J. Pascal

发表

An atypical BRCT–BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex

J. Tainer, A. Tomkinson, M. Hammel, 2020, Nucleic acids research.

Human DNA ligase I completely encircles and partially unwinds nicked DNA

A. Tomkinson, T. Ellenberger, J. Pascal, 2004, Nature.

The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1.

A. Tomkinson, T. Ellenberger, J. Pascal, 2009, DNA repair.

A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA.

John A Tainer, Greg L. Hura, Alan E Tomkinson, 2006, Molecular cell.

Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1

J. Pascal, Ji-Chun Yang, D. Neuhaus, 2015, Molecular cell.

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks

Ilya J. Finkelstein, Marie-christine Caron, J. Masson, 2019, Nature Communications.

Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity.

Alan Ashworth, Bhargav A. Patel, A. Ashworth, 2019, Journal of medicinal chemistry.

Structural Basis for DNA Damage–Dependent Poly(ADP-ribosyl)ation by Human PARP-1

J. Pascal, M. Langelier, J. Planck, 2012, Science.

PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1

J. Pascal, M. Langelier, A. Riccio, 2014, Nucleic acids research.

Identification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channels

R. Armen, J. Pascal, Miao Zhang, 2012, Nature Communications.

The comings and goings of PARP-1 in response to DNA damage.

J. Pascal, 2018, DNA repair.

Evaluating Parp1 domains as gossypol targets

J. Pascal, V. Studitsky, N. Maluchenko, 2016, Moscow University Biological Sciences Bulletin.

Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA

J. Pascal, M. Langelier, J. Planck, 2011, The Journal of Biological Chemistry.

The Zn3 Domain of Human Poly(ADP-ribose) Polymerase-1 (PARP-1) Functions in Both DNA-dependent Poly(ADP-ribose) Synthesis Activity and Chromatin Compaction*

J. Pascal, W. Kraus, M. Langelier, 2010, The Journal of Biological Chemistry.

A Third Zinc-binding Domain of Human Poly(ADP-ribose) Polymerase-1 Coordinates DNA-dependent Enzyme Activation*

J. Pascal, E. Rogers, M. Langelier, 2008, Journal of Biological Chemistry.

Structural Implications for Selective Targeting of PARPs

R. Armen, J. Pascal, J. Brody, 2013, Front. Oncol..

PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification.

J. Pascal, M. Langelier, A. Riccio, 2018, Current opinion in structural biology.

Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.

J. Pascal, Kushol Gupta, G. V. Van Duyne, 2016, Structure.

PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis.

J. Pascal, M. Langelier, 2013, Current opinion in structural biology.

Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo.

F. Robert, B. Pugh, J. Pascal, 2016, Molecular cell.

The rise and fall of poly(ADP-ribose): An enzymatic perspective.

T. Ellenberger, J. Pascal, 2015, DNA Repair.

Crystal structures and functional analysis of the ZnF5-WWE1-WWE2 region of PARP13/ZAP define a new mode of engaging poly(ADP-ribose)

J. Pascal, H. Soufari, A. Leung, 2021, bioRxiv.

Human DNA ligases I, III, and IV-purification and new specific assays for these enzymes.

X. Chen, G. M. Wilson, A. Tomkinson, 2006, Methods in enzymology.

Signal-induced PARP1-Erk synergism mediates IEG expression

J. Pascal, M. Cohen-Armon, A. Yeheskel, 2019, Signal Transduction and Targeted Therapy.

A PARP1-ERK2 synergism is required for the induction of LTP

M. Segal, H. Milshtein-Parush, I. Slutsky, 2016, Scientific Reports.

Structural basis for allosteric PARP-1 retention on DNA breaks

S. Pettitt, C. Lord, B. E. Black, 2020, Science.

New players to the field of ADP‐ribosylation make the final cut

J. Pascal, J. Steffen, 2013, The EMBO journal.

ADP-ribosyltransferases, an update on function and nomenclature

A. Ashworth, D. Corda, I. Matic, 2021, The FEBS journal.

Hydrofluoric Acid-Based Derivatization Strategy To Profile PARP-1 ADP-Ribosylation by LC-MS/MS.

J. Gagné, G. Poirier, J. Pascal, 2018, Journal of proteome research.

Structure and activity of an active site substitution of ricin A chain.

J. Pascal, A. Frankel, A. Monzingo, 1996, Biochemistry.

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo

S. Zha, J. Pascal, Zhengping Shao, 2020, Nucleic acids research.

Human PARP1 Facilitates Transcription through a Nucleosome and Histone Displacement by Pol II In Vitro

J. Pascal, V. Studitsky, A. Feofanov, 2022, International journal of molecular sciences.

The Smc5/6 Core Complex Is a Structure-Specific DNA Binding and Compacting Machine.

J. Marko, A. Sverzhinsky, J. Pascal, 2020, Molecular cell.

A two-step mechanism governing PARP1-DNA retention by PARP inhibitors

A. Bhardwaj, J. Pascal, E. Rothenberg, 2022, Science advances.

Tankyrase SAM domain polymerization is required for its role in Wnt signaling

J. Pascal, M. Langelier, A. Riccio, 2016 .

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM

T. Helleday, J. Pascal, O. Mortusewicz, 2022, bioRxiv.

Unorthodox PCNA Binding by Chromatin Assembly Factor 1

E. Laue, K. Borden, J. Omichinski, 2022, International journal of molecular sciences.

Purification of DNA Damage-Dependent PARPs from E. coli for Structural and Biochemical Analysis.

J. Pascal, M. Langelier, A. Riccio, 2017, Methods in molecular biology.

Abstract IA9: Cross talk of the androgen receptor and DNA damage pathways: Molecular and translational prostate cancer relevance

A. Chinnaiyan, F. Feng, A. Dicker, 2012 .

Poly(ADP-ribose) polymerase enzymes and the maintenance of genome integrity

J. Pascal, T. Eisemann, 2019, Cellular and Molecular Life Sciences.

Purification of human PARP-1 and PARP-1 domains from Escherichia coli for structural and biochemical analysis.

J. Pascal, M. Langelier, J. Planck, 2011, Methods in molecular biology.

Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.

A. Shelat, J. Pascal, I. T. Kirby, 2022, Cell chemical biology.

Clinical PARP inhibitors allosterically induce PARP2 retention on DNA

S. Zha, J. Pascal, M. Langelier, 2022, bioRxiv.

Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose 4,6-dehydratase

J. Pascal, M. Langelier, T. Eisemann, 2019, The Journal of Biological Chemistry.

Mechanisms of Nucleosome Reorganization by PARP1

Md. Sohail Akhtar, M. Kirpichnikov, J. Pascal, 2021, International Journal of Molecular Sciences.

Unfolding of core nucleosomes by PARP-1 revealed by spFRET microscopy

M. Kirpichnikov, J. Pascal, V. Studitsky, 2017, AIMS Genetics.

Crystal structures and functional analysis of the ZnF5-WWE1-WWE2 region of PARP13/ZAP define a distinctive mode of engaging poly(ADP-ribose)

J. Pascal, H. Soufari, A. Leung, 2022, Cell reports.

PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain.

Jamin D Steffen, B. E. Black, J. Pascal, 2015, Molecular cell.

Discovery and Structure–Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors

Frank R. Fronczek, Yves Pommier, Junko Murai, 2014, Journal of medicinal chemistry.

The nucleosomal surface is the main target of histone ADP-ribosylation in response to DNA damage.

B. Garcia, J. Pascal, K. Karch, 2017, Molecular bioSystems.

Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity

Roger S. Armen, Joseph Y. Cheung, Xue Li, 2011, Proceedings of the National Academy of Sciences.

Dual roles of PARP-1 promote cancer growth and progression.

A. Chinnaiyan, F. Feng, G. Raj, 2012, Cancer discovery.

Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling

J. Pascal, H. Schüler, T. Karlberg, 2013, Molecular Aspects of Medicine.

DNA and RNA ligases: structural variations and shared mechanisms.

J. Pascal, 2008, Current opinion in structural biology.

DNA ligases: structure, reaction mechanism, and function.

A. Tomkinson, T. Ellenberger, J. Pascal, 2006, Chemical reviews.

2.8‐Å crystal structure of a nontoxic type‐II ribosome‐inactivating protein, ebulin l

J. Pascal, A. Monzingo, J. Robertus, 2001, Proteins.

Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.

L. Lum, D. Finkelstein, D. Strand, 2020, Cell reports.

DNA ligases: structure, reaction mechanism, and function.

A. Tomkinson, T. Ellenberger, J. Pascal, 2006, Chemical reviews.

Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors.

C. Yeo, M. Pishvaian, J. Pascal, 2017, Cancer research.

Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response.

R. Armen, U. Rodeck, J. Pascal, 2015, The Biochemical journal.

Autoregulation of kinase dephosphorylation by ATP binding in AGC protein kinases

R. Armen, U. Rodeck, J. Pascal, 2012, Cell cycle.

Crystal structure of TB-RBP, a novel RNA-binding and regulating protein.

P. Hart, J. Pascal, J. Robertus, 2002, Journal of molecular biology.

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation

Y. Pommier, L. Jenkins, J. Pascal, 2021, Nature Communications.

Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases.

J. Sanders, J. Pascal, Cuiping Liu, 2012, RNA.

PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage

J. Pascal, G. Cingolani, A. Riccio, 2015, Nucleic acids research.

PARP1 associates with R-loops to promote their resolution and genome stability

J. Masson, G. Poirier, J. Pascal, 2023, Nucleic acids research.

Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation.

A. Tomkinson, A. Sverzhinsky, J. Pascal, 2020, Journal of molecular biology.

NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains

B. E. Black, J. Pascal, Levani Zandarashvili, 2018, Nature Communications.

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications

B. E. Black, A. Sverzhinsky, J. Pascal, 2021, Nature Communications.

Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs.

D. Figeys, L. Foster, Zhibin Ning, 2015, DNA repair.

Tankyrase interacts with the allosteric site of glucokinase and inhibits its glucose-sensing function in the beta cell

J. Pascal, Tsung-Yin J. Yeh, O. Osborn, 2021, bioRxiv.

Mouse testis-brain RNA-binding protein (TB-RBP): expression, purification and crystal X-ray diffraction.

J. Pascal, V. Chennathukuzhi, J. Robertus, 2001, Acta Crystallographica Section D: Biological Crystallography.

Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex.

J. Pascal, D. Logothetis, Xuanyu Meng, 2014, Nature chemical biology.

Supplemental Information Structural Basis for Calmodulin as a Dynamic Calcium Sensor

P. Loll, Liping He, C. Abrams, 2012 .

NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains

B. E. Black, J. Pascal, Marie-France Langelier, 2018, Nature Communications.

Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus

J. Tainer, A. Tomkinson, M. Hammel, 2021, The Journal of biological chemistry.

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition

J. Pascal, Ji-Chun Yang, D. Neuhaus, 2020, bioRxiv.

CARM1 regulates replication fork speed and stress response by stimulating PARP1.

J. Gagné, G. Poirier, I. Ahel, 2020, Molecular cell.

Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations

Marie-Ève Picard, M. Manenda, R. Shi, 2020, The Journal of Biological Chemistry.

Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation

J. Pascal, Miao Zhang, Ji-fang Zhang, 2013, Proceedings of the National Academy of Sciences.

Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase.

A. Tomkinson, A. Sverzhinsky, J. Pascal, 2021, Structure.

DNA Ligases: Structures

J. Pascal, 2013 .

Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

Jamin D Steffen, C. Yeo, J. Pascal, 2014, Cancer research.

Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.

S. Pettitt, C. Lord, J. Pascal, 2022, Molecular cell.

Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage

J. Pascal, Michael McCauley, J. Steffen, 2016, Nucleic acids research.

Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signaling.

J. Pascal, M. Langelier, A. Riccio, 2016, Structure.

PARP-nucleic acid interactions: Allosteric signaling, PARP inhibitor types, DNA bridges, and viral RNA surveillance.

J. Pascal, 2023, Current opinion in structural biology.

Bridging a DNA Break to Leave a Poly(ADP-Ribose) Mark on Chromatin.

J. Pascal, Élise Rouleau-Turcotte, 2020, Molecular cell.

RNA ligase does the AMP shuffle

T. Ellenberger, J. Pascal, 2006, Nature Structural &Molecular Biology.

Evaluating Parp1 domains as gossypol targets

J. Pascal, N. Maluchenko, E. Kotova, 2016, Moscow University Biological Sciences Bulletin.

Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity

Xia Li, J. Cheung, R. Armen, 2011, Proceedings of the National Academy of Sciences.

Poly(ADP-ribose) polymerase enzymes and the maintenance of genome integrity

J. Pascal, T. Eisemann, 2019, Cellular and Molecular Life Sciences.

The rise and fall of poly(ADP-ribose): An enzymatic perspective.

T. Ellenberger, J. Pascal, 2015, DNA repair.

Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1

J. Pascal, Ji-Chun Yang, D. Neuhaus, 2015, Molecular cell.

Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP

J. Pascal, Léonie Frigon, 2023, Nucleic acids research.

ADP-ribose contributions to genome stability and PARP enzyme trapping on sites of DNA damage; paradigm shifts for a coming-of-age modification

J. Pascal, Élise Rouleau-Turcotte, 2023, The Journal of biological chemistry.

The nucleosomal surface is the main target of histone ADP-ribosylation in response to DNA damage.

B. Garcia, J. Pascal, Kelly R Karch, 2017, Molecular bioSystems.