H. Maegawa

T. Uzu, H. Maegawa, K. Isshiki, 2014, Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.

Nutrition and Periodontal Health in the Patients with Diabetes Mellitus: a Review from the Viewpoint of Endothelial Function

K. Morino, H. Maegawa, K. Kondo, 2021, Current Oral Health Reports.

A cross-sectional association of obesity with coronary calcium among Japanese, Koreans, Japanese Americans, and U.S. whites.

L. Kuller, T. Ohkubo, K. Murata, 2013, European heart journal cardiovascular Imaging.

Association of blood levels of marine omega-3 fatty acids with coronary calcification and calcium density in Japanese men

K. Murata, H. Ueshima, H. Maegawa, 2018, European Journal of Clinical Nutrition.

Cholesteryl Ester Transfer Protein, Coronary Calcium and Intima-media Thickness of the Carotid Artery in Middle-Aged Japanese Men

L. Kuller, K. Murata, R. Abbott, 2010 .

Much lower prevalence of coronary calcium detected by electron-beam computed tomography among men aged 40-49 in Japan than in the US, despite a less favorable profile of major risk factors.

L. Kuller, K. Murata, K. Sutton-Tyrrell, 2004, International journal of epidemiology.

High sodium intake is associated with masked hypertension in Japanese patients with type 2 diabetes and treated hypertension.

T. Uzu, H. Maegawa, S. Kume, 2012, American journal of hypertension.

Urinary Potassium Excretion and Renal and Cardiovascular Complications in Patients with Type 2 Diabetes and Normal Renal Function.

H. Arima, T. Uzu, H. Maegawa, 2015, Clinical journal of the American Society of Nephrology : CJASN.

Dapagliflozin as Monotherapy or Combination Therapy in Japanese Patients with Type 2 Diabetes: an Open-Label Study

H. Maegawa, A. Kiyosue, K. Kaku, 2014, Diabetes Therapy.

Association of myeloperoxidase G-463A gene polymorphism with diabetic nephropathy in Japanese type 2 diabetic subjects.

I. Shimomura, H. Kaneto, Y. Yamasaki, 2013, Endocrine journal.

Transcription factor AP-2beta: a negative regulator of IRS-1 gene expression.

K. Morino, H. Maegawa, A. Kashiwagi, 2010, Biochemical and biophysical research communications.

Intronic polymorphisms within TFAP2B regulate transcriptional activity and affect adipocytokine gene expression in differentiated adipocytes.

H. Maegawa, R. Kawamori, A. Kashiwagi, 2006, Molecular endocrinology.

Low Frequency of the Large Insertion in the Human Insulin Gene in Japanese

H. Maegawa, M. Haneda, M. Kobayashi, 1986, Diabetes.

Targeted deletion of Atg5 in intestinal epithelial cells promotes dextran sodium sulfate-induced colitis.

M. Kawahara, H. Maegawa, S. Kume, 2021, Journal of clinical biochemistry and nutrition.

Transcription factor AP-2β inhibits expression and secretion of leptin, an insulin-sensitizing hormone, in 3T3-L1 adipocytes

K. Morino, H. Maegawa, A. Kashiwagi, 2010, International Journal of Obesity.

Transcription Factor Activating Enhancer-binding Protein-2β

H. Maegawa, A. Kashiwagi, S. Maeda, 2006, Journal of Biological Chemistry.

Combination of disease duration‐to‐age at diagnosis and hemoglobin A1c‐to‐serum C‐peptide reactivity ratios predicts patient response to glucose‐lowering medication in type 2 diabetes: A retrospective cohort study across Japan (JDDM59)

H. Maegawa, A. Kanatsuka, Yasunori Sato, 2021, Journal of diabetes investigation.

Element cis regulant la transcription, facteur regulateur de transcription se liant specifiquement a celui-ci et utilisation correspondante

H. Maegawa, Y. Nishio, Atsunori Kashiwagi, 2004 .

A Real-World Observational Study Evaluating the Probability of Glycemic Control with Basal Insulin or Glucagon-Like Peptide-1 Receptor Agonist in Japanese Patients with Type 2 Diabetes

H. Maegawa, M. Baxter, Y. Morimoto, 2020, Diabetes Therapy.

Focal Segmental Glomerular Sclerosis Ameliorated by Long-term Hemodialysis Therapy with Low-density Lipoprotein Apheresis.

T. Uzu, H. Maegawa, S. Kume, 2015, Internal medicine.

Inactivation of TNF-α ameliorates diabetic neuropathy in mice.

H. Kimura, H. Maegawa, L. Chan, 2011, American journal of physiology. Endocrinology and metabolism.

Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis.

T. Uzu, H. Maegawa, S. Kume, 2011, Kidney international.

Oleate and eicosapentaenoic acid attenuate palmitate-induced inflammation and apoptosis in renal proximal tubular cell.

T. Uzu, H. Maegawa, S. Kume, 2010, Biochemical and biophysical research communications.

Endothelium-specific activation of NAD(P)H oxidase in aortas of exogenously hyperinsulinemic rats.

H. Maegawa, M. Haneda, A. Kashiwagi, 1999, The American journal of physiology.

Insulin signaling and its regulation of system A amino acid uptake in cultured rat vascular smooth muscle cells.

H. Maegawa, A. Kashiwagi, T. Obata, 1996, Circulation research.

Fiber-rich diet with brown rice improves endothelial function in type 2 diabetes mellitus: A randomized controlled trial

H. Arima, K. Morino, K. Nemoto, 2017, PloS one.

The associations of C-reactive protein with serum levels of polyunsaturated fatty acids and trans fatty acids among middle-aged men from three populations

L. Kuller, T. Seto, H. Ueshima, 2015, The journal of nutrition, health & aging.

The associations of C-reactive protein with serum levels of polyunsaturated fatty acids and trans fatty acids among middle-aged men from three populations

L. Kuller, T. Seto, H. Ueshima, 2016, The journal of nutrition, health & aging.

Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification Beyond Metabolic Syndrome Components: Shiga Epidemiological Study of Subclinical Atherosclerosis

M. Horie, H. Arima, H. Ueshima, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Diet high in lipid hydroperoxide by vitamin E deficiency induces insulin resistance and impaired insulin secretion in normal rats.

M. Fujimiya, M. Kudo, H. Maegawa, 2005, Diabetes research and clinical practice.

A new antidiabetic agent (JTT-501) rapidly stimulates glucose disposal rates by enhancing insulin signal transduction in skeletal muscle

K. Morino, H. Maegawa, M. Haneda, 1999, Diabetologia.

Long-term in vitro effects of insulin on insulin binding and glucose transport.

H. Maegawa, M. Kobayashi, Y. Takata, 1986, Diabetes research and clinical practice.

CHANGES IN RECEPTOR BINDING, BIOLOGICAL ACTIVITY AND IMMUNOREACTIVITY OF INSULIN CAUSED BY REPLACING THE RESIDUES B23-B26 VVITH ALANINE

H. Maegawa, Masashi Kobayashi, Y. Shigeta, 1984 .

Improved glucose metabolism by Eragrostis tef potentially through beige adipocyte formation and attenuating adipose tissue inflammation

K. Morino, T. Imamura, H. Maegawa, 2018, PloS one.

Fructose induces tubulointerstitial injury in the kidney of mice.

T. Uzu, H. Maegawa, S. Kume, 2012, Biochemical and biophysical research communications.

Insulin production in a neuroectodermal tumor that expresses islet factor-1, but not pancreatic-duodenal homeobox 1.

R. Arai, M. Fujimiya, N. Wong, 2001, The Journal of clinical endocrinology and metabolism.

Dissection of the growth versus metabolic effects of insulin and insulin-like growth factor-I in transfected cells expressing kinase-defective human insulin receptors.

J. Olefsky, H. Maegawa, D. McClain, 1990, The Journal of biological chemistry.

Role of angiotensin II-mediated AMPK inactivation on obesity-related salt-sensitive hypertension.

A. Nishiyama, T. Uzu, H. Maegawa, 2012, Biochemical and biophysical research communications.

Short-term low-dosage pioglitazone treatment improves vascular dysfunction in patients with type 2 diabetes.

T. Uzu, H. Maegawa, A. Kashiwagi, 2007, Endocrine journal.

Higher levels of adiponectin in American than in Japanese men despite obesity.

L. Kuller, H. Ueshima, Y. Kita, 2006, Metabolism: clinical and experimental.

Efficacy and safety of pemafibrate in people with type 2 diabetes and elevated triglyceride levels: 52‐week data from the PROVIDE study

S. Yamashita, H. Maegawa, J. Satoh, 2019, Diabetes, obesity & metabolism.

Ezetimibe prevents hepatic steatosis induced by a high-fat but not a high-fructose diet.

K. Morino, H. Maegawa, S. Kume, 2013, American journal of physiology. Endocrinology and metabolism.

Increased expression of CCAAT/enhancer binding protein-beta and -delta and monocyte chemoattractant protein-1 genes in aortas from hyperinsulinaemic rats.

H. Maegawa, A. Kashiwagi, Y. Nagai, 2007, Diabetologia.

Amla Enhances Mitochondrial Spare Respiratory Capacity by Increasing Mitochondrial Biogenesis and Antioxidant Systems in a Murine Skeletal Muscle Cell Line

K. Morino, H. Maegawa, Hirotaka Yamamoto, 2016, Oxidative medicine and cellular longevity.

The Prognosis of Patients With Type 2 Diabetes and Nonalbuminuric Diabetic Kidney Disease Is Not Always Poor: Implication of the Effects of Coexisting Macrovascular Complications (JDDM 54)

H. Yokoyama, H. Maegawa, K. Yamazaki, 2020, Diabetes Care.

Efficacy and tolerability of vildagliptin in type 2 diabetic patients on hemodialysis

T. Uzu, H. Maegawa, S. Kume, 2011, Journal of diabetes investigation.

Expression of a Dominant Negative SHP-2 in Transgenic Mice Induces Insulin Resistance*

K. Morino, H. Maegawa, M. Haneda, 1999, The Journal of Biological Chemistry.

Eighteen-year trends in the management of patients with diabetes in the Shiga Diabetes Clinical Survey: overall trends and differences by age group

H. Ueshima, H. Maegawa, N. Takashima, 2022, Diabetology International.

Roles of mTOR in Diabetic Kidney Disease

H. Maegawa, S. Kume, M. Yasuda‐Yamahara, 2021, Antioxidants.

Reduction of insulin-stimulated glucose uptake by peroxynitrite is concurrent with tyrosine nitration of insulin receptor substrate-1.

K. Murayama, H. Maegawa, R. Kawamori, 2004, Biochemical and biophysical research communications.

Stem cell factor‐activated bone marrow ameliorates amyotrophic lateral sclerosis by promoting protective microglial migration

H. Maegawa, L. Chan, Hideto Kojima, 2014, Journal of neuroscience research.

Effect of acute exercise on insulin binding to erythrocytes in type II diabetes.

H. Maegawa, M. Kobayashi, Y. Shigeta, 1982, Endocrinologia japonica.

Effect of duration of diabetic state on insulin action in isolated rat soleus muscles.

H. Maegawa, M. Kobayashi, Y. Takata, 1986, Metabolism: clinical and experimental.

A new potentiator of insulin action

H. Maegawa, M. Kobayashi, Y. Shigeta, 1983, FEBS letters.

INSULIN BINDING AND GLUCOSE UPTAKE IN ISOLATED SOLEUS MUSCLES IN SPONTANEOUSLY NON-OBESE DIABETIC MICE

H. Maegawa, Masashi Kobayashi, Y. Shigeta, 1983 .

Association between Obesity and Intake of Different Food Groups among Japanese with Type 2 Diabetes Mellitus—Japan Diabetes Clinical Data Management Study (JDDM68)

Mariko Hatta, Yasunaga Takeda, C. Horikawa, 2022, Nutrients.

Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction.

S. Shoelson, J. Olefsky, P. Roller, 1994, The Journal of biological chemistry.

Trends in glycemic control in patients with insulin therapy compared with non-insulin or no drugs in type 2 diabetes in Japan: a long-term view of real-world treatment between 2002 and 2018 (JDDM 66)

H. Yokoyama, H. Maegawa, K. Yamazaki, 2022, BMJ Open Diabetes Research & Care.

Safety and efficacy of ipragliflozin in Japanese patients with type 2 diabetes in real-world clinical practice: interim results of the STELLA-LONG TERM post-marketing surveillance study

H. Maegawa, K. Tobe, I. Nakamura, 2018, Expert opinion on pharmacotherapy.

Effect of age and sex on insulin binding to human erythrocytes.

H. Maegawa, M. Kobayashi, Y. Shigeta, 1981, Endocrinologia japonica.

Effect of nutritional counseling and long term isomaltulose based liquid formula (MHN-01) intake on metabolic syndrome

H. Maegawa, H. Yamanaka-Okumura, E. Takeda, 2015, Journal of clinical biochemistry and nutrition.

Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation

T. Uzu, H. Maegawa, S. Kume, 2016, Scientific Reports.

A primary defect in insulin receptor in a young male patient with insulin resistance.

H. Maegawa, M. Kobayashi, Y. Takata, 1986, Metabolism: clinical and experimental.

Mechanism for differential effect of protein-tyrosine phosphatase 1B on Akt versus mitogen-activated protein kinase in 3T3-L1 adipocytes.

H. Maegawa, A. Kashiwagi, K. Egawa, 2002, Endocrinology.

Octreotide improves early dumping syndrome potentially through incretins: a case report.

K. Morino, H. Maegawa, K. Ikeda, 2013, Endocrine journal.

Glucagon-Like Peptide-1 Receptor Agonist Utilization in Type 2 Diabetes in Japan: A Retrospective Database Analysis (JDDM 57)

H. Maegawa, T. Aranishi, T. Imaoka, 2020, Diabetes Therapy.

High glucose condition desensitizes insulin action at the levels of receptor kinase.

H. Maegawa, A. Kashiwagi, R. Kikkawa, 1995, Endocrine journal.

Effect of sleeve gastrectomy on body weight, food intake, glucose tolerance, and metabolic hormone level in two different rat models: Goto-Kakizaki and diet-induced obese rat.

H. Maegawa, T. Tani, S. Ugi, 2013, The Journal of surgical research.

Protein O-GlcNAcylation Is Essential for the Maintenance of Renal Energy Homeostasis and Function via Lipolysis during Fasting and Diabetes.

H. Maegawa, S. Kume, M. Chin‐Kanasaki, 2019, Journal of the American Society of Nephrology : JASN.

Baseline characteristics and interim (3-month) efficacy and safety data from STELLA-LONG TERM, a long-term post-marketing surveillance study of ipragliflozin in Japanese patients with type 2 diabetes in real-world clinical practice

H. Maegawa, K. Tobe, I. Nakamura, 2016, Expert opinion on pharmacotherapy.

Inhibition of down regulation by chloroquine in cultured lymphocytes (RPMI-1788 line).

H. Maegawa, M. Kobayashi, Y. Takata, 1985, Diabetes research and clinical practice.

Improvement in Decline Rate of Estimated Glomerular Filtration Rate after Febuxostat Treatment in a Fabry Disease Patient with Enzyme Replacement Therapy-resistant Proteinuria

S. Ohno, H. Maegawa, S. Kume, 2022, Internal medicine.

GW501516, a PPARδ Agonist, Ameliorates Tubulointerstitial Inflammation in Proteinuric Kidney Disease via Inhibition of TAK1-NFκB Pathway in Mice

T. Uzu, T. Sugaya, H. Maegawa, 2011, PloS one.

Transcription factor activating protein-2beta: a positive regulator of monocyte chemoattractant protein-1 gene expression.

K. Morino, H. Maegawa, A. Kashiwagi, 2009, Endocrinology.

Insulin receptors with defective tyrosine kinase inhibit normal receptor function at the level of substrate phosphorylation.

A. Ullrich, J. Olefsky, H. Maegawa, 1988, The Journal of biological chemistry.

Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects.

A. Ullrich, T. Dull, J. Olefsky, 1988, The Journal of biological chemistry.

Definitive diagnosis of mandibular hypoplasia, deafness, progeroid features and lipodystrophy (MDPL) syndrome caused by a recurrent de novo mutation in the POLD1 gene.

H. Maegawa, A. Kashiwagi, T. Kaname, 2018, Endocrine journal.

A new era of diabetic kidney disease treatment with sodium–glucose cotransporter‐2 inhibitors

H. Maegawa, S. Kume, 2022, Journal of diabetes investigation.

Safety and effectiveness of ipragliflozin in Japanese patients with type 2 diabetes mellitus and impaired renal function: subgroup analysis of a 3-year post-marketing surveillance study (STELLA-LONG TERM)

H. Maegawa, K. Tobe, I. Nakamura, 2020, Diabetology International.

Effect of ipragliflozin on liver function in Japanese type 2 diabetes mellitus patients: a subgroup analysis of the STELLA-LONG TERM study (3-month interim results).

H. Maegawa, K. Tobe, I. Nakamura, 2019, Endocrine journal.

SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene.

K. Morino, H. Maegawa, A. Kashiwagi, 2009, BMB reports.

SAFB 1 , an RBMX-binding protein , is a newly identified regulator of hepatic SREBP-1 c gene

K. Morino, H. Maegawa, A. Kashiwagi, 2009 .

Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus

Yusuke Nakamura, Tatsuhiko Tsunoda, Masafumi Matsuda, 2005, Journal of Human Genetics.

Laparoscopic sleeve gastrectomy leads to rapid improvement of glucose tolerance and insulin secretion with enhanced glucagon-like peptide (GLP-1) secretion

H. Maegawa, A. Kashiwagi, K. Ikeda, 2010 .

4-Hydroxy hexenal derived from dietary n-3 polyunsaturated fatty acids induces anti-oxidative enzyme heme oxygenase-1 in multiple organs.

K. Morino, K. Nemoto, H. Maegawa, 2014, Biochemical and biophysical research communications.

The Influence of a Single Nucleotide Polymorphism within CNDP1 on Susceptibility to Diabetic Nephropathy in Japanese Women with Type 2 Diabetes

T. Uzu, H. Maegawa, S. Araki, 2013, PloS one.

Pioglitazone ameliorates high glucose induced desensitization of insulin receptor kinase in Rat 1 fibroblasts in culture.

H. Maegawa, A. Kashiwagi, R. Kikkawa, 1993, Biochemical and biophysical research communications.

Ketone body 3-hydroxybutyrate enhances adipocyte function

I. Shimomura, H. Maegawa, S. Kume, 2022, Scientific Reports.

Insulin-induced c-Jun N-terminal kinase activation is negatively regulated by protein kinase C delta.

K. Morino, H. Maegawa, A. Kashiwagi, 2001, Endocrinology.

Sumoylation of Pdx1 is associated with its nuclear localization and insulin gene activation.

H. Maegawa, A. Kashiwagi, Y. Nishio, 2003, American journal of physiology. Endocrinology and metabolism.

A simple and sensitive method for glutamine:fructose-6-phosphate amidotransferase assay.

K. Morino, H. Maegawa, Z. Shen, 2004, Journal of biochemical and biophysical methods.

Autophagy: a novel therapeutic target for kidney diseases

T. Uzu, H. Maegawa, S. Kume, 2012, Clinical and Experimental Nephrology.

Safety and Effectiveness of Ipragliflozin in Elderly Versus Non-elderly Japanese Patients with Type 2 Diabetes: Subgroup Analysis of STELLA-LONG TERM

H. Maegawa, K. Tobe, I. Nakamura, 2021, Diabetes Therapy.

Safety and efficacy of ipragliflozin in elderly versus non-elderly Japanese patients with type 2 diabetes mellitus: a subgroup analysis of the STELLA-LONG TERM study

H. Maegawa, K. Tobe, I. Nakamura, 2018, Expert opinion on pharmacotherapy.

SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells.

T. Uzu, T. Sugaya, H. Maegawa, 2011, Free radical biology & medicine.

Opposite regulation of tyrosine-phosphorylation of p130(Cas) by insulin and insulin-like growth factor I.

H. Maegawa, A. Kashiwagi, R. Kikkawa, 1998, Journal of biochemistry.

Ipragliflozin, a SGLT2 Inhibitor, Reduced Body Weight and Fat Mass but Not Muscle Mass in Japanese Type 2 Diabetic Patients Treated with Insulin—A Randomized Clinical Trial

H. Arima, K. Morino, H. Maegawa, 2018, Diabetes.

Safety and Effectiveness of Ipragliflozin for Type 2 Diabetes in Japan: 12-Month Interim Results of the STELLA-LONG TERM Post-Marketing Surveillance Study

H. Maegawa, K. Tobe, I. Nakamura, 2019, Advances in Therapy.

Comparing Associations of Dietary Energy Density and Energy Intake, Macronutrients with Obesity in Patients with Type 2 Diabetes (JDDM 63)

Mariko Hatta, Yasunaga Takeda, C. Horikawa, 2021, Nutrients.

Effect of ipragliflozin on liver function in Japanese type 2 diabetes mellitus patients: subgroup analysis of a 3-year post-marketing surveillance study (STELLA-LONG TERM).

H. Maegawa, K. Tobe, I. Nakamura, 2021, Endocrine journal.

Contrast medium-induced severe thrombocytopenia in patient on maintenance hemodialysis: a case report and literature review

H. Maegawa, S. Kume, M. Chin‐Kanasaki, 2020, CEN Case Reports.

Geometry of Sleeve Gastrectomy Measured by 3D CT Versus Weight Loss: Preliminary Analysis

Y. Tomozawa, K. Morino, H. Maegawa, 2020, World Journal of Surgery.

Interconnection between cardiovascular, renal and metabolic disorders: A narrative review with a focus on Japan

K. Node, T. Murohara, T. Kadowaki, 2022, Diabetes, obesity & metabolism.

Effect of diabetes and prediabetes on the development of disability and mortality among middle‐aged Japanese adults: A 22‐year follow up of NIPPON DATA90

H. Ueshima, H. Maegawa, N. Miyagawa, 2022, Journal of diabetes investigation.

Data set for renal sinus fat volume and visceral adipose tissue volume on computed tomography

T. Ohkubo, N. Nitta, Y. Nagatani, 2016, Data in brief.

Insulin receptor kinase phosphorylates protein tyrosine phosphatase containing Src homology 2 regions and modulates its PTPase activity in vitro.

Y. Hinoda, H. Maegawa, A. Kashiwagi, 1994, Biochemical and biophysical research communications.

Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects

M. Kasuga, K. Nanjo, K. Tokunaga, 2008, Journal of Human Genetics.

Changes in prescription patterns and doses of oral antidiabetic drugs in Japanese patients with type 2 diabetes (JDDM70)

H. Maegawa, K. Yamazaki, M. Takeuchi, 2022, Journal of diabetes investigation.

Supernormal insulin: [D-PheB24]-insulin with increased affinity for insulin receptors.

H. Maegawa, K. Inouye, M. Kobayashi, 1982, Biochemical and biophysical research communications.

Massive pericardial effusion secondary to Hashimoto's disease.

H. Maegawa, T. Sugimoto, A. Kashiwagi, 2007, European journal of internal medicine.

Regulation of ATP-sensitive Potassium Channel Subunit Kir6.2 Expression in Rat Intestinal Insulin-producing Progenitor Cells*

H. Maegawa, A. Kashiwagi, K. Egawa, 2005, Journal of Biological Chemistry.

The ligand binding characteristics of a kinase-defective A/K1018 human insulin receptor expressed in Rat 1 fibroblasts.

J. Olefsky, H. Maegawa, D. McClain, 1990, Biochimica et biophysica acta.

Cilostazol Attenuates Spontaneous Microaggregation of Platelets in Type 2 Diabetic Patients With Insufficient Platelet Response to Aspirin

T. Uzu, H. Maegawa, K. Isshiki, 2013, Diabetes Care.

Receptor-mediated degradation by rat adipocytes: comparison of A-14 with A-19 125I-labelled insulin.

H. Maegawa, M. Kobayashi, Y. Shigeta, 1984, Endocrinologia japonica.

The renoprotective effect of once‐weekly GLP‐1 receptor agonist dulaglutide on progression of nephropathy in Japanese patients with type 2 diabetes and moderate to severe chronic kidney disease (JDDM67)

H. Yokoyama, Y. Kurihara, H. Maegawa, 2022, Journal of diabetes investigation.

Evaluation of the method of insulin binding studies in human erythrocytes.

H. Maegawa, M. Kobayashi, Y. Shigeta, 1980, Endocrinologia japonica.

Concerted regulation of early enterocyte differentiation by insulin-like growth factor I, insulin, and transforming growth factor-beta1.

M. Fujimiya, H. Maegawa, M. Haneda, 1998, Proceedings of the Association of American Physicians.

A case of local delayed-type allergy to zinc-containing insulin as a cause of diabetic ketoacidosis in a patient with type 1 diabetes mellitus undergoing continuous subcutaneous insulin infusion

K. Morino, K. Nemoto, H. Maegawa, 2016, Diabetology International.

Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes.

J. Olefsky, H. Maegawa, A. Kashiwagi, 2000, Endocrinology.

Single nucleotide polymorphism (-468 Gly to A) at the promoter region of SREBP-1c associates with genetic defect of fructose-induced hepatic lipogenesis [corrected].

H. Maegawa, A. Kashiwagi, Y. Nagai, 2004, The Journal of biological chemistry.

RBMX is a novel hepatic transcriptional regulator of SREBP‐1c gene response to high‐fructose diet

H. Maegawa, A. Kashiwagi, T. Takemoto, 2007, FEBS letters.

[A case of Cushing syndrome caused by ACTH producing atypical lung carcinoid tumor].

H. Maegawa, M. Kobayashi, H. Masuzaki, 1992, Nihon Naibunpi Gakkai zasshi.

Renoprotective effect of DPP-4 inhibitors against free fatty acid-bound albumin-induced renal proximal tubular cell injury.

T. Uzu, T. Sugaya, H. Maegawa, 2016, Biochemical and biophysical research communications.

Super viral vector for pinpoint gene transfer by molecular ZIP-code

H. Maegawa, Hideto Kojima, Hiromichi Kawai, 2013 .

Src homology 2 domains of protein tyrosine phosphatase are phosphorylated by insulin receptor kinase and bind to the COOH-terminus of insulin receptors in vitro.

H. Maegawa, A. Kashiwagi, R. Kikkawa, 1993, Biochemical and biophysical research communications.

Receptor binding and biological activity of [SerB24]-insulin, an abnormal mutant insulin.

H. Maegawa, M. Haneda, K. Inouye, 1984, Biochemical and biophysical research communications.

Co-expression of mutant and normal human insulin receptors in COS 7 cells.

H. Maegawa, A. Kashiwagi, K. Egawa, 1993, Biochimica et biophysica acta.

Differential Association of Serum n-3 Polyunsaturated Fatty Acids with Various Cerebrovascular Lesions in Japanese Men

K. Nozaki, H. Arima, K. Morino, 2022, Cerebrovascular Diseases.

Epidermis-dermis junction as a novel location for bone marrow-derived cells to reside in response to ionizing radiation.

J. Udagawa, H. Maegawa, T. Nakagawa, 2015, Biochemical and biophysical research communications.

Protein-tyrosine Phosphatase-1B Negatively Regulates Insulin Signaling in L6 Myocytes and Fao Hepatoma Cells*

K. Morino, H. Maegawa, A. Kashiwagi, 2001, The Journal of Biological Chemistry.

Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus

H. Maegawa, Yasuyuki Nakamura, K. Shibata, 2016, Nutrition and metabolic insights.

Hyperglycemia Induces Skin Barrier Dysfunctions with Impairment of Epidermal Integrity in Non-Wounded Skin of Type 1 Diabetic Mice

J. Udagawa, H. Maegawa, T. Nakagawa, 2016, PloS one.

A high-fiber, low-fat diet improves periodontal disease markers in high-risk subjects: a pilot study.

G. King, K. Morino, H. Maegawa, 2014, Nutrition research.

Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease

A. Kawauchi, R. Nishinakamura, S. Nishio, 2019, Nature Communications.

Protein Phosphatase-2Cα as a Positive Regulator of Insulin Sensitivity through Direct Activation of Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes*

J. Olefsky, T. Imamura, H. Maegawa, 2004, Journal of Biological Chemistry.

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

T. Dull, J. Olefsky, H. Maegawa, 1987, The Journal of biological chemistry.

The onset of diabetes in three out of four sisters: a Japanese family with type 1 diabetes. A case report.

T. Uzu, H. Maegawa, A. Kashiwagi, 2009, Endocrine journal.

Localization of the Insulin-like Growth Factor I Receptor Binding Sites for the SH2 Domain Proteins p85, Syp, and GTPase Activating Protein (*)

J. Olefsky, A. Saltiel, H. Maegawa, 1995, The Journal of Biological Chemistry.

Src homology 2 domains of protein tyrosine phosphatase are associated in vitro with both the insulin receptor and insulin receptor substrate‐1 via different phosphotyrosine motifs

J. Olefsky, H. Maegawa, Atsunori Kashiwagi, 1994, FEBS letters.

Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India

J. Danesh, M. McCarthy, P. Deloukas, 2013, Diabetes.

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

Y. J. Kim, J. Danesh, T. Hansen, 2016, Nature Communications.

Bidirectional regulation of monocyte chemoattractant protein-1 gene at distinct sites of its promoter by nitric oxide in vascular smooth muscle cells.

H. Maegawa, A. Kashiwagi, K. Egawa, 2005, American journal of physiology. Cell physiology.

Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes.

T. Uzu, H. Maegawa, S. Kume, 2014, Biochimica et biophysica acta.

Gene Therapy for Neuropathic Pain through siRNA-IRF5 Gene Delivery with Homing Peptides to Microglia

H. Maegawa, Junko Okano, Hideto Kojima, 2018, Molecular therapy. Nucleic acids.

Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin.

M. Fujimiya, M. Kudo, N. Wong, 2002, Diabetes.

MicroRNA-494-3p inhibits formation of fast oxidative muscle fibres by targeting E1A-binding protein p300 in human-induced pluripotent stem cells

K. Morino, T. Imamura, H. Maegawa, 2021, Scientific Reports.

A mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease.

D. Yanagisawa, I. Tooyama, G. Tamiya, 2014, American journal of human genetics.

O‐linked &bgr;‐N‐acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes

T. Uzu, H. Maegawa, S. Kume, 2017, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy

H. Maegawa, S. Kume, D. Koya, 2013, Archives of pharmacal research.

MicroRNA-494 regulates mitochondrial biogenesis in skeletal muscle through mitochondrial transcription factor A and Forkhead box j3.

K. Morino, H. Maegawa, A. Kashiwagi, 2012, American journal of physiology. Endocrinology and metabolism.

Genome-Wide Association Studies Identify Two Novel Loci Conferring Susceptibility to Diabetic Retinopathy in Japanese Patients with Type 2 Diabetes.

M. Horikoshi, L. Sobrin, A. Takahashi, 2021, Human molecular genetics.

Cholesterol levels of Japanese dyslipidaemic patients with various comorbidities: BioBank Japan

Y. Kamatani, Yusuke Nakamura, K. Matsuda, 2017, Journal of epidemiology.

MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2 in proximal tubular cells.

T. Uzu, T. Sugaya, H. Maegawa, 2016, Kidney international.

Autophagy as a Therapeutic Target in Diabetic Nephropathy

T. Uzu, H. Maegawa, S. Kume, 2011, Experimental diabetes research.

Oral Administration of Tetrahydrobiopterin Prevents Endothelial Dysfunction and Vascular Oxidative Stress in the Aortas of Insulin-Resistant Rats

H. Maegawa, A. Kashiwagi, R. Kikkawa, 2000, Circulation research.

Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes

Yusuke Nakamura, Y. Iwamoto, T. Uzu, 2011, Clinical and Experimental Nephrology.

Altered unfolded protein response is implicated in the age-related exacerbation of proteinuria-induced proximal tubular cell damage.

T. Uzu, H. Maegawa, S. Kume, 2013, The American journal of pathology.

Replication Study for the Association of 9 East Asian GWAS-Derived Loci with Susceptibility to Type 2 Diabetes in a Japanese Population

H. Maegawa, R. Kawamori, H. Watada, 2013, PloS one.

Serum glucose, cholesterol and blood pressure levels in Japanese type 1 and 2 diabetic patients: BioBank Japan

Y. Kamatani, Yusuke Nakamura, K. Matsuda, 2017, Journal of epidemiology.

Single Nucleotide Polymorphism (–468 Gly to Ala) at the Promoter Region of Sterol Regulatory Element-binding Protein-1c Associates with Genetic Defect of Fructose-induced Hepatic Lipogenesis*

H. Maegawa, A. Kashiwagi, Y. Nagai, 2004, Journal of Biological Chemistry.

Ala1048→Asp Mutation in the Kinase Domain of Insulin Receptor Causes Defective Kinase Activity and Insulin Resistance

T. Imamura, H. Maegawa, K. Egawa, 1993, Diabetes.

Transforming growth factor β1 T868C gene polymorphism is associated with cerebral infarction in Japanese patients with type 2 diabetes.

I. Shimomura, H. Kaneto, Y. Yamasaki, 2011, Diabetes research and clinical practice.

Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic β Cells during Fasting and in Type 2 Diabetes

T. Uzu, H. Maegawa, S. Kume, 2016, EBioMedicine.

Oral glucose‐stimulated serum C‐peptide predicts successful switching from insulin therapy to liraglutide monotherapy in Japanese patients with type 2 diabetes and renal impairment

T. Uzu, H. Maegawa, S. Kume, 2013, Journal of diabetes investigation.

The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy

T. Uzu, H. Maegawa, S. Kume, 2013, Journal of diabetes research.

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

Yusuke Nakamura, Tatsuhiko Tsunoda, Philippe Froguel, 2010, Nature Genetics.

Predictors for Mild and Severe Hypoglycemia in Insulin-Treated Japanese Diabetic Patients

K. Morino, K. Nemoto, H. Maegawa, 2015, PloS one.

Autophagy: emerging therapeutic target for diabetic nephropathy.

H. Maegawa, S. Kume, D. Koya, 2014, Seminars in nephrology.

Glycaemia and body weight are regulated by sodium-glucose cotransporter 1 (SGLT1) expression via O-GlcNAcylation in the intestine

K. Morino, H. Maegawa, E. Nishi, 2022, Molecular metabolism.

Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association

J. Chan, W. So, R. Ma, 2009, Journal of Human Genetics.

Pioglitazone treatment and cardiovascular event and death in subjects with type 2 diabetes without established cardiovascular disease (JDDM 36).

K. Sugimoto, H. Yokoyama, H. Maegawa, 2015, Diabetes research and clinical practice.

Protein Phosphatase 2A Negatively Regulates Insulin's Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes

J. Olefsky, T. Imamura, H. Maegawa, 2004, Molecular and Cellular Biology.

Endothelium-specific activation of NAD(P)H oxidase in aortas of exogenously hyperinsulinemic rats.

H. Maegawa, M. Haneda, A. Kashiwagi, 1999, American journal of physiology. Endocrinology and metabolism.

Postprandial activation of protein kinase Cµ regulates the expression of adipocytokines via the transcription factor AP-2β.

K. Morino, H. Maegawa, A. Kashiwagi, 2011, International journal of molecular medicine.

Altered Activities of Transcription Factors and Their Related Gene Expression in Cardiac Tissues of Diabetic Rats

H. Maegawa, K. Horiike, M. Haneda, 1998, Diabetes.

Oxidized lipoproteins found in patients with NIDDM stimulate radical-induced monocyte chemoattractant protein-1 mRNA expression in cultured human endothelial cells

H. Maegawa, A. Kashiwagi, R. Kikkawa, 1997, Diabetologia.

Lysophosphatidylcholine stimulates the expression and production of MCP-1 by human vascular endothelial cells.

H. Maegawa, A. Kashiwagi, Atsunori Kashiwagi, 1996, Metabolism: clinical and experimental.

Role of dietary amino acid balance in diet restriction‐mediated lifespan extension, renoprotection, and muscle weakness in aged mice

H. Maegawa, S. Kume, M. Chin‐Kanasaki, 2018, Aging cell.

Omega-3 polyunsaturated fatty acid has an anti-oxidant effect via the Nrf-2/HO-1 pathway in 3T3-L1 adipocytes.

K. Morino, H. Maegawa, A. Kashiwagi, 2013, Biochemical and biophysical research communications.

Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha.

H. Maegawa, A. Kashiwagi, R. Kikkawa, 2002, American journal of physiology. Endocrinology and metabolism.

Elevated serum levels of interleukin-18 in patients with overt diabetic nephropathy: effects of miglitol

T. Uzu, H. Yokoyama, H. Maegawa, 2011, Clinical and Experimental Nephrology.

Lipotoxicity, Nutrient-Sensing Signals, and Autophagy in Diabetic Nephropathy

H. Maegawa, S. Kume, 2020, JMA journal.

Relationship between Kidney Function and Subclinical Atherosclerosis Progression Evaluated by Coronary Artery Calcification

H. Ueshima, H. Maegawa, A. Kadota, 2021, Journal of atherosclerosis and thrombosis.

Machine Learning Approach to Decision Making for Insulin Initiation in Japanese Patients With Type 2 Diabetes (JDDM 58): Model Development and Validation Study

K. Fujihara, H. Maegawa, H. Sone, 2021, JMIR medical informatics.

Machine Learning Approach to Decision Making for Insulin Initiation in Japanese Patients With Type 2 Diabetes (JDDM 58): Model Development and Validation Study (Preprint)

K. Fujihara, H. Maegawa, H. Sone, 2020 .

Liver fat accumulation assessed by computed tomography is an independent risk factor for diabetes mellitus in a population-based study: SESSA (Shiga Epidemiological Study of Subclinical Atherosclerosis).

K. Morino, H. Ueshima, H. Maegawa, 2020, Diabetes research and clinical practice.

Change in Pericardial Fat Volume and Cardiovascular Risk Factors in a General Population of Japanese Men.

M. Budoff, T. Ohkubo, K. Murata, 2018, Circulation Journal.

Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification.

T. Ohkubo, R. Abbott, M. Horie, 2016, Journal of clinical lipidology.

Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men

K. Nozaki, T. Ohkubo, K. Murata, 2016, Journal of the American Heart Association.

Smoking status is associated with mild cognitive impairment assessed with the mini-mental state examination in Japanese diabetic patients

K. Morino, K. Nemoto, H. Maegawa, 2016, Diabetology International.

Association between attentional function and postural instability in Japanese older patients with diabetes mellitus

K. Morino, K. Nemoto, H. Maegawa, 2016, Diabetology International.

Usefulness of a novel system for measuring glucose area under the curve while screening for glucose intolerance in outpatients†

H. Kaneto, M. Matsuhisa, H. Maegawa, 2013, Journal of diabetes investigation.

Evaluation of a Minimally Invasive System for Measuring Glucose Area under the Curve during Oral Glucose Tolerance Tests: Usefulness of Sweat Monitoring for Precise Measurement

Hiromu Nakajima, Wataru Ogawa, Hiroshi Maegawa, 2013, Journal of diabetes science and technology.

Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population

T. Kadowaki, H. Maegawa, R. Kawamori, 2012, Journal of diabetes investigation.

A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes

M. McCarthy, L. Groop, Y. Kamatani, 2018, PloS one.

Regulation of Mitochondrial Biogenesis by Lipoprotein Lipase in Muscle of Insulin-Resistant Offspring of Parents With Type 2 Diabetes

Hongyu Zhao, R. Eckel, Hong Wang, 2012, Diabetes.

A case of bacterial peritonitis complicated by eosinophilic peritonitis in the peritoneal dialysis induction period

H. Maegawa, S. Kume, S. Araki, 2018 .

Sodium–glucose cotransporter 2 inhibitors represent a paradigm shift in the prevention of heart failure in type 2 diabetes patients

H. Maegawa, S. Araki, A. Kashiwagi, 2020, Journal of diabetes investigation.

Furosemide-associated nephrocalcinosis and renal cysts.

T. Uzu, H. Maegawa, K. Isshiki, 2011, Kidney international.

Association of New Loci Identified in European Genome-Wide Association Studies with Susceptibility to Type 2 Diabetes in the Japanese

Yusuke Nakamura, T. Kadowaki, H. Maegawa, 2011, PloS one.

Serum levels of marine-derived n-3 fatty acids in Icelanders, Japanese, Koreans, and Americans--a descriptive epidemiologic study.

V. Gudnason, L. Kuller, T. Harris, 2012, Prostaglandins, leukotrienes, and essential fatty acids.

Circulating levels of 8 cytokines and marine n-3 fatty acids and indices of obesity in Japanese, white, and Japanese American middle-aged men.

L. Kuller, R. Abbott, K. Sutton-Tyrrell, 2010, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Sex-specific relevance of diabetes to occlusive vascular and other mortality : a collaborative meta-analysis of individual data from 980 793 adults from 68 prospective studies

R. Collins, D. Levy, E. Rimm, 2019 .

Lamp-2 deficiency prevents high-fat diet-induced obese diabetes via enhancing energy expenditure.

T. Uzu, H. Maegawa, S. Kume, 2015, Biochemical and biophysical research communications.

A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.

Yusuke Nakamura, T. Morizono, T. Tsunoda, 2012, Human molecular genetics.

Stearoyl-CoA Desaturase-1 Protects Cells against Lipotoxicity-Mediated Apoptosis in Proximal Tubular Cells

T. Uzu, T. Sugaya, H. Maegawa, 2016, International journal of molecular sciences.

Metabolic and hemodynamic effects of sodium‐dependent glucose cotransporter 2 inhibitors on cardio‐renal protection in the treatment of patients with type 2 diabetes mellitus

H. Maegawa, A. Kashiwagi, 2017, Journal of diabetes investigation.

Evaluation of a Novel Glucose Area Under the Curve (AUC) Monitoring System: Comparison with the AUC by Continuous Glucose Monitoring

K. Morino, H. Maegawa, A. Kashiwagi, 2016, Diabetes & metabolism journal.

Enhanced sodium sensitivity and disturbed circadian rhythm of blood pressure in essential hypertension

T. Uzu, G. Kimura, H. Maegawa, 2006, Journal of hypertension.

Preserving β-cell function is the major determinant of diabetes remission following laparoscopic sleeve gastrectomy in Japanese obese diabetic patients.

K. Morino, H. Maegawa, A. Kashiwagi, 2019, Endocrine journal.

Enhanced Intestinal Motility during Oral Glucose Tolerance Test after Laparoscopic Sleeve Gastrectomy: Preliminary Results Using Cine Magnetic Resonance Imaging

K. Morino, H. Maegawa, T. Tani, 2013, PloS one.

Current status of oral antidiabetic drug prescribing patterns based on the body mass index for Japanese type 2 diabetes mellitus patients and yearly changes in diabetologists' prescribing patterns from 2002 to 2019 (JDDM61)

H. Yokoyama, H. Maegawa, K. Yamazaki, 2021, Journal of diabetes investigation.

Current status of achieving blood pressure target and its clinical correlates in Japanese type 2 diabetes (JDDM45)

H. Yokoyama, Y. Kurihara, H. Maegawa, 2017, Journal of diabetes investigation.

Duality of n-3 Polyunsaturated Fatty Acids on Mcp-1 Expression in Vascular Smooth Muscle: A Potential Role of 4-Hydroxy Hexenal

K. Morino, T. Imamura, H. Maegawa, 2015, Nutrients.

Long chain n-3 polyunsaturated fatty acids and incidence rate of coronary artery calcification in Japanese men in Japan and white men in the USA: population based prospective cohort study

L. Kuller, M. Bertolet, K. Sutton-Tyrrell, 2013, Heart.

Influence of cigarette smoking on coronary artery and aortic calcium among random samples from populations of middle-aged Japanese and Korean men

L. Kuller, K. Sutton-Tyrrell, H. Ueshima, 2012, Journal of Epidemiology & Community Health.

Impact of cigarette smoking on the relationship between body mass index and coronary heart disease: a pooled analysis of 3264 stroke and 2706 CHD events in 378579 individuals in the Asia Pacific region

A. Dobson, M. Woodward, T. Welborn, 2009, BMC Public Health.

Cardio- and reno-protective effects of dipeptidyl peptidase III in diabetic mice

H. Maegawa, S. Kume, H. Ogita, 2021, The Journal of biological chemistry.

Ipragliflozin, a sodium–glucose cotransporter 2 inhibitor, reduces bodyweight and fat mass, but not muscle mass, in Japanese type 2 diabetes patients treated with insulin: A randomized clinical trial

K. Murata, H. Arima, K. Morino, 2019, Journal of diabetes investigation.

Increased expression of CCAAT/enhancer binding protein-β and -δ and monocyte chemoattractant protein-1 genes in aortas from hyperinsulinaemic rats

H. Maegawa, A. Kashiwagi, Atsunori Kashiwagi, 2007, Diabetologia.

Overexpression of acetyl CoA carboxylase β exacerbates podocyte injury in the kidney of streptozotocin-induced diabetic mice.

T. Uzu, H. Maegawa, S. Kume, 2018, Biochemical and biophysical research communications.

Declining trends of diabetic nephropathy, retinopathy and neuropathy with improving diabetes care indicators in Japanese patients with type 2 and type 1 diabetes (JDDM 46)

O. Tomonaga, H. Yokoyama, H. Maegawa, 2018, BMJ Open Diabetes Research & Care.

Emerging role of mammalian autophagy in ketogenesis to overcome starvation

T. Uzu, H. Maegawa, S. Kume, 2016, Autophagy.

Role of Nutrient-Sensing Signals in the Pathogenesis of Diabetic Nephropathy

T. Uzu, H. Maegawa, S. Kume, 2014, BioMed research international.

Total energy expenditure is comparable between patients with and without diabetes mellitus: Clinical Evaluation of Energy Requirements in Patients with Diabetes Mellitus (CLEVER-DM) Study

K. Morino, Shigeho Tanaka, H. Maegawa, 2019, BMJ Open Diabetes Research & Care.

New classification and diagnostic criteria for insulin resistance syndrome

T. Yamauchi, H. Maegawa, H. Katagiri, 2022, Diabetology International.

Cholesteryl ester transfer protein, coronary calcium, and intima-media thickness of the carotid artery in middle-age Japanese men.

L. Kuller, K. Murata, R. Abbott, 2009, The American journal of cardiology.

Comparative Effects of Direct Renin Inhibitor and Angiotensin Receptor Blocker on Albuminuria in Hypertensive Patients with Type 2 Diabetes. A Randomized Controlled Trial

H. Kobori, A. Nishiyama, T. Uzu, 2016, PloS one.

PP.03.25: RELATIONSHIP BETWEEN 24-HOUR BLOOD PRESSURE VARIABILITY AND TARGET ORGAN DAMAGE IN PATIENTS WITH TYPE 2 DIABETES

T. Uzu, H. Maegawa, S. Araki, 2015 .

Increased arterial wall stiffness limits flow volume in the lower extremities in type 2 diabetic patients.

S. Morikawa, T. Inubushi, H. Maegawa, 2001, Diabetes care.

Family Support for Medical Nutritional Therapy and Dietary Intake among Japanese with Type 2 Diabetes (JDDM 56)

Mariko Hatta, Yasunaga Takeda, C. Horikawa, 2020, Nutrients.

Diverse metabolic effects of O-GlcNAcylation in the pancreas but limited effects in insulin-sensitive organs in mice

K. Morino, H. Maegawa, S. Kume, 2017, Diabetologia.

Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population

H. Maegawa, R. Kawamori, H. Watada, 2013, Journal of Human Genetics.

Clinical and laboratory characteristics in the families with diabetes and a mitochondrial tRNA(LEU(UUR)) gene mutation.

H. Maegawa, T. Obata, H. Kojima, 1995, Diabetes research and clinical practice.

Lack of O-GlcNAcylation enhances exercise-dependent glucose utilization potentially through AMP-activated protein kinase activation in skeletal muscle.

K. Morino, H. Maegawa, S. Kume, 2018, Biochemical and biophysical research communications.

Protein-tyrosine Phosphatase 1B as New Activator for Hepatic Lipogenesis via Sterol Regulatory Element-binding Protein-1 Gene Expression*

K. Morino, K. Nemoto, H. Maegawa, 2003, Journal of Biological Chemistry.

Effects of Pemafibrate, a Novel Selective PPARα Modulator, on Lipid and Glucose Metabolism in Patients With Type 2 Diabetes and Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial

S. Yamashita, H. Maegawa, J. Satoh, 2018, Diabetes Care.

Advanced Technology for Gene Delivery with Homing Peptides to Spinal Cord through Systemic Circulation in Mice

H. Maegawa, Junko Okano, Hideto Kojima, 2019, Molecular therapy. Methods & clinical development.

Protein-tyrosine phosphatase 1B associates with insulin receptor and negatively regulates insulin signaling without receptor internalization.

H. Maegawa, A. Kashiwagi, K. Egawa, 2004, Journal of biochemistry.

Renal sinus fat volume on computed tomography in middle-aged patients at risk for cardiovascular disease and its association with coronary artery calcification.

T. Ohkubo, N. Nitta, Y. Nagatani, 2016, Atherosclerosis.

Role of O‐linked N‐acetylglucosamine in the homeostasis of metabolic organs, and its potential links with diabetes and its complications

K. Morino, H. Maegawa, 2020, Journal of diabetes investigation.

Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes

H. Maegawa, R. Kawamori, H. Watada, 2015, PloS one.

Ketone bodies: A double‐edged sword for mammalian life span

H. Maegawa, S. Kume, M. Chin‐Kanasaki, 2023, Aging cell.

Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells.

K. Morino, H. Maegawa, A. Kashiwagi, 2009, Atherosclerosis.

Replication study of the association of rs7578597 in THADA, rs10886471 in GRK5, and rs7403531 in RASGRP1 with susceptibility to type 2 diabetes among a Japanese population

H. Maegawa, R. Kawamori, H. Watada, 2015, Diabetology International.

Emerging role of podocyte autophagy in the progression of diabetic nephropathy

T. Uzu, H. Maegawa, S. Kume, 2015, Autophagy.

Ketogenic essential amino acids replacement diet ameliorated hepatosteatosis with altering autophagy-associated molecules.

H. Maegawa, D. Koya, Y. Noguchi, 2013, Biochimica et biophysica acta.

Impact of Renin-Angiotensin System Inhibition on Microalbuminuria in Type 2 Diabetes: A Post Hoc Analysis of the Shiga Microalbuminuria Reduction Trial (SMART)

T. Uzu, H. Maegawa, A. Kashiwagi, 2008, Hypertension Research.

Population Pharmacokinetics and Therapeutic Efficacy of Febuxostat in Patients with Severe Renal Impairment

T. Uzu, H. Maegawa, D. Hira, 2015, Pharmacology.

Impact of obesity on annual medical expenditures and diabetes care in Japanese patients with type 2 diabetes mellitus

K. Morino, H. Maegawa, S. Kume, 2017, Journal of diabetes investigation.

Clinical inertia in basal insulin-treated patients with type 2 diabetes – Results from a retrospective database study in Japan (JDDM 43)

M. Andersen, H. Maegawa, J. Satoh, 2018, PloS one.

Insulin Activates CCAAT/Enhancer Binding Proteins and Proinflammatory Gene Expression through the Phosphatidylinositol 3-Kinase Pathway in Vascular Smooth Muscle Cells*

H. Maegawa, A. Kashiwagi, K. Egawa, 2002, The Journal of Biological Chemistry.

Secular changes in clinical manifestations of kidney disease among Japanese adults with type 2 diabetes from 1996 to 2014

K. Morino, H. Maegawa, S. Kume, 2019, Journal of diabetes investigation.

Presence and functional role of the rapidly activating delayed rectifier K(+) current in left and right atria of adult mice.

H. Maegawa, W. Ding, H. Matsuura, 2010, European journal of pharmacology.

The transcription factor AP-2beta causes cell enlargement and insulin resistance in 3T3-L1 adipocytes.

Hiroshi Maegawa, Kazuhiro Ikeda, H. Maegawa, 2006, Endocrinology.

Alcohol consumption and coronary artery calcium in middle-aged Japanese men.

L. Kuller, K. Murata, H. Ueshima, 2006, The American journal of cardiology.

Clinical inertia in patients with type 2 diabetes treated with oral antidiabetic drugs: Results from a Japanese cohort study (JDDM53)

M. Andersen, H. Maegawa, Y. Ishigaki, 2020, Journal of diabetes investigation.

High glucose condition activates protein tyrosine phosphatases and deactivates insulin receptor function in insulin-sensitive rat 1 fibroblasts.

H. Maegawa, A. Kashiwagi, R. Kikkawa, 1994, Biochemical and biophysical research communications.

MafA differentiates rat intestinal cells into insulin-producing cells.

M. Kudo, H. Maegawa, A. Kashiwagi, 2006, Biochemical and biophysical research communications.

A Single Nucleotide Polymorphism within DUSP9 Is Associated with Susceptibility to Type 2 Diabetes in a Japanese Population

H. Maegawa, R. Kawamori, H. Watada, 2012, PloS one.

Receptor-binding kinetics of A-14 and A-19 125I-labelled insulin.

H. Maegawa, M. Kobayashi, Y. Shigeta, 1984, Biochimica et biophysica acta.

Validity of the Use of a Triaxial Accelerometer and a Physical Activity Questionnaire for Estimating Total Energy Expenditure and Physical Activity Level among Elderly Patients with Type 2 Diabetes Mellitus: CLEVER-DM Study

K. Morino, Shigeho Tanaka, H. Maegawa, 2020, Annals of Nutrition and Metabolism.

Lipoprotein-associated phospholipase A2 is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population.

T. Ohkubo, M. Horie, Takeshi Kimura, 2016, Atherosclerosis.

Arterial stiffness and renal impairment in non‐proteinuric type 2 diabetic patients

T. Uzu, H. Maegawa, S. Kume, 2011, Journal of diabetes investigation.

Cardiovascular disease management in people with diabetes outside North America and Western Europe in 2006 and 2015

J. Shaw, A. Motala, F. Pirie, 2018, Diabetic medicine : a journal of the British Diabetic Association.

Low Blood Flow Estimates in Lower-Leg Arteries Predict Cardiovascular Events in Japanese Patients With Type 2 Diabetes With Normal Ankle-Brachial Indexes A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

S. Morikawa, T. Inubushi, H. Maegawa, 2006, Diabetes Care.

Abnormal peripheral circulation in type 2 diabetic patients with normal ankle-brachial index associates with coronary atherosclerosis, large artery stiffness, and peripheral vascular resistance.

S. Morikawa, T. Inubushi, H. Maegawa, 2005, Diabetes research and clinical practice.

Activation of metabotropic glutamate receptors is necessary for long-term potentiation in the dentate gyrus and for spatial learning

M. Er̀rington, T. Bliss, H. Maegawa, 1994, Neuropharmacology.

Safety and efficacy of skin patches containing loxoprofen sodium in diabetic patients with overt nephropathy

T. Uzu, H. Maegawa, S. Kume, 2013, Clinical and Experimental Nephrology.

Relationship between the magnitude of body mass index reductions and remission in patients with type 2 diabetes in real world settings: Analysis of nationwide patient registry in Japan (JDDM74)

K. Fujihara, H. Maegawa, H. Sone, 2023, Diabetes, obesity & metabolism.

Incidence and predictors of remission and relapse of type 2 diabetes mellitus in Japan: Analysis of a nationwide patient registry (JDDM73)

K. Fujihara, H. Maegawa, H. Sone, 2023, Diabetes, obesity & metabolism.

MicroRNA-494 plays a role in fiber type-specific skeletal myogenesis in human induced pluripotent stem cells.

K. Morino, T. Imamura, H. Maegawa, 2015, Biochemical and biophysical research communications.

MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-α signalling in beige adipocytes

K. Morino, T. Imamura, H. Maegawa, 2018, Scientific Reports.

Japanese men have larger areas of visceral adipose tissue than Caucasian men in the same levels of waist circumference in a population-based study

L H Kuller, A Sekikawa, L. Kuller, 2012, International Journal of Obesity.

Properties of a human insulin receptor with a COOH-terminal truncation. I. Insulin binding, autophosphorylation, and endocytosis.

A. Ullrich, T. Dull, J. Olefsky, 1988, The Journal of biological chemistry.

SHPTP2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates.

H. Maegawa, A. Kashiwagi, T. Obata, 1996, Biochemical and Biophysical Research Communications - BBRC.

Intima-media thickness of the carotid artery and the distribution of lipoprotein subclasses in men aged 40 to 49 years between whites in the United States and the Japanese in Japan for the ERA JUMP study.

L. Kuller, K. Sutton-Tyrrell, H. Ueshima, 2008, Metabolism: clinical and experimental.

Association between urinary angiotensinogen levels and renal and cardiovascular prognoses in patients with type 2 diabetes mellitus

H. Kobori, T. Uzu, H. Maegawa, 2011, Journal of diabetes investigation.

In vitro effects of glucocorticoid on glucose transport in rat adipocytes: evidence of a post-receptor coupling defect in insulin action.

H. Maegawa, M. Kobayashi, Y. Takata, 1984, Journal of biochemistry.

Annual trends in glycemic control and prescribing patterns in diabetic treatment according to age in Japanese patients with type 2 diabetes between 2012 and 2019 (JDDM XX).

K. Morino, H. Yokoyama, H. Maegawa, 2023, Diabetes research and clinical practice.

Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan.

M. Kasuga, K. Tokunaga, J. Takeda, 2008, The Journal of clinical endocrinology and metabolism.

1H- and 31P-magnetic resonance spectroscopy and imaging as a new diagnostic tool to evaluate neuropathic foot ulcers in Type II diabetic patients

S. Morikawa, T. Inubushi, H. Maegawa, 2000, Diabetologia.

Carotid intima-media thickness and plaque in apparently healthy Japanese individuals with an estimated 10-year absolute risk of CAD death according to the Japan Atherosclerosis Society (JAS) guidelines 2012: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA).

T. Ohkubo, H. Ueshima, T. Kadowaki, 2013, Journal of atherosclerosis and thrombosis.

Replication Study in a Japanese Population of Six Susceptibility Loci for Type 2 Diabetes Originally Identified by a Transethnic Meta-Analysis of Genome-Wide Association Studies

H. Maegawa, R. Kawamori, H. Watada, 2016, PloS one.

Assessing the clinical utility of a genetic risk score constructed using 49 susceptibility alleles for type 2 diabetes in a Japanese population.

T. Tsunoda, H. Maegawa, R. Kawamori, 2013, The Journal of clinical endocrinology and metabolism.

Diabetes management and treatment approaches outside of North America and West Europe in 2006 and 2015

J. Shaw, A. Motala, F. Pirie, 2019, Acta Diabetologica.

A role for bone marrow–derived cells in diabetic nephropathy

Hiroshi Nobuta, H. Maegawa, S. Kume, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Sex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980 793 adults from 68 prospective studies

R. Collins, R. Kronmal, E. Vartiainen, 2018, The lancet. Diabetes & endocrinology.

MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-α signalling in beige adipocytes

K. Morino, T. Imamura, H. Maegawa, 2018, Scientific Reports.

Printed in U.S.A. Copyright © 2000 by The Endocrine Society Persistent Activation of Phosphatidylinositol 3-Kinase Causes Insulin Resistance Due to Accelerated Insulin- Induced Insulin Receptor Substrate-1 Degradation in

J. Olefsky, H. Maegawa, Atsunori Kashiwagi, 2022 .

A family with type A insulin resistance syndrome caused by a novel insulin receptor mutation

H. Maegawa, Y. Hirota, Y. Fujita, 2023, Endocrinology, diabetes & metabolism case reports.

Decreased Biologic Activity and Degradation of Human [SerB24]-Insulin, a Second Mutant Insulin

H. Maegawa, M. Haneda, K. Inouye, 1985, Diabetes.

Predictors for Mild and Severe Hypoglycemia in Insulin-Treated Japanese Diabetic Patients

K. Morino, H. Maegawa, S. Ugi, 2015, PloS one.

Evidence of the lack of receptor-mediated insulin degradation in human cultured lymphocytes (RPMI-1788 line).

H. Maegawa, M. Kobayashi, H. Yasuda, 1983, Endocrinologia japonica.

Effect of L-Dopa Administration on Insulin Binding: Possible Role of Growth Hormone in Regulation of Insulin Receptor Affinity

H. Maegawa, M. Kobayashi, Y. Shigeta, 1982, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Prevalence and major risk factors of reduced flow volume in lower extremities with normal ankle-brachial index in Japanese patients with type 2 diabetes.

Shigehiro Morikawa, Toshiro Inubushi, Hitoshi Yasuda, 2003, Diabetes care.

Insulin-specific activation of S6 kinase and its desensitization in cultured rat vascular smooth muscle cells.

H. Maegawa, A. Kashiwagi, Y. Shigeta, 1995, Atherosclerosis.

beta-Sitosterolemia with generalized eruptive xanthomatosis.

H. Maegawa, A. Kashiwagi, R. Kikkawa, 1997, Endocrine journal.

Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus

H. Kimura, H. Maegawa, A. Kashiwagi, 2013, Nature Communications.

Usefulness of waveform analysis of popliteal artery in Type II diabetic patients using gated magnetic resonance 2D-cine-PC imaging and 31P spectroscopy

S. Morikawa, T. Inubushi, H. Maegawa, 2000, Diabetologia.

Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy

H. Maegawa, S. Kume, D. Koya, 2013, Archives of Pharmacal Research.

Inactivation of TNF-α ameliorates diabetic neuropathy in mice.

H. Kimura, H. Maegawa, L. Chan, 2011, American journal of physiology. Endocrinology and metabolism.

Coexistence of Pheochromocytoma and Primary Aldosteronism due to Multiple Aldosterone-producing Micronodules in the Ipsilateral Adrenal Gland

H. Sasano, H. Maegawa, Y. Fujita, 2023, Internal medicine.

Oleate and eicosapentaenoic acid attenuate palmitate-induced inflammation and apoptosis in renal proximal tubular cell.

T. Uzu, H. Maegawa, S. Kume, 2010, Biochemical and biophysical research communications.

Stiffness and impaired blood flow in lower-leg arteries are associated with severity of coronary artery calcification among asymptomatic type 2 diabetic patients.

S. Morikawa, T. Inubushi, H. Maegawa, 2004, Diabetes care.

Ketogenic essential amino acids replacement diet ameliorated hepatosteatosis with altering autophagy-associated molecules.

H. Maegawa, D. Koya, Y. Noguchi, 2013, Biochimica et biophysica acta.

Efficacy of metformin on postprandial plasma triglyceride concentration by administration timing in patients with type 2 diabetes mellitus: A randomized cross‐over pilot study

K. Morino, H. Maegawa, S. Ugi, 2019, Journal of diabetes investigation.

Nutritional and metabolic control of germ cell fate through O‐GlcNAc regulation

K. Morino, H. Maegawa, Asuka Takehara, 2023, EMBO reports.

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

J. Danesh, O. Pedersen, N. Grarup, 2016, Nature Communications.

Prolonged disappearance rate of a structurally abnormal mutant insulin from the circulation in humans.

H. Maegawa, M. Haneda, M. Kobayashi, 1985, The Journal of clinical endocrinology and metabolism.

Effect of sleeve gastrectomy on body weight, food intake, glucose tolerance, and metabolic hormone level in two different rat models: Goto-Kakizaki and diet-induced obese rat.

H. Maegawa, T. Tani, S. Ugi, 2013, The Journal of surgical research.

Secular changes in clinical manifestations of kidney disease among Japanese adults with type 2 diabetes from 1996 to 2014

K. Morino, H. Maegawa, S. Kume, 2019, Journal of diabetes investigation.