S. Bremer

发表

3.11. Reproductive and Developmental Toxicity

George Daston, Horst Spielmann, Susanne Bremer, 2005, Alternatives to laboratory animals : ATLA.

Effects of Embryotoxic Chemicals on the In vitro Differentiation of Genetically Engineered Embryonic Stem Cells into Cardiac Cells.

B. Fleischmann, S. Bremer, M. Paparella, 1999, Toxicology in vitro : an international journal published in association with BIBRA.

Establishment of an Embryotoxicity Assay with Green Fluorescence Protein-expressing Embryonic Cell-derived Cardiomyocytes

B. Fleischmann, S. Bremer, M. Paparella, 1999, Alternatives to laboratory animals : ATLA.

Fabrication and characterization of protein arrays for stem cell patterning

F. Rossi, S. Bremer, P. Colpo, 2009 .

A Modular Approach to the ECVAM Principles on Test Validity

Valérie Zuang, Andrew Worth, Silvia Casati, 2004, Alternatives to laboratory animals : ATLA.

Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

Valérie Zuang, George Loizou, Andrew Worth, 2011, Archives of Toxicology.

The ReProTect Feasibility Study, a novel comprehensive in vitro approach to detect reproductive toxicants.

Hilda Witters, Aldert Piersma, Marc Weimer, 2010, Reproductive toxicology.

Weak estrogenic transcriptional activities of Bisphenol A and Bisphenol S.

S. Bremer, E. Grignard, S. Lapenna, 2012, Toxicology in vitro : an international journal published in association with BIBRA.

Development of an in vitro test battery for assessing chemical effects on bovine germ cells under the ReProTect umbrella.

S. Bremer, I. Tessaro, S. Hoffmann, 2008, Toxicology and applied pharmacology.

Transferability and inter-laboratory variability assessment of the in vitro bovine oocyte maturation (IVM) test within ReProTect.

S. Bremer, C. Galli, G. Lazzari, 2010, Reproductive toxicology.

The test chemical selection procedure of the European Centre for the Validation of Alternative Methods for the EU Project ReProTect.

S. Bremer, C. Pellizzer, P. Pazos, 2010, Reproductive toxicology.

ReProGlo: a new stem cell-based reporter assay aimed to predict embryotoxic potential of drugs and chemicals.

M. Schwarz, S. Bremer, C. Koehle, 2010, Reproductive toxicology.

Overview of the blood compatibility of nanomedicines: A trend analysis of in vitro and in vivo studies

S. Bremer, N. Liptrott, P. Urban, 2018, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

hESC Technology for Toxicology and Drug Development: Summary of Current Status and Recommendations for Best Practice and Standardization The Report and Recommendations of and ECVAM Workshop.

J. Trosko, T. Hartung, C. Mandenius, 2007 .

The possible impact of human embryonic stem cells on safety pharmacological and toxicological assessments in drug discovery and drug development.

S. Bremer, T. Stummann, 2008, Current stem cell research & therapy.

The Detection of Differentiation-inducing Chemicals by using Green Fluorescent Protein Expression in Genetically Engineered Teratocarcinoma Cells

T. Hartung, S. Bremer, M. Paparella, 2005, Alternatives to laboratory animals : ATLA.

Digital movie analysis for quantification of beating frequencies, chronotropic effects, and beating areas in cardiomyocyte cultures.

S. Bremer, M. Whelan, T. Sobanski, 2008, Assay and drug development technologies.

Selective targeting of human lymphokine-activated killer cells by CD3 monoclonal antibody against the interferon-inducible high-affinity Fc gamma RI receptor (CD64) on autologous acute myeloid leukemic blast cells.

E. Thiel, W. Ludwig, S. Bremer, 1993, Blood.

Alternative (non-animal) methods for chemicals testing: Current status and future prospects - Overview

Valérie Zuang, Silvia Casati, Andrew P. Worth, 2002 .

Development of a Testing Strategy for Detecting Embryotoxic Hazards of Chemicals In Vitro by using Embryonic Stem Cell Models

S. Bremer, M. Paparella, S. Adler, 2002, Alternatives to laboratory animals : ATLA.

Assessment of acute and chronic toxicity of doxorubicin in human induced pluripotent stem cell-derived cardiomyocytes.

S. Bremer, F. Pistollato, P. Macko, 2017, Toxicology in vitro : an international journal published in association with BIBRA.

The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy.

Karl-Heinz Krause, Michel Puceat, Marcel Leist, 2008, ALTEX.

Embryotoxicity hazard assessment of cadmium and arsenic compounds using embryonic stem cells.

S. Bremer, T.C. Stummann, L. Hareng, 2008, Toxicology.

The integrated project ReProTect: a novel approach in reproductive toxicity hazard assessment.

Michael Schwarz, Thomas Hartung, Lars Hareng, 2005, Reproductive toxicology.

The Effects of Chemicals on Mammalian Fertility

George Daston, Donatella Balduzzi, Susanne Bremer, 2005, Alternatives to laboratory animals : ATLA.

A Review of the Implementation of the Embryonic Stem Cell Test (EST)

Aldert Piersma, Vera Rogiers, Horst Spielmann, 2009, Alternatives to laboratory animals : ATLA.

First steps in establishing a developmental toxicity test method based on human embryonic stem cells.

T. Hartung, S. Bremer, S. Adler, 2008, Toxicology in vitro : an international journal published in association with BIBRA.

Validation of the Embryonic Stem Cell Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests

Susanne Bremer, Elke Genschow, Andrea Seiler, 2004, Alternatives to laboratory animals : ATLA.

The ECVAM International Validation Study on In Vitro Embryotoxicity Tests: Results of the Definitive Phase and Evaluation of Prediction Models

Aldert Piersma, Susanne Bremer, Hannele Huuskonen, 2002, Alternatives to laboratory animals : ATLA.

In vitro germ cell models for the detection of fertility impairment

S. Bremer, R. Vogel, A. Domke, 2000, Andrologia.

Pluripotent stem cells of the mouse as a potential in vitro model for mammalian germ cells. Sister chromatid exchanges induced by MMC and ENU in undifferentiated cell lines compared to differentiated cell lines.

S. Bremer, R. Vogel, 1999, Mutation research.

The effects of solvents on embryonic stem cell differentiation.

T Hartung, T. Hartung, S. Bremer, 2006, Toxicology in vitro : an international journal published in association with BIBRA.

The use of embryonic stem cells for regulatory developmental toxicity testing in vitro--the current status of test development.

T Hartung, T. Hartung, S. Bremer, 2004, Current pharmaceutical design.

Prevalidation of the Embryonic Stem Cell Test (EST)-A New In Vitro Embryotoxicity Test.

H Raabe, S. Bremer, M. Paparella, 1999, Toxicology in vitro : an international journal published in association with BIBRA.

Embryotoxicity hazard assessment of methylmercury and chromium using embryonic stem cells.

S. Bremer, S Bremer, L Hareng, 2007, Toxicology.

Cardiotoxicity testing using pluripotent stem cell‐derived human cardiomyocytes and state‐of‐the‐art bioanalytics: a review

Carl-Fredrik Mandenius, Elmar Heinzle, Susanne Bremer, 2011, Journal of applied toxicology : JAT.

Challenges of using pluripotent stem cells for safety assessments of substances.

S. Bremer, K. Vojnits, 2010, Toxicology.

Metabolism: A Bottleneck in In Vitro Toxicological Test Development

Andrew Worth, Silvia Casati, Raffaella Corvi, 2006, Alternatives to laboratory animals : ATLA.

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

Hedi Peterson, Daniel Gerhard, Raivo Kolde, 2012, Archives of Toxicology.

Hazard assessment of methylmercury toxicity to neuronal induction in embryogenesis using human embryonic stem cells.

S. Bremer, T. Stummann, L. Hareng, 2009, Toxicology.

Establishment of an in vitro reporter gene assay for developmental cardiac toxicity.

B. Fleischmann, S. Bremer, M. Paparella, 2001, Toxicology in vitro : an international journal published in association with BIBRA.

Guidance on classification for reproductive toxicity under the globally harmonized system of classification and labelling of chemicals (GHS)

S. Bremer, R. H. Mckee, N. Hallmark, 2013, Critical reviews in toxicology.

ECVAM and new technologies for toxicity testing.

Valérie Zuang, Silvia Casati, Raffaella Corvi, 2012, Advances in experimental medicine and biology.

Developmental toxicity testing from animal towards embryonic stem cells.

Thomas Hartung, Cristian Pellizzer, Susanne Bremer, 2005, ALTEX.

Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment

James K. Ellis, J. Hengstler, H. Keun, 2015, Archives of Toxicology.

Development of an in vitro embryotoxicity test using murine embryonic stem cell cultures.

S. Bremer, H. Spielmann, I. Pohl, 1993, Toxicology in vitro : an international journal published in association with BIBRA.

The use of quantitative image analysis in the assessment of in vitro embryotoxicity endpoints based on a novel embryonic stem cell clone with endoderm-related GFP expression.

B. Fleischmann, S. Bremer, J. Hescheler, 2002, Toxicology in vitro : an international journal published in association with BIBRA.

Preliminary Results of the ECVAM Validation Study on Three In Vitro Embryotoxicity Tests

A. Piersma, S. Bremer, H. Spielmann, 2001, Alternatives to laboratory animals : ATLA.

The Practical Application of Three Validated In Vitro Embryotoxicity Tests

Aldert Piersma, Thomas Hartung, Horst Spielmann, 2006, Alternatives to laboratory animals : ATLA.

Development of prediction models for three in vitro embryotoxicity tests in an ECVAM validation study.

A. Piersma, S. Bremer, F. Paillard, 2000, In vitro & molecular toxicology.

[Results of the first phase of the ECVAM project "prevalidation and validation of three in vitro embryotoxicity tests"]

A. Piersma, H. Holzhütter, S. Bremer, 1998, ALTEX.

Optimization and prevalidation of the in vitro ERalpha CALUX method to test estrogenic and antiestrogenic activity of compounds.

Juliette Legler, Hilda Witters, Annette Kopp-Schneider, 2010, Reproductive toxicology.

Report and Recommendations of the Workshop of the European Centre for the Validation of Alternative Methods for Drug-Induced Cardiotoxicity

Carl-Fredrik Mandenius, Mario Beilmann, Susanne Bremer, 2009, Cardiovascular Toxicology.

The Relative Semi-quantification of mRNA Expression as a Useful Toxicological Endpoint for the Identification of Embryotoxic/Teratogenic Substances.

R Clothier, S. Bremer, G. Archer, 1999, Toxicology in vitro : an international journal published in association with BIBRA.

Monitoring of teratogenic effects in vitro by analysing a selected gene expression pattern.

T. Hartung, S. Bremer, R. Corvi, 2004, Toxicology in vitro : an international journal published in association with BIBRA.

In Vitro Tests for Detecting Chemicals Affecting the Embryo Implantation Process

Michael Schwarz, Cristian Pellizzer, Susanne Bremer, 2007, Alternatives to laboratory animals : ATLA.

A comparative transcriptomic study on the effects of valproic acid on two different hESCs lines in a neural teratogenicity test system.

S. Bremer, K. Meganathan, J. Hescheler, 2014, Toxicology letters.

The value of alternative testing for neurotoxicity in the context of regulatory needs.

Thomas Hartung, Chantra Eskes, Erwin van Vliet, 2006, Environmental toxicology and pharmacology.

Test systems of developmental toxicity: state-of-the art and future perspectives

Raivo Kolde, Jan G. Hengstler, Karl-Heinz Krause, 2013, Archives of Toxicology.

The Principles of Weight of Evidence Validation of Test Methods and Testing Strategies

Valérie Zuang, Silvia Casati, Raffaella Corvi, 2006, Alternatives to laboratory animals : ATLA.

Regenerative toxicology: the role of stem cells in the development of chronic toxicities

S. Bremer, F. Pistollato, J. Louisse, 2014, Expert opinion on drug metabolism & toxicology.

ECVAM's Response to the Changing Political Environment for Alternatives: Consequences of the European Union Chemicals and Cosmetics Policies

Andrew Worth, Silvia Casati, Raffaella Corvi, 2003, Alternatives to laboratory animals : ATLA.

A Modular Approach to the Extended One-generation Reproduction Toxicity Study

Thomas Hartung, Matt Dent, George Daston, 2009, Alternatives to laboratory animals : ATLA.

The development of new concepts for assessing reproductive toxicity applicable to large scale toxicological programmes.

T Seidle, T Hartung, T. Hartung, 2007, Current pharmaceutical design.

Test systems of developmental toxicity: state-of-the art and future perspectives

R. Kolde, K. Krause, J. Rahnenführer, 2013, Archives of Toxicology.

The assessment of estrogenic or anti-estrogenic activity of chemicals by the human stably transfected estrogen sensitive MELN cell line: results of test performance and transferability.

S. Bremer, H. Witters, M. Weimer, 2010, Reproductive toxicology.

Detection of tissue-specific effects by methotrexate on differentiating mouse embryonic stem cells.

T. Hartung, S. Bremer, S. Adler, 2004, Birth defects research. Part B, Developmental and reproductive toxicology.

Report of the EPAA–ECVAM Workshop on the Validation of Integrated Testing Strategies (ITS)

Valérie Zuang, Andrew Worth, Silvia Casati, 2012, Alternatives to laboratory animals : ATLA.

Embryonic stem cells in safety pharmacology and toxicology.

Susanne Bremer, S. Bremer, Tina C Stummann, 2012, Advances in experimental medicine and biology.

Detection of the Embryotoxic Potential of Cyclophosphamide by Using a Combined System of Metabolic Competent Cells and Embryonic Stem Cells

S. Bremer, M. Paparella, S. Coecke, 2002, Alternatives to laboratory animals : ATLA.

The development of new concepts for assessing reproductive toxicity applicable to large scale toxicological programmes.

T. Hartung, S. Bremer, T. Seidle, 2007, Current pharmaceutical design.

Degeneration of the compound eye of the termite Neotermes jouteli (Isoptera) in darkness during the phase of reproduction

H. Hertel, S. Bremer, E. Wachmann, 1993, Zoomorphology.

Weak estrogenic transcriptional activities of Bisphenol A and Bisphenol S.

S. Bremer, E. Grignard, S. Lapenna, 2012, Toxicology in vitro : an international journal published in association with BIBRA.