M. Treuheit

发表

Small-angle neutron scattering study of a monoclonal antibody using free-energy constraints.

Nicholas J. Clark, Randal R Ketchem, A. Mcauley, 2013, The journal of physical chemistry. B.

Formation of pyroglutamic acid from N-terminal glutamic acid in immunoglobulin gamma antibodies.

Rahul S Rajan, Michael J Treuheit, Douglas S Rehder, 2006, Analytical chemistry.

An improved trypsin digestion method minimizes digestion-induced modifications on proteins.

Liang-Yu Shih, Da Ren, Michael J Treuheit, 2009, Analytical biochemistry.

Degradation products analysis of an Fc fusion protein using LC/MS methods.

D. Brems, P. Bondarenko, D. Ren, 2009, International journal of biological macromolecules.

Automated tryptic digestion procedure for HPLC/MS/MS peptide mapping of immunoglobulin gamma antibodies in pharmaceutics.

Michael J Treuheit, Douglas S Rehder, D. Chelius, 2008, Journal of pharmaceutical and biomedical analysis.

PEGylation Prevents the N-Terminal Degradation of Megakaryocyte Growth and Development Factor

D. Brems, M. Treuheit, Janice M. Davis, 1998, Pharmaceutical Research.

Resolving Liquid-Liquid Phase Separation for a Peptide Fused Monoclonal Antibody by Formulation Optimization.

Deniz B. Temel, M. Treuheit, V. Razinkov, 2020, Journal of pharmaceutical sciences.

O-fucosylation of an antibody light chain: characterization of a modification occurring on an IgG1 molecule.

B. Yan, John F. Valliere-Douglass, Alison Wallace, 2008, Glycobiology.

Top-down N-terminal sequencing of Immunoglobulin subunits with electrospray ionization time of flight mass spectrometry.

P. Bondarenko, D. Ren, D. Hambly, 2009, Analytical biochemistry.

Characterization and Stability of N-terminally PEGylated rhG-CSF

D. Brems, M. Treuheit, O. Kinstler, 1996, Pharmaceutical Research.

Site-specific conjugation of diethylenetriaminepentaacetic acid to recombinant human granulocyte-colony-stimulating factor: preservation of protein structure and function.

V. Katta, M. Treuheit, D. C. Litzinger, 1995, Biochemistry.

Effects of Monovalent Salt on Protein-Protein Interactions of Dilute and Concentrated Monoclonal Antibody Formulations

Nicholas J. Clark, A. Mcauley, S. Krueger, 2022, Antibodies.

A method for preparing chelate-cytokine conjugates with retention of protein structure, biological activity, and pharmacokinetic properties.

M. Treuheit, M. Woodward, D. C. Litzinger, 1995, Journal of immunological methods.

Control of Antibody Impurities Induced by Riboflavin in Culture Media During Production.

John F. Valliere-Douglass, Alison Wallace, A. Balland, 2019, Journal of pharmaceutical sciences.

Protein nebulization. II. Stabilization of G-CSF to air-jet nebulization and the role of protectants

T. Arakawa, M. Treuheit, R. Niven, 1996 .

Purification of the glycosylated beta subunit of (Na,K)-ATPase by lectin affinity chromatography

M. Treuheit, T. Kirley, E. Wallick, 1992 .

Sustained in vivo activity of recombinant human granulocyte colony stimulating factor (rHG-CSF) incorporated into hyaluronan

M. Treuheit, D. Collins, James T. Meyer, 1995 .

Isolation of clobazam-orosomucoid complexes from patients' sera.

H. Halsall, M. Treuheit, 1992, Biomedical chromatography : BMC.

Photochemical degradation of citrate buffers leads to covalent acetonation of recombinant protein therapeutics

P. Schnier, John F. Valliere-Douglass, A. Balland, 2010, Protein science : a publication of the Protein Society.

Optimization and Applications of CDAP Labeling for the Assignment of Cysteines

G. Kleemann, M. Treuheit, G. Pipes, 2005, Pharmaceutical Research.

Characterization of site-specific glycation during process development of a human therapeutic monoclonal antibody.

Bruce A Kerwin, Michael J Treuheit, D. Hambly, 2011, Journal of pharmaceutical sciences.

The LC/MS analysis of glycation of IgG molecules in sucrose containing formulations.

Margaret Ricci, Douglas S Rehder, A. Mcauley, 2007, Journal of pharmaceutical sciences.

Screening and sequencing of glycated proteins by neutral loss scan LC/MS/MS method.

P. Bondarenko, D. Ren, H. Gadgil, 2007, Analytical chemistry.

Restricted variation in the glycosylation of human α1-acid glycoprotein

H. Halsall, M. Treuheit, 1993 .

Disease-coupled specificity in the glycan structures of orosomucoid.

H. Halsall, M. Treuheit, 1992, Clinica chimica acta; international journal of clinical chemistry.

Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein.

H. Halsall, M. Treuheit, C. Costello, 1992, The Biochemical journal.

HPLC of individual site glycoforms in serum orosomucoid

H. Halsall, M. Treuheit, 1991 .

LC/MS analysis of complex multiglycosylated human alpha(1)-acid glycoprotein as a model for developing identification and quantitation methods for intact glycopeptide analysis.

H. Halsall, H. Gadgil, M. Treuheit, 2010, Analytical biochemistry.

The glycan patterns at the individual glycosylation sites in orosomucoid from allergic reaction patients

H. Halsall, M. Treuheit, 1993 .

Mg(2+)-ATPase from rabbit skeletal muscle transverse tubules is 67-kilodalton glycoprotein.

M. Treuheit, T. Kirley, P. Vaghy, 1992, The Journal of biological chemistry.

Modulation of protein aggregation by polyethylene glycol conjugation: GCSF as a case study

D. Brems, Rahul S. Rajan, M. Treuheit, 2006, Protein science : a publication of the Protein Society.

Mono-N-terminal poly(ethylene glycol)-protein conjugates.

M. Treuheit, C. Gegg, G. Molineux, 2002, Advanced drug delivery reviews.

Improving mass accuracy of high performance liquid chromatography/electrospray ionization time-of-flight mass spectrometry of intact antibodies

T. Dillon, P. Bondarenko, H. Gadgil, 2006, Journal of the American Society for Mass Spectrometry.

Glutamine-linked and Non-consensus Asparagine-linked Oligosaccharides Present in Human Recombinant Antibodies Define Novel Protein Glycosylation Motifs

Alain Balland, Michael J Treuheit, Randal R Ketchem, 2010, The Journal of Biological Chemistry.

Asparagine-linked Oligosaccharides Present on a Non-consensus Amino Acid Sequence in the CH1 Domain of Human Antibodies

Alain Balland, B. Yan, John F. Valliere-Douglass, 2009, The Journal of Biological Chemistry.

Antibodies 1 Domain of HumanHSequence in the C Present on a Non-consensus Amino Acid Asparagine-linked Oligosaccharides Modification , and Degradation : Protein Synthesis , Post-Translational

B. Yan, A. Balland, M. Treuheit, 2009 .

The existence of a ligand bound to the serum orosomucoid of cigarette smokers

H. B. Halsall, H. Halsall, M. Treuheit, 1991 .

Comparison of LC and LC/MS methods for quantifying N-glycosylation in recombinant IgGs

P. Bondarenko, H. Gadgil, E. Topp, 2008, Journal of the American Society for Mass Spectrometry.

Reversed-phase liquid chromatography-mass spectrometry of site-specific chemical modifications in intact immunoglobulin molecules and their fragments.

Gang Xiao, P. Bondarenko, D. Ren, 2008, Journal of chromatography. A.

Inverse Relationship of Protein Concentration and Aggregation

D. Brems, M. Treuheit, A. Kosky, 2002, Pharmaceutical Research.

Structural Changes and Aggregation Mechanisms of Two Different Dimers of an IgG2 Monoclonal Antibody.

D. Volkin, M. Treuheit, Feng He, 2018, Biochemistry.

Aggregation of granulocyte‐colony stimulating factor in vitro involves a conformationally altered monomeric state

J. King, D. Brems, M. Treuheit, 2005, Protein science : a publication of the Protein Society.

Accelerated Formulation Development of Monoclonal Antibodies (mAbs) and mAb-Based Modalities

Vladimir I Razinkov, Michael J Treuheit, Gerald W Becker, 2015, Journal of biomolecular screening.

High-Throughput Screening and Stability Optimization of Anti-Streptavidin IgG1 and IgG2 Formulations

Vladimir I. Razinkov, M. Treuheit, V. Razinkov, 2014, Journal of biomolecular screening.

Identification of cysteinylation of a free cysteine in the Fab region of a recombinant monoclonal IgG1 antibody using Lys-C limited proteolysis coupled with LC/MS analysis.

Gerd R Kleemann, Jeffrey Abel, Michael J Treuheit, 2006, Analytical biochemistry.

Structures of the complex glycans found on the beta-subunit of (Na,K)-ATPase.

M. Treuheit, C. Costello, T. Kirley, 1993, The Journal of biological chemistry.

Effects of sucrose and benzyl alcohol on GCSF conformational dynamics revealed by hydrogen deuterium exchange mass spectrometry.

Jun Zhang, Feng He, Michael J Treuheit, 2015, Journal of pharmaceutical sciences.

Middle-down fragmentation for the identification and quantitation of site-specific methionine oxidation in an IgG1 molecule.

P. Bondarenko, H. Gadgil, B. Kerwin, 2010, Journal of pharmaceutical sciences.

Reversed-phase liquid chromatography of immunoglobulin G molecules and their fragments with the diphenyl column.

D. Brems, P. Bondarenko, D. Ren, 2007, Journal of chromatography. A.

Sodium Chloride Enhances the Storage and Conformational Stability of BDNF and PEG-BDNF

L. Narhi, M. Treuheit, A. Kosky, 2001, Pharmaceutical Research.

The effects of alpha‐helix on the stability of Asn residues: Deamidation rates in peptides of varying helicity

D. Brems, M. Treuheit, A. Kosky, 2008, Protein science : a publication of the Protein Society.

Instability of Cysteine Labeling With 4-(aminosulfonyl)-7-fluoro-2, 1, 3-benzoxadiazole (ABD-F)

M. Treuheit, T. Kirley, 1994 .

Optimized UV detection of high-concentration antibody formulations using high-throughput SE-HPLC.

Gerd R Kleemann, Michael J Treuheit, R Matthew Fesinmeyer, 2015, Journal of pharmaceutical sciences.

Methods of high throughput biophysical characterization in biopharmaceutical development.

M. Treuheit, V. Razinkov, G. Becker, 2013, Current drug discovery technologies.

High-Throughput Screening and Analysis of Charge Variants of Monoclonal Antibodies in Multiple Formulations

M. Treuheit, V. Razinkov, G. Becker, 2017, SLAS discovery : advancing life sciences R & D.

Characterization of site-specific glycation during process development of a human therapeutic monoclonal antibody.

D. Hambly, H. Gadgil, B. Kerwin, 2011, Journal of pharmaceutical sciences.