Sangwon Lee

发表

NMR and mutagenesis of human copper transporter 1 (hCtr1) show that Cys-189 is required for correct folding and dimerization.

Sangwon Lee, S. Howell, S. Opella, 2007, Biochimica et biophysica acta.

Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling

E. Pardon, J. Steyaert, I. Lax, 2018, Nature.

Inhibition of ErbB3 by a monoclonal antibody that locks the extracellular domain in an inactive configuration

J. Schlessinger, Sangwon Lee, Joseph Amick, 2015, Proceedings of the National Academy of Sciences.

Dipolar waves map the structure and topology of helices in membrane proteins.

G. Veglia, Sangwon Lee, S. Opella, 2003, Journal of the American Chemical Society.

Design of protein-binding proteins from the target structure alone

Samer F. Halabiya, H. Ruohola-Baker, S. Savvides, 2022, Nature.

The E2 domains of APP and APLP1 share a conserved mode of dimerization.

Yongcheng Wang, Sangwon Lee, Y. Ha, 2011, Biochemistry.

Cryo-EM analyses of wild-type and oncogenic KIT mutants reveal structural oncogenic plasticity and a novel “Achilles heel” for therapeutic intervention

I. Lax, J. Schlessinger, Sangwon Lee, 2022, bioRxiv.

Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication

Sangwon Lee, Y. Ha, A. Fürstner, 2017, Scientific Reports.

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis

G. Shulman, J. Schlessinger, Sangwon Lee, 2015, Nature Communications.

Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein

D. Baker, J. Schlessinger, Sangwon Lee, 2022, Cell reports.

Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity

A. Schlessinger, E. Pardon, J. Steyaert, 2019, Proceedings of the National Academy of Sciences.

Robust de novo design of protein binding proteins from target structural information alone

D. Baker, K. Garcia, I. Wilson, 2021, bioRxiv.

Carboxyl‐terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity

Y. Suh, Sangwon Lee, J. Rah, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Crystal Structure of the E2 Domain of Amyloid Precursor Protein-like Protein 1 in Complex with Sucrose Octasulfate*

Yongcheng Wang, Sangwon Lee, Y. Ha, 2011, The Journal of Biological Chemistry.

Backbone structure of a small helical integral membrane protein: A unique structural characterization

Sangwon Lee, S. Opella, T. Cross, 2008, Protein science : a publication of the Protein Society.

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

J. Shendure, H. Ruohola-Baker, L. Carter, 2023, bioRxiv.

The crystal structure of GXGD membrane protease FlaK

Sangwon Lee, Y. Ha, Jian Hu, 2011, Nature.

FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho

I. Lax, J. Schlessinger, Yoshihisa Suzuki, 2020, Proceedings of the National Academy of Sciences.

FGF-21 Conducts a Liver-Brain-Kidney Axis to Promote Renal Cell Carcinoma

Sangwon Lee, D. Braun, Wanling Zhu, 2023, bioRxiv.

Functional characterization and NMR spectroscopy on full-length Vpu from HIV-1 prepared by total chemical synthesis.

G. Kochendoerfer, Sangwon Lee, S. Opella, 2004, Journal of the American Chemical Society.

Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization

Sangwon Lee, Y. Ha, Yi Xue, 2011, Proceedings of the National Academy of Sciences.

Structure and Function of Vpu from HIV-1

Sangwon Lee, S. Opella, M. Montal, 2005 .

Crystal structure of the E2 domain of amyloid precursor protein-like protein 1 in complex with sucrose octasulfate.

Yongcheng Wang, Sangwon Lee, Y. Ha, 2013, The Journal of Biological Chemistry.

Comprehensive evaluation of solution nuclear magnetic resonance spectroscopy sample preparation for helical integral membrane proteins

Hau B. Nguyen, C. Sanders, Sangwon Lee, 2006, Journal of Structural and Functional Genomics.

Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention

I. Lax, J. Schlessinger, Sangwon Lee, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Solution structure of neuromedin B by 1H nuclear magnetic resonance spectroscopy

Sangwon Lee, Y. Kim, 1999, FEBS letters.