V. Gerzanich

J. Simard, V. Gerzanich, S. K. Woo, 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Mechanisms of Global Cerebral Edema Formation in Aneurysmal Subarachnoid Hemorrhage

J. Simard, K. Sheth, V. Gerzanich, 2017, Neurocritical Care.

Blast-induced brain injury in rats leads to transient vestibulomotor deficits and persistent orofacial pain

A. Keller, J. Simard, V. Gerzanich, 2018, Brain injury.

Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis

J. Simard, C. Bever, S. Ivanova, 2017, Journal of Neuroinflammation.

Autocrine TGF-beta1 mediates angiotensin II-induced proliferative response of cerebral vessels in vivo.

J. Simard, S. Ivanova, V. Gerzanich, 2007, American journal of hypertension.

Glibenclamide Reduces Inflammation, Vasogenic Edema, and Caspase-3 Activation after Subarachnoid Hemorrhage

J. Simard, S. Ivanova, V. Gerzanich, 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

TRPM4 and the Emperor

J. Simard, V. Gerzanich, 2017, Channels.

Inducible nitric oxide synthase (NOS-2) in subarachnoid hemorrhage: Regulatory mechanisms and therapeutic implications

J. Simard, D. Kurland, V. Gerzanich, 2016, Brain circulation.

Alternative Splicing of cGMP-Dependent Protein Kinase I in Angiotensin-Hypertension: Novel Mechanism for Nitrate Tolerance in Vascular Smooth Muscle

J. Simard, S. Ivanova, V. Gerzanich, 2003, Circulation research.

Chronic Nicotine Alters NO Signaling of Ca2+ Channels in Cerebral Arterioles

J. Simard, G. A. West, V. Gerzanich, 2001, Circulation research.

Adenylate cyclase 5 and KCa1.1 channel are required for EGFR up‐regulation of PCNA in native contractile rat basilar artery smooth muscle

S. Ivanova, V. Gerzanich, O. Tsymbalyuk, 2006, The Journal of physiology.

7,8-Dihydroxyflavone improves neuropathological changes in the brain of Tg26 mice, a model for HIV-associated neurocognitive disorder

C. Bever, A. Heredia, V. Gerzanich, 2020, Scientific Reports.

Molecular Mechanisms of Microvascular Failure in CNS Injury – Synergistic Roles of NKCC1 and SUR1/TRPM4

J. Simard, V. Gerzanich, K. Kahle, 2011 .

Genome-Wide Characterization of SARS-CoV-2 Cytopathogenic Proteins in the Search of Antiviral Targets

J. Simard, V. Gerzanich, Qiyi Tang, 2022, mBio.

Glibenclamide Reduces Inflammation, Vasogenic Edema, and Caspase-3 Activation after Subarachnoid Hemorrhage

J. Simard, S. Ivanova, V. Gerzanich, 2009 .

regulated NC Ca-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury

J. Simard, S. Ivanova, V. Gerzanich, 2007 .

Sulfonylurea Receptor 1, Transient Receptor Potential Cation Channel Subfamily M Member 4, and KIR6.2:Role in Hemorrhagic Progression of Contusion

J. Simard, B. Aarabi, S. Ivanova, 2019, Journal of neurotrauma.

Glibenclamide—10-h Treatment Window in a Clinically Relevant Model of Stroke

J. Simard, S. Ivanova, V. Gerzanich, 2012, Translational Stroke Research.

Brief Suppression of Abcc8 Prevents Autodestruction of Spinal Cord After Trauma

J. Simard, M. Norenberg, S. Ivanova, 2010, Science Translational Medicine.

Marc Simard After Trauma Prevents Autodestruction of Spinal Cord Abcc 8 Brief Suppression of

J. Simard, M. Norenberg, S. Ivanova, 2010 .

Suppression of Abcc 8 Prevents Autodestruction of Spinal Cord After Trauma

J. Simard, M. Norenberg, S. Ivanova, 2010 .

Endothelial sulfonylurea receptor 1-regulated NC Ca-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury.

J. Simard, S. Ivanova, V. Gerzanich, 2007, The Journal of clinical investigation.

Angiogenesis induced by prenatal ischemia predisposes to periventricular hemorrhage during postnatal mechanical ventilation

J. Simard, S. Ivanova, V. Gerzanich, 2014, Pediatric Research.

Activation of (Na (cid:1) (cid:1) K (cid:1) )-ATPase Modulates Cardiac L-Type Ca 2 (cid:1) Channel Function

Dong I. Lee, V. Gerzanich, R. Xiao, 2009 .

Pharmacological induced target temperature management after cardiac arrest: the capsaicinoids

J. Simard, X. Jia, V. Gerzanich, 2017, Neural regeneration research.

Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus

J. Simard, M. Gunel, R. Medzhitov, 2017, Nature Medicine.

Inflammation of the Choroid Plexus and Ependymal Layer of the Ventricle Following Intraventricular Hemorrhage

J. Simard, S. Ivanova, V. Gerzanich, 2011, Translational Stroke Research.

Sphingolipids and transient receptor potential channels: evolutionarily ancient families now joined.

J. Simard, V. Gerzanich, 2006, Circulation research.

Rodent model of direct cranial blast injury.

J. Simard, S. Ivanova, G. Bochicchio, 2011, Journal of neurotrauma.

Chronic nicotine treatment up-regulates alpha3 and alpha7 acetylcholine receptor subtypes expressed by the human neuroblastoma cell line SH-SY5Y.

V. Gerzanich, J. Lindstrom, X. Peng, 1997, Molecular pharmacology.

Heparin Reduces Neuroinflammation and Transsynaptic Neuronal Apoptosis in a Model of Subarachnoid Hemorrhage

J. Simard, S. Ivanova, D. Kurland, 2012, Translational Stroke Research.

Selective Vulnerability of the Foramen Magnum in a Rat Blast Traumatic Brain Injury Model.

J. Simard, V. Gerzanich, Adam Pampori, 2018, Journal of neurotrauma.

Chronic Nicotine Exposure Differentially Affects the Function of Human a 3 , a 4 , and a 7 Neuronal Nicotinic Receptor Subtypes 1

V. Gerzanich, J. Lindstrom, A. Kuryatov, 1997 .

Early pathophysiological changes in cerebral vessels predisposing to stroke.

J. Simard, S. Ivanova, V. Gerzanich, 2003, Clinical hemorheology and microcirculation.

Hemorrhagic progression of a contusion after traumatic brain injury: a review.

Bizhan Aarabi, J. Simard, B. Aarabi, 2012, Journal of neurotrauma.

Key role of sulfonylurea receptor 1 in progressive secondary hemorrhage after brain contusion.

Grant Bochicchio, J. Simard, S. Ivanova, 2009, Journal of neurotrauma.

Cytotoxic edema: mechanisms of pathological cell swelling.

J. Simard, M. Simard, V. Gerzanich, 2007, Neurosurgical focus.

Precision Effects of Glibenclamide on MRI Endophenotypes in Clinically Relevant Murine Traumatic Brain Injury

J. Simard, P. Kochanek, R. Jha, 2022, Critical care medicine.

alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors.

V. Gerzanich, J. Lindstrom, A. Kuryatov, 1998, The Journal of pharmacology and experimental therapeutics.

Chronic Nicotine Treatment Up-Regulates α3 and α7 Acetylcholine Receptor Subtypes Expressed by the Human Neuroblastoma Cell Line SH-SY5Y

V. Gerzanich, J. Lindstrom, R. Anand, 1997 .

Neuronal Nicotinic Receptor Subtypes

V. Gerzanich, J. Lindstrom, JON LINDSTROM, 1995, Annals of the New York Academy of Sciences.

Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover.

P. Whiting, V. Gerzanich, J. Lindstrom, 1994, Molecular pharmacology.

Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes.

R Anand, V. Gerzanich, J. Lindstrom, 1994, Molecular pharmacology.

Glibenclamide in Cerebral Ischemia and Stroke

J. Simard, K. Sheth, G. D. del Zoppo, 2014, Neurocritical Care.

Brivaracetam attenuates pain behaviors in a murine model of neuropathic pain

J. Simard, S. Ivanova, V. Gerzanich, 2019, Molecular pain.

Traumatic brain injury alters dendritic cell differentiation and distribution in lymphoid and non-lymphoid organs

M. Simard, V. Gerzanich, O. Tsymbalyuk, 2021, bioRxiv.

Emerging therapeutic targets for cerebral edema

J. Simard, R. Jha, S. Desai, 2021, Expert opinion on therapeutic targets.

SUR1‐TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling

J. Simard, V. Gerzanich, S. K. Woo, 2018, Glia.

Molecular pathophysiology of cerebral edema

J. Simard, V. Gerzanich, J. Stokum, 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Heterogeneity of aquaporin-4 localization and expression after focal cerebral ischemia underlies differences in white versus grey matter swelling

J. Simard, S. Ivanova, V. Gerzanich, 2015, Acta neuropathologica communications.

Mechanisms of Astrocyte-Mediated Cerebral Edema

J. Simard, D. Kurland, V. Gerzanich, 2015, Neurochemical Research.

A novel method to study cerebrospinal fluid dynamics in rats

J. Simard, D. Kurland, V. Gerzanich, 2015, Journal of Neuroscience Methods.

Neuronal Nicotinic Receptor Structure and Function

V. Gerzanich, J. Lindstrom, R. Anand, 1995 .

Complications Associated with Decompressive Craniectomy: A Systematic Review

J. Simard, J. Sahuquillo, D. Kurland, 2015, Neurocritical Care.

The peroxisome proliferator-activated receptor gamma (PPARγ) agonist, rosiglitazone, ameliorates neurofunctional and neuroinflammatory abnormalities in a rat model of Gulf War Illness

J. Simard, S. Ivanova, S. Negoita, 2020, PloS one.

Biomarkers as outcome predictors in subarachnoid hemorrhage – a systematic review

J. Simard, M. Simard, D. Kurland, 2014, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

Mannitol and Hypertonic Saline Reduce Swelling and Modulate Inflammatory Markers in a Rat Model of Intracerebral Hemorrhage

J. Simard, S. Ivanova, V. Gerzanich, 2018, Neurocritical Care.

Heparin Reduces Neuroinflammation and Transsynaptic Neuronal Apoptosis in a Model of Subarachnoid Hemorrhage

J. Simard, S. Ivanova, D. Kurland, 2012, Translational Stroke Research.

Newly expressed SUR1-regulated NCCa-ATP channel mediates cerebral edema after ischemic stroke

J. Simard, G. A. West, S. Ivanova, 2006, Nature Medicine.

Chronic pain after blast-induced traumatic brain injury in awake rats

A. Keller, J. Simard, V. Gerzanich, 2019, Neurobiology of pain.

Chronic nicotine exposure differentially affects the function of human alpha3, alpha4, and alpha7 neuronal nicotinic receptor subtypes.

V. Gerzanich, J. Lindstrom, A. Kuryatov, 1997, The Journal of pharmacology and experimental therapeutics.

Molecular mechanisms of microvascular failure in central nervous system injury--synergistic roles of NKCC1 and SUR1/TRPM4.

J. Simard, V. Gerzanich, K. Kahle, 2010, Journal of neurosurgery.

Functional Properties of Human Nicotinic Achrs Expressed by Imr-32 Neuroblastoma Cells Resemble Those of α3β4 Achrs Expressed in Permanently Transfected Hek Cells

Fan Wang, V. Gerzanich, J. Lindstrom, 2001, The Journal of general physiology.

Homomers of alpha 8 and alpha 7 subunits of nicotinic receptors exhibit similar channel but contrasting binding site properties.

R Anand, V. Gerzanich, J. Lindstrom, 1994, Molecular pharmacology.

Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications

J. Simard, T. Kent, V. Gerzanich, 2007, The Lancet Neurology.

Chlorotoxin‐sensitive Ca2+‐activated Cl− channel in type R2 reactive astrocytes from adult rat brain

J. Simard, V. Gerzanich, Y. Shuba, 2003, Glia.

Complex N-Glycosylation Stabilizes Surface Expression of Transient Receptor Potential Melastatin 4b Protein*

J. Simard, V. Gerzanich, S. K. Woo, 2013, The Journal of Biological Chemistry.

Non-selective cation channels, transient receptor potential channels and ischemic stroke.

J. Simard, V. Gerzanich, K. Tarasov, 2007, Biochimica et biophysica acta.

Sulfonylurea Receptor 1 Expression in Human Cerebral Infarcts

J. Simard, S. Ivanova, R. Castellani, 2013, Journal of Neuropathology and Experimental Neurology.

The Sulfonylurea Receptor 1 (Sur1)-Transient Receptor Potential Melastatin 4 (Trpm4) Channel

J. Simard, V. Gerzanich, S. K. Woo, 2012, The Journal of Biological Chemistry.

Sulfonylurea receptor 1 in central nervous system injury: a focused review

J. Simard, V. Gerzanich, S. K. Woo, 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Disruption of Ion Homeostasis in the Neurogliovascular Unit Underlies the Pathogenesis of Ischemic Cerebral Edema

J. Simard, B. Walcott, V. Gerzanich, 2014, Translational Stroke Research.

Cerebral microbleeds in a neonatal rat model

J. Simard, S. Ivanova, V. Gerzanich, 2017, PloS one.

Tandem insults of prenatal ischemia plus postnatal raised intrathoracic pressure in a novel rat model of encephalopathy of prematurity.

J. Simard, M. Koltz, S. Ivanova, 2011, Journal of neurosurgery. Pediatrics.

Glibenclamide pretreatment protects against chronic memory dysfunction and glial activation in rat cranial blast traumatic brain injury

J. Simard, V. Gerzanich, J. Karimy, 2017, Behavioural Brain Research.

Analysis of 3-(4-hydroxy, 2-Methoxybenzylidene)anabaseine selectivity and activity at human and rat alpha-7 nicotinic receptors.

R. Papke, V. Gerzanich, J. Lindstrom, 1998, The Journal of pharmacology and experimental therapeutics.

Activation of (Na++K+)-ATPase Modulates Cardiac L-Type Ca2+ Channel Function

Dong I. Lee, V. Gerzanich, R. Xiao, 2009, Molecular Pharmacology.

a 5 Subunit Alters Desensitization , Pharmacology , Ca 11 Permeability and Ca 11 Modulation of Human Neuronal a 3 Nicotinic Receptors 1

V. Gerzanich, J. Lindstrom, A. Kuryatov, 1998 .

Mislocalization of eNOS and Upregulation of Cerebral Vascular Ca2+ Channel Activity in Angiotensin-Hypertension

J. Simard, S. Ivanova, V. Gerzanich, 2003, Hypertension.

Immunomodulatory therapy with glatiramer acetate reduces endoplasmic reticulum stress and mitochondrial dysfunction in experimental autoimmune encephalomyelitis

C. Bever, M. Simard, V. Gerzanich, 2021, bioRxiv.

PCNA Up-Regulation in Cerebral Vessels with Angiotensin II-Hypertension: Abnormal Regulation of Ca2+ Channel and Nitrate Tolerance Associated with Alternative Splicing of cGKI

J. Simard, M. Shuba, S. Ivanova, 2003, Neurophysiology.

Direct versus indirect actions of ghrelin on hypothalamic NPY neurons

J. Simard, V. Routh, J. Bryan, 2017, PloS one.

The Protective Effect of Glibenclamide in a Model of Hemorrhagic Encephalopathy of Prematurity

J. Simard, M. Koltz, S. Ivanova, 2013, Brain sciences.

Sulfonylurea Receptor 1 in the Germinal Matrix of Premature Infants

J. Simard, M. Koltz, S. Ivanova, 2008, Pediatric Research.

The Sur1-Trpm4 Channel in Spinal Cord Injury.

J. Simard, B. Aarabi, V. Gerzanich, 2013, Journal of spine.

Progressive Hemorrhagic Necrosis - A Unique Pheno- type of Capillary Fragmentation

J. Simard, B. Aarabi, V. Gerzanich, 2013 .

Comparative effects of glibenclamide and riluzole in a rat model of severe cervical spinal cord injury

J. Simard, S. Ivanova, V. Gerzanich, 2012, Experimental Neurology.

A large portion of the astrocyte proteome is dedicated to perivascular endfeet, including critical components of the electron transport chain

J. Simard, V. Gerzanich, Weiliang Huang, 2021, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Mutation Causing Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Alters Ca2+ Permeability, Conductance, and Gating of Human α4β2 Nicotinic Acetylcholine Receptors

V. Gerzanich, A. Kuryatov, F. Olale, 1997, The Journal of Neuroscience.

Structure and function of neuronal nicotinic acetylcholine receptors.

V. Gerzanich, J. Lindstrom, G. Wells, 1996, Progress in brain research.

Trans-Cellular Proliferating Cell Nuclear Antigen Gene Activation in Cerebral Vascular Smooth Muscle by Endothelial Oxidative Injury In Vivo

J. Simard, S. Ivanova, V. Gerzanich, 2003, Arteriosclerosis, thrombosis, and vascular biology.

A Direct Comparison of Three Clinically Relevant Treatments in a Rat Model of Cervical Spinal Cord Injury

J. Simard, S. Ivanova, P. Popovich, 2015, Journal of neurotrauma.

Sur1-Trpm4 Cation Channel Expression in Human Cerebral Infarcts

J. Simard, S. Ivanova, R. Castellani, 2015, Journal of neuropathology and experimental neurology.

Exposure of the thorax to a sublethal blast wave causes a hydrodynamic pulse that leads to perivenular inflammation in the brain.

J. Simard, S. Ivanova, V. Gerzanich, 2014, Journal of neurotrauma.

Glibenclamide—10-h Treatment Window in a Clinically Relevant Model of Stroke

J. Simard, S. Ivanova, V. Gerzanich, 2012, Translational Stroke Research.

Glibenclamide Reduces Hippocampal Injury and Preserves Rapid Spatial Learning in a Model of Traumatic Brain Injury

J. Simard, V. Gerzanich, Zhihua Geng, 2010, Journal of neuropathology and experimental neurology.

Molecular and Antigenic Structure of Nicotinic Acetylcholine Receptors

V. Gerzanich, A. Kuryatov, G. Wells, 1998, Annals of the New York Academy of Sciences.

Transient receptor potential melastatin 4 and cell death

J. Simard, V. Gerzanich, S. K. Woo, 2012, Pflügers Archiv - European Journal of Physiology.

The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia

J. Simard, J. Bryan, M. Freichel, 2016, Journal of Neuroinflammation.

Silencing of Abcc8 or inhibition of newly upregulated Sur1-Trpm4 reduce inflammation and disease progression in experimental autoimmune encephalomyelitis

J. Simard, C. Bever, S. Ivanova, 2015, Journal of Neuroinflammation.

Glibenclamide for the Treatment of Acute CNS Injury

J. Simard, D. Kurland, V. Gerzanich, 2013, Pharmaceuticals.

Spinal cord injury with unilateral versus bilateral primary hemorrhage — Effects of glibenclamide

J. Simard, P. Popovich, V. Gerzanich, 2012, Experimental Neurology.

Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke

J. Simard, S. Ivanova, R. Jha, 2023, Science Signaling.

Reporter epitopes: a novel approach to examine transmembrane topology of integral membrane proteins applied to the alpha 1 subunit of the nicotinic acetylcholine receptor.

R Anand, V. Gerzanich, J. Lindstrom, 1993, Biochemistry.

Functional Properties of Human Nicotinic AChRs Expressed by IMR-32 Neuroblastoma Cells Resemble Those of (cid:2) 3 (cid:3) 4 AChRs Expressed in Permanently Transfected HEK Cells

V. Gerzanich, A. Kuryatov, Catherine H. Choi, 2001 .

Determinants of channel gating located in the N-terminal extracellular domain of nicotinic α7 receptor

V. Gerzanich, J. Lindstrom, G. Wells, 1998, Journal of Physiology-Paris.

Correlation of HIV-Induced Neuroinflammation and Synaptopathy with Impairment of Learning and Memory in Mice with HAND

J. Simard, V. Gerzanich, J. Bryant, 2023, Journal of clinical medicine.

Region-Specific Homeostatic Identity of Astrocytes Is Essential for Defining Their Response to Pathological Insults

J. Simard, N. Makarava, I. Baskakov, 2023, Cells.

Region-specific homeostatic identity of astrocytes is essential for defining their reactive phenotypes following pathological insults

J. Simard, N. Makarava, I. Baskakov, 2023, bioRxiv.

IL-6 in traumatic brain injury: A Janus-faced player in damage and repair.

J. Simard, V. Gerzanich, P. Ciryam, 2023, Journal of neurotrauma.

Inhibition of the Sur1-Trpm4 Channel Reduces Neuroinflammation and Cognitive Impairment in Subarachnoid Hemorrhage

V. Gerzanich, S. K. Woo, Rupal I. Mehta, 2013, Stroke.

Protective Effect of Delayed Treatment With Low-Dose Glibenclamide in Three Models of Ischemic Stroke

J. Simard, S. Ivanova, V. Gerzanich, 2009, Stroke.

A novel method to study cerebrospinal fluid dynamics in rats

J. Simard, V. Gerzanich, J. Karimy, 2015, Journal of Neuroscience Methods.

Tandem insults of prenatal ischemia plus postnatal raised intrathoracic pressure in a novel rat model of encephalopathy of prematurity.

S. Ivanova, V. Gerzanich, Ç. Tosun, 2011, Journal of neurosurgery. Pediatrics.

Brain Swelling versus Infarct Size: A Problematizing Review

V. Gerzanich, Natalya Tsymbalyuk, K. Keledjian, 2024, Brain sciences.

&agr;-Endosulfine (ARPP-19e) Expression in a Rat Model of Stroke

S. Ivanova, V. Gerzanich, N. Tsymbalyuk, 2017, Journal of neuropathology and experimental neurology.

Transient receptor potential melastatin 4 and cell death

V. Gerzanich, S. K. Woo, J. Simard, 2012, Pflügers Archiv - European Journal of Physiology.

Mechanisms of Astrocyte-Mediated Cerebral Edema

V. Gerzanich, J. Stokum, J. Simard, 2014, Neurochemical Research.

MRI evidence that glibenclamide reduces acute lesion expansion in a rat model of spinal cord injury

V. Gerzanich, J. Caridi, O. Tsymbalyuk, 2013, Spinal Cord.

Adenosine-A2a receptor down-regulates cerebral smooth muscle L-type Ca2+ channel activity via protein tyrosine phosphatase, not cAMP-dependent protein kinase.

J. Simard, H. Winn, G. A. West, 2003, Molecular pharmacology.

Adenosine-A 2 a Receptor Down-Regulates Cerebral Smooth Muscle L-Type Ca 2 Channel Activity via Protein Tyrosine Phosphatase , Not cAMP-Dependent Protein Kinase

J. Simard, H. Winn, G. A. West, 2003 .