A. Tron

发表

Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface.

J. Decaprio, B. Schulman, M. Hammel, 2012, Molecular cell.

The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7.

S. Signoretti, J. Decaprio, Y. Fujiwara, 2012, Molecular cell.

Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression.

Shaomeng Wang, S. Gross, J. Stuckey, 2021, Journal of medicinal chemistry.

Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase.

J. Decaprio, Wenyi Wei, Xiao Zhen Zhou, 2012, Molecular cell.

Redox Regulation of Plant Homeodomain Transcription Factors*

C. Bertoncini, A. Tron, D. Gonzalez, 2002, The Journal of Biological Chemistry.

Combinatorial interactions of two amino acids with a single base pair define target site specificity in plant dimeric homeodomain proteins.

C. Bertoncini, A. Tron, D. Gonzalez, 2001, Nucleic acids research.

Positively charged residues at the N-terminal arm of the homeodomain are required for efficient DNA binding by homeodomain-leucine zipper proteins.

C. Bertoncini, A. Tron, D. Gonzalez, 2001, Journal of molecular biology.

Regulation of the Promyelocytic Leukemia Protein and Its Role in Premature Senescence

Wenyi Wei, A. Tron, A. Lau, 2014 .

Structure of homeodomain-leucine zipper/DNA complexes studied using hydroxyl radical cleavage of DNA and methylation interference.

A. Tron, D. Gonzalez, R. Comelli, 2005, Biochemistry.

Engineering the loop region of a homeodomain-leucine zipper protein promotes efficient binding to a monomeric DNA binding site.

A. Tron, D. Gonzalez, E. Welchen, 2004, Biochemistry.

Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma

Christine C. Hudson, A. Tron, Brandon Nicolay, 2022, Journal for ImmunoTherapy of Cancer.

Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress

A. Tron, D. Perrotti, R. Trotta, 2016, Oncotarget.

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

J. A. Hendricks, David M. Wilson, S. Kazmirski, 2018, Nature Communications.

Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells

L. Kats, R. Johnstone, A. Tron, 2022, bioRxiv.

PARC and CUL7 form atypical cullin RING ligase complexes.

M. Washburn, J. Decaprio, L. Florens, 2007, Cancer research.

SCFβ-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration

Zhiwei Wang, Wenyi Wei, A. Tron, 2013, Oncotarget.

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

S. Gygi, A. Toker, J. Decaprio, 2010, Molecular cell.

Recent advances in the development of Mcl-1 inhibitors for cancer therapy.

A. Tron, A. Hird, 2019, Pharmacology & therapeutics.

Concurrent Inhibition of Pim and FLT3 Kinases Enhances Apoptosis of FLT3-ITD Acute Myeloid Leukemia Cells through Increased Mcl-1 Proteasomal Degradation

A. Tron, D. Perrotti, R. Trotta, 2017, Clinical Cancer Research.

Multiscale Model Identifies Improved Schedule for Treatment of Acute Myeloid Leukemia In Vitro With the Mcl‐1 Inhibitor AZD5991

B. Aldridge, L. Drew, A. Tron, 2020, CPT: pharmacometrics & systems pharmacology.

Next-generation sequencing identifies a novel ELAVL1–TYK2 fusion gene in MOLM-16, an AML cell line highly sensitive to the PIM kinase inhibitor AZD1208

A. Khwaja, A. Tron, D. Linch, 2016, Leukemia & lymphoma.

Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies

Charles H. Yoon, A. Letai, K. Flaherty, 2019, Nature Communications.

Preclinical Activity of Novel MCL1 Inhibitor AZD5991 in Multiple Myeloma

J. Keats, S. Lonial, A. Tron, 2018, Blood.

Concurrent Inhibition of Pim-1 and FLT3 Kinases in FLT3-ITD Acute Myeloid Leukemia Post-Translationally Downregulates the Anti-Apoptotic Protein Mcl-1 through Downregulation of the Mcl-1 Deubiquitinase USP9X

A. Tron, D. Perrotti, R. Trotta, 2016 .

SCFβ-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration

Zhiwei Wang, Wenyi Wei, A. Tron, 2013, Oncotarget.

Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase.

J. Decaprio, Wenyi Wei, Xiao Zhen Zhou, 2012, Molecular cell.

Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity

N. Bardeesy, K. Yates, A. Tron, 2024, Science.