P. Cherepanov

发表

Solution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA.

F. Bushman, S. Krueger, J. E. Curtis, 2012, Structure.

The Lentiviral Integrase Binding Protein LEDGF/p75 and HIV-1 Replication

A. Engelman, P. Cherepanov, Alan Engelman, 2008, PLoS pathogens.

Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein.

E. De Clercq, P. Cherepanov, Z. Debyser, 1999, Virology.

HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human Cells*

Zeger Debyser, Yves Engelborghs, Bart Devreese, 2003, The Journal of Biological Chemistry.

A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

A. Engelman, P. Cherepanov, G. Maertens, 2006, Nucleic acids research.

Structural basis for retroviral integration into nucleosomes

Rishi Matadeen, Ludovic Renault, Alessandro Costa, 2015, Nature.

Retroviral intasome assembly and inhibition of DNA strand transfer

A. Engelman, E. Valkov, P. Cherepanov, 2010, Nature.

Key determinants of target DNA recognition by retroviral intasomes

A. Engelman, Erik Serrao, P. Cherepanov, 2015, Retrovirology.

The structural biology of HIV-1: mechanistic and therapeutic insights

A. Engelman, P. Cherepanov, 2012, Nature Reviews Microbiology.

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

A. Engelman, T. Ellenberger, P. Cherepanov, 2005, Proceedings of the National Academy of Sciences of the United States of America.

A bipartite structural organization defines the SERINC family of HIV-1 restriction factors

C. Robinson, Y. Takeuchi, V. E. Pye, 2019, Nature structural & molecular biology.

Expression of HIV‐1 integrase in CEM cells inhibits HIV‐1 replication

E. De Clercq, P. Cherepanov, J. van Griensven, 2004, The journal of gene medicine.

In Search of Authentic Inhibitors of HIV-1 Integration

E. De Clercq, P. Cherepanov, Z. Debyser, 2002, Antiviral chemistry & chemotherapy.

LcrV is a channel size‐determining component of the Yop effector translocon of Yersinia

R. Benz, P. Cherepanov, A. Holmström, 2001, Molecular microbiology.

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding

Goedele N. Maertens, A. Engelman, Erik Serrao, 2014, Nucleic acids research.

Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir ( S / GSK 1349572 )

Y. Pommier, S. Hughes, Steven J Smith, 2011 .

Activities, crystal structures, and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase.

Y. Pommier, S. Hughes, Steven J Smith, 2013, ACS chemical biology.

pH6 antigen of Yersinia pestis interacts with plasma lipoproteins and cell membranes Published, JLR Papers in Press, November 16, 2002. DOI 10.1194/jlr.M200182-JLR200

P. Cherepanov, G. Olivecrona, S. Lundberg, 2003, Journal of Lipid Research.

Multivalent interactions essential for lentiviral integrase function

A. Engelman, I. Taylor, N. Cook, 2022, Nature communications.

A supramolecular assembly mediates lentiviral DNA integration

A. Engelman, Erik Serrao, I. Taylor, 2017, Science.

Cryo-EM reveals a novel octameric integrase structure for β-retroviral intasome function

A. Engelman, N. Cook, D. Lyumkis, 2016, Nature.

Lys-34, Dispensable for Integrase Catalysis, Is Required for Preintegration Complex Function and Human Immunodeficiency Virus Type 1 Replication

A. Engelman, P. Cherepanov, N. Vandegraaff, 2005, Journal of Virology.

Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness.

A. Engelman, P. Cherepanov, Shaila Rahman, 2007, Virology.

Activity of recombinant HIV-1 integrase on mini-HIV DNA.

E. De Clercq, J. Griffith, P. Cherepanov, 1999, Nucleic Acids Research.

Mode of interaction of G-quartets with the integrase of human immunodeficiency virus type 1.

E. De Clercq, P. Cherepanov, G. Reekmans, 1997, Molecular pharmacology.

Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ

V. E. Pye, P. Cherepanov, G. Maertens, 2020, Nature Communications.

Retroviral intasomes arising.

A. Engelman, P. Cherepanov, 2017, Current opinion in structural biology.

Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer

D. Rueda, V. E. Pye, Alessandro Costa, 2019, Nature Communications.

Severe Acute Respiratory Syndrome Coronavirus 2 Serosurveillance in a Patient Population Reveals Differences in Virus Exposure and Antibody-Mediated Immunity According to Host Demography and Healthcare Setting

P. Cherepanov, C. Roustan, P. Murcia, 2020, The Journal of infectious diseases.

Detection and Quantification of Antibody to SARS-CoV-2 Receptor Binding Domain Provides Enhanced Sensitivity, Specificity and Utility

R. Tedder, G. Cooke, P. Cherepanov, 2021, SSRN Electronic Journal.

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

A. Engelman, S. Hughes, Steven J Smith, 2012, Nucleic acids research.

A neutralizing epitope on the SD1 domain of SARS-CoV-2 spike targeted following infection and vaccination

M. Malim, V. E. Pye, P. Cherepanov, 2022, Cell Reports.

Characterization of a dam Mutant ofSerratia marcescens and Nucleotide Sequence of thedam Region

W. Wackernagel, P. Cherepanov, J. de Vries, 1999, Journal of bacteriology.

Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir).

E. De Clercq, C. Pannecouque, B. Clotet, 1998, Molecular pharmacology.

B-to-A transition in target DNA during retroviral integration

A. Engelman, D. Lyumkis, P. Cherepanov, 2022, Nucleic acids research.

High‐level expression of active HIV‐1 integrase from a synthetic gene in human cells

P. Proost, P. Cherepanov, E. Clercq, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Structural aspects of Lentiviral Integrase-LEDGF interaction

A. Engelman, P. Cherepanov, S. Hare, 2011 .

Class II Integrase Mutants with Changes in Putative Nuclear Localization Signals Are Primarily Blocked at a Postnuclear Entry Step of Human Immunodeficiency Virus Type 1 Replication

A. Engelman, P. Silver, P. Cherepanov, 2004, Journal of Virology.

Bmc Microbiology the Yersinia Yope and Yoph Type Iii Effector Proteins Enhance Bacterial Proliferation following Contact with Eukaryotic Cells

P. Cherepanov, K. Schesser, A. Forsberg, 2022 .

Crystal structure of human CDC7 kinase in complex with its activator DBF4

S. Matthews, A. Snijders, P. Cherepanov, 2012, Nature Structural &Molecular Biology.

Retroviral DNA Integration

A. Engelman, P. Cherepanov, P. Lesbats, 2016, Chemical reviews.

Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: Antibody dynamics and linkage to severity of COVID-19 in hospital inpatients

W. Paxton, J. Baillie, R. Tedder, 2022, Journal of Infection.

Structural Basis for Functional Tetramerization of Lentiviral Integrase

A. Engelman, Jimin Wang, P. Cherepanov, 2009, PLoS pathogens.

Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)

Yves Pommier, Stephen H. Hughes, Y. Pommier, 2011, Molecular Pharmacology.

Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance

Maxwell D. Cummings, M. Cummings, R. Clayton, 2010, Proceedings of the National Academy of Sciences.

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration.

A. Engelman, P. Kellam, P. Cherepanov, 2007, Genes & development.

Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration

A. Engelman, Erik Serrao, P. Cherepanov, 2016, PLoS pathogens.

Identification and Characterization of a Functional Nuclear Localization Signal in the HIV-1 Integrase Interactor LEDGF/p75*

A. Engelman, P. Cherepanov, Z. Debyser, 2004, Journal of Biological Chemistry.

Role of Yersinia Murine Toxin in Survival of Yersinia pestis in the Midgut of the Flea Vector

J. Dixon, T. Schwan, B. J. Hinnebusch, 2002, Science.

Murine toxin of Yersinia pestis shows phospholipase D activity but is not required for virulence in mice.

T. Schwan, P. Cherepanov, J. Hinnebusch, 2000, International journal of medical microbiology : IJMM.

Retroviral Integrase Structure and DNA Recombination Mechanism

A. Engelman, P. Cherepanov, 2014, Microbiology spectrum.

The SET Complex Acts as a Barrier to Autointegration of HIV-1

J. Lieberman, Nan Yan, A. Engelman, 2009, PLoS pathogens.

Key determinants of target DNA recognition by retroviral intasomes

A. Engelman, Erik Serrao, P. Cherepanov, 2015, Retrovirology.

Structure and function of retroviral integrase

A. Engelman, P. Cherepanov, G. Maertens, 2021, Nature Reviews Microbiology.

LEDGF/p75 Is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells*

E. De Clercq, P. Cherepanov, Z. Debyser, 2003, Journal of Biological Chemistry.

Structure and function of retroviral integrase

A. Engelman, P. Cherepanov, G. Maertens, 2021, Nature Reviews Microbiology.

Bromo- and Extraterminal Domain Chromatin Regulators Serve as Cofactors for Murine Leukemia Virus Integration

A. Schambach, T. Schulz, P. Cherepanov, 2013, Journal of Virology.

3′-Processing and strand transfer catalysed by retroviral integrase in crystallo

P. Cherepanov, G. Maertens, S. Hare, 2012, The EMBO journal.

The mechanism of retroviral integration through X-ray structures of its key intermediates

Goedele N. Maertens, P. Cherepanov, G. Maertens, 2010, Nature.

Functional and structural characterization of the integrase from the prototype foamy virus

P. Roversi, E. Valkov, P. Cherepanov, 2008, Nucleic acids research.

LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro

P. Cherepanov, 2006, Nucleic acids research.

The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function

A. Engelman, I. Taylor, N. Cook, 2023, mBio.

Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses.

A. Engelman, P. Cherepanov, S. Hare, 2020 .

Efficient transduction of LEDGF/p75 mutant cells by complementary gain-of-function HIV-1 integrase mutant viruses

A. Engelman, P. Cherepanov, F. Di Nunzio, 2014, Molecular therapy. Methods & clinical development.

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

A. Engelman, E. Valkov, P. Cherepanov, 2009, PLoS pathogens.

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

A. Engelman, G. Wagner, P. Cherepanov, 2005, Nature Structural &Molecular Biology.

Identification of an Evolutionarily Conserved Domain in Human Lens Epithelium-derived Growth Factor/Transcriptional Co-activator p75 (LEDGF/p75) That Binds HIV-1 Integrase*

Pamela A. Silver, A. Engelman, P. Silver, 2004, Journal of Biological Chemistry.

HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants

S. Hughes, D. Lyumkis, V. E. Pye, 2021, ACS infectious diseases.

Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors

Stephen H Hughes, Yves Pommier, Xue Zhi Zhao, 2017, Journal of medicinal chemistry.

HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases

Y. Pommier, S. Hughes, V. E. Pye, 2016, ACS chemical biology.

Structural biology of retroviral DNA integration.

A. Engelman, P. Cherepanov, Lavanya Krishnan, 2011, Virology.

Structure-based modeling of the functional HIV-1 intasome and its inhibition

A. Engelman, P. Cherepanov, S. Hare, 2010, Proceedings of the National Academy of Sciences.

The KT Jeang Retrovirology prize 2021: Peter Cherepanov

P. Cherepanov, K. Jeang, 2021, Retrovirology.

Broad human and animal coronavirus neutralisation by SARS-CoV-2 S2-targeted vaccination

C. Swanton, S. Gamblin, J. McCauley, 2021, bioRxiv.

HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome

A. Fassati, P. Cherepanov, Lada Leyens, 2009, Retrovirology.

Plasmodium infection is associated with cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein

M. C. Muenker, Boris Katz, O. Faye, 2022, Scientific reports.

Structural basis for nuclear import of splicing factors by human Transportin 3

A. Engelman, N. Cook, A. Fassati, 2014, Proceedings of the National Academy of Sciences.

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6

A. Engelman, N. Cook, V. E. Pye, 2019, Nucleic acids research.

Structural characterisation of the Chaetomium thermophilum Chl1 helicase

I. Taylor, M. Singleton, P. Cherepanov, 2021, PloS one.

Structural basis for spumavirus GAG tethering to chromatin

A. Engelman, Erik Serrao, V. E. Pye, 2017, Proceedings of the National Academy of Sciences.

Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase

V. E. Pye, P. Cherepanov, N. O'Reilly, 2020, Structure.

Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis

L. Collinson, Kuan-Chung Su, V. E. Pye, 2012, Nature.

The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights

P. Cherepanov, S. Hare, 2009, Viruses.

Close‐up: HIV/SIV intasome structures shed new light on integrase inhibitor binding and viral escape mechanisms

A. Engelman, P. Cherepanov, 2020, The FEBS journal.

Structural basis of second-generation HIV integrase inhibitor action and viral resistance

A. Engelman, N. Cook, E. Rosta, 2020, Science.

Transcriptional Co-activator LEDGF Interacts with Cdc7-Activator of S-phase Kinase (ASK) and Stimulates Its Enzymatic Activity*

A. Engelman, P. Cherepanov, Mohd Jamal Dar, 2009, The Journal of Biological Chemistry.

DNA-Dependent Protein Kinase Is Not Required for Efficient Lentivirus Integration

B. de Strooper, E. De Clercq, B. Nuttin, 2000, Journal of Virology.

Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin

A. Engelman, P. Cherepanov, G. Maertens, 2006, Journal of Cell Science.

Structural insights into the retroviral DNA integration apparatus.

P. Cherepanov, G. Maertens, S. Hare, 2011, Current opinion in structural biology.

Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase

R. Benarous, V. E. Pye, P. Cherepanov, 2023, Antimicrobial agents and chemotherapy.

Multivalent interactions essential for lentiviral integrase function

A. Engelman, I. Taylor, N. Cook, 2022, Nature Communications.

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p 75

A. Engelman, T. Ellenberger, P. Cherepanov, 2005 .

Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir ( S / GSK 1349572 )

Y. Pommier, S. Hughes, P. Cherepanov, 2011 .

Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir

Yves Pommier, Stephen H. Hughes, Y. Pommier, 2011 .

Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

S. Hughes, V. E. Pye, P. Cherepanov, 2021, Nature Communications.

Retroviral Integrase Structure and DNA Recombination Mechanism.

A. Engelman, P. Cherepanov, 2014, Microbiology spectrum.

Structural basis for nuclear import of splicing factors by human Transportin 3

A. Engelman, N. Cook, A. Fassati, 2014, Proceedings of the National Academy of Sciences of the United States of America.

Solution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA.

F. Bushman, S. Krueger, J. E. Curtis, 2012, Structure.

Integrase illuminated

P. Cherepanov, 2010, EMBO reports.