J. McDonald

M. Stefanick, J. McDonald, Bonne M. Thompson, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Uptake of HDL-cholesterol contributes to lipid accumulation in clear cell renal cell carcinoma.

Y. Lotan, J. McDonald, Bonne M. Thompson, 2019, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

J. Mendell, J. McDonald, J. Goldstein, 2020, Proceedings of the National Academy of Sciences.

Diverse species-specific phenotypic consequences of loss of function sorting nexin 14 mutations

Thomas A. Hawkins, M. Bitner-Glindzicz, J. Rihel, 2019, Scientific Reports.

Biliopancreatic Diversion Induces Greater Metabolic Improvement Than Roux-en-Y Gastric Bypass.

Mohit M. Jain, S. Klein, J. McDonald, 2019, Cell metabolism.

Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice

J. McDonald, R. Unger, May-yun Wang, 2018, Cell reports.

FAF1 blocks ferroptosis by inhibiting peroxidation of polyunsaturated fatty acids.

Glenn E. Simmons, J. McDonald, Jin Ye, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice

R. Hammer, J. McDonald, J. Horton, 2017, eLife.

Measurement of lipogenic flux by deuterium resolved mass spectrometry

J. McDonald, J. Horton, S. Burgess, 2021, Nature Communications.

Title : 1 Proximity labeling of Snx 14 reveals a functional interaction with Δ-9 2 desaturase SCD 1 to maintain ER homeostasis

J. McDonald, H. Hariri, Jade Bowerman, 2020 .

Insights into lipid accumulation in skeletal muscle in dysferlin-deficient mice[S]

A. Garg, J. McDonald, Matthew A. Mitsche, 2019, Journal of Lipid Research.

Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans

N. Grishin, B. Faubert, R. Deberardinis, 2019, Cell reports.

Liver X receptors regulate adrenal cholesterol balance.

D. Mangelsdorf, J. McDonald, Y. Zhang, 2006, The Journal of clinical investigation.

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.

C. Glass, R. Germain, R. Evans, 2020, Immunity.

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP pathways in macrophages

Matthew S. Tremblay, C. Glass, N. Spann, 2017, bioRxiv.

Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice

J. McDonald, Bonne M. Thompson, Y. Jo, 2019, eLife.

Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver*

J. McDonald, Matthew A. Mitsche, R. DeBose-Boyd, 2016, The Journal of Biological Chemistry.

Diabetes and insulin in regulation of brain cholesterol metabolism.

T. Montine, C. Kahn, S. Craft, 2010, Cell metabolism.

Distinct oxysterol requirements for positioning naïve and activated dendritic cells in the spleen

J. Cyster, J. McDonald, Erick Lu, 2017, Science Immunology.

MMAB promotes negative feedback control of cholesterol homeostasis

M. A. Lasunción, G. Shulman, L. Goedeke, 2021, Nature Communications.

Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation

D. Russell, J. Cyster, J. McDonald, 2017, Cell.

Epstein‐Barr Virus‐induced Gene 2 Mediates Allergen‐induced Leukocyte Migration into Airways

N. Jarjour, E. A. Kelly, J. McDonald, 2017, American journal of respiratory and critical care medicine.

Intracellular lipid surveillance by small G protein geranylgeranylation

Peter M. Douglas, J. McDonald, Peter M Douglas, 2022, Nature.

Decreased 11β‐hydroxysteroid dehydrogenase 1 in lungs of steroid receptor coactivator (Src)‐1/‐2 double‐deficient fetal mice is caused by impaired glucocorticoid and cytokine signaling

J. McDonald, Jingfei Chen, C. Mendelson, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma[S]

D. Russell, J. McDonald, David W. Russell, 2012, Journal of Lipid Research.

Lipidomics technologies at the end of the first decade and the beginning of the next.

E. Dennis, E. Fahy, J. McDonald, 2013, Advances in nutrition.

Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex steroid hormone synthesis

J. McDonald, Bonne M. Thompson, C. Zouboulis, 2021, Proceedings of the National Academy of Sciences.

A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection

J. McDonald, D. Heisler, N. Alto, 2022, bioRxiv.

Loss of heat shock factor initiates intracellular lipid surveillance by actin destabilization

Peter M. Douglas, J. McDonald, Sonja L B Arneaud, 2022, Cell reports.

A megaprotein-based molecular bridge critical for lipid trafficking and cold resilience

M. Bassik, Chao Zhang, J. McDonald, 2022, bioRxiv.

Lipidomics reveals a remarkable diversity of lipids in human plasma1[S]

Eoin Fahy, Samuel Kelly, Shankar Subramaniam, 2010, Journal of Lipid Research.

FAF1 blocks ferroptosis by inhibiting peroxidation of polyunsaturated fatty acids

Glenn E. Simmons, J. McDonald, Jin Ye, 2021, Proceedings of the National Academy of Sciences of the United States of America.

Steroid Profiling by Gas Chromatography–Mass Spectrometry and High Performance Liquid Chromatography–Mass Spectrometry for Adrenal Diseases

S. Matthew, J. McDonald, R. Auchus, 2011, Hormones & cancer.

Targeted Determination of Tissue Energy Status by LC-MS/MS

J. McDonald, S. Burgess, S. Deja, 2019, Analytical chemistry.

CLSTN3B enhances lipid droplet function via endoplasmic reticulum contacts

J. McDonald, G. Vale, Kaitlyn M. Eckert, 2022 .

Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels

D. Russell, J. McDonald, Bonne M. Thompson, 2014, Proceedings of the National Academy of Sciences.

25-Hydroxycholesterol suppresses interleukin-1–driven inflammation downstream of type I interferon

D. Russell, J. Cyster, J. McDonald, 2014, Science.

Assessing the Safety of Transarterial Locoregional Delivery of Low-Density Lipoprotein Docosahexaenoic Acid Nanoparticles to the Rat Liver.

Diana C. Canseco, P. Sutphin, J. McDonald, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

An implanted port-catheter system for repeated hepatic arterial infusion of low-density lipoprotein-docosahexaenoic acid nanoparticles in normal rats: A safety study.

J. McDonald, I. Corbin, Junjie Li, 2020, Toxicology and applied pharmacology.

Repeated trans-arterial treatments of LDL-DHA nanoparticles induce multiple pathways of tumor cell death in hepatocellular carcinoma bearing rats

J. McDonald, I. Corbin, Junjie Li, 2022, Frontiers in Oncology.

A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience

M. Bassik, Chao Zhang, J. McDonald, 2022, Nature Communications.

Author Correction: Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer

J. Minna, I. Wistuba, K. Politi, 2022, Nature communications.

Synthesis of thioamides from aldonitrones utilizing thiocarbonyl transfer reagents

D. N. Harpp, J. McDonald, 1983 .

Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.

R. Deberardinis, R. Bachoo, J. McDonald, 2009, Cancer research.

Volatilization of toxaphene from Lakes Michigan and Superior.

D. Swackhamer, J. McDonald, R. Hites, 2001, Environmental science & technology.

Three-phase liquid extraction: a simple and fast method for lipidomic workflows[S]

J. McDonald, Bonne M. Thompson, Matthew A. Mitsche, 2019, Journal of Lipid Research.

Low-density lipoprotein docosahexaenoic acid nanoparticles induce ferroptotic cell death in hepatocellular carcinoma.

Xiaoshun He, Weijun Ou, J. McDonald, 2017, Free radical biology & medicine.

Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry.

D. Russell, J. McDonald, Bonne M. Thompson, 2007, Methods in enzymology.

Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition

J. McDonald, Bonne M. Thompson, Jiawei Wang, 2019, Nature Communications.

Target identification reveals lanosterol synthase as a vulnerability in glioma

B. Garcia, C. Allis, Yupu Liang, 2019, Proceedings of the National Academy of Sciences.

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

Andrew C. Li, C. Glass, S. Subramaniam, 2012, Cell.

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity.

C. Glass, F. Geissmann, Zhengyu Ouyang, 2019, Immunity.

Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition

J. McDonald, Bonne M. Thompson, Jiawei Wang, 2019, Nature Communications.

Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis.

R. Deberardinis, J. Minna, I. Wistuba, 2016, Cell reports.

Neurotransmission- and cellular stress-related gene expression associated with prepulse inhibition in mice.

Y. Hakak, J. McDonald, A. Grottick, 2005, Brain research. Molecular brain research.

27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy.

S. Morrison, J. McDonald, P. Shaul, 2017, The Journal of clinical investigation.

A Mouse Macrophage Lipidome*♦

Eoin Fahy, Edward A. Dennis, Alfred H. Merrill, 2010, The Journal of Biological Chemistry.

Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis

E. Ikonen, Y. Suárez, C. Fernández-Hernando, 2021, Proceedings of the National Academy of Sciences.

Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production.

J. McDonald, L. Parada, K. Abdullah, 2023, Cell chemical biology.

25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production

D. Russell, J. McDonald, Bonne M. Thompson, 2009, Proceedings of the National Academy of Sciences.

A suppressor screen in Mecp 2 mutant mice implicates cholesterol metabolism in Rett syndrome

Christie M. Buchovecky, J. Shendure, M. Justice, 2013 .

A suppressor screen in mouse Mecp2 implicates cholesterol metabolism in Rett Syndrome

Christie M. Buchovecky, J. Shendure, M. Justice, 2013, Nature Genetics.

Snx14 proximity labeling reveals a role in saturated fatty acid metabolism and ER homeostasis defective in SCAR20 disease

J. McDonald, H. Hariri, Jade Bowerman, 2020, Proceedings of the National Academy of Sciences.

Proximity labeling of Snx14 reveals a functional interaction with delta-9 desaturase SCD1 to maintain ER homeostasis

J. McDonald, H. Hariri, Jade Bowerman, 2020 .

Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer

J. Minna, I. Wistuba, K. Politi, 2021, Nature Communications.

Cilia-Associated Oxysterols Activate Smoothened.

D. Elnatan, A. Renslo, P. Beachy, 2018, Molecular cell.

Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI.

R. Deberardinis, J. Cadeddu, R. Lenkinski, 2017, JCI insight.

Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone

C. Tamminga, E. Brown, J. McDonald, 2022, Translational Psychiatry.

Association of Vaginal Progesterone Treatment With Prevention of Recurrent Preterm Birth

J. McDonald, C. Spong, D. McIntire, 2022, JAMA network open.

Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats

Jonathan C. Cohen, H. Hobbs, S. Martin, 2021, Cellular and molecular gastroenterology and hepatology.

A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins.

Nikhil Madhusudhan, J. McDonald, Bonne M. Thompson, 2020, Journal of the American Chemical Society.

Identification and quantitation of sorbitol-based nuclear clarifying agents extracted from common laboratory and consumer plasticware made of polypropylene.

J. McDonald, Bonne M. Thompson, R. Barkley, 2008, Analytical chemistry.

Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol

J. McDonald, Bonne M. Thompson, N. Alto, 2020, Nature Microbiology.

Editorial: 25‐Hydroxycholesterol: a new life in immunology

J. McDonald, David W. Russell, 2010, Journal of leukocyte biology.

Cholesterol-25-hydroxylase promotes efferocytosis and resolution of lung inflammation.

M. Wurfel, W. Janssen, E. Abraham, 2020, JCI insight.

ZMYND8 is a master regulator of 27-hydroxycholesterol that promotes tumorigenicity of breast cancer stem cells

Maohui Luo, J. McDonald, E. Nelson, 2022, Science advances.

25-Hydroxycholesterol Activates the Integrated Stress Response to Reprogram Transcription and Translation in Macrophages*

C. Glass, S. Subramaniam, M. Maurya, 2013, The Journal of Biological Chemistry.

27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth.

L. Girard, Hao Tang, Yang Xie, 2013, Cell reports.

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

C. Siebold, J. McDonald, R. Rohatgi, 2019, eLife.

Cholesterol accessibility at the ciliary membrane controls

C. Siebold, J. McDonald, R. Rohatgi, 2022 .

Approaches to Lipid Analysis

H. Brown, P. Ivanova, J. McDonald, 2016 .

Bazedoxifene and conjugated estrogen prevent diet-induced obesity, hepatic steatosis, and type 2 diabetes in mice without impacting the reproductive tract.

J. McDonald, Bonne M. Thompson, C. Mineo, 2014, American journal of physiology. Endocrinology and metabolism.

Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency

J. McDonald, F. Plattner, Gang Yu, 2017, Cell reports.

Endocannabinoids Inhibit the Induction of Virulence in Enteric Pathogens

V. Sperandio, J. McDonald, A. Pacheco, 2020, Cell.

GPR183-Oxysterol Axis in Spinal Cord Contributes to Neuropathic Pain

J. McDonald, Bonne M. Thompson, G. Kolar, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol

J. McDonald, Bonne M. Thompson, N. Alto, 2020, Nature Microbiology.

Cholesterol accessibility at the ciliary membrane controls 1 Hedgehog signaling 2 3

C. Siebold, J. McDonald, R. Rohatgi, 2019 .

Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion Remodeling

D. Gómez-Coronado, Y. Suárez, C. Fernández-Hernando, 2022, Circulation.

Introducing the Lipidomics Minimal Reporting Checklist

John A. Bowden, Christer S. Ejsing, A. Shevchenko, 2022, Nature Metabolism.

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages

Matthew S. Tremblay, C. Glass, N. Spann, 2018, Proceedings of the National Academy of Sciences.

Drosophila Snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytes

J. McDonald, Steve Jean, B. Collins, 2019, bioRxiv.

Radial dilution model for the distribution of toxaphene in the United States and Canada on the basis of measured concentrations in tree bark.

J. McDonald, R. Hites, 2003, Environmental science & technology.

Transcriptional Integration of Distinct Microbial and Nutritional Signals by the Small Intestinal Epithelium

J. M. Davison, J. McDonald, J. Rawls, 2021, bioRxiv.

Interplay between Asters/GRAMD1s and phosphatidylserine in intermembrane transport of LDL cholesterol

J. McDonald, J. Goldstein, Michael S. Brown, 2022, Proceedings of the National Academy of Sciences.

Myocardial steatosis impairs left ventricular diastolic–systolic coupling in healthy humans

K. Moreau, M. Haykowsky, J. McDonald, 2023, The Journal of physiology.

Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression

J. McDonald, A. Asaithamby, P. Shaul, 2020, Nature Metabolism.

A megaprotein brake for aging and insulin-mTOR signaling

J. McDonald, Dengke K. Ma, Bingying Wang, 2023, bioRxiv.

Insulin-mTOR hyperfunction drives C. elegans aging opposed by the megaprotein LPD-3.

J. McDonald, Dengke K. Ma, Bingying Wang, 2023, bioRxiv : the preprint server for biology.

25-Hydroxycholesterol exacerbates vascular leak during acute lung injury

M. Wurfel, P. Rai, J. Madenspacher, 2023, JCI insight.

Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate

J. McDonald, Hongtu Zhao, Xiaochun Li, 2023, Cell.

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi

J. McDonald, Bonne M. Thompson, Xiaochun Li, 2019, Nature.

17‐alpha Hydroxyprogesterone caproate did not reduce the rate of recurrent preterm birth in a prospective cohort study

D. Nelson, J. McDonald, K. Leveno, 2017, American journal of obstetrics and gynecology.

Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress

J. Liou, J. McDonald, K. Orth, 2019, bioRxiv.

Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases

Carlos L. Arteaga, R. Deberardinis, Srinivas Malladi, 2023, Nature Cancer.

Author response: Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

C. Siebold, J. McDonald, R. Rohatgi, 2019 .

Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice

K. Moore, E. Fisher, Liqian Ma, 2023, Nature communications.

LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans

J. McDonald, Dengke K. Ma, Bingying Wang, 2023, bioRxiv.

Author response: Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice

R. Hammer, J. McDonald, J. Horton, 2017 .