S. Lye

C. Pennell, S. Lye, L. Briollais, 2015, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

Monocyte Chemoattractant Protein-1 (CCL-2) Integrates Mechanical and Endocrine Signals That Mediate Term and Preterm Labor1

S. Lye, O. Shynlova, A. Dorogin, 2008, The Journal of Immunology.

Corticotropin-releasing hormone and proopiomelanocortin-derived peptides are present in human myometrium.

I. Cameron, A. Thompson, S. Lye, 1998, The Journal of clinical endocrinology and metabolism.

Maternal malnutrition impacts placental morphology and transporter expression: an origin for poor offspring growth.

S. Lye, E. Matysiak-Zablocki, M. Kibschull, 2020, The Journal of nutritional biochemistry.

Focal Adhesion Kinase Is a Key Mediator of Human Trophoblast Development

M. Post, S. Lye, I. Caniggia, 2001, Laboratory Investigation.

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGF b 3

M. Gassmann, M. Post, S. Lye, 2018 .

The Raine study had no evidence of significant perinatal selection bias after two decades of follow up: a longitudinal pregnancy cohort study

L. Straker, C. Pennell, P. Eastwood, 2017, BMC Pregnancy and Childbirth.

P-glycoprotein expression and localization in the rat uterus throughout gestation and labor.

S. Lye, O. Shynlova, M. Kibschull, 2016, Reproduction.

Precision Medicine, Developmental Plasticity and Prevention of Non-Communicable Disease

J. Attia, L. Beilin, C. Pennell, 2020 .

Relationship Between Vitamin D Status From Childhood to Early Adulthood With Body Composition in Young Australian Adults

L. Straker, P. Holt, C. Pennell, 2019, Journal of the Endocrine Society.

Strain Differences in the Impact of Dietary Restriction on Fetal Growth and Pregnancy in Mice

C. Pennell, S. Lye, Brian S. Knight, 2007, Reproductive Sciences.

Maternal blood EBF1-based microRNA transcripts as biomarkers for detecting risk of spontaneous preterm birth: a nested case-control study

S. Lye, Guoli Zhou, C. Holzman, 2020, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

ATP-binding cassette transporters in reproduction: a new frontier.

F. Reis, S. Lye, W. Gibb, 2015, Human reproduction update.

CHAPTER 55 – Parturition

S. Lye, J. Challis, W. Gibb, 2006 .

A Standardized Template for Clinical Studies in Preterm Birth

Scott M. Williams, C. Pennell, S. Lye, 2012, Reproductive Sciences.

Analysis of baseline hypothalamic-pituitary-adrenal activity in late adolescence reveals gender specific sensitivity of the stress axis

I. McKeague, J. Foster, E. R. Kloet, 2013, Psychoneuroendocrinology.

Localization of two angiogenic growth factors (PDECGF and VEGF) in human placentae throughout gestation.

S. Lye, E. Carney, M. R. Jackson, 1994, Placenta.

Phosphorylation and partial sequence of pregnant sheep myometrium myosin light chain kinase

S. Lye, M. Pato, E. Kerc, 1995, Molecular and Cellular Biochemistry.

Changes in Structure, Mechanics, and Insulin-Like Growth Factor-Related Gene Expression in the Lungs of Newborn Rats Exposed to Air or 60% Oxygen

Jeffrey F. Young, A. Tanswell, M. Post, 1996, Pediatric Research.

Increase in messenger ribonucleic acid encoding the myometrial gap junction protein, connexin-43, requires protein synthesis and is associated with increased expression of the activator protein-1, c-fos.

S. Lye, M. Piersanti, S. J. Lye, 1995, Endocrinology.

Myometrial transcriptional regulation of the gap junction gene, connexin-43.

S. Lye, X. Bai, D. Lefebvre, 1995, Reproduction, fertility, and development.

Decidual Inflammation Drives Chemokine-Mediated Immune Infiltration Contributing to Term Labor

S. Lye, O. Shynlova, K. A. Adams Waldorf, 2021, The Journal of Immunology.

Gestational age‐dependent gene expression profiling of ATP‐binding cassette transporters in the healthy human placenta

F. Reis, S. Lye, W. Gibb, 2018, Journal of cellular and molecular medicine.

Increased expression of connexin-43 in the rat myometrium during labor is associated with an increase in the plasma estrogen:progesterone ratio.

S. Lye, T. Petrocelli, B. Nicholson, 1993, Endocrinology.

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.

Nicholas J Timpson, Clive Osmond, Mark I McCarthy, 2013, Human molecular genetics.

Progressive expression of trophoblast‐specific genes during formation of mouse trophoblast giant cells in vitro

J. Rossant, S. Lye, E. Carney, 1993, Molecular reproduction and development.

Differential expression of myometrial AP‐1 proteins during gestation and labour

S. Lye, O. Shynlova, E. Matysiak-Zablocki, 2017, Journal of cellular and molecular medicine.

Management of Twin Pregnancies (Part 1)

Joshua R. Smith, L. Keith, D. Young, 2000 .

Reduced placental villous tree elaboration in small-for-gestational-age pregnancies: relationship with umbilical artery Doppler waveforms.

S. Lye, J. Mullen, A. Walsh, 1995, American journal of obstetrics and gynecology.

Maternal blood endotoxin activity in pregnancies complicated by preterm premature rupture of membranes

S. Lye, O. Shynlova, K. Murphy, 2019, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

Food insecurity, diet quality and body composition: data from the Healthy Life Trajectories Initiative (HeLTI) pilot survey in urban Soweto, South Africa

S. Norris, K. Ward, S. Lye, 2021, Public Health Nutrition.

Molecular evidence of functional progesterone withdrawal in human myometrium

S. Lye, O. Shynlova, E. Matysiak-Zablocki, 2016, Nature Communications.

Regulation of Parturition

S. Lye, O. Shynlova, 2014 .

Infiltration of myeloid cells into decidua is a critical early event in the labour cascade and post-partum uterine remodelling

S. Lye, O. Shynlova, Yunqing Li, 2013, Journal of cellular and molecular medicine.

Common variants at 12q15 and 12q24 are associated with infant head circumference

Aad van der Lugt, Xavier Estivill, Sudha Seshadri, 2012, Nature Genetics.

Activation of ovine fetal adrenal function by pulsatile or continuous administration of adrenocorticotropin-(1-24). II. Effects on adrenal cell responses in vitro.

S. Lye, J. Challis, E. Manchester, 1983, Endocrinology.

Differential Expression of Activator Protein-1 Transcription Factors in Pregnant Rat Myometrium1

Jennifer A. Mitchell, S. Lye, 2002, Biology of reproduction.

Dose-Dependent Effects of Meloxicam Administration on Cyclooxygenase-1 and Cyclooxygenase-2 Protein Expression in Intrauterine Tissues and Fetal Tissues of a Sheep Model of Preterm Labor

S. Lye, V. Rac, C. Scott, 2007, Reproductive Sciences.

Meloxicam effectively inhibits preterm labor uterine contractions in a chronically catheterized pregnant sheep model: impact on fetal blood flow and fetal-maternal physiologic parameters.

S. Lye, V. Rac, C. Scott, 2006, American journal of obstetrics and gynecology.

Fetal signals and parturition

Jim F. Johnstone, P. Gluckman, F. Bloomfield, 2005, The journal of obstetrics and gynaecology research.

Expression of breast cancer resistance protein (BCRP/ABCG2) in human placenta throughout gestation and at term before and after labor.

J. Kingdom, S. Lye, D. Baczyk, 2006, Canadian journal of physiology and pharmacology.

Endothelin-1 and O2-Mediated Pulmonary Hypertension in Neonatal Rats: A Role for Products of Lipid Peroxidation

A. Tanswell, H. Frndova, S. Lye, 2000, Pediatric Research.

Expression of SARS-CoV-2 cell entry genes, ACE2 and TMPRSS2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia

S. Lye, Siliang Li, M. Kibschull, 2020, American Journal of Obstetrics and Gynecology.

Preterm Labor Endocrine Signals That Mediate Term and ( CCL2 ) Integrates Mechanical and Monocyte Chemoattractant Protein-1

S. Lye, O. Shynlova, A. Dorogin, 2008 .

Determinants of anaemia among women of reproductive age in South Africa: A Healthy Life Trajectories Initiative (HeLTI)

S. Norris, S. Lye, L. Ware, 2021, PloS one.

Regulation of Connexin43 Expression by c-Fos and c-Jun in Myometrial Cells

Jennifer A. Mitchell, S. Lye, 2001, Cell communication & adhesion.

Genetics and Genomics of Preterm Birth

S. Lye, O. Shynlova, Lubna Nadeem, 2019, Human Reproductive and Prenatal Genetics.

Glucocorticoids modulate multidrug resistance transporters in the first trimester human placenta

S. Lye, W. Gibb, S. Matthews, 2018, Journal of cellular and molecular medicine.

Myometrial Apoptosis: Activation of the Caspase Cascade in the Pregnant Rat Myometrium at Midgestation1

S. Lye, O. Shynlova, A. Dorogin, 2006, Biology of reproduction.

The expression of transforming growth factor beta in pregnant rat myometrium is hormone and stretch dependent.

S. Lye, O. Shynlova, B. L. Langille, 2007, Reproduction.

Effect of the 21-Aminosteroid U74389G on Oxygen-Induced Free Radical Production, Lipid Peroxidation, and Inhibition of Lung Growth in Neonatal Rats

A. Tanswell, S. Lye, R. Belcastro, 1999, Pediatric Research.

15-hydroxyprostaglandin dehydrogenase and cyclooxygenase 2 messenger ribonucleic acid expression and immunohistochemical localization in human cervical tissue during term and preterm labor.

A. Malmström, S. Lye, J. Challis, 2004, The Journal of clinical endocrinology and metabolism.

Insulin-like Growth Factors and Their Binding Proteins Define Specific Phases of Myometrial Differentiation During Pregnancy in the Rat1

S. Lye, O. Shynlova, B. L. Langille, 2007, Biology of reproduction.

Prostaglandins and mechanisms of preterm birth.

S. Lye, D. Sloboda, J. Newnham, 2002, Reproduction.

Changes in Expression of Platelet-Derived Growth Factor and Its Receptors in the Lungs of Newborn Rats Exposed to Air or 60% O2

A. Tanswell, M. Post, S. Lye, 2000, Pediatric Research.

Localization of prostaglandin synthase type-1 (PGHS-1) mRNA and prostaglandin synthase type-2 (PGHS-2) mRNA in ovine myometrium and endometrium throughout gestation.

S. Lye, J. Challis, W. Gibb, 2000, The Journal of endocrinology.

Thromboxane A(2) receptors mediate pulmonary hypertension in 60% oxygen-exposed newborn rats by a cyclooxygenase-independent mechanism.

A. Tanswell, S. Lye, R. Belcastro, 2002, American journal of respiratory and critical care medicine.

Association between maternal acetaminophen use and adverse birth outcomes in a pregnancy and birth cohort

Jennifer D. Brooks, J. Knight, J. Brooks, 2019, Pediatric Research.

Interaction of Pregnancy-Specific Glycoprotein 1 With Integrin α5β1 Is a Modulator of Extravillous Trophoblast Functions

Kenneth M. Yamada, B. Hinz, M. Yáñez-Mó, 2019, Cells.

ACE2 Is Expressed in Immune Cells That Infiltrate the Placenta in Infection-Associated Preterm Birth

S. Lye, S. Matthews, E. Bloise, 2021, Cells.

LOX family enzymes expression in vaginal tissue of premenopausal women with severe pelvic organ prolapse

S. Lye, O. Shynlova, H. Drutz, 2010, International Urogynecology Journal.

Demonstration that progesterone 'blocks' uterine activity in the ewe in vivo by a direct action on the myometrium.

S. Lye, D. G. Porter, 1978, Journal of reproduction and fertility.

Effect of oxygen on multidrug resistance in the first trimester human placenta.

S. Lye, W. Gibb, S. Matthews, 2013, Placenta.

Physiologic Uterine Inflammation and Labor Onset

S. Lye, O. Shynlova, Yu-Hui Lee, 2013, Reproductive Sciences.

Ablation of connexin43 in uterine smooth muscle cells of the mouse causes delayed parturition

K. Willecke, F. Hofmann, R. Feil, 2006, Journal of Cell Science.

Impact of maternal physical activity on fetal breathing and body movement--A review.

S. Lye, G. Wells, D. Sussman, 2016, Early human development.

Effects of cortisol and oestradiol on hepatic 11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor proteins in late-gestation sheep fetus.

S. Lye, N. Alfaidy, J. Challis, 2003, The Journal of endocrinology.

Regulation of c-fos expression by static stretch in rat myometrial smooth muscle cells.

Mingyao Liu, S. Lye, O. Shynlova, 2002, American journal of obstetrics and gynecology.

Spatiotemporal expression of alpha(1), alpha(3) and beta(1) integrin subunits is altered in rat myometrium during pregnancy and labour.

S. Lye, O. Shynlova, S. Williams, 2010, Reproduction, fertility, and development.

Dynamic changes in maternal decidual leukocyte populations from first to second trimester gestation.

S. Lye, S. Keating, Rebecca L. Jones, 2014, Placenta.

Human Leukocyte Antigen HLA-C, HLA-G, HLA-F and HLA-E placental profiles are altered in Early Severe Preeclampsia and Preterm Birth with Chorioamnionitis.

S. Lye, D. Geraghty, L. Myatt, 2022, American journal of obstetrics and gynecology.

Definitive class I human leukocyte antigen expression in gestational placentation: HLA‐F, HLA‐E, HLA‐C, and HLA‐G in extravillous trophoblast invasion on placentation, pregnancy, and parturition

S. Lye, D. Geraghty, C. Dunk, 2017, American journal of reproductive immunology.

HoxA10 and HoxA11 Regulate the Expression of Contraction-Associated Proteins and Contribute to Regionalized Myometrium Phenotypes in Women

S. Lye, Haolong Li, Xuesen Dong, 2018, Reproductive Sciences.

Cytokine Changes in Maternal Peripheral Blood Correlate With Time-to-Delivery in Pregnancies Complicated by Premature Prelabor Rupture of the Membranes

S. Lye, O. Shynlova, K. Murphy, 2018, Reproductive Sciences.

The immune potential of decidua-resident CD16+CD56+ NK cells in human pregnancy.

S. Lye, Jianhong Zhang, 2021, Human immunology.

Local oestrogen therapy modulates extracellular matrix and immune response in the vaginal tissue of post‐menopausal women with severe pelvic organ prolapse

S. Lye, O. Shynlova, M. Alarab, 2019, Journal of cellular and molecular medicine.

Transcriptional Regulation of Human Myometrium and the Onset of Labor

S. Lye, J. Challis, X. Dong, 2005, The Journal of the Society for Gynecologic Investigation: JSGI.

Expression of prostaglandin I(2) synthase, but not prostaglandin E synthase, changes in myometrium of women at term pregnancy.

S. Lye, N. Alfaidy, J. Challis, 2002, The Journal of clinical endocrinology and metabolism.

Differential changes in 15-hydroxyprostaglandin dehydrogenase and prostaglandin H synthase (types I and II) in human pregnant myometrium.

H. Tai, S. Lye, J. Challis, 2002, The Journal of clinical endocrinology and metabolism.

Corticotropin-releasing hormone receptor subtype 1 is significantly up-regulated at the time of labor in the human myometrium.

S. Lye, J. Challis, M. Y. Stevens, 1998, The Journal of clinical endocrinology and metabolism.

Endocrine Gland-Derived Endothelial Growth Factor (EG-VEGF) Is a Potential Novel Regulator of Human Parturition1

S. Lye, J. Guibourdenche, V. Sapin, 2014, Biology of reproduction.

Prostaglandins and Parturition a

S. Lye, J. Challis, W. Gibb, 1997, Annals of the New York Academy of Sciences.

Localization of endoglin, a transforming growth factor-beta binding protein, and of CD44 and integrins in placenta during the first trimester of pregnancy.

S. Lye, M. Letarte, M. Forte, 1994, Biology of reproduction.

Sphingosine signalling regulates decidual NK cell angiogenic phenotype and trophoblast migration.

S. Lye, C. Dunk, Jianhong Zhang, 2013, Human reproduction.

Regulation of transcripts encoding the myometrial gap junction protein, connexin-43, by estrogen and progesterone.

S. Lye, T. Petrocelli, 1993, Endocrinology.

Identification of a Novel Neutrophil Population: Proangiogenic Granulocytes in Second-Trimester Human Decidua

J. Kingdom, S. Lye, B. Croy, 2014, The Journal of Immunology.

Second-Trimester Human Decidua Population: Proangiogenic Granulocytes in Identification of a Novel Neutrophil

S. Lye, B. Croy, Rebecca L. Jones, 2014 .

The Molecular Role of CONNEXIN43 in Human Trophoblast Cell Fusion

S. Lye, S. Drewlo, D. Baczyk, 2012 .

Connexin31-deficient trophoblast stem cells: a model to analyze the role of gap junction communication in mouse placental development.

J. Rossant, S. Lye, E. Winterhager, 2004, Developmental biology.

Gadolinium Chloride Inhibits Pulmonary Macrophage Influx and Prevents O2-Induced Pulmonary Hypertension in the Neonatal Rat

A. Tanswell, M. Post, H. Frndova, 2001, Pediatric Research.

Decidual leucocytes infiltrating human spiral arterioles are rich source of matrix metalloproteinases and degrade extracellular matrix in vitro and in situ

S. Lye, J. Aplin, Rebecca L. Jones, 2018, American journal of reproductive immunology.

Prostaglandin Concentrations in Ovine Maternal and Fetal Tissues at Late Gestation

S. Lye, J. Challis, D. Olson, 1986, Pediatric Research.

Early changes in prostaglandin concentrations in ovine maternal and fetal plasma, amniotic fluid and from dispersed cells of intrauterine tissues before the onset of ACTH-induced pre-term labour.

S. Lye, J. Challis, K. Skinner, 1984, Journal of reproduction and fertility.

S. Lye, J. Challis, W. Gibb, 2022 .

ACTH-induced preterm labour in the ewe is associated with increased mRNA and protein levels of myometrial gap junction protein, connexin-43.

S. Lye, B. Nicholson, C. McNutt, 1994, The Journal of endocrinology.

Tracking of vitamin D status from childhood to early adulthood and its association with peak bone mass.

P. Holt, C. Pennell, K. Zhu, 2017, The American journal of clinical nutrition.

Parathyroid Hormone-Related Protein Treatment of Pregnant Rats Delays the Increase in Connexin 43 and Oxytocin Receptor Expression in the Myometrium1

Jennifer A. Mitchell, S. Lye, Susan D. Wong, 2003, Biology of reproduction.

A New Role for Monocytes in Modulating Myometrial Inflammation During Human Labor1

S. Lye, O. Shynlova, B. Chanrachakul, 2014, Biology of reproduction.

Short Title: MONOCYTES MODULATE MYOMETRIAL INFLAMMATION

S. Lye, O. Shynlova, B. Chanrachakul, 2014 .

Static Mechanical Loading Influences the Expression of Extracellular Matrix and Cell Adhesion Proteins in Vaginal Cells Derived From Premenopausal Women With Severe Pelvic Organ Prolapse

S. Lye, O. Shynlova, H. Drutz, 2016, Reproductive Sciences.

Comparative Characterization of Vaginal Cells Derived From Premenopausal Women With and Without Severe Pelvic Organ Prolapse

S. Lye, O. Shynlova, H. Drutz, 2016, Reproductive Sciences.

Focal Adhesion Signaling in the Rat Myometrium Is Abruptly Terminated with the Onset of Labor1.

S. Lye, D. MacPhee, 2000, Endocrinology.

Focal adhesion signaling in the rat myometrium is abruptly terminated with the onset of labor.

S. Lye, D. MacPhee, 2000, Endocrinology.

Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibits Extra Villous Trophoblast Migration: The Impact of Bacterial and Viral Infection

S. Lye, C. Peng, W. Gibb, 2019, Cells.

Glucocorticoid Regulation of Human and Ovine Parturition: The Relationship Between Fetal Hypothalamic-Pituitary-Adrenal Axis Activation and Intrauterine Prostaglandin Production

S. Lye, N. Alfaidy, J. Challis, 2001, Biology of reproduction.

Identification of Two Regulatory Elements within the Promoter Region of the Mouse Connexin 43 Gene (*)

J. Rossant, S. Lye, X. Bai, 1995, The Journal of Biological Chemistry.

Placenta and fetal membranes in human parturition and preterm delivery--a workshop report.

S. Lye, C. Ticconi, 2002, Placenta.

Increased expression of the rat myometrial oxytocin receptor messenger ribonucleic acid during labor requires both mechanical and hormonal signals.

S. Lye, Z. Chen, Zhi-Qing. Chen, 1998, Biology of reproduction.

Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1

S. Lye, S. Renaud, C. Dunk, 2020, bioRxiv.

The selective progesterone receptor modulator, Promegestone, delays term parturition and prevents systemic inflammation-mediated preterm birth in mice.

S. Lye, O. Shynlova, S. Mesiano, 2021, American journal of obstetrics and gynecology.

Peripheral maternal leukocytes are activated in response to cytokines secreted by uterine tissues of pregnant women

S. Lye, O. Shynlova, Tali Farine, 2017, Cellular &Molecular Immunology.

Development of the Fetal Hypothalamic-Pituitary-Adrenal-Placental Axis: Implications for Postnatal Health

F. Petraglia, S. Lye, D. Sloboda, 2009 .

Prostaglandin F2alpha potentiates cortisol production by stimulating 11beta-hydroxysteroid dehydrogenase 1: a novel feedback loop that may contribute to human labor.

J. Macdonald, S. Lye, N. Alfaidy, 2001, The Journal of clinical endocrinology and metabolism.

Fetal-to-Maternal Progression of Prostaglandin H2 Synthase-2 Expression in Ovine Intrauterine Tissues During the Course of Labor1

S. Lye, J. Challis, W. Gibb, 2000, Biology of reproduction.

The molecular basis of labour and tocolysis

S. Lye, R. Casper, Y. Stevens, 1998 .

Is the attenuation of beta-adrenergic agonist efficacy during labor caused by elevated prostaglandin E levels?

S. Lye, M. Oskamp, P. Bernstein, 1998, American journal of obstetrics and gynecology.

Functional Evaluation of STOX1 (STORKHEAD-BOX PROTEIN 1) in Placentation, Preeclampsia, and Preterm Birth.

M. van Dijk, B. Cox, S. Lye, 2020, Hypertension.

MicroRNA-218-5p Promotes Endovascular Trophoblast Differentiation and Spiral Artery Remodeling.

Yan-Ling Wang, S. Lye, G. Fu, 2018, Molecular therapy : the journal of the American Society of Gene Therapy.

Quantitative large scale gene expression profiling from human stem cell culture micro samples using multiplex pre-amplification

S. Lye, S. Okino, M. Kibschull, 2016, Systems biology in reproductive medicine.

Effects of the Global Coronavirus Disease-2019 Pandemic on Early Childhood Development: Short- and Long-Term Risks and Mitigating Program and Policy Actions

A. Stein, J. Leckman, S. Lye, 2020, The Journal of Pediatrics.

Characterization of connexin31.1-deficient mice reveals impaired placental development.

K. Willecke, M. Kretz, S. Lye, 2007, Developmental biology.

Parathyroid hormone-induced up-regulation of connexin-43 messenger ribonucleic acid (mRNA) is mediated by sequences within both the promoter and the 3'untranslated region of the mRNA.

S. Lye, J. Mitchell, Z. Chen, 2001, Endocrinology.

Expression and Organization of Basement Membranes and Focal Adhesion Proteins in Pregnant Myometrium is Regulated by Uterine Stretch

S. Lye, O. Shynlova, M. Chow, 2009, Reproductive Sciences.

Immunophenotyping and activation status of maternal peripheral blood leukocytes during pregnancy and labour, both term and preterm

S. Lye, O. Shynlova, L. Briollais, 2017, Journal of cellular and molecular medicine.

Rat uterine myometrium contains the gap junction protein connexin45, which has a differing temporal expression pattern from connexin43.

Y. Sadovsky, S. Lye, E. Beyer, 1996, American journal of obstetrics and gynecology.

Activin is a local regulator of human cytotrophoblast cell differentiation.

S. Lye, I. Caniggia, J. Cross, 1997, Endocrinology.

Maternal neutrophil apoptosis in normal pregnancy, preeclampsia, and normotensive intrauterine growth restriction.

J. Marshall, S. Lye, P. von Dadelszen, 1999, American journal of obstetrics and gynecology.

Stretch-Induced Uterine Myocyte Differentiation During Rat Pregnancy: Involvement of Caspase Activation1

S. Lye, O. Shynlova, A. Dorogin, 2010, Biology of reproduction.

Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies.

M. Post, S. Lye, I. Caniggia, 1999, The Journal of clinical investigation.

Regulation of the Matricellular Proteins CYR61 (CCN1) and NOV (CCN3) by Hypoxia-Inducible Factor-1 (cid:1) and Transforming-Growth Factor- (cid:2) 3 in the Human Trophoblast

S. Lye, I. Gashaw, E. Winterhager, 2010 .

EGF modulates trophoblast migration through regulation of Connexin 40.

J. Kingdom, S. Lye, E. Winterhager, 2006, Placenta.

Macrophages Infiltrate the Human and Rat Decidua During Term and Preterm Labor: Evidence That Decidual Inflammation Precedes Labor1

S. Lye, O. Shynlova, Rebecca L. Jones, 2012, Biology of reproduction.

The expression of integrins and cadherins in normal human uterus and uterine leiomyomas.

S. Lye, M. Letarte, C. V. Taylor, 1996, American journal of obstetrics and gynecology.

Expression of prostaglandin E2 receptor subtypes in the developing sheep brainstem.

S. Lye, T. Tai, S. Adamson, 1998, Brain research. Molecular brain research.

Prostanoid concentrations in maternal/fetal plasma and amniotic fluid and intrauterine tissue prostanoid output in relation to myometrial contractility during the onset of adrenocorticotropin-induced preterm labor in sheep.

S. Lye, J. Challis, K. Skinner, 1985, Endocrinology.

Progesterone and Gravidity Differentially Regulate Expression of Extracellular Matrix Components in the Pregnant Rat Myometrium1

Jennifer A. Mitchell, S. Lye, O. Shynlova, 2004, Biology of reproduction.

Changes in pituitary responses to synthetic ovine corticotrophin releasing factor in fetal sheep.

S. Lye, J. Challis, L. Norman, 1985, Canadian journal of physiology and pharmacology.

Overexpression of miR-210-3p Impairs Extravillous Trophoblast Functions Associated with Uterine Spiral Artery Remodeling

S. Lye, G. Fu, C. Peng, 2021, International journal of molecular sciences.

Cytokine signaling, inflammation, innate immunity and preterm labour - a workshop report.

S. Lye, J. Challis, V. Blank, 2008, Placenta.

Differential activation of the connexin 43 promoter by dimers of activator protein-1 transcription factors in myometrial cells.

Jennifer A. Mitchell, S. Lye, 2005, Endocrinology.

Maternal Vitamin D Status During Pregnancy and Bone Mass in Offspring at 20 Years of Age: A Prospective Cohort Study

C. Pennell, K. Zhu, J. Walsh, 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

WITHDRAWN: Genetic epidemiological studies of preterm birth: Guidelines for research

B. Jacobsson, L. Muglia, C. Pennell, 2006 .

Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsia.

M. Post, S. Lye, J. Winter, 2000, Placenta.

Comparison of leucine enkephalin and adrenocorticotrophin effects on adrenal function in fetal and adult sheep.

S. Lye, J. Challis, J. Bousquet, 1984, Journal of reproduction and fertility.

Maternal Vascular Malperfusion and Adverse Perinatal Outcomes in Low-Risk Nulliparous Women.

B. Hoffman, J. Kingdom, S. Lye, 2017, Obstetrics and gynecology.

Expression and Localization of the Contractile Prostaglandin F Receptor in Pregnant Rat Myometrium in Late Gestation, Labor, and Postpartum1

S. Lye, L. Myatt, D. MacPhee, 2001, Biology of reproduction.

Expression of Gsα, Connexin-43, Connexin-26, and EP1, 3, and 4 Receptors in Myometrium of Prelabor Singleton Versus Multiple Gestations and the Effects of Mechanical Stretch and Steroids on Gsα

G. Milligan, S. Lye, T. Teoh, 2002, The Journal of the Society for Gynecologic Investigation: JSGI.

Expression of Gsalpha, connexin-43, connexin-26, and EP1, 3, and 4 receptors in myometrium of prelabor singleton versus multiple gestations and the effects of mechanical stretch and steroids on Gsalpha.

G. Milligan, S. Lye, T. Teoh, 2002, Journal of the Society for Gynecologic Investigation.

A Broad Spectrum Chemokine Inhibitor Prevents Preterm Labor but Not Microbial Invasion of the Amniotic Cavity or Neonatal Morbidity in a Non-human Primate Model

J. Munson, S. Lye, O. Shynlova, 2020, Frontiers in Immunology.

Expression and Localization of Alpha-Smooth Muscle and Gamma-Actins in the Pregnant Rat Myometrium1

S. Lye, O. Shynlova, A. Dorogin, 2005, Biology of reproduction.

Endocrine and paracrine regulation of birth at term and preterm.

S. Lye, J. Challis, W. Gibb, 2000, Endocrine reviews.

Expression of the multidrug resistance P-glycoprotein, (ABCB1 glycoprotein) in the human placenta decreases with advancing gestation.

J. Kingdom, S. Lye, D. Baczyk, 2006, Placenta.

Altered Fetal Pituitary-Adrenal Function in the Ovine Fetus Treated with RU486 and Meloxicam, an Inhibitor of Prostaglandin Synthase-II1

S. Lye, A. Bocking, J. Challis, 2000, Biology of reproduction.

DREAM Mediated Regulation of GCM1 in the Human Placental Trophoblast

J. Kingdom, S. Lye, J. Naranjo, 2013, PloS one.

Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblast

J. Kingdom, S. Lye, S. Drewlo, 2009, Cell Death and Differentiation.

TGF-beta 3 expression during umbilical cord development and its alteration in pre-eclampsia.

M. Post, S. Lye, I. Caniggia, 2002, Placenta.

Endoglin regulates trophoblast differentiation along the invasive pathway in human placental villous explants.

S. Lye, M. Letarte, I. Caniggia, 1997, Endocrinology.

Impact of bacterial and viral challenge on multidrug resistance in first- and third-trimester human placenta.

S. Lye, W. Gibb, S. Matthews, 2015, The American journal of pathology.

Connexin43 Interacts with NOV

K. Willecke, L. Klein-Hitpass, S. Lye, 2004, Journal of Biological Chemistry.

Gonadotropin-releasing hormone-regulated chemokine expression in human placentation.

S. Lye, V. Han, A. Babwah, 2009, American journal of physiology. Cell physiology.

Relaxin inhibits myometrial activity in the ovariectomized non-pregnant ewe.

J. M. Bradshaw, S. Lye, J. Kendall, 1981, Journal of reproduction and fertility.

Purification and characterization of pregnant sheep myometrium myosin light chain kinase.

S. Lye, M. Pato, E. Kerc, 1991, Archives of biochemistry and biophysics.

Association between liver‐specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease

L. Palmer, L. Beilin, C. Pennell, 2013, Hepatology.

Transcriptional Activity of Androgen Receptor Is Modulated by Two RNA Splicing Factors, PSF and p54nrb

S. Lye, Xuesen Dong, J. Challis, 2007, Molecular and Cellular Biology.

The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation.

M. van Dijk, M. Blankenstein, S. Lye, 2010, Human molecular genetics.

Landscape of Preterm Birth Therapeutics and a Path Forward

S. Lye, O. Shynlova, J. Paul, 2021, Journal of clinical medicine.

Insulin-like growth factor-I receptor-mediated vasculogenesis/angiogenesis in human lung development.

Stephen J Lye, Martin Post, A. Tanswell, 2003, American journal of respiratory cell and molecular biology.

Genetic epidemiologic studies of preterm birth: guidelines for research.

Scott M. Williams, Siobhan M. Dolan, B. Jacobsson, 2007, American journal of obstetrics and gynecology.

Efficient derivation of human trophoblast stem cells from primed pluripotent stem cells

G. Pan, A. Nagy, S. Lye, 2021, Science Advances.

Human embryonic fibroblasts support single cell enzymatic expansion of human embryonic stem cells in xeno-free cultures.

A. Nagy, S. Lye, M. Mileikovsky, 2011, Stem cell research.

Maternal metabolic, immune, and microbial systems in late pregnancy vary with malnutrition in mice†

T. DeSantis, S. Lye, C. Chehoud, 2018, Biology of Reproduction.

Approaches to Evaluate Gene-Environment Interactions Underlying the Developmental Origins of Health and Disease

L. Palmer, C. Pennell, C. Relton, 2009 .

The Ontario Birth Study: A prospective pregnancy cohort study integrating perinatal research into clinical care

N. Okun, J. Jenkins, J. Knight, 2018, Paediatric and perinatal epidemiology.

Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia.

S. Lye, G. Fu, C. Peng, 2011, The American journal of pathology.

Extracellular vesicle RNAs reflect placenta dysfunction and are a biomarker source for preterm labour

L. Hood, D. Baxter, S. Lye, 2018, Journal of cellular and molecular medicine.

Parental ethnicity and placental maternal vascular malperfusion pathology in healthy nulliparous women.

J. Kingdom, S. Lye, N. Melamed, 2018, Placenta.

Maternal Whole Blood Gene Expression at 18 and 28 Weeks of Gestation Associated with Spontaneous Preterm Birth in Asymptomatic Women

Siobhan M. Dolan, A. Lyon, C. Pennell, 2016, PloS one.

Activation of ovine fetal adrenal function by pulsatile or continuous administration of adrenocorticotropin-(1-24). I. Effects on fetal plasma corticosteroids.

S. Lye, J. Challis, B. Mitchell, 1983, Endocrinology.

The Pattern of Glucocorticoid and Estrogen Receptors May Explain Differences in Steroid Dependency of Intrauterine Prostaglandin Production at Parturition in Sheep

S. Lye, J. Challis, W. Gibb, 2006, The Journal of the Society for Gynecologic Investigation: JSGI.

Expression of Bone Morphogenetic Protein-1 in vaginal tissue of women with severe pelvic organ prolapse.

M. Bortolini, R. Castro, S. Lye, 2011, American journal of obstetrics and gynecology.

Comparative analysis of gene expression in maternal peripheral blood and monocytes during spontaneous preterm labor

N. Price, A. Paquette, S. Lye, 2018, American journal of obstetrics and gynecology.

Myometrial immune cells contribute to term parturition, preterm labour and post-partum involution in mice

S. Lye, O. Shynlova, Yunqing Li, 2012, Journal of cellular and molecular medicine.

Expression and regulation of prostaglandin receptors in the human placenta and fetal membranes at term and preterm.

S. Lye, N. Alfaidy, A. Bocking, 2010, Reproduction, fertility, and development.

Expression of connexin-43 and connexin-26 in the rat myometrium during pregnancy and labor is differentially regulated by mechanical and hormonal signals.

S. Lye, A. Orsino, C. Ou, 1997, Endocrinology.

Connexin-26 and connexin-43 are differentially expressed and regulated in the rat myometrium throughout late pregnancy and with the onset of labor.

S. Lye, A. Orsino, C. V. Taylor, 1996, Endocrinology.

E. Kasten, S. Lye, Guoli Zhou, 2020, Reproductive Sciences.

MicroRNA‐transcriptome networks in whole blood and monocytes of women undergoing preterm labour

N. Price, A. Paquette, S. Lye, 2019, Journal of cellular and molecular medicine.

Ovine fetal urachus--physiological and hormonal control of its contractile activity.

S. Lye, J. Challis, C. L. Freitag, 1988, The American journal of physiology.

Inhibition of infection-mediated preterm birth by administration of broad spectrum chemokine inhibitor in mice

S. Lye, O. Shynlova, Yunqing Li, 2014, Journal of cellular and molecular medicine.

Social vulnerability, parity and food insecurity in urban South African young women: the healthy life trajectories initiative (HeLTI) study

S. Norris, S. Lye, A. W. Kim, 2021, Journal of Public Health Policy.

Nurturing care: promoting early childhood development

J. Leckman, M. Hanson, Z. Bhutta, 2017, The Lancet.

Environmental, Social, and Structural Constraints for Health Behavior: Perceptions of Young Urban Black Women During the Preconception Period-A Healthy Life Trajectories Initiative.

S. Norris, E. Cohen, S. Lye, 2019, Journal of nutrition education and behavior.

Prostaglandin F2 Potentiates Cortisol Production by Stimulating 11 -Hydroxysteroid Dehydrogenase 1: A Novel Feedback Loop That May Contribute to Human Labor

J. Macdonald, S. Lye, N. Alfaidy, 2001 .

Estradiol modulation of ovine uterine activity.

S. Lye, J. Challis, R. Windmoller, 1983, Canadian journal of physiology and pharmacology.

Glial cell missing-1 mediates over-expression of tissue inhibitor of metalloproteinase-4 in severe pre-eclamptic placental villi.

J. Kingdom, S. Lye, S. Drewlo, 2011, Human reproduction.

Expression, localization and function of prostaglandin receptors in myometrium.

Stephen J Lye, Leslie Myatt, S. Lye, 2004, Prostaglandins, leukotrienes, and essential fatty acids.

Failure of ritodrine to prevent preterm labor in the sheep.

S. Lye, R. Casper, J. Brooks, 1992, American journal of obstetrics and gynecology.

Association of a Body Mass Index Genetic Risk Score with Growth throughout Childhood and Adolescence

D. Lawlor, N. Timpson, N. Warrington, 2013, PloS one.

Effect of Labor on Glucocorticoid Receptor (GRTotal, GRα, and GRβ) Proteins in Ovine Intrauterine Tissues

S. Lye, J. Challis, W. Gibb, 2003, The Journal of the Society for Gynecologic Investigation: JSGI.

Ontogeny and Regulation of Ovine Placental Prostaglandin E2 Synthase1

S. Lye, J. Challis, W. Gibb, 2002, Biology of reproduction.

Temporal expression of prostaglandin H synthase type 2 (PGHS-2) and P450(C17)in ovine placentomes with the natural onset of labour.

S. Lye, F. Labrie, J. Challis, 2000, Placenta.

Dexamethasone partially protects the myometrium against beta-adrenergic agonist-induced desensitization in vivo in the rat.

S. Lye, N. MacLusky, Z. Herman-Gnjidic, 1994, American journal of obstetrics and gynecology.

Dexamethasone reverses the labor-associated myometrial desensitization to beta-adrenergic agonists in the rat.

S. Lye, N. MacLusky, L. Kočan, 1993, American journal of obstetrics and gynecology.

Characterization of myometrial desensitization to beta-adrenergic agonists.

S. Lye, B. A. Dayes, 1990, Canadian journal of physiology and pharmacology.

Effects of beta-adrenergic agonist infusions on myometrial activity and plasma prostaglandin levels in the nonpregnant sheep.

S. Lye, R. Casper, P. Christopher, 1987, Canadian journal of physiology and pharmacology.

Beta-adrenergic receptor agonist infusion increases plasma prostaglandin F levels in pregnant sheep.

S. Lye, R. Casper, 1987, American journal of obstetrics and gynecology.

Myometrial desensitization to continuous but not to intermittent beta-adrenergic agonist infusion in the sheep.

S. Lye, R. Casper, 1986, American journal of obstetrics and gynecology.

S. Lye, Siliang Li, M. Kibschull, 2020, American Journal of Obstetrics and Gynecology.

Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia

Lisa X. Yu, J. Sled, J. Freedman, 2017, Nature Communications.

Failure of Decidualization and Maternal Immune Tolerance Underlies Uterovascular Resistance in Intra Uterine Growth Restriction

J. Kingdom, S. Lye, S. Keating, 2019, Front. Endocrinol..

A Broad-Spectrum Chemokine Inhibitor Blocks Inflammation-Induced Myometrial Myocyte–Macrophage Crosstalk and Myometrial Contraction

S. Lye, O. Shynlova, Adam Boros-Rausch, 2021, Cells.

SURVIVING AND THRIVING HIV-FREE: REPORT OF THE 4TH HIV-EXPOSED UNINFECTED CHILD AND ADOLESCENT WORKSHOP

Galloway, S. Lye, B. Daelmans, 2020 .

Early life origins of obesity.

C. Pennell, S. Lye, J. Newnham, 2009, Obstetrics and gynecology clinics of North America.

Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor coregulators, p54nrb and PSF.

M. Gleave, P. Rennie, S. Lye, 2011, Molecular endocrinology.

Mechanical stretch regulates hypertrophic phenotype of the myometrium during pregnancy.

S. Lye, O. Shynlova, R. Kwong, 2010, Reproduction.

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3

M. Gassmann, M. Post, S. Lye, 2000 .

EBF1 Gene mRNA Levels in Maternal Blood and Spontaneous Preterm Birth

S. Lye, Guoli Zhou, C. Holzman, 2020, Reproductive Sciences.

Pro‐inflammatory signals induce 20α‐HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal

S. Lye, O. Shynlova, S. Mesiano, 2021, Journal of cellular and molecular medicine.

HoxA13 Regulates Phenotype Regionalization of Human Pregnant Myometrium.

Steven J. M. Jones, S. Lye, O. Shynlova, 2015, The Journal of clinical endocrinology and metabolism.

Identification and Characterization of the Protein-associated Splicing Factor as a Negative Co-regulator of the Progesterone Receptor*

S. Lye, Xuesen Dong, J. Challis, 2005, Journal of Biological Chemistry.

Leukocyte driven-decidual angiogenesis in early pregnancy

S. Lye, B. Croy, C. Dunk, 2014, Cellular and Molecular Immunology.

Investigation of Genetic Variants, Birthweight and Hypothalamic-Pituitary-Adrenal Axis Function Suggests a Genetic Variant in the SERPINA6 Gene Is Associated with Corticosteroid Binding Globulin in the Western Australia Pregnancy Cohort (Raine) Study

C. Pennell, S. Lye, L. Briollais, 2014, PloS one.

Association of Genetic Loci With Glucose Levels in Childhood and Adolescence

David M. Evans, I. Ntalla, M. McCarthy, 2011, Diabetes.

Common variants at 12q15 and 12q24 are associated with infant head circumference

Aad van der Lugt, Xavier Estivill, Sudha Seshadri, 2013, Nature Genetics.

Variants near CCNL1/LEKR1 and in ADCY5 and fetal growth characteristics in different trimesters.

A. Hofman, N. Warrington, L. Palmer, 2011, The Journal of clinical endocrinology and metabolism.

MicroRNA‐transcriptome networks in whole blood and monocytes of women undergoing preterm labour

N. Price, A. Paquette, S. Lye, 2019, bioRxiv.

Whole Blood Gene Expression Profile Associated with Spontaneous Preterm Birth in Women with Threatened Preterm Labor

Hon Nian Chua, H. Chua, C. Pennell, 2014, PloS one.

To serve and to protect: the role of decidual innate immune cells on human pregnancy

S. Lye, C. Dunk, Jianhong Zhang, 2015, Cell and Tissue Research.

Possible role of cortisol in the stimulation of cortisol-binding capacity in the plasma of fetal sheep.

S. Lye, J. Challis, E. A. Nancekievill, 1985, Endocrinology.

Fat mass and obesity-associated obesity-risk genotype is associated with lower foetal growth: an effect that is reversed in the offspring of smoking mothers

A. Hofman, N. Warrington, L. Palmer, 2011, Journal of Developmental Origins of Health and Disease.

Hypothalamic-pituitary-adrenal axis activity under resting conditions and cardiovascular risk factors in adolescents

L. Beilin, C. Pennell, Trevor A. Mori, 2016, Psychoneuroendocrinology.

Albumin decrease is associated with spontaneous preterm delivery within 48 h in women with threatened preterm labor.

Tony Pawson, Hon Nian Chua, Stephen Tate, 2015, Journal of proteome research.

Ovine fetal adrenal maturation at term and during fetal ACTH administration: evidence that the modulating effect of cortisol may involve cAMP.

S. Lye, J. Challis, J. Welsh, 1986, Canadian journal of physiology and pharmacology.

Myometrial activation: Novel concepts underlying labor.

S. Lye, O. Shynlova, Lubna Nadeem, 2020, Placenta.

TGFb1 suppresses the activation of distinct dNK subpopulations in preeclampsia

S. Lye, O. Shynlova, I. Caniggia, 2018, EBioMedicine.

Fibroblast growth factor receptor-1 and neonatal compensatory lung growth after exposure to 95% oxygen.

A. Tanswell, H. Frndova, S. Lye, 2003, American journal of respiratory and critical care medicine.

Associations between hypothalamic-pituitary-adrenal axis function and peak bone mass at 20years of age in a birth cohort.

C. Pennell, K. Zhu, J. Walsh, 2016, Bone.

Material and Relational Difficulties: The Impact of the Household Environment on the Emotional Well-Being of Young Black Women Living in Soweto, South Africa

S. Norris, E. Cohen, S. Lye, 2020 .

Initiation of parturition

S. Lye, 1996 .

Reprint of: Myometrial activation: Novel concepts underlying labor.

S. Lye, O. Shynlova, Lubna Nadeem, 2020, Placenta.

Evidence for an intrinsic control of myometrial contractile periodicity in sheep during pregnancy.

S. Lye, 1992, Journal of reproduction and fertility.

Local and systemic control of myometrial contractile activity during labour in the sheep.

S. Lye, C. L. Freitag, 1990, Journal of reproduction and fertility.

Partial reversal of the myometrial progesterone 'block' in the non-pregnant ewe in vivo by oestradiol-17 beta.

S. Lye, D. G. Porter, 1983, Journal of reproduction and fertility.

The Initiation and Inhibition of Labor - Toward a Molecular Understanding

S. Lye, 1994 .

Mechanical Stretch Regulates Hypertrophic Phenotype of the Myometrium During 1

S. Lye, O. Shynlova, R. Kwong, 2009 .

Integration of endocrine and mechanical signals in the regulation of myometrial functions during pregnancy and labour.

S. Lye, S. Jaffer, O. Shynlova, 2009, European journal of obstetrics, gynecology, and reproductive biology.

Human dNK cell function is differentially regulated by extrinsic cellular engagement and intrinsic activating receptors in first and second trimester pregnancy

S. Lye, S. Keating, Rebecca L. Jones, 2015, Cellular and Molecular Immunology.

Vascular-leukocyte interactions: mechanisms of human decidual spiral artery remodeling in vitro.

S. Lye, Rebecca L. Jones, C. Dunk, 2010, The American journal of pathology.

Longitudinal Trajectories of Television Watching Across Childhood and Adolescence Predict Bone Mass at Age 20 Years in the Raine Study

L. Straker, C. Pennell, J. McVeigh, 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The role of early life growth development, the FTO gene and exclusive breastfeeding on child BMI trajectories.

S. Lye, L. Briollais, Y. Wu, 2017, International journal of epidemiology.

Gender differences in the relationships between lean body mass, fat mass and peak bone mass in young adults

C. Pennell, K. Zhu, A. Smith, 2014, Osteoporosis International.

Expression and regulation of the messenger ribonucleic acid encoding the prostaglandin F2α receptor in the rat myometrium during pregnancy and labor

S. Lye, Zhi-Qing. Chen, C. Ou, 2000 .

Maternal malnutrition impacts placental morphology and transport. An origin for poor offspring growth and vulnerability to disease

S. Lye, E. Matysiak-Zablocki, M. Kibschull, 2019, bioRxiv.

Elevated mRNA expression of PGF2α receptor splice variant 2(FP-V2) in human decidua is associated with incomplete mifepristone–misoprostol-induced early medical abortion by regulation of interleukin-8

Wei Liu, S. Lye, W. Han, 2016, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

Probiotic Lactobacillus rhamnosus GR-1 is a unique prophylactic agent that suppresses infection-induced myometrial cell responses

S. Lye, Bona Kim, O. Shynlova, 2019, Scientific Reports.

A life course approach to the relationship between fetal growth and hypothalamic-pituitary-adrenal axis function.

C. Pennell, Carol A. Wang, S. Lye, 2021, The Journal of clinical endocrinology and metabolism.

Hypoxia alters the expression of ACE2 and TMPRSS2 SARS-CoV-2 cell entry mediators in hCMEC/D3 brain endothelial cells

S. Lye, S. Matthews, E. Bloise, 2021, Microvascular Research.

All Our Babies Cohort Study: recruitment of a cohort to predict women at risk of preterm birth through the examination of gene expression profiles and the environment

Siobhan M. Dolan, A. Lyon, C. Pennell, 2010, BMC pregnancy and childbirth.

HoxA13 Stimulates Myometrial Cells to Secrete IL-1β and Enhance the Expression of Contraction-Associated Proteins.

L. Fazli, Yue Yu, S. Lye, 2016, Endocrinology.

Understanding Preterm Labor

S. Lye, N. Alfaidy, J. Challis, 2001, Annals of the New York Academy of Sciences.

Extravillous Trophoblast and Endothelial Cell Crosstalk Mediates Leukocyte Infiltration to the Early Remodeling Decidual Spiral Arteriole Wall

S. Lye, J. Aplin, Rebecca L. Jones, 2017, The Journal of Immunology.

Expression and function of myometrial PSF suggest a role in progesterone withdrawal and the initiation of labor.

M. Gleave, S. Lye, O. Shynlova, 2012, Molecular endocrinology.

Protocol for a randomised trial evaluating a preconception-early childhood telephone-based intervention with tailored e-health resources for women and their partners to optimise growth and development among children in Canada: a Healthy Life Trajectory Initiative (HeLTI Canada)

P. Szatmari, C. Dennis, M. Tremblay, 2021, BMJ Open.

A Novel In Vitro Model of Trophoblast-Mediated Decidual Blood Vessel Remodeling

J. Rossant, S. Lye, D. Baczyk, 2003, Laboratory Investigation.

Restoration of trophoblast invasive capability in preeclamptic villous expiants by antisense knock-down of TGFβ3

M. Post, S. Lye, I. Caniggia, 1998 .

SARS-CoV-2 cell entry gene ACE2 expression in immune cells that infiltrate the placenta in infection-associated preterm birth

S. Lye, J. Zhang, E. Bloise, 2020, medRxiv.

Gap junctions are required for trophoblast proliferation in early human placental development.

J. Rossant, S. Lye, E. Winterhager, 2004, Placenta.

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)

M. Gassmann, M. Post, S. Lye, 2000, The Journal of clinical investigation.

Cord blood myostatin concentrations by gestational diabetes mellitus and fetal sex

Z. Pausova, J. Kingdom, S. Lye, 2023, Frontiers in Endocrinology.

Myometrial programming: a new concept underlying the regulation of myometrial function during pregnancy

Jennifer A. Mitchell, S. Lye, O. Shynlova, 2007 .

The Molecular Role of Connexin 43 in Human Trophoblast Cell Fusion1

J. Kingdom, S. Lye, S. Drewlo, 2012, Biology of reproduction.

Evaluating depression and anxiety throughout pregnancy and after birth: impact of the COVID-19 pandemic

J. Knight, S. Lye, R. Levitan, 2022, American Journal of Obstetrics & Gynecology MFM.

MicroRNA-378a-5p promotes trophoblast cell survival, migration and invasion by targeting Nodal

S. Lye, G. Fu, Burton B. Yang, 2012, Journal of Cell Science.

Intramolecular interactions between the AF3 domain and the C-terminus of the human progesterone receptor are mediated through two LXXLL motifs.

S. Lye, J. Challis, X. Dong, 2004, Journal of molecular endocrinology.

Dual energy X-ray absorptiometry compared with anthropometry in relation to cardio-metabolic risk factors in a young adult population: Is the ‘Gold Standard’ tarnished?

L. Beilin, L. Beilin, C. Pennell, 2016 .

Discordant accelerated pulmonary maturation after adrenocorticotropic hormone-induced labor in twin sheep fetuses.

S. Lye, J. Challis, G. Vilos, 1988, American journal of obstetrics and gynecology.

Characterization and novel analyses of acute stress response patterns in a population-based cohort of young adults: influence of gender, smoking, and BMI

C. Pennell, S. Lye, J. Newnham, 2016, Stress.

HER1 Signaling Mediates Extravillous Trophoblast Differentiation in Humans1

S. Lye, S. Keating, C. Dunk, 2010, Biology of reproduction.

Possible role of uterine contractions in the short-term fluctuations of plasma ACTH concentration in fetal sheep.

S. Lye, J. Challis, M. Wlodek, 1985, The Journal of endocrinology.

Prophylactic Strategies for Preventing Pre-eclampsia: A Network Meta-analysis of Randomized Controlled Trials.

N. Tan, S. Lye, Yuanhui Liu, 2022, American journal of obstetrics and gynecology.

Association between maternal cannabis use and birth outcomes: an observational study

J. Knight, J. Brooks, R. Hung, 2020, BMC Pregnancy and Childbirth.

Rat myometrial activity in vivo: effects of oestradiol-17 beta and progesterone in relation to the concentrations of cytoplasmic progesterone receptors.

J. M. Bradshaw, S. Lye, S. Downing, 1978, The Journal of endocrinology.

Phenotypes of Pregnant Women Who Subsequently Develop Hypertension in Pregnancy

J. Kingdom, S. Lye, J. Parker, 2018, Journal of the American Heart Association.

Differentiation of patient-specific void urine-derived human induced pluripotent stem cells to fibroblasts and skeletal muscle myocytes

S. Lye, O. Shynlova, M. Kibschull, 2023, Scientific Reports.

Protocol for a cluster randomised trial evaluating a multifaceted intervention starting preconceptionally—Early Interventions to Support Trajectories for Healthy Life in India (EINSTEIN): a Healthy Life Trajectories Initiative (HeLTI) Study

C. Dennis, K. Joseph, P. Jha, 2021, BMJ Open.

To serve and to protect: the role of decidual innate immune cells on human pregnancy

S. Lye, C. Dunk, Jianhong Zhang, 2015, Cell and Tissue Research.

Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia

Lisa X. Yu, J. Sled, J. Freedman, 2017, Nature Communications.

Combination of histochemical analyses and micro-MRI reveals regional changes of the murine cervix in preparation for labor

J. Sled, S. Lye, O. Shynlova, 2021, Scientific Reports.

The Circulating Proangiogenic Factors CYR61 (CCN1) and NOV (CCN3) Are Significantly Decreased in Placentae and Sera of Preeclamptic Patients

S. Lye, E. Winterhager, A. Gellhaus, 2007, Reproductive Sciences.

Decreased expression of the angiogenic regulators CYR61 (CCN1) and NOV (CCN3) in human placenta is associated with pre-eclampsia.

R. Kimmig, S. Lye, E. Winterhager, 2006, Molecular human reproduction.

Relation between fetal arterial PO2 and oxytocin-induced uterine contractions in pregnant sheep.

S. Lye, J. Challis, M. Wlodek, 1984, Canadian journal of physiology and pharmacology.

Exclusive breastfeeding can attenuate body-mass-index increase among genetically susceptible children: A longitudinal study from the ALSPAC cohort

C. Dennis, S. Lye, L. Briollais, 2020, PLoS genetics.

Nurturing Care for Young Children under Conditions of Fragility and Conflict.

S. Lye, L. Richter, K. Proulx, 2018, New directions for child and adolescent development.

Changes in vascular extracellular matrix composition during decidual spiral arteriole remodeling in early human pregnancy.

S. Lye, J. Aplin, Rebecca L. Jones, 2016, Histology and Histopathology.

Using Precision Medicine with a Neurodevelopmental Perspective to Study Inflammation and Depression

J. Knight, R. Hung, S. Lye, 2020, Current Psychiatry Reports.

Placental Connexins of Mice and Men

S. Lye, E. Winterhager, M. Kibschull, 2005 .

Stimulation of ovine myometrial activity by 6-keto prostaglandin E1.

S. Lye, J. Challis, D. Olson, 1983, Prostaglandins.

Modulation of ovine myometrial activity by estradiol-17 beta. The possible involvement of prostaglandins.

S. Lye, J. Challis, C. Sprague, 1983, Canadian journal of physiology and pharmacology.

Inhibition by PGI-2 of myometrial activity in vivo in non-pregnant ovariectomized sheep.

S. Lye, J. Challis, 1982, Journal of reproduction and fertility.

Combinatorial extracellular matrix microarray identifies novel bioengineered substrates for xeno-free culture of human pluripotent stem cells.

B. Hinz, C. Simmons, J. Audet, 2020, Biomaterials.

Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae.

S. Lye, O. Shynlova, M. Parsons, 2018, Journal of visualized experiments : JoVE.

Modulation by cortisol of adrenocorticotropin-induced activation of adrenal function in fetal sheep.

S. Lye, J. Challis, B. Mitchell, 1985, Endocrinology.

The effects of pulsed adrenocorticotropin1-24 administration to one twin on the endocrine and uterine activity changes during twin pregnancy in sheep.

S. Lye, J. Challis, A. Brooks, 1988, Biology of reproduction.

Probiotic Lactobacillus rhamnosus GR-1 is a unique prophylactic agent that suppresses infection-induced myometrial cell responses

S. Lye, Bona Kim, O. Shynlova, 2019, Scientific Reports.

Methodes de diagnostic d'une regulation necessaire de l'invasion trophoblastique

S. Lye, Isabella Caniggia, Martin Post, 1998 .

Preeclampsia is associated with low placental transthyretin levels.

S. Lye, Zhenyu Zhang, D. Baczyk, 2016, Taiwanese journal of obstetrics & gynecology.

A POSSIBLE MECHANISM FOR NEGATIVE REGULATION OF CELL GROWTH IN CHORIOCARCINOMA CELLS*□ S

K. Willecke, L. Klein-Hitpass, S. Lye, 2004 .

Androstenedione metabolism in the late gestation sheep fetus.

S. Lye, J. Challis, B. Mitchell, 1986, Endocrinology.

Uterine artery and umbilical vein blood flow are unaffected by moderate habitual physical activity during pregnancy

S. Lye, M. Seed, G. Wells, 2019, Prenatal diagnosis.

Progesterone Via its Type-A Receptor Promotes Myometrial Gap Junction Coupling

S. Lye, O. Shynlova, S. Mesiano, 2017, Scientific Reports.

IMMUNOPATHOLOGY AND INFECTIOUS DISEASES Impact of Bacterial and Viral Challenge on Multidrug Resistance in First-and Third-Trimester Human Placenta

S. Lye, W. Gibb, S. Matthews, 2015 .

Activin Is a Local Regulator of Human Cytotrophoblast Cell Differentiation *

J. Cross, S. Lye, I. Caniggia, 1997 .

Mechanical stretch and progesterone differentially regulate activator protein-1 transcription factors in primary rat myometrial smooth muscle cells.

Jennifer A. Mitchell, S. Lye, O. Shynlova, 2004, American journal of physiology. Endocrinology and metabolism.

Expression and regulation of the messenger ribonucleic acid encoding the prostaglandin F(2alpha) receptor in the rat myometrium during pregnancy and labor.

S. Lye, Z. Chen, C. Ou, 2000, American journal of obstetrics and gynecology.

Regulation of trophoblast differentiation by TGFβ1 and TGF-β3, via endoglin

M. Post, S. Lye, M. Letarte, 1996 .

Accelerated prepartum maturation of the fetal sheep lung with physiological doses of andrenocorticotrophin.

S. Lye, J. Challis, G. Vilos, 1983, Journal of developmental physiology.

In Vivo Evidence of the Androgen Receptor in Association With Myometrial Cell Proliferation and Apoptosis

S. Lye, Haolong Li, Xuesen Dong, 2016, Reproductive Sciences.

Uterine Stretch Regulates Temporal and Spatial Expression of Fibronectin Protein and Its Alpha 5 Integrin Receptor in Myometrium of Unilaterally Pregnant Rats1

S. Lye, O. Shynlova, S. Williams, 2007, Biology of reproduction.

Prioritizing research for integrated implementation of early childhood development and maternal, newborn, child and adolescent health and nutrition platforms

Jai K. Das, L. Huicho, Z. Bhutta, 2017, Journal of global health.

Focal adhesion signaling in the rat myometrium is abruptly terminated with the onset of labor.

S. Lye, D. MacPhee, 2000, Endocrinology.

Sphingosine signalling regulates decidual NK cell angiogenic phenotype and trophoblast migration.

S. Lye, C. Dunk, Jianhong Zhang, 2013, Human reproduction.

Changes in vascular extracellular matrix composition during decidual spiral arteriole remodeling in early human pregnancy.

S. Lye, J. Aplin, Rebecca L. Jones, 2016, Histology and histopathology.

Heparin promotes soluble VEGF receptor expression in human placental villi to impair endothelial VEGF signaling

J. Kingdom, S. Lye, S. Drewlo, 2011, Journal of thrombosis and haemostasis : JTH.

CHAPTER 55 – Parturition

S. Lye, J. Challis, W. Gibb, 2006 .

Expression of genes encoding smooth muscle contractile proteins in vaginal tissue of women with and without pelvic organ prolapse

S. Lye, O. Shynlova, H. Drutz, 2012, Neurourology and urodynamics.

protein and its α5 integrin receptor in myometrium of unilaterally

S. Lye, O. Shynlova, S. Williams, 2007 .

Dual Energy X-Ray Absorptiometry Compared with Anthropometry in Relation to Cardio-Metabolic Risk Factors in a Young Adult Population: Is the ‘Gold Standard’ Tarnished?

L. Beilin, C. Pennell, S. Lye, 2016, PloS one.

Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin

S. Bandinelli, C. Lindgren, S. Ring, 2014, PLoS genetics.

Summary and synthesis of current knowledge.

Dafna Sussman, Stephen J Lye, Greg D Wells, 2016, Early human development.

Vascular-leukocyte interactions: mechanisms of human decidual spiral artery remodeling in vitro.

S. Lye, Rebecca L. Jones, C. Dunk, 2010, The American journal of pathology.

An in-vivo model to examine the electromyographic activity of isolated myometrial tissue from pregnant sheep.

S. Lye, C. L. Freitag, 1988, Journal of reproduction and fertility.

HoxA13 Stimulates Myometrial Cells to Secrete IL-1β and Enhance the Expression of Contraction-Associated Proteins.

L. Fazli, Yue Yu, S. Lye, 2016, Endocrinology.

TGFb1 suppresses the activation of distinct dNK subpopulations in preeclampsia

S. Lye, O. Shynlova, I. Caniggia, 2018, EBioMedicine.

Focal adhesion signaling in the rat myometrium is abruptly terminated with the onset of labor.

S. Lye, D. MacPhee, 2000, Endocrinology.

The impact of breastfeeding on FTO-related BMI growth trajectories: an application to the Raine pregnancy cohort study.

Taraneh Abarin, N. Warrington, C. Pennell, 2012, International journal of epidemiology.

Mitogen-activated protein kinases mediate stretch-induced c-fos mRNA expression in myometrial smooth muscle cells.

Mingyao Liu, S. Lye, O. Shynlova, 2002, American Journal of Physiology - Cell Physiology.