P. Croucher

P. Croucher, L. Kottam, I. Bellantuono, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The Fas/Fas Ligand System Inhibits Differentiation of Murine Osteoblasts but Has a Limited Role in Osteoblast and Osteoclast Apoptosis1

P. Croucher, V. Katavic, I. Lukić, 2007, The Journal of Immunology.

Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts

R. H. Bassett, A. Boyde, P. Croucher, 2010, Proceedings of the National Academy of Sciences.

Interleukin‐6 is expressed by plasma cells from patients with multiple myeloma and monoclonal gammopathy of undetermined significance

P. Croucher, M. Greaves, J. Lawry, 1998, British journal of haematology.

Human myeloma cells shed the interleukin‐6 receptor: inhibition by tissue inhibitor of metalloproteinase‐3 and a hydroxamate‐based metalloproteinase inhibitor

P. Croucher, J. Lawry, R. Russell, 1998, British journal of haematology.

BONE DISEASE IN MULTIPLE MYELOMA

P. Croucher, J. Apperley, 1998, British journal of haematology.

Inhibiting activin‐A signaling stimulates bone formation and prevents cancer‐induced bone destruction in vivo

M. Bouxsein, P. Croucher, T. Arnett, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Rapid phenotyping of knockout mice to identify genetic determinants of bone strength

P. Croucher, B. Freudenthal, J. Bassett, 2016, The Journal of endocrinology.

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

David M. Evans, D. Kiel, M. Nalls, 2018, American journal of human genetics.

Genome-wide association study of extreme high bone mass: Contribution of common genetic variation to extreme BMD phenotypes and potential novel BMD-associated genes

David M. Evans, M. Brown, M. Marshall, 2018, Bone.

CHAPTER 6 – Growth Factors

P. Croucher, P. Hulley, Graham A Russell, 2006 .

The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer

I. Holen, P. Croucher, Ning Wang, 2015, Journal of experimental & clinical cancer research : CR.

The anti-tumor potential of zoledronic acid.

P. Croucher, S. Jagdev, R. Coleman, 2003, Breast.

Multiple myeloma biology: lessons from the 5TMM models

P. Croucher, K. Vanderkerken, B. Van Camp, 2003, Immunological reviews.

N-ethyl-N-Nitrosourea (ENU) Induced Mutations within the Klotho Gene Lead to Ectopic Calcification and Reduced Lifespan in Mouse Models

Steve D. M. Brown, M. Brown, R. Cox, 2015, PloS one.

Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells.

F. Hamdy, I. Holen, P. Croucher, 2002, Cancer research.

Myeloma impairs mature osteoblast function but causes early expansion of osteo‐progenitors: temporal changes in bone physiology and gene expression in the KMS12BM model

P. Croucher, K. Yong, D. Lath, 2016, British journal of haematology.

The development of novel targeted therapeutics for treatment of multiple myeloma research roundtable

E. Sausville, B. Barlogie, K. Anderson, 2003 .

Bone metastases

A. Padhani, M. Fallon, P. Croucher, 2020, Nature Reviews Disease Primers.

Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancer.

Naveid A Ali, T. Phan, P. Croucher, 2015, Cancer discovery.

Reduced bone formation in non-steroid treated patients with rheumatoid arthritis.

P. Croucher, J. Compston, R. Mellish, 1989, Annals of the rheumatic diseases.

Histomorphometric assessment of trabecular bone remodelling in osteoporosis.

P. Croucher, J. Compston, 1991, Bone and mineral.

Bone Mineral Content and Density.

C. Esapa, P. Croucher, R. Thakker, 2012, Current protocols in mouse biology.

Reduced bone formation in patients with osteoporosis associated with inflammatory bowel disease

P. Croucher, J. Compston, R. Motley, 1993, Osteoporosis International.

P8. Resorption depth and mean interstitial bone thickness (MIBT): age-related changes in man

P. Croucher, J. Compston, N. Garrahan, 1989 .

ELEVATED SERUM INTACT PARATHYROID HORMONE LEVELS IN ELDERLY PATIENTS WITH HIP FRACTURE

R. Brown, P. Croucher, J. Woodhead, 1989, Clinical endocrinology.

Soluble Rank Ligand Produced by Myeloma Cells Causes Generalised Bone Loss in Multiple Myeloma

P. Croucher, K. Yong, M. Lawson, 2012, PloS one.

Expression of interleukin‐1β and tumour necrosis factor‐α in plasma cells from patients with multiple myeloma

P. Croucher, M. Greaves, R. Russell, 1999 .

(2017). Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis. Nature Genetics , , 1468–1475.

Nicole, Jacqueline K. White, C. Greenwood, 2017 .

A Mouse with an N-Ethyl-N-Nitrosourea (ENU) Induced Trp589Arg Galnt3 Mutation Represents a Model for Hyperphosphataemic Familial Tumoural Calcinosis

Steve D. M. Brown, M. Brown, R. Cox, 2012, PloS one.

Denosumab compared with zoledronic acid on PFS in multiple myeloma: exploratory results of an international phase 3 study.

J. Canon, N. Raje, P. Croucher, 2021, Blood advances.

A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to a Col2a1 mutation

Steve D. M. Brown, M. Brown, A. Boyde, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Parathyroid Hormone (PTH) Increases Skeletal Tumour Growth and Alters Tumour Distribution in an In Vivo Model of Breast Cancer

I. Holen, P. Croucher, N. Brown, 2018, International journal of molecular sciences.

Loss of the Vitamin D Receptor in Human Breast Cancer Cells Promotes Epithelial to Mesenchymal Cell Transition and Skeletal Colonization

K. Horas, P. Croucher, M. Seibel, 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma.

I. Holen, P. Croucher, T. Skerry, 2001, Blood.

Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis

P. Croucher, L. Kottam, I. Bellantuono, 2010, Arthritis research & therapy.

PYY is a negative regulator of bone mass and strength

A. Boyde, P. Croucher, R. Batterham, 2019, Bone.

Inhibiting cytokine-processing enzymes

I. Holen, P. Croucher, P. Hargreaves, 2000 .

HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1.

K. Mrozik, C. Cheong, A. Zannettino, 2017, Cancer research.

The combination of bortezomib, melphalan, dexamethasone and intermittent thalidomide is an effective regimen for relapsed/refractory myeloma and is associated with improvement of abnormal bone metabolism and angiogenesis

M. Dimopoulos, D. Heath, P. Croucher, 2008, Leukemia.

Expression of the chemokine receptor CCR1 promotes the dissemination of multiple myeloma plasma cells in vivo

K. Mrozik, A. Zannettino, K. Vandyke, 2020, Haematologica.

The skeletal cell‐derived molecule sclerostin drives bone marrow adipogenesis

J. Pettitt, P. Croucher, C. Rosen, 2018, Journal of cellular physiology.

Mice lacking the calcineurin inhibitor Rcan2 have an isolated defect of osteoblast function.

A. Boyde, P. Croucher, Xiao-yang Sun, 2012, Endocrinology.

Hedgehog signalling is required for perichondral osteoblast differentiation in zebrafish

H. Roehl, P. Croucher, Katharina Felber, 2011, Mechanisms of Development.

Colonic dendritic cells, intestinal inflammation, and T cell-mediated bone destruction are modulated by recombinant osteoprotegerin.

G. Morgan, S. Rollinson, P. Croucher, 2003, Immunity.

Bisphosphonates--mechanisms of action in multiple myeloma.

P. Croucher, M. Rogers, R. Graham, 2000, Acta oncologica.

Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes.

P. Croucher, R. Graham, G. Russell, 1997, Biochemical and biophysical research communications.

Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma.

P. Croucher, K. Vanderkerken, B. Van Camp, 2003, Cancer research.

INTRODUCTION Age-related osteoporosis is associated with an increase in adipocytes and a reciprocal decrease in osteoblast numbers within bone

R. Kelsh, H. Roehl, P. Croucher, 2010 .

Regulation of neural crest cell fate by the retinoic acid and Pparg signalling pathways

R. Kelsh, H. Roehl, P. Croucher, 2010, Development.

Investigating the interaction between osteoprotegerin and receptor activator of NF-kappaB or tumor necrosis factor-related apoptosis-inducing ligand: evidence for a pivotal role for osteoprotegerin in regulating two distinct pathways.

P. Croucher, S. Vitovski, J. Sayers, 2007, The Journal of biological chemistry.

Slc20a2, Encoding the Phosphate Transporter PiT2, Is an Important Genetic Determinant of Bone Quality and Strength

C. Lelliott, P. Croucher, Y. Maugars, 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Melphalan modifies the bone microenvironment by enhancing osteoclast formation

Gholamreza Haffari, J. Pettitt, P. Croucher, 2017, Oncotarget.

Role of CCR1 and CCR5 in homing and growth of multiple myeloma and in the development of osteolytic lesions: a study in the 5TMM model

P. Croucher, K. Miyashita, T. Imanishi, 2006, Clinical & Experimental Metastasis.

Evidence of a role for a non‐matrix‐type metalloproteinase activity in the shedding of syndecan‐1 from human myeloma cells

I. Holen, P. Croucher, P. Hargreaves, 2001, British journal of haematology.

Evidence of a role for osteoprotegerin in the pathogenesis of pulmonary arterial hypertension.

David Evans, D. Crossman, N. Morrell, 2008, The American journal of pathology.

Evidence of a role for RANKL in the development of myeloma bone disease.

P. Croucher, K. Vanderkerken, E. de Leenheer, 2004, Current opinion in pharmacology.

The transcriptome of regenerating zebrafish scales identifies genes involved in human bone disease

E. Zeggini, J. Kemp, J. Zethof, 2020, bioRxiv.

Agonists of TRAIL death receptors induce myeloma cell apoptosis that is not prevented by cells of the bone marrow microenvironment

P. Croucher, R. Russell, C. Edwards, 2007, Leukemia.

Bisphosphonates in multiple myeloma.

P. Croucher, J. Apperley, 1999, Pathologie-biologie.

Cloning of a novel membrane-linked metalloproteinase from human myeloma cells.

P. Croucher, R. Russell, J. Apperley, 1996, The Biochemical journal.

Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells.

P. Croucher, C. Shipman, 2003, Cancer research.

Human Myeloma Cells Ligand and Can Function as a Paracrine Survival Factor for Necrosis Factor-related Apoptosis-inducing Ligand / Apo 2 Osteoprotegerin Is a Soluble Decoy Receptor for Tumor

P. Croucher, C. Shipman, 2003 .

Advances in Brief Osteoprotegerin Is a Soluble Decoy Receptor for Tumor Necrosis Factor-related Apoptosis-inducing Ligand / Apo 2 Ligand and Can Function as a Paracrine Survival Factor for Human Myeloma Cells 1

P. Croucher, C. Shipman, 2003 .

Myeloma cells (5TMM) and their interactions with the marrow microenvironment.

P. Croucher, K. Vanderkerken, E. Menu, 2004, Blood cells, molecules & diseases.

An Essential Physiological Role for MCT8 in Bone in Male Mice

A. Boyde, P. Croucher, R. Weiss, 2017, Endocrinology.

Thyroid Hormone Receptor α Mutation Causes a Severe and Thyroxine-Resistant Skeletal Dysplasia in Female Mice

A. Boyde, T. Zikmund, P. Croucher, 2014, Endocrinology.

Bisphosphonate therapy in the treatment of multiple myeloma.

P. Croucher, M. Lawson, J. Ashcroft, 2010, Current pharmaceutical design.

High titre neutralizing antibodies in response to SARS–CoV–2 infection require RBD–specific CD4 T cells that include proliferative memory cells

T. Phan, A. Kelleher, J. Zaunders, 2022, Frontiers in Immunology.

Targeting the IGF‐1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: Beneficial effects on tumor growth, angiogenesis, bone disease and survival

O. Larsson, M. Axelson, P. Croucher, 2007, International journal of cancer.

The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma.

P. Croucher, M. Rogers, D. Hughes, 2000 .

The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma

P. Croucher, M. Rogers, D. Hughes, 2000, British journal of haematology.

Anti-tumour activity of bisphosphonates in human myeloma cells.

P. Croucher, M. Rogers, R. Graham, 1998, Leukemia & lymphoma.

Low prevalence of osteomalacia in elderly patients with hip fracture.

P. Croucher, J. Compston, S. Vedi, 1991, Age and ageing.

Apoptosisa Limited Role in Osteoblast and Osteoclast Has Differentiation of Murine Osteoblasts but The Fas/Fas Ligand System Inhibits

P. Croucher, V. Katavic, I. Lukić, 2007 .

Characteristics of trabecular bone resorption cavities in patients with chronic renal failure.

A. Williams, P. Croucher, J. Compston, 1992, Bone and mineral.

Multiple Myeloma Progression: Dependence on Bone Marrow Adipose Tissue

P. Croucher, C. Rosen, M. McDonald, 2016 .

A mouse with a Trp589Arg mutation in N-acetylgalactosaminyltransferase 3 (Galnt3) provides a model for familial tumoural calcinosis

M. Brown, R. Cox, C. Esapa, 2009 .

Anti-Sclerostin Treatment Prevents Multiple Myeloma Induced Bone Loss and Reduces Tumor Burden

M. Bouxsein, J. Pettitt, P. Croucher, 2015 .

Tracking gene expression during zebrafish osteoblast differentiation

H. Roehl, P. Croucher, P. Elks, 2009, Developmental dynamics : an official publication of the American Association of Anatomists.

A Mouse with a Ser1386Pro Mutation in the C-propeptide Domain of col2aI Provides a Model for Spondyloepiphyseal Dysplasia Congenita

R. Cox, C. Esapa, P. Croucher, 2008 .

The Forkhead Transcription Factor FOXP2 Is Required for Regulation of p21 in 143B Osteosarcoma Cell Growth Arrest

S. Fisher, A. Banham, P. Croucher, 2020 .

production in osteoblasts by direct interaction with the induced interleukin-6 - metalloproteinase family, regulates myeloma-cell

P. Croucher, A. Karadag, Min Zhou, 2013 .

ADAM-9 (mdc-9/meltrin-γ), a member of the a disintegrin and metalloproteinase family, regulates myeloma cell induced interleukin-6 production in osteoblasts by direct interaction with the αvβ5-integrin

P. Croucher, A. Karadag, Min Zhou, 2006 .

Human Myeloma Cells Promote the Recruitment of Osteoblast Precursors: Mediation by Interleukin‐6 and Soluble Interleukin‐6 Receptor

P. Croucher, A. Scutt, A. Karadag, 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The 5T2MM murine model of multiple myeloma: maintenance and analysis.

P. Croucher, F. Gorus, K. Vanderkerken, 2005, Methods in molecular medicine.

INVESTIGATING THE INTERACTION BETWEEN OSTEOPROTEGERIN AND RANKL OR TRAIL: EVIDENCE FOR A PIVOTAL ROLE FOR OSTEOPROTEGERIN IN REGULATING TWO DISTINCT PATHWAYS

P. Croucher, S. Vitovski, J. Sayers, 2007 .

Osteoprotegerin (OPG) Expression by Breast Cancer Cells in vitro and Breast Tumours in vivo – A Role in Tumour Cell Survival?

S. Cross, I. Holen, S. Balasubramanian, 2005, Breast Cancer Research and Treatment.

Mitotic quiescence, but not unique “stemness,” marks the phenotype of bone metastasis‐initiating cells in prostate cancer

I. Holen, P. Croucher, Ning Wang, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19

José Alquicira-Hernández, T. Phan, A. Kelleher, 2022, Clinical Immunology.

P. Croucher, J. Compston, N. Garrahan, 1991, Osteoporosis International.

A computerised technique for the quantitative assessment of resorption cavities in trabecular bone.

P. Croucher, J. Compston, N. Garrahan, 1990, Bone.

A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength

M. Bouxsein, N. Solban, A. Grinberg, 2012, Proceedings of the National Academy of Sciences.

The effects of gonadotrophin-releasing hormone agonists on iliac crest cancellous bone structure in women with endometriosis.

P. Croucher, J. Compston, P. Lindsay, 1995, Bone.

The use of bisphosphonates in multiple myeloma: recommendations of an expert panel on behalf of the European Myeloma Network.

M. Dimopoulos, P. Sonneveld, J. Miguel, 2009, Annals of oncology : official journal of the European Society for Medical Oncology.

In vivo homing and differentiation characteristics of mature (CD45-) and immature (CD45+) 5T multiple myeloma cells.

P. Croucher, K. Vanderkerken, H. de Raeve, 2001, Experimental hematology.

The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway.

P. Croucher, M. Rogers, R. Russell, 1998, Cancer research.

Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti‐tumour activity

P. Croucher, M. Rogers, R. Russell, 1997, British journal of haematology.

Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes

S. Tangye, F. Luciani, T. Phan, 2018, Nature Communications.

Single Cell RNA Sequencing of Rare Immune Cell Populations

Imogen Moran, Tri Giang Phan, Peter I. Croucher, 2018, Front. Immunol..

A Rare Mutation in SMAD9 Associated With High Bone Mass Identifies the SMAD‐Dependent BMP Signaling Pathway as a Potential Anabolic Target for Osteoporosis

M. Brown, M. Marshall, J. Kemp, 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Rapid-Throughput Skeletal Phenotyping of 100 Knockout Mice Identifies 9 New Genes That Determine Bone Strength

Alan Boyde, Peter I. Croucher, Jacqueline K. White, 2012, PLoS genetics.

Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche

A. Zannettino, T. Phan, J. Pettitt, 2015, Nature Communications.

The dormant cancer cell life cycle

T. Phan, P. Croucher, 2020, Nature Reviews Cancer.

Cancer Cell Dormancy in Metastasis.

P. Croucher, M. McDonald, M. A. Summers, 2019, Cold Spring Harbor perspectives in medicine.

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

Sean C Warren, Max Nobis, Astrid Magenau, 2017, Cell reports.

A rare SMAD9 mutation identifies the BMP signalling pathway as a potential osteoanabolic target

M. Brown, M. Marshall, J. Kemp, 2019, bioRxiv.

Bortezomib alone or in combination with the histone deacetylase inhibitor JNJ-26481585: effect on myeloma bone disease in the 5T2MM murine model of myeloma.

Les Coulton, Karin Vanderkerken, Els Van Valckenborgh, 2009, Cancer research.

The effects of JNJ-26481585, a novel hydroxamate-based histone deacetylase inhibitor, on the development of multiple myeloma in the 5T2MM and 5T33MM murine models

P. Croucher, K. Vanderkerken, E. Menu, 2009, Leukemia.

Gene expression predicts dormant metastatic breast cancer cell phenotype

S. Stewart, T. Phan, P. Croucher, 2022, Breast cancer research : BCR.

Prostate cancer cell‐intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone

Linden J. Gearing, J. Mariadason, N. Corcoran, 2020, EMBO reports.

A Niche-Dependent Myeloid Transcriptome Signature Defines Dormant Myeloma Cells.

I. Amit, K. Vandyke, D. Hose, 2019, Blood.

The Impact of Whole Genome Data on Therapeutic Decision-Making in Metastatic Prostate Cancer: A Retrospective Analysis

N. Corcoran, C. Hovens, E. Chan, 2020, Cancers.

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

J. Kemp, T. Phan, P. Timpson, 2021, Cell.

Next generation mapping reveals novel large genomic rearrangements in prostate cancer

Vanessa M. Hayes, Peter I. Croucher, Desiree C. Petersen, 2017, Oncotarget.

LIST AND AFFILIATIONS

Jacqueline K. White, Evans, Adams, 2017 .

Clonal dynamics of SARS-CoV-2-specific T cells in children and adults with COVID-19

José Alquicira-Hernández, T. Phan, A. Kelleher, 2022, bioRxiv.

Prostate Cancer Cells Preferentially Home to Osteoblast‐rich Areas in the Early Stages of Bone Metastasis: Evidence From In Vivo Models

I. Holen, P. Croucher, Ning Wang, 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Osteoprotegerin (OPG) inhibits the development of osteolytic bone disease in the 5T2MM model of multiple myeloma.

P. Croucher, G. Russell, K. Vanderkerken, 2000 .

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

J. Kemp, T. Phan, P. Timpson, 2021, Cell.

The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel

P. Croucher, S. Jagdev, R. Coleman, 2001, British Journal of Cancer.

An osteoprotegerin-like peptidomimetic inhibits osteoclastic bone resorption and osteolytic bone disease in myeloma.

D. Heath, R. Murali, P. Croucher, 2007, Cancer research.

The Forkhead Transcription Factor FOXP2 Is Required for Regulation of p21WAF1/CIP1 in 143B Osteosarcoma Cell Growth Arrest

S. Fisher, A. Banham, P. Croucher, 2015, PloS one.

Castration-induced bone loss triggers growth of disseminated prostate cancer cells in bone.

I. Holen, P. Croucher, Ning Wang, 2014, Endocrine-related cancer.

DNA Barcoding Reveals Habitual Clonal Dominance of Myeloma Plasma Cells in the Bone Marrow Microenvironment

K. Vandyke, David M. Lawrence, P. Croucher, 2017, Neoplasia.

The pharmacology of bisphosphonates and new insights into their mechanisms of action

P. Croucher, H. Fleisch, J. Frith, 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Targeting Tumour-Initiating Cells with TRAIL Based Combination Therapy Ensures Complete and Lasting Eradication of Multiple Myeloma Tumours In Vivo

P. Croucher, S. Vitovski, M. Lawson, 2012, PloS one.

Bone metastasis: the importance of the neighbourhood

T. Martin, P. Croucher, M. McDonald, 2016, Nature Reviews Cancer.

Metastasis and bone loss: advancing treatment and prevention.

I. Holen, L. Suva, J. Gralow, 2010, Cancer treatment reviews.

An N‐Ethyl‐N‐Nitrosourea (ENU) Mutagenized Mouse Model for Autosomal Dominant Nonsyndromic Kyphoscoliosis Due to Vertebral Fusion

A. Mallon, M. Brown, R. Cox, 2018, JBMR plus.

Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma.

D. Hose, T. Phan, J. Pettitt, 2017, Blood.

Clodronate-Liposome Mediated Macrophage Depletion Abrogates Multiple Myeloma Tumor Establishment In Vivo

K. Mrozik, K. Vandyke, A. Evdokiou, 2019, Neoplasia.

Tumor-host cell interactions in the bone disease of myeloma.

P. Croucher, C. Edwards, J. Fowler, 2011, Bone.

Apoptotic cell fragments locally activate tingible body macrophages in the germinal center

D. Hume, T. Phan, M. Meyer-Hermann, 2023, Cell.

Inhibiting Dickkopf‐1 (Dkk1) Removes Suppression of Bone Formation and Prevents the Development of Osteolytic Bone Disease in Multiple Myeloma

J. Shaughnessy, D. Heath, J. Snowden, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Zoledronic Acid Treatment of 5T2MM‐Bearing Mice Inhibits the Development of Myeloma Bone Disease: Evidence for Decreased Osteolysis, Tumor Burden and Angiogenesis, and Increased Survival

E. van Marck, P. Croucher, K. Vanderkerken, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Prader-Willi Critical Region, a Non-Translated, Imprinted Central Regulator of Bone Mass: Possible Role in Skeletal Abnormalities in Prader-Willi Syndrome

P. Croucher, L. Campbell, P. Baldock, 2016, PloS one.

ADAM-9 (MDC-9/meltrin-gamma), a member of the a disintegrin and metalloproteinase family, regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha(v)beta5 integrin.

P. Croucher, A. Karadag, Min Zhou, 2006, Blood.

A Mouse Model of Early-Onset Renal Failure Due to a Xanthine Dehydrogenase Nonsense Mutation

Steve D. M. Brown, M. Brown, R. Cox, 2012, PloS one.

Signaling Between Tumor Cells and the Host Bone Marrow Microenvironment

P. Croucher, M. McDonald, N. Kovacic, 2013, Calcified Tissue International.

Expression of interleukin-1beta and tumour necrosis factor-alpha in plasma cells from patients with multiple myeloma.

P. Croucher, M. Greaves, R. Russell, 1999, British journal of haematology.

Myeloma bone disease and proteasome inhibition therapies.

M. Dimopoulos, O. Sezer, P. Croucher, 2007, Blood.

Multifunctional role of matrix metalloproteinases in multiple myeloma: a study in the 5T2MM mouse model.

L. Devy, A. Noël, C. Carron, 2004, The American journal of pathology.

Word Count : 4113 Abstract word count : 245 Number of Figures : 7 Number of Supplemental Figures : 2 Number of Supplemental Tables : 1 Number of Supplemental Movies : 0

Hose, Anja, T. Phan, 2017 .

Serum concentrations of Dickkopf‐1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation

M. Dimopoulos, D. Heath, P. Croucher, 2006, International journal of cancer.

Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes.

P. Croucher, Anita Lukić, I. Lukić, 2010, Leukemia research.

M. Dimopoulos, D. Heath, P. Croucher, 2008, Leukemia.

Bortezomib reduces serum dickkopf‐1 and receptor activator of nuclear factor‐κB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma

M. Dimopoulos, D. Heath, P. Croucher, 2006, British journal of haematology.

The bone marrow stromal compartment in multiple myeloma patients retains capability for osteogenic differentiation in vitro: defining the stromal defect in myeloma

P. Croucher, K. Yong, Laura A Percy, 2014, British journal of haematology.

Accelerating functional gene discovery in osteoarthritis

Jacqueline K. White, E. Zeggini, C. Lelliott, 2019, Nature Communications.

An atlas of genetic influences on osteoporosis in humans and mice

David M. Evans, D. Kiel, A. Auton, 2018, Nature Genetics.

Expression of members of the novel membrane linked metalloproteinase family ADAM in cells derived from a range of haematological malignancies.

P. Croucher, N. Mckie, E. Wu, 1997, Biochemical and biophysical research communications.

Murine Models of Myeloma Bone Disease: The Importance of Choice

P. Croucher, J. Epstein, K. Vanderkerken, 2010 .

Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: Evidence from in‐situ synchrotron X‐ray scattering and backscattered electron imaging

Alan Boyde, Angelo Karunaratne, Asa H Barber, 2012, Journal of Bone and Mineral Research.

Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines.

S Bord, P. Croucher, J. Compston, 1992, Journal of cell science.

The relationship between spinal trabecular bone mineral content and iliac crest trabecular bone volume

P. Croucher, J. Compston, N. Garrahan, 2007, Calcified Tissue International.

The relationship between spinal trabecular bone mineral content and iliac crest trabecular bone volume.

P. Croucher, J. Compston, N. Garrahan, 1990, Basic life sciences.

Assessment of cancellous bone structure: Comparison of strut analysis, trabecular bone pattern factor, and marrow space star volume

P. Croucher, J. Compston, P I Croucher, 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Effect of the HDAC inhibitor vorinostat on the osteogenic differentiation of mesenchymal stem cells in vitro and bone formation in vivo

P. Croucher, X. Leleu, K. Vanderkerken, 2013, Acta Pharmacologica Sinica.

OPG‐Fc inhibits ovariectomy‐induced growth of disseminated breast cancer cells in bone

I. Holen, P. Croucher, Ning Wang, 2015, International journal of cancer.

Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density

Steve D. M. Brown, Jacqueline K. White, Elif F. Acar, 2020, PLoS genetics.

Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease

J. Kemp, J. Zethof, G. Flik, 2022, BMC biology.

Effects of hormone replacement therapy on cancellous bone microstructure in postmenopausal women.

P. Croucher, J. Compston, N. Garrahan, 1996, Bone.

Structural mechanisms of trabecular bone loss in man.

R. Newcombe, P. Croucher, J. Compston, 1989, Bone and mineral.

Fas receptor is required for estrogen deficiency-induced bone loss in mice

P. Croucher, Vladimir Grubišić, I. Lukić, 2009, Laboratory Investigation.

The relationship between resorption depth and mean interstitial bone thickness: Age-related changes in man

P. Croucher, J. Compston, R. Mellish, 2007, Calcified Tissue International.

Bisphosphonates and osteoprotegerin as inhibitors of myeloma bone disease

P. Croucher, K. Vanderkerken, B. Van Camp, 2003, Cancer.

Quantitative analysis of trabecular bone structure.

P. Croucher, J. Compston, N. Garrahan, 1993, Bone.

Cancer‐induced bone loss and associated pain‐related behavior is reduced by risedronate but not its phosphonocarboxylate analog NE‐10790

P. Croucher, M. Kassem, F. Ebetino, 2009, International journal of cancer.

Structural mechanisms of trabecular bone loss in primary osteoporosis: specific disease mechanism or early ageing?

P. Croucher, J. Compston, N. Garrahan, 1994, Bone and mineral.

Bone turnover in non-steroid treated rheumatoid arthritis.

P. Croucher, J. Compston, N. Garrahan, 1994, Annals of the rheumatic diseases.

Clinical disorders of bone resorption.

P. Croucher, G. Russell, C. Shipman, 2001, Novartis Foundation symposium.

Multi‐Targeting DKK1 and LRP6 Prevents Bone Loss and Improves Fracture Resistance in Multiple Myeloma

P. Croucher, M. McDonald, O. Charlat, 2023, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Bortezomib Reduces Serum Dickkopf-1 and RANKL Concentrations and Normalizes Indices of Bone Remodeling in Patients with Relapsed Multiple Myeloma.

M. Dimopoulos, D. Heath, P. Croucher, 2006 .

Bone Turnover Markers and Prostate Cancer: Not Just a Measure of Bone Disease?

N. Corcoran, P. Croucher, M. Rogers, 2015, European urology.

Geranylgeranyl transferase type II inhibition prevents myeloma bone disease.

Les Coulton, Karin Vanderkerken, P. Croucher, 2008, Biochemical and biophysical research communications.

Signaling Between Tumor Cells and the Host Bone Marrow Microenvironment

P. Croucher, M. McDonald, N. Kovacic, 2013, Calcified Tissue International.

Apomine™, an inhibitor of HMG‐CoA‐reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo

P. Croucher, R. Russell, K. Vanderkerken, 2007, International journal of cancer.

The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer

I. Holen, P. Croucher, Ning Wang, 2015, Journal of experimental & clinical cancer research : CR.

Abstract PD07-08: Zoledronic acid specifically inhibits development of bone metastases in the post-menopausal setting – evidence from an in vivo breast cancer model

I. Holen, P. Croucher, Ning Wang, 2012 .

The effect of diet-induced weight loss on total body bone mass

P. Croucher, J. Compston, A. Coxon, 1992 .

A mouse model of early-onset renal failure, tertiary hyperparathyroidism and renal osteodystrophy

M. Brown, R. Cox, O. Devuyst, 2010 .

Serum osteoprotegerin (OPG) levels are associated with disease progression and response to androgen ablation in patients with prostate cancer

F. Hamdy, I. Holen, P. Croucher, 2004, The Prostate.

Sostdc1: A soluble BMP and Wnt antagonist that is induced by the interaction between myeloma cells and osteoblast lineage cells

P. Croucher, C. Eaton, M. Lawson, 2019, Bone.

Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation

P. Tam, P. Croucher, P. Baldock, 2017, Calcified Tissue International.

A niche

I. Amit, K. Vandyke, D. Hose, 2004 .

Zoledronic acid prevents the development of osteolytic bone disease and increases survival in a murine model of multiple myeloma

P. Croucher, E. Marck, K. Vanderkerken, 2002 .

ENTRAIN: integrating trajectory inference and gene regulatory networks with spatial data to co-localize the receptor-ligand interactions that specify cell fate

Leonard D. Goldstein, T. Phan, P. Croucher, 2023, bioRxiv.

The RANKL system and the development of tumor-induced bone disease: lessons from pre-clinical models.

P. Croucher, P. Croucher, 2004, Journal of musculoskeletal & neuronal interactions.

A trans-eQTL network regulates osteoclast multinucleation and bone mass

E. Petretto, Kwon-Sik Park, M. Rotival, 2020, bioRxiv.

P3. A soluble activin type II receptor prevents the development of myeloma bone disease

D. Heath, P. Croucher, J. Seehra, 2008 .

Human myeloma cells promote the production of interleukin 6 by primary human osteoblasts

Apperley, Russell, P. Croucher, 2000, British journal of haematology.

Evidence for interrupted bone resorption in human iliac cancellous bone

W. Gilks, P. Croucher, J. Compston, 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Targeting RANK/RANKL in the treatment of solid tumours and myeloma.

P. Croucher, M. Lawson, H. Neville-Webbe, 2010, Current pharmaceutical design.

Comparison between the lengths of individual osteoid seams and resorption cavities in human iliac crest cancellous bone.

P. Croucher, J. Compston, K. Yamaguchi, 1993, Bone and mineral.

The Effect of Myeloma Cells on Bone Homeostasis Is Heterogenous and Correlates with Underlying Genetic Lesions and Bone Disease In Vivo

P. Croucher, K. Yong, D. Lath, 2010 .

Inhibiting activin‐A signaling stimulates bone formation and prevents cancer‐induced bone destruction in vivo

M. Bouxsein, P. Croucher, T. Arnett, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation

P. Tam, P. Croucher, P. Baldock, 2017, Calcified Tissue International.

Inhibiting Dickkopf‐1 (Dkk1) Removes Suppression of Bone Formation and Prevents the Development of Osteolytic Bone Disease in Multiple Myeloma

J. Shaughnessy, D. Heath, J. Snowden, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Prostate Cancer Cells Preferentially Home to Osteoblast‐rich Areas in the Early Stages of Bone Metastasis: Evidence From In Vivo Models

I. Holen, P. Croucher, Ning Wang, 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

the 23 and Me Research Team, ... M. (2018). An atlas of genetic influences on osteoporosis in humans and mice. Nature Genetics

C. Lelliott, F. Rivadeneira, J. Kemp, 2018 .

Genome-wide association study of extreme high bone mass: Contribution of common genetic variation to extreme BMD phenotypes and potential novel BMD-associated genes

M. Brown, M. Marshall, J. Kemp, 2018, Bone.

Metastasis and bone loss: advancing treatment and prevention.

I. Holen, L. Suva, P. Croucher, 2010, Cancer Treatment Reviews.

Minimally invasive longitudinal intravital imaging of cellular dynamics in intact long bone

T. Phan, P. Croucher, Wunna Kyaw, 2023, Nature Protocols.

Bone metastases

A. Padhani, M. Fallon, P. Croucher, 2020, Nature Reviews Disease Primers.

A. Boyde, R. Cox, P. Croucher, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to a Col2a1 mutation

M. Brown, A. Boyde, R. Cox, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.