D. Prockop

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Adipogenic Differentiation of Human Adult Stem Cells From Bone Marrow Stroma (MSCs)

I. Sekiya, J. Vuoristo, B. Larson, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice

Darwin J. Prockop, D. Prockop, R. H. Lee, 2006, Proceedings of the National Academy of Sciences.

Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation.

D. Prockop, Joo Youn Oh, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Detection and location of single-base mutations in large DNA fragments by immunomicroscopy.

D. Prockop, A. Ganguly, J. E. Rooney, 1989, Genomics.

Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta.

W. Koo, R. Pyeritz, D. Prockop, 2001, Blood.

Partial purification of a procollagen C-proteinase. Inhibition by synthetic peptides and sequential cleavage of type I procollagen.

D. Prockop, F. K. Njieha, T. Morikawa, 1982, Biochemistry.

The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1.

A. Sieron, D. Prockop, A. Fertala, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Stanniocalcin-1 attenuates ischemic cardiac injury and response of differentiating monocytes/macrophages to inflammatory stimuli.

D. Prockop, R. H. Lee, Arezoo Mohammadipoor, 2016, Translational research : the journal of laboratory and clinical medicine.

Review: ex vivo engineering of living tissues with adult stem cells.

D. Prockop, D. Phinney, Bonnie L. Barrilleaux, 2006, Tissue engineering.

Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues

D. Prockop, 1997, Science.

A simple and efficient enzymatic method for covalent attachment of DNA to cellulose. Application for hybridization-restriction analysis and for in vitro synthesis of DNA probes.

D. Prockop, T. Goldkorn, 1986, Nucleic acids research.

Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains.

D J Prockop, G. Kopen, D. Prockop, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses

A. P. Robinson, D. Prockop, S. Shioda, 2008, Proceedings of the National Academy of Sciences.

Identical G+1 to A mutations in three different introns of the type III procollagen gene (COL3A1) produce different patterns of RNA splicing in three variants of Ehlers-Danlos syndrome. IV. An explanation for exon skipping some mutations and not others.

H. Kuivaniemi, G. Tromp, D. Prockop, 1990, The Journal of biological chemistry.

A mutation in the pro alpha 2(I) gene (COL1A2) for type I procollagen in Ehlers-Danlos syndrome type VII: evidence suggesting that skipping of exon 6 in RNA splicing may be a common cause of the phenotype.

R. Weksberg, H. Kuivaniemi, G. Tromp, 1991, American journal of human genetics.

Concise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair—Current Views

D. Prockop, D. Phinney, Donald G. Phinney, 2007, Stem cells.

Modifications of a specific assay for hydroxyproline in urine.

K. Kivirikko, D. Prockop, O. Laitinen, 1967, Analytical biochemistry.

Consortium for osteogenesis imperfecta mutations in the helical domain of type I collagen: regions rich in lethal mutations align with collagen binding sites for integrins and proteoglycans

F. Glorieux, P. Byers, J. Troendle, 2007, Human mutation.

Adult rat and human bone marrow stromal cells differentiate into neurons

I. Black, D. Prockop, D. Woodbury, 2000, Journal of neuroscience research.

Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model

D. Prockop, Chi-Chao Chan, J. Oh, 2012, Journal of Neuroinflammation.

Effects of the stereo-configuration of the hydroxyl group in 4-hydroxyproline on the triple-helical structures formed by homogenous peptides resembling collagen.

D. Prockop, K. Inouye, S. Sakakibara, 1976, Biochimica et biophysica acta.

Collagen II containing a Cys substitution for Arg-alpha1-519. Analysis by atomic force microscopy demonstrates that mutated monomers alter the topography of the surface of collagen II fibrils.

D. Prockop, A. Fertala, S. Yamashina, 1999, Matrix biology : journal of the International Society for Matrix Biology.

Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs)

D. Prockop, M. Ullah, T. Bartosh, 2016, Proceedings of the National Academy of Sciences.

Regulating in Vitro Motility of Human Mesenchymal Stem Cells with Macrophage Migration Inhibitory Factor (MIF) and a Small-Molecule MIF Antagonist

Katie C. Russell, D. Prockop, D. Phinney, 2012 .

Premature Vertebral Endplate Ossification and Mild Disc Degeneration in Mice After Inactivation of One Allele Belonging to the Col2a1 Gene for Type II Collagen

M. Hyttinen, H. Helminen, D. Prockop, 2001, Spine.

An official American Thoracic Society workshop report: stem cells and cell therapies in lung biology and diseases.

D. Prockop, P. Lelkes, D. Kotton, 2015, Annals of the American Thoracic Society.

The thermal transition of a non-hydroxylated form of collagen. Evidence for a role for hydroxyproline in stabilizing the triple-helix of collagen.

R A Berg, D J Prockop, D. Prockop, 1973, Biochemical and biophysical research communications.

Isolation of unhydroxylated type I procollagen folding of the protein in vitro.

D. Prockop, P. Bruckner, T. Hayashi, 1981, Archives of biochemistry and biophysics.

Hydroxylation of (Pro-Pro-Gly)5 and (Pro-Pro-Gly)10 by prolyl hydroxylase. Evidence for an asymmetric active site in the enzyme.

D. Prockop, S. Sakakibara, R. Berg, 1977, Biochemistry.

Primary and secondary effects of ascorbate on procollagen synthesis and protein synthesis by primary cultures of tendon fibroblasts.

W. Kao, D. Prockop, J. Flaks, 1976, Archives of biochemistry and biophysics.

Synthesis of elastin and procallagen by cells from embryonic aorta. Differences in the role of hydroxyproline and the effects of proline analogs on the secretion of the two proteins.

J. Uitto, D. Prockop, Hoffmann H-P, 1976, Archives of biochemistry and biophysics.

Prolyl hydroxylase activity in L-929 fibroblasts incubated with and without ascorbate

W. Kao, D. Prockop, R. Berg, 1976 .

Retention of nonhelical procollagen containing cis-hydroxyproline in rough endoplasmic reticulum

J. Uitto, D. Prockop, H. Hoffman, 1975, Science.

Further characterization of embryonic tendon fibroblasts and the use of immunoferritin techniques to study collagen biosynthesis

B. Olsen, D. Prockop, R. Berg, 1975, The Journal of cell biology.

Hydroxylation of peptide-bound proline and lysine before and after chain completion of the polypeptide chains of procollagen.

J. Uitto, D. Prockop, 1974, Archives of biochemistry and biophysics.

Synthesis and secretion of under-hydroxylated procollagen at various temperatures by cells subject to temporary anoxia.

J. Uitto, D. Prockop, 1974, Biochemical and Biophysical Research Communications - BBRC.

Intracellular hydroxylation of non-helical protocollagen to form triple-helical procollagen and subsequent secretion of the molecule.

J. Uitto, D. Prockop, 1974, European journal of biochemistry.

Incorporation of proline analogues into collagen polypeptides Effects on the production of extracellular procollagen and on the stability of the triple-helical structure of the molecule☆

J. Uitto, D. Prockop, 1974 .

A model for the triple-helical structure of (Pro-Hyp-Gly)10 involving a cis peptide bond and inter-chain hydrogen-bonding to the hydroxyl group of hydroxyproline.

D. Prockop, K. Inouye, A. Tonelli, 1973, Biochimica et biophysica acta.

Rate of helix formation by intracellular procollagen and protocollagen. Evidence for a role for disulfide bonds.

J. Uitto, D. Prockop, 1973, Biochemical and biophysical research communications.

The biosynthesis of collagen. 1.

D. Prockop, M. E. Grant, Darwin J. Prockop, 1972, The New England journal of medicine.

Adult stem cells from bone marrow stroma differentiate into airway epithelial cells: potential therapy for cystic fibrosis.

D. Prockop, J. Kolls, V. Valentine, 2005, Proceedings of the National Academy of Sciences of the United States of America.

MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs

Eoin P. McNeill, D. Prockop, R. H. Lee, 2014, Proceedings of the National Academy of Sciences.

Methods and protocols. Preface.

D. Prockop, B. Bunnell, D. Phinney, 2008, Methods in molecular biology.

Complete primary structure of the alpha 1-chain of human basement membrane (type IV) collagen.

D. Prockop, K. Tryggvason, R. Soininen, 1987, FEBS letters.

Complete primary structure of the α1‐chain of human basement membrane (type IV) collagen

D. Prockop, K. Tryggvason, T. Haka-Risku, 1987 .

Structural organization of the gene for the alpha 1 chain of human type IV collagen.

D. Prockop, K. Tryggvason, A. Ganguly, 1989, The Journal of biological chemistry.

Growing tips of type I collagen fibrils formed in vitro are near-paraboloidal in shape, implying a reciprocal relationship between accretion and diameter.

J. A. Chapman, K. Kadler, D. Prockop, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Pleomorphism in type I collagen fibrils produced by persistence of the procollagen N-propeptide.

J. A. Chapman, K. Kadler, A. Mould, 1989, Journal of molecular biology.

Adult stem cells gradually come of age

D. Prockop, 2002, Nature Biotechnology.

Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammation.

D. Prockop, J. Oh, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow.

D J Prockop, R. Class, D. Prockop, 2000, Proceedings of the National Academy of Sciences of the United States of America.

iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers

D. Prockop, R. Reger, J. Xu, 2017, Cell Death Discovery.

iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers

D. Prockop, R. Reger, J. Xu, 2017, Cell Death Discovery.

Inflammation, fibrosis, and modulation of the process by mesenchymal stem/stromal cells.

D. Prockop, 2016, Matrix biology : journal of the International Society for Matrix Biology.

Administration of TSG-6 improves memory after traumatic brain injury in mice

D. Prockop, A. Shetty, Jessica E. Foraker, 2013, Neurobiology of Disease.

Cross‐talk between human mesenchymal stem/progenitor cells (MSCs) and rat hippocampal slices in LPS‐stimulated cocultures: the MSCs are activated to secrete prostaglandin E2

D. Prockop, R. H. Lee, J. Oh, 2011, Journal of neurochemistry.

Human stem/progenitor cells from bone marrow enhance glial differentiation of rat neural stem cells: a role for transforming growth factor β and Notch signaling.

A. P. Robinson, D. Prockop, J. Ylostalo, 2011, Stem cells and development.

Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels

D. Prockop, R. H. Lee, J. Semon, 2010, Cell and Tissue Research.

Reversible commitment to differentiation by human multipotent stromal cells in single-cell-derived colonies.

D. Prockop, Joni H Ylöstalo, N. Bazhanov, 2008, Experimental hematology.

Mesenchymal Stem Cells

D. Prockop, B. Bunnell, D. Phinney, 2008, Methods in Molecular Biology™.

In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP.

I. Fischer, D. Prockop, W. Deng, 2001, Biochemical and biophysical research communications.

Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta.

R. Class, D. Prockop, R. Pereira, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Absence of Therapeutic Benefit of the Anti-Inflammatory Protein TSG-6 for Corneal Alkali Injury in a Rat Model

D. Prockop, R. Reger, J. Oh, 2019, Current eye research.

Procollagen Processing Control of Type I Collagen Fibril Assembly

J. A. Chapman, K. Kadler, A. Mould, 1989 .

Aggregation of a type I collagen precursor containing N-terminal propeptides.

D. Prockop, P. Bruckner, M. Miyahara, 1983, Collagen and related research.

An allele of COL9A2 associated with intervertebral disc disease.

J. Ott, O. Tervonen, L. Ala‐Kokko, 1999, Science.

Strategies for improving animal models for regenerative medicine.

G. Schatten, M. Emborg, D. Prockop, 2013, Cell stem cell.

The zipper-like folding of collagen triple helices and the effects of mutations that disrupt the zipper.

J. Engel, D. Prockop, J. Engel, 1991, Annual review of biophysics and biophysical chemistry.

Use of Differentiating Adult Stem Cells (Marrow Stromal Cells) to Identify New Downstream Target Genes for Transcription Factors

I. Sekiya, J. Vuoristo, R. Pochampally, 2006, Stem cells.

Complete sequence of the 23-kilobase human COL9A3 gene. Detection of Gly-X-Y triplet deletions that represent neutral variants.

J. Liu, L. Ala‐Kokko, M. Warman, 1999, The Journal of biological chemistry.

Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages.

D. Prockop, R. H. Lee, J. Oh, 2011, Blood.

Hydroxylation of Proline and the Intracellular Accumulation of a Polypeptide Precursor of Collagen

D. Prockop, G. Cooper, J. Lash, 1966, Science.

beta-Aminopropionitrile prevents bleomycin-induced pulmonary fibrosis in the hamster.

D. Prockop, N. Edelman, R. Berg, 1982, The American review of respiratory disease.

Structure of cDNA clones coding for human type II procollagen. The alpha 1(II) chain is more similar to the alpha 1(I) chain than two other alpha chains of fibrillar collagens.

S. Jimenez, C. Baldwin, D. Prockop, 1989, The Biochemical journal.

Helical model of nucleation and propagation to account for the growth of type I collagen fibrils from symmetrical pointed tips: a special example of self-assembly of rod-like monomers.

D. Prockop, R. Harrison, D. Silver, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Exclusion of mutations in the gene for type III collagen (COL3A1) as a common cause of intracranial aneurysms or cervical artery dissections

B. Baxter, B. Mokri, R. Ferrell, 1993, Neurology.

Oxygen-18 studies on the conversion of proline to collagen hydroxyproline.

S. Udenfriend, D. Prockop, A. Kaplan, 1963, Archives of biochemistry and biophysics.

Oxygen-18 studies on the conversion of proline to hydroxyproline.

S. Udenfriend, D. Prockop, A. Kaplan, 1962, Biochemical and biophysical research communications.

Internal deletion in a collagen gene in a perinatal lethal form of osteogenesis imperfecta

J. Hirsch, D. Prockop, Charlene J. Williams, 1983, Nature.

Inhibitors of collagen biosynthesis as a means of controlling scar formation in tendon injury.

D. Prockop, J. Lane, F. Bora, 1972, The Journal of bone and joint surgery. American volume.

Assembly of Type I Collagen Fibrils de Novo by the Specific Enzymic Cleavage of pC Collagen

D J Prockop, K. Kadler, D. Prockop, 1990, Annals of the New York Academy of Sciences.

Assembly of Collagen Fibrils de Novo from Soluble Precursors: Polymerization and Copolymerization of Procollagen, pN-Collagen, and Mutated Collagens

D. Prockop, D. Hulmes, 1994 .

A type I collagen with substitution of a cysteine for glycine-748 in the alpha 1(I) chain copolymerizes with normal type I collagen and can generate fractallike structures.

K. Kadler, D. Prockop, B. Vogel, 1991, Biochemistry.

Effects of Mutations that Change Primary Structure of Collagen on the Self-Assembly of the Protein into Fibrils

J. Engel, K. Kadler, D. Prockop, 1989 .

Type I procollagen carboxyl-terminal proteinase from chick embryo tendons. Purification and characterization.

D. Prockop, Y. Hojima, M. E. van der Rest, 1985, The Journal of biological chemistry.

Procollagen N-proteinase. Properties of the enzyme purified from chick embryo tendons.

D. Prockop, L. Tuderman, 1982, European journal of biochemistry.

Formation of collagen fibrils by enzymic cleavage of precursors of type I collagen in vitro.

D. Prockop, K. Tanzawa, F. K. Njieha, 1984, The Journal of biological chemistry.

Assembly of collagen fibrils de novo by cleavage of the type I pC-collagen with procollagen C-proteinase. Assay of critical concentration demonstrates that collagen self-assembly is a classical example of an entropy-driven process.

K. Kadler, D. Prockop, Y. Hojima, 1987, The Journal of biological chemistry.

Type I procollagen N-proteinase from chick embryo tendons. Purification of a new 500-kDa form of the enzyme and identification of the catalytically active polypeptides.

D. Prockop, Y. Hojima, M. E. van der Rest, 1989, The Journal of biological chemistry.

Assembly of type I collagen fibrils de novo. Between 37 and 41 degrees C the process is limited by micro-unfolding of monomers.

K. Kadler, D. Prockop, Y. Hojima, 1988, The Journal of biological chemistry.

Partial purification and characterization of a neutral protease which cleaves the N-terminal propeptides from procollagen.

K. Kivirikko, D. Prockop, L. Tuderman, 1978, Biochemistry.

Formation of collagen fibrils in vitro by cleavage of procollagen with procollagen proteinases.

D. Prockop, F. K. Njieha, M. Miyahara, 1982, The Journal of biological chemistry.

MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis

H. Lee, D. Prockop, R. H. Lee, 2017, Stem cell reports.

Action at a Distance: Systemically Administered Adult Stem/Progenitor Cells (MSCs) Reduce Inflammatory Damage to the Cornea Without Engraftment and Primarily by Secretion of TNF‐α Stimulated Gene/Protein 6

D. Prockop, R. H. Lee, R. H. Rosa, 2011, Stem cells.

Significance of urinary hydroxyproline in man.

A. Sjoerdsma, D. Prockop, 1961, The Journal of clinical investigation.

Data against a Common Assumption: Xenogeneic Mouse Models Can Be Used to Assay Suppression of Immunity by Human MSCs.

D. Prockop, R. H. Lee, J. Oh, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

Stem cells in the face: tooth regeneration and beyond.

J. Mao, D. Prockop, 2012, Cell stem cell.

Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome

K. Kain, W. Liles, D. Prockop, 2014, BMC Immunology.

Intra-articular injection of human mesenchymal stem cells (MSCs) promote rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen.

I. Sekiya, T. Muneta, D. Prockop, 2012, Osteoarthritis and cartilage.

Collagen synthesis and collagenase activity in dermal fibroblasts from patients with diabetes and digital sclerosis.

J. Uitto, D. Prockop, J. Seibold, 1985, The Journal of laboratory and clinical medicine.

Identification of the HSPB4/TLR2/NF-κB axis in macrophage as a therapeutic target for sterile inflammation of the cornea

E. Wawrousek, D. Prockop, J. Oh, 2012, EMBO molecular medicine.

A specific method for the analysis of hydroxyproline in tissues and urine.

S. Udenfriend, D. Prockop, 1960, Analytical biochemistry.

The Human COL11A2 Gene Structure Indicates that the Gene Has Not Evolved with the Genes for the Major Fibrillar Collagens (*)

L. Ala‐Kokko, D. Prockop, T. Pihlajamaa, 1995, The Journal of Biological Chemistry.

Mutation in a gene for type I procollagen (COL1A2) in a woman with postmenopausal osteoporosis: evidence for phenotypic and genotypic overlap with mild osteogenesis imperfecta.

B. Riggs, D. Prockop, A. Ganguly, 1991, Proceedings of the National Academy of Sciences of the United States of America.

CALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Phase-directed therapy: TSG-6 targeted to early inﬂammation improves bleomycin-injured lungs

D. Prockop, T. Bartosh, N. Bazhanov, 2013 .

A mutation in the gene for type III procollagen (COL3A1) in a family with aortic aneurysms.

H. Kuivaniemi, G. Tromp, D. Prockop, 1990, The Journal of clinical investigation.

Genetic causes of aortic aneurysms. Unlearning at least part of what the textbooks say.

H. Kuivaniemi, G. Tromp, D. Prockop, 1991, The Journal of clinical investigation.

Sequencing of cDNA from 50 unrelated patients reveals that mutations in the triple-helical domain of type III procollagen are an infrequent cause of aortic aneurysms.

G. Tromp, D. Prockop, W. Abbott, 1993, The Journal of clinical investigation.

Mutations in collagen genes: causes of rare and some common diseases in humans

H. Kuivaniemi, G. Tromp, D. Prockop, 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mutations in Collagen Genes as a Cause of Connective-Tissue Diseases

D. Prockop, 1992 .

Incorporation of 3,4-dehydroproline into protocollagen and collagen. Limited hydroxylation of proline and lysine in the same polypeptide.

J. Rosenbloom, D. Prockop, 1970, The Journal of biological chemistry.

Histamine Receptor H1 and Dermatopontin: New Downstream Targets of the Vitamin D Receptor

R. Pochampally, D. Prockop, J. Ylostalo, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Stanniocalcin-1 Regulates Extracellular ATP-Induced Calcium Waves in Human Epithelial Cancer Cells by Stimulating ATP Release from Bystander Cells

D. Prockop, Gregory J. Block, G. DiMattia, 2010, PloS one.

Location of xylosyltransferase in the cisternae of the rough endoplasmic reticulum of embryonic cartilage cells.

D. Prockop, N. Schwartz, L. Rodén, 1984, Connective tissue research.

Abnormal Response to Physical Activity in Femurs after Heterozygous Inactivation of One Allele of the Col2a1 Gene for Type II Collagen in Mice

M. Hyttinen, H. Helminen, J. Jurvelin, 2005, Calcified Tissue International.

Partial isodisomy for maternal chromosome 7 and short stature in an individual with a mutation at the COL1A2 locus.

D. Prockop, L. Spotila, L. Sereda, 1992, American journal of human genetics.

Amplification of Coronary Arteriogenic Capacity of Multipotent Stromal Cells by Epidermal Growth Factor

D. Prockop, W. Chilian, S. Belmadani, 2009, Arteriosclerosis, thrombosis, and vascular biology.

Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma

D. Prockop, Jeffrey L. Spees, S. Olson, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Potential use of stem cells from bone marrow to repair the extracellular matrix and the central nervous system.

G. Kopen, D. Prockop, D. Phinney, 2000, Biochemical Society transactions.

Angiogenic Effects of Human Multipotent Stromal Cell Conditioned Medium Activate the PI3K‐Akt Pathway in Hypoxic Endothelial Cells to Inhibit Apoptosis, Increase Survival, and Stimulate Angiogenesis

R. Pochampally, D. Prockop, S. Hung, 2007, Stem cells.

Effects of long-term diabetes and galactosaemia upon lens and retinal mRNA levels in the rat.

R. Poulsom, R. Boot-Handford, D. Prockop, 1990, Experimental eye research.

Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene.

W. Reardon, P. Byers, E. Petty, 1999, American journal of human genetics.

Prolyl 4-Hydroxylase from Human Placenta. Simultaneous Isolation of Immunoglobulin G which Binds to Ascaris Cuticle Collagen

B. Olsen, D. Prockop, A. Oronsky, 1982 .

Use of glutaraldehyde-fixed Escherichia coli cells as a convenient support for radioimmune assays.

D. Prockop, N. Guzman, W. Whei-Yang Kao, 1977, Analytical biochemistry.

Mutations that alter the primary structure of type I collagen. The perils of a system for generating large structures by the principle of nucleated growth.

D. Prockop, 1990, The Journal of biological chemistry.

Mesenchymal stem/stromal cells precondition lung monocytes/macrophages to produce tolerance against allo- and autoimmunity in the eye

H. Lee, D. Prockop, W. Wee, 2015, Proceedings of the National Academy of Sciences of the United States of America.

Intravenous mesenchymal stem cells prevented rejection of allogeneic corneal transplants by aborting the early inflammatory response.

H. Lee, D. Prockop, J. Oh, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Gene structure for the alpha 1 chain of a human short-chain collagen (type XIII) with alternatively spliced transcripts and translation termination codon at the 5' end of the last exon.

T. Pihlajaniemi, D. Prockop, K. Tryggvason, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Osteogenesis imperfecta: phenotypic heterogeneity, protein suicide, short and long collagen.

D. Prockop, 1984, American journal of human genetics.

Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury

D. Prockop, R. H. Rosa, J. Oh, 2010, Proceedings of the National Academy of Sciences.

ANTICONVULSANT PROPERTIES OF MONOAMINE OXIDASE INHIBITORS

B. Brodie, D. Prockop, P. A. Shore, 1959, Annals of the New York Academy of Sciences.

Adult stem cells, lung biology, and lung disease. NHLBI/Cystic Fibrosis Foundation Workshop.

M. A. Berberich, D. Gail, C. Penland, 2006, Proceedings of the American Thoracic Society.

Potential Use of Marrow Stromal Cells for Therapy of Osteogenesis Imperfecta and Osteoporosis

D. Prockop, 1997 .

Connective Tissue Biochemistry of Neurofibromas a

J. Uitto, T. Pihlajaniemi, D. Prockop, 1986, Annals of the New York Academy of Sciences.

Modulation of procollagen gene expression by retinoids. Inhibition of collagen production by retinoic acid accompanied by reduced type I procollagen messenger ribonucleic acid levels in human skin fibroblast cultures.

J. Uitto, D. Prockop, A. Oikarinen, 1985, The Journal of clinical investigation.

Presence of Translatable mRNA for Proα2(I) Chains in Fibroblasts from a Patient with Osteogenesis Imperfecta whose Type I Collagen does not Contain α2(I) Chains

D. Prockop, F. Pope, A. Nicholls, 1984 .

Formation of interchain disulfide bonds and helical structure during biosynthesis of procollagen by embryonic tendon cells.

J. Uitto, D. Prockop, J. Schofield, 1974, Biochemistry.

Self-assembly into fibrils of a homotrimer of type I collagen.

K. Kadler, D. Prockop, Y. Hojima, 1992, Matrix.

Increased steady-state levels of laminin B1 mRNA in kidneys of long-term streptozotocin-diabetic rats. No effect of an aldose reductase inhibitor.

R. Poulsom, R. Boot-Handford, D. Prockop, 1988, The Journal of biological chemistry.

Procedure I : Preparation of Fab-Ferritin or IgG-Ferritin with a Water-Soluble Carbodiimide and N-Hydroxysuccinimide

B. Olsen, D. Prockop, R. Berg, 2003 .

Type I procollagen: the gene-protein system that harbors most of the mutations causing osteogenesis imperfecta and probably more common heritable disorders of connective tissue.

H. Kuivaniemi, G. Tromp, K. Kadler, 1989, American journal of medical genetics.

Nuclease S1 mapping of a homozygous mutation in the carboxyl-propeptide-coding region of the pro alpha 2(I) collagen gene in a patient with osteogenesis imperfecta.

T. Pihlajaniemi, D. Prockop, J. Myers, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Assignment of the human pro alpha 2(I) collagen structural gene (COLIA2) to chromosome 7 by molecular hybridization.

M. Gross, C. Junien, D. Weil, 1982, American journal of human genetics.

Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension

J. Lasky, D. Prockop, Jeffrey L. Spees, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mutation analysis of coding sequences for type I procollagen in individuals with low bone density

T. Spector, E. Shane, D. Prockop, 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Modified procedure for the assay of H-3-or C-14-labeled hydroxyproline.

D. Prockop, K. Juva, 1966, Analytical biochemistry.

Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone.

H. Helminen, R. Fässler, D. Prockop, 1995, Genes & development.

Migratory response of mesenchymal stem cells to macrophage migration inhibitory factor and its antagonist as a function of colony-forming efficiency

Katie C. Russell, D. Prockop, D. Phinney, 2009, Biotechnology Letters.

Unique characteristics of human mesenchymal stromal/progenitor cells pre-activated in 3-dimensional cultures under different conditions.

D. Prockop, T. Bartosh, J. Ylostalo, 2014, Cytotherapy.

Analysis of the COL1A1 and COL1A2 genes by PCR amplification and scanning by conformation-sensitive gel electrophoresis identifies only COL1A1 mutations in 15 patients with osteogenesis imperfecta type I: identification of common sequences of null-allele mutations.

L. Ala‐Kokko, A. De Paepe, D. Prockop, 1998, American journal of human genetics.

Incorporation of proline analogs into procollagen. Assay for replacement of imino acids by cis-4-hydroxy-L-proline and cis-4-fluoro-L-proline.

J. Uitto, D. Prockop, 1977, Archives of biochemistry and biophysics.

Structure of protocollagen proline hydroxylase from chick embryos.

B. Olsen, D. Prockop, R. Berg, 1973, European journal of biochemistry.

The biosynthesis of basement membrane collagen in embryonic chick lens. I. Delay between the synthesis of polypeptide chains and the secretion of collagen by matrix-free cells.

D. Prockop, N. A. Kefalides, M. E. Grant, 1972, The Journal of biological chemistry.

Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo. I. Arrest of collagen accumulation in growing chick embryos.

D. Prockop, J. Lane, P. Dehm, 1971, Biochimica et biophysica acta.

Asymmetry in the hydroxylation of (Pro-Pro-Gly) 5 by protocollagen proline hydroxylase.

K. Kivirikko, D. Prockop, S. Sakakibara, 1971, Biochemical and biophysical research communications.

Protocollagen proline hydroxylase in normal liver and in hepatic fibrosis.

D. Prockop, T. Takeuchi, T. Takeuchi, 1969, Gastroenterology.

Identification of collagen in synovial fluid.

D. Mccarty, D. Prockop, K. Hummeler, 1969, Arthritis and rheumatism.

Biosynthesis of abnormal collagens with amino acid analogues. I. Incorporation of L-azetidine-2-carboxylic acid and cis-4-fluoro-L-proline into protocollagen and collagen.

D. Prockop, T. Takeuchi, 1969, Biochimica et biophysica acta.

Kinetic patterns of protocollagen hydroxylase and further studies on the polypeptide substrate.

K. Kivirikko, D. Prockop, H. Bright, 1968, Biochimica et biophysica acta.

Intraduodenal hydrolysis of gelatin as a measure of protein digestion in normal subjects and in patients with malabsorption syndromes.

D. Prockop, J. Cerda, F. Brooks, 1968, Gastroenterology.

Increased protocollagen hydroxylase activity in the livers of rats with hepatic fibrosis.

K. Kivirikko, D. Prockop, T. Takeuchi, 1967, Biochemical and biophysical research communications.

Relationship of Hydroxyproline Excretion in Urine to Collagen Metabolism: Biochemistry and Clinical Applications

K. Kivirikko, D. Prockop, 1967 .

A SIMPLE METHOD FOR DIFFERENTIAL ASSAY OF TRITIUM AND CARBON-14 IN WATER-SOLUBLE BIOLOGICAL MATERIALS.

D. Prockop, P. Ebert, 1963, Analytical biochemistry.

cDNA cloning and expression of bovine procollagen I N-proteinase: A new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components

A. Sieron, D. Prockop, A. Colige, 1997 .

Mutation in type II procollagen (COL2A1) that substitutes aspartate for glycine alpha 1-67 and that causes cataracts and retinal detachment: evidence for molecular heterogeneity in the Wagner syndrome and the Stickler syndrome (arthro-ophthalmopathy)

L. Ala‐Kokko, L. Haataja, K. Kivirikko, 1993, American journal of human genetics.

Transgenic mice with inactive alleles for procollagen N-proteinase (ADAMTS-2) develop fragile skin and male sterility.

M. Hyttinen, H. Helminen, G. Kopen, 2001, The Biochemical journal.

Pharmaceutical induction of ApoE secretion by multipotent mesenchymal stromal cells (MSCs)

D. Prockop, Suzanne Zeitouni, C. Gregory, 2008, BMC biotechnology.

Thermal stability of the triple helix of type I procollagen and collagen. Precautions for minimizing ultraviolet damage to proteins during circular dichroism studies.

D. Prockop, T. Hyashi, S. Curran-Patel, 1979, Biochemistry.

Preservation of Visual Function After Intraocular Transplantation of BDNF Secreting Mesenchymal Stem Cells in Glaucomatous Rat Eyes

Young H. Kwon, R. Kardon, D. Prockop, 2007 .

Human Multipotent Stromal Cells Undergo Sharp Transition from Division to Development in Culture

B. Larson, D. Prockop, Joni H. Ylöstalo, 2008, Stem cells.

“Stemness” Does Not Explain the Repair of Many Tissues by Mesenchymal Stem/Multipotent Stromal Cells (MSCs)

D. Prockop, D. Prockop, 2007, Clinical pharmacology and therapeutics.

Two new recurrent nucleotide mutations in the COL1A1 gene in four patients with osteogenesis imperfecta: About one‐fifth are recurrent

L. Ala‐Kokko, H. Kuivaniemi, G. Tromp, 1997, Human mutation.

Phenotypic variability and incomplete penetrance of spontaneous fractures in an inbred strain of transgenic mice expressing a mutated collagen gene (COL1A1).

B. Sokolov, D. Prockop, J. Khillan, 1994, The Journal of clinical investigation.

Defects in the processing of procollagen to collagen are demonstrable in cultured fibroblasts from patients with the Ehlers-Danlos and osteogenesis imperfecta syndromes.

D. Prockop, R. Minor, J. Berger, 1986, The Journal of biological chemistry.

Synthesis of an altered type III procollagen in a patient with type IV Ehlers-Danlos syndrome. A structural change in the alpha 1(III) chain which makes the protein more susceptible to proteinases.

R. Pyeritz, D. Prockop, C. Stolle, 1985, The Journal of biological chemistry.

Three new point mutations in type II procollagen (COL2A1) and identification of a fourth family with the COL2A1 Arg519-->Cys base substitution using conformation sensitive gel electrophoresis.

D. Prockop, M. Rock, R. Ladda, 1995, Human molecular genetics.

Prevention of collagen deposition following pulmonary oxygen toxicity in the rat by cis-4-hydroxy-L-proline.

D. Prockop, N. Edelman, R. Berg, 1980, The Journal of clinical investigation.

Gastrointestinal absorption and renal excretion of hydroxyproline peptides.

A. Sjoerdsma, D. Prockop, H. Keiser, 1962, Lancet.

Folding mechanism of the triple helix in type-III collagen and type-III pN-collagen. Role of disulfide bridges and peptide bond isomerization.

R. Timpl, J. Engel, D. Prockop, 1980, European journal of biochemistry.

Partial characterization of a low molecular weight human collagen that undergoes alternative splicing.

J. Seyer, T. Pihlajaniemi, D. Prockop, 1987, Proceedings of the National Academy of Sciences of the United States of America.

The genetic trail of osteoporosis.

D. Prockop, 1998, The New England journal of medicine.

More knee joint osteoarthritis (OA) in mice after inactivation of one allele of type II procollagen gene but less OA after lifelong voluntary wheel running exercise.

M. Hyttinen, H. Helminen, D. Prockop, 2001, Osteoarthritis and cartilage.

Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline.

D. Prockop, N. Edelman, R. Berg, 1981, The American review of respiratory disease.

Role of iron in the synthesis of collagen in connective tissue.

D. Prockop, 1971, Federation proceedings.

ISOTOPIC STUDIES ON COLLAGEN DEGRADATION AND THE URINE EXCRETION OF HYDROXYPROLINE.

D. Prockop, 1964, The Journal of clinical investigation.

Mesenchymal Stem/Stromal Cells Inhibit the NLRP3 Inflammasome by Decreasing Mitochondrial Reactive Oxygen Species

D. Prockop, W. Wee, J. Oh, 2014, Stem cells.

Genetic Linkage Analysis of Hereditary Arthro-Ophthalmopathy (Stickler Syndrome) and the Type 11 Procollagen Gene

S. Jimenez, J. Uitto, D. Prockop, 2006 .

Molecular heterogeneity in the mild autosomal dominant forms of osteogenesis imperfecta.

A. Børresen, D. Prockop, K. Berg, 1984, American journal of human genetics.

A second mutation in the type II procollagen gene (COL2AI) causing stickler syndrome (arthro-ophthalmopathy) is also a premature termination codon.

E. Zackai, D. Prockop, D. McDonald-McGinn, 1993, American journal of human genetics.

cDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components.

A. Sieron, D. Prockop, A. Colige, 1997, Proceedings of the National Academy of Sciences of the United States of America.

STAT6 induces expression of Gas6 in macrophages to clear apoptotic neutrophils and resolve inflammation

A. Malik, D. Prockop, Saroj Nepal, 2019, Proceedings of the National Academy of Sciences.

Further proof of the plasticity of adult stem cells and their role in tissue repair

D. Prockop, 2003, The Journal of cell biology.

Enzymatic hydroxylation of proline and lysine in protocollagen.

K. Kivirikko, D. Prockop, Darwin J. Prockop, 1967, Proceedings of the National Academy of Sciences of the United States of America.

Human Adipose‐Derived Stem Cells Ameliorate Cigarette Smoke‐Induced Murine Myelosuppression via Secretion of TSG‐6

H. Broxmeyer, I. Petrache, D. Prockop, 2015, Stem cells.

Temperature-induced post-translational over-modification of type I procollagen. Effects of over-modification of the protein on the rate of cleavage by procollagen N-proteinase and on self-assembly of collagen into fibrils.

D. Prockop, E. Adachi, Y. Hojima, 1992, The Journal of biological chemistry.

Anti-inflammatory protein tumor necrosis factor-α-stimulated protein 6 (TSG-6) promotes early gingival wound healing: an in vivo study.

D. Prockop, K. Svoboda, D. Kerns, 2015, Journal of periodontology.

Collagen Synthesis: Localization of Prolyl Hydroxylase in Tendon Cells Detected with Ferritin-Labeled Antibodies

D. Prockop, R. Berg, Y. Kishida, 1973, Science.

Targeted insertions of two exogenous collagen genes into both alleles of their endogenous loci in cultured human cells: the insertions are directed by relatively short fragments containing the promoters and the 5' ends of the genes.

A. Sieron, D. Prockop, R. Mewar, 1994, Proceedings of the National Academy of Sciences of the United States of America.

DIPHTHERIA TOXIN INHIBITS THE SYNTHESIS OF MYELIN PROTEOLIPID AND BASIC PROTEINS BY PERIPHERAL NERVE IN VITRO 1, 2

D. Pleasure, D. Prockop, D. Pleasure, 1973, Journal of neurochemistry.

Polymerization of pNcollagen I and copolymerization of pNcollagen I with collagen I. A kinetic, thermodynamic, and morphologic study.

J. Engel, D. Prockop, E. Adachi, 1992, The Journal of biological chemistry.

Multipotent Stromal Cells (MSCs) are Activated to Reduce Apoptosis in Part by Upregulation and Secretion of Stanniocalcin-1 (STC-1)

R. Pochampally, D. Prockop, C. Gregory, 2016 .

Phenotypic heterogeneity in osteogenesis imperfecta: the mildly affected mother of a proband with a lethal variant has the same mutation substituting cysteine for alpha 1-glycine 904 in a type I procollagen gene (COL1A1).

D. Prockop, C. Constantinou, S. Young, 1990, American journal of human genetics.

PCR detection of a HindIII polymorphism in the human gene for type II procollagen (COL2A1).

B. Sokolov, D. Prockop, T. Tsuneyoshi, 1991, Nucleic acids research.

Human COL9A1 and COL9A2 genes. Two genes of 90 and 15 kb code for similar polypeptides of the same collagen molecule.

L. Ala‐Kokko, D. Prockop, M. Perälä, 1998, Matrix biology : journal of the International Society for Matrix Biology.

Mutations in fibrillar collagens (types I, II, III, and XI), fibril‐associated collagen (type IX), and network‐forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels

H. Kuivaniemi, G. Tromp, D. Prockop, 1997, Human mutation.

Substitution of arginine for glycine at position 154 of the alpha 1 chain of type I collagen in a variant of osteogenesis imperfecta: comparison to previous cases with the same mutation.

H. Kuivaniemi, G. Tromp, D. Prockop, 1994, American journal of medical genetics.

Direct sequencing of PCR products derived from cDNAs for the proα1 and proα2 chains of type I procollagen as a screening method to detect mutations in patients with osteogenesis imperfecta

H. Kuivaniemi, G. Tromp, D. Prockop, 1996 .

Bone fragility in transgenic mice expressing a mutated gene for type I procollagen (COL1A1) parallels the age‐dependent phenotype of human osteogenesis imperfecta

D. Prockop, E. Hume, R. Pereira, 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Use of an automated workstation to facilitate PCR amplification, loading agarose gels and sequencing of DNA templates.

C. Baldwin, D. Prockop, D. Harrison, 1993, BioTechniques.

PvuII polymorphism at the COL1A2 locus.

D. Prockop, L. Spotila, C. Constantinou, 1990, Nucleic acids research.

A sequence polymorphism in the 3′-nontranslated region of the proα1 chain of type I procollagen

D. Prockop, C. Constantinou, A. Westerhausen, 1990 .

Substitution of serine for alpha 1(I)-glycine 844 in a severe variant of osteogenesis imperfecta minimally destabilizes the triple helix of type I procollagen. The effects of glycine substitutions on thermal stability are either position of amino acid specific.

D. Prockop, K. B. Nielsen, C. Constantinou, 1989, The Journal of biological chemistry.

Stanniocalcin-1 Rescued Photoreceptor Degeneration in Two Rat Models of Inherited Retinal Degeneration.

M. Lavail, D. Prockop, R. H. Rosa, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Influence of cortisol on the synthesis of sulfated mucopolysaccharides and collagen in chick embryos.

D. Prockop, P. Ebert, 1967, Biochimica et biophysica acta.

Substitution of aspartate for glycine 1018 in the type III procollagen (COL3A1) gene causes type IV Ehlers-Danlos syndrome: the mutated allele is present in most blood leukocytes of the asymptomatic and mosaic mother.

H. Kuivaniemi, G. Tromp, D. Prockop, 1992, American journal of human genetics.

Inheritance of an RNA splicing mutation (G+ 1 IVS20) in the type III procollagen gene (COL3A1) in a family having aortic aneurysms and easy bruisability: phenotypic overlap between familial arterial aneurysms and Ehlers-Danlos syndrome type IV.

H. Kuivaniemi, G. Tromp, D. Prockop, 1990, American journal of human genetics.

Apoptosis of chondrocytes in transgenic mice lacking collagen II.

H. Helminen, D. Prockop, S. W. Li, 1997, Experimental cell research.

Completion of the intron-exon structure of the gene for human type II procollagen (COL2A1): variations in the nucleotide sequences of the alleles from three chromosomes.

L. Ala‐Kokko, D. Prockop, L. Ala‐kokko, 1990, Genomics.

Efficient procedure for preparing cosmid libraries from microgram quantities of genomic DNA fragments size fractionated by gel electrophoresis.

L. Ala‐Kokko, D. Prockop, L. Ala‐kokko, 1990, Matrix.

Hydroxylation of prolyl residues in type II procollagen in vitro and in cellulo. Lack of preferential hydroxylation of specific regions of the protein.

D. Prockop, T. Kimura, 1982, Biochemistry.

Kinetics of the incorporation of tropoelastin into elastic fibers in embryonic chick aorta.

W. Kao, D. Prockop, G. Bressan, 1982, Connective tissue research.

Comparison of the NH2-Terminal sequences of chick Type I preprocollagen chains synthesized in an nRNA-dependent reticulocyte lysate.

B. Olsen, D. Prockop, P. Graves, 2005, European journal of biochemistry.

Synthesis of type I procollagen: formation of interchain disulfide bonds before complete hydroxylation of the protein.

J. Uitto, D. Prockop, V. Uitto, 1981, Archives of biochemistry and biophysics.

Proteolytic enzymes as probes for the triple-helical conformation of procollagen.

D. Prockop, P. Bruckner, 1981, Analytical biochemistry.

Addition of mannose to both the amino- and carboxy-terminal properties of type II procollagen occurs without formation of a triple helix.

D. Prockop, P. Graves, N. Guzman, 1978, Biochemical and biophysical research communications.

Synthesis of an elastin component of molecular weight about 70,000 by polysomes from chick embryo aortas.

D. Prockop, G. Bressan, P. Graves, 1978, Archives of biochemistry and biophysics.

Synthesis of elastin in aortas from chick embryos. Conversion of newly secreted elastin to cross-linked elastin without apparent proteolysis of the molecule.

D. Prockop, G. Bressan, 1977, Biochemistry.

Purification and partial characterization of the type II procollagen synthesized by embryonic cartilage cells.

J. Uitto, D. Prockop, H. Hoffmann, 1977, Archives of biochemistry and biophysics.

Is newly-secreted elastin cleaved to a smaller molecule before being incorporated into crosslinked elastin fibers?

D. Prockop, G. Bressan, 1977, Advances in experimental medicine and biology.

Interchain disulfide bonds at the COOH-terminal end of procollagen synthesized by matrix-free cells from chick embryonic tendon and cartilage.

B. Olsen, D. Prockop, H. Hoffmann, 1976, Archives of biochemistry and biophysics.

Affinity column purification of protocollagen proline hydroxylase from chick embryos and further characterization of the enzyme.

D. Prockop, R. Berg, 1973, The Journal of biological chemistry.

Comparison of the anti-inflammatory effects of induced pluripotent stem cell-derived and bone marrow-derived mesenchymal stromal cells in a murine model of corneal injury.

H. Lee, D. Prockop, R. Reger, 2017, Cytotherapy.

Mutations in Type 1 Procollagen That Cause Osteogenesis Imperfecta: Effects of the Mutations on the Assembly of Collagen into Fibrils, the Basis of Phenotypic Variations, and Potential Antisense Therapies

H. Helminen, D. Prockop, A. Colige, 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Cloning a cDNA for the pro-alpha 2 chain of human type I collagen.

S. Faro, D. Prockop, J. Myers, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Recombinant DNA and collagen research. Is amino acid sequencing obsolete? Can we study diseases involving collagen by analysis of the genes?

D. Prockop, 1980, Collagen and related research.

Multipotent Stromal Cells (hMSCs)

D. Prockop, R. Reger, M. Wolfe, 2009 .

Formation of the triple helix of type I procollagen in cellulo. A kinetic model based on cis-trans isomerization of peptide bonds.

E. Eikenberry, D. Prockop, P. Bruckner, 1981, European journal of biochemistry.

Iron-containing metallocenes as active site directed inhibitors of the proteinase that cleaves the NH2-terminal propeptides from type I procollagen.

D. Prockop, K. E. Dombrowski, J. Sheats, 1986, Biochemistry.

Mesenchymal stromal cells protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC1.

D. Prockop, M. Ebina, T. Nukiwa, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Heterozygous glycine substitution in the COL11A2 gene in the original patient with the Weissenbacher-Zweymüller syndrome demonstrates its identity with heterozygous OSMED (nonocular Stickler syndrome).

L. Ala‐Kokko, A. Winterpacht, D. Prockop, 1998, American journal of medical genetics.

cDNA clones coding for the pro-alpha1(IV) chain of human type IV procollagen reveal an unusual homology of amino acid sequences in two halves of the carboxyl-terminal domain.

T. Pihlajaniemi, D. Prockop, R. Lebo, 1985, The Journal of biological chemistry.

Structure of a full-length cDNA clone for the prepro alpha 2(I) chain of human type I procollagen. Comparison with the chicken gene confirms unusual patterns of gene conservation.

H. Kuivaniemi, G. Tromp, D. Prockop, 1988, Biochemical Journal.

The A and B fragments of normal type I procollagen have a similar thermal stability to proteinase digestion but are selectively destabilized by structural mutations.

D. Prockop, B. Vogel, J. Jeffrey, 1987, European journal of biochemistry.

TNFα-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury

A. Malik, D. Prockop, Saroj Nepal, 2016, Proceedings of the National Academy of Sciences.

Scalable Production of a Multifunctional Protein (TSG-6) That Aggregates with Itself and the CHO Cells That Synthesize It

D. Prockop, J. Oh, T. Bartosh, 2016, PloS one.

iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers

D. Prockop, R. Reger, J. Xu, 2017, Cell Death Discovery.

Lag between incorporation of proline into protocollagen and synthesis of hydroxyproline during collagen biosynthesis in vitro and in vivo.

J. Rosenbloom, D. Prockop, J. Lane, 1971, Nature: New biology.

Protocollagen proline hydroxylase from Ascaris lumbricoides.

D. Prockop, D. Fujimoto, 1969, The Journal of biological chemistry.

Hydroxylation of proline in synthetic polypeptides with purified protocollagen hydroxylase.

K. Kivirikko, D. Prockop, 1967, The Journal of biological chemistry.

Potential use of marrow stromal cells as therapeutic vectors for diseases of the central nervous system.

G. Kopen, D. Prockop, D. Phinney, 2000, Progress in brain research.

Enhanced In Situ Detection of β-Glucuronidase Activity in Murine Tissue

G. Kopen, D. Prockop, D. Phinney, 1999 .

Type II collagen and avascular necrosis of the femoral head.

D. Prockop, 2005, The New England journal of medicine.

Tissue-Specific Progenitor and Stem Cells Should Publications on Mesenchymal Stem / Progenitor Cells Include In-Process Data on the Preparation of the Cells ?

D. Prockop, R. Reger, Darwin J. Prockop, 2014 .

Assignment of the human collagen α1(XIII) chain gene (COL13A1) to the q22 region of chromosome 10

R. Eddy, T. Shows, D. Prockop, 1989 .

Antibodies to Chick‐Tendon Procollagen

B. Olsen, D. Prockop, P. Dehm, 1974 .

Synthesis and processing of a type I procollagen containing shortened pro-alpha 1(I) chains by fibroblasts from a patient with osteogenesis imperfecta.

D. Prockop, C. Williams, 1983, The Journal of biological chemistry.

Concanavalin A binds of purified prolyl hydroxylase and partially inhibits its enzymic activity.

D. Prockop, R. Berg, N. Guzman, 1976, Biochemical and biophysical research communications.

A to G polymorphism in ELN gene.

J. Rosenbloom, A. Christiano, H. Kuivaniemi, 1991, Nucleic acids research.

C to T polymorphism in exon 33 of the COL3A1 gene.

H. Kuivaniemi, G. Tromp, D. Prockop, 1991, Nucleic acids research.

Multipotent Stromal Cells Are Activated to Reduce Apoptosis in Part by Upregulation and Secretion of Stanniocalcin‐1

R. Pochampally, D. Prockop, C. Gregory, 2009, Stem cells.

A substitution of cysteine for glycine 748 of the alpha 1 chain produces a kink at this site in the procollagen I molecule and an altered N-proteinase cleavage site over 225 nm away.

J. Engel, K. Kadler, D. Prockop, 1988, The Journal of biological chemistry.

The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region.

D. Prockop, K. Tryggvason, R. Soininen, 1988, The Journal of biological chemistry.

Defining the probability that a cell therapy will produce a malignancy.

D. Prockop, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

A STUDY OF URINARY AND SERUM LYSOZYME IN PATIENTS WITH RENAL DISEASE.

D. Prockop, W. Davidson, 1964, The New England journal of medicine.

Studies on protocollagen lysine hydroxylase. Hydroxylation of synthetic peptides and the stoichiometric decarboxylation of -ketoglutarate.

K. Kivirikko, D. Prockop, S. Sakakibara, 1972, Biochemistry.

Expression of a partially deleted gene of human type II procollagen (COL2A1) in transgenic mice produces a chondrodysplasia.

L. Ala‐Kokko, H. Helminen, D. Prockop, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Detection of sequence variants in the gene for human type II procollagen (COL2A1) by direct sequencing of polymerase chain reaction‐amplified genomic DNA

L. Ala‐Kokko, C. Baldwin, I. Hopkinson, 1992, Human mutation.

Use of an antisense oligonucleotide to inhibit expression of a mutated human procollagen gene (COL1A1) in transfected mouse 3T3 cells.

B. Sokolov, D. Prockop, R. Baserga, 1993, Biochemistry.

Transcription of Human Type I Collagen Genes. Variation in the Relative Rates of Transcription of the Proα1 and Proα2 Genes

A. Olsen, D. Prockop, 1989 .

Use of conformation sensitive gel electrophoresis to detect single‐base changes in the gene for COL10A1

J. Milunsky, L. Ala‐Kokko, D. Prockop, 1998, Human mutation.

Titration and melting curves of the collagen-like triple helices formed from (Pro-Pro-Gly) in aqueous solution.

B. Olsen, D. Prockop, R. Berg, 1970, The Journal of biological chemistry.

INTRACELLULAR ACCUMULATION OF PROTOCOLLAGEN AND EXTRUSION OF COLLAGEN BY EMBRYONIC CARTILAGE CELLS

D. Prockop, G. Cooper, 1968, The Journal of cell biology.

Mutations in Collagen Genes as a Cause of Rare and Perhaps Common Diseases of Connective Tissue

D. Prockop, 1991, Acta paediatrica Scandinavica. Supplement.

Cadmium ions inhibit procollagen C-proteinase and cupric ions inhibit procollagen N-proteinase.

D. Prockop, Y. Hojima, A. M. Romanic, 1994, Matrix biology : journal of the International Society for Matrix Biology.

Propagation and senescence of human marrow stromal cells in culture: a simple colony‐forming assay identifies samples with the greatest potential to propagate and differentiate

R. Class, D. Prockop, D. Phinney, 1999, British journal of haematology.

Relearning the Lessons of Genomic Stability of Human Cells During Expansion in Culture: Implications for Clinical Research

D. Prockop, A. Keating, 2012, Stem cells.

Rapid detection of mutations by conformation-sensitive gel electrophoresis. Application to the identification of a fourth family with the Arg519→Cys substitution and three new mutations in the type II procollagen gene

D. Prockop, M. Rock, A. Ganguly, 1994 .

Stem cells and cell therapies in lung biology and lung diseases.

D. Warburton, B. Stripp, D. Prockop, 2011, Proceedings of the American Thoracic Society.

Mutations that substitute serine for glycine alpha 1-598 and glycine alpha 1-631 in type I procollagen. The effects on thermal unfolding of the triple helix are position-specific and demonstrate that the protein unfolds through a series of cooperative blocks.

D. Prockop, J. Kishi, A. Westerhausen, 1990, The Journal of biological chemistry.

Single base mutation in the type III procollagen gene that converts the codon for glycine 883 to aspartate in a mild variant of Ehlers-Danlos syndrome IV.

H. Kuivaniemi, G. Tromp, D. Prockop, 1989, The Journal of biological chemistry.

A single base mutation that converts glycine 907 of the alpha 2(I) chain of type I procollagen to aspartate in a lethal variant of osteogenesis imperfecta. The single amino acid substitution near the carboxyl terminus destabilizes the whole triple helix.

C. Baldwin, D. Prockop, K. Dumars, 1989, The Journal of biological chemistry.

Stop codon in the procollagen II gene (COL2A1) in a family with the Stickler syndrome (arthro-ophthalmopathy).

W. Tasman, S. Jimenez, L. Ala‐Kokko, 1991, Proceedings of the National Academy of Sciences of the United States of America.

A-2-->G transition at the 3' acceptor splice site of IVS17 characterizes the COL2A1 gene mutation in the original Stickler syndrome kindred.

D. Prockop, A. Ganguly, V. Michels, 1996, American journal of medical genetics.

A single base mutation in the type II procollagen gene (COL2A1) that converts glycine α1‐247 to serine in a family with late‐onset spondyloepiphyseal dysplasia

L. Ala‐Kokko, B. Sokolov, D. Prockop, 1994, Human mutation.

STUDIES WITH PROLINE-3,4,-H3 ON THE HYDROXYLATION OF PROLINE DURING COLLAGEN SYNTHESIS IN CHICK EMBRYOS.

D. Prockop, B. Shapiro, P. Ebert, 1964, Archives of biochemistry and biophysics.

Mesenchymal Stromal Cells Inhibit Inflammatory Lymphangiogenesis in the Cornea by Suppressing Macrophage in a TSG-6-Dependent Manner.

Dong Hyun Kim, Hyun Beom Song, D. Prockop, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

Structure of cDNA clones coding for the entire prepro alpha 1 (III) chain of human type III procollagen. Differences in protein structure from type I procollagen and conservation of codon preferences.

L. Ala‐Kokko, C. Baldwin, H. Kuivaniemi, 1989, The Biochemical journal.

Relative transcription rates and mRNA levels for the two chains of type I procollagen.

A. Olsen, D. Prockop, 1987, Methods in enzymology.

Human immunodeficiency virus type 1 Vpr alters bone marrow cell function.

D. Prockop, R. Pomerantz, A. Srinivasan, 1999, Blood.

Widely distributed mutations in the COL2A1 gene produce achondrogenesis type II/hypochondrogenesis.

L. Ala‐Kokko, D. Krakow, D. Prockop, 2000, American journal of medical genetics.

Intraperitoneally infused human mesenchymal stem cells form aggregates with mouse immune cells and attach to peritoneal organs

D. Prockop, Arezoo Mohammadipoor, T. Bartosh, 2016, Stem Cell Research & Therapy.

The biosynthesis of collagen and its disorders (first of two parts).

K. Kivirikko, D. Prockop, L. Tuderman, 1979, The New England journal of medicine.

Can mutated genes cause common osteoarthritis?

L. Ala‐Kokko, D. Prockop, D. Mclain, 1997, British journal of rheumatology.

Single base mutation in the type II procollagen gene (COL2A1) as a cause of primary osteoarthritis associated with a mild chondrodysplasia.

R. Moskowitz, L. Ala‐Kokko, C. Baldwin, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Refinement of the chromosome 5p locus for familial calcium pyrophosphate dihydrate deposition disease.

M. Devoto, M. Lathrop, S. Butcher, 1999, American journal of human genetics.

Nucleotide sequences of complementary deoxyribonucleic acids for the pro alpha 1 chain of human type I procollagen. Statistical evaluation of structures that are conserved during evolution.

M L Chu, D J Prockop, J C Myers, 1983, Biochemistry.

Copolymerization of pNcollagen III and collagen I. pNcollagen III decreases the rate of incorporation of collagen I into fibrils, the amount of collagen I incorporated, and the diameter of the fibrils formed.

K. Kadler, D. Prockop, E. Adachi, 1991, The Journal of biological chemistry.

Structure of a cDNA for the pro alpha 2 chain of human type I procollagen. Comparison with chick cDNA for pro alpha 2(I) identifies structurally conserved features of the protein and the gene.

M L Chu, D J Prockop, J C Myers, 1983, Biochemistry.

Variations in the glycosylation of the collagen synthesized by chick embryo cartilage. Effects of development and several hormones.

D. Prockop, N. Blumenkrantz, 1970, Biochimica et biophysica acta.

Collagens: molecular biology, diseases, and potentials for therapy.

D J Prockop, K. Kivirikko, D. Prockop, 1995, Annual review of biochemistry.

Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6.

P. Delafontaine, B. Larson, D. Prockop, 2009, Cell stem cell.

Mitochondrial transfer between cells can rescue aerobic respiration

Darwin J. Prockop, D. Prockop, Jeffrey L. Spees, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Aregenerative anemia associated with benign thymoma.

B. Clarkson, D. Prockop, 1958, The New England journal of medicine.

Intracellular Steps in the Biosynthesis of Collagen

J. Uitto, K. Kivirikko, D. Prockop, 1976 .

Does bound water contribute to the stability of collagen?

J. Engel, D. Prockop, 1998, Matrix biology : journal of the International Society for Matrix Biology.

Further evidence for a transport form of collagen. Its extrusion and extracellular conversion to tropocollagen in embryonic tendon.

S. Jimenez, D. Prockop, P. Dehm, 1971, FEBS letters.

Synthesis and extrusion of collagen by freshly isolated cells from chick embryo tendon

D. Prockop, P. Dehm, 1971 .

Hydroxylation of proline and lysine in protocollagen involves two separate enzymatic sites.

D. Prockop, N. Blumenkrantz, E. Weinstein, 1969, Biochimica et biophysica acta.

An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction.

D. Prockop, C. Gregory, A. Peister, 2004, Analytical biochemistry.

Human type I procollagen genes are located on different chromosomes.

M. Gross, C. Junien, A. de la Chapelle, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Conformation-sensitive gel electrophoresis for rapid detection of single-base differences in double-stranded PCR products and DNA fragments: evidence for solvent-induced bends in DNA heteroduplexes.

D J Prockop, D. Prockop, M. Rock, 1993, Proceedings of the National Academy of Sciences of the United States of America.

The complete cDNA coding sequence for the mouse proα1(I) chain of type I procollagen

D. Prockop, J. Khillan, Shi-Wu Li, 1995 .

Structure of a full-length cDNA clone for the prepro alpha 1(I) chain of human type I procollagen.

R. Jaenisch, C. Baldwin, H. Kuivaniemi, 1988, The Biochemical journal.

Heritable diseases of collagen.

K. Kivirikko, D. Prockop, 1984, The New England journal of medicine.

Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice.

D. Prockop, Jeffrey L. Spees, Jeffrey L Spees, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery

A. Manira, A. El Manira, L. Olson, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Regeneration after nerve transection: effect of inhibition of collagen synthesis.

D. Pleasure, D. Prockop, J. Lane, 1974, Experimental neurology.

Genetic diseases of connective tissues in animals.

D. Prockop, D. Patterson, R. Minor, 1987, Current problems in dermatology.

Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-α-induced protein 6

J. Lasky, D. Welsh, D. Prockop, 2011, Stem Cell Research & Therapy.

Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties

Nikolay Bazhanov, Hosoon Choi, D. Prockop, 2010, Proceedings of the National Academy of Sciences.

Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment.

Patrick Delafontaine, Burton E Sobel, B. Sobel, 2007, Biochemical and biophysical research communications.

Multipotential marrow stromal cells transduced to produce L-DOPA: engraftment in a rat model of Parkinson disease.

D. Prockop, G. Alexander, E. J. Schwarz, 1999, Human gene therapy.

Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice.

O. Bagasra, B. Sokolov, D. Prockop, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Incorporation of cis-hydroxyproline into collagen by tendon cells. Failure of the intracellular collagen to assume a triple-helical conformation.

J. Uitto, D. Prockop, P. Dehm, 1972, Biochimica et biophysica acta.

Inhibition of scar formation by the proline analog cis-hydroxyproline☆

D. Prockop, J. Black, J. Lane, 1972 .

Evidence for a structural mutation of procollagen type I in a patient with the Ehlers-Danlos syndrome type VII.

L. Peltonen, V. McKusick, D. Prockop, 1980, The Journal of biological chemistry.

Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy.

Shu-Ching Hsu, D. Prockop, Jeffrey L. Spees, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

Influence of Scurvy and Lathyrism (Odoratism) on Hydroxyproline Excretion

D. Prockop, G. Martin, S. Mergenhagen, 1961, Nature.

BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells.

I. Sekiya, D. Prockop, D. Colter, 2001, Biochemical and biophysical research communications.

Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta

Darwin J. Prockop, Malcolm K. Brenner, Reed E. Pyeritz, 1999, Nature Medicine.

Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation.

D. Prockop, Jeffrey L. Spees, C. Gregory, 2005, Experimental cell research.

Formation of enzyme-substrate complexes with protocollagen proline hydroxylase and large polypeptide substrates.

D. Prockop, K. Juva, 1969, The Journal of biological chemistry.

Effect of polymer size on the inhibition of protocollagen proline hydroxylase by polyproline II.

K. Kivirikko, D. Prockop, 1969, The Journal of biological chemistry.

Purification and partial characterization of the enzyme for the hydroxylation of proline in protocollagen

K. Kivirikko, D. Prockop, 1967 .

SYNTHESIS OF HYDROXYPROLINE IN VITRO BY THE HYDROXYLATION OF PROLINE IN A PRECURSOR OF COLLAGEN.

D. Prockop, K. Juva, 1965, Proceedings of the National Academy of Sciences of the United States of America.

Expansion of Human Adult Stem Cells from Bone Marrow Stroma: Conditions that Maximize the Yields of Early Progenitors and Evaluate Their Quality

I. Sekiya, R. Pochampally, B. Larson, 2002, Stem cells.

Precursors of the hydroxyproline and ketoproline in actinomycin.

E. Katz, D. Prockop, S. Undenfriend, 1962, The Journal of biological chemistry.

The intracellular biosynthesis of collagen. Some possible implications for diseases of bone and other connective tissues.

D. Prockop, 1969, Archives of internal medicine.

Inhibition of the Self-assembly of Collagen I into Fibrils with Synthetic Peptides

D. Prockop, A. Fertala, 1998, The Journal of Biological Chemistry.

Sarcoma Derived from Cultured Mesenchymal Stem Cells

M. Kay, J. Tolar, P. Hogendoorn, 2007, Stem cells.

Time lag in the secretion of collagen by matrix-free tendon cells and inhibition of the secretory process by colchicine and vinblastine.

D. Prockop, P. Dehm, 1972, Biochimica et biophysica acta.

Collagen degradation and the response to parathyroid extract in the intact rhesus monkey.

D. Prockop, L. Avioli, 1967, The Journal of clinical investigation.

Dissociation of the synthesis of sulphated mucopolysaccharides and the synthesis of collagen in embryonic cartilage.

D. Prockop, R. Bhatnagar, 1966, Biochimica et biophysica acta.

Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases.

A. Sieron, D. Prockop, J. Kramer, 2000, Development.

Studies on the intracellular localization of collagen synthesis in the intact chick embryo.

D. Prockop, B. Peterkofsky, Udenfriends, 1962, The Journal of biological chemistry.

An effect of puromycin on the synthesis of collagen by embryonic cartilage in vitro.

D. Prockop, K. Juva, 1966, The Journal of biological chemistry.

SOURCE OF THE ELEVATED SERUM ALKALINE PHOSPHATASE ACTIVITY IN BILIARY OBSTRUCTION: STUDIES UTILIZING ISOLATED LIVER PERFUSION.

D. Prockop, F. Bradshaw, D. Sebesta, 1964, Gastroenterology.

Synthesis of Collagen

D. Prockop, 1962, Nature.

Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: Variations in yield, growth, and differentiation

Gene Kopen, R. Isaacson, G. Kopen, 1999, Journal of cellular biochemistry.

Synthesis of (Pro-Hyp-Gly) n of defined molecular weights. Evidence for the stabilization of collagen triple helix by hydroxypyroline.

D. Prockop, K. Inouye, S. Sakakibara, 1973, Biochimica et biophysica acta.

Collagen diseases and the biosynthesis of collagen.

D. Prockop, N. Guzman, 1977, Hospital practice.

The synthetic polytripeptides (Pro-Pro-Gly)10 and (Pro-Pro-Gly)20 form micro-crystalline structures similar to segmental structures formed by collagen.

B. Olsen, D. Prockop, S. Sakakibara, 1971, Journal of molecular biology.

Further hydroxylation of lysyl residues in collagen by protocollagen lysyl hydroxylase in vitro.

P. Bornstein, K. Kivirikko, D. Prockop, 1973, Biochemistry.

Partial purification and characterization of protocollagen lysine hydroxylase from chick embryos.

K. Kivirikko, D. Prockop, 1972, Biochimica et biophysica acta.

Hydroxylation of lysine in a polypeptide precursor of collagen.

D. Prockop, E. Weinstein, T. Mulveny, 1966, Biochemical and biophysical research communications.

Inactivation of one allele of the type II collagen gene alters the collagen network in murine articular cartilage and makes cartilage softer

M. Hyttinen, H. Helminen, J. Jurvelin, 2001, Annals of the rheumatic diseases.

A method for the simultaneous measurement of the radioactivity of proline-C14 and hydroxyproline-C14 in biological materials.

D. Prockop, B. Peterkofsky, Darwin J. Prockop, 1962, Analytical biochemistry.

The biosynthesis of basement membrane collagen in embryonic chick lens. II. Synthesis of a precursor form by matrix-free cells and a time-dependent conversion to chains in intact lens.

D. Prockop, N. A. Kefalides, M. E. Grant, 1972, The Journal of biological chemistry.

Incorporation of cis-hydroxyproline into protocollagen and collagen. Collagen containing cis-hydroxyproline in place of proline and trans-hydroxyproline is not extruded at a normal rate.

J. Rosenbloom, D. Prockop, 1971, The Journal of biological chemistry.

Biosynthesis of cartilage procollagen.

D. Prockop, P. Dehm, Darwin J. Prockop, 1973, European journal of biochemistry.

Central-nervous-system effects of ingestin of L-tryptophan by normal subjects.

D. Prockop, B. Smith, B. Smith, 1962, The New England journal of medicine.

Steady-state levels of mRNAs coding for the type IV collagen and laminin polypeptide chains of basement membranes exhibit marked tissue-specific stoichiometric variations in the rat.

R. Boot-Handford, D. Prockop, M. Kurkinen, 1987, The Journal of biological chemistry.

Substitution of aspartic acid for glycine at position 310 in type II collagen produces achondrogenesis II, and substitution of serine at position 805 produces hypochondrogenesis: analysis of genotype-phenotype relationships.

L. Ala‐Kokko, J. Bonaventure, D. Prockop, 1995, The Biochemical journal.

Specific inhibition of expression of a human collagen gene (COL1A1) with modified antisense oligonucleotides. The most effective target sites are clustered in double-stranded regions of the predicted secondary structure for the mRNA.

D. Prockop, A. Colige, Z. Lu, 1994, Biochemistry.

Mutations in COL11A2 cause non-syndromic hearing loss (DFNA13)

M. King, C. Cremers, H. Brunner, 1999, Nature Genetics.

Collagen II containing a Cys substitution for arg-alpha1-519. Homotrimeric monomers containing the mutation do not assemble into fibrils but alter the self-assembly of the normal protein.

L. Ala‐Kokko, D. Prockop, A. Fertala, 1997, The Journal of biological chemistry.

ABCA12 Is a Major Causative Gene for Non-Bullous Congenital Ichthyosiform Erythroderma

H. Kuivaniemi, G. Tromp, D. Prockop, 2009 .

Hydroxylation of proline after the release of proline-rich polypeptides from ribosomal complexes during uninhibited collagen biosynthesis.

J. Rosenbloom, D. Prockop, R. Bhatnagar, 1967, Biochimica et biophysica acta.

Quantitative assay for hydroxylysine in protein hydrolyzates.

D. Prockop, N. Blumenkrantz, 1971, Analytical biochemistry.

Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms.

D. Prockop, 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

Deletion of 19 base pairs in intron 13 of the gene for the proα2(I) chain of type-I procollagen (COL1A2) causes exon skipping in a proband with type-I osteogenesis imperfecta

H. Kuivaniemi, G. Tromp, D. Prockop, 1993, Human Genetics.

Exclusion of COL1A1, COL1A2, and COL3A1 genes as candidate genes for Ehlers-Danlos syndrome type I in one large family

G. Tromp, B. Sokolov, D. Prockop, 1991, Human Genetics.

Synthesis and conformational properties of a recombinant C-propeptide of human type III procollagen.

H. Kuivaniemi, G. Tromp, A. Sieron, 1997, Matrix biology : journal of the International Society for Matrix Biology.

Transgenic mice expressing a partially deleted gene for type I procollagen (COL1A1). A breeding line with a phenotype of spontaneous fractures and decreased bone collagen and mineral.

H. Helminen, D. Prockop, E. Hume, 1993, The Journal of clinical investigation.

Temperature sensitivity of aberrant RNA splicing with a mutation in theG+5 position of intron 37 of the gene for type III procollagen from a patient with Ehlers–Danlos syndrome type IV

H. Kuivaniemi, G. Tromp, D. Prockop, 1993, Human mutation.

A 15 base-pair AT-rich variable number tandem repeat in the type III procollagen gene (COL3A1) as an informative marker for 2q31-2q32.3.

H. Kuivaniemi, G. Tromp, D. Prockop, 1992, Matrix.

Completion of the last half of the structure of the human gene for the Pro alpha 1 (I) chain of type I procollagen (COL1A1).

A. Olsen, D. Prockop, C. Constantinou, 1991, Matrix.

Osteopenia in 37 Members of Seven Families: Analysis Based on a Model of Dominant Inheritance

J. Ott, M. Devoto, D. Prockop, 1996, Molecular medicine.

Robotic automation of dideoxyribonucleotide sequencing reactions.

J J Earley, H Kuivaniemi, D J Prockop, 1994, BioTechniques.

Sequence and genomic organization of the human G-protein Golfα gene (GNAL) on chromosome 18p11, a susceptibility region for bipolar disorder and schizophrenia

J. Vuoristo, L. Ala‐Kokko, D. Prockop, 2000, Molecular Psychiatry.

Mutations in Osteogenesis Imperfecta Leading to the Synthesis of Abnormal Type I Procollagens

T. Pihlajaniemi, D. Prockop, J. Myers, 1985, Annals of the New York Academy of Sciences.

Mutations in collagen genes. Consequences for rare and common diseases.

D. Prockop, 1985, The Journal of clinical investigation.

Complete Structure of the Human COL11A2 Gene: The Exon Sizes and other Features Indicate the Gene Has Not Evolved with Genes for Other Fibriller Collagens

L. Ala‐Kokko, D. Prockop, T. Pihlajamaa, 1996, Annals of the New York Academy of Sciences.

Human Mesenchymal Stem/Stromal Cells Cultured as Spheroids are Self‐activated to Produce Prostaglandin E2 that Directs Stimulated Macrophages into an Anti‐inflammatory Phenotype

D. Prockop, T. Bartosh, Darwin J Prockop, 2012, Stem cells.

Rat Marrow Stromal Cells are More Sensitive to Plating Density and Expand More Rapidly from Single‐Cell‐Derived Colonies than Human Marrow Stromal Cells

D. Prockop, E. J. Schwarz, D. Colter, 2001, Stem cells.

The hydroxylation of proline to hydroxyproline during the synthesis of collagen in chick embryos.

D. Prockop, P. Ebert, 1962, Biochemical and biophysical research communications.

A review and rationale for the use of cellular transplantation as a therapeutic strategy for traumatic brain injury.

J. Trojanowski, E. Snyder, A. Maas, 2004, Journal of neurotrauma.

One strategy for cell and gene therapy: Harnessing the power of adult stem cells to repair tissues

D. Prockop, C. Gregory, Jeffery L. Spees, 2003, Proceedings of the National Academy of Sciences of the United States of America.

ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride–induced hepatic fibrosis in mice

I. Leclercq, M. Thiry, J. Arrese, 2007, Hepatology.

Cloning and Characterization of ADAMTS-14, a Novel ADAMTS Displaying High Homology with ADAMTS-2 and ADAMTS-3*

J. V. Van Beeumen, M. Thiry, D. Prockop, 2002, The Journal of Biological Chemistry.

The exciting prospects of new therapies with mesenchymal stromal cells.

D. Prockop, Darwin J Prockop, 2017, Cytotherapy.

Medical therapies with adult stem/progenitor cells (MSCs): A backward journey from dramatic results in vivo to the cellular and molecular explanations

D. Prockop, J. Oh, Darwin J. Prockop, 2012, Journal of cellular biochemistry.

Radial packing, order, and disorder in collagen fibrils.

D J Prockop, P. Fratzl, D. Prockop, 1995, Biophysical journal.

Genetic linkage of a polymorphism in the type II procollagen gene (COL2A1) to primary osteoarthritis associated with mild chondrodysplasia.

R. Moskowitz, S. Jimenez, D. Prockop, 1990, The New England journal of medicine.

Genetic linkage analysis of hereditary arthro-ophthalmopathy (Stickler syndrome) and the type II procollagen gene.

S. Jimenez, J. Uitto, D. Prockop, 1989, American journal of human genetics.

Identification and cloning of integration site of DNA by PCR.

D. Prockop, S. W. Li, J. Khillan, 1996, BioTechniques.

Stem cells and cell therapies in lung biology and lung diseases.

L. Ortiz, D. Prockop, J. Kolls, 2008, Proceedings of the American Thoracic Society.

Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI

D. Prockop, A. Shetty, T. Bartosh, 2015, Proceedings of the National Academy of Sciences.

Short-Term Exposure of Multipotent Stromal Cells to Low Oxygen Increases Their Expression of CX3CR1 and CXCR4 and Their Engraftment In Vivo

Darwin J. Prockop, Shu-Ching Hsu, R. Pochampally, 2007, PloS one.

The triple helix ⇌ coil conversion of collagen‐like polytripeptides in aqueous and nonaqueous solvents. Comparison of the thermodynamic parameters and the binding of water to (L‐Pro‐L‐Pro‐Gly)n and (L‐Pro‐L‐Hyp‐Gly)n

J. Engel, H. Klump, D. Prockop, 1977 .

A 19-base pair deletion in the pro-alpha 2(I) gene of type I procollagen that causes in-frame RNA splicing from exon 10 to exon 12 in a proband with atypical osteogenesis imperfecta and in his asymptomatic mother.

H. Kuivaniemi, G. Tromp, D. Prockop, 1988, The Journal of biological chemistry.

Single base mutation in the pro alpha 2(I) collagen gene that causes efficient splicing of RNA from exon 27 to exon 29 and synthesis of a shortened but in-frame pro alpha 2(I) chain.

G. Tromp, D. Prockop, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Restriction fragment length polymorphism associated with the pro alpha 2(I) gene of human type I procollagen. Application to a family with an autosomal dominant form of osteogenesis imperfecta.

D. Prockop, J. Myers, P. Tsipouras, 1983, The Journal of clinical investigation.

Drosha regulates hMSCs cell cycle progression through a miRNA independent mechanism.

R. Pochampally, D. Prockop, P. Penfornis, 2011, The international journal of biochemistry & cell biology.

A single base mutation that substitutes serine for glycine 790 of the alpha 1 (III) chain of type III procollagen exposes an arginine and causes Ehlers-Danlos syndrome IV.

H. Kuivaniemi, G. Tromp, D. Prockop, 1989, The Journal of biological chemistry.

Recombinant C-proteinase and processes, methods and uses thereof

A. Sieron, D. Prockop, Y. Hojima, 1997 .

G to A polymorphism in exon 31 of the COL3A1 gene.

H. Kuivaniemi, G. Tromp, D. Prockop, 1990, Nucleic acids research.

Intranasally Administered Human MSC-Derived Extracellular Vesicles Pervasively Incorporate into Neurons and Microglia in both Intact and Status Epilepticus Injured Forebrain

D. Prockop, D. Gitaí, Sahithi Attaluri, 2019, International journal of molecular sciences.

Intracellular Hydroxylation of Non-Helical Protocollagen to Form Triple-Helical and Subsequent Secretion of the Molecule Procollagen

J. Uitto, D. Prockop, 1974 .

PUROMYCIN INHIBITION OF COLLAGEN SYNTHESIS AS EVIDENCE FOR A RIBOSOMAT OR POST-RIBOSOMAL SITE FOR THE HYDROXYLATION OF PROLINE.

D. Prockop, K. Juva, 1964, Biochimica et biophysica acta.

Isotopic studies on urinary hydroxyproline as evidence for rapidly catabolized forms of collagen in the young rat.

D. Prockop, S. Lindstedt, 1961, The Journal of biological chemistry.

Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1).

L. Peltonen, R. Winqvist, K. Kadler, 1996, Gene.

Detection of single-base mutations by reaction of DNA heteroduplexes with a water-soluble carbodiimide followed by primer extension: application to products from the polymerase chain reaction

A. Ganguly, D. J. Prockop, D. Prockop, 1990, Nucleic Acids Res..

Procollagen N-proteinase and procollagen C-proteinase. Two unusual metalloproteinases that are essential for procollagen processing probably have important roles in development and cell signaling.

A. Sieron, D. Prockop, S. W. Li, 1998, Matrix biology : journal of the International Society for Matrix Biology.

Sequential cleavage of type I procollagen by procollagen N-proteinase. An intermediate containing an uncleaved pro alpha 1(I) chain.

D. Prockop, K. Tanzawa, J. Berger, 1985, Biochemistry.

Synthesis of recombinant human procollagen II in a stably transfected tumour cell line (HT1080).

L. Ala‐Kokko, A. Sieron, D. Prockop, 1994, The Biochemical journal.

Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats--similarities to astrocyte grafts.

D. Prockop, S. A. Azizi, C. DiGirolamo, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Preactivation of human MSCs with TNF-α enhances tumor-suppressive activity.

D. Prockop, N. Yoon, J. Reneau, 2012, Cell stem cell.

Defining the risks of mesenchymal stromal cell therapy.

Donald G Phinney, Armand Keating, Luc Sensebe, 2010, Cytotherapy.

Donor variation in the growth properties and osteogenic potential of human marrow stromal cells

D J Prockop, G. Kopen, D. Prockop, 1999, Journal of cellular biochemistry.

Engraftment of bone marrow progenitor cells in a rat model of asbestos-induced pulmonary fibrosis.

J. Lasky, A. Brody, D. Prockop, 2007, American journal of respiratory and critical care medicine.

Adult Stem Cells, Lung Biology, and Lung Disease

M. A. Berberich, D. Gail, C. Penland, 2006 .

Soliciting Strategies for Developing Cell-Based Reference Materials to Advance Mesenchymal Stromal Cell Research and Clinical Translation

Glyn Stacey, Peiman Hematti, Sowmya Viswanathan, 2014 .

Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential.

B. Larson, D. Prockop, L. Gibson, 2004, Blood.

Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells

D J Prockop, D. Prockop, D C Colter, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs)

Nikolay Bazhanov, D. Prockop, R. Reger, 2010, Journal of cellular and molecular medicine.

The CD34-like protein PODXL and alpha6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice.

D. Prockop, Min-Jeong Seo, A. Pulin, 2009, Blood.

TSG-6 as a biomarker to predict efficacy of human mesenchymal stem/progenitor cells (hMSCs) in modulating sterile inflammation in vivo

D. Prockop, J. Oh, J. Reneau, 2014, Proceedings of the National Academy of Sciences.

Human Multipotent Stromal Cells (MSCs) Increase Neurogenesis and Decrease Atrophy of the Striatum in a Transgenic Mouse Model for Huntington's Disease

D. Prockop, Brooke R. Snyder, A. Chan, 2010, PloS one.

Utilization of Marrow Stromal Cells for Gene Transfer into the CNS

D. Prockop, G. Alexander, K. Mortati, 2003 .

INCORPORATION OF SULFATE AND THE SYNTHESIS OF COLLAGEN BY CULTURES OF EMBRYONIC CHONDROCYTES.

D. Prockop, H. Holtzer, O. Pettengill, 1964, Biochimica et biophysica acta.

Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells.

B. Larson, D. Prockop, C. Gregory, 2010, Tissue engineering. Part A.

Effect of cycloheximide on collagen biosynthesis as evidence for a post-ribosomal site for the hydroxylation of proline.

J. Rosenbloom, K. Kivirikko, D. Prockop, 1967, Biochimica et biophysica acta.

Intracellular Pool of Unhydroxylated Polypeptide Precursors of Collagen

J. Rosenbloom, D. Prockop, R. Bhatnagar, 1967, Science.

HYDROXYLATION OF PROLINE IN PARTICULATE FRACTIONS FROM CARTILAGE.

D. Prockop, K. Juva, 1965, Biochemical and Biophysical Research Communications - BBRC.

The collagen fibril: the almost crystalline structure.

D. Prockop, A. Fertala, Darwin J. Prockop, 1998, Journal of structural biology.

Assembly in vitro of thin and thick fibrils of collagen II from recombinant procollagen II. The monomers in the tips of thick fibrils have the opposite orientation from monomers in the growing tips of collagen I fibrils.

K. Kadler, A. Sieron, D. Prockop, 1996, The Journal of biological chemistry.

Sequential hydroxylation of lysine and glycosylation of hydroxylysine during the biosynthesis of collagen in isolated cartilage.

J. Rosenbloom, D. Prockop, N. Blumenkrantz, 1968, Biochemical and biophysical research communications.

Studies on the synthesis and intracellular accumulation of protocollagen in organ culture of embryonic cartilage.

K. Kivirikko, D. Prockop, R. Bhatnagar, 1968, Biochimica et biophysica acta.

Partial characterization of protocollagen from embryonic cartilage.

K. Kivirikko, D. Prockop, 1967, The Biochemical journal.

Transfer of puromycin-containing polypeptides through the plasma membrane of cartilage cells synthesizing collagen.

J. Rosenbloom, K. Kivirikko, D. Prockop, 1967, Proceedings of the National Academy of Sciences of the United States of America.

Sequential steps in the synthesis of hydroxylysine and the glycosylation of hydroxylysine during the biosynthesis of collagen.

J. Rosenbloom, D. Prockop, N. Blumenkrantz, 1969, Biochimica et biophysica acta.

A simple technique for measuring the specific activity of labeled hydroxyproline in biological materials.

S. Udenfriend, D. Prockop, S. Lindstedt, 1961, The Journal of biological chemistry.

How Wnt Signaling Affects Bone Repair by Mesenchymal Stem Cells from the Bone Marrow

D. Prockop, Jeffrey L. Spees, C. Gregory, 2005, Annals of the New York Academy of Sciences.

Denatured collagen from the cuticle of Ascaris lumbricoides as a substrate for protocollagen proline hydroxylase.

D. Prockop, D. Fujimoto, 1968, The Journal of biological chemistry.

In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis

Darwin J. Prockop, I. Sekiya, J. Vuoristo, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Adult Bone Marrow Stem/Progenitor Cells (MSCs) Are Preconditioned by Microenvironmental "Niches" in Culture: A Two-Stage Hypothesis for Regulation of MSC Fate

D. Prockop, C. Gregory, J. Ylostalo, 2005, Science's STKE.

Hydroxyprolinemia as an illustration of nonessential enzymes in man.

D. Prockop, 1970, The New England journal of medicine.

Implantation of allogenic synovial stem cells promotes meniscal regeneration in a rabbit meniscal defect model.

I. Sekiya, D. Prockop, M. Driscoll, 2012, The Journal of bone and joint surgery. American volume.

Conformation sensitive gel electrophoresis for simple and accurate detection of mutations: comparison with denaturing gradient gel electrophoresis and nucleotide sequencing.

L. Ala‐Kokko, D. Prockop, T. Pihlajamaa, 1998, Proceedings of the National Academy of Sciences of the United States of America.

The Wnt Signaling Inhibitor Dickkopf-1 Is Required for Reentry into the Cell Cycle of Human Adult Stem Cells from Bone Marrow*

D. Prockop, C. Gregory, Anthony S. Perry, 2003, Journal of Biological Chemistry.

Synthesis of a shortened pro-alpha 2(I) chain and decreased synthesis of pro-alpha 2(I) chains in a proband with osteogenesis imperfecta.

T. Pihlajaniemi, D. Prockop, J. Myers, 1983, The Journal of biological chemistry.

A heterozygous defect for structurally altered pro-alpha 2 chain of type I procollagen in a mild variant of osteogenesis imperfecta. The altered structure decreases the thermal stability of procollagen and makes it resistant to procollagen N-proteinase.

D. Prockop, S. Kaffe, M. Sippola, 1984, The Journal of biological chemistry.

Inhibitors of procollagen N-protease. Synthetic peptides with sequences similar to the cleavage site in the pro alpha 1(I) chain.

D. Prockop, T. Morikawa, L. Tuderman, 1980, Biochemistry.

Thermal stability of type I and type III procollagens from normal human fibroblasts and from a patient with osteogenesis imperfecta.

L. Peltonen, A. Palotie, D. Prockop, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Segment-long-spacing aggregates and isolation of COOH-terminal peptides from type I procollagen.

B. Olsen, D. Prockop, H. Hoffmann, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Procollagen-a precursor form of collagen.

D. Prockop, J. Schofield, 1973, Clinical orthopaedics and related research.

The molecular defect in a nonlethal variant of osteogenesis imperfecta. Synthesis of pro-alpha 2(I) chains which are not incorporated into trimers of type I procollagen.

D. Prockop, F. Pope, A. Nicholls, 1983, The Journal of biological chemistry.

The biosynthesis of collagen and its disorders (second of two parts).

K. Kivirikko, D. Prockop, L. Tuderman, 1979, The New England journal of medicine.

Small-molecule antagonist of macrophage migration inhibitory factor enhances migratory response of mesenchymal stem cells to bronchial epithelial cells.

Katie C. Russell, D. Prockop, D. Phinney, 2009, Tissue engineering. Part A.

Isolation and partial characterization of the amino-terminal propeptide of type II procollagen from chick embryos.

D. Prockop, S. Curran, 1982, Biochemistry.

Expression of type I procollagen genes.

H. Kuivaniemi, G. Tromp, K. Kadler, 1988, Ciba Foundation symposium.

Characterization of the precursor forms of the 1 and 2 chains of collagen from matrix-free tendon cells.

S. Jimenez, J. Uitto, D. Prockop, 1972, Biochimica et biophysica acta.

How does a skin fibroblast make type I collagen fibers?

D. Prockop, 1982, The Journal of investigative dermatology.

Posttranslational enzymes in the biosynthesis of collagen: extracellular enzymes.

D. Prockop, L. Tuderman, 1982, Methods in enzymology.

Mutations in Human Procollagen Genes

R. Brent, L. Ala‐Kokko, D. Prockop, 1990, Annals of the New York Academy of Sciences.

Mutations in type I procollagen genes that cause osteogenesis imperfecta.

C. Baldwin, D. Prockop, C. Constantinou, 1990, Advances in human genetics.

Electronmicroscopic Localization of Deletions in the Human Pro‐α2(I) Collagen Gene a

D. Prockop, M. Bernard, M. Chu, 1985 .

Biosynthesis of cartilage procollagen. Influence of chain association and hydroxylation of prolyl residues on the folding of the polypeptides into the triple-helical conformation.

J. Uitto, D. Prockop, 1974, Biochemistry.

Ferritin-conjugated antibodies used for labeling of organelles involved in the cellular synthesis and transport of procollagen.

B. Olsen, D. Prockop, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Transcription of human type I collagen genes. Variation in the relative rates of transcription of the pro alpha 1 and pro alpha 2 genes.

A. Olsen, D. Prockop, 1989, Matrix.

Multipotent Stromal Cells Are Activated to Reduce Apoptosis in Part by Upregulation and Secretion of Stanniocalcin‐1

R. Pochampally, D. Prockop, C. Gregory, 2009 .

Splicing mutations of 54-bp exons in the COL11A1 gene cause Marshall syndrome, but other mutations cause overlapping Marshall/Stickler phenotypes.

D J Prockop, I. Kaitila, A. Latos-Bieleńska, 1999, American journal of human genetics.

A 1,064 bp fragment from the promoter region of the Col11a2 gene drives lacZ expression not only in cartilage but also in osteoblasts adjacent to regions undergoing both endochondral and intramembranous ossification in mouse embryos.

G. Kopen, D. Prockop, S. W. Li, 1998, Matrix biology : journal of the International Society for Matrix Biology.

The mouse col11a2 gene. Some transcripts from the adjacent rxr-beta gene extend into the col11a2 gene.

L. Ala‐Kokko, D. Prockop, P. Vandenberg, 1996, Matrix biology : journal of the International Society for Matrix Biology.

Bone turnover and type I collagen C-telopeptide isomerization in adult osteogenesis imperfecta: associations with collagen gene mutations.

D. Prockop, A. Schott, P. Garnero, 2009, Bone.

Osteogenesis imperfecta. A model for genetic causes of osteoporosis and perhaps several other common diseases of connective tissue.

D. Prockop, 1988, Arthritis and rheumatism.

Serum deprivation of human marrow stromal cells (hMSCs) selects for a subpopulation of early progenitor cells with enhanced expression of OCT-4 and other embryonic genes.

R. Pochampally, D. Prockop, J. Ylostalo, 2004, Blood.

Why should mesenchymal stem cells (MSCs) cure autoimmune diseases?

Antonio Uccelli, D. Prockop, A. Uccelli, 2010, Current opinion in immunology.

In Vitro Macrophage Assay Predicts the In Vivo Anti-inflammatory Potential of Exosomes from Human Mesenchymal Stromal Cells

Darwin J. Prockop, D. Prockop, G. Yannarelli, 2018, Molecular therapy. Methods & clinical development.

Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus

D. Prockop, D. Upadhya, A. Shetty, 2017, Proceedings of the National Academy of Sciences.

A defect in the structure of type I procollagen in a patient who had osteogenesis imperfecta: excess mannose in the COOH-terminal propeptide.

L. Peltonen, A. Palotie, D. Prockop, 1980, Proceedings of the National Academy of Sciences of the United States of America.

The clinical features of homozygous alpha 2(I) collagen deficient osteogenesis imperfecta.

D. Prockop, J. Myers, F. Pope, 1984, Journal of medical genetics.

Osteogenesis imperfecta: cloning of a pro-alpha 2(I) collagen gene with a frameshift mutation.

T. Pihlajaniemi, D. Prockop, J. Myers, 1984, The Journal of biological chemistry.

Altered helical structure of a homotrimer of alpha 1(I)chains synthesized by fibroblasts from a variant of osteogenesis imperfecta.

D. Prockop, M. E. van der Rest, S. Deak, 1985, Collagen and related research.

Rat adult stem cells (marrow stromal cells) engraft and differentiate in chick embryos without evidence of cell fusion.

R. Pochampally, D. Prockop, E. J. Schwarz, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Copolymerization of normal type I collagen with three mutated type I collagens containing substitutions of cysteine at different glycine positions in the alpha 1 (I) chain.

D. Prockop, E. Adachi, A. M. Romanic, 1992, The Journal of biological chemistry.

DNA polymorphisms in collagen genes: potential use in the study of disease.

A. Børresen, D. Prockop, K. Berg, 1985, Progress in clinical and biological research.

Substitution of cysteine for glycine-alpha 1-691 in the pro alpha 1(I) chain of type I procollagen in a proband with lethal osteogenesis imperfecta destabilizes the triple helix at a site C-terminal to the substitution.

D. Prockop, A. Superti-Furga, B. Steinmann, 1991, The Biochemical journal.

Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration

D. Prockop, D. Upadhya, Sahithi Attaluri, 2018, Proceedings of the National Academy of Sciences.

Dynamic compaction of human mesenchymal stem/precursor cells into spheres self‐activates caspase‐dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6, and STC1)

D. Prockop, T. Bartosh, N. Bazhanov, 2013, Stem cells.

Human mesenchymal stromal cells (MSCs) reduce neointimal hyperplasia in a mouse model of flow-restriction by transient suppression of anti-inflammatory cytokines.

R. Pochampally, D. Prockop, C. Malone, 2011, Journal of atherosclerosis and thrombosis.

Multipotent mesenchymal stromal cells attenuate chronic inflammation and injury-induced sensitivity to mechanical stimuli in experimental spinal cord injury.

L. Olson, D. Prockop, Z. Wiesenfeld‐Hallin, 2009, Restorative neurology and neuroscience.

Hydroxyprolinemia and increased excretion of free hydroxyproline in early infancy.

D. Prockop, G. Morrow, K. I. Kivitikko, 1966, The Journal of clinical endocrinology and metabolism.

Targeting gene therapy for osteogenesis imperfecta.

D. Prockop, 2004, The New England journal of medicine.

A Crosstalk Between Myeloma Cells and Marrow Stromal Cells Stimulates Production of DKK1 and Interleukin‐6: A Potential Role in the Development of Lytic Bone Disease and Tumor Progression in Multiple Myeloma

D. Prockop, S. Olson, C. Gregory, 2006, Stem cells.

Isolation and characterization of rapidly self-renewing stem cells from cultures of human marrow stromal cells.

I. Sekiya, D. Prockop, D. Colter, 2001, Cytotherapy.

An interpretation of the action of psychotropic drugs.

B. Brodie, D. Prockop, P. A. Shore, 1958, Postgraduate medicine.

Labeled antibodies to protocollagen proline hydroxylase from chick embryos for intracellular localization of the enzyme.

B. Olsen, D. Prockop, R. Berg, 1972, Biochimica et biophysica acta.

The biosynthesis of basement membrane collagen in embryonic chick lens. 3. Intracellular formation of the triple helix and the formation of aggregates through disulfide bonds.

D. Prockop, N. A. Kefalides, M. E. Grant, 1973, The Journal of biological chemistry.

Univariate and bivariate variance component linkage analysis of a whole-genome scan for loci contributing to bone mineral density

M. Devoto, H. Rydbeck, D. Prockop, 2005, European Journal of Human Genetics.

Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions.

D. Prockop, S. Olson, 2007, Blood.

A subset of human rapidly self-renewing marrow stromal cells preferentially engraft in mice.

R. Pochampally, D. Prockop, J. Jung, 2006, Blood.

MYELIN SYNTHESIS IN PERIPHERAL NERVE IN VITRO: SULPHATIDE INCORPORATION REQUIRES A TRANSPORT LIPOPROTEIN 1, 2, 3

D. Prockop, D. Pleasure, D. J. Prockop, 1972, Journal of neurochemistry.

Dkk-1-derived Synthetic Peptides and Lithium Chloride for the Control and Recovery of Adult Stem Cells from Bone Marrow*

D. Prockop, C. Gregory, Anthony S. Perry, 2005, Journal of Biological Chemistry.

A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies

R. Kutner, D. Prockop, O. David, 2007, British Journal of Cancer.

Mass spectrometric gene diagnosis of one-base substitution from polymerase chain reaction amplified human DNA.

D. Prockop, R. Arakawa, K. Ishikawa, 1997, Rapid communications in mass spectrometry : RCM.

Inhibition of collagen synthesis by the proline analogue cis-4-hydroxyproline.

D. Prockop, E. Steiger, J. Daly, 1973, The Journal of surgical research.

Marrow stromal cells as stem cells for continual renewal of nonhematopoietic tissues and as potential vectors for gene therapy

D. Prockop, 1998, Journal of cellular biochemistry.

A rapid assay for 14C-labeled hydroxylysine in collagen and related materials.

D. Prockop, N. Blumenkrantz, 1969, Analytical biochemistry.

A Single Base Mutation in Type III Procollagen That Converts the Codon for Glycine 619 to Arginine in a Family with Familial Aneurysms and Mild Bleeding Tendencies a

H. Kuivaniemi, G. Tromp, D. Prockop, 1990 .

The gene for the alpha 1(IV) chain of human type IV procollagen: the exon structures do not coincide with the two structural subdomains in the globular carboxy‐terminus of the protein.

L. Chow, D. Prockop, K. Tryggvason, 1986, The EMBO journal.

Large introns in the 3' end of the gene for the pro alpha 1 (IV) chain of human basement membrane collagen.

L. Chow, T. Pihlajaniemi, D. Prockop, 1986, Proceedings of the National Academy of Sciences of the United States of America.

The triple helix in equilibrium with coil conversion of collagen-like polytripeptides in aqueous and nonaqueous solvents. Comparison of the thermodynamic parameters and the binding of water to (L-Pro-L-Pro-Gly)n and (L-Pro-L-Hyp-Gly)n.

J. Engel, H. Klump, D. Prockop, 1977, Biopolymers.

Purification of (14C) protocollagen and its hydroxylation by prolyl-hydroxylase.

D. Prockop, R. Berg, 1973, Biochemistry.

Synthesis and physical properties of (hydroxyproline-proline-glycine)10: hydroxyproline in the X-position decreases the melting temperature of the collagen triple helix.

D J Prockop, Y. Kyōgoku, D. Prockop, 1982, Archives of biochemistry and biophysics.

Catabolism and excretion of free hydroxyproline in infancy.

K. Kivirikko, D. Prockop, G. Morrow, 1967, The Journal of clinical endocrinology and metabolism.

Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma

I. Sekiya, J. Vuoristo, B. Larson, 2005, Cell and Tissue Research.

Detection of mismatched bases in double stranded DNA by gel electrophoresis

D. Prockop, A. Ganguly, 1995, Electrophoresis.

Concise Review: Two negative feedback loops place mesenchymal stem/stromal cells at the center of early regulators of inflammation

D. Prockop, Darwin J Prockop, 2013, Stem cells.

Human multipotent stromal cells from bone marrow and microRNA: Regulation of differentiation and leukemia inhibitory factor expression

R. Pochampally, D. Prockop, E. Flemington, 2008, Proceedings of the National Academy of Sciences.

Antibodies to chick-tendon procollagen. Affinity purification with the isolated disulfide-linded NH2-terminal extensions and reactivity with a component in embryonic serum.

B. Olsen, D. Prockop, P. Dehm, 1974, European journal of biochemistry.

Are Clinical Trials With Mesenchymal Stem/Progenitor Cells too Far Ahead of the Science? Lessons From Experimental Hematology

D. Prockop, S. Prockop, I. Bertoncello, 2014, Stem cells.

A new epidermal growth factor-like domain in the human core protein for the large cartilage-specific proteoglycan. Evidence for alternative splicing of the domain.

D J Prockop, C. Baldwin, D. Prockop, 1989, The Journal of biological chemistry.

Stem cells and cell therapies in lung biology and diseases: conference report.

J. Bates, W. Liles, D. Prockop, 2013, Annals of the American Thoracic Society.

Deletion of a large domain in recombinant human procollagen II does not alter the thermal stability of the triple helix.

L. Ala‐Kokko, A. Sieron, D. Prockop, 1993, The Journal of biological chemistry.

Genetic Trail of Osteoporosis: Candidate Genes Versus Genome Screens? Small Families Versus Large Families?

D. Prockop, 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

EFFECTS OF HYDROCORTISONE ON THE SYNTHESIS OF SULPHATED MUCOPOLYSACCHARIDES AND COLLAGEN IN CHICK EMBRYOS.

D. Prockop, P. Ebert, 1963, Biochimica et Biophysica Acta.

Novel object recognition in Apoe −/− mice improved by neonatal implantation of wild-type multipotential stromal cells

J. Raber, D. Prockop, R. Reger, 2006, Experimental Neurology.

MSCs: Changing Hypotheses, Paradigms, and Controversies on Mechanisms of Action in Repairing Tissues

D. Prockop, R. Reger, 2013 .

Fundamentals of Culture and Characterization of Mesenchymal Stem/Progenitor Cells (MSCs) from Bone Marrow Stroma

Darwin J. Prockop, Carl A. Gregory, D. Prockop, 2007 .

Expression of human COL1A1 gene in stably transfected HT1080 cells: the production of a thermostable homotrimer of type I collagen in a recombinant system.

D. Prockop, A. Geddis, 1993, Matrix.

Kinetics for the secretion of nonhelical procollagen by freshly isolated tendon cells.

W. Kao, D. Prockop, R. Berg, 1979, The Journal of biological chemistry.

Perspectives on the synthesis and application of triple-helical, collagen-model peptides.

D. Prockop, G. Fields, Gregg B. Fields, 1996, Biopolymers.

Expression of a human cartilage procollagen gene (COL2A1) in mouse 3T3 cells.

S. Jimenez, L. Ala‐Kokko, K. Kivirikko, 1991, The Journal of biological chemistry.

High levels of expression of a minigene version of the human pro alpha 1 (I) collagen gene in stably transfected mouse fibroblasts. Effects of deleting putative regulatory sequences in the first intron.

A. Olsen, D. Prockop, A. Geddis, 1991, The Journal of biological chemistry.

Mitochondria to the rescue

D. Prockop, 2012, Nature Medicine.

Specific inhibition of expression of a human collagen gene (COL1A1) with modified antisense oligonucleotides

D. Prockop, A. Colige, Z. Lu, 1994 .

Ascorbate increases the synthesis of procollagen hydroxyproline by cultured fibroblasts from chick embryo tendons without activation of prolyl hydroxyla.

W. Kao, D. Prockop, R. Berg, 1975, Biochimica et biophysica acta.

Biosynthesis of abnormal collagens with amino acid analogues. II. Inability of cartilage cells to extrude collagen polypeptides containing L-azetidine-2-carboxylic acid or cis-4-fluoro-L-proline.

J. Rosenbloom, D. Prockop, T. Takeuchi, 1969, Biochimica et biophysica acta.

Rapidly Self-Renewing Human Multipotent Marrow Stromal Cells (hMSC) Express Sialyl Lewis X and Actively Adhere to Arterial Endothelium in a Chick Embryo Model System

D. Prockop, Miriam V. Gutschow, S. Olson, 2014, PloS one.

Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome

K. Kain, W. Liles, D. Prockop, 2014, BMC Immunology.

Structure of the Organic Matrix: Collagen Structure (Chemical)

D. Prockop, C. Williams, 1982 .

Enzymatic synthesis of hydroxyproline by the hydroxylation of poly(L-propyl-glycyl-L-prolyl).

J. Engel, D. Prockop, K. Juva, 1967, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

Proline analogue removes fibroblasts from cultured mixed cell populations

W. Kao, D. Prockop, DARWIN J. PROCKOP, 1977, Nature.

A fourth example suggests that premature termination codons in the COL2A1 gene are a common cause of the Stickler syndrome: analysis of the COL2A1 gene by denaturing gradient gel electrophoresis.

K. Kivirikko, D. Prockop, J. Hyland, 1993, Genomics.

Isolation of a Highly Clonogenic and Multipotential Subfraction of Adult Stem Cells from Bone Marrow Stroma

R. Pochampally, D. Prockop, Anthony S. Perry, 2004, Stem cells.

Recombinant Procollagen II: Deletion of D Period Segments Identifies Sequences That Are Required for Helix Stabilization and Generates a Temperature-sensitive N-Proteinase Cleavage Site*

D J Prockop, A. Sieron, D. Prockop, 1998, The Journal of Biological Chemistry.

A recombinant homotrimer of type I procollagen that lacks the central two D-periods. The thermal stability of the triple helix is decreased by 2 to 4 degrees C.

H. Kuivaniemi, G. Tromp, A. Sieron, 1997, Matrix biology : journal of the International Society for Matrix Biology.

New targets for osteoporosis.

D. Prockop, 2012, The New England journal of medicine.

Five families with arginine519‐cysteine mutation in COL2A1: Evidence for three distinct founders

R. Moskowitz, M. Devoto, D. Prockop, 1998, Human mutation.

G to A polymorphism in exon 45 of the COL1A1 gene.

B. Sokolov, D. Prockop, C. Constantinou, 1991, Nucleic acids research.

Efficient DNA sequencing on microtiter plates using dried reagents and Bst DNA polymerase.

H. Kuivaniemi, G. Tromp, D. Prockop, 1993, DNA sequence : the journal of DNA sequencing and mapping.

The biosynthesis of collagen. 3.

D. Prockop, M. E. Grant, 1972, New England Journal of Medicine.

Structure of the Human Type IV Collagen Genes a

D. Prockop, K. Tryggvason, R. Soininen, 1990, Annals of the New York Academy of Sciences.

Characterization of human type II procollagen and collagen-specific antibodies and their application to the study of human type II collagen processing and ultrastructure.

S. Jimenez, G. R. Dodge, D. Prockop, 1997, Matrix biology : journal of the International Society for Matrix Biology.

Tissue-specific Expression of the Gene for Type I Procollagen (COL1A1) in Transgenic Mice

B. Sokolov, D. Prockop, J. Khillan, 1995, The Journal of Biological Chemistry.

Further proof for an unpopular concept: a single cell from bone marrow can serve as a stem cell for both hematopoiesis and osteogenesis.

D. Prockop, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Stem Cell Research Has Only Just Begun

D. Prockop, D. Prockop, Darwin J. Prockop, 2001, Science.

Targeted disruption of Col11a2 produces a mild cartilage phenotype in transgenic mice: Comparison with the human disorder otospondylomegaepiphyseal dysplasia (OSMED)

D. Prockop, A. Maier, R. Mayne, 2001, Developmental dynamics : an official publication of the American Association of Anatomists.

Ehlers-Danlos type VIIC in human and dermatosparaxis in cattle are caused by mutations in the procollagen i amino-peptidase gene

P. Byers, A. Sieron, D. Prockop, 1998 .

Characterization of type I procollagen N-proteinase from fetal bovine tendon and skin. Purification of the 500-kilodalton form of the enzyme from bovine tendon.

J. Engel, D. Prockop, M. Mörgelin, 1994, The Journal of biological chemistry.

A rapid and simple PCR-based method for isolation of cDNAs from differentially expressed genes.

D J Prockop, B. Sokolov, D. Prockop, 1994, Nucleic acids research.

Mutation in the COL2A1 gene in a patient with hypochondrogenesis. Expression of mutated COL2A1 gene is accompanied by expression of genes for type I procollagen in chondrocytes.

D. Prockop, R. Bouvier, P. Freisinger, 1994, The Journal of biological chemistry.

Mutations that alter the primary structure of type I procollagen have long-range effects on its cleavage by procollagen N-proteinase.

D. Prockop, B. Vogel, K. E. Dombrowski, 1989, Biochemistry.

Substitutions for glycine alpha 1-637 and glycine alpha 2-694 of type I procollagen in lethal osteogenesis imperfecta. The conformational strain on the triple helix introduced by a glycine substitution can be transmitted along the helix.

D. Prockop, C. Constantinou, T. Tsuneyoshi, 1991, Journal of Biological Chemistry.

Heritable osteoarthritis. Diagnosis and possible modes of cell and gene therapy.

D. Prockop, 1999, Osteoarthritis and cartilage.

Erratum: Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice (Proceedings of the National Academy of Sciences of the United States of America (December 13, 2005) 102, 50 (18171-18176) DOI: 10.1073/pnas.0508945102)

D. Prockop, Jeffrey L. Spees, Andrew P Robinson, 2006 .

What holds us together? Why do some of us fall apart? What can we do about it?

D. Prockop, D. J. Prockop, 1998, Matrix biology : journal of the International Society for Matrix Biology.

Self-assembly into fibrils of collagen II by enzymic cleavage of recombinant procollagen II. Lag period, critical concentration, and morphology of fibrils differ from collagen I.

A. Sieron, D. Prockop, A. Fertala, 1994, The Journal of biological chemistry.

Cleavage of type I procollagen by C- and N-proteinases is more rapid if the substrate is aggregated with dextran sulfate or polyethylene glycol.

D. Prockop, Y. Hojima, A. M. Romanic, 1994, Analytical biochemistry.

Cleavage of type I and type II procollagens by type I/II procollagen N-proteinase. Correlation of kinetic constants with the predicted conformations of procollagen substrates.

D. Prockop, K. E. Dombrowski, Darwin J. Prockop, 1988, The Journal of biological chemistry.

Kinetics for the secretion of procollagen by freshly isolated tendon cells.

R A Berg, D J Prockop, W. Kao, 1977, The Journal of biological chemistry.

First-stage autosomal genome screen in extended pedigrees suggests genes predisposing to low bone mineral density on chromosomes 1p, 2p and 4q

J. Ott, M. Devoto, L. Ala‐Kokko, 1998, European Journal of Human Genetics.

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.

D. Prockop, F. Marini, A. Keating, 2006, Cytotherapy.

Partial rescue of a lethal phenotype of fragile bones in transgenic mice with a chimeric antisense gene directed against a mutated collagen gene.

D. Prockop, S. W. Li, J. Khillan, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of scar formation by the proline analog cis-hydroxyproline.

D. Prockop, J. Black, J. Lane, 1973, Journal of Surgical Research.

Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo. II. Morphological and physical properties of collagen containing the analogue.

D. Prockop, J. Lane, L. J. Parkes, 1971, Biochimica et Biophysica Acta.

Type I procollagen N-proteinase from whole chick embryos. Cleavage of a homotrimer of pro-alpha 1(I) chains and the requirement for procollagen with a triple-helical conformation.

D. Prockop, K. Tanzawa, J. Berger, 1985, The Journal of biological chemistry.

cells from bone marrow stroma

D. Prockop, Jeffrey L. Spees, S. Olson, 2016 .

Time to end the stem cell wars

D. Prockop, 2004 .

A point mutation in a type I procollagen gene converts glycine 748 of the alpha 1 chain to cysteine and destabilizes the triple helix in a lethal variant of osteogenesis imperfecta.

D. Prockop, B. Vogel, R. Minor, 1987, The Journal of biological chemistry.

Mutations in type I procollagen genes : an explanation for brittle bones and a paradigm for other diseases of connective tissue

D. Prockop, 1990 .

An ultrastructural, microanalytical, and spectroscopic study of bone from a transgenic mouse with a COL1.A1 pro-alpha-1 mutation.

D. Prockop, J. Cassella, J. Khillan, 1994, Bone.

Somatic cell mosaicism: another source of phenotypic heterogeneity in nuclear families with osteogenesis imperfecta.

D. Prockop, R. Ladda, C. Constantinou‐Deltas, 1993, American journal of medical genetics.

Transgenic Mice Expressing a Partially

H. Helminen, D. Prockop, E. Hume, 2013 .

Transgenic mice that express a mini-gene version of the human gene for type I procollagen (COL1A1) develop a phenotype resembling a lethal form of osteogenesis imperfecta.

A. Olsen, D. Prockop, S. Kontusaari, 1991, Journal of Biological Chemistry.

A long-awaited discovery: hypoxia prevents mouse cells from undergoing spontaneous p53-dependent transformation.

D. Prockop, 2012, Cytotherapy.

Mesenchymal Stem Cells. Methods and Protocols.

D. Prockop, B. Bunnell, D. Phinney, 2010, Anticancer research.

[Biosynthesis of collagen and its disorders].

K. Kivirikko, D. Prockop, L. Tuderman, 1979, Duodecim; laaketieteellinen aikakauskirja.

Procollagen polypeptides containing cis-4-hydroxy-L-proline are overglycosylated and secreted as nonhelical pro-gamma-chains.

W. Kao, J. Uitto, D. Prockop, 1978, Archives of biochemistry and biophysics.

Demonstration by immunofluorescence that the same cells from chick embryo aortas synthesize elastin and collagen types I and III.

W. Kao, S. Gay, D. Prockop, 1980, Artery.

Transgenic mice with inactivation of the COL11A2 gene demonstrate a minimal cartilage phenotype at birth and at 7 months

D. Prockop, R. Mayne, J. Khillan, 1996 .

A human COL2A1 gene with an Arg519Cys mutation causes osteochondrodysplasia in transgenic mice.

H. Helminen, D. Prockop, M. Lammi, 2004, Arthritis and rheumatism.

Single basemutation inthetypeIIprocollagen gene(COL2AI) asa causeofprimary osteoarthritis associated witha mildchondrodysplasia

C. Baldwin, D. Prockop, 1990 .

A HindIII polymorphism in the 3' end of the human alpha 1(IV) collagen gene

L. Tikka, K. Roiko, R. Soininen, 1987, Nucleic Acids Res..

Collagen fibrils in vitro grow from pointed tips in the C- to N-terminal direction.

K. Kadler, D. Prockop, Y. Hojima, 1990, The Biochemical journal.

Identification of COL2A1 gene mutations in patients with chondrodysplasias and familial osteoarthritis.

I. Kaitila, M. Vikkula, B. Sokolov, 1995, Arthritis and rheumatism.

Conservation of the sizes of 53 introns and over 100 intronic sequences for the binding of common transcription factors in the human and mouse genes for type II procollagen (COL2A1).

E. Vuorio, K. Kivirikko, D. Prockop, 1995, Biochemical Journal.

Spondyloepiphyseal dysplasia and precocious osteoarthritis in a family with an Arg75→Cys mutation in the procollagen type II gene (COL2A1)

S. Jimenez, D. Prockop, R. Knowlton, 1993, Human Genetics.

Crystal induced inflammation in canine joints. 3. Evidence against bradykinin as a mediator of inflammation.

D. Mccarty, D. Prockop, P. Phelps, 1966, The Journal of laboratory and clinical medicine.

Two improved methods for preparing ferritin-protein conjugates for electron microscopy

B. Olsen, D. Prockop, R. Berg, 1975, The Journal of cell biology.

A cDNA cassette system for the synthesis of recombinant procollagens. Variants of procollagen II lacking a D-period are secreted as triple-helical monomers.

A. Sieron, D. Prockop, A. Fertala, 1997, Matrix biology : journal of the International Society for Matrix Biology.

Use of R-loop mapping for the assessment of human collagen mutations.

G. Tromp, D. Prockop, M. Chu, 1986, The Journal of biological chemistry.

Molecular basis of osteogenesis imperfecta and related disorders of bone.

H. Kuivaniemi, G. Tromp, D. Prockop, 1994, Clinics in Plastic Surgery.

Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation.

D. Prockop, Joo Youn Oh, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

A subset of human rapidly self-renewing marrow stromal cells preferentially engraft in mice.

R. Pochampally, D. Prockop, J. Jung, 2006, Blood.

An official American Thoracic Society workshop report: stem cells and cell therapies in lung biology and diseases.

D. Prockop, P. Lelkes, D. Kotton, 2015, Annals of the American Thoracic Society.

Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury

D. Prockop, J. Oh, Hosoon Choi, 2010, Proceedings of the National Academy of Sciences.

Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-α-induced protein 6

J. Lasky, D. Welsh, D. Prockop, 2011, Stem Cell Research & Therapy.

A Homozygous Frameshift Mutation in the Pro‐α2(I) Collagen COOH‐Propeptide Results in Osteogenesis Imperfecta

T. Pihlajaniemi, D. Prockop, J. Myers, 1985 .

A subtle disease and a dilemma: can cells secrete collagen that does not contain a sugar-tag?

D. Prockop, 1972, The New England journal of medicine.

Medical therapies with adult stem/progenitor cells (MSCs): A backward journey from dramatic results in vivo to the cellular and molecular explanations

D. Prockop, J. Oh, 2012, Journal of cellular biochemistry.

Conformation-sensitive gel electrophoresis for rapid detection of single-base differences in double-stranded PCR products and DNA fragments: evidence for solvent-induced bends in DNA heteroduplexes.

D. Prockop, M. Rock, A. Ganguly, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Perspectives on the Synthesis and Application of Triple‐Helical, Collagen‐Model Peptides

D. Prockop, G. Fields, 2010 .

A Transport Form of Collagen from Embryonic Tendon: Electron Microscopic Demonstration of an NH2-Terminal Extension and Evidence Suggesting the Presence of Cystine in the Molecule

Darwin J. Prockop, Bjorn R. Olsen, S. Jimenez, 1972 .

iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers

D. Prockop, R. Reger, J. Xu, 2017, Cell Death Discovery.