C. Baldock

发表

Transglutaminase-Mediated Cross-Linking of Tropoelastin to Fibrillin Stabilises the Elastin Precursor Prior to Elastic Fibre Assembly

A. Tarakanova, Michael P. Lockhart-Cairns, Helena Newandee, 2020, Journal of molecular biology.

Shape of tropoelastin, the highly extensible protein that controls human tissue elasticity

A. Oberhauser, T. Irving, M. Malfois, 2011, Proceedings of the National Academy of Sciences.

Defining Elastic Fiber Interactions by Molecular Fishing AFFINITY PURIFICATION AND MASS SPECTROMETRY APPROACH* □ S

A. Shuttleworth, C. Baldock, A. McGovern, 2009 .

The Angiogenic Inhibitor Long Pentraxin PTX3 Forms an Asymmetric Octamer with Two Binding Sites for FGF2*

A. J. Day, A. Mantovani, K. Kadler, 2010, The Journal of Biological Chemistry.

Fibrillin-rich microfibrils of the extracellular matrix: ultrastructure and assembly.

P. Purslow, C. Baldock, C. Kielty, 2001, Micron.

Nanostructure of fibrillin-1 reveals compact conformation of EGF arrays and mechanism for extensibility

J. G. Grossmann, M. Roessle, C. Baldock, 2006, Proceedings of the National Academy of Sciences.

Independent multimerization of Latent TGFβ Binding Protein-1 stabilized by cross-linking and enhanced by heparan sulfate

C. Baldock, C. Kielty, R. Steer, 2016, Scientific Reports.

Subunit Arrangement in GpsB, a Regulator of Cell Wall Biosynthesis

R. Lewis, E. Breukink, Michael P. Lockhart-Cairns, 2016, Microbial drug resistance.

A role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex dimerization during neurosecretion.

T. Jowitt, C. Baldock, J. Bella, 2008, Molecular biology of the cell.

A role for SNARE complex dimerization during neurosecretion

T. Jowitt, C. Baldock, J. Bella, 2008 .

Latent TGFβ complexes are transglutaminase cross-linked to fibrillin to facilitate TGFβ activation

Michael P. Lockhart-Cairns, J. Thomson, C. Baldock, 2022, Matrix biology : journal of the International Society for Matrix Biology.

Molecular model of human tropoelastin and implications of associated mutations

A. Tarakanova, M. Buehler, A. Weiss, 2018, Proceedings of the National Academy of Sciences.

The herpes viral transcription factor ICP4 forms a novel DNA recognition complex

A. Mould, T. Jowitt, Michael P. Lockhart-Cairns, 2017, Nucleic acids research.

Extracellular Regulation of Bone Morphogenetic Protein Activity by the Microfibril Component Fibrillin-1*

C. Baldock, R. Collins, A. Wohl, 2016, The Journal of Biological Chemistry.

Fibrillin microfibrils and elastic fibre proteins: Functional interactions and extracellular regulation of growth factors

J. Thomson, C. Baldock, M. Sherratt, 2019, Seminars in cell & developmental biology.

Assembly of fibrillin microfibrils governs extracellular deposition of latent TGFβ

C. Baldock, A. McGovern, C. Kielty, 2010, Journal of Cell Science.

The Dual PDZ Domain from Postsynaptic Density Protein 95 Forms a Scaffold with Peptide Ligand

J. Chipperfield, L. Bird, Michael P. Lockhart-Cairns, 2020, Biophysical journal.

Structural analysis of X-linked retinoschisis mutations reveals distinct classes which differentially effect retinoschisin function

Richard P. O. Jones, A. Roseman, C. A. Siebert, 2016, Human molecular genetics.

Differential Regulation of Elastic Fiber Formation by Fibulin-4 and -5*

Chun Guo, A. Shuttleworth, C. Baldock, 2009, The Journal of Biological Chemistry.

Dual role of the active site ‘lid’ regions of protochlorophyllide oxidoreductase in photocatalysis and plant development

N. Scrutton, L. Johannissen, T. Jowitt, 2020, The FEBS journal.

Heavy chain-1 of inter-α-inhibitor has an integrin-like structure with immune regulatory activities

J. Enghild, T. Jowitt, C. Baldock, 2019, bioRxiv.

Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation

J. Enghild, T. Jowitt, C. Baldock, 2020, The Journal of Biological Chemistry.

Lysyl oxidase–like 2 (LOXL2)–mediated cross-linking of tropoelastin

S. Germain, L. Muller, T. Jowitt, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Order within disorder: Aggrecan chondroitin sulphate-attachment region provides new structural insights into protein sequences classified as disordered

T. Jowitt, T. Hardingham, A. Murdoch, 2010, Proteins.

Tropoelastin is a Flexible Molecule that Retains its Canonical Shape.

A. Tarakanova, M. Buehler, A. Weiss, 2018, Macromolecular bioscience.

Targeted Modulation of Tropoelastin Structure and Assembly

A. Weiss, C. Baldock, Giselle C. Yeo, 2016, ACS biomaterials science & engineering.

Internal cleavage and synergy with twisted gastrulation enhance BMP inhibition by BMPER

Michael P. Lockhart-Cairns, C. Baldock, A. Godwin, 2019, Matrix biology : journal of the International Society for Matrix Biology.

Heterogeneity of Collagen VI Microfibrils

M. Paulsson, C. Baldock, P. Bonaldo, 2016, The Journal of Biological Chemistry.

Structural characterization of twisted gastrulation provides insights into opposing functions on the BMP signalling pathway

T. Jowitt, Michael P. Lockhart-Cairns, C. Baldock, 2016, Matrix biology : journal of the International Society for Matrix Biology.

Defining Elastic Fiber Interactions by Molecular Fishing

A. Shuttleworth, C. Baldock, A. McGovern, 2009, Molecular & Cellular Proteomics.

Elastic Fibre Proteins in Elastogenesis and Wound Healing

A. Roseman, T. Jowitt, C. Baldock, 2022, International journal of molecular sciences.

Fibulin 5 Forms a Compact Dimer in Physiological Solutions

Richard P. O. Jones, T. Jowitt, C. Baldock, 2009, The Journal of Biological Chemistry.

Autosomal Recessive Cutis Laxa 1C Mutations Disrupt the Structure and Interactions of Latent TGFβ Binding Protein-4

T. Jowitt, Michael P. Lockhart-Cairns, A. Weiss, 2021, Frontiers in Genetics.

ADAMTS10-mediated tissue disruption in Weill–Marchesani syndrome

R. Boot-Handford, C. Baldock, A. Godwin, 2018, Human molecular genetics.

Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development

Daniel R. Martin, C. Baldock, C. Lo, 2021, bioRxiv.

Structural and functional evidence for a substrate exclusion mechanism in mammalian tolloid like-1 (TLL-1) proteinase

K. Kadler, T. Jowitt, C. Baldock, 2010, FEBS letters.

Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid

R. Kammerer, K. Kadler, T. Jowitt, 2009, Proceedings of the National Academy of Sciences.

Multiscale Imaging Reveals the Hierarchical Organization of Fibrillin Microfibrils

David J. Smith, A. Roseman, C. Baldock, 2018, Journal of molecular biology.

Fibrillin-1 Mutations Causing Weill-Marchesani Syndrome and Acromicric and Geleophysic Dysplasias Disrupt Heparan Sulfate Interactions

C. Baldock, A. McGovern, C. Kielty, 2012, PloS one.

Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory latent TGFβ-binding site

A. Roseman, J. Thomson, C. Baldock, 2022, bioRxiv.

Modelling the structure of Short Gastrulation and generation of a toolkit for studying its function in Drosophila

H. Ashe, C. Baldock, Catherine Sutcliffe, 2022, bioRxiv.

Diversity between mammalian tolloid proteinases: Oligomerisation and non-catalytic domains influence activity and specificity

L. Bird, T. Jowitt, C. Baldock, 2016, Scientific Reports.

The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity

T. Jowitt, C. Baldock, R. Collins, 2015, Biochemical Society transactions.

Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation.

J. Enghild, T. Jowitt, C. Baldock, 2020, The Journal of biological chemistry.

Microsoft Word-Briggs et al. 19 February 2020_revised.docx

J. Enghild, T. Jowitt, C. Baldock, 2020 .

Tissue specific differences in fibrillin microfibrils analysed using single particle image analysis.

C. Baldock, M. Sherratt, Yinhui Lu, 2006, Journal of structural biology.

ADAMTS6 cleaves the large latent TGFβ complex and increases the mechanotension of cells to activate TGFβ.

Steven Woods, S. Kimber, C. Baldock, 2022, Matrix biology : journal of the International Society for Matrix Biology.

Fibrillin microfibrils: a key role for the interbead region in elasticity.

C. Baldock, Yinhui Lu, Ming-chuan Wang, 2009, Journal of molecular biology.

Fibrillin microfibrils.

C. Baldock, C. Kielty, M. Sherratt, 2005, Advances in protein chemistry.

Organization and biomechanical properties of fibrillin microfibrils

C. Baldock, C. Kielty, M. Sherratt, 2004 .

Raman Microscopy and X-ray Diffraction, a Combined Study of Fibrillin-rich Microfibrillar Elasticity*

S. Engelsen, M. Roessle, C. Baldock, 2003, Journal of Biological Chemistry.

The C-terminal dimerization domain of the respiratory mucin MUC5B functions in mucin stability and intracellular packaging before secretion

T. Jowitt, Michael P. Lockhart-Cairns, C. Baldock, 2019, The Journal of Biological Chemistry.

Assembly of the Respiratory Mucin MUC5B

T. Jowitt, T. Hardingham, B. Raynal, 2014, The Journal of Biological Chemistry.

Three-dimensional reconstructions of extracellular matrix polymers using automated electron tomography.

A. Koster, K. Kadler, C. Baldock, 2002, Journal of structural biology.

The morphology of adsorbed extracellular matrix assemblies is critically dependent on solution calcium concentration.

C. Baldock, C. Kielty, M. Sherratt, 2007, Matrix biology : journal of the International Society for Matrix Biology.

Collagen VI, Conformation of A-domain Arrays and Microfibril Architecture

R. Kammerer, A. Roseman, T. Jowitt, 2011, The Journal of Biological Chemistry.

Mutation of the gene encoding fibrillin-2 results in syndactyly in mice.

K. Steel, M. Dixon, C. Baldock, 2001, Human molecular genetics.

The Role of the C1 and C2 A-domains in Type VI Collagen Assembly*

C. Baldock, C. Kielty, C. Shuttleworth, 2001, The Journal of Biological Chemistry.

A potential role for endogenous proteins as sacrificial sunscreens and antioxidants in human tissues

N. Gibbs, A. Weiss, C. Baldock, 2015, Redox biology.

Mechanism of action of diazaborines.

D W Rice, D. Rice, J. Rafferty, 1998, Biochemical pharmacology.

A Mechanism of Drug Action Revealed by Structural Studies of Enoyl Reductase

Antoni R. Slabas, Clair Baldock, David W. Rice, 1996, Science.

A study of the structure-activity relationship for diazaborine inhibition of Escherichia coli enoyl-ACP reductase.

D W Rice, D. Rice, J. Rafferty, 2001, Journal of molecular biology.

The X-ray structure of Escherichia coli enoyl reductase with bound NAD+ at 2.1 A resolution.

D. Rice, J. Rafferty, C. Baldock, 1998, Journal of molecular biology.

Molecular genetic analysis of enoyl‐acyl carrier protein reductase inhibition by diazaborine

D. Rice, J. Rafferty, C. Baldock, 1999, Molecular microbiology.

The Cryo-EM structure of the CorA channel from Methanocaldococcus jannaschii in low magnesium conditions

J. Derrick, C. A. Shintre, C. Baldock, 2015, Biochimica et biophysica acta.

Collagens at a glance

Clair Baldock, Jordi Bella, Karl E Kadler, 2007, Journal of Cell Science.

Tropoelastin Implants That Accelerate Wound Repair

Alan Riboldi-Tunnicliffe, Clair Baldock, Anthony S Weiss, 2018, Advanced healthcare materials.

Common themes in redox chemistry emerge from the X-ray structure of oilseed rape (Brassica napus) enoyl acyl carrier protein reductase.

P J Artymiuk, D W Rice, J W Simon, 1995, Structure.

Crystallization and preliminary X-ray crystallographic studies on acyl-(acyl carrier protein) from Escherichia coli.

D. Rice, P. Baker, J. Rafferty, 2002, Acta crystallographica. Section D, Biological crystallography.

Determination of the X-Ray Crystallographic Structure of E.coli Butyryl-ACP

D. Rice, P. Baker, J. Rafferty, 2003 .

Structural and compositional diversity of fibrillin microfibrils in human tissues

C. Baldock, C. Griffiths, R. E. Watson, 2018, The Journal of Biological Chemistry.

X-ray crystallographic studies on butyryl-ACP reveal flexibility of the structure around a putative acyl chain binding site.

D. Rice, P. Baker, J. Rafferty, 2002, Structure.

Transglutaminase mediated asprosin oligomerization allows its tissue storage as fibers

M. Odenthal, T. Jowitt, M. Paulsson, 2022, bioRxiv.

The role of fibrillin and microfibril binding proteins in elastin and elastic fibre assembly

Michael P. Lockhart-Cairns, C. Baldock, S. Cain, 2019, Matrix biology : journal of the International Society for Matrix Biology.

The supramolecular organization of collagen VI microfibrils.

C. Baldock, C. Kielty, M. Sherratt, 2003, Journal of molecular biology.

Structural studies of elastic fibre and microfibrillar proteins

C. Baldock, Mukti Singh, M. Becker, 2021, Matrix biology plus.

Defining the hierarchical organisation of collagen VI microfibrils at nanometre to micrometre length scales

A. Roseman, C. Baldock, M. Sherratt, 2017, Acta biomaterialia.

Corneal collagen fibril structure in three dimensions: Structural insights into fibril assembly, mechanical properties, and tissue organization

U Ziese, A J Koster, K. Kadler, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Stem cell patenting

C. Baldock, 2006 .

The molecular genetics of Marfan syndrome and related disorders

P. Robinson, D. Milewicz, D. Judge, 2006, Journal of Medical Genetics.

Tropoelastin and Elastin Assembly

A. Tarakanova, A. Weiss, C. Baldock, 2021, Frontiers in Bioengineering and Biotechnology.

Fibrillin-1 Interactions with Heparin

Clair Baldock, Anthony S Weiss, A. Weiss, 2005, Journal of Biological Chemistry.

Homotypic Fibrillin-1 Interactions in Microfibril Assembly*

Clair Baldock, C. Baldock, M. Rock, 2005, Journal of Biological Chemistry.

Marfan Syndrome-causing Mutations in Fibrillin-1 Result in Gross Morphological Alterations and Highlight the Structural Importance of the Second Hybrid Domain*

Clair Baldock, T. Jowitt, B. Raynal, 2006, Journal of Biological Chemistry.

Delineation of a new fibrillin-2-opathy with evidence for a role of FBN2 in the pathogenesis of carpal tunnel syndrome

G. Mortier, C. Baldock, E. Fransen, 2020, Journal of Medical Genetics.

Secreted ADAMTS-like 2 promotes myoblast differentiation by potentiating Wnt signaling

C. Baldock, Nandaraj Taye, D. Hubmacher, 2022, bioRxiv.

Missense mutations that cause Van der Woude syndrome and popliteal pterygium syndrome affect the DNA-binding and transcriptional activation functions of IRF6

T. Jowitt, M. Dixon, C. Baldock, 2008, Human molecular genetics.

BMP antagonists in tissue development and disease

C. Baldock, G. Sengle, Laura-Marie A. Zimmermann, 2021, Matrix biology plus.

Structural effects of fibulin 5 missense mutations associated with age-related macular degeneration and cutis laxa.

Richard P. O. Jones, T. Jowitt, C. Baldock, 2010, Investigative ophthalmology & visual science.

A new MMP‐mediated prodomain cleavage mechanism to activate bone morphogenetic proteins from the extracellular matrix

C. Baldock, M. Koch, A. Wohl, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mammalian tolloid proteinases: role in growth factor signalling

T. Jowitt, Michael P. Lockhart-Cairns, C. Baldock, 2016, FEBS letters.

Tropoelastin bridge region positions the cell-interactive C terminus and contributes to elastic fiber assembly

Manfred Roessle, Giselle C Yeo, Clair Baldock, 2012, Proceedings of the National Academy of Sciences.

The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function

L. Tabernero, A. Mould, T. Jowitt, 2017, Scientific Reports.

A turning point in elastin structure

A. Weiss, C. Baldock, D. Lammie, 2006 .

Synthetic enzyme-substrate tethering obviates the Tolloid-ECM interaction during Drosophila BMP gradient formation

H. Ashe, C. Baldock, A. Sawala, 2015, eLife.

Nanoscale structure of the BMP antagonist chordin supports cooperative BMP binding

T. Jowitt, C. Baldock, R. Collins, 2014, Proceedings of the National Academy of Sciences.

How the dual PDZ domain from Postsynaptic density protein 95 clusters ion channels and receptors

J. Chipperfield, L. Bird, Michael P. Lockhart-Cairns, 2019, bioRxiv.

Missense mutations in the β strands of the single A-domain of matrilin-3 result in multiple epiphyseal dysplasia

O. Mäkitie, G. Mortier, L. Ala‐Kokko, 2004, Journal of Medical Genetics.

Collagen VI Microfibril Formation Is Abolished by an α2(VI) von Willebrand Factor Type A Domain Mutation in a Patient with Ullrich Congenital Muscular Dystrophy*

K. North, C. Baldock, J. Bateman, 2010, The Journal of Biological Chemistry.

Structural correlation between collagen VI microfibrils and collagen VI banded aggregates.

Peter M. G. Munro, J. Squire, C. Baldock, 2006, Journal of structural biology.

Coarse-Grained Modeling of Antibodies from Small-Angle Scattering Profiles.

C. F. van der Walle, S. Uddin, C. Avendaño, 2017, The journal of physical chemistry. B.

Missense mutations in the b strands of the single A-domain of matrilin-3 result in multiple epiphyseal dysplasia

O. Mäkitie, G. Mortier, L. Ala‐Kokko, 2004 .

Reprint of "Structural correlation between collagen VI microfibrils and collagen VI banded aggregates" [J. Struct. Biol. 154 (2006) 312-326].

Peter M. G. Munro, J. Squire, C. Baldock, 2006, Journal of Structural Biology.

Fibrillin microfibrils are stiff reinforcing fibres in compliant tissues.

Clair Baldock, Michael J Sherratt, C. Baldock, 2003, Journal of molecular biology.

Subtle balance of tropoelastin molecular shape and flexibility regulates dynamics and hierarchical assembly

Markus J Buehler, Giselle C Yeo, Anna Tarakanova, 2016, Science Advances.

The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function

L. Tabernero, A. Mould, T. Jowitt, 2017, Scientific Reports.

Molecular architecture of the tyrosine phosphatase HD-PTP and the structural basis for its specific interaction with UBAP1

Bella, L. Tabernero, T. Jowitt, 2018 .

A Negatively Charged Residue Stabilizes the Tropoelastin N-terminal Region for Elastic Fiber Assembly

A. Weiss, C. Baldock, Giselle C. Yeo, 2014, The Journal of Biological Chemistry.

Domains 17-27 of tropoelastin contain key regions of contact for coacervation and contain an unusual turn-containing crosslinking domain.

A. Weiss, C. Baldock, D. Lammie, 2007, Matrix biology : journal of the International Society for Matrix Biology.

The Supramolecular Organization of Fibrillin-Rich Microfibrils

A. Koster, K. Kadler, C. Baldock, 2001, The Journal of cell biology.

Cooperative folding of intrinsically disordered domains drives assembly of a strong elongated protein

Herman K. H. Fung, E. Paci, J. Clarke, 2015, Nature Communications.

Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch

T. Jowitt, Michael P. Lockhart-Cairns, C. Baldock, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Unraveling the Mechanism of Procollagen C-Proteinase Enhancer.

Michael P. Lockhart-Cairns, C. Baldock, 2018, Structure.

Functional role of A-domains in type VI collagen.

A. Shuttleworth, C. Baldock, C. Kielty, 1999, Biochemical Society transactions.

Fibrillin: from microfibril assembly to biomechanical function.

Clair Baldock, C. Baldock, M. Rock, 2002, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Cadherin flexibility provides a key difference between desmosomes and adherens junctions

L. Tabernero, T. Jowitt, C. Baldock, 2015, Proceedings of the National Academy of Sciences.

Intellectual property protection for plant-related inventions in Europe

Barbara Fleck, C. Baldock, Claire Baldock, 2003, Nature Reviews Genetics.

Evidence for the intramolecular pleating model of fibrillin microfibril organisation from single particle image analysis.

C. Baldock, Yinhui Lu, D. Holmes, 2005, Journal of molecular biology.

Collagen VI Microfibril Formation Is Abolished by an α2(VI) von Willebrand Factor Type A Domain Mutation in a Patient with Ullrich Congenital Muscular Dystrophy*

K. North, C. Baldock, J. Bateman, 2010, The Journal of Biological Chemistry.

The molecular genetics of Marfan syndrome and related disorders

D. Milewicz, D. Judge, H. Dietz, 2006, Journal of Medical Genetics.

Structural and compositional diversity of fibrillin microfibrils in human tissues

C. Baldock, C. Griffiths, M. Sherratt, 2018, The Journal of Biological Chemistry.

Lysyl oxidase–like 2 (LOXL2)–mediated cross-linking of tropoelastin

S. Germain, L. Muller, T. Jowitt, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix

T. Jowitt, Michael P. Lockhart-Cairns, C. Baldock, 2024, bioRxiv.

Erratum: Missense mutations that cause Van der Woude syndrome and popliteal pterygium syndrome affect the DNA-binding and transcriptional activation functions of IRF6 (Human Molecular Genetics (2009) vol. 18(3) (535-545) 10.1093/hmg/ddn381)

T. Jowitt, M. Dixon, C. Baldock, 2009 .

Molecular mechanism of BMP signal control by Twisted gastrulation

H. Ashe, C. Siebold, C. Baldock, 2024, Nature communications.