Krishnapriya Chinnaswamy

发表

Conformational Sampling and Binding Site Assessment of Suppression of Tumorigenicity 2 Ectodomain

Chao-yie Yang, James Delproposto, W. C. Brown, 2016, PloS one.

Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER).

Shaomeng Wang, Chao-yie Yang, James Delproposto, 2019, Journal of medicinal chemistry.

A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation

Liu Liu, Shaomeng Wang, Chao-yie Yang, 2017, Nature Communications.

Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands.

Shaomeng Wang, Chao-yie Yang, J. Stuckey, 2019, Journal of medicinal chemistry.

Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer.

Shaomeng Wang, Chao-yie Yang, James Delproposto, 2019, Journal of medicinal chemistry.

Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression.

Shaomeng Wang, S. Gross, J. Stuckey, 2021, Journal of medicinal chemistry.

Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction.

Liu Liu, Shaomeng Wang, James Delproposto, 2019, Journal of medicinal chemistry.

Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.

Liu Liu, Shaomeng Wang, J. Stuckey, 2018, Angewandte Chemie.

Substrate Specificity of Widely Expressed Subtilisin-like Proprotein Convertases by Arasakumar Subramani

Krishnapriya Chinnaswamy, J. Sucic, Arasakumar Subramani, 2016 .

Changing the Ap Evolutionary Pro

Design, Yang Zhang, Huang, 2019 .

Changing the Ap through Evolutio

Yang Zhang, Huang, Liu Liu, 2019 .

Effects of age and retinal degeneration on the expression of proprotein convertases in the visual cortex

Krishnapriya Chinnaswamy, J. Sucic, A. Sturtevant, 2010, Brain Research.

Structure-Activity relationship of 1-(Furan-2ylmethyl)Pyrrolidine-Based Stimulation-2 (ST2) inhibitors for treating graft versus host disease.

Chao-yie Yang, J. Stuckey, Krishnapriya Chinnaswamy, 2022, Bioorganic & medicinal chemistry.

Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors.

Liu Liu, Shaomeng Wang, J. Stuckey, 2015, Journal of medicinal chemistry.

Computational Cosolvent Mapping Analysis Leads to Identify Salicylic Acid Analogs as Weak Inhibitors of ST2 and IL33 Binding.

J. Stuckey, Krishnapriya Chinnaswamy, Xinrui Yuan, 2022, The journal of physical chemistry. B.

Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor

N. Neamati, J. Sebolt-Leopold, M. Ljungman, 2016, Nature Communications.

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.

Liu Liu, Shaomeng Wang, J. Stuckey, 2019, Cancer cell.

From proteomics to discovery of first-in-class ST2 inhibitors active in vivo.

Greg L. Hura, J. Stuckey, Krishnapriya Chinnaswamy, 2018, JCI insight.

Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression.

Shaomeng Wang, J. Stuckey, D. McEachern, 2021, Journal of medicinal chemistry.

CSAR Data Set Release 2012: Ligands, Affinities, Complexes, and Docking Decoys

Richard D. Smith, Heather A. Carlson, Emilio Xavier Esposito, 2013, J. Chem. Inf. Model..

Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors.

James Delproposto, J. Stuckey, Krishnapriya Chinnaswamy, 2016, ACS medicinal chemistry letters.

Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity

Liu Liu, Shaomeng Wang, Yi Sun, 2021, Nature Communications.

A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation

Liu Liu, Shaomeng Wang, Yi Sun, 2017, Nature Communications.

Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-Apoptotic Mcl-1 and Bfl-1 Proteins.

Z. Nikolovska-Coleska, J. Stuckey, Krishnapriya Chinnaswamy, 2020, Journal of medicinal chemistry.

CSAR Benchmark Exercise 2013: Evaluation of Results from a Combined Computational Protein Design, Docking, and Scoring/Ranking Challenge

Richard D. Smith, Heather A. Carlson, David Baker, 2016, J. Chem. Inf. Model..

Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong In Vivo Antitumor Activity.

Shaomeng Wang, J. Stuckey, D. McEachern, 2020, Journal of medicinal chemistry.

Structure-Based Discovery of SD-36 as a Potent, Selective and Efficacious PROTAC Degrader of STAT3 Protein.

Liu Liu, Shaomeng Wang, J. Stuckey, 2019, Journal of medicinal chemistry.

EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development.

Shaomeng Wang, J. Stuckey, D. McEachern, 2020, Journal of medicinal chemistry.

High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction.

Liu Liu, Shaomeng Wang, Yi Sun, 2018, Journal of Medicinal Chemistry.

Changing the Apoptosis Pathway through Evolutionary Protein Design.

Pralay Mitra, Yang Zhang, Christoph H. Borchers, 2019, Journal of molecular biology.

SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.

Shaomeng Wang, J. Stuckey, D. McEachern, 2021, ACS medicinal chemistry letters.

Profiling the Binding Activities of Peptides and Inhibitors to the U2 Auxiliary Factor Homology Motif (UHM) Domains.

J. Stuckey, Krishnapriya Chinnaswamy, Xinrui Yuan, 2023, ACS medicinal chemistry letters.

Prophylactic Mitigation of Acute Graft versus Host Disease by Novel 2-(Pyrrolidin-1-ylmethyl)pyrrole-Based Stimulation-2 (ST2) Inhibitors.

J. Stuckey, Krishnapriya Chinnaswamy, Hebao Yuan, 2023, ACS pharmacology & translational science.

Structure-Activity relationship of 1-(Furan-2ylmethyl)Pyrrolidine-Based Stimulation-2 (ST2) inhibitors for treating graft versus host disease.

J. Stuckey, Krishnapriya Chinnaswamy, Hebao Yuan, 2022, Bioorganic & medicinal chemistry.

Effects of age and retinal degeneration on the expression of proprotein convertases in the visual cortex

Krishnapriya Chinnaswamy, J. Sucic, A. Sturtevant, 2010, Brain Research.