J. Breslow

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Physical exercise conditioning in the absence of weight loss reduces fasting and postprandial triglyceride-rich lipoprotein levels.

M. Weintraub, Y. Rosen, R. Otto, 1989, Circulation.

Whole population, genome-wide mapping of hidden relatedness.

Alexander Gusev, Itsik Pe'er, David Altshuler, 2009, Genome research.

Decreased cholesteryl ester transfer protein (CETP) mRNA and protein and increased high density lipoprotein following lipopolysaccharide administration in human CETP transgenic mice.

A. Tall, J. Breslow, A. Walsh, 1995, The Journal of clinical investigation.

Intracellular Cholesterol Transport

J. Breslow, R. Soccio, Jan L. Breslow, 2004, Arteriosclerosis, thrombosis, and vascular biology.

J. Breslow, R. Soccio, 2003, Journal of Biological Chemistry.

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

E. Rubin, Jonathan D. Smith, J. Breslow, 1992, Cell.

Screening Predictors of Weight Loss: An Integromics Approach

Yupu Liang, J. Breslow, P. Holt, 2020, bioRxiv.

Decreased HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior in apolipoprotein A-IV knockout mice.

J. Breslow, M. Merkel, T. Hayek, 1997, Journal of lipid research.

apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in heterozygotes.

J. Breslow, E. Voyiaziakis, T. Hayek, 1995, The Journal of clinical investigation.

Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction.

J. Buring, C. Hennekens, C. O’Donnell, 1997, Circulation.

Hyperglycemia and plasma lipid levels: a prospective study of young insulin-dependent diabetic patients.

J. Breslow, J. Sosenko, K. Gabbay, 1980, The New England journal of medicine.

Low-density lipoprotein subclass patterns and risk of myocardial infarction.

W C Willett, W. Willett, R. Krauss, 1988, JAMA.

Differential Gene Regulation of StarD4 and StarD5 Cholesterol Transfer Proteins

Rachel M. Adams, J. Breslow, R. Soccio, 2005, Journal of Biological Chemistry.

Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes.

R. Zechner, H. Radner, J. Breslow, 1995, The Journal of clinical investigation.

Tissue-specific methylation patterns and expression of the human apolipoprotein AI gene.

A. Razin, S. Eisenberg, J. Breslow, 1990, Journal of Biological Chemistry.

Methylation patterns of the human apoA-I/C-III/A-IV gene cluster in adult and embryonic tissues suggest dynamic changes in methylation during development.

A. Razin, S. Eisenberg, J. Breslow, 1991, The Journal of biological chemistry.

Methylation changes in the apolipoprotein AI gene during embryonic development of the mouse.

A. Razin, S. Eisenberg, J. Breslow, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Metabolic and genetic determinants of HDL metabolism and hepatic lipase activity in normolipidemic females.

E. Kass, S. Juo, J. Breslow, 1999, Journal of lipid research.

ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum.

V. Ord, D. Steinberg, J. Breslow, 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

Recombinant human cachectin/tumor necrosis factor but not interleukin-1 alpha downregulates lipoprotein lipase gene expression at the transcriptional level in mouse 3T3-L1 adipocytes

A. Cerami, J. Breslow, B. Sherry, 1988, Molecular and cellular biology.

Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase.

J. Friedman, R. Zechner, H. Radner, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: direct evidence that lipoprotein lipase bridging occurs in vivo.

H. Radner, J. Breslow, Y. Kako, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Inactive Lipoprotein Lipase (LPL) Alone Increases Selective Cholesterol Ester Uptake in Vivo, Whereas in the Presence of Active LPL It Also Increases Triglyceride Hydrolysis and Whole Particle Lipoprotein Uptake*

R. Zechner, H. Radner, J. Breslow, 2002, The Journal of Biological Chemistry.

Defective Phagocytosis of Apoptotic Cells by Macrophages in Atherosclerotic Lesions of ob/ob Mice and Reversal by a Fish Oil Diet

Brian C. Pridgen, A. Tall, J. Breslow, 2009, Circulation research.

Decreased early atherosclerotic lesions in hypertriglyceridemic mice expressing cholesteryl ester transfer protein transgene.

E. Rubin, A. Tall, J. Breslow, 1995, The Journal of clinical investigation.

Increased atherosclerosis in ApoE and LDL receptor gene knock-out mice as a result of human cholesteryl ester transfer protein transgene expression.

A. Tall, J. Breslow, L. Masucci-Magoulas, 1999, Arteriosclerosis, thrombosis, and vascular biology.

Laser capture microdissection analysis of gene expression in macrophages from atherosclerotic lesions of apolipoprotein E-deficient mice

E. Fisher, J. Breslow, R. Choudhury, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Algal docosahexaenoic acid affects plasma lipoprotein particle size distribution in overweight and obese adults.

K. Wittkowski, J. Breslow, L. Neff, 2011, The Journal of nutrition.

Algal DHA Affects Plasma Lipoprotein Particle Size Distribution in Overweight

K. Wittkowski, J. Breslow, L. Neff, 2010 .

Expression of the human apolipoprotein E gene is regulated by multiple positive and negative elements.

J. Breslow, T. Leff, J. D. Smith, 1988, The Journal of biological chemistry.

Apo A-I inhibits foam cell formation in Apo E-deficient mice after monocyte adherence to endothelium.

J. Breslow, J. Frank, J. D. Smith, 1999, The Journal of clinical investigation.

Human Cholesteryl Ester Transfer Protein Gene Proximal Promoter Contains Dietary Cholesterol Positive Responsive Elements and Mediates Expression in Small Intestine and Periphery While Predominant Liver and Spleen Expression Is Controlled by 5′-distal Sequences

A. Tall, J. Breslow, A. Walsh, 1996, The Journal of Biological Chemistry.

Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification.

J. Breslow, V. I. Zannis, 1981, Biochemistry.

Increased ADAM17 mRNA Expression and Activity Is Associated With Atherosclerosis Resistance in LDL-Receptor Deficient Mice

L. Holdt, D. Teupser, J. Breslow, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Loci on chromosomes 14 and 2, distinct from ABCG5/ABCG8, regulate plasma plant sterol levels in a C57BL/6J × CASA/Rk intercross

J. Breslow, E. M. Duncan, K. von Bergmann, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Recombinant human cachectin/tumor necrosis factor but not interleukin-1 alpha downregulates lipoprotein lipase gene expression at the transcriptional level in mouse 3T3-L1 adipocytes

A. Cerami, J. Breslow, B. Sherry, 1988 .

Dietary and drug treatment of primary hyperlipoproteinemia.

R. Krauss, N. Stone, D. Bilheimer, 1972, Annals of internal medicine.

Increased apo A-I and apo A-II fractional catabolic rate in patients with low high density lipoprotein-cholesterol levels with or without hypertriglyceridemia.

S. Eisenberg, J. Breslow, E. Brinton, 1991, The Journal of clinical investigation.

Hyperglycemic Ins2AkitaLdlr−/− mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease[S]

Brian C. Pridgen, J. Breslow, Jinxian Xu, 2011, Journal of Lipid Research.

An interaction between the human cholesteryl ester transfer protein (CETP) and apolipoprotein A-I genes in transgenic mice results in a profound CETP-mediated depression of high density lipoprotein cholesterol levels.

A. Tall, J. Breslow, A. Walsh, 1992, The Journal of clinical investigation.

Hypertriglyceridemia and cholesteryl ester transfer protein interact to dramatically alter high density lipoprotein levels, particle sizes, and metabolism. Studies in transgenic mice.

A. Tall, J. Breslow, A. Walsh, 1993, The Journal of clinical investigation.

Overexpression of apolipoprotein CII causes hypertriglyceridemia in transgenic mice.

J. Breslow, T. Leff, D. Rosenberg, 1994, The Journal of clinical investigation.

Combined hyperlipidemia in transgenic mice overexpressing human apolipoprotein Cl.

J. Breslow, H. Ginsberg, R. Ramakrishnan, 1996, The Journal of clinical investigation.

A Mouse Model with Features of Familial Combined Hyperlipidemia

A. Tall, J. Breslow, I. Goldberg, 1997, Science.

Localization of a liver-specific enhancer in the apolipoprotein E/C-I/C-II gene locus.

Y. Zhu, J. Breslow, A. Walsh, 1993, Journal of lipid research.

Epidemiology and Prevention Vitamin D May Not Improve Lipid Levels

J. Breslow, H. Kaufman, Mouneer A. Odeh, 2012 .

Vitamin D May Not Improve Lipid Levels: A Serial Clinical Laboratory Data Study

J. Breslow, H. Kaufman, Mouneer A. Odeh, 2012, Circulation.

Genetic determinants of myocardial infarction.

J. Breslow, M. Dammerman, Jan L. Breslow, 1995, Advances in experimental medicine and biology.

Genetic mutations affecting human lipoprotein metabolism.

J. Breslow, V. Zannis, V. I. Zannis, 1985, Advances in human genetics.

An inherited polymorphism in the human apolipoprotein A-I gene locus related to the development of atherosclerosis

R. Norum, J. Breslow, S. Karathanasis, 1983, Nature.

Human ApoA-I 1 Inhibits the Hydrolysis of HDL Triglyceride and the Decrease of HDL Size Induced by Hypertriglyceridemia and Cholesteryl Ester Transfer Protein in Transgenic Mice

E. Rubin, A. Tall, J. Breslow, 2013 .

Remodel Lesions Without Suppressing Indices of Inflammation or Oxidation High-Density Lipoproteins Retard the Progression of Atherosclerosis and Favorably

E. Fisher, J. Fallon, J. Breslow, 2004 .

ApoA-II maintains HDL levels in part by inhibition of hepatic lipase. Studies In apoA-II and hepatic lipase double knockout mice.

A. Tall, J. Breslow, X. Jiang, 1999, Journal of lipid research.

Human ApoA-II inhibits the hydrolysis of HDL triglyceride and the decrease of HDL size induced by hypertriglyceridemia and cholesteryl ester transfer protein in transgenic mice.

E. Rubin, A. Tall, J. Breslow, 1994, Journal of Clinical Investigation.

The full induction of human apoprotein A-I gene expression by the experimental nephrotic syndrome in transgenic mice depends on cis-acting elements in the proximal 256 base-pair promoter region and the trans-acting factor early growth response factor 1.

J. Milbrandt, E. Fisher, M. Madaio, 1998, The Journal of clinical investigation.

Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility.

J. Breslow, W. Weng, Wei Weng, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Intestinal expression of the human apoA-I gene in transgenic mice is controlled by a DNA region 3' to the gene in the promoter of the adjacent convergently transcribed apoC-III gene.

J. Breslow, A. Walsh, K. Wang, 1993, Journal of lipid research.

An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3' untranslated region polymorphisms.

J. Breslow, J. Halaas, M. Dammerman, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Effect of egg cholesterol and dietary fats on plasma lipids, lipoproteins, and apoproteins of normal women consuming natural diets.

C. Blum, J. Breslow, P. Herbert, 1987, Journal of lipid research.

Mapping of the human APOB gene to chromosome 2p and demonstration of a two-allele restriction fragment length polymorphism.

D. Miller, G. Bruns, J. Breslow, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Glycosylated hemoglobins and long-term blood glucose control in diabetes mellitus.

P. Gallop, J. Breslow, R. C. Ellison, 1977, The Journal of clinical endocrinology and metabolism.

Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse.

J. Breslow, A. Plump, C. Scott, 1994, Proceedings of the National Academy of Sciences of the United States of America.

High levels of human apolipoprotein A-I in transgenic mice result in increased plasma levels of small high density lipoprotein (HDL) particles comparable to human HDL3.

J. Breslow, A. Walsh, Y. Ito, 1989, The Journal of biological chemistry.

Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil.

M. Weintraub, S. Eisenberg, J. Breslow, 1987, The Journal of clinical investigation.

A DNA insertion in the apolipoprotein A-I gene of patients with premature atherosclerosis

J. Breslow, S. Karathanasis, V. Zannis, 1983, Nature.

Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene.

G. Bruns, J. Breslow, S. Karathanasis, 1985, The Journal of biological chemistry.

Primary hyperlipoproteinemia in infants.

J. Breslow, D. Fredrickson, 1973, Annual review of medicine.

Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice

J. Breslow, M. Merkel, L. Hudgins, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Vitamin D-binding protein levels do not influence the effect of vitamin D repletion on serum PTH and calcium: data from a randomized, controlled trial.

J. Breslow, M. Ponda, D. McGee, 2014, The Journal of clinical endocrinology and metabolism.

Decreased HDL 2 and HDL 3 Cholesterol , Apo A-I and Apo AII , and Increased Risk of Myocardial Infarction

Buring, B. Rosner, C. Hennekens, 2005 .

Human ApoA-I1 Inhibits the Hydrolysis of HDL Triglyceride and the Decrease of HDL Size Induced by Hypertriglyceridemia and Cholesteryl Ester Transfer Protein in Transgenic Mice

A. Tall, J. Breslow, Rubin, 2022 .

Two Hsp70 family members expressed in atherosclerotic lesions

J. Breslow, Q. Truong, Shirley Park, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Recipes for creating animal models of diabetic cardiovascular disease.

W. Hsueh, E. Fisher, R. McIndoe, 2007, Circulation research.

Elevating High-Density Lipoprotein Cholesterol in Apolipoprotein E—Deficient Mice Remodels Advanced Atherosclerotic Lesions by Decreasing Macrophage and Increasing Smooth Muscle Cell Content

E. Fisher, J. Fallon, J. Breslow, 2001, Circulation.

Polymorphism in the human apolipoprotein A-I gene promoter region. Association of the minor allele with decreased production rate in vivo and promoter activity in vitro.

J. Breslow, E. Brinton, J. D. Smith, 1992, The Journal of clinical investigation.

Linkage of human apolipoproteins A-I and C-III genes

J. Breslow, S. Karathanasis, V. Zannis, 1983, Nature.

Genetic markers for coronary heart disease

J. Breslow, 2001, Clinical cardiology.

Exclusion of linkage between the human apolipoprotein B gene and abetalipoproteinemia.

P. Jänne, P. Janne, J. Breslow, 1990, American journal of human genetics.

Needed: pragmatic clinical trials for statin-intolerant patients.

J. Breslow, P. Maningat, 2011, The New England journal of medicine.

Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII.

C. L. Jackson, G. Bruns, J. Breslow, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Longitudinal study shows increasing obesity and hyperglycemia in micronesia

I. Pe’er, M. Stoffel, P. Bonnen, 2013, Obesity.

Increased prebeta-high density lipoprotein, apolipoprotein AI, and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein AI transgenes.

A. Tall, J. Breslow, A. Walsh, 1996, The Journal of clinical investigation.

Lipoprotein(a) reduction by N-acetylcysteine

J. Breslow, D. Gavish, 1991, The Lancet.

Probucol decreases apolipoprotein A-I transport rate and increases high density lipoprotein cholesteryl ester fractional catabolic rate in control and human apolipoprotein A-I transgenic mice.

J. Breslow, A. Walsh, T. Hayek, 1991, Arteriosclerosis and thrombosis : a journal of vascular biology.

3T3-L1 adipocytes. mouse expression at the transcriptional level in downregulates lipoprotein lipase gene factor but not interleukin-1 alpha Recombinant human cachectin/tumor necrosis

A. Cerami, J. Breslow, B. Sherry, 2013 .

Hypertriglyceridemic mice transgenic for the human apolipoprotein C-III gene are neither insulin resistant nor hyperinsulinemic.

G. Reaven, J. Breslow, C. Mondon, 1994, Journal of lipid research.

mRN 4 in human hepatoma cell lines

J. Breslow, N. Azrolan, 2002 .

Excess dietary fructose does not alter gut microbiota or permeability in humans: A randomized controlled pilot study

K. Bittinger, W. Henderson, J. Breslow, 2020, medRxiv.

Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences.

A. Tall, J. Breslow, A. Walsh, 1992, The Journal of clinical investigation.

Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice.

A. Tall, J. Breslow, A. Walsh, 1991, The Journal of biological chemistry.

Heparin-binding defective lipoprotein lipase is unstable and causes abnormalities in lipid delivery to tissues.

H. Radner, J. Breslow, Y. Kako, 2001, The Journal of clinical investigation.

The angiotensin-II receptor antagonist, losartan, inhibits LDL lipid peroxidation and atherosclerosis in apolipoprotein E-deficient mice.

J. Breslow, T. Hayek, J. Smith, 1997, Biochemical and biophysical research communications.

HMG CoA reductase inhibitors lower LDL cholesterol without reducing Lp(a) levels.

M. Weintraub, J. Breslow, D. Gavish, 1989, Circulation.

Lovastatin reduces postprandial lipoprotein levels in hypercholesterolaemic patients with mild hypertriglyceridaemia

M. Weintraub, S. Eisenberg, J. Breslow, 1989, European journal of clinical investigation.

Hyperglycemia and Plasma Lipid Levels: Covariations in Insulin-dependent Diabetes

J. Breslow, J. Sosenko, K. Gabbay, 1982, Diabetes Care.

Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice.

J. Breslow, A. Walsh, Y. Ito, 1990, Science.

Genetic regulation of apolipoproteins.

J. Breslow, 1987, American heart journal.

An apolipoprotein CIII marker associated with hypertriglyceridemia in Caucasians also confers increased risk in a west Japanese population

J. Sasaki, J. Breslow, A. Matsunaga, 1995, Human Genetics.

Scavenger Receptor BI (SR-BI) Is Up-regulated in Adrenal Gland in Apolipoprotein A-I and Hepatic Lipase Knock-out Mice as a Response to Depletion of Cholesterol Stores

A. Tall, J. Breslow, Wei Wang, 1996, The Journal of Biological Chemistry.

Cholesteryl Ester Transfer Protein and Atherogenesis

E. Rubin, A. Tall, J. Breslow, 1997, Annals of the New York Academy of Sciences.

Profound induction of hepatic cholesteryl ester transfer protein transgene expression in apolipoprotein E and low density lipoprotein receptor gene knockout mice. A novel mechanism signals changes in plasma cholesterol levels.

A. Tall, J. Breslow, A. Walsh, 1996, The Journal of clinical investigation.

Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root.

D. Teupser, J. Breslow, J. Gutiérrez-Ramos, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Purification of arylsulfatase A from human urine.

J. Breslow, H. Sloan, 1972, Biochemical and biophysical research communications.

Purification and Properties of Two Sphingolipid Hydrolases

J. Breslow, D. Fredrickson, H. Sloan, 1972 .

[40] Intra- and extracellular modifications of apolipoproteins

J. Breslow, S. Karathanasis, V. Zannis, 1986 .

Distinguishing homozygous and heterozygous cystic fibrosis fibroblasts from normal cells by differences in sodium transport.

J. Breslow, J. Epstein, J. McPherson, 1981, The New England journal of medicine.

Identification and DNA sequence of a human apolipoprotein E cDNA clone.

J. Breslow, S. Karathanasis, A. Nussbaum, 1982, The Journal of biological chemistry.

Isolation and characterization of cDNA clones for human apolipoprotein A-I.

J. Breslow, S. Karathanasis, D. Kurnit, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Elevated high density lipoprotein cholesterol levels correlate with decreased apolipoprotein A-I and A-II fractional catabolic rate in women.

S. Eisenberg, J. Breslow, E. Brinton, 1989, The Journal of clinical investigation.

Intestinal expression of human apolipoprotein A-IV in transgenic mice fails to influence dietary lipid absorption or feeding behavior.

J. Breslow, M. Traber, A. Walsh, 1994, The Journal of clinical investigation.

Isolation and characterization of the human apolipoprotein A-I gene.

J. Breslow, S. Karathanasis, V. I. Zannis, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Abnormal apoprotein A-I isoprotein composition in patients with Tangier disease.

R. Lees, J. Breslow, A. M. Lees, 1982, The Journal of biological chemistry.

Intracellular and extracellular processing of human apolipoprotein A-I: secreted apolipoprotein A-I isoprotein 2 is a propeptide.

J. Breslow, H. Keutmann, S. Karathanasis, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Isoproteins of human apolipoprotein A-I demonstrated in plasma and intestinal organ culture.

A. Katz, J. Breslow, V. Zannis, 1980, The Journal of biological chemistry.

Hepatic apo-A-I and apo-E and intestinal apo-A-I are synthesized in precursor isoprotein forms by organ cultures of human fetal tissues.

J. Breslow, D. Kurnit, V. I. Zannis, 1982, The Journal of biological chemistry.

Antiatherosclerotic and antioxidative effects of captopril in apolipoprotein E-deficient mice.

J. Breslow, T. Hayek, J. Smith, 1998, Journal of cardiovascular pharmacology.

Induced Mutant Mice Expressing Lipoprotein Lipase Exclusively in Muscle Have Subnormal Triglycerides yet Reduced High Density Lipoprotein Cholesterol Levels in Plasma*

R. Zechner, J. Breslow, R. Ramakrishnan, 1997, The Journal of Biological Chemistry.

Heritable allele-specific differences in amounts of apoB and low-density lipoproteins in plasma.

J. Breslow, E. Brinton, D. Gavish, 1989, Science.

A regulatory element in the ApoCIII promoter that directs hepatic specific transcription binds to proteins in expressing and nonexpressing cell types.

J. Breslow, T. Leff, K. Reue, 1989, The Journal of biological chemistry.

Genetic Susceptibility to Atherosclerosis Participants

J. Lalouel, E. Schaefer, H. Tyroler, 2005 .

Apolipoprotein genes and atherosclerosis

J. Breslow, 1992, The clinical investigator.

Characterization of the mouse apolipoprotein Apoa-1/Apoc-3 gene locus: genomic, mRNA, and protein sequences with comparisons to other species.

J. Breslow, K. Aalto-Setälä, J. Januzzi, 1992, Genomics.

The genetic basis of lipoprotein disorders Introduction and overview

J. Breslow, 1992, Journal of internal medicine.

ApoA-I deficiency causes both hypertriglyceridemia and increased atherosclerosis in human apoB transgenic mice.

E. Rubin, J. Breslow, E. Voyiaziakis, 1998, Journal of lipid research.

Metabolic Determinants of Low HDL‐C Levels

S. Eisenberg, J. Breslow, E. Brinton, 1993, Annals of the New York Academy of Sciences.

A low-fat diet decreases high density lipoprotein (HDL) cholesterol levels by decreasing HDL apolipoprotein transport rates.

S. Eisenberg, J. Breslow, E. Brinton, 1990, The Journal of clinical investigation.

Delayed loss of cholesterol from a localized lipoprotein depot in apolipoprotein A-I-deficient mice.

J. Breslow, O. Stein, Y. Stein, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Dietary Fat Elevates Hepatic ApoA-I Production by Increasing the Fraction of Apolipoprotein A-I mRNA in the Translating Pool (*)

E. Fisher, J. Breslow, N. Azrolan, 1995, The Journal of Biological Chemistry.

Transgenic mouse models of lipoprotein metabolism and atherosclerosis.

J. Breslow, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of the mouse liver cell line FL83B.

V. Ferrans, J. Breslow, R. Levy, 1973, Experimental cell research.

Induction of Atherosclerosis by Low-Fat, Semisynthetic Diets in LDL Receptor–Deficient C57BL/6J and FVB/NJ Mice: Comparison of Lesions of the Aortic Root, Brachiocephalic Artery, and Whole Aorta (En Face Measurement)

D. Teupser, J. Breslow, Adam D Persky, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Clinical use of genetic typing in human lipid disorders.

C. Ballantyne, J. Breslow, W. Brown, 2012, Journal of clinical lipidology.

Hepatic Scavenger Receptor BI Promotes Rapid Clearance of High Density Lipoprotein Free Cholesterol and Its Transport into Bile*

A. Tall, J. Breslow, D. Huszar, 1999, The Journal of Biological Chemistry.

Down-regulation of mRNA for the low density lipoprotein receptor in transgenic mice containing the gene for human cholesteryl ester transfer protein. Mechanism to explain accumulation of lipoprotein B particles.

A. Tall, J. Breslow, A. Walsh, 1993, The Journal of biological chemistry.

Intestinal absorption of dietary cholesteryl ester is decreased but retinyl ester absorption is normal in carboxyl ester lipase knockout mice.

E. Harrison, E. Fisher, W. Blaner, 1999, Biochemistry.

Alternative Splicing of the Human Cholesteryl Ester Transfer Protein Gene in Transgenic Mice

A. Tall, J. Breslow, A. Walsh, 1996, The Journal of Biological Chemistry.

Lipoprotein transport gene abnormalities underlying coronary heart disease susceptibility.

J. Breslow, 1991, Annual review of medicine.

Apolipoprotein genetic variation in the assessment of atherosclerosis susceptibility

C. Robert Cloninger, R. Hegele, C. R. Cloninger, 1987, Genetic epidemiology.

Expression of the human apolipoprotein A-I gene in transgenic mice alters high density lipoprotein (HDL) particle size distribution and diminishes selective uptake of HDL cholesteryl esters.

J. Breslow, A. Walsh, T. Hayek, 1991, Proceedings of the National Academy of Sciences of the United States of America.

A solution hybridization/RNase protection assay with riboprobes to determine absolute levels of apoB, A-I, and E mRNA in human hepatoma cell lines.

J. Breslow, N. Azrolan, 1990, Journal of lipid research.

Methylation changes in the apolipoprotein AI gene during embryonic development of the mouse.

S. Eisenberg, A. Razin, J. Breslow, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Antibodies to PCSK9: a superior way to lower LDL cholesterol?

J. Breslow, K. Maxwell, 2012, Circulation research.

Proprotein convertase subtilisin kexin 9: the third locus implicated in autosomal dominant hypercholesterolemia

J. Breslow, K. Maxwell, 2005, Current opinion in lipidology.

The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6

Rachel M. Adams, S. Burley, J. Breslow, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Apolipoprotein E gene expression in mouse 3T3-L1 adipocytes and human adipose tissue and its regulation by differentiation and lipid content.

R. Zechner, J. Breslow, S. Fried, 1991, The Journal of biological chemistry.

Homozygous Familial Hypercholesterolemia

R. Lees, J. Breslow, R. Levy, 1975 .

Effect of lipoprotein on 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase activity in rat liver cell culture: special suppressant effect of a lipoprotein isolated from hypercholesterolemic rat plasma.

J. Breslow, A. Clowes, D. R. Spaulding, 1975, Biochemical and biophysical research communications.

A unique AT-rich hypervariable minisatellite 3' to the ApoB gene defines a high information restriction fragment length polymorphism.

J. Breslow, L. Huang, 1987, The Journal of biological chemistry.

Cardiovascular disease myths and facts.

J. Breslow, 1998, Cleveland Clinic journal of medicine.

ApoB gene nonsense and splicing mutations in a compound heterozygote for familial hypobetalipoproteinemia.

J. Breslow, R. Sokol, L. Huang, 1991, Journal of lipid research.

Lipoprotein lipase expression exclusively in liver. A mouse model for metabolism in the neonatal period and during cachexia.

H. Radner, J. Breslow, I. Goldberg, 1998, The Journal of clinical investigation.

Induced mutant mouse lines that express lipoprotein lipase in cardiac muscle, but not in skeletal muscle and adipose tissue, have normal plasma triglyceride and high-density lipoprotein-cholesterol levels.

R. Zechner, H. Radner, J. Breslow, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Very low density lipoproteins stimulate cholesteryl ester formation in U937 macrophages. Heterogeneity and biologic variation among normal humans.

F. Sacks, J. Breslow, 1987, Arteriosclerosis.

Plasma Ip(a) concentration is inversely correlated with the ratio of Kringle IV/Kringle V encoding domains in the apo(a) gene.

J. Breslow, D. Gavish, N. Azrolan, 1989, The Journal of clinical investigation.

Lack of an effect of dairy protein (casein) and soy protein on plasma cholesterol of strict vegetarians. An experiment and a critical review.

F. Sacks, J. Breslow, E. Kass, 1983, Journal of lipid research.

STARD4 knockdown in HepG2 cells disrupts cholesterol trafficking associated with the plasma membrane, ER, and ERC

F. Maxfield, J. Breslow, J. Garbarino, 2012, Journal of Lipid Research.

Targeted disruption of steroidogenic acute regulatory protein D4 leads to modest weight reduction and minor alterations in lipid metabolism[S]

Marc P. Waase, J. Breslow, J. Garbarino, 2010, Journal of Lipid Research.

Insights into lipoprotein metabolism from studies in transgenic mice.

J. Breslow, 1994, Annual review of physiology.

Apolipoprotein Gene Mutations, Dyslipoproteinemia and Coronary Heart Disease

J. Breslow, 1987 .

Genetics of Lipoprotein Disorders

J. Breslow, 1993, Circulation.

Human apolipoprotein molecular biology and genetic variation.

J. Breslow, 1985, Annual review of biochemistry.

Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprits⃞ Published, JLR Papers in Press, June 8, 2006.

J. Breslow, E. M. Duncan, I. Björkhem, 2006, Journal of Lipid Research.

Human apolipoprotein CIII gene expression is regulated by positive and negative cis-acting elements and tissue-specific protein factors.

J. Breslow, T. Leff, K. Reue, 1988, The Journal of biological chemistry.

Type of alcoholic beverage and risk of myocardial infarction.

J. Buring, R. Glynn, C. Hennekens, 1999, The American journal of cardiology.

Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction.

W. Willett, J. Buring, B. Rosner, 1993, The New England journal of medicine.

Isolation of cDNA and genomic clones for apolipoprotein C-II.

C. L. Jackson, G. Bruns, J. Breslow, 1986, Methods in enzymology.

Effects of streptozotocin-induced diabetes in apolipoprotein AI deficient mice.

J. Breslow, I. Goldberg, E. Sehayek, 2004, Atherosclerosis.

Ultrastructure of early lipid accumulation in ApoE-deficient mice.

J. Qiao, J. Breslow, J. Frank, 1999, Arteriosclerosis, thrombosis, and vascular biology.

Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice.

P. Milos, J. Breslow, P. Bourassa, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Molecular basis of five apolipoprotein B gene polymorphisms in noncoding regions.

J. Breslow, L. Huang, M. Ripps, 1990, Journal of lipid research.

ApoB gene MspI RFLP in exon 26 changes amino acid 3611 from Arg to Gln.

J. Breslow, L. Huang, J. de Graaf, 1988, Journal of lipid research.

Pediatric aspects of hyperlipidemia.

J. Breslow, 1978, Pediatrics.

Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae

Benjamin M. Neale, Itsik Pe'er, Julian B. Maller, 2009, PLoS genetics.

Characterization of the apolipoprotein A-I-C-III gene complex.

J. Breslow, S. Karathanasis, V. I. Zannis, 1986, Methods in enzymology.

Genetic basis of lipoprotein disorders.

J. Breslow, M. Dammerman, 1989, Circulation.

Dihydropteridine reductase deficiency associated with severe neurologic disease and mild hyperphenylalaninemia.

M. Moskowitz, S. Milstien, J. Breslow, 1979, Pediatrics.

Phytosterolemia on the island of Kosrae: founder effect for a novel ABCG8 mutation results in high carrier rate and increased plasma plant sterol levels.

M. Stoffel, J. Salit, M. Blundell, 2004, Journal of lipid research.

Effect of fosinopril and vitamin E on LDL peroxidation and atheroclerosis progression in apo E-deficient mice

J. Breslow, T. Hayek, S. Keidar, 1995 .

A complex plasma plant sterol locus on mouse chromosome 14 has at least two genes regulating intestinal sterol absorption Published, JLR Papers in Press, July 13, 2006.

D. Teupser, J. Breslow, U. Ceglarek, 2006, Journal of Lipid Research.

Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype.

J. Breslow, K. Maxwell, Jan L Breslow, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Cholesterol feeding of mice expressing cholesterol 7α-hydroxylase increases bile acid pool size despite decreased enzyme activity

M. Tiemann, J. Breslow, R. Soccio, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Apolipoprotein E regulates dietary cholesterol absorption and biliary cholesterol excretion: studies in C57BL/6 apolipoprotein E knockout mice.

J. Breslow, M. Merkel, E. Sehayek, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Lipoprotein lipase regulates Fc receptor-mediated phagocytosis by macrophages maintained in glucose-deficient medium.

J. Breslow, Y. Kako, J. Loike, 1997, The Journal of clinical investigation.

Effects of shrimp consumption on plasma lipoproteins.

F. Sacks, J. Breslow, L. Hudgins, 1996, The American journal of clinical nutrition.

Accumulation of human apolipoprotein E in the plasma of transgenic mice.

J. Breslow, A. Walsh, A. Plump, 1990, The Journal of biological chemistry.

A randomized clinical trial in vitamin D-deficient adults comparing replenishment with oral vitamin D3 with narrow-band UV type B light: effects on cholesterol and the transcriptional profiles of skin and blood.

Dong Joo Kim, Yupu Liang, I. Barash, 2017, The American journal of clinical nutrition.

N-acetylcysteine and lipoprotein(a)

J. Breslow, A. Bostom, N. Azrolan, 1992, The Lancet.

Steroid hormone toxicity in human fibroblasts does not correlate with high affinity receptor content

G. Forbes, J. Breslow, J. Epstein, 1979, Journal of cellular physiology.

Dexamethasone-resistant cystic fibrosis fibroblasts show cross-resistance to sex steroids

J. Breslow, J. Epstein, J. H. Fontaine, 1978, Cell.

Human Apolipoprotein A‐I‐C‐III Gene Complex is Located on Chromosome II

G. Bruns, J. Breslow, S. Karathanasis, 1984, Arteriosclerosis.

Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse.

R. Ross, Y. Nakashima, J. Breslow, 1998, Arteriosclerosis, thrombosis, and vascular biology.

Genetic Modifiers of Atherosclerosis in Mice

Jonathan D. Smith, J. Breslow, H. Dansky, 2001, Annals of the New York Academy of Sciences.

Apolipoprotein C-III0 lacks carbohydrate residues: use of mass spectrometry to study apolipoprotein structure.

B. Chait, J. Breslow, Y. Ito, 1989, Journal of lipid research.

Altered Expression of Raet1e , an MHC Class 1–Like Molecule, Underlies the Atherosclerosis Modifier Locus Ath11 10b

D. Teupser, J. Breslow, M. Robblee, 2013 .

Plasma lipoprotein(a) concentration is controlled by apolipoprotein(a) (apo(a)) protein size and the abundance of hepatic apo(a) mRNA in a cynomolgus monkey model.

J. Breslow, D. Gavish, N. Azrolan, 1991, The Journal of biological chemistry.

Characterization of a unique human apolipoprotein E variant associated with type III hyperlipoproteinemia.

J. Breslow, V. I. Zannis, 1980, The Journal of biological chemistry.

Lipoprotein regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in rat liver cell cultures.

J. Breslow, A. Clowes, S. Lux, 1977, The Journal of biological chemistry.

Hypobetalipoproteinemia due to an apolipoprotein B gene exon 21 deletion derived by Alu-Alu recombination.

S. Korman, J. Breslow, R. Deckelbaum, 1989, The Journal of biological chemistry.

Alternative polyadenylation of apolipoprotein B RNA is a major cause of B-48 protein formation in rat hepatoma cell lines transfected with human apoB-100 minigenes.

E. Fisher, J. Breslow, T. Heinemann, 1994, Journal of lipid research.

The structure of the mouse lipoprotein lipase gene: a B1 repetitive element is inserted into the 3' untranslated region of the mRNA.

J. Breslow, T. Newman, R. Zechner, 1991, Genomics.

Cell type-specific expression of the human apoB gene is controlled by two cis-acting regulatory regions.

J. Breslow, T. Leff, H. Das, 1988, The Journal of biological chemistry.

Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis

J. Breslow, K. Hajjar, R. Nachman, 1989, Nature.

Orphan receptor HNF-4 and bZip protein C/EBP alpha bind to overlapping regions of the apolipoprotein B gene promoter and synergistically activate transcription.

F. Sladek, J. Breslow, J. Halaas, 1993, The Journal of biological chemistry.

The angiotensin-converting enzyme inhibitor, fosinopril, and the angiotensin II receptor antagonist, losartan, inhibit LDL oxidation and attenuate atherosclerosis independent of lowering blood pressure in apolipoprotein E deficient mice.

R. Coleman, J. Breslow, S. Brodsky, 1999, Cardiovascular research.

Relation between systemic hypertension and blood lipids on the risk of myocardial infarction.

J. Buring, C. Hennekens, H. Sesso, 1999, The American journal of cardiology.

Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia.

J. Breslow, T. Leff, L., 1995, The Journal of clinical investigation.

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

G. Shulman, J. Breslow, Y. Kako, 2001, Proceedings of the National Academy of Sciences of the United States of America.

[120] Cerebroside sulfate sulfatase (arylsulfatase A) from human urine

J. Breslow, H. Sloan, 1972 .

Characterization of the major apolipoproteins secreted by two human hepatoma cell lines.

J. Breslow, B. Knowles, D. Aden, 1981, Biochemistry.

Candidate genes involved in cardiovascular risk factors by a family-based association study on the island of Kosrae, Federated States of Micronesia.

Wentian Li, J. Ott, S. Heath, 2002, American journal of medical genetics.

Enhanced dexamethasone resistance in cystic fibrosis cells: potential use for heterozygote detection and prenatal diagnosis.

G. Forbes, J. Breslow, J. Epstein, 1978, Science.

Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production.

J. Breslow, A. Plump, D. Williams, 1996, The Journal of clinical investigation.

Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain

Stephen K. Burley, S. Burley, J. Breslow, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4).

S. Burley, J. Breslow, R. Soccio, 2002 .

Absence of enhanced intimal thickening in the response of the carotid arterial wall to endothelial injury in hypercholesterolemic rats.

J. Breslow, A. Clowes, M. Karnovsky, 1976, Laboratory investigation; a journal of technical methods and pathology.

Further characterization of the metabolic properties of triglyceride-rich lipoproteins from human and mouse apoC-III transgenic mice.

J. Breslow, P. Weinstock, C. Bisgaier, 1996, Journal of lipid research.

Mouse Models of Atherosclerosis

J. Breslow, 1996, Science.

Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles.

Henry N. Ginsberg, R. Zechner, J. Breslow, 1992, The Journal of clinical investigation.

Synthesis, intracellular processing, and signal peptide of human apolipoprotein E.

J. Breslow, S. Karathanasis, G. Goldberger, 1984, The Journal of biological chemistry.

Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes.

R J Havel, R. Mahley, R. Havel, 1982, Journal of lipid research.

The protective effect of A20 on atherosclerosis in apolipoprotein E-deficient mice is associated with reduced expression of NF-κB target genes

D. Teupser, J. Breslow, M. Tan, 2007, Proceedings of the National Academy of Sciences.

A20, a regulator of NFκB, maps to an atherosclerosis locus and differs between parental sensitive C57BL/6J and resistant FVB/N strains

J. Breslow, Hayes M. Dansky, Jan L. Breslow, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron.

C. L. Jackson, D. Miller, J. Breslow, 1987, Journal of Biological Chemistry.

TRIB1, chromosome 8 and the regulation of blood lipids

J. Breslow, R. Burkhardt, 2011 .

Common SNPs in HMGCR in Micronesians and Whites Associated With LDL-Cholesterol Levels Affect Alternative Splicing of Exon13

M. Daly, D. Altshuler, I. Pe’er, 2008, Arteriosclerosis, thrombosis, and vascular biology.

DASH: a method for identical-by-descent haplotype mapping uncovers association with recent variation.

Alexander Gusev, Richa Saxena, Itsik Pe'er, 2011, American journal of human genetics.

A phenotype-sensitizing Apoe-deficient genetic background reveals novel atherosclerosis predisposition loci in the mouse.

G. Duyk, Jonathan D. Smith, J. Breslow, 2002, Genetics.

Genetic differences in endothelial cells may determine atherosclerosis susceptibility.

J. Breslow, 2000, Circulation.

Genetic background determines the extent of atherosclerosis in ApoE-deficient mice.

S. Heath, J. Breslow, K. J. Moore, 1999, Arteriosclerosis, thrombosis, and vascular biology.

Fecal microbiota and bile acid interactions with systemic and adipose tissue metabolism in diet-induced weight loss of obese postmenopausal women

Nicholas A. Bokulich, M. Blaser, Yupu Liang, 2018, Journal of Translational Medicine.

Characterization of an Enhancer Element in the Human Apolipoprotein C-III Gene That Regulates Human Apolipoprotein A-I Gene Expression in the Intestinal Epithelium (*)

J. Gordon, J. Breslow, T. C. Simon, 1995, The Journal of Biological Chemistry.

Apolipoprotein genetic variation and human disease.

J. Breslow, 1988, Physiological reviews.

Sequence and expression of Tangier apoA-I gene.

J. Breslow, A. Nussbaum, S. Makrides, 1988, European journal of biochemistry.

Liver Receptor Homologue-1 Mediates Species- and Cell Line-specific Bile Acid-dependent Negative Feedback Regulation of the Apical Sodium-dependent Bile Acid Transporter*

P. Dawson, J. Breslow, F. Gonzalez, 2003, Journal of Biological Chemistry.

Effects of prostaglandin E1 and isoproterenol on cyclic AMP content of human fibroblasts modified by time and cell density in subculture.

J. Breslow, V. Manganiello, 1974, Biochimica et biophysica acta.

Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae Citation Lowe

M. Daly, D. Altshuler, B. Neale, 2009 .

n-3 fatty acids and cardiovascular disease.

J. Breslow, 2006, The American journal of clinical nutrition.

Human apolipoprotein B cDNA clone isolation and demonstration that liver apolipoprotein B mRNA is 22 kilobases in length.

J. Breslow, L. Huang, J L Breslow, 1985, Proceedings of the National Academy of Sciences of the United States of America.

CYSTIC FIBROSIS: A DISORDER OFCALCIUM-STIMULATED SECRETION AND TRANSEPITHELIAL SODIUM TRANSPORT?

J. Breslow, E. Sorscher, 1982, The Lancet.

Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia

Itsik Pe'er, Mark J Daly, Richard P Lifton, 2006, Nature Genetics.

Human osteogenic sarcoma cells exhibit enhanced protein phosphorylation.

J. Breslow, J. Epstein, 1981, Biochimica et biophysica acta.

Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice.

R. Stollberger, R. Zechner, H. Radner, 1995, The Journal of clinical investigation.

ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes.

A. Tall, S. Eisenberg, J. Breslow, 1997, Journal of lipid research.

Transcriptional regulation of the apoC-III gene by insulin in diabetic mice: correlation with changes in plasma triglyceride levels.

J. Breslow, T. Leff, T Leff, 1994, Journal of lipid research.

Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population.

Eleazar Eskin, Alexander Gusev, Minseung Kim, 2011, Human molecular genetics.

Genomewide association studies and lipid risk factors

E. Kenny, J. Breslow, R. Burkhardt, 2009 .

Linkage analysis of quantitative traits for obesity, diabetes, hypertension, and dyslipidemia on the island of Kosrae, Federated States of Micronesia.

S. Heath, M. Stoffel, J. Salit, 2006, Proceedings of the National Academy of Sciences of the United States of America.

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

R. Ross, R. Ross, Y. Nakashima, 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

Altered Expression of Raet1e, a Major Histocompatibility Complex Class 1–Like Molecule, Underlies the Atherosclerosis Modifier Locus Ath11 10b

D. Teupser, J. Breslow, Jae-Hoon Choi, 2013, Circulation research.

Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- mice.

D. Teupser, J. Breslow, M. Tan, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model

A. Tall, J. Breslow, C. Welch, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae.

M. Daly, D. Altshuler, J. Maller, 2009, Heart rhythm.

Hepatocyte nuclear factor-1α is an essential regulator of bile acid and plasma cholesterol metabolism

M. Stoffel, F. Suchy, J. Breslow, 2001, Nature Genetics.

Isolation and characterization of cDNA clones corresponding to two different human apoC-III alleles.

J. Breslow, S. Karathanasis, V. I. Zannis, 1985, Journal of lipid research.

Identification of quantitative trait loci affecting body composition in a mouse intercross

J. Breslow, E. Sehayek, James A Vitarius, 2006, Proceedings of the National Academy of Sciences.

European admixture on the Micronesian island of Kosrae: lessons from complete genetic information

D. Altshuler, I. Pe’er, M. Stoffel, 2009, European Journal of Human Genetics.

Systematic haplotype analysis resolves a complex plasma plant sterol locus on the Micronesian Island of Kosrae

Alexander Gusev, Itsik Pe'er, Jacqueline Salit, 2009, Proceedings of the National Academy of Sciences.

Cholesterol, 7-ketocholesterol and 25-hydroxycholesterol uptake studies and effect on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in human fibroblasts.

J. Breslow, A. Kandutsch, D. R. Spaulding, 1975, Biochimica et biophysica acta.

Epidemiology and Factor Analysis of Obesity, Type II Diabetes, Hypertension, and Dyslipidemia (Syndrome X) on the Island of Kosrae, Federated States of Micronesia

Thomas Lehner, J. Ott, S. Heath, 2000, Human Heredity.

Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment.

E. Fisher, J. Breslow, K. Maxwell, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Effects of Rapid Weight Loss on Systemic and Adipose Tissue Inflammation and Metabolism in Obese Postmenopausal Women

C. Hudis, Yupu Liang, A. Dannenberg, 2017, Journal of the Endocrine Society.

High-Density Lipoproteins Retard the Progression of Atherosclerosis and Favorably Remodel Lesions Without Suppressing Indices of Inflammation or Oxidation

John T. Fallon, E. Fisher, J. Fallon, 2004, Arteriosclerosis, thrombosis, and vascular biology.

The emergence of mouse models of atherosclerosis and their relevance to clinical research

J. Breslow, J. D. Smith, J. Smith, 1997, Journal of internal medicine.

Apolipoprotein B-gene DNA polymorphisms associated with myocardial infarction.

J. Buring, C. Hennekens, R. Hegele, 1986, The New England journal of medicine.

Genetics of lipoprotein abnormalities associated with coronary artery disease susceptibility.

J. Breslow, 2000, Annual review of genetics.

Apolipoprotein E and the apolipoprotein E-deficient mouse.

J. Breslow, A. Plump, 1995, Annual review of nutrition.

Noninvasive In vivo high-resolution magnetic resonance imaging of atherosclerotic lesions in genetically engineered mice.

E A Fisher, V. Fuster, Z. Fayad, 1998, Circulation.

Quantitative Trait Locus Mapping of Genetic Modifiers of Metabolic Syndrome and Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice: Identification of a Locus for Metabolic Syndrome and Increased Atherosclerosis on Chromosome 4

A. Tall, J. Breslow, C. Welch, 2004, Arteriosclerosis, thrombosis, and vascular biology.

In Silico Quantitative Trait Locus Map for Atherosclerosis Susceptibility in Apolipoprotein E–Deficient Mice

K. Wittkowski, Jonathan D. Smith, J. Breslow, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse.

R. Ross, Y. Nakashima, J. Breslow, 1998, Arteriosclerosis, Thrombosis and Vascular Biology.

Athsq1 Is an Atherosclerosis Modifier Locus With Dramatic Effects on Lesion Area and Prominent Accumulation of Versican

A. Tall, D. Teupser, J. Breslow, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Chapter 12 Lipoprotein genetics and molecular biology

J. Breslow, 1987 .

Isolation and characterization of the apolipoprotein genes.

J. Breslow, 1985, Advances in experimental medicine and biology.

Molecular genetics of lipoprotein disorders.

J. Breslow, 1984, Circulation.

Human HDL cholesterol levels are determined by apoA-I fractional catabolic rate, which correlates inversely with estimates of HDL particle size. Effects of gender, hepatic and lipoprotein lipases, triglyceride and insulin levels, and body fat distribution.

S. Eisenberg, J. Breslow, E. Brinton, 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

Improved survival of patients with homozygous familial hypercholesterolaemia treated with plasma exchange.

J. Breslow, G. Thompson, J. Miller, 1985, British medical journal.

Plasma-exchange therapy of homozygous familial hypercholesterolemia.

R. Lees, M. E. King, J. Breslow, 1980, The New England journal of medicine.

Dietary polyunsaturated fats of the W-6 and W-3 series reduce postprandial lipoprotein levels. Chronic and acute effects of fat saturation on postprandial lipoprotein metabolism.

R. Zechner, M. Weintraub, S. Eisenberg, 1988, The Journal of clinical investigation.

How Do We Improve Patient Compliance and Adherence to Long-Term Statin Therapy?

J. Breslow, B. Gordon, P. Maningat, 2012, Current Atherosclerosis Reports.

Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice.

S. Akira, D. Rader, S. Kathiresan, 2010, The Journal of clinical investigation.

Human apolipoprotein E isoprotein subclasses are genetically determined.

J. Breslow, P. Just, V. I. Zannis, 1981, American journal of human genetics.

Alcohol Consumption Raises HDL Cholesterol Levels by Increasing the Transport Rate of Apolipoproteins A-I and A-II

Jonathan D. Smith, J. Breslow, D. Foster, 2000, Circulation.

Clinical utility of lipid and lipoprotein levels during hospitalization for acute myocardial infarction

J. Buring, S. Satterfield, C. Hennekens, 1999, Vascular medicine.

U-shape relationship between change in dietary cholesterol absorption and plasma lipoprotein responsiveness and evidence for extreme interindividual variation in dietary cholesterol absorption in humans.

J. Breslow, T. Heinemann, E. Sehayek, 1998, Journal of lipid research.

Decreased HDL2 and HDL3 Cholesterol, Apo A‐I and Apo A‐II, and Increased Risk of Myocardial Infarction

J. Buring, B. Rosner, C. Hennekens, 1992, Circulation.

Lovastatin efficacy in reducing low-density lipoprotein cholesterol levels on high- vs low-fat diets.

J. Breslow, M. Cobb, H. Teitelbaum, 1991, JAMA.

Effects of a low fat diet with and without intermittent saturated fat and cholesterol ingestion on plasma lipid, lipoprotein, and apolipoprotein levels in normal volunteers.

M. Denke, J. Breslow, 1988, Journal of lipid research.

Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E.

M. Weintraub, S. Eisenberg, J. Breslow, 1987, The Journal of clinical investigation.

Sequence polymorphism in the human apoB gene at position 8344.

J. Breslow, L. Huang, D. Gavish, 1990, Nucleic acids research.

Inference of a molecular defect of apolipoprotein B in hypobetalipoproteinemia by linkage analysis in a large kindred.

M. Leppert, P. O'Connell, M. Lathrop, 1988, The Journal of clinical investigation.

Genetic basis of lipoprotein disorders.

J. Breslow, M. Dammerman, 1995, The Journal of clinical investigation.

Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2.

C. Glueck, J. Breslow, T. Tracy, 1982, Journal of lipid research.

Serum stimulation of CCR7 chemotaxis due to coagulation factor XIIa-dependent production of high-molecular-weight kininogen domain 5

J. Breslow, M. Ponda, 2016, Proceedings of the National Academy of Sciences.

Plasma plant sterol levels: another coronary heart disease risk factor?

J. Breslow, E. Sehayek, 2005, Arteriosclerosis, thrombosis, and vascular biology.

Plasma and hepatic apoE isoproteins of nonhuman primates. Differences in apoE among humans, apes, and New and Old World monkeys.

J. Breslow, R. Nicolosi, K. Hayes, 1985, Journal of lipid research.

Docosahexaenoic Acid Supplementation is Not Anti-Inflammatory in Adipose Tissue of Healthy Obese Postmenopausal Women.

C. Hudis, Yupu Liang, Caroline S. Jiang, 2017, International journal of nutrition.

Physical exercise and reduced risk of nonfatal myocardial infarction.

W. Willett, R. Paffenbarger, C. Hennekens, 1995, American journal of epidemiology.

Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mices⃞s⃞ The online version of this article (available at http://www.jlr.org) contains one supplemental table. Published, JLR Papers in Press, August 1, 2003. DOI 10.1194/jlr.M300203-JLR200

J. Breslow, E. M. Duncan, R. Soccio, 2003, Journal of Lipid Research.

Cardiovascular disease burden increases, NIH funding decreases

J. Breslow, Jan L. Breslow, 1997, Nature Medicine.

Vitamin D3 Repletion in Chronic Kidney Disease Stage 3: Effects on Blood Endotoxin Activity, Inflammatory Cytokines, and Intestinal Permeability

J. Breslow, M. Ponda, 2013, Renal failure.

Learning experiences during the internship year: an exploratory study of pediatric graduate education.

J. Breslow, J. Alpert, J. Kosa, 1973, Pediatrics.

Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice[S]

J. Breslow, Nakesha King, Changcheng Zhou, 2009, Journal of Lipid Research.

Biliary cholesterol excretion: a novel mechanism that regulates dietary cholesterol absorption.

A. Tall, J. Breslow, E. Sehayek, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Localization of the PE methylation pathway and SR-BI to the canalicular membrane: evidence for apical PC biosynthesis that may promote biliary excretion of phospholipid and cholesterol.

B. Chait, D. Vance, J. Breslow, 2003, Journal of lipid research.

Familial aggregation of total cholesterol, high density lipoprotein cholesterol and total triglyceride levels in plasma.

J. Breslow, J. Sosenko, O. Miettinen, 1980, American journal of epidemiology.

Increased ADAM 17 mRNA Expression and Activity Is Associated With Atherosclerosis Resistance in LDL-Receptor Deficient Mice

L. Holdt, D. Teupser, J. Breslow, 2008 .

Obesity and ethnicity alter gene expression in skin

D. Butler, J. Breslow, J. Swann, 2020, Scientific Reports.

Obesity and Race Alter Gene Expression in Skin

J. Breslow, J. Swann, S. Garcet, 2020, medRxiv.

Noninvasive Detection of Inflammatory Changes in White Adipose Tissue by Label-Free Raman Spectroscopy.

C. Hudis, M. Morrow, I. Barman, 2016, Analytical chemistry.

The pregnane X receptor (PXR; also known as steroid and xenobiotic receptor, or SXR) is a nuclear hormone receptor activated by xenobiotics as well as diverse sterols

J. Breslow, Nakesha King, Changcheng Zhou, 2009 .

Preparation of individual human diploid fibroblasts and study of ion transport.

J. Breslow, C. Lechene, E. Abraham, 1985, The American journal of physiology.

ApoE distribution among lipoproteins of rhesus monkeys is modulated by dietary fat and cholesterol.

J. Breslow, K. Hayes, E. Zanni, 1986, The Journal of nutrition.

Why You Should Support the American Heart Association! Presented at the 69th Scientific Sessionsof the American Heart AssociationNovember 10, 1996New Orleans, Louisiana

J. Breslow, 1996 .

A prospective study of the association between APOE genotype and the risk of myocardial infarction among apparently healthy men.

P. Ridker, M. Stampfer, Simin Liu, 2003, Atherosclerosis.

Perspective on the 2013 American Heart Association/American College of Cardiology guideline for the use of statins in primary prevention of low-risk individuals.

J. Breslow, 2014, Circulation research.

High density lipoprotein and heart disease: induced mutant mouse studies.

J. Breslow, 1996, Israel journal of medical sciences.

Elizabeth R. De Oliveira e Silva, David Foster, Monnie McGee Harper, Cynthia E. Transport Rate of Apolipoproteins A-I and A-II Alcohol Consumption Raises HDL Cholesterol Levels by Increasing the

J. Breslow, E. Brinton, J. Smith, 2006 .

Regression of myointimal thickening following carotid endothelial injury and development of aortic foam cell lesions in long term hypercholesterolemic rats.

J. Breslow, M. Karnovsky, A. Clowes, 1977, Laboratory investigation; a journal of technical methods and pathology.

The Mouse Atherosclerosis Locus at Chromosome 10 (Ath11) Acts Early in Lesion Formation With Subcongenic Strains Delineating 2 Narrowed Regions

D. Teupser, J. Breslow, M. Tan, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Excess dietary fructose does not alter gut microbiota or permeability in humans: A pilot randomized controlled study

K. Bittinger, W. Henderson, J. Breslow, 2021, Journal of Clinical and Translational Science.

The Short-Term Effects of Vitamin D Repletion on Cholesterol: A Randomized, Placebo-Controlled Trial

J. Breslow, K. Dowd, P. Holt, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae.

M. Daly, D. Altshuler, J. Maller, 2009, Heart rhythm.

Independent effects of dietary saturated fat and cholesterol on plasma lipids, lipoproteins, and apolipoprotein E.

E. Fisher, C. Blum, J. Breslow, 1983, Journal of lipid research.

Pleiotropic drug resistance in cystic fibrosis fibroblasts: Increased resistance to cyclic AMP

J. Breslow, M. Vayo, J. Epstein, 1978, Somatic cell genetics.

Loci controlling plasma non-HDL and HDL cholesterol levels in a C57BL /6J x CASA /Rk intercross.

J. Breslow, E. M. Duncan, L. Petukhova, 2003, Journal of lipid research.

Sodium transport in cystic-fibrosis-fibroblast not different from normal.

J. Breslow, J. McPherson, 1981, New England Journal of Medicine.

Sodium transport in cystic fibrosis fibroblasts.

T. Boat, R. Stern, J. Breslow, 1981, New England Journal of Medicine.

Decreased ouabain binding in cystic fibrosis fibroblasts in potassium-free medium.

J. Breslow, M. Vayo, J. Epstein, 1977, Experimental cell research.

Increased dexamethasone resistance of cystic fibrosis fibroblasts.

J. Breslow, R. Davidson, J. Epstein, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Increased resistance of cystic fibrosis fibroblasts to ouabain toxicity.

J. Breslow, J. Epstein, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Differential killing of normal and cystic fibrosis fibroblasts by dexamethasone.

J. Breslow, J. Epstein, 1980, Science.

A novel missense mutation in the gene for lipoprotein lipase resulting in a highly conservative amino acid substitution (Asp180-->Glu) causes familial chylomicronemia (type I hyperlipoproteinemia).

G. Höfler, J. Breslow, S. Fried, 1993, Genomics.

Low-Pass Genome-Wide Sequencing and Variant Inference Using Identity-by-Descent in an Isolated Human Population

M. Lyons, I. Pe’er, H. Peckham, 2012, Genetics.

Comparison of Hypochromic Effect and Optical Rotation in Poly-L-glutamic Acid

J. Applequist, J. Breslow, 1963 .

Lipoproteins and Heart Disease

J. Breslow, 1994, Bio/Technology.

Plasma Plant Sterol Levels

J. Breslow, E. Sehayek, 2004 .

Hyodeoxycholic acid efficiently suppresses atherosclerosis formation and plasma cholesterol levels in mice.

J. Breslow, E. M. Duncan, M. Lipkin, 2001, Journal of lipid research.

Increased apo A-I and apo A-II fractional catabolic rate in patients with low high density lipoprotein-cholesterol levels with or without hypertriglyceridemia.

S. Eisenberg, J. Breslow, E. Brinton, 1991, The Journal of clinical investigation.

Isolation and characterization of cDNA clones corresponding to two different human apoC-l I I alleles

J. Breslow, S. Karathanasis, V. Zannis, 2002 .

Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice[S]

J. Breslow, Nakesha King, Changcheng Zhou, 2009, Journal of Lipid Research.

Vitamin D May Not Improve Lipid Levels: A Serial Clinical Laboratory Data Study

J. Breslow, H. Kaufman, Mouneer A. Odeh, 2012, Circulation.

Vitamin D-binding protein levels do not influence the effect of vitamin D repletion on serum PTH and calcium: data from a randomized, controlled trial.

J. Breslow, M. Ponda, D. McGee, 2014, The Journal of clinical endocrinology and metabolism.

Apolipoprotein E

J. Breslow, V. Zannis, 2004, Molecular and Cellular Biochemistry.

Needed: pragmatic clinical trials for statin-intolerant patients.

J. Breslow, P. Maningat, 2011, The New England journal of medicine.

Lipoprotein metabolism and atherosclerosis susceptibility in transgenic mice.

J. Breslow, 1994, Current opinion in lipidology.

Identification of two isoforms of the catalytic subunit of Na,K-ATPase in myocytes from adult rat heart.

P. Christen, G. Lienhard, M. Yamaguchi, 1987, The Journal of biological chemistry.