I. Sola

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Targeted Recombination Demonstrates that the Spike Gene of Transmissible Gastroenteritis Coronavirus Is a Determinant of Its Enteric Tropism and Virulence

C. Sánchez, A. Izeta, J. Sánchez-Morgado, 1999, Journal of Virology.

Alphacoronavirus Protein 7 Modulates Host Innate Immune Response

Juan Carlos Oliveros, J. Oliveros, I. Sola, 2013, Journal of Virology.

Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis

S. Perlman, I. Sola, L. Enjuanes, 2018, mBio.

Host cell proteins interacting with the 3′ end of TGEV coronavirus genome influence virus replication

I. Sola, L. Enjuanes, F. Almazán, 2009, Virology.

MOV10 Helicase Interacts with Coronavirus Nucleocapsid Protein and Has Antiviral Activity

I. Sola, L. Enjuanes, S. Zúñiga, 2021, mBio.

Continuous and Discontinuous RNA Synthesis in Coronaviruses.

I. Sola, L. Enjuanes, F. Almazán, 2015, Annual review of virology.

Biochemical aspects of coronavirus replication and virus-host interaction.

I. Sola, L. Enjuanes, F. Almazán, 2006, Annual review of microbiology.

RNA-RNA and RNA-protein interactions in coronavirus replication and transcription

I. Sola, L. Enjuanes, F. Almazán, 2011, RNA biology.

Severe acute respiratory syndrome-related coronavirus: The species and its viruses – a statement of the Coronavirus Study Group

Christian Drosten, Ralph S. Baric, A. M. Leontovich, 2020, bioRxiv.

Canonical and Noncanonical Autophagy as Potential Targets for COVID-19

Daniel J Klionsky, D. Klionsky, I. Sola, 2020, Cells.

Molecular Basis of Coronavirus Virulence and Vaccine Development

I. Sola, L. Enjuanes, S. Zúñiga, 2016, Advances in Virus Research.

Reprint of: Coronavirus reverse genetic systems: Infectious clones and replicons☆

I. Sola, L. Enjuanes, F. Almazán, 2014, Virus Research.

Coronavirus derived expression systems. Progress and problems.

J. M. González, C. Sánchez, A. Izeta, 2001, Advances in experimental medicine and biology.

Expression of transcriptional units using transmissible gastroenteritis coronavirus derived minigenomes and full-length cDNA clones.

C. Sánchez, J. Sánchez-Morgado, S. Alonso, 2001, Advances in experimental medicine and biology.

Transmissible gastroenteritis coronavirus gene 7 is not essential but influences in vivo virus replication and virulence

I. Sola, M. Balasch, L. Enjuanes, 2003, Virology.

Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses

I. Sola, L. Enjuanes, M. Kikkert, 2016, PLoS pathogens.

Development of a Single-Cycle Infectious SARS-CoV-2 Virus Replicon Particle System for Use in Biosafety Level 2 Laboratories

S. Perlman, B. Manicassamy, I. Sola, 2021, Journal of virology.

Minimum Determinants of Transmissible Gastroenteritis Virus Enteric Tropism Are Located in the N-Terminus of Spike Protein

C. Sánchez, I. Sola, L. Enjuanes, 2019, Pathogens.

Virulence factors in porcine coronaviruses and vaccine design

C. Sánchez, I. Sola, L. Enjuanes, 2016, Virus Research.

FACTORS IN PORCINE CORONAVIRUSES AND VACCINE DESIGN

C. Sánchez, I. Sola, S. Zúñiga, 2016 .

Mutagenesis of Coronavirus nsp14 Reveals Its Potential Role in Modulation of the Innate Immune Response

I. Sola, L. Enjuanes, M. Bécares, 2016, Journal of Virology.

Antigenic structures stably expressed by recombinant TGEV-derived vectors

C. Sánchez, I. Sola, L. Enjuanes, 2014, Virology.

Transmissible Gastroenteritis Coronavirus Genome Packaging Signal Is Located at the 5′ End of the Genome and Promotes Viral RNA Incorporation into Virions in a Replication-Independent Process

I. Sola, L. Enjuanes, Pedro A. Mateos-Gómez, 2013, Journal of Virology.

Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine Candidate

I. Sola, L. Enjuanes, F. Almazán, 2013, mBio.

Vectored vaccines to protect against PRRSV

I. Sola, L. Enjuanes, Jazmina L G Cruz, 2010, Virus Research.

Construction of a Severe Acute Respiratory Syndrome Coronavirus Infectious cDNA Clone and a Replicon To Study Coronavirus RNA Synthesis

S. Alonso, I. Sola, L. Enjuanes, 2006, Journal of Virology.

Engineering the Transmissible Gastroenteritis Virus Genome as an Expression Vector Inducing Lactogenic Immunity

S. Alonso, I. Sola, M. Balasch, 2003, Journal of Virology.

Coronavirus derived expression systems

J. M. González, C. Sánchez, A. Izeta, 2001, Journal of Biotechnology.

Contribution of Host miRNA-223-3p to SARS-CoV-Induced Lung Inflammatory Pathology

J. Oliveros, I. Sola, L. Enjuanes, 2022, mBio.

An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern

F. Grosveld, B. Bosch, W. Baumgärtner, 2022, Science immunology.

Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection

J. Segalés, B. Bosch, M. Koopmans, 2018, Science Advances.

The deubiquitinating activity of Middle East respiratory syndrome coronavirus papain-like protease delays the innate immune response and enhances virulence in a mouse model

I. Sola, L. Enjuanes, M. Kikkert, 2019, bioRxiv.

Nature of viruses and pandemics: Coronaviruses

C. Sánchez, I. Sola, L. Enjuanes, 2022, Current Research in Immunology.

Engineering passive immunity in transgenic mice secreting virus-neutralizing antibodies in milk

J. Castilla, B. Pintado, J. Sánchez-Morgado, 1998, Nature Biotechnology.

Development of Protection against Coronavirus Induced Diseases

J. Castilla, B. Pintado, I. Sola, 1995 .

Transgenic Mice Secreting Coronavirus Neutralizing Antibodies into the Milk

B. Pintado, A. Clark, C. Whitelaw, 1998, Journal of Virology.

MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection

S. Perlman, Anthony R. Fehr, A. García-Sastre, 2018, PLoS pathogens.

Gene expression, virulence and vaccine development in coronaviruses

I. Sola, L. Enjuanes, F. Almazán, 2008, Journal of Biotechnology.

Regulation of Coronavirus Transcription: Viral and Cellular Proteins Interacting with Transcription-Regulating Sequences

S. Alonso, I. Sola, L. Enjuanes, 2006, Advances in experimental medicine and biology.

MERS-CoV ORF4b is a virulence factor involved in the inflammatory pathology induced in the lungs of mice

I. Sola, L. Enjuanes, R. Fernández-Delgado, 2022, PLoS pathogens.

Role of transcription regulatory sequence in regulation of gene expression and replication of porcine reproductive and respiratory syndrome virus

I. Sola, L. Enjuanes, Chengbao Wang, 2017, Veterinary Research.

Biochemical Aspects of Coronavirus Replication

I. Sola, L. Enjuanes, F. Almazán, 2006, Advances in experimental medicine and biology.

Interference of coronavirus infection by expression of IgG or IgA virus neutralizing antibodies.

J. Castilla, I. Sola, L. Enjuanes, 1998, Advances in experimental medicine and biology.

Interference of coronavirus infection by expression of immunoglobulin G (IgG) or IgA virus-neutralizing antibodies

J. Castilla, I. Sola, L. Enjuanes, 1997, Journal of virology.

Recombinant dimeric small immunoproteins neutralize transmissible gastroenteritis virus infectivity efficiently in vitro and confer passive immunity in vivo.

I. Sola, J. Plana-duran, L. Enjuanes, 2007, The Journal of general virology.

Lactogenic immunity in transgenic mice producing recombinant antibodies neutralizing coronavirus.

J. Castilla, B. Pintado, J. Sánchez-Morgado, 1998, Advances in experimental medicine and biology.

Development of protection against coronavirus induced diseases. A review.

J. Castilla, B. Pintado, I. Sola, 1995, Advances in experimental medicine and biology.

Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19

Kristen Fortney, K. Wilhelmsen, S. Perlman, 2022, Nature.

Use of virus vectors for the expression in plants of active full‐length and single chain anti‐coronavirus antibodies

I. Sola, L. Enjuanes, G. Lomonossoff, 2006, Biotechnology journal.

An antibody derivative expressed from viral vectors passively immunizes pigs against transmissible gastroenteritis virus infection when supplied orally in crude plant extracts

I. Sola, L. Enjuanes, G. Lomonossoff, 2006, Plant biotechnology journal.

Development of a SARS- CoV-2 vaccine based in non- infective replicons

Principal Investigators, I. Sola, L. Enjuanes, 2021 .

Cytoplasmic ribonucleoprotein complexes, RNA helicases and coronavirus infection

I. Sola, L. Enjuanes, S. Zúñiga, 2022, Frontiers in Virology.

Atypical Mutational Spectrum of SARS-CoV-2 Replicating in the Presence of Ribavirin

E. Domingo, I. Sola, L. Enjuanes, 2023, Antimicrobial agents and chemotherapy.

Middle East Respiratory Syndrome Coronavirus Gene 5 Modulates Pathogenesis in Mice

S. Perlman, I. Sola, L. Enjuanes, 2020, Journal of Virology.

Coronavirus reverse genetic systems: Infectious clones and replicons

I. Sola, L. Enjuanes, F. Almazán, 2014, Virus Research.

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

A. M. Leontovich, L. Poon, R. Baric, 2020, Nature Microbiology.

Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19

N. Krogan, R. Paredes, B. Clotet, 2022, Life Science Alliance.

Atypical Mutational Spectrum of SARS-CoV-2 Replicating in the Presence of Ribavirin

E. Domingo, I. Sola, L. Enjuanes, 2023, Antimicrobial agents and chemotherapy.

Recombinant Chimeric Transmissible Gastroenteritis Virus (TGEV)—Porcine Epidemic Diarrhea Virus (PEDV) Virus Provides Protection against Virulent PEDV

C. Sánchez, I. Sola, L. Enjuanes, 2019, Viruses.

Coronavirus nucleocapsid protein is an RNA chaperone

I. Sola, J. Plana-duran, L. Enjuanes, 2006, Virology.

Coronavirus Gene 7 Counteracts Host Defenses and Modulates Virus Virulence

I. Sola, L. Enjuanes, Jazmina L G Cruz, 2011, PLoS pathogens.

SARS-CoV-Encoded Small RNAs Contribute to Infection-Associated Lung Pathology

J. Oliveros, I. Sola, L. Enjuanes, 2017, Cell Host & Microbe.

An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern

F. Grosveld, B. Bosch, W. Baumgärtner, 2022, bioRxiv.

Effects of Infection with Transmissible Gastroenteritis Virus on Concomitant Immune Responses to Dietary and Injected Antigens

I. Sola, L. Enjuanes, C. Stokes, 2004, Clinical Diagnostic Laboratory Immunology.

Adaptive Evolution of MERS-CoV to Species Variation in DPP4

I. Sola, L. Enjuanes, Stephanie N. Seifert, 2018, Cell Reports.

Coronavirus Reverse Genetics and Development of Vectors for Gene Expression

S. Alonso, I. Sola, L. Enjuanes, 2005, Current topics in microbiology and immunology.

Specific Secretion of Active Single-Chain Fv Antibodies into the Supernatants of Escherichia coliCultures by Use of the Hemolysin System

V. de Lorenzo, I. Sola, L. Enjuanes, 2000, Applied and Environmental Microbiology.

RNA-Affinity Chromatography

I. Sola, L. Enjuanes, Pedro A. Mateos-Gómez, 2013 .

SARS-CoV-2-Mediated Lung Edema and Replication Are Diminished by Cystic Fibrosis Transmembrane Conductance Regulator Modulators

S. Perlman, J. Oliveros, I. Sola, 2023, mBio.

Role of RNA chaperones in virus replication

I. Sola, L. Enjuanes, Jazmina L G Cruz, 2008, Virus Research.

A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies

F. Grosveld, B. Bosch, I. Sola, 2021, Nature Communications.

Isolation of cross-reactive monoclonal antibodies against divergent human coronaviruses that delineate a conserved and vulnerable site on the spike protein

F. Grosveld, B. Bosch, I. Sola, 2020, bioRxiv.

The Polypyrimidine Tract-Binding Protein Affects Coronavirus RNA Accumulation Levels and Relocalizes Viral RNAs to Novel Cytoplasmic Domains Different from Replication-Transcription Sites

I. Sola, L. Enjuanes, F. Almazán, 2011, Journal of Virology.

Interference with virus and bacteria replication by the tissue specific expression of antibodies and interfering molecules.

J. M. González, C. Sánchez, A. Izeta, 1999, Advances in experimental medicine and biology.

CORONAVIRUS RNA ACCUMULATION LEVELS AND RELOCALIZES 2 VIRAL RNAs TO NOVEL CYTOPLASMIC DOMAINS DIFFERENT FROM 3

I. Sola, L. Enjuanes, F. Almazán, 2011 .

In vitro and in vivo expression of foreign genes by transmissible gastroenteritis coronavirus-derived minigenomes.

J. Teifke, A. Izeta, S. Alonso, 2002, Journal of General Virology.

New strategies in the development of PRRS vaccines. Subunit vaccines and self-limiting vectors, based on defective coronaviruses

E. Viaplana, A. Izeta, S. Alonso, 2000 .

Identification of a Coronavirus Transcription Enhancer

I. Sola, L. Enjuanes, S. Zúñiga, 2008, Journal of Virology.

Complete Genome Sequence of Transmissible Gastroenteritis Coronavirus PUR46-MAD Clone and Evolution of the Purdue Virus Cluster

C. Sánchez, A. Izeta, I. Sola, 2004, Virus Genes.

Role of Nucleotides Immediately Flanking the Transcription-Regulating Sequence Core in Coronavirus Subgenomic mRNA Synthesis

S. Alonso, I. Sola, L. Enjuanes, 2005, Journal of Virology.

Long-Distance RNA-RNA Interactions in the Coronavirus Genome Form High-Order Structures Promoting Discontinuous RNA Synthesis during Transcription

I. Sola, L. Enjuanes, S. Zúñiga, 2012, Journal of Virology.

Cross-neutralization activity against SARS-CoV-2 is present in currently available intravenous immunoglobulins

J. Segalés, I. Sola, L. Enjuanes, 2020, bioRxiv.

Suitability of transiently expressed antibodies for clinical studies: product quality consistency at different production scales

B. Bosch, I. Sola, L. Enjuanes, 2022, mAbs.

Coronavirus Nucleocapsid Protein Facilitates Template Switching and Is Required for Efficient Transcription

I. Sola, L. Enjuanes, Jazmina L G Cruz, 2009, Journal of Virology.

Contribution to pathogenesis of accessory proteins of deadly human coronaviruses

I. Sola, L. Enjuanes, Ricardo Requena-Platek, 2023, Frontiers in Cellular and Infection Microbiology.

Genetically Engineered Live-Attenuated Middle East Respiratory Syndrome Coronavirus Viruses Confer Full Protection against Lethal Infection

I. Sola, L. Enjuanes, S. Zúñiga, 2021, mBio.

Sequence Motifs Involved in the Regulation of Discontinuous Coronavirus Subgenomic RNA Synthesis

S. Alonso, I. Sola, L. Enjuanes, 2004, Journal of Virology.

Middle East respiratory syndrome coronavirus vaccine based on a propagation-defective RNA replicon elicited sterilizing immunity in mice

I. Sola, L. Enjuanes, S. Zúñiga, 2021, Proceedings of the National Academy of Sciences.

Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization.

N. Krogan, R. Paredes, B. Clotet, 2021, medRxiv.

Engineering potent live attenuated coronavirus vaccines by targeted inactivation of the immune evasive viral deubiquitinase

I. Sidorov, I. Sola, L. Enjuanes, 2023, Nature Communications.

Viral PDZ Binding Motifs Influence Cell Behavior Through the Interaction with Cellular Proteins Containing PDZ Domains.

I. Sola, L. Enjuanes, C. Castaño-Rodríguez, 2021, Methods in molecular biology.

Transcription Regulatory Sequences and mRNA Expression Levels in the Coronavirus Transmissible Gastroenteritis Virus

A. Izeta, S. Alonso, I. Sola, 2002, Journal of Virology.

Structure and Functional Relevance of a Transcription-Regulating Sequence Involved in Coronavirus Discontinuous RNA Synthesis

David Dufour, I. Sola, L. Enjuanes, 2011, Journal of Virology.

Severe acute respiratory syndrome-related coronavirus : The species and its viruses – a statement of the Coronavirus Study Group