D. Crommelin

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IN VITRO RELEASE STUDIES ON DRUGS SUSPENDED IN NON-POLAR MEDIA II. THE RELEASE OF PARACETAMOL AND CHLORAMPHENICOL FROM SUSPENSIONS IN LIQUID PARAFFIN

D. Crommelin, C. J. Blaey, 1980 .

Physical Methods to Characterize Pharmaceutical Proteins

Daan J.A. Crommelin, Wim Jiskoot, James N. Herron, 1995, Pharmaceutical Biotechnology.

Cellular Uptake of Cationic Polymer-DNA Complexes Via Caveolae Plays a Pivotal Role in Gene Transfection in COS-7 Cells

W. Hennink, R. Oosting, G. Koning, 2007, Pharmaceutical Research.

How to screen non-viral gene delivery systems in vitro?

Wim E Hennink, Enrico Mastrobattista, W. Hennink, 2011, Journal of controlled release : official journal of the Controlled Release Society.

Junk DNA enhances pEI-based non-viral gene delivery.

W. Hennink, R. Oosting, D. Crommelin, 2010, International journal of pharmaceutics.

An NLS peptide covalently linked to linear DNA does not enhance transfection efficiency of cationic polymer based gene delivery systems

D. Crommelin, W. Hennink, R. Oosting, 2005, The journal of gene medicine.

Cationic polymethacrylates with covalently linked membrane destabilizing peptides as gene delivery vectors.

C. van Nostrum, W. Hennink, D. Crommelin, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Design of methacrylate-based polyplexes for tumor targeting Review Article

W. Hennink, G. Storm, D. Crommelin, 2004 .

Association and Dissociation Characteristics of Polymer/DNA Complexes Used for Gene Delivery

W. Hennink, D. Crommelin, C. Arigita, 1999, Pharmaceutical Research.

Polymer Side-Chain Degradation as a Tool to Control the Destabilization of Polyplexes

C. van Nostrum, W. Hennink, D. Crommelin, 2004, Pharmaceutical Research.

Cationic polymers that enhance the performance of HbsAg DNA in vivo.

W. Hennink, D. Crommelin, G. Bos, 2004, Vaccine.

Long Term Stability of Poly((2-dimethylamino)ethyl Methacrylate)-Based Gene Delivery Systems

W. Hennink, D. Crommelin, J. Cherng, 1999, Pharmaceutical Research.

Effect of Size and Serum Proteins on Transfection Efficiency of Poly ((2-dimethylamino)ethyl Methacrylate)-Plasmid Nanoparticles

W. Hennink, D. Crommelin, J. Cherng, 1996, Pharmaceutical Research.

Water-soluble biodegradable cationic polyphosphazenes for gene delivery.

C. van Nostrum, W. Hennink, G. Koning, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Water-soluble cationic methacrylate polymers for nonviral gene delivery.

W. Hennink, D. Crommelin, G. Bos, 2001, Methods in molecular medicine.

Copolymers of 2-(dimethylamino)ethyl methacrylate with ethoxytriethylene glycol methacrylate or N-vinyl-pyrrolidone as gene transfer agents.

W. Hennink, D. Crommelin, M. V. van Steenbergen, 2000, Journal of controlled release : official journal of the Controlled Release Society.

Sterilization of poly(dimethylamino) ethyl methacrylate-based gene transfer complexes.

W. Hennink, W. Jiskoot, D. Crommelin, 2000, International journal of pharmaceutics.

Effects of Physicochemical Characteristics of Poly(2-(dimethylamino)ethyl methacrylate)-Based Polyplexes on Cellular Association and Internalization

W. Hennink, G. Storm, D. Crommelin, 2000, Journal of drug targeting.

2-(Dimethylamino)ethyl methacrylate based (co)polymers as gene transfer agents.

W. Hennink, D. Crommelin, J. Cherng, 1998, Journal of controlled release : official journal of the Controlled Release Society.

Artificial viruses: a nanotechnological approach to gene delivery

Wim E. Hennink, Enrico Mastrobattista, W. Hennink, 2006, Nature Reviews Drug Discovery.

DNA Nuclear Targeting Sequences for Non-Viral Gene Delivery

Wim E. Hennink, Enrico Mastrobattista, W. Hennink, 2011, Pharmaceutical Research.

Flow cytometry for rapid size determination and sorting of nucleic acid containing nanoparticles in biological fluids.

W. Hennink, D. Crommelin, E. Mastrobattista, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Conformation and intermolecular interactions of SA2 peptides self-assembled into vesicles.

W. Hennink, W. Jiskoot, D. Crommelin, 2010, The journal of physical chemistry. B.

Commentary: "A systems view on the future of medicine: inspiration from Chinese medicine?".

M. Danhof, R. Witkamp, J. van der Greef, 2009, Journal of ethnopharmacology.

Self-assembly of recombinant amphiphilic oligopeptides into vesicles.

W. Hennink, W. Jiskoot, D. Crommelin, 2007, Biomacromolecules.

CHAPTER 7.2 – Strategies for large scale production and optimized stability of pharmaceutical liposomes developed for parenteral use

D. Crommelin, N. Zuidam, E. Winden, 1998 .

Short term stability of freeze-dried, lyoprotected liposomes.

D. Crommelin, E. C. van Winden, 1999, Journal of controlled release : official journal of the Controlled Release Society.

On the structure of immune-stimulating saponin-lipid complexes (iscoms).

E. C. Beuvery, D. Crommelin, G. Kersten, 1991, Biochimica et biophysica acta.

Liposomes and ISCOMS as vaccine formulations.

D. Crommelin, G. Kersten, 1995, Biochimica et biophysica acta.

Liposomes and ISCOMs.

D. Crommelin, G. Kersten, 2003, Vaccine.

Long-term stability of liposomes containing both tissue-type plasminogen activator and glu-plasminogen

D. Crommelin, C. Kluft, J. Heeremans, 1996 .

Characterization of liposomes. The influence of extrusion of multilamellar vesicles through polycarbonate membranes on particle size, particle size distribution and number of bilayers

H. Junginger, D. Crommelin, H. Talsma, 1987 .

Therapeutic effect of chloroquine(CQ)-containing immunoliposomes in rats infected with Plasmodium berghei parasitized mouse red blood cells: comparison with combinations of antibodies and CQ or liposomal CQ.

D. Crommelin, W. Eling, P. Peeters, 1989, Biochimica et biophysica acta.

Chloroquine Blood Levels After Administration of the Liposome-Encapsulated Drug in Relation to Therapy of Murine Malaria

D. Crommelin, W. Eling, P. Peeters, 1989, Pharmaceutical Research.

Non-Biological Complex Drugs

Jon S. B. de Vlieger, Daan J.A. Crommelin, D. Crommelin, 2015, AAPS Advances in the Pharmaceutical Sciences Series.

Liposomes: The Science and the Regulatory Landscape

Gert Storm, Daan J.A. Crommelin, G. Storm, 2015 .

Formulation of Biotech Products, Including Biopharmaceutical Considerations

D. Crommelin, 2013 .

Towards more effective advanced drug delivery systems.

D. Crommelin, A. Florence, Daan J.A. Crommelin, 2013, International journal of pharmaceutics.

Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: essential need to use orthogonal methods to assure the quality of therapeutic protein products.

W. Jiskoot, G. Winter, C. R. Middaugh, 2010, Journal of pharmaceutical sciences.

Preclinical and Clinical In Vitro In Vivo Correlation of an hGH Dextran Microsphere Formulation

W. Hennink, D. Crommelin, R. Verrijk, 2007, Pharmaceutical Research.

Efficacy of pulmonary insulin delivery in diabetic rats: use of a model-based approach in the evaluation of insulin powder formulations.

W. Hennink, W. Jiskoot, D. Crommelin, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Stabilization of Proteins in Dry Powder Formulations Using Supercritical Fluid Technology

W. Jiskoot, D. Crommelin, G. Hofland, 2004, Pharmaceutical Research.

Dissolution rate of griseofulvin in bile salt solutions.

D. Crommelin, J. C. Offringa, J. D. de Smidt, 1991, Journal of pharmaceutical sciences.

A novel technique for the one-step preparation of liposomes and nonionic surfactant vesicles without the use of organic solvents. Liposome formation in a continuous gas stream: the 'bubble' method.

D. Crommelin, H. Talsma, M. J. van Steenbergen, 1994, Journal of pharmaceutical sciences.

Hydrolysis of saturated soybean phosphatidylcholine in aqueous liposome dispersions.

D. Crommelin, W. Underberg, M. Grit, 1993, Journal of pharmaceutical sciences.

Hydrolysis of Partially Saturated Egg Phosphatidylcholine in Aqueous Liposome Dispersions and the Effect of Cholesterol Incorporation on Hydrolysis Kinetics

D. Crommelin, N. Zuidam, W. Underberg, 1993, The Journal of pharmacy and pharmacology.

The effect of surface charge on the hydrolysis kinetics of partially hydrogenated egg phosphatidylcholine and egg phosphatidylglycerol in aqueous liposome dispersions.

D. Crommelin, M. Grit, 1993, Biochimica et biophysica acta.

The influence of the molar ratio of cholesteryl hemisuccinate/dipalmitoylphosphatidylcholine on 'liposome' formation after lipid film hydration.

J. Bouwstra, G. Gooris, D. Crommelin, 1992, Chemistry and physics of lipids.

Hydrolysis of phosphatidylcholine in aqueous liposome dispersions

D. Crommelin, M. Grit, J. Smidt, 1989 .

The Size Reduction of Liposomes with a High Pressure Homogenizer (Microfluidizer™). Characterization of Prepared Dispersions and Comparison with Conventional Methods.

D. Crommelin, H. Talsma, L. Bloois, 1989 .

Liposome encapsulation of doxorubicin: Pharmaceutical and therapeutic aspects

G. Storm, D. Crommelin, L. Bloois, 1989 .

Influence of lipid composition and ionic strength on the physical stability of liposomes.

D. Crommelin, 1984, Journal of pharmaceutical sciences.

C. Ronco, B. Strukelj, D. Crommelin, 2005, Contributions to nephrology.

Chapter 6 Structural characterization and immunogenicity in wildtype and immune tolerant mice of degraded recombinant human interferon alpha 2 b

M. Slijper, W. Jiskoot, D. Crommelin, 2005 .

Shifting paradigms: biopharmaceuticals versus low molecular weight drugs.

W. Hennink, W. Jiskoot, G. Storm, 2003, International journal of pharmaceutics.

In vitro release studies on drugs suspended in non-polar media I. Release of sodium chloride from suspensions in liquid paraffin

D. Crommelin, C. J. Blaey, 1980 .

Assuring quality and performance of sustained and controlled released parenterals.

A. Hussain, D. Crommelin, D. Burgess, 2004, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

In vitro release studies on drugs suspended in non-polar media

D. Crommelin, 1980, Pharmaceutisch Weekblad.

A mechanistic study on the chemical and enzymatic degradation of PEG‐Oligo(ε‐caprolactone) micelles

W. Hennink, D. Crommelin, R. Verrijk, 2008 .

Reduced cardiotoxicity and nephrotoxicity with preservation of antitumor activity of doxorubicin entrapped in stable liposomes in the LOU/M Wsl rat.

D. Crommelin, P. Steerenberg, A. van Dijk, 1984, Cancer research.

LIPOSOME-BASED CANCER VACCINES

D. Crommelin, W. Otter, J. J. Bergers, 1996 .

The Pharmaceutical Sciences in 2020: Report of a Conference Organized by the Board of Pharmaceutical Sciences of the International Pharmaceutical Federation (FIP)

G. Tucker, V. Shah, D. Crommelin, 2010, Pharmaceutical Research.

Antibody-Targeted Liposomes to Deliver Doxorubicin to Ovarian Cancer Cells

G. Storm, D. Crommelin, M. Vingerhoeds, 1994 .

Fourier transform infrared spectrometric analysis of protein conformation: effect of sampling method and stress factors.

W. Hennink, P. Haris, D. Crommelin, 2001, Analytical biochemistry.

Sterilization of Liposomes by Heat Treatment

D. Crommelin, N. Zuidam, Nicolaas J. Zuidam, 1993, Pharmaceutical Research.

Hydrolysis of Phospholipids in Liposomes and Stability- Indicating Analytical Techniques

D. Crommelin, N. Zuidam, 2016 .

Stability of doxorubicin-liposomes on storage: as an aqueous dispersion, frozen or freeze-dried

D. Crommelin, E. V. Bommel, 1984 .

Determination of phosphatidylcholine phosphatidylglycerol and their lyso forms from liposome dispersions by high performance liquid chromatography using high sensitivity refractive index detection

D. Crommelin, M. Grit, J. Lang, 1991 .

The use of aqueous PEG/dextran phase separation for the preparation of dextran microspheres.

W. Hennink, D. Crommelin, R. Stenekes, 1999, International journal of pharmaceutics.

Addressing the Cold Reality of mRNA Vaccine Stability

W. Jiskoot, D. Volkin, T. Anchordoquy, 2020, Journal of Pharmaceutical Sciences.

Physicochemical and immunochemical techniques predict the quality of diphtheria toxoid vaccines.

W. Hennink, W. Jiskoot, D. Crommelin, 2003, Vaccine.

Development of a Transgenic Mouse Model Immune Tolerant for Human Interferon Beta

W. Jiskoot, D. Crommelin, H. Schellekens, 2005, Pharmaceutical Research.

Shifting paradigms revisited: biotechnology and the pharmaceutical sciences.

W. Jiskoot, D. Crommelin, E. Mastrobattista, 2020, Journal of pharmaceutical sciences.

Degradable dextran microspheres for the controlled release of liposomes.

W. Hennink, D. Crommelin, R. Stenekes, 2001, International journal of pharmaceutics.

Steric stabilization of poly(2‐(dimethylamino)ethyl methacrylate)‐based polyplexes mediates prolonged circulation and tumor targeting in mice

D. Crommelin, W. Hennink, G. Storm, 2004, The journal of gene medicine.

Freeze-Drying of Poly((2-dimethylamino)ethyl Methacrylate)-Based Gene Delivery Systems

W. Hennink, D. Crommelin, J. Cherng, 1997, Pharmaceutical Research.

PEG shielded polymeric double-layered micelles for gene delivery.

C. van Nostrum, W. Hennink, G. Koning, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines

Y. Barenholz, G. Storm, D. Crommelin, 2022, Nature Nanotechnology.

Immunoliposomes in vivo: state of the art

G. Storm, D. Crommelin, P. Peeters, 1988 .

Characterization and Modulation of the Transferrin Receptor on Brain Capillary Endothelial Cells

M. Danhof, D. Crommelin, A. G. de Boer, 2004, Pharmaceutical Research.

Postproduction Handling and Administration of Protein Pharmaceuticals and Potential Instability Issues.

W. Jiskoot, D. Volkin, D. Crommelin, 2018, Journal of pharmaceutical sciences.

Equivalence of complex drug products: advances in and challenges for current regulatory frameworks

Gerrit Borchard, Scott McNeil, Beat Flühmann, 2017, Annals of the New York Academy of Sciences.

The EU regulatory landscape of non‐biological complex drugs (NBCDs) follow‐on products: Observations and recommendations

H. Leufkens, M. D. De Bruin, D. Crommelin, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Report of the AAPS Guidance Forum on the FDA Draft Guidance for Industry: “Drug Products, Including Biological Products, that Contain Nanomaterials”

Rachael M. Crist, V. Shah, D. Crommelin, 2019, The AAPS Journal.

N-trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: biological properties and immunogenicity in a mouse model.

H. Junginger, W. Jiskoot, D. Crommelin, 2007, Vaccine.

Diphtheria toxoid-containing microparticulate powder formulations for pulmonary vaccination: preparation, characterization and evaluation in guinea pigs.

W. Hennink, W. Jiskoot, D. Crommelin, 2007, Vaccine.

Reflections on the Future of Pharmaceutical Public-Private Partnerships: From Input to Impact

D. Crommelin, R. D. de Vrueh, 2017, Pharmaceutical Research.

Targeting liposomes with protein drugs to the blood-brain barrier in vitro.

Meindert Danhof, Sanja Stevanović, M. Danhof, 2005, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Superoxide dismutase entrapped in long-circulating liposomes: formulation design and therapeutic activity in rat adjuvant arthritis.

D. Crommelin, G. Storm, D. Crommelin, 2002, Biochimica et biophysica acta.

TARGETED LIPOSOMES FOR DELIVERY OF PROTEIN-BASED DRUGS INTO THE CYTOPLASM OF TUMOR CELLS

G. Storm, D. Crommelin, E. Mastrobattista, 2002, Journal of liposome research.

Coupling of Metal Containing Homing Devices to Liposomes via a Maleimide Linker: Use of TCEP to Stabilize Thiol-groups without Scavenging Metals

M. Danhof, D. Crommelin, A. G. de Boer, 2004, Journal of drug targeting.

Validation of the Transferrin Receptor for Drug Targeting to Brain Capillary Endothelial Cells In Vitro

M. Danhof, D. Crommelin, P. Gaillard, 2004, Journal of drug targeting.

Identification of formaldehyde-induced modifications in diphtheria toxin.

W. Hennink, W. Jiskoot, Maarten Danial, 2020, Journal of pharmaceutical sciences.

Lymphatic Uptake and Biodistribution of Liposomes after Subcutaneous Injection I. Influence of the Anatomical Site of Injection

G. Storm, D. Crommelin, C. Oussoren, 1997 .

Incorporation of the major outer membrane protein of Neisseria gonorrhoeae in saponin-lipid complexes (iscoms): chemical analysis, some structural features, and comparison of their immunogenicity with three other antigen delivery systems

E. C. Beuvery, D. Crommelin, A. Verkleij, 1988, Infection and immunity.

Intestinal absorption of drugs. I: The influence of taurocholate on the absorption of dantrolene in the small intestine of the rat.

D. Crommelin, F. Poelma, J. Tukker, 1989, Journal of pharmaceutical sciences.

Preparation and characterization of liposomes with incorporated Neisseria gonorrhoeae protein ib and amphiphilic adjuvants

E. C. Beuvery, F. Dalen, D. Crommelin, 1988 .

Immunogenic activity of gonococcal protein I in mice with three different lipoidal adjuvants delivered in liposomes and in complexes

E. C. Beuvery, W. Jiskoot, D. Crommelin, 1986, Infection and immunity.

Controlled Release of Octreotide and Assessment of Peptide Acylation from Poly(D,L-lactide-co-hydroxymethyl glycolide) Compared to PLGA Microspheres

C. van Nostrum, W. Hennink, R. Kok, 2011, Pharmaceutical Research.

Preparation and application of a fluorescein-labeled peptide for determining the affinity constant of a monoclonal antibody-hapten complex by fluorescence polarization.

E. C. Beuvery, W. Jiskoot, D. Crommelin, 1991, Analytical biochemistry.

The role of protein charge in protein-lipid interactions. pH-dependent changes of the electrophoretic mobility of liposomes through adsorption of water-soluble, globular proteins.

D. Crommelin, J. Herron, M. Vingerhoeds, 1993, Biochemistry.

Interleukin-2-Containing Liposomes: Interaction of Interleukin-2 with Liposomal Bilayers and Preliminary Studies on Application in Cancer Vaccines

D. Crommelin, W. Otter, H. Dullens, 2004, Pharmaceutical Research.

The preparation of tissue-type Plasminogen Activator (t-PA) containing liposomes: entrapment efficiency and ultracentrifugation damage.

D. Crommelin, C. Kluft, J. Heeremans, 1995, Journal of drug targeting.

The fate of poly(2-dimethyl amino ethyl)methacrylate-based polyplexes after intravenous administration.

M. Hashida, G. Storm, D. Crommelin, 2001, International journal of pharmaceutics.

Multi-antigen immunization using IgG binding domain ZZ as carrier.

Yair Benita, W. Hennink, W. Jiskoot, 2005, Vaccine.

Immunoliposomes bearing enzymes (immuno-enzymosomes) for site-specific activation of anticancer prodrugs

G. Storm, D. Crommelin, M. Vingerhoeds, 1997 .

Immunoliposome-Mediated Delivery of Chemotherapeutics

G. Storm, D. Crommelin, P. Steerenberg, 1990 .

Dissolution kinetics of griseofulvin in mixed micellar solutions.

D. Crommelin, J. D. de Smidt, M. Grit, 1994, Journal of pharmaceutical sciences.

Chemical stability of liposomes: implications for their physical stability.

D. Crommelin, M. Grit, 1993, Chemistry and physics of lipids.

Treatment of Tumors Using Cytostatic-containing Liposomes

P. Steerenberg, G. Storm, D. Crommelin, 1991 .

Regulatory Framework for Biosimilars

V. Shah, D. Crommelin, 2013 .

Delivery of biologicals: the wish list is long…

D. Crommelin, 2004, Expert opinion on drug delivery.

Preparation of clinical grade monoclonal antibodies from serum-containing cell culture supernatants.

E. C. Beuvery, W. Jiskoot, D. Crommelin, 1991, JIM - Journal of Immunological Methods.

THERAPEUTIC INDEX OF GLUCOCORTICOIDS CAN BE OPTIMIZED BY ENCAPSULATING HIGH-CLEARANCE GLUCOCORTICOIDS IN LONG-CIRCULATING LIPOSOMES

G. Storm, D. Crommelin, L. Bloois, 2003 .

Gamma-irradiation damage to liposomes differing in composition and their protection by nitroxides.

Y. Barenholz, D. Crommelin, N. Zuidam, 1997, Free radical biology & medicine.

Preparation and characterization of doxorubicin-containing liposomes. II. Loading capacity, long-term stability and doxorubicin-bilayer interaction mechanism

D. Crommelin, L. Bloois, 1983 .

Stability of Liposomes on Storage: Freeze Dried, Frozen or as an Aqueous Dispersion

D. Crommelin, E. M. V. van Bommel, 1984, Pharmaceutical Research.

Restored functional immunogenicity of purified meningococcal PorA by incorporation into liposomes.

W. Hennink, W. Jiskoot, D. Crommelin, 2003, Vaccine.

Induction of T Cell Anergy by Liposomes with Incorporated Major Histocompatibility Complex (MHC) II/Peptide Complexes

W. van Eden, M. Wauben, D. Crommelin, 2000, Pharmaceutical Research.

Liposomes with Incorporated MHC Class Il/Peptide Complexes as Antigen Presenting Vesicles for Specific T Cell Activation

W. van Eden, M. Wauben, D. Crommelin, 1999, Pharmaceutical Research.

Stability of mono- and trivalent meningococcal outer membrane vesicle vaccines.

W. Hennink, W. Jiskoot, D. Crommelin, 2004, Vaccine.

Reversible aggregation of lysozyme in a biodegradable amphiphilic multiblock copolymer.

W. Hennink, D. Crommelin, M. van de Weert, 2002, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Equivalence of glatiramer acetate products: challenges in assessing pharmaceutical equivalence and critical clinical performance attributes

D. Crommelin, G. Borchard, 2018, Expert opinion on drug delivery.

Chapter 7 Identification of formaldehyde-induced modifications in proteins : reactions with diphtheria toxin

D. Crommelin, B. Metz, 2007 .

Identi ﬁ cation of Formaldehyde-Induced Modi ﬁ cations in Diphtheria Toxin

W. Hennink, W. Jiskoot, Maarten Danial, 2019 .

Cells Involved in Removing Liposomes from the Blood Circulation: Why Are They So Special?

D. Crommelin, G. Scherphof, 1996 .

Quality control of routine, experimental and real-time aged diphtheria toxoids by in vitro analytical techniques.

W. Hennink, W. Jiskoot, D. Crommelin, 2007, Vaccine.

Stability of coarse suspensions in nonpolar media: Effect of gravity on the interaction between particles

D. Crommelin, P. Wiersema, P. H. Wiersema, 1984 .

Characterization of flocs in coarse suspensions in a non-polar medium

D. Crommelin, C. J. Blaey, P. V. Mil, 1984 .

Supercritical fluid drying of carbohydrates: selection of suitable excipients and process conditions.

W. Jiskoot, D. Crommelin, G. Hofland, 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Absorption of Etoposide (VP-16-213) from the Small Intestine of the Rat. The Potential Role of Mucus as an Absorption Rate Limiting Barrier

D. Crommelin, C. J. de Blaey, N. Schurgers, 1985, Pharmaceutical Research.

Intestinal Absorption of Drugs. The Influence of Mixed Micelles on on the Disappearance Kinetics of Drugs from the Small Intestine of the Rat

D. Crommelin, D. Crommelin, F. Poelma, 1991, The Journal of pharmacy and pharmacology.

Two-step purification of a murine monoclonal antibody intended for therapeutic application in man. Optimisation of purification conditions and scaling up.

E. C. Beuvery, W. Jiskoot, D. Crommelin, 1989, Journal of immunological methods.

On the interaction between a bactericidal antibody and a PorA epitope of Neisseria meningitidis in outer membrane vesicles: a competitive fluorescence polarization immunoassay.

D. Crommelin, J. Herron, J. Poolman, 1997, Analytical biochemistry.

Stabilization of IgG by supercritical fluid drying: optimization of formulation and process parameters.

W. Jiskoot, D. Crommelin, G. Hofland, 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Well-defined and potent liposomal meningococcal B vaccines adjuvated with LPS derivatives.

W. Hennink, W. Jiskoot, D. Crommelin, 2005, Vaccine.

Immunogenicity of meningococcal PorA formulations encapsulated in biodegradable microspheres.

W. Hennink, W. Jiskoot, D. Crommelin, 2004, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Targeting with IgG and Immunoliposomes to Circulating Cells: The ‘Target Cell Dragging’ Concept

D. Crommelin, W. Eling, P. Peeters, 1992 .

Unwanted Interactions of Maleimidophenylbutyrate-Phosphatidylethanolamine Containing (Immuno) Liposomes with Cells In Vitro

D. Crommelin, W. Eling, C. Oussoren, 1989 .

Immunospecific targeting of liposomes to erythrocytes.

D. Crommelin, W. Eling, P. Peeters, 1988, Biochemical pharmacology.

Preparation and physicochemical characterization of supercritically dried insulin-loaded microparticles for pulmonary delivery.

W. Hennink, W. Jiskoot, D. Crommelin, 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Chloroquine containing liposomes in the chemotherapy of murine malaria

D. Crommelin, W. Eling, P. Peeters, 1989, Parasitology.

Preparation and characterization of folate-targeted pEG-coated pDMAEMA-based polyplexes.

D. Crommelin, G. Storm, D. Crommelin, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Immunogenicity of liposomes and iscoms containing the major outer membrane protein of Neisseria gonorrhoeae: influence of protein content and liposomal bilayer composition

E. C. Beuvery, D. Crommelin, G. Kersten, 1988, Infection and immunity.

Immunospecific targeting of immunoliposomes, F(ab')2 and IgG to red blood cells in vivo.

D. Crommelin, W. Eling, C. Oussoren, 1988, Biochimica et biophysica acta.

Poly(3-guanidinopropyl methacrylate): a novel cationic polymer for gene delivery.

C. van Nostrum, W. Hennink, D. Crommelin, 2004, Bioconjugate chemistry.

Endosomal escape of polymeric gene delivery complexes is not always enhanced by polymers buffering at low pH.

C. van Nostrum, W. Hennink, G. Koning, 2004, Biomacromolecules.

Effect of Freezing Rate on the Stability of Liposomes During Freeze-Drying and Rehydration

Wei Zhang, D. Crommelin, E. C. van Winden, 1997, Pharmaceutical Research.

Enhanced permeability of freeze-dried liposomal bilayers upon rehydration.

J. Bouwstra, D. Crommelin, E. C. van Winden, 1997, Cryobiology.

The cryopreservation of liposomes. 2. Effect of particle size on crystallization behavior and marker retention.

D. Crommelin, H. Talsma, M. J. van Steenbergen, 1992, Cryobiology.

The cryopreservation of liposomes: 3. Almost complete retention of a water-soluble marker in small liposomes in a cryoprotectant containing dispersion after a freezing/thawing cycle

D. Crommelin, H. Talsma, M. J. Steenbergen, 1991 .

Liposomes and immunoliposomes for controlled release or site specific delivery of anti-parasitic drugs and cytostatics

P. Steerenberg, G. Storm, D. Crommelin, 1991 .

Preparation and characterization of doxorubicin-containing liposomes: I. Influence of liposome charge and pH of hydration medium on loading capacity and particle size

D. Crommelin, L. Bloois, N. Slaats, 1983 .

Poly(ethylene glycol)--oligolactates with monodisperse hydrophobic blocks: preparation, characterization, and behavior in water.

C. van Nostrum, W. Hennink, D. Crommelin, 2005, Langmuir : the ACS journal of surfaces and colloids.

The effect of a water/organic solvent interface on the structural stability of lysozyme.

W. Hennink, D. Crommelin, M. van de Weert, 2000, Journal of controlled release : official journal of the Controlled Release Society.

ACTIVE TARGETING WITH PARTICULATE CARRIER SYSTEMS IN THE BLOOD COMPARTMENT

G. Storm, D. Crommelin, G. Scherphof, 1995 .

Doxorubicin induces aggregation of small negatively charged liposomes

D. Crommelin, M. Fonseca, E. Winden, 1997 .

Virosome and ISCOM vaccines against Newcastle disease: preparation, characterization and immunogenicity.

W. Jiskoot, D. Crommelin, G. Kersten, 2004, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Thermal analysis of freeze-dried liposome-carbohydrate mixtures with modulated temperature differential scanning calorimetry.

D. Crommelin, H. Talsma, E. C. van Winden, 1998, Journal of pharmaceutical sciences.

Long term stability of freeze-dried, lyoprotected doxorubicin liposomes

D. Crommelin, E. Winden, 1997 .

A gradient matrix system as a controlled release device. Release from a slab model system

D. Crommelin, E. V. Bommel, J. Fokkens, 1989 .

The Storage and In-Use Stability of mRNA Vaccines and Therapeutics: Not A Cold Case

D. Volkin, D. Crommelin, E. Mastrobattista, 2022, Journal of Pharmaceutical Sciences.

Treatment with recombinant human tumour necrosis factor-α reduces parasitaemia and prevents Plasmodium berghei K173-induced experimental cerebral malaria in mice

N. S. Postma, D. Crommelin, W. Eling, 1999, Parasitology.

Pharmaceutical nanotechnology: Unmet needs in drug delivery.

Kinam Park, D. Crommelin, A. Florence, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Liposomal Formulations to Reduce Irritation of Intramuscularly and Subcutaneously Administered Drugs

D. Crommelin, C. Oussoren, F. Kadir, 1999 .

Reflections on the Future of Pharmaceutical Public-Private Partnerships: From Input to Impact

D. Crommelin, R. D. de Vrueh, 2017, Pharmaceutical Research.

Controlled Release of Octreotide and Assessment of Peptide Acylation from Poly(D,L-lactide-co-hydroxymethyl glycolide) Compared to PLGA Microspheres

C. van Nostrum, W. Hennink, R. Kok, 2011, Pharmaceutical Research.

Effect of excipients on the encapsulation efficiency and release of human growth hormone from dextran microspheres.

W. Hennink, W. Jiskoot, D. Crommelin, 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Abstracts of papers

J. Greve, J. G. McVie, G. L. Scherphof, 2005, Pharmaceutisch Weekblad.

Conductivity and Debye Length in Aerosol‐OT Hexane/Liquid Paraffin Solutions

D. Crommelin, P. Wiersema, P. V. Mil, 1982 .

Dissolution of theophylline monohydrate and anhydrous theophylline in buffer solutions.

D. Crommelin, J. D. de Smidt, J. Fokkens, 1986, Journal of pharmaceutical sciences.

The role of liposomes in clinical nanomedicine development. What now? Now what?

Gert Storm, G. Storm, D. Crommelin, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Preparation of liposomes via detergent removal from mixed micelles by dilution

Wim Jiskoot, E. C. Beuvery, W. Jiskoot, 1986, Pharmaceutisch Weekblad.

Effect of the modifier on the particle formation and crystallisation behaviour during precipitation from aqueous solutions

W. Jiskoot, D. Crommelin, G. Hofland, 2008 .

Ways of manipulating the polymorphism of glycine during supercritical fluid crystallisation

W. Jiskoot, D. Crommelin, G. Hofland, 2008 .

Selective Production of Polymorphs and Pseudomorphs Using Supercritical Fluid Crystallization from Aqueous Solutions

W. Jiskoot, D. Crommelin, G. Hofland, 2007 .

Lysozyme particle formation during supercritical fluid drying: Particle morphology and molecular integrity

W. Jiskoot, D. Crommelin, G. Hofland, 2007 .

Distinct effects of sucrose and trehalose on protein stability during supercritical fluid drying and freeze-drying.

Geert-Jan Witkamp, Wim Jiskoot, W. Jiskoot, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Liposomal and Lipid Formulations of Amphotericin B

D. Crommelin, R. Janknegt, I. Bakker-Woudenberg, 1992, Clinical pharmacokinetics.

Assuring quality and performance of sustained and controlled release parenterals: EUFEPS workshop report

A. Hussain, D. Crommelin, D. Burgess, 2008, AAPS PharmSci.

Liposomes as intramuscular and subcutaneous injection drug delivery systems

D. Crommelin, J. Zuidema, F. Kadir, 1993 .

Chemical hydrolysis of phospholipids.

D. Crommelin, N. Zuidam, 1995, Journal of pharmaceutical sciences.

Physical (in) stability of liposomes upon chemical hydrolysis: the role of lysophospholipids and fatty acids.

Y. Barenholz, D. Crommelin, N. Zuidam, 1995, Biochimica et biophysica acta.

Antigen-expressing immunostimulatory liposomes as a genetically programmable synthetic vaccine

W. Hennink, D. Crommelin, M. de Raad, 2010, Systems and Synthetic Biology.

Micelle-Associated Protein in Epoetin Formulations: A Risk Factor for Immunogenicity?

Huub Schellekens, Wim Jiskoot, W. Jiskoot, 2003, Pharmaceutical Research.

Gamma-Irradiation of Non-Frozen, Frozen, and Freeze-Dried Liposomes

D. Crommelin, N. Zuidam, Stephen S. L. Lee, 1995, Pharmaceutical Research.

Critical parameters in freezing of liposomes

D. Crommelin, P. Salemink, G. J. Fransen, 1986 .

Structure-Immunogenicity Relationships of Therapeutic Proteins

Huub Schellekens, Wim Jiskoot, W. Jiskoot, 2004, Pharmaceutical Research.

A mechanistic study of the effects of the 1-alkyl-2-pyrrolidones on bilayer permeability of stratum corneum lipid liposomes: a comparison with hairless mouse skin studies.

D. Crommelin, S. K. Li, A. Ghanem, 1995, Journal of pharmaceutical sciences.

Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques.

R. Heeren, W. Hennink, D. Crommelin, 2000, Journal of controlled release : official journal of the Controlled Release Society.

The Influence of Sucrose, Dextran, and Hydroxypropyl-β-cyclodextrin as Lyoprotectants for a Freeze-Dried Mouse IgG2a Monoclonal Antibody (MN12)

Wim Jiskoot, E. C. Beuvery, E. Coen Beuvery, 1992, Pharmaceutical Research.

Doxorubicin decomposition on storage: effect of pH, type of buffer and liposome encapsulation

G. Storm, D. Crommelin, A. Hulshoff, 1985 .

Methods for structural analysis of protein pharmaceuticals

Daan J.A. Crommelin, Wim Jiskoot, W. Jiskoot, 2005 .

Ongoing challenges to develop high concentration monoclonal antibody-based formulations for subcutaneous administration: Quo Vadis?

W. Jiskoot, D. Volkin, D. Crommelin, 2021, Journal of pharmaceutical sciences.

Identification of Formaldehyde-induced Modifications in Proteins

W. Hennink, W. Jiskoot, D. Crommelin, 2004, Journal of Biological Chemistry.

mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability

W. Jiskoot, D. Crommelin, J. Kulkarni, 2021, International Journal of Pharmaceutics.

Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release.

Theodore W Randolph, C Russell Middaugh, Wim Jiskoot, 2012, Journal of pharmaceutical sciences.

Reconstituted membranes of tumour cells (proteoliposomes) induce specific protection to murine lymphoma cells

D. Crommelin, P. Steerenberg, W. Otter, 2005, Cancer Immunology, Immunotherapy.

Nanotechnological approaches for the delivery of macromolecules.

Wim E Hennink, Gert Storm, Daan J A Crommelin, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Application of Electrospray Mass Spectrometry (ES-MS) for the Analysis of Monoclonal Antibody Fc Subunits

E. C. Beuvery, W. Jiskoot, D. Crommelin, 1992, Pharmaceutical Research.

Assessment of biotechnology drugs: what are the issues?

D. Crommelin, H. Leufkens, F. Rutten, 1999, Health policy.

Non-random conformation of a mouse IgG2a monoclonal antibody at low pH.

E. C. Beuvery, W. Jiskoot, R. van Grondelle, 1991, European journal of biochemistry.

Formulation of cell-based medicinal products: a question of life or death?

Karin H Hoogendoorn, Daan J A Crommelin, Wim Jiskoot, 2020, Journal of pharmaceutical sciences.

Pharmaceutical sciences in 2020

Daan Crommelin, K. Midha, H. Leufkens, 2010, Nature Reviews Drug Discovery.

In vivo targeting of OV-TL 3 immunoliposomes to ascitic ovarian carcinoma cells (OVCAR-3) in athymic nude mice.

G. Storm, D. Crommelin, P. Steerenberg, 1992, Cancer research.

Plasmid Engineering for Controlled and Sustained Gene Expression for Nonviral Gene Therapy

W. Hennink, D. Crommelin, E. Mastrobattista, 2006, Pharmaceutical Research.

Vesicles for tumour-associated antigen presentation to induce protective immunity: preparation, characterization and enhancement of the immune response by immunomodulators

D. Crommelin, W. Otter, J. J. Bergers, 1994 .

Comparison of 24 different adjuvants for inactivated HIV-2 split whole virus as antigen in mice. Induction of titres of binding antibodies and toxicity of the formulations.

J. Löwer, D. Crommelin, G. Kersten, 1995, Vaccine.

Targeted delivery of diphtheria toxin via immunoliposomes: efficient antitumor activity in the presence of inactivating anti‐diphtheria toxin antibodies

J. Hendriks, G. Storm, D. Crommelin, 1996, FEBS letters.

Workshop on Bioanalytical Methods Validation for Macromolecules: Summary Report

Krys J. Miller, Michael Geier, Steve J. Swanson, 2001, Pharmaceutical Research.

Pharmacy preparations: Back in the limelight? Pharmacists make up your mind!

D. Crommelin, Y. Bouwman-Boer, 2016, International journal of pharmaceutics.

The effect of core composition in biodegradable oligomeric micelles as taxane formulations.

C. van Nostrum, W. Hennink, D. Crommelin, 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Liposomal Meningococcal B Vaccination: Role of Dendritic Cell Targeting in the Development of a Protective Immune Response

Wim E. Hennink, Wim Jiskoot, W. Hennink, 2003, Infection and Immunity.

Treatment with liposome-bound recombinant human tumor necrosis factor-alpha suppresses parasitemia and protects against Plasmodium berghei k173-induced experimental cerebral malaria in mice.

N. S. Postma, D. Crommelin, W. Eling, 1999, The Journal of pharmacology and experimental therapeutics.

The role of bile salts in the intestinal absorption of drugs

D. Crommelin, F. Poelma, J. Tukker, 1990 .

Antigen Carriers: A Success Determining Factor for Subunit Vaccines?

E. C. Beuvery, D. Crommelin, G. Kersten, 1990 .

Novel developments in liposomal delivery of peptides and proteins

D. Crommelin, G. Storm, D. Crommelin, 1995 .

Drug-laden liposomes in antitumor therapy and in the treatment of parasitic diseases.

G. Storm, D. Crommelin, W. H. Jong, 1990 .

Effects of additives on the physico-chemical properties of sprayed ethylcellulose films

D. Crommelin, E. V. Bommel, J. Fokkens, 1989 .

Semisolid, self-catalyzed poly(ortho ester)s as controlled-release systems: protein release and protein stability issues.

Wim E Hennink, Jorge Heller, W. Hennink, 2002, Journal of pharmaceutical sciences.

Effect of DNA topology on the transfection efficiency of poly((2-dimethylamino)ethyl methacrylate)-plasmid complexes.

W. Hennink, W. Jiskoot, D. Crommelin, 1999, Journal of controlled release : official journal of the Controlled Release Society.

Thiolated Recombinant Human Tumor Necrosis Factor-Alpha Protects against Plasmodium bergheiK173-Induced Experimental Cerebral Malaria in Mice

N. S. Postma, D. Crommelin, W. Eling, 1999, Antimicrobial Agents and Chemotherapy.

The Nuclear Pore Complex: The Gateway to Successful Nonviral Gene Delivery

W. Hennink, R. Oosting, G. Koning, 2006, Pharmaceutical Research.

Covalent attachment of an NLS-peptide to linear dna does not enhance transfection efficiency of cationic polymer based gene delivery systems.

W. Hennink, R. Oosting, G. Koning, 2005, Journal of Controlled Release.

Subcutaneous administration of HMG-CoA reductase inhibitors in hyperlipidaemic and normal rats

M. Griffioen, D. Crommelin, M. Krajnc-Franken, 1992, Laboratory animals.

Antibody-Drug Conjugates

R. A. Lipper, D. Crommelin, W. Shen, 2015, AAPS Advances in the Pharmaceutical Sciences Series.

Dissolution kinetics of griseofulvin in sodium dodecylsulphate solutions.

D. Crommelin, J. C. Offringa, J. D. de Smidt, 1987, Journal of pharmaceutical sciences.

Nonviral gene delivery systems: From simple transfection agents to artificial viruses.

D. Crommelin, M. van der Aa, E. Mastrobattista, 2005, Drug discovery today. Technologies.

Effect of immunomodulators on specific tumor immunity induced by liposome‐encapsulated tumor‐associated antigens

D. Crommelin, P. Steerenberg, W. den Otter, 1994, International journal of cancer.

Scientific considerations for complex drugs in light of established and emerging regulatory guidance

Chris Holloway, J. S. Wyatt, Beatriz Silva Lima, 2012, Annals of the New York Academy of Sciences.

Cancer nanomedicine: Is targeting our target?

Fabian Kiessling, Daan Crommelin, Gert Storm, 2016, Nature reviews. Materials.

The Science is There: Key Considerations for Stabilizing Viral Vector-Based Covid-19 Vaccines

W. Jiskoot, A. Lubiniecki, D. Volkin, 2020, Journal of Pharmaceutical Sciences.

Critical factors for liposome-incorporated tumour-associated antigens to induce protective tumour immunity to SL2 lymphoma cells in mice

D. Crommelin, P. Steerenberg, W. Otter, 1993, Cancer Immunology, Immunotherapy.

Fluorescence in situ hybridization to monitor the intracellular location and accessibility of plasmid DNA delivered by cationic polymer-based gene carriers.

W. Hennink, R. Oosting, G. Koning, 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality.

Steven Kozlowski, Theodore W Randolph, C Russell Middaugh, 2009, Journal of pharmaceutical sciences.

Thrombolytic Treatment with Tissue-type Plasminogen Activator (t-PA) Containing Liposomes in Rabbits: a Comparison with Free t-PA

D. Crommelin, C. Kluft, J. Emeis, 1995, Thrombosis and Haemostasis.

Subcutaneous Administration of Superoxide Dismutase Entrapped in Long Circulating Liposomes: In Vivo Fate and Therapeutic Activity in an Inflammation Model

W. Oyen, G. Storm, D. Crommelin, 2000, Pharmaceutical Research.

Immunoliposomes as Enzyme-Carriers (Immuno-Enzymosomes) for Antibody-Directed Enzyme Prodrug Therapy (ADEPT): Optimization of Prodrug Activating Capacity

G. Storm, D. Crommelin, M. Vingerhoeds, 1996, Pharmaceutical Research.

The Cryopreservation of Liposomes. 1. A Differential Scanning Calorimetry Study of the Thermal Behavior of a Liposome Dispersion Containing Mannitol During Freezing/Thawing

D. Crommelin, M. V. van Steenbergen, H. Talsma, 1991, Pharmaceutical Research.

Lipid-coated polyplexes for targeted gene delivery to ovarian carcinoma cells

Wim E Hennink, Gert Storm, Enrico Mastrobattista, 2001, Cancer Gene Therapy.

Gamma-irradiation of liposomes composed of saturated phospholipids: effect of bilayer composition, size, concentration and absorbed dose on chemical degradation and physical destabilization of liposomes.

D. Crommelin, N. Zuidam, C. Versluis, 1996, Biochimica et biophysica acta.

Differential scanning calorimetric analysis of dipalmitoylphosphatidylcholine-liposomes upon hydrolysis

D. Crommelin, N. Zuidam, 1995 .

Development of a procedure for coupling the homing device glu-plasminogen to liposomes.

D. Crommelin, C. Kluft, J. Heeremans, 1992, Biochimica et biophysica acta.

The effect of aging on the physical stability of liposome dispersions.

D. Crommelin, M. Grit, 1992, Chemistry and physics of lipids.

Kinetics and prophylactic efficacy of increasing dosages of liposome-encapsulated chloroquine after intramuscular injection into mice

D. Crommelin, J. Zuidema, F. Kadir, 1992 .

Influence of injection volume on the release kinetics of liposomal chloroquine administered subcutaneously or intramuscularly to mice

D. Crommelin, J. Zuidema, F. Kadir, 1991 .

A differential scanning calorimetry study of the thermal behavior of water-dipalmitoylphosphatidylcholine mixtures at subzero temperatures: effects of water content, surface charge, and cholesterol.

D. Crommelin, J. C. Offringa, R. Plekkenpol, 1987, Journal of Pharmacy and Science.

Liposomes for Local Sustained Drug Release

G. Storm, D. Crommelin, C. Oussoren, 2000 .

The influence of the route of administration and liposome composition on the potential of liposomes to protect tissue against local toxicity of two antitumor drugs.

G. Storm, D. Crommelin, W. Eling, 1998, Biochimica et biophysica acta.

Liposomes: vehicles for the targeted and controlled delivery of peptides and proteins

G. Storm, D. Crommelin, M. Vingerhoeds, 1997 .

Controlled Release of Liposomes from Biodegradable Dextran Microspheres: A Novel Delivery Concept

Wim E. Hennink, W. Hennink, D. Crommelin, 2000, Pharmaceutical Research.

Hydrolysis of Phospholipids in Liposomes and Stability- Indicating Analytical Techniques

D. Crommelin, N. Zuidam, 2016, Liposome Technology.

Differential scanning calorimetry

Y. Barenholz, D. Crommelin, N. Zuidam, 1998 .

Influence of freezing and freeze-drying on the stability of liposomes dispersed in aqueous media

A. A. Hincal, D. Crommelin, H. Talsma, 1988 .

Modeling the release of proteins from degrading crosslinked dextran microspheres using kinetic Monte Carlo simulations.

Wim E Hennink, Wim Jiskoot, Thijs J H Vlugt, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Purification and stabilisation of a poorly soluble mouse IgG3 monoclonal antibody.

E. C. Beuvery, W. Jiskoot, D. Crommelin, 1991, Journal of immunological methods.

How to select a nanosimilar

Beat Flühmann, Daan J.A. Crommelin, Alain Astier, 2017, Annals of the New York Academy of Sciences.

Stabilization of Peptide Vesicles by Introducing Inter-Peptide Disulfide Bonds

Wim E. Hennink, Enrico Mastrobattista, W. Hennink, 2009, Pharmaceutical Research.

A versatile method for the conjugation of proteins and peptides to poly[2-(dimethylamino)ethyl methacrylate].

W. Hennink, R. Liskamp, D. Crommelin, 1999, Bioconjugate chemistry.

A novel family of L-amino acid-based biodegradable polymer-lipid conjugates for the development of long-circulating liposomes with effective drug-targeting capacity.

W. Hennink, M. Wauben, G. Storm, 2003, Bioconjugate chemistry.

Beat Flühmann, Imre Klebovich, Stefan Mühlebach, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Epilogue: What Did We Learn? What Can We Expect in the Future? Concluding Remarks and Outstanding Issues

D. Crommelin, J. D. Vlieger, 2015 .

How to Regulate Nonbiological Complex Drugs (NBCD) and Their Follow-on Versions: Points to Consider

V. Shah, D. Crommelin, S. Stegemann, 2013, The AAPS Journal.

The therapeutic equivalence of complex drugs.

Gert Storm, Huub Schellekens, Stefan Mühlebach, 2011, Regulatory toxicology and pharmacology : RTP.

Different Pharmaceutical Products Need Similar Terminology

V. Shah, D. Crommelin, H. Schellekens, 2013, The AAPS Journal.

Structural Characterization and Immunogenicity in Wild-Type and Immune Tolerant Mice of Degraded Recombinant Human Interferon Alpha2b

Huub Schellekens, Wim Jiskoot, M. Slijper, 2005, Pharmaceutical Research.

Interference of ϵ-amino-caproic acid with [N-succinimidyl S-acetylthioacetate derived] thiol-introduction into glu-plasminogen

D. Crommelin, C. Kluft, J. Heeremans, 1994 .

Immunogenic activity of gonococcal PI in mice delivered in liposomes, iscoms and detergent complexes

E. C. Beuvery, W. Jiskoot, F. Dalen, 1988 .

Pharmaceutical biotechnology : fundamentals and applications

B. Meibohm, D. Crommelin, R. Sindelar, 2008 .

Introduction: Defining the Position of Non-Biological Complex Drugs

D. Crommelin, S. Mühlebach, J. D. Vlieger, 2015 .

The Preparation of Dextran Microspheres in an All-Aqueous System: Effect of the Formulation Parameters on Particle Characteristics

W. Hennink, D. Crommelin, R. Stenekes, 1998, Pharmaceutical Research.

Pharmaceutical Biotechnology: An Introduction for Pharmacists and Pharmaceutical Scientists

Daan J.A. Crommelin, Robert D. Sindelar, D. Crommelin, 1997 .

Identification of formaldehyde-induced modifications in proteins: reactions with insulin.

W. Hennink, W. Jiskoot, D. Crommelin, 2006, Bioconjugate chemistry.

Dissolution at porous interfaces VI: Multiple pore systems.

D. Crommelin, C. J. de Blaey, H. Grijseels, 1984, Journal of pharmaceutical sciences.

Multilamellar or multivesicular vesicles

Daan J.A. Crommelin, D. Crommelin, H. Talsma, 1987 .

Impact of the pharmaceutical sciences on health care: a reflection over the past 50 years.

Malcolm Rowland, Christian R Noe, C. Noe, 2012, Journal of pharmaceutical sciences.

Liposomal Delivery of Peptides and Proteins

G. Storm, D. Crommelin, M. Vingerhoeds, 1995 .

Targeting of peptide and protein drugs

G. Storm, D. Crommelin, 1994 .

Immunoliposomes in vivo.

G. Storm, D. Crommelin, M. Vingerhoeds, 1994, ImmunoMethods.

Liposomal Drug Delivery: Possibilities for Manipulation

G. Storm, D. Crommelin, M. Vingerhoeds, 1994 .

Biodistribution and Therapeutic Utility of Liposomal Drug Carrier Systems

G. Storm, D. Crommelin, M. Vingerhoeds, 1993 .

Antibody response to aggregated human interferon alpha2b in wild-type and transgenic immune tolerant mice depends on type and level of aggregation.

Huub Schellekens, Wim Jiskoot, C. Maas, 2006, Journal of pharmaceutical sciences.

Dissolution at porous interfaces II. A study of pore effects through rotating disc experiments

D. Crommelin, C. J. Blaey, L. Bloois, 1983 .

RP-hPLC/ESI MS determination of acyl chain positions in phospholipids

J. Brouwers, D. Crommelin, J. J. K. D. Bosch, 2002 .

The effect of formulation parameters on the size of poly-((2-dimethylamino)ethyl methacrylate)-plasmid complexes.

W. Hennink, D. Crommelin, R. Verrijk, 1999, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Hydrodynamic approach to dissolution rate

D. Crommelin, C. J. Blaey, H. Grijseels, 1981, Pharmaceutisch weekblad.

Formulation of Biologics Including Biopharmaceutical Considerations

Daan J.A. Crommelin, Wim Jiskoot, Andrea Hawe, 2019, Pharmaceutical Biotechnology.

Characterization and Protection in Mice of Outer Membrane Proteins from Pasteurella multocida A:1 Incorporated in Lipid Vaccine Delivery Systems

Gideon, W. Jiskoot, D. Crommelin, 2004 .

The regulator’s perspective: How should new therapies and follow-on products for MS be clinically evaluated in the future?

Jana Lízrová Preiningerová, K. Broich, D. Crommelin, 2016, Multiple sclerosis.

Non-biological complex drugs (NBCDs) and their follow-on versions: time for an editorial section

Gerrit Borchard, Vinod P. Shah, Jon S. B. de Vlieger, 2015 .

How to Regulate Nonbiological Complex Drugs (NBCD) and Their Follow-on Versions: Points to Consider

Vinod P. Shah, Rogério Gaspar, Huub Schellekens, 2013, The AAPS Journal.

Small oligomeric micelles based on end group modified mPEG : Oligocaprolactone with monodisperse hydrophobic blocks

W. Hennink, D. Crommelin, R. Verrijk, 2007 .

Rapid determination of acyl chain position in egg phosphatidylcholine by high performance liquid chromatography/electrospray mass spectrometry

D. Crommelin, J. J. K. D. Bosch, E. Vernooij, 1998 .

Dissolution rate behavior of hydroxyapatite-fluorapatite mixtures.

J. Fox, D. Crommelin, W. Higuchi, 1983, Caries research.

Liposomes as Carriers for Drugs and Antigens: Approaches to Preserve Their Long Term Stability

D. Crommelin, H. Talsma, N. Zuidam, 1994 .

Solubilization of lipophilic drugs by amphiphiles: improvement of the apparent solubility of almitrine bismesylate by liposomes, mixed micelles and O/W emulsions

D. Crommelin, L. Bloois, D. Dekker, 1987 .

Analytical Approaches to the Study of Monoclonal Antibody Stability

E. C. Beuvery, W. Jiskoot, D. Crommelin, 1990, Pharmaceutical Research.

Bactericidal antibody recognition of a PorA epitope of Neisseria meningitidis: Crystal structure of a Fab fragment in complex with a fluorescein‐conjugated peptide

P. Gros, T. Logtenberg, D. Crommelin, 1997, Proteins.

Endosomal Escape of Polymeric Gene Delivery Complexes Is Not Always Enhanced by Polymers Buffering at Low pH

W. Hennink, G. Koning, D. Crommelin, 2004 .

Hydrophilic Polyester Microspheres: Effect of Molecular Weight and Copolymer Composition on Release of BSA

C. van Nostrum, W. Hennink, D. Crommelin, 2010, Pharmaceutical Research.

Preparation and characterization of protein loaded microspheres based on a hydroxylated aliphatic polyester, poly(lactic-co-hydroxymethyl glycolic acid).

C. van Nostrum, W. Hennink, W. Jiskoot, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Targeting influenza virosomes to ovarian carcinoma cells

D. Crommelin, G. Storm, D. Crommelin, 2001, FEBS letters.

Harmonization of regulatory approaches for evaluating therapeutic equivalence and interchangeability of multisource drug products: workshop summary report.

Lawrence X. Yu, V. Shah, J. Dressman, 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

LIPOSOMES AS DRUG DELIVERY SYSTEMS. III: STABILIZATION

D. Crommelin, H. Talsma, 1993 .

Comparison of four experimental techniques for studying drug absorption kinetics in the anesthetized rat in situ.

D. Crommelin, J. Tukker, J. Bijdendijk, 1986, Journal of pharmaceutical sciences.

Chemical hydrolysis of DOTAP and DOPE in a liposomal environment.

D. Crommelin, J. J. Kettenes-van den Bosch, W. Underberg, 2002, Journal of controlled release : official journal of the Controlled Release Society.

Clot Accumulation Characteristics of Plasminogen-bearing Liposomes in a Flow-system

D. Crommelin, C. Kluft, H. Feitsma, 1998, Thrombosis and Haemostasis.

Optimization and quantification of protein synthesis inside liposomes

Wim E Hennink, Markus de Raad, Enrico Mastrobattista, 2010, Journal of liposome research.

Report of the AAPS Guidance Forum on the FDA Draft Guidance for Industry: “Drug Products, Including Biological Products, that Contain Nanomaterials”

Rachael M. Crist, V. Shah, D. Crommelin, 2019, The AAPS Journal.

1H NMR Quantification of poly(Ethylene Glycol)-Phosphatidylethanolamine in Phospholipid Mixtures

D. Crommelin, J. Herron, C. Gentry, 1999, Pharmaceutical Research.

Viscosity measurement in aqueous polymer solutions by dynamic light scattering

D. Crommelin, J. Smidt, 1991 .

Dissolution kinetics of theophylline in aqueous polymer solutions

D. Crommelin, J. C. Offringa, J. Smidt, 1991 .

Stable sugar-based protein formulations by supercritical fluid drying.

Geert-Jan Witkamp, Wim Jiskoot, W. Jiskoot, 2008, International journal of pharmaceutics.

Stealth™ Therapeutic Systems: Rationale and Strategies

G. Storm, D. Crommelin, 1998 .

Reaction to the paper: Interaction of Polysorbate 80 with Erythropoietin: A Case Study in Protein–Surfactant Interactions

Huub Schellekens, Wim Jiskoot, W. Jiskoot, 2006, Pharmaceutical Research.

Hydrogels for the Controlled Release of Pharmaceutical Proteins

W. Hennink, D. Crommelin, R. Verrijk, 2001 .

Harmonization of Regulatory Approaches for Evaluating Therapeutic Equivalence and Interchangeability of Multisource Drug Products: Workshop Summary Report

Lawrence X. Yu, J. Dressman, T. Hyslop, 2011, The AAPS Journal.

Differential scanning calorimetry

Y. Barenholz, D. Crommelin, N. Zuidam, 1998 .

Stability of Liposomes on Storage

D. Crommelin, P. Salemink, G. J. Fransen, 1986 .

Liposomes: From the Bench to the Bed

G. Storm, D. Crommelin, 2003, Journal of liposome research.

In vitro degradation behavior of microspheres based on cross-linked dextran.

Zhibing Zhang, W. Hennink, W. Jiskoot, 2006, Biomacromolecules.

Editorial: Public-Private Partnerships as Drivers of Innovation in Healthcare

D. Crommelin, R. D. de Vrueh, J. S. D. de Vlieger, 2019, Front. Med..

Microspheres of hydrophilic PLGA highly attractive for protein delivery.

C. van Nostrum, W. Hennink, W. Jiskoot, 2010, Journal of controlled release : official journal of the Controlled Release Society.

A purification strategy for the production of clinical grade monoclonal antibodies.

W. Jiskoot, D. Crommelin, J. Gebbinck, 1990, Developments in biological standardization.

Pharmaceutical Biotechnology

B. Meibohm, D. Crommelin, R. Sindelar, 2013, Springer New York.

Peptide nanocarriers for intracellular delivery of photosensitizers.

Wim E Hennink, Enrico Mastrobattista, W. Hennink, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Towards more effective advanced drug delivery systems.

D. Crommelin, A. Florence, 2013, International journal of pharmaceutics.

Identification of Formaldehyde-induced Modifications in Proteins

W. Hennink, W. Jiskoot, D. Crommelin, 2004, Journal of Biological Chemistry.

Lymphatic uptake and biodistribution of liposomes after subcutaneous injection. II. Influence of liposomal size, lipid compostion and lipid dose.

D. Crommelin, G. Storm, D. Crommelin, 1997, Biochimica et biophysica acta.

Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality.

Patrick G. Swann, W. Jiskoot, G. Winter, 2009, Journal of pharmaceutical sciences.

Adhesion molecules: a new target for immunoliposome‐mediated drug delivery

D. Crommelin, D. Crommelin, P. Henricks, 1995, FEBS letters.

Antigen-expressing immunostimulatory liposomes as a genetically programmable synthetic vaccine

W. Hennink, D. Crommelin, M. de Raad, 2010, Systems and Synthetic Biology.

Effect of the spraying conditions and nozzle design on the shape and size distribution of particles obtained with supercritical fluid drying.

W. Jiskoot, D. Crommelin, G. Hofland, 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Stability of Protein Pharmaceuticals: Recent Advances.

Robert W. Payne, D. Katayama, D. Crommelin, 2024, Pharmaceutical research.