N. Artemyev

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Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor

D. Srivastava, L. Gakhar, N. Artemyev, 2019, Nature Communications.

MBP-fusion protein of transducin-alpha residues 327-350

D. Srivastava, L. Gakhar, N. Artemyev, 2019 .

Extended conformation of the proline‐rich domain of human aryl hydrocarbon receptor‐interacting protein‐like 1: implications for retina disease

L. Gakhar, N. Artemyev, R. Yadav, 2015, Journal of neurochemistry.

The Trimeric GTP-binding Protein (Gq/G11) α Subunit Is Required for Insulin-stimulated GLUT4 Translocation in 3T3L1 Adipocytes*

M. Kanzaki, R. Watson, N. Artemyev, 2000, The Journal of Biological Chemistry.

A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene

S. Bolz, B. Jurklies, J. Heckenlively, 2009, Proceedings of the National Academy of Sciences.

Decreased catalytic activity and altered activation properties of PDE6C mutants associated with autosomal recessive achromatopsia.

E. Zrenner, T. Rosenberg, B. Jurklies, 2011, Human molecular genetics.

Interaction of Aryl Hydrocarbon Receptor-interacting Protein-like 1 with the Farnesyl Moiety*

L. Gakhar, N. Artemyev, A. Majumder, 2013, The Journal of Biological Chemistry.

Mutational Analysis of the Asn Residue Essential for RGS Protein Binding to G-proteins*

N. Artemyev, R. McEntaffer, M. Natochin, 1998, The Journal of Biological Chemistry.

Transducin Partners Outside the Phototransduction Pathway

Shivangi M. Inamdar, M. Sokolov, D. Srivastava, 2020, Frontiers in Cellular Neuroscience.

Expression and subcellular distribution of UNC119a, a protein partner of transducin α subunit in rod photoreceptors.

M. Sokolov, N. Artemyev, A. Majumder, 2013, Cellular signalling.

Large-scale conformational rearrangement of the α5-helix of Gα subunits in complex with the guanine nucleotide exchange factor Ric8A

D. Srivastava, N. Artemyev, 2019, The Journal of Biological Chemistry.

Probing rhodopsin–transducin interaction using Drosophila Rh1–bovine rhodopsin chimeras

N. Artemyev, M. Natochin, J. O'Tousa, 2006, Vision Research.

The Inhibitory γ Subunit of the Rod cGMP Phosphodiesterase Binds the Catalytic Subunits in an Extended Linear Structure*

N. Artemyev, A. Hajipour, Lian‐Wang Guo, 2006, Journal of Biological Chemistry.

A single mutation Asp229 --> Ser confers upon Gs alpha the ability to interact with regulators of G protein signaling.

N. Artemyev, M. Natochin, 1998, Biochemistry.

Photophobia and abnormally sustained pupil responses in a mouse model of bradyopsia.

R. Kardon, N. Artemyev, A. Russo, 2014, Investigative ophthalmology & visual science.

Molecular insights into the maturation of phosphodiesterase 6 by the specialized chaperone complex of HSP90 with AIPL1

N. Artemyev, R. Yadav, Kimberly K. Boyd, 2022, The Journal of biological chemistry.

Rhodopsin Recognition by Mutant Gsα Containing C-terminal Residues of Transducin*

N. Artemyev, R. McEntaffer, M. Natochin, 2000, The Journal of Biological Chemistry.

Mechanisms of dominant negative G‐protein α subunits

N. Artemyev, Brandy Barren, 2007 .

Dominant Negative Mutants of Transducin-α That Block Activated Receptor†

N. Artemyev, M. Natochin, Brandy Barren, 2006 .

Heterologous expression of bovine rhodopsin in Drosophila photoreceptor cells.

N. Artemyev, M. Natochin, J. O'Tousa, 2006, Investigative ophthalmology & visual science.

A Truncated Form of Rod Photoreceptor PDE6 β-Subunit Causes Autosomal Dominant Congenital Stationary Night Blindness by Interfering with the Inhibitory Activity of the γ-Subunit

N. Artemyev, A. Majumder, P. Brabet, 2014, PloS one.

A GPR-protein interaction surface of Gi(alpha): implications for the mechanism of GDP-release inhibition.

N. Artemyev, M. Natochin, K. Gasimov, 2002, Biochemistry.

Frmpd1 Facilitates Trafficking of G-Protein Transducin and Modulates Synaptic Function in Rod Photoreceptors of Mammalian Retina

Jayshree Advani, A. Swaroop, D. Srivastava, 2022, eNeuro.

Rod phosphodiesterase-6 PDE6A and PDE6B Subunits Are Enzymatically Equivalent*

N. Artemyev, Kimberly K. Boyd, H. Muradov, 2010, The Journal of Biological Chemistry.

Active sites of the cyclic GMP phosphodiesterase γ‐subunit of retinal rod outer segments

N. Artemyev, V. Lipkin, I. Dumler, 1988 .

Microsoft Word-155936_1_art_file_404643_pyr738-corr2.docx

D. Srivastava, N. Artemyev, 2019 .

Roles of the transducin alpha-subunit alpha4-helix/alpha4-beta6 loop in the receptor and effector interactions.

N. Artemyev, M. Natochin, A. Granovsky, 1999, The Journal of biological chemistry.

Interactions between catalytic and inhibitory subunits of PDE6.

N. Artemyev, 2005, Methods in molecular biology.

Assays of G protein/cGMP-phosphodiesterase interactions.

N. Artemyev, A. Granovsky, 2002, Methods in enzymology.

[42] Inhibition of photoreceptor cGMP phosphodiesterase by its γ subunit

N. Artemyev, A. Granovsky, K. Muradov, 2000 .

Potency and mechanism of action of E4021, a type 5 phosphodiesterase isozyme-selective inhibitor, on the photoreceptor phosphodiesterase depend on the state of activation of the enzyme.

N. Artemyev, M. D'Amours, R. Cote, 1999, Molecular pharmacology.

An Effector Site That Stimulates G-protein GTPase in Photoreceptors (*)

H. Hamm, V. Arshavsky, J. Sondek, 1995, The Journal of Biological Chemistry.

Photoreceptor phosphodiesterase: interaction of inhibitory gamma subunit and cyclic GMP with specific binding sites on catalytic subunits.

V. Arshavsky, N. Artemyev, R. Cote, 1998, Methods.

N-Terminal Fatty Acylation of Transducin Profoundly Influences Its Localization and the Kinetics of Photoresponse in Rods

W. W. Rubin, N. Artemyev, M. E. Burns, 2007, The Journal of Neuroscience.

Regulation of transducin GTPase activity in bovine rod outer segments.

H. Hamm, V. Arshavsky, N. Skiba, 1994, The Journal of biological chemistry.

Rhodopsin Determinants for Transducin Activation: A Gain-of-Function Approach

N. Artemyev, M. Natochin, K. Gasimov, 2003 .

Characterization of the Gαs Regulator Cysteine String Protein*

N. Artemyev, S. Hameed, M. Natochin, 2005, Journal of Biological Chemistry.

Analysis of dimerization determinants of PDE6 catalytic subunits.

N. Artemyev, Kimberly K. Boyd, K. Muradov, 2005, Methods in molecular biology.

Substitution of Transducin Ser202 by Asp Abolishes G-protein/RGS Interaction*

N. Artemyev, M. Natochin, 1998, The Journal of Biological Chemistry.

Regulation of Transducin GTPase Activity by Human Retinal RGS*

N. Artemyev, M. Natochin, A. Granovsky, 1997, The Journal of Biological Chemistry.

Characterization of Human Cone Phosphodiesterase-6 Ectopically Expressed in Xenopus laevis Rods*

N. Artemyev, M. Haeri, B. Knox, 2009, The Journal of Biological Chemistry.

Mechanisms of mutant PDE6 proteins underlying retinal diseases.

N. Artemyev, K. Gopalakrishna, Kimberly K. Boyd, 2017, Cellular signalling.

Distinct patterns of compartmentalization and proteolytic stability of PDE6C mutants linked to achromatopsia

N. Artemyev, A. Majumder, P. Cheguru, 2015, Molecular and Cellular Neuroscience.

Interaction of human retinal RGS with G‐protein α‐subunits

N. Artemyev, M. Natochin, V. Lipkin, 1997 .

Determinants for phosphodiesterase 6 inhibition by its gamma-subunit.

N. Artemyev, Zhongmin Zhang, 2010, Biochemistry.

Reproducibility of the Rod Photoreceptor Response Depends Critically on the Concentration of the Phosphodiesterase Effector Enzyme

G. Fain, Mingyao Liu, N. Artemyev, 2022, The Journal of Neuroscience.

The PDE6 mutation in the rd10 retinal degeneration mouse model causes protein mislocalization and instability and promotes cell death through increased ion influx

G. Fain, M. Woodruff, N. Artemyev, 2018, Journal of Biological Chemistry.

A site on transducin alpha-subunit of interaction with the polycationic region of cGMP phosphodiesterase inhibitory subunit.

H. Hamm, K. Schey, N. Artemyev, 1993, The Journal of biological chemistry.

Probing functional interfaces of rod PDE γ-subunit using scanning fluorescent labeling

N. Artemyev, R. McEntaffer, A. Granovsky, 2007, Cell Biochemistry and Biophysics.

Asymmetric Interaction between Rod Cyclic GMP Phosphodiesterase γ Subunits and αβ Subunits*

N. Artemyev, A. Hajipour, A. Ruoho, 2005, Journal of Biological Chemistry.

A site on rod G protein alpha subunit that mediates effector activation.

H. Hamm, N. Artemyev, H. Rarick, 1992, Science.

Direct interaction of the inhibitory gamma-subunit of Rod cGMP phosphodiesterase (PDE6) with the PDE6 GAFa domains.

K. Schey, N. Artemyev, A. Granovsky, 2002, Biochemistry.

A conformational switch in the inhibitory gamma-subunit of PDE6 upon enzyme activation by transducin.

N. Artemyev, A. Granovsky, 2001, Biochemistry.

Mechanism of photoreceptor cGMP phosphodiesterase inhibition by its gamma-subunits.

H. Hamm, M. Busman, K. Schey, 1996, Proceedings of the National Academy of Sciences of the United States of America.

The Carboxyl Terminus of the γ-Subunit of Rod cGMP Phosphodiesterase Contains Distinct Sites of Interaction with the Enzyme Catalytic Subunits and the α-Subunit of Transducin (*)

H. Hamm, N. Skiba, N. Artemyev, 1995, The Journal of Biological Chemistry.

Inhibition of GDP/GTP exchange on G alpha subunits by proteins containing G-protein regulatory motifs.

N. Artemyev, M. Natochin, K. Gasimov, 2001, Biochemistry.

Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod Photoreceptors Mimics in Part Features of Light Adaptation

N. Artemyev, A. Majumder, A. Sampath, 2015, The Journal of Neuroscience.

The γ Subunit of Rod cGMP-Phosphodiesterase Blocks the Enzyme Catalytic Site*

N. Artemyev, M. Natochin, A. Granovsky, 1997, The Journal of Biological Chemistry.

An Interface of Interaction between Photoreceptor cGMP Phosphodiesterase Catalytic Subunits and Inhibitory γ Subunits*

N. Artemyev, M. Natochin, Michael Natochin, 1996, The Journal of Biological Chemistry.

Comparative analysis of cone and rod transducins using chimeric Gα subunits.

N. Artemyev, K. Gopalakrishna, Kimberly K. Boyd, 2012, Biochemistry.

Interaction of Transducin with Uncoordinated 119 Protein (UNC119)

N. Artemyev, K. Martemyanov, I. Masuho, 2011, The Journal of Biological Chemistry.

A point mutation uncouples transducin‐α from the photoreceptor RGS and effector proteins

N. Artemyev, M. Natochin, 2003 .

Probing the mechanism of rhodopsin-catalyzed transducin activation.

M. Moussaif, N. Artemyev, M. Natochin, 2001 .

Probing the mechanism of rhodopsin‐catalyzed transducin activation

M. Moussaif, N. Artemyev, M. Natochin, 2001, Journal of neurochemistry.

Loss of the Effector Function in a Transducin-α Mutant Associated with Nougaret Night Blindness*

N. Artemyev, K. Muradov, Khakim G. Muradov, 2000, The Journal of Biological Chemistry.

Mutational analysis of functional interfaces of transducin.

N. Artemyev, M. Natochin, 2000, Methods in enzymology.

Roles of the Transducin α-Subunit α4-Helix/α4-β6 Loop in the Receptor and Effector Interactions*

N. Artemyev, M. Natochin, A. Granovsky, 1999, The Journal of Biological Chemistry.

Identification of Effector Residues on Photoreceptor G Protein, Transducin*

N. Artemyev, M. Natochin, A. Granovsky, 1998, The Journal of Biological Chemistry.

Sites of interaction between rod G-protein alpha-subunit and cGMP-phosphodiesterase gamma-subunit. Implications for the phosphodiesterase activation mechanism.

H. Hamm, N. Skiba, N. Artemyev, 1992, The Journal of biological chemistry.

The solution structure of the transducin‐α–uncoordinated 119 protein complex suggests occlusion of the Gβ1γ1‐binding sites

L. Gakhar, N. Artemyev, R. Yadav, 2015, The FEBS journal.

G-Protein–Effector Coupling in the Vertebrate Phototransduction Cascade

N. Artemyev, 2014 .

Analysis of PDE6 function using chimeric PDE5/6 catalytic domains

N. Artemyev, Kimberly K. Boyd, H. Muradov, 2006, Vision Research.

Partial Reconstitution of Photoreceptor cGMP Phosphodiesterase Characteristics in cGMP Phosphodiesterase-5*

N. Artemyev, A. Granovsky, 2001, The Journal of Biological Chemistry.

Identification of the γ Subunit-interacting Residues on Photoreceptor cGMP Phosphodiesterase, PDE6α′*

N. Artemyev, A. Granovsky, 2000, The Journal of Biological Chemistry.

Probing Domain Functions of Chimeric PDE6α′/PDE5 cGMP-Phosphodiesterase*

N. Artemyev, J. Corbin, S. Francis, 1998, The Journal of Biological Chemistry.

Two-site high-affinity interaction between inhibitory and catalytic subunits of rod cyclic GMP phosphodiesterase.

H. Hamm, N. Artemyev, 1992, The Biochemical journal.

A nonhuman primate model of inherited retinal disease

C. Murphy, Rui Chen, R. Harris, 2019, The Journal of clinical investigation.

α2δ-4 Is Required for the Molecular and Structural Organization of Rod and Cone Photoreceptor Synapses

Joseph G. Laird, R. Wong, S. Baker, 2018, The Journal of Neuroscience.

Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis

J. Beavo, N. Artemyev, L. Jaffe, 2016, Biology of reproduction.

Atypical retinal degeneration 3 in mice is caused by defective PDE6B pre-mRNA splicing

N. Artemyev, Kimberly K. Boyd, H. Muradov, 2012, Vision Research.

Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1.

D. Srivastava, N. Artemyev, R. Yadav, 2023, Structure.

Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor

D. Srivastava, L. Gakhar, N. Artemyev, 2019, Nature Communications.

The GAFa Domains of Rod cGMP-phosphodiesterase 6 Determine the Selectivity of the Enzyme Dimerization*

J. Beavo, N. Artemyev, S. Martinez, 2003, The Journal of Biological Chemistry.

Dysregulation of Cav1.4 channels disrupts the maturation of photoreceptor synaptic ribbons in congenital stationary night blindness type 2

S. Baker, N. Artemyev, A. Majumder, 2013, Channels.

Chaperones and retinal disorders.

M. Sokolov, N. Artemyev, R. Yadav, 2019, Advances in protein chemistry and structural biology.

Modulation of transducin GTPase activity by chimeric RGS16 and RGS9 regulators of G protein signaling and the effector molecule.

N. Artemyev, R. McEntaffer, M. Natochin, 1999, Biochemistry.

Interaction of the tetratricopeptide repeat domain of aryl hydrocarbon receptor–interacting protein–like 1 with the regulatory Pγ subunit of phosphodiesterase 6

Liping Yu, N. Artemyev, R. Yadav, 2019, The Journal of Biological Chemistry.

Structural basis of phosphodiesterase 6 inhibition by the C‐terminal region of the γ‐subunit

L. Gakhar, N. Artemyev, S. Ramaswamy, 2009, The EMBO journal.

Phosphodiesterase 6B, cGMP-specific rod beta

N. Artemyev, 2008 .

Phosphodiesterase 6A, cGMP-specific rod alpha

N. Artemyev, 2008 .

Intrinsically disordered γ-subunit of cGMP phosphodiesterase encodes functionally relevant transient secondary and tertiary structure

John L Markley, J. Markley, Jikui Song, 2008, Proceedings of the National Academy of Sciences.

Phototransduction in a Transgenic Mouse Model of Nougaret Night Blindness

J. Hurley, Desheng Chen, W. W. Rubin, 2006, The Journal of Neuroscience.

AGS3 Inhibits GDP Dissociation from Gα Subunits of the Gi Family and Rhodopsin-dependent Activation of Transducin*

Y. Peterson, N. Artemyev, M. Bernard, 2000, The Journal of Biological Chemistry.

AIPL1: A specialized chaperone for the phototransduction effector.

N. Artemyev, R. Yadav, 2017, Cellular signalling.

NMR resonance assignments of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) in complex with a farnesyl ligand

Liping Yu, N. Artemyev, R. Yadav, 2017, Biomolecular NMR Assignments.

Interaction of transducin-α with LGN, a G-protein modulator expressed in photoreceptor cells

N. Artemyev, M. Natochin, V. S. Kerov, 2005, Molecular and Cellular Neuroscience.

Unique structural features of the AIPL1–FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness

Liping Yu, L. Gakhar, N. Artemyev, 2017, Proceedings of the National Academy of Sciences.

Aryl Hydrocarbon Receptor-interacting Protein-like 1 Is an Obligate Chaperone of Phosphodiesterase 6 and Is Assisted by the γ-Subunit of Its Client*

N. Artemyev, R. Yadav, K. Gopalakrishna, 2016, The Journal of Biological Chemistry.

Light-Dependent Compartmentalization of Transducin in Rod Photoreceptors

N. Artemyev, 2008, Molecular Neurobiology.

Ric-8A, a GEF, and a Chaperone for G Protein α-Subunits: Evidence for the Two-Faced Interface.

D. Srivastava, N. Artemyev, 2020, BioEssays : news and reviews in molecular, cellular and developmental biology.

A Novel Role for UNC119 as an Enhancer of Synaptic Transmission

G. Fain, N. Artemyev, A. Majumder, 2023, International journal of molecular sciences.

Probing G-protein function

H. Hamm, N. Artemyev, 1994, Nature Structural Biology.

Diffusion and light-dependent compartmentalization of transducin

N. Artemyev, Vasily Kerov, 2011, Molecular and Cellular Neuroscience.

Unique transducins expressed in long and short photoreceptors of lamprey Petromyzon marinus

N. Artemyev, Kimberly K. Boyd, H. Muradov, 2008, Vision Research.

Ex Vivo Functional Evaluation of Synaptic Transmission from Rods to Rod Bipolar Cells in Mice.

N. Artemyev, A. Majumder, Johan Pahlberg, 2018, Methods in molecular biology.

Transducin Activation State Controls Its Light-dependent Translocation in Rod Photoreceptors*

Desheng Chen, M. Moussaif, N. Artemyev, 2005, Journal of Biological Chemistry.

Structural determinants of the PDE6 GAF A domain for binding the inhibitory γ-subunit and noncatalytic cGMP

N. Artemyev, Kimberly K. Boyd, H. Muradov, 2004, Vision Research.

Transducin translocation contributes to rod survival and enhances synaptic transmission from rods to rod bipolar cells

N. Artemyev, A. Majumder, V. Ramamurthy, 2013, Proceedings of the National Academy of Sciences.

Subunit Structure of Rod cGMP-Phosphodiesterase*

H. Hamm, N. Artemyev, R. Surendran, 1996, The Journal of Biological Chemistry.

Rhodopsin Determinants for Transducin Activation

M. Moussaif, N. Artemyev, M. Natochin, 2003, Journal of Biological Chemistry.

The GAFa domain of phosphodiesterase‐6 contains a rod outer segment localization signal

N. Artemyev, Zhongmin Zhang, P. Cheguru, 2014, Journal of neurochemistry.

Mechanisms of dominant negative G-protein alpha subunits.

N. Artemyev, Brandy Barren, 2007, Journal of Neuroscience Research.

A dual role for Cav1.4 Ca2+ channels in the molecular and structural organization of the rod photoreceptor synapse

M. Hoon, S. Baker, N. Artemyev, 2020, eLife.

Interaction of transducin-alpha with LGN, a G-protein modulator expressed in photoreceptor cells.

N. Artemyev, M. Natochin, V. S. Kerov, 2005, Molecular and cellular neurosciences.

The Drosophila rhodopsin cytoplasmic tail domain is required for maintenance of rhabdomere structure

N. Artemyev, M. Natochin, J. O'Tousa, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mutation in rod PDE6 linked to congenital stationary night blindness impairs the enzyme inhibition by its gamma-subunit.

N. Artemyev, A. Granovsky, K. Muradov, 2003, Biochemistry.

The carboxyl terminus of the gamma-subunit of rod cGMP phosphodiesterase contains distinct sites of interaction with the enzyme catalytic subunits and the alpha-subunit of transducin.

H. Hamm, N. Skiba, N. Artemyev, 1995, The Journal of biological chemistry.

Hsp40 Couples with the CSPα Chaperone Complex upon Induction of the Heat Shock Response

N. Artemyev, A. Braun, J. Braun, 2009, PloS one.

The trimeric GTP-binding protein (G(q)/G(11)) alpha subunit is required for insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes.

M. Kanzaki, R. Watson, N. Artemyev, 2000, The Journal of biological chemistry.

Characterization of the G alpha(s) regulator cysteine string protein.

N. Artemyev, S. Hameed, M. Natochin, 2005, Journal of Biological Chemistry.

NMR resonance assignments of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) in complex with a farnesyl ligand

Liping Yu, N. Artemyev, R. Yadav, 2017, Biomolecular NMR assignments.

Interaction of human retinal RGS with G-protein alpha-subunits.

N. Artemyev, M. Natochin, V. Lipkin, 1997, FEBS Letters.

Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod Photoreceptors Mimics in Part Features of Light Adaptation

N. Artemyev, A. Majumder, A. Sampath, 2015, The Journal of Neuroscience.

NMR resonance assignments of the TPR domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1)

Liping Yu, N. Artemyev, R. Yadav, 2018, Biomolecular NMR Assignments.

Reconstitution of the phosphodiesterase 6 maturation process important for photoreceptor cell function

D. Srivastava, N. Artemyev, Sneha Singh, 2023, The Journal of biological chemistry.

Coupling between the N- and C-terminal domains influences transducin-alpha intrinsic GDP/GTP exchange.

N. Artemyev, K. Muradov, 2000, Biochemistry.