J. Lynch

发表

Investigating the Mechanism by Which Gain-of-function Mutations to the α1 Glycine Receptor Cause Hyperekplexia*

Yan Zhang, A. Bode, Bindi Nguyen, 2016, The Journal of Biological Chemistry.

Molecular structure and function of the glycine receptor chloride channel.

J. Lynch, Joseph W Lynch, 2004, Physiological reviews.

Dihydropyridine inhibition of the glycine receptor: Subunit selectivity and a molecular determinant of inhibition

J. Lynch, R. Harvey, B. Cromer, 2009, Neuropharmacology.

Effects of polyunsaturated fatty acids on voltage‐gated K+ and Na+ channels in rat olfactory receptor neurons

J. Lynch, B. Seebungkert, 2002, The European journal of neuroscience.

Action potentials initiated by single channels opening in a small neuron (rat olfactory receptor).

P. H. Barry, J. Lynch, P H Barry, 1989, Biophysical journal.

Phosphorylation of α3 glycine receptors induces a conformational change in the glycine-binding site.

Q. Wang, J. Lynch, Q. Shan, 2013, ACS chemical neuroscience.

Ligand-gated channels

P. H. Barry, J. Lynch, P.H. Barry, 2005, IEEE Transactions on NanoBioscience.

Asymmetric contribution of a and b subunits to the activation of ab heteromeric glycine receptors

J. Lynch, Q. Shan, S. Nevin, 2003 .

Ligand-specific Conformational Changes in the α1 Glycine Receptor Ligand-binding Domain*

J. Lynch, S. Pless, 2009, The Journal of Biological Chemistry.

Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease

J. van Brederode, M. Topf, C. Alzheimer, 2017, The Journal of Neuroscience.

Magnitude of a Conformational Change in the Glycine Receptor β1-β2 Loop Is Correlated with Agonist Efficacy*

Stephan A. Pless, J. Lynch, S. Pless, 2009, The Journal of Biological Chemistry.

Ivermectin, an Unconventional Agonist of the Glycine Receptor Chloride Channel*

J. Lynch, Q. Shan, J. Haddrill, 2001, The Journal of Biological Chemistry.

Fluorescence-Based High-Throughput Functional Profiling of Ligand-Gated Ion Channels at the Level of Single Cells

J. Lynch, Daniel F. Gilbert, S. Talwar, 2013, PloS one.

Selective Modulators of α5-Containing GABAA Receptors and their Therapeutic Significance.

J. Lynch, M. Soh, M. S. Soh, 2015, Current drug targets.

Native glycine receptor subtypes and their physiological roles

J. Lynch, Joseph W. Lynch, 2009, Neuropharmacology.

Phosphorylation of the α2 glycine receptor induces an extracellular conformational change and slows the rise and decay rates of glycinergic synaptic currents

J. Lynch, Xiumin Chen, Argel Estrada-Mondragón, 2018, bioRxiv.

Glycine Receptor Drug Discovery.

Yan Zhang, J. Lynch, S. Talwar, 2017, Advances in pharmacology.

The Free Zinc Concentration in the Synaptic Cleft of Artificial Glycinergic Synapses Rises to At least 1 μM

Yan Zhang, A. Keramidas, J. Lynch, 2016, Front. Mol. Neurosci..

Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations

Yan Zhang, A. Keramidas, J. Lynch, 2015, Neuropharmacology.

The impact of human hyperekplexia mutations on glycine receptor structure and function

A. Bode, J. Lynch, 2014, Molecular Brain.

Stoichiometry and subunit arrangement of α1β glycine receptors as determined by atomic force microscopy.

J. Lynch, E. Taran, T. Webb, 2012, Biochemistry.

A glycine residue essential for high ivermectin sensitivity in Cys-loop ion channel receptors.

J. Lynch, T. Lynagh, 2010, International journal for parasitology.

Structure‐activity analysis of ginkgolide binding in the glycine receptor pore

J. Lynch, T. Lynagh, Judith A. Heads, 2008, Journal of neurochemistry.

Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors

J. Kelly, A. Keramidas, J. Lynch, 2022, Cell & bioscience.

Proteostasis Regulators Restore Function of Epilepsy-Associated GABAA Receptors.

A. Keramidas, J. Lynch, Xiao-Jing Di, 2020, Cell chemical biology.

Loss, Gain and Altered Function of GlyR α2 Subunit Mutations in Neurodevelopmental Disorders

J. Lynch, R. Harvey, Xiumin Chen, 2022, Frontiers in Molecular Neuroscience.

Ivermectin binding sites in human and invertebrate Cys-loop receptors.

J. Lynch, T. Lynagh, 2012, Trends in pharmacological sciences.

Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions

Chengyu Liu, R. Petralia, D. Castellano, 2019, Science.

High-Throughput Screening of Neuronal Cl- Channels: Why and How?

J. Lynch, 2005 .

Effects of GluN2A and GluN2B gain-of-function epilepsy mutations on synaptic currents mediated by diheteromeric and triheteromeric NMDA receptors

A. Keramidas, J. Lynch, R. Harvey, 2020, Neurobiology of Disease.

Effects of GABAA Receptor α3 Subunit Epilepsy Mutations on Inhibitory Synaptic Signaling

P. Sah, Nela Durisic, J. Lynch, 2020, Frontiers in Molecular Neuroscience.

SAHA (Vorinostat) Corrects Inhibitory Synaptic Deficits Caused by Missense Epilepsy Mutations to the GABAA Receptor γ2 Subunit

Nela Durisic, A. Keramidas, J. Lynch, 2018, Front. Mol. Neurosci..

Exon-skipping Splice Variants of Excitatory Amino Acid Transporter-2 (EAAT2) Form Heteromeric Complexes with Full-length EAAT2*

R. Vandenberg, J. Lynch, P. Dodd, 2010, The Journal of Biological Chemistry.

Chimera construction using multiple-template-based sequential PCRs

J. Lynch, Q. Shan, 2010, Journal of Neuroscience Methods.

Glycine receptors in GtoPdb v.2021.3

J. Lynch, L. Sivilotti, T. Smart, 2021, IUPHAR/BPS Guide to Pharmacology CITE.

Structure/Function Studies of the α4 Subunit Reveal Evolutionary Loss of a GlyR Subtype Involved in Startle and Escape Responses

K. Kawakami, M. Suster, A. Bode, 2018, Front. Mol. Neurosci..

Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus

Bindi Nguyen, A. Keramidas, J. Lynch, 2017, PLoS pathogens.

Probing the Structural Mechanism of Partial Agonism in Glycine Receptors Using the Fluorescent Artificial Amino Acid, ANAP.

Nela Durisic, A. Keramidas, J. Lynch, 2017, ACS chemical biology.

Gain-of-function glycine receptor mutants and hyperekplexia

Yan Zhang, A. Bode, Bindi Nguyen, 2016 .

An Improved Ivermectin-activated Chloride Channel Receptor for Inhibiting Electrical Activity in Defined Neuronal Populations*

J. Lynch, T. Lynagh, 2010, The Journal of Biological Chemistry.

Glycine receptors: a new therapeutic target in pain pathways.

R. Callister, J. Lynch, 2006, Current opinion in investigational drugs.

Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine.

R. Vandenberg, J. Lynch, R. Harvey, 2008, Biochemical pharmacology.

Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels

J. Lynch, G. King, J. Stow, 2015, Scientific Reports.

The effects of insecticides on two splice variants of the glutamate‐gated chloride channel receptor of the major malaria vector, Anopheles gambiae

A. Keramidas, J. Lynch, M. Atif, 2020, British journal of pharmacology.

Multiplexed labeling of viable cells for high‐throughput analysis of glycine receptor function using flow cytometry

J. Lynch, G. Osborne, V. Nink, 2009, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Identification of a New Ligand Binding Domain in the α1 Subunit of the Inhibitory Glycine Receptor

P. Schofield, T. Lewis, J. Lynch, 1999, Journal of neurochemistry.

An outline of desensitization in pentameric ligand-gated ion channel receptors

A. Keramidas, J. Lynch, 2013, Cellular and Molecular Life Sciences.

Startle disease mutations reduce the agonist sensitivity of the human inhibitory glycine receptor.

P. Schofield, J. Lynch, C. French, 1994, The Journal of biological chemistry.

A missense mutation in the gene encoding the α1 subunit of the inhibitory glycine receptor in the spasmodic mouse

P. O'Connell, P. Schofield, R. Shiang, 1994, Nature Genetics.

Liquid junction potentials and small cell effects in patch-clamp analysis

J. Lynch, Joseph W. Lynch, Peter H. Barry, 1991, The Journal of Membrane Biology.

Differential expression of glycine receptor subunits in the rat basolateral and central amygdala

P. Sah, A. Delaney, J. Lynch, 2010, Neuroscience Letters.

Mechanism of action of the insecticides, lindane and fipronil, on glycine receptor chloride channels

J. Lynch, R. Islam, 2012, British journal of pharmacology.

Subunit-specific potentiation of recombinant glycine receptors by NV-31, a bilobalide-derived compound

J. Lynch, Xuebin Chen, 2008, Neuroscience Letters.

Molecular determinants of ginkgolide binding in the glycine receptor pore

M. Parker, J. Lynch, B. Cromer, 2006, Journal of neurochemistry.

Molecular Determinants of Ivermectin Sensitivity at the Glycine Receptor Chloride Channel*

J. Lynch, B. Cromer, T. Lynagh, 2011, The Journal of Biological Chemistry.

Nitric Oxide Inhibition of the Rat Olfactory Cyclic Nucleotide-Gated Cation Channel

J. Lynch, 1998, The Journal of Membrane Biology.

Characterization of Calcium-activated Chloride Channels in Patches Excised from the Dendritic Knob of Mammalian Olfactory Receptor Neurons

J. Lynch, P. Barry, M. Hallani, 1998, The Journal of Membrane Biology.

Properties of cyclic nucleotide-gated channels mediating olfactory transduction. Activation, selectivity, and blockage

S. Frings, B. Lindemann, J. Lynch, 1992, The Journal of general physiology.

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit

K. Roche, A. Keramidas, J. Lynch, 2021, bioRxiv.

Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin

J. Lynch, T. Lynagh, Joseph W. Lynch, 2012, Front. Mol. Neurosci..

Molecular pharmacology of the glycine receptor chloride channel.

J. Lynch, Joseph W Lynch, T. Webb, 2007, Current pharmaceutical design.

The glycine receptor.

P. Schofield, J. Lynch, Peter R. Schofield, 1997, Pharmacology & therapeutics.

A Novel Glycine Receptor Variant with Startle Disease Affects Syndapin I and Glycinergic Inhibition

Yan Zhang, A. Keramidas, J. Lynch, 2020, The Journal of Neuroscience.

Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease

M. Topf, R. Thomas, A. Bode, 2013, Neurobiology of Disease.

GLRB is the third major gene of effect in hyperekplexia.

B. Weschke, R. Shiang, M. Parker, 2013, Human molecular genetics.

Pathophysiological Mechanisms of Dominant and Recessive GLRA1 Mutations in Hyperekplexia

F. Andermann, R. Shiang, E. Andermann, 2010, The Journal of Neuroscience.

Generation of Functional Inhibitory Synapses Incorporating Defined Combinations of GABA(A) or Glycine Receptor Subunits

Yan Zhang, J. Lynch, C. Dixon, 2015, Front. Mol. Neurosci..

Correlating Structural and Energetic Changes in Glycine Receptor Activation*

A. Keramidas, J. Lynch, Suzanne Scott, 2015, The Journal of Biological Chemistry.

GABAA Receptor α and γ Subunits Shape Synaptic Currents via Different Mechanisms*

P. Sah, A. Keramidas, J. Lynch, 2014, The Journal of Biological Chemistry.

New Hyperekplexia Mutations Provide Insight into Glycine Receptor Assembly, Trafficking, and Activation Mechanisms*

E. Karam, H. Mandel, S. Berkovic, 2013, The Journal of Biological Chemistry.

Sesterterpene glycinyl-lactams: a new class of glycine receptor modulator from Australian marine sponges of the genus Psammocinia.

Frank Fontaine, Robiul Islam, Xue Xiao, 2013, Organic & biomolecular chemistry.

High Throughput Techniques for Discovering New Glycine Receptor Modulators and their Binding Sites

Robiul Islam, Timothy Lynagh, J. Lynch, 2009, Front. Mol. Neurosci..

A yellow fluorescent protein-based assay for high-throughput screening of glycine and GABAA receptor chloride channels

S. Frings, J. Lynch, D. Hryciw, 2005, Neuroscience Letters.

Function of hyperekplexia‐causing α1R271Q/L glycine receptors is restored by shifting the affected residue out of the allosteric signalling pathway

J. Lynch, Q. Shan, Lu Han, 2012, British journal of pharmacology.

Conformational Variability of the Glycine Receptor M2 Domain in Response to Activation by Different Agonists*

H. Lester, J. Lynch, M. Dibas, 2007, Journal of Biological Chemistry.

Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel

P. Schofield, J. Lynch, K. Pierce, 1997, The EMBO journal.

Mutation of an arginine residue in the human glycine receptor transforms β-alanine and taurine from agonists into competitive antagonists

P. Schofield, J. Lynch, C. French, 1995, Neuron.

The permeation of organic cations through cAMP-gated channels in mammalian olfactory receptor neurons

J. Lynch, P. Barry, S. Balasubramanian, 1995, The Journal of Membrane Biology.

Tropisetron modulation of the glycine receptor: femtomolar potentiation and a molecular determinant of inhibition

M. Parker, J. Lynch, B. Cromer, 2007, Journal of neurochemistry.

Mutations Affecting the Glycine Receptor Agonist Transduction Mechanism Convert the Competitive Antagonist, Picrotoxin, into an Allosteric Potentiator (*)

P. Schofield, J. Lynch, P. Barry, 1995, The Journal of Biological Chemistry.

Structure-Function Analysis of the GlyR α2 Subunit Autism Mutation p.R323L Reveals a Gain-of-Function

Thi Thao Nguyen Ho, Yan Zhang, A. Keramidas, 2017, Frontiers in Molecular Neuroscience.

Rigor, reproducibility, and in vitro cerebrospinal fluid assays: The devil in the details

A. Jenkins, J. Lynch, D. Rye, 2017, Annals of neurology.

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Mehdi Mobli, Glenn F. King, Vi Pham, 2017, Proceedings of the National Academy of Sciences.

A common inhibitory binding site for zinc and odorants at the voltage‐gated K+ channel of rat olfactory receptor neurons

J. Lynch, Benchamaporn Seebungkert, 2001, The European journal of neuroscience.

Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity

N. Harrison, A. Keramidas, J. Lynch, 2015, British journal of pharmacology.

The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes.

P. Schofield, G. Sutherland, J. Lynch, 1996, Brain research. Molecular brain research.

Inhibitory synapse deficits caused by familial α1 GABAA receptor mutations in epilepsy

Nela Durisic, A. Keramidas, J. Lynch, 2017, Neurobiology of Disease.

Cyclic nucleotide-gated channels of rat olfactory receptor cells: divalent cations control the sensitivity to cAMP

B. Lindemann, J. Lynch, Joseph W. Lynch, 1994, The Journal of general physiology.

An analysis of Na+ currents in rat olfactory receptor neurons

J. Lynch, P. Barry, S. Rajendra, 1992, Pflügers Archiv.

Odorant-induced currents in intact patches from rat olfactory receptor neurons: theory and experiment.

J. Lynch, P. Chiu, P. Barry, 1997, Biophysical journal.

Concentration Dependence of Sodium Permeation and Sodium Ion Interactions in the Cyclic AMP-gated Channels of Mammalian Olfactory Receptor Neurons

J. Lynch, P. Barry, S. Balasubramanian, 1997, The Journal of Membrane Biology.

A pore-lining glutamic acid in the rat olfactory cyclic nucleotide-gated channel controls external spermine block

J. Lynch, S. Nevin, J. Haddrill, 2000, Neuroscience Letters.

Rectification of the Olfactory Cyclic Nucleotide-Gated Channel by Intracellular Polyamines

J. Lynch, 1999, The Journal of Membrane Biology.

Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator.

Frank Fontaine, Robiul Islam, Xue Xiao, 2013, Bioorganic & medicinal chemistry.

Zolpidem and Eszopiclone prime α 1 β 2 γ 2 GABA A receptors for longer duration activity 1

N. Harrison, A. Keramidas, J. Lynch, 2015 .

Phosphorylation mediated structural and functional changes in pentameric ligand-gated ion channels: implications for drug discovery.

J. Lynch, S. Talwar, 2014, The international journal of biochemistry & cell biology.

γ1-Containing GABA-A Receptors Cluster at Synapses Where they Mediate Slower Synaptic Currents than γ2-Containing GABA-A Receptors

P. Sah, Nela Durisic, A. Keramidas, 2017, Front. Mol. Neurosci..

Incompatibility between a Pair of Residues from the Pre-M1 Linker and Cys-loop Blocks Surface Expression of the Glycine Receptor*

J. Lynch, Q. Shan, 2012, The Journal of Biological Chemistry.

The impact of human hyperekplexia mutations on glycine receptor structure and function

A. Bode, J. Lynch, 2014, Molecular Brain.

Molecular determinants of β‐carboline inhibition of the glycine receptor

J. Lynch, B. Cromer, Xuebin Chen, 2009, Journal of neurochemistry.

A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore

M. Parker, J. Lynch, R. Harvey, 2007, Journal of neurochemistry.

Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear

P. Fitzgerald, R. Marek, P. Sah, 2018, Nature Neuroscience.

Glycine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

J. Lynch, L. Sivilotti, T. Smart, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae.

Frank Fontaine, Robiul Islam, Andrew M. Piggott, 2010, Bioorganic & medicinal chemistry.

Comparison of Taurine- and Glycine-induced Conformational Changes in the M2-M3 Domain of the Glycine Receptor*

J. Clements, J. Lynch, N. Han, 2004, Journal of Biological Chemistry.

The Surface Accessibility of the Glycine Receptor M2–M3 Loop Is Increased in the Channel Open State

P. Schofield, J. Lynch, J. Haddrill, 2001, The Journal of Neuroscience.

Function of hyperekplexia-causing α1R271Q/L glycine receptors is restored by shifting the affected residue out of the allosteric signaling pathway* Running title: restoration of mutant glycine receptor function

J. Lynch, Q. Shan, Lu Han, 2011 .

GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance

Jennifer J. Smith, A. Keramidas, J. Lynch, 2019, PLoS pathogens.

Insights into the Structural Basis for Zinc Inhibition of the Glycine Receptor*

M. Parker, C. Morton, J. Lynch, 2003, Journal of Biological Chemistry.

Zinc Potentiation of the Glycine Receptor Chloride Channel Is Mediated by Allosteric Pathways

P. Schofield, J. Lynch, K. Pierce, 1998, Journal of neurochemistry.

Calcium-dependent Modulation of the Agonist Affinity of the Mammalian Olfactory Cyclic Nucleotide-gated Channel by Calmodulin and a Novel Endogenous Factor

J. Lynch, P. Barry, S. Balasubramanian, 1996, The Journal of Membrane Biology.

A lipid site shapes the agonist response of a pentameric ligand-gated ion channel

D. Bertrand, E. Pardon, J. Steyaert, 2019, Nature Chemical Biology.

A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models

T. Woodruff, J. Lynch, M. Hodson, 2015, Neurobiology of Disease.

A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line.

J. Lynch, V. Lemos, K. Takeda, 1994, The Journal of biological chemistry.

ILLUMINATING THE STRUCTURE AND FUNCTION OF CYS‐LOOP RECEPTORS

J. Lynch, S. Pless, 2008, Clinical and experimental pharmacology & physiology.

A Picrotoxin-specific Conformational Change in the Glycine Receptor M2–M3 Loop*

J. Lynch, Rebecca L. Hawthorne, 2005, Journal of Biological Chemistry.

β Subunit M2–M3 Loop Conformational Changes Are Uncoupled from α1 β Glycine Receptor Channel Gating: Implications for Human Hereditary Hyperekplexia

J. Lynch, Q. Shan, Lu Han, 2011, PloS one.

Distinct conformational changes in activated agonist‐bound and agonist‐free glycine receptor subunits

J. Lynch, S. Pless, 2009, Journal of neurochemistry.

Asymmetric contribution of α and β subunits to the activation of αβ heteromeric glycine receptors

J. Lynch, Q. Shan, S. Nevin, 2003 .

A single β subunit M2 domain residue controls the picrotoxin sensitivity of αβ heteromeric glycine receptor chloride channels

J. Lynch, Q. Shan, J. Haddrill, 2001 .

Asymmetric contribution of alpha and beta subunits to the activation of alphabeta heteromeric glycine receptors.

J. Lynch, Q. Shan, S. Nevin, 2003, Journal of neurochemistry.

A single beta subunit M2 domain residue controls the picrotoxin sensitivity of alphabeta heteromeric glycine receptor chloride channels.

J. Lynch, Q. Shan, J. Haddrill, 2001, Journal of neurochemistry.

A Cation-π Interaction at a Phenylalanine Residue in the Glycine Receptor Binding Site Is Conserved for Different Agonists

H. Lester, S. Lummis, J. Lynch, 2011, Molecular Pharmacology.

A Cation-π Interaction in the Binding Site of the Glycine Receptor Is Mediated by a Phenylalanine Residue

H. Lester, S. Lummis, J. Lynch, 2008, The Journal of Neuroscience.

Characterization of a glycine receptor domain that controls the binding and gating mechanisms of the β‐amino acid agonist, taurine

J. Lynch, J. Haddrill, N. Han, 2001, Journal of neurochemistry.

The M4 transmembrane segment contributes to agonist efficacy differences between α1 and α3 glycine receptors

J. Lynch, Xuebin Chen, T. Webb, 2009, Molecular membrane biology.

Comparative Surface Accessibility of a Pore-lining Threonine Residue (T6′) in the Glycine and GABAA Receptors*

J. Lynch, Q. Shan, J. Haddrill, 2002, The Journal of Biological Chemistry.

BUILDING NEW FUNCTION INTO GLYCINE RECEPTORS: A STRUCTURAL MODEL FOR THE ACTIVATION OF THE GLYCINE‐GATED CHLORIDE CHANNEL

J. Lynch, N. Han, Peter R. Schofield, 1999, Clinical and experimental pharmacology & physiology.

Ligand-Gated Ion Channels: Permeation and Activation 1

J. Lynch, P. Barry, 2007 .

The prokaryote ligand-gated ion channel ELIC captured in a pore blocker-bound conformation by the Alzheimer's disease drug memantine.

G. Tresadern, C. Ulens, A. J. Thompson, 2014, Structure.

Analysis of Hyperekplexia Mutations Identifies Transmembrane Domain Rearrangements That Mediate Glycine Receptor Activation*

A. Bode, J. Lynch, 2013, The Journal of Biological Chemistry.

Distinct Properties of Glycine Receptor β+/α− Interface

J. Lynch, Q. Shan, Lu Han, 2012, The Journal of Biological Chemistry.

A comparison of glycine- and ivermectin-mediated conformational changes in the glycine receptor ligand-binding domain.

J. Lynch, Qian Wang, 2012, The international journal of biochemistry & cell biology.

Ligand- and Subunit-specific Conformational Changes in the Ligand-binding Domain and the TM2-TM3 Linker of α1 β2 γ2 GABAA Receptors*

J. Lynch, S. Pless, Qian Wang, 2010, The Journal of Biological Chemistry.

HOMOMERIC PROTEIN INTERFACE RECONSTITUTED IN CHARACTERIZING HETEROMERIC Interface : UNAMBIGUOUSLY − α + / β Distinct Properties of Glycine Receptor Neurobiology

J. Lynch, Q. Shan, Lu Han, 2012 .

Functional characterization of ivermectin binding sites in α1β2γ2L GABA(A) receptors

J. Lynch, Argel Estrada-Mondragón, 2015, Front. Mol. Neurosci..

Investigating ion channel conformational changes using voltage clamp fluorometry

J. Lynch, S. Talwar, 2015, Neuropharmacology.

Properties of transient K+ currents and underlying single K+ channels in rat olfactory receptor neurons

J. Lynch, P. Barry, 1991, The Journal of general physiology.

Closed-state Cross-linking of Adjacent β1 Subunits in α1β1 GABAa Receptors via Introduced 6′ Cysteines*

J. Lynch, T. Webb, Zhe Yang, 2007, Journal of Biological Chemistry.

Activation and Desensitization Induce Distinct Conformational Changes at the Extracellular-Transmembrane Domain Interface of the Glycine Receptor*

J. Lynch, Qian Wang, 2011, The Journal of Biological Chemistry.

Physiological and pharmacological properties of inhibitory postsynaptic currents mediated by α5β1γ2, α5β2γ2 and α5β3γ2 GABAA receptors

A. Keramidas, J. Lynch, Xiumin Chen, 2017, Neuropharmacology.

GABA A receptors and inhibitory neurotransmission in the amygdalar complex

P. Sah, J. Lynch, M. B. Perumal, 2018 .

Ivermectin-Activated, Cation-Permeable Glycine Receptors for the Chemogenetic Control of Neuronal Excitation.

P. Sah, Nela Durisic, A. Keramidas, 2016, ACS chemical neuroscience.

Mauthner Neuron of the Zebrafish Embryo Development of Spontaneous Glycinergic Currents in the

E. Puil, E. Brustein, P. Legendre, 2015 .

Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear

P. Fitzgerald, R. Marek, P. Sah, 2018, Nature Neuroscience.

A temperature and solution control system for the measurement of single channel currents in excised membrane patches

J. Lynch, N. Quartararo, P. Barry, 1988, Pflügers Archiv.

Slowly activating K+ channels in rat olfactory receptor neurons

J. Lynch, P. Barry, 1991, Proceedings of the Royal Society of London. Series B: Biological Sciences.

An outline of desensitization in pentameric ligand-gated ion channel receptors

A. Keramidas, J. Lynch, 2012, Cellular and Molecular Life Sciences.

Optimizing the Expression of Recombinant αβγ GABAA Receptors in HEK293 Cells for High-Throughput Screening

J. Lynch, A. Esmaeili, Daniel F. Gilbert, 2009, Journal of biomolecular screening.

GABAA receptors containing gamma1 subunits contribute to inhibitory transmission in the central amygdala.

P. Sah, J. Lynch, A. Esmaeili, 2009, Journal of neurophysiology.