2017, Organic & biomolecular chemistry.

Molecular insights into beta-galactoside alpha2,6-sialyltransferase secretion in vivo.

A. Kasahara, N. Taniguchi, S. Kitazume, 2009, Glycobiology.

Functional roles of N‐glycans in cell signaling and cell adhesion in cancer

Naoyuki Taniguchi, Eiji Miyoshi, Akio Matsumoto, 2008, Cancer science.

The occurrence of novel 9-O-sulfated N-glycolylneuraminic acid-capped alpha2-->5-Oglycolyl-linked oligo/polyNeu5Gc chains in sea urchin egg cell surface glycoprotein. Identification of a new chain termination signal for polysialyltransferase.

A. Dell, H. Morris, S. Kitazume, 1996, The Journal of biological chemistry.

Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: a previously unrecognized mechanism for acrolein-mediated oxidative stress.

Katsunori Tanaka, N. Taniguchi, S. Kitazume, 2014, Organic & biomolecular chemistry.

Epigenetic Regulation of a Brain-specific Glycosyltransferase N-Acetylglucosaminyltransferase-IX (GnT-IX) by Specific Chromatin Modifiers*

N. Taniguchi, Yasuhiko Kizuka, S. Kitazume, 2014, The Journal of Biological Chemistry.

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase.

S. Kitazume, R. Oka, T. Saido, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1).

S. Kitazume, N. Dohmae, R. Oka, 2003, The Journal of biological chemistry.

Title An aberrant sugar modification of BACE 1 blocks its lysosomal targeting inAlzheimer ' s disease

M. Staufenbiel, N. Taniguchi, Yasuhiko Kizuka, 2019 .

Clec4g (LSECtin) interacts with BACE1 and suppresses Aβ generation

N. Taniguchi, Yasuhiko Kizuka, S. Kitazume, 2015, FEBS letters.

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

M. Staufenbiel, N. Taniguchi, Yasuhiko Kizuka, 2015, EMBO molecular medicine.

Protein Tyrosine Phosphatase Receptor Type Z in Central Nervous System Disease

S. Kitazume, M. Fujii, Kenichiro Nagai, 2022, International journal of molecular sciences.

Involvement of proteases in glycosyltransferase secretion: Alzheimer's β-secretase-dependent cleavage and a following processing by an aminopeptidase

S. Kitazume, T. Saido, Minoru Suzuki, 2004, Glycoconjugate Journal.

In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase.

H. Yonekawa, M. Citron, N. Taniguchi, 2005, The Journal of biological chemistry.

Screening a series of sialyltransferases for possible BACE1 substrates

Young-Choon Lee, S. Kitazume, R. Oka, 2006, Glycoconjugate Journal.

Brain Endothelial Cells Produce Amyloid β from Amyloid Precursor Protein 770 and Preferentially Secrete the O-Glycosylated Form*

Y. Wada, N. Taniguchi, S. Kitazume, 2010, The Journal of Biological Chemistry.

The Absence of Core Fucose Up-regulates GnT-III and Wnt Target Genes

Y. Wada, N. Taniguchi, Yasuhiko Kizuka, 2014, The Journal of Biological Chemistry.

A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models.

T. Betsuyaku, K. Ohtsubo, N. Taniguchi, 2017, American journal of physiology. Lung cellular and molecular physiology.

Reactivity of anti-HNK-1 antibodies to branched O-mannose glycans associated with demyelination.

Katsunori Tanaka, N. Taniguchi, Yasuhiko Kizuka, 2017, Biochemical and biophysical research communications.

Loss of Branched O-Mannosyl Glycans in Astrocytes Accelerates Remyelination

J. Maeda, N. Taniguchi, M. Higuchi, 2013, The Journal of Neuroscience.

High affinity sugar ligands of C-type lectin receptor langerin.

T. Betsuyaku, N. Taniguchi, Yasuhiko Kizuka, 2018, Biochimica et biophysica acta. General subjects.

Glycosylation of Amyloid β-Precursor Protein

S. Kitazume, 2014 .

Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency

P. Paré, E. Silverman, A. Gemma, 2017, Respirology.

Isolation and identification of novel sulfated and nonsulfated oligosialyl glycosphingolipids from sea urchin sperm

A. Dell, H. Morris, S. Kitazume, 1996, Glycoconjugate Journal.

Development of sandwich enzyme-linked immunosorbent assay systems for plasma beta-galactoside alpha2,6-sialyltransferase, a possible hepatic disease biomarker.

S. Kitazume, R. Oka, Y. Hagiwara, 2009, Analytica chimica acta.

Interleukin‐1β up‐regulates TACE to enhance α‐cleavage of APP in neurons: resulting decrease in Aβ production

S. Kitazume, S. Murayama, T. Saido, 2008 .

ST6 Beta-Galactoside Alpha-2,6-Sialyltranferase 1 (ST6GAL1)

S. Kitazume, 2014 .

Core fucose is essential glycosylation for CD14-dependent Toll-like receptor 4 and Toll-like receptor 2 signalling in macrophages

N. Taniguchi, S. Kitazume, T. Takehara, 2018, Journal of biochemistry.

Interaction of Platelet Endothelial Cell Adhesion Molecule (PECAM) with α2,6-Sialylated Glycan Regulates Its Cell Surface Residency and Anti-apoptotic Role*

Katsunori Tanaka, N. Taniguchi, S. Kitazume, 2014, The Journal of Biological Chemistry.

Identification of polysialic acid-containing glycoprotein in the jelly coat of sea urchin eggs. Occurrence of a novel type of polysialic acid structure.

S. Kitazume, K. Kitajima, S. Inoue, 1994, The Journal of biological chemistry.

Detection, isolation, and characterization of oligo/poly(sialic acid) and oligo/poly(deaminoneuraminic acid) units in glycoconjugates.

S. Kitazume, K. Kitajima, S. Inoue, 1992, Analytical biochemistry.

α2,6-Sialic Acid on Platelet Endothelial Cell Adhesion Molecule (PECAM) Regulates Its Homophilic Interactions and Downstream Antiapoptotic Signaling*

J. Marth, N. Taniguchi, S. Kojima, 2010, The Journal of Biological Chemistry.

and negatively by OLIG2

N. Taniguchi, Yasuhiko Kizuka, S. Kitazume, 2014 .

Ceramide galactosyltransferase expression is regulated positively by Nkx2.2 and negatively by OLIG2.

N. Taniguchi, Yasuhiko Kizuka, S. Kitazume, 2014, Glycobiology.

Use of glycan-targeted antibodies/lectins to study the expression/function of glycosyltransferases in the nervous system.

N. Taniguchi, Yasuhiko Kizuka, S. Kitazume, 2014, Advances in neurobiology.

Analytical methods for identifying and quantitating deamidated sialic acid (2-keto-3-deoxy-D-glycero-D-galactonononic acid) and alpha 2----8-linked poly(oligo)nonulosonate residues in glycoconjugates.

S. Kitazume, K. Kitajima, S. Inoue, 1992, Analytical biochemistry.

Glyco-redox, a link between oxidative stress and changes of glycans: Lessons from research on glutathione, reactive oxygen and nitrogen species to glycobiology.

Keiichiro Suzuki, K. Ohtsubo, N. Taniguchi, 2016, Archives of biochemistry and biophysics.

Influence of SIGLEC 9 polymorphisms on COPD phenotypes including exacerbation 1 frequency 2 3

P. Paré, E. Silverman, A. Gemma, 2016 .

Sweet role of platelet endothelial cell adhesion molecule in understanding angiogenesis.

N. Taniguchi, S. Kitazume, Kazuko Ogawa, 2014, Glycobiology.

Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta production.

S. Kitazume, S. Murayama, T. Saido, 2008, Journal of neurochemistry.

Amyloid precursor protein 770 is specifically expressed and released from platelets

Y. Takeishi, S. Kitazume, T. Misaka, 2020, The Journal of Biological Chemistry.

Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters.

Katsunori Tanaka, S. Noguchi, N. Taniguchi, 2017, Chemical communications.

Binding of langerin/CD207 to keratan sulfate disaccharide, Gal (6SO3) β1, 4-GlcNAc (6SO3) and its triangle derivative in vitro and in vivo: possible drug targets for COPD (chronic obstructive pulmonary disease)

Naoyuki Taniguchi, Tomoko Betsuyaku, Bernd Lepenies, 2014 .

A cascading reaction sequence involving ligand-directed azaelectrocyclization and autooxidation-induced fluorescence recovery enables visualization of target proteins on the surfaces of live cells.

Katsunori Tanaka, N. Taniguchi, S. Kitazume, 2014, Organic & biomolecular chemistry.

Total transferrin in cerebrospinal fluid is a novel biomarker for spontaneous intracranial hypotension

M. Miyajima, M. Nakajima, S. Kitazume, 2021, Fukushima journal of medical science.

N‐Glycosylation is essential for the secretion of extracellular superoxide dismutase

N. Taniguchi, Yasuhiko Kizuka, S. Kitazume, 2016, FEBS letters.

Regulation of Heparan Sulfate 6-O-Sulfation by β-Secretase Activity*

S. Kitazume, N. Nagai, H. Toyoda, 2007, Journal of Biological Chemistry.

Pathophysiology of sialyltransferases cleavage by Alzheimer's · -secretase

M. Higuchi, S. Kitazume, T. Saido, 2006 .

Life-Style Related Disease and Aging

K. Ohtsubo, Kazuro Furukawa, N. Taniguchi, 2019, Glycoscience: Basic Science to Applications.

Parsing Out the Roles of Glycosphingolipids Oligodendrocyte Development and Myelin Biogenesis

D. Kirschner, N. Taniguchi, Adrienne M. Luoma, 2015 .

Cell surface and in vivo interaction of dendrimeric N-glycoclusters

Katsunori Tanaka, N. Taniguchi, S. Kitazume, 2015, Glycoconjugate Journal.

Synthesis of CMP-deaminoneuraminic acid (CMP-KDN) using the CTP:CMP-3-deoxynonulosonate cytidylyltransferase from rainbow trout testis. Identification and characterization of a CMP-KDN synthetase.

T. Terada, S. Kitazume, K. Kitajima, 1993, The Journal of biological chemistry.

Non-classical glycosylation determines intracellular trafficking of APP and Aβ production

S. Kitazume, M. Nakano, J. Iijima, 2022, bioRxiv.

Identification, characterization, and developmental expression of a novel α2 → 8-KDN-transferase which terminates elongation of α2 → 8-linked oligo-polysialic acid chain synthesis in trout egg polysialoglycoproteins

T. Terada, S. Kitazume, K. Kitajima, 1994, Glycoconjugate Journal.

Dual impacts of a glycan shield on the envelope glycoprotein B of HSV-1: evasion from human antibodies in vivo and neurovirulence

S. Kitazume, Akihisa Kato, Naoto Koyanagi, 2022, bioRxiv.

A Reduction-Based Sensor for Acrolein Conjugates with the Inexpensive Nitrobenzene as an Alternative to Monoclonal Antibody

Katsunori Tanaka, N. Taniguchi, S. Kitazume, 2016, Scientific Reports.

Sialylation of extracellular superoxide dismutase (EC-SOD) enhances furin-mediated cleavage and secretion

N. Taniguchi, Yasuhiko Kizuka, S. Kitazume, 2017, Glycobiology.

Core fucose is critical for CD14-dependent Toll-like receptor 4 signaling

N. Taniguchi, Yasuhiko Kizuka, S. Kitazume, 2017, Glycobiology.

β-Galactoside α2,6-Sialyltransferase I Cleavage by BACE1 Enhances the Sialylation of Soluble Glycoproteins

J. Marth, N. Taniguchi, S. Kitazume, 2007, Journal of Biological Chemistry.

Alzheimer's β-secretase cleaves a glycosyltransferase as a physiological substrate

S. Kitazume, T. Saido, Y. Hashimoto, 2003, Glycoconjugate Journal.

Alzheimer's β-secretase, β-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

S. Kitazume, R. Oka, T. Saido, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Identification of Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 (ENPP3) as a Regulator of N-Acetylglucosaminyltransferase GnT-IX (GnT-Vb)*

K. Ohtsubo, N. Taniguchi, S. Kitazume, 2013, The Journal of Biological Chemistry.

Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions.

N. Taniguchi, Yasuhiko Kizuka, S. Kitazume, 2016, The Biochemical journal.

Visualizing Trimming Dependence of Biodistribution and Kinetics with Homo- and Heterogeneous N-Glycoclusters on Fluorescent Albumin

H. Onoe, Yasuyoshi Watanabe, Katsunori Tanaka, 2016, Scientific Reports.

Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics

S. Kitazume, T. Natsume, Y. Kawaguchi, 2020, Nature Communications.

KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine.

S. Kitazume, T. Saido, Y. Kiso, 2004, Bioorganic & medicinal chemistry letters.

Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation

V. Nizet, A. Gemma, K. Ohtsubo, 2013, Cellular and Molecular Life Sciences.

The Inhibitory Role of α2,6-Sialylation in Adipogenesis*

N. Taniguchi, Yasuhiko Kizuka, S. Kitazume, 2016, The Journal of Biological Chemistry.

Soluble protein tyrosine phosphatase receptor type Z (PTPRZ) in cerebrospinal fluid is a potential diagnostic marker for glioma

Kiyoshi Saito, S. Kitazume, M. Fujii, 2020, Neuro-oncology advances.

Integrated approach toward the discovery of glyco‐biomarkers of inflammation‐related diseases

K. Ohtsubo, N. Taniguchi, S. Kitazume, 2012, Annals of the New York Academy of Sciences.

Brain-specific Expression of N-Acetylglucosaminyltransferase IX (GnT-IX) Is Regulated by Epigenetic Histone Modifications*

N. Taniguchi, Yasuhiko Kizuka, S. Kitazume, 2011, The Journal of Biological Chemistry.

Glycation vs. glycosylation: a tale of two different chemistries and biology in Alzheimer’s disease

N. Taniguchi, Yasuhiko Kizuka, S. Kitazume, 2016, Glycoconjugate Journal.

Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation

V. Nizet, A. Gemma, A. Varki, 2013, Cellular and Molecular Life Sciences.

Excess APP O-glycosylation by GalNAc-T6 decreases A&bgr; production

S. Kitazume, S. Murayama, S. Hisanaga, 2017, Journal of biochemistry.

Association of serum interleukin‐27 with the exacerbation of chronic obstructive pulmonary disease

A. Gemma, K. Ohtsubo, N. Taniguchi, 2014, Physiological reports.

Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice

S. Kitazume, N. Sahara, T. Saido, 2022, The Journal of biological chemistry.

A single dose of lipopolysaccharide into mice with emphysema mimics human chronic obstructive pulmonary disease exacerbation as assessed by micro-computed tomography.

Naoyuki Taniguchi, Tomoko Betsuyaku, Manabu Ueno, 2013, American journal of respiratory cell and molecular biology.

Mass Isotopomer Analysis of Metabolically Labeled Nucleotide Sugars and N- and O-Glycans for Tracing Nucleotide Sugar Metabolisms*

K. Ohtsubo, N. Taniguchi, S. Kitazume, 2013, Molecular & Cellular Proteomics.

Recent Advances in the Modeling of Alzheimer’s Disease

B. Winblad, E. Sasaki, A. Yoshiki, 2022, Frontiers in Neuroscience.

Sensitivity of Heterozygous α1,6-Fucosyltransferase Knock-out Mice to Cigarette Smoke-induced Emphysema

T. Betsuyaku, K. Ohtsubo, N. Taniguchi, 2012, The Journal of Biological Chemistry.

Sialylation enhances the secretion of neurotoxic amyloid‐β peptides

S. Kitazume, R. Oka, T. Saido, 2006 .

Developmental expression of trout egg polysialoglycoproteins and the prerequisite alpha 2,6-, and alpha 2,8-sialyl and alpha 2,8-polysialyltransferase activities required for their synthesis during oogenesis.

S. Kitazume, K. Kitajima, S. Inoue, 1994, The Journal of biological chemistry.

Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC.

K. Ohtsubo, N. Taniguchi, S. Kitazume, 2010, Glycobiology.

CD22-Binding Synthetic Sialosides Regulate B Lymphocyte Proliferation Through CD22 Ligand-Dependent and Independent Pathways, and Enhance Antibody Production in Mice

H. Takematsu, J. Marth, N. Ito, 2018, Front. Immunol..

Characterization of α2,6-Sialyltransferase Cleavage by Alzheimer's β-Secretase (BACE1)*

S. Kitazume, N. Dohmae, R. Oka, 2003, The Journal of Biological Chemistry.

Fucosylated surfactant protein-D is a biomarker candidate for the development of chronic obstructive pulmonary disease.

N. Taniguchi, Yasuhiko Kizuka, S. Kitazume, 2015, Journal of proteomics.

Characterization of Drosophila aspartic proteases that induce the secretion of a Golgi-resident transferase, heparan sulfate 6-O-sulfotransferase.

T. Aigaki, S. Kitazume, H. Nakato, 2005, Journal of Biochemistry (Tokyo).

Beta-galactoside alpha2,6-sialyltransferase I cleavage by BACE1 enhances the sialylation of soluble glycoproteins. A novel regulatory mechanism for alpha2,6-sialylation.

J. Marth, N. Taniguchi, S. Kitazume, 2007, The Journal of biological chemistry.

High Throughput ELISAs to Measure a Unique Glycan on Transferrin in Cerebrospinal Fluid: A Possible Extension toward Alzheimer's Disease Biomarker Development

M. Miyajima, H. Arai, A. Kuno, 2011, International journal of Alzheimer's disease.

Glycosylation controls cooperative PECAM-VEGFR2-β3 integrin functions at the endothelial surface for tumor angiogenesis

N. Taniguchi, S. Kojima, Yasuhiko Kizuka, 2018, Oncogene.

α1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to elastase-induced emphysema in mice and a possible non-invasive predictive marker for disease progression and exacerbations in chronic obstructive pulmonary disease (COPD).

T. Betsuyaku, M. Nishimura, A. Gemma, 2012, Biochemical and biophysical research communications.

A unique N-glycan on human transferrin in CSF: a possible biomarker for iNPH

M. Miyajima, H. Arai, A. Kuno, 2012, Neurobiology of Aging.

S. Kitazume, 2020 .

Endothelial expression of human APP leads to cerebral amyloid angiopathy in mice

N. Taniguchi, S. Kitazume, N. Sahara, 2020, bioRxiv.

Soluble amyloid precursor protein 770 is a novel biomarker candidate for acute coronary syndrome

Y. Takeishi, N. Taniguchi, S. Kitazume, 2013, Proteomics. Clinical applications.

Soluble Amyloid Precursor Protein 770 Is Released from Inflamed Endothelial Cells and Activated Platelets

H. Arai, Y. Takeishi, N. Taniguchi, 2012, The Journal of Biological Chemistry.

Cell surface and in vivo interaction of dendrimeric N-glycoclusters

Katsunori Tanaka, N. Taniguchi, S. Kitazume, 2015, Glycoconjugate Journal.

O-GalNAc glycosylation determines intracellular trafficking of APP and Aβ production

Yasuhiko Kizuka, S. Kitazume, M. Nakano, 2023, The Journal of biological chemistry.

Brain‐specific glycosylation of protein tyrosine phosphatase receptor type Z (PTPRZ) marks a demyelination‐associated astrocyte subtype

H. Hirase, A. Kakita, H. Takebayashi, 2023, Journal of neurochemistry.

Sialylation enhances the secretion of neurotoxic amyloid-beta peptides.

S. Kitazume, R. Oka, T. Saido, 2006, Journal of neurochemistry.

In Vivo Cleavage of α2,6-Sialyltransferase by Alzheimer β-Secretase*

H. Yonekawa, M. Citron, N. Taniguchi, 2005, Journal of Biological Chemistry.

Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth

K. Ueda, S. Kitazume, M. Fujii, 2023, The Journal of biological chemistry.

Processing of Glycosyltransferases by Alzheimer’s β-secretase (BACE1)

S. Kitazume, S. Takashima, Y. Hashimoto, 2008 .

Uncatalyzed Click Reaction between Phenyl Azides and Acrolein: 4-Formyl-1,2,3-Triazolines as “Clicked” Markers for Visualizations of Extracellular Acrolein Released from Oxidatively Stressed Cells

Katsunori Tanaka, N. Taniguchi, S. Kitazume, 2016 .

N-glycan and Alzheimer's disease.

N. Taniguchi, Yasuhiko Kizuka, S. Kitazume, 2017, Biochimica et biophysica acta. General subjects.

Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions.

N. Taniguchi, Yasuhiko Kizuka, S. Kitazume, 2016, The Biochemical journal.

Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC.

K. Ohtsubo, N. Taniguchi, S. Kitazume, 2010, Glycobiology.

A cascading reaction sequence involving ligand-directed azaelectrocyclization and autooxidation-induced fluorescence recovery enables visualization of target proteins on the surfaces of live cells.

Katsunori Tanaka, N. Taniguchi, S. Kitazume, 2014, Organic & biomolecular chemistry.