A. Newman

发表

Time-resolved FRET between GPCR ligands reveals oligomers in native tissues.

J. Javitch, J. Pin, I. Brabet, 2010, Nature chemical biology.

Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor.

J. Deschamps, Lei Shi, J. Javitch, 2017, Journal of medicinal chemistry.

Tyr-95 and Ile-172 in Transmembrane Segments 1 and 3 of Human Serotonin Transporters Interact to Establish High Affinity Recognition of Antidepressants*

R. Blakely, J. Field, A. Newman, 2006, Journal of Biological Chemistry.

Effects of selective dopaminergic compounds on a delay-discounting task

Mikhail N. Koffarnus, A. Newman, K. Rice, 2011, Behavioural pharmacology.

Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents.

M. Nader, A. Newman, P. Grundt, 2005, Journal of medicinal chemistry.

The binding sites for cocaine and dopamine in the dopamine transporter overlap

H. Weinstein, Lei Shi, J. Javitch, 2008, Nature Neuroscience.

A dominant-negative variant in the dopamine transporter PDZ-binding motif is linked to parkinsonism and neuropsychiatric disease

T. Werge, A. Galli, A. Newman, 2020 .

2D QSAR modeling and preliminary database searching for dopamine transporter inhibitors using genetic algorithm variable selection of Molconn Z descriptors.

J L Katz, B. Hoffman, A. Newman, 2000, Journal of medicinal chemistry.

Influence of Cocaine History on the Behavioral Effects of Dopamine D3 Receptor-Selective Compounds in Monkeys

M. Nader, A. Newman, P. Grundt, 2012, Neuropsychopharmacology.

AHN 086: an irreversible ligand of "peripheral" benzodiazepine receptors.

P. Skolnick, A. Newman, K. Rice, 1986, Molecular pharmacology.

Dopamine Agonist-Induced Yawning in Rats: A Dopamine D3 Receptor-Mediated Behavior

A. Newman, J. Witkin, J. Woods, 2005, Journal of Pharmacology and Experimental Therapeutics.

Yawning and locomotor behavior induced by dopamine receptor agonists in mice and rats

D. Grandy, A. Newman, J. Woods, 2010, Behavioural pharmacology.

Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol.

Noel M. Paul, Robert R Luedtke, Michelle Taylor, 2008, Journal of medicinal chemistry.

Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists.

A. Newman, S. Kulkarni, 2007, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonists.

A. Newman, S. Kulkarni, 2007, Bioorganic & medicinal chemistry letters.

Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists.

A. Newman, R. Rothman, C. Dersch, 2006, Bioorganic & medicinal chemistry letters.

Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5.

A. Newman, P. Conn, M. Zou, 2011, Bioorganic & medicinal chemistry letters.

Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.

A. Newman, P. Conn, M. Zou, 2010, Bioorganic & medicinal chemistry.

Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans

Z. Xi, A. Newman, Thomas M. Keck, 2013, Psychopharmacology.

Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation.

A. Newman, Thomas M. Keck, M. Zou, 2012, ACS medicinal chemistry letters.

Cocaine analogue conjugated magnetic nanoparticles for labeling and imaging dopaminergic neurons.

Miqin Zhang, D. Martínez, A. Newman, 2020, Biomaterials science.

Allosterically Linked Binding Sites in Serotonin Transporter Revealed by Single Molecule Force Spectroscopy

H. Sitte, A. Newman, M. Freissmuth, 2020, Frontiers in Molecular Biosciences.

Targeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter

M. H. Cheng, I. Bahar, A. Newman, 2017, Scientific Reports.

Labeling of Dopamine Transporter Transmembrane Domain 1 with the Tropane Ligand N-[4-(4-Azido-3-[125I]iodophenyl)butyl]-2β-carbomethoxy-3β-(4-chlorophenyl)tropane Implicates Proximity of Cocaine and Substrate Active Sites

A. Newman, R. Vaughan, M. L. Parnás, 2008, Molecular Pharmacology.

MOL # 43679 1 LABELING OF DOPAMINE TRANSPORTER TRANSMEMBRANE DOMAIN 1 WITH THE TROPANE LIGAND [ 125 I ] MFZ 2-24 IMPLICATES PROXIMITY OF COCAINE AND SUBSTRATE ACTIVE SITES

A. Newman, R. Vaughan, M. L. Parnás, 2008 .

Differential effects of the dopamine D3 receptor antagonist PG01037 on cocaine and methamphetamine self-administration in rhesus monkeys

M. Nader, A. Newman, W. S. John, 2015, Neuropharmacology.

Medicinal Chemistry: New Chemical Classes and Subtype-Selective Ligands

A. Newman, A. Coop, 2007 .

Cocaine and several σ receptor ligands inhibit dopamine uptake in rat caudate-putamen

A. Newman, J. Katz, S. Izenwasser, 1993 .

Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole): irreversible ligands for the dopamine transporter.

W. Bowen, A. Newman, S. Husbands, 1997, Journal of medicinal chemistry.

Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues.

W. Bowen, A. Newman, S. Husbands, 1999, Journal of medicinal chemistry.

Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis

P. W. Czoty, M. Nader, A. Newman, 2015, Journal of medicinal chemistry.

Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug design.

Lei Shi, A. Newman, Thomas M. Keck, 2014, Advances in pharmacology.

N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists.

Robert R Luedtke, Peter Grundt, Michelle Taylor, 2009, Journal of medicinal chemistry.

Novel Dual-Target μ-Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management.

V. Katritch, A. Newman, Alessandro Bonifazi, 2021, Journal of medicinal chemistry.

Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66.

A. Newman, Alessandro Bonifazi, Thomas M. Keck, 2014, ACS medicinal chemistry letters.

Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites.

A. Newman, P. Plenge, C. Loland, 2013, Journal of medicinal chemistry.

Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype.

A. Newman, S. Husbands, A. Thurkauf, 2001, Journal of medicinal chemistry.

Applicability of the Dopamine and Rate Hypotheses in Explaining the Differences in Behavioral Pharmacology of the Chloro-Benztropine Analogs: Studies Conducted Using Intracerebral Microdialysis and Population Pharmacodynamic Modeling

A. Newman, N. Eddington, Ahmed A. Othman, 2007, Journal of Pharmacology and Experimental Therapeutics.

Precursors of the mammalian synthesis of morphine: (+)‐salutaridine and (−)‐thebaine from (+)‐6‐demethylsalutaridine, and (−)‐N‐13CH3‐thebaine from (−)‐northebaine

A. Brossi, A. Newman, K. Rice, 1986, FEBS letters.

A novel mGluR 5 antagonist , MFZ 10-7 , inhibits cocaine-taking and cocaine-seeking behavior in rats

Z. Xi, A. Newman, Thomas M. Keck, 2019 .

A novel mGluR5 antagonist, MFZ 10‐7, inhibits cocaine‐taking and cocaine‐seeking behavior in rats

Z. Xi, A. Newman, Thomas M. Keck, 2014, Addiction biology.

Atypical dopamine transporter inhibitors R-modafinil and JHW 007 differentially affect D2 autoreceptor neurotransmission and the firing rate of midbrain dopamine neurons

A. Newman, Jianjing Cao, M. Beckstead, 2017, Neuropharmacology.

Dopamine D3 Receptors Mediate the Discriminative Stimulus Effects of Quinpirole in Free-Feeding Rats

A. Newman, C. France, M. Baladi, 2010, Journal of Pharmacology and Experimental Therapeutics.

(+/-)-3-[4'-(N,N-dimethylamino)cinnamyl]benzazepine analogs: novel dopamine D1 receptor antagonists.

R. H. Kline, A. Newman, J. Witkin, 1996, Journal of medicinal chemistry.

The highly selective dopamine D 3 R antagonist, R-VK4-40 attenuates oxycodone reward and augments analgesia in rodents

Z. Xi, A. Newman, C. Jordan, 2019, Neuropharmacology.

The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor.

A. Newman, P. Grundt, T. Kopajtic, 2004, Bioorganic & medicinal chemistry letters.

Structure−Activity Relationship Comparison of ( S )-2β-Substituted 3α-(Bis[4-fluorophenyl]methoxy)tropanes and ( R )-2β-Substituted 3β-(3,4-Dichlorophenyl)tropanes at the Dopamine Transporter

A. Newman, M. Zou, T. Kopajtic, 2003 .

Evaluation of the Blood-Brain Barrier Transport, Population Pharmacokinetics, and Brain Distribution of Benztropine Analogs and Cocaine Using in Vitro and in Vivo Techniques

A. Newman, Jianjing Cao, N. Eddington, 2003, Journal of Pharmacology and Experimental Therapeutics.

[3H]MFZ 2-12: a novel radioligand for the dopamine transporter.

J. Javitch, A. Newman, M. Zou, 2001, Bioorganic & medicinal chemistry letters.

[3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter.

A. Newman, S. Husbands, T. Kopajtic, 2001, Bioorganic & medicinal chemistry letters.

Relations between stimulation of mesolimbic dopamine and place conditioning in rats produced by cocaine or drugs that are tolerant to dopamine transporter conformational change

A. Newman, G. Tanda, M. Zou, 2013, Psychopharmacology.

Dopaminergic regulation of dopamine D3 and D3nf receptor mRNA expression

A. Newman, Yanhong Liu, R. McNamara, 2010, Synapse.

The novel N-substituted benztropine analog GA2-50 possesses pharmacokinetic and pharmacodynamic profiles favorable for a candidate substitute medication for cocaine abuse.

A. Newman, N. Eddington, Ahmed A. Othman, 2008, Journal of pharmaceutical sciences.

Transport, Metabolism, and in Vivo Population Pharmacokinetics of the Chloro Benztropine Analogs, a Class of Compounds Extensively Evaluated in Animal Models of Drug Abuse

A. Newman, N. Eddington, Ahmed A. Othman, 2007, Journal of Pharmacology and Experimental Therapeutics.

Synthesis and evaluation of a novel series of 2-chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-3-(2-(4-pyridinyl)vinyl)pyridine analogues as potential positron emission tomography imaging agents for nicotinic acetylcholine receptors.

A. Horti, A. Newman, A. Mukhin, 2002, Journal of medicinal chemistry.

Purification of the putative hormone-sensitive cyclic AMP phosphodiesterase from rat adipose tissue using a derivative of cilostamide as a novel affinity ligand.

A. Newman, E. Degerman, V. Manganiello, 1987, The Journal of biological chemistry.

A highly D3R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D3R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder

A. Janowsky, Z. Xi, A. Newman, 2022, Neuropsychopharmacology.

Decreases in Cocaine Self-Administration with Dual Inhibition of the Dopamine Transporter and σ Receptors

A. Newman, P. Soto, G. Tanda, 2011, Journal of Pharmacology and Experimental Therapeutics.

Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach

Williams E. Miranda, Lei Shi, H. Duff, 2019, J. Chem. Inf. Model..

Dopamine D3R antagonist VK4-116 attenuates oxycodone self-administration and reinstatement without compromising its antinociceptive effects

Z. Xi, A. Newman, Vivek Kumar, 2018, Neuropsychopharmacology.

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.

Thorvald F. Andreassen, H. Weinstein, H. Sitte, 2014, The Journal of clinical investigation.

Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity

M. Sauer, A. Newman, U. Gether, 2022, bioRxiv.

[O-methyl-11C]N-(4-(4-(3-Chloro-2-methoxyphenyl)-piperazin-1-yl)butyl)-1H-indole-2-carboxamide ([11C]BAK4-51) Is an Efflux Transporter Substrate and Ineffective for PET Imaging of Brain D3 Receptors in Rodents and Monkey

S. Zoghbi, J. Liow, R. Gladding, 2018, Molecules.

Neuroprotection (focal ischemia) and neurotoxicity (electroencephalographic) studies in rats with AHN649, a 3-amino analog of dextromethorphan and low-affinity N-methyl-D-aspartate antagonist.

X. C. Lu, F. Tortella, A. Newman, 1999, The Journal of pharmacology and experimental therapeutics.

Methylphenidate Analogues as a New Class of Potential Disease-Modifying Agents for Parkinson’s Disease: Evidence from Cell Models and Alpha-Synuclein Transgenic Mice

A. Newman, A. Gianoncelli, G. Ribaudo, 2022, Pharmaceutics.

A highly D3R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D3R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder

A. Janowsky, Z. Xi, A. Newman, 2022, Neuropsychopharmacology.

Illuminating the norepinephrine transporter: fluorescent probes based on nisoxetine and talopram.

H. Sitte, G. Schütz, A. Newman, 2021, RSC medicinal chemistry.

Elucidation of Structural Elements for Selectivity across Monoamine Transporters: Novel 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues

A. Newman, C. Loland, T. Kopajtic, 2014, Journal of medicinal chemistry.

Pro-erectile Effects of Dopamine D 2 -like Agonists are Mediated by the D 3 Receptor in Rats and Mice

D. Grandy, Jianyong Chen, A. Newman, 2008 .

Dopamine Transporter-Dependent and -Independent Striatal Binding of the Benztropine Analog JHW 007, a Cocaine Antagonist with Low Abuse Liability

A. Newman, C. K. Surratt, D. Donovan, 2010, Journal of Pharmacology and Experimental Therapeutics.

Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites.

H. Sitte, T. Stockner, A. Newman, 2016, Angewandte Chemie.

Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters.

J. Javitch, A. Newman, Yongfang Zhao, 2010, Journal of medicinal chemistry.

The cocaine-like behavioral effects of meperidine are mediated by activity at the dopamine transporter.

A. Newman, B. Cox, J. Katz, 1996, European journal of pharmacology.

Hormonal regulation of adipocyte particulate "low Km" cAMP phosphodiesterase.

A. Newman, E. Degerman, V. Manganiello, 1986, Journal of cyclic nucleotide and protein phosphorylation research.

AHN649: Preclinical Evaluation of a Novel Anticonvulsant and Neuroprotective Analog of Dextromethorphan

F. Tortella, A. Newman, P. Britton, 1997 .

Evaluation of the D3 dopamine receptor selective antagonist PG01037 on l-dopa-dependent abnormal involuntary movements in rats

A. Newman, P. Grundt, R. Luedtke, 2009, Neuropharmacology.

Attenuation of the stimulant and convulsant effects of cocaine by 17-substituted-3-hydroxy and 3-alkoxy derivatives of dextromethorphan

F. Tortella, A. Zapata, A. Newman, 2003, Pharmacology Biochemistry and Behavior.

(±)VK4‐40, a novel dopamine D3 receptor partial agonist, attenuates cocaine reward and relapse in rodents

Z. Xi, A. Newman, C. Jordan, 2020, British journal of pharmacology.

Yawning elicited by intravenous ethanol in rhesus monkeys with experience self-administering cocaine and ethanol: Involvement of dopamine D3 receptors.

M. Nader, A. Newman, P. Czoty, 2017, Alcohol.

Purification of a cGMP-inhibited cAMP Phosphodiesterase from Vascular Smooth Muscle

A. Newman, E. Degerman, V. Manganiello, 1990 .

Characterization of the effects of AHN 086, an irreversible ligand of "peripheral" benzodiazepine receptors, on contraction in guinea-pig atrial and ileal longitudinal smooth muscle.

P. Skolnick, A. Newman, K. Rice, 1989, Canadian journal of physiology and pharmacology.

Phosphatidylinositol 4,5-bisphosphate (PIP2) facilitates norepinephrine transporter dimerization and modulates substrate efflux

H. Sitte, M. Brameshuber, G. Schütz, 2022, Communications Biology.

A tropane-based ibogaine analog rescues folding-deficient SERT and DAT

T. Hummel, A. Newman, M. Freissmuth, 2020, bioRxiv.

Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram.

A. Newman, U. Gether, Vivek Kumar, 2014, ACS medicinal chemistry letters.

Postendocytic Sorting of Constitutively Internalized Dopamine Transporter in Cell Lines and Dopaminergic Neurons*

A. Newman, U. Gether, T. N. Jørgensen, 2010, The Journal of Biological Chemistry.

Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter.

R. H. Kline, A. Newman, J. Katz, 1997, Journal of medicinal chemistry.

Novel 4'-substituted and 4',4"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs as potent and selective dopamine uptake inhibitors.

R. H. Kline, A. Newman, J. Katz, 1995, Journal of medicinal chemistry.

What Can Crystal Structures of Aminergic Receptors Tell Us about Designing Subtype-Selective Ligands?

Lei Shi, Thijs Beuming, Mayako Michino, 2015, Pharmacological Reviews.

Behavioral effects of rimcazole analogues alone and in combination with cocaine.

A. Newman, S. Husbands, T. Kopajtic, 2003, European journal of pharmacology.

Behavioral effects and dopamine antagonist properties of N‐alkylaminobenzazepines

A. Newman, J. Witkin, A. Basile, 1996 .

Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine

Z. Xi, A. Newman, C. Jordan, 2019, Neuropharmacology.

Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders.

Ara M. Abramyan, Lei Shi, A. Newman, 2017, Journal of medicinal chemistry.

N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands.

A. Newman, P. Grundt, T. Kopajtic, 2005, Bioorganic & medicinal chemistry letters.

Three-dimensional quantitative structure-activity relationships of mazindol analogues at the dopamine transporter.

A. Newman, S. Kulkarni, W. Houlihan, 2002, Journal of Medicinal Chemistry.

Relations Between Heterogeneity of Dopamine Transporter Binding and Function and the Behavioral Pharmacology of Cocaine

A. Newman, J. Katz, S. Izenwasser, 1997, Pharmacology Biochemistry and Behavior.

Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter.

S. Rasmussen, A. Newman, U. Gether, 2005, Journal of medicinal chemistry.

Novel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram

A. Newman, R. Vaughan, Vivek Kumar, 2015, Journal of medicinal chemistry.

Highly selective chiral N-substituted 3alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues for the dopamine transporter: synthesis and comparative molecular field analysis.

A. Newman, T. Kopajtic, J. Katz, 2000, Journal of medicinal chemistry.

Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity

D. Sibley, A. Janowsky, Lei Shi, 2016, Journal of Medicinal Chemistry.

R-Modafinil (Armodafinil): A Unique Dopamine Uptake Inhibitor and Potential Medication for Psychostimulant Abuse

Lei Shi, A. Newman, C. Loland, 2012, Biological Psychiatry.

SARs at the Monoamine Transporters for a Novel Series of Modafinil Analogues

A. Newman, T. Prisinzano, T. Kopajtic, 2011 .

Chiral aminophosphonate eluent for enantiomeric analysis of amino acids.

A. Newman, A. Y. Aksinenko, B. Blessington, 1996, Chirality.

Structure-Activity Relationships for a series of bis(4-fluorophenyl)methyl)sulfinyl)alkyl alicyclic amines at the dopamine transporter: functionalizing the terminal nitrogen affects affinity, selectivity and metabolic stability.

A. Newman, Alessandro Bonifazi, C. Loland, 2019, Journal of medicinal chemistry.

Relationship between Conformational Changes in the Dopamine Transporter and Cocaine-Like Subjective Effects of Uptake Inhibitors

H. Sitte, A. Newman, U. Gether, 2008, Molecular Pharmacology.

Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR.

Robert R Luedtke, Peter Grundt, Michelle Taylor, 2007, Bioorganic & medicinal chemistry letters.

Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype.

A. Abeliovich, A. Newman, U. Gether, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands.

J. Deschamps, A. Newman, Alessandro Bonifazi, 2015, Bioorganic & medicinal chemistry.

The potent opioid agonist, (+)-cis-3-methylfentanyl binds pseudoirreversibly to the opioid receptor complex in vitro and in vivo: evidence for a novel mechanism of action.

N. Greig, A. Newman, K. Rice, 1990, Life sciences.

The unique psychostimulant profile of (±)‐modafinil: investigation of behavioral and neurochemical effects in mice

A. Newman, T. Prisinzano, G. Tanda, 2017, The European journal of neuroscience.

The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders

A. Bonci, A. Newman, G. Tanda, 2013, Psychopharmacology.

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

Jonathan A. Javitch, Lei Shi, Raymond C. Stevens, 2010, Science.

Release of Ca2+ from heart and kidney mitochondria by peripheral-type benzodiazepine receptor ligands.

R. Moreno-Sánchez, P. Chiang, A. Newman, 1991, The International journal of biochemistry.

Synthesis and evaluation of 3-substituted 17-methylmorphinan analogs as potential anticonvulsant agents.

F. Tortella, N. Bowery, A. Newman, 1992, Journal of medicinal chemistry.

Stereospecific reversal of nitrous oxide analgesia by naloxone.

P. Skolnick, A. Newman, K. Rice, 1989, Life sciences.

Probes for the dopamine transporter: New leads toward a cocaine‐abuse therapeutic—A focus on analogues of benztropine and rimcazole

A. Newman, S. Kulkarni, 2002, Medicinal research reviews.

Differential Binding of Tropane-Based Photoaffinity Ligands on the Dopamine Transporter

A. Newman, R. Vaughan, J. Lever, 1999, The Journal of Neuroscience.

Novel 3alpha-diphenylmethoxytropane analogs: selective dopamine uptake inhibitors with behavioral effects distinct from those of cocaine.

R. H. Kline, A. Newman, J. Katz, 1999, The Journal of pharmacology and experimental therapeutics.

Novel 3 alpha-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioral profiles.

A. Newman, J. Katz, A. Allen, 1994, Journal of medicinal chemistry.

Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders

Ara M. Abramyan, Z. Xi, Lei Shi, 2019, Neuropsychopharmacology.

Selective D2 and D3 receptor antagonists oppositely modulate cocaine responses in mice via distinct postsynaptic mechanisms in nucleus accumbens

Kirsten A. Porter-Stransky, C. Paladini, G. Miller, 2018, bioRxiv.

The novel dopamine D3 receptor antagonists/partial agonists CAB2-015 and BAK4-54 inhibit oxycodone-taking and oxycodone-seeking behavior in rats

Z. Xi, A. Newman, Guo-hua Bi, 2017, Neuropharmacology.

Modafinil potentiates cocaine self-administration by a dopamine-independent mechanism: possible involvement of gap junctions

Z. Xi, A. Newman, C. Jordan, 2020, Neuropsychopharmacology.

Distinct effects of (R)‐modafinil and its (R)‐ and (S)‐fluoro‐analogs on mesolimbic extracellular dopamine assessed by voltammetry and microdialysis in rats

A. Newman, G. Tanda, Jacqueline Keighron, 2018, The European journal of neuroscience.

The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic

Z. Xi, A. Newman, G. Tanda, 2017, Neuropsychopharmacology.

Chapter 29. Irreversible Ligands for Drug Receptor Characterization

A. Newman, 1990 .

Interaction of enantiomeric pairs of opiates with phencyclidine binding sites in rat brain: Identification of (+) pentazocine as a ligand potentially suitable for imaging sigma binding sites using positron emission tomography

A. Newman, K. Rice, R. Rothman, 1988, Neuropeptides.

Medication discovery for addiction: translating the dopamine D3 receptor hypothesis.

D. Sibley, M. Nader, P. Skolnick, 2012, Biochemical pharmacology.

Inhibition of substrate oxidation in mitochondria by the peripheral-type benzodiazepine receptor ligand AHN 086.

R. Moreno-Sánchez, P. Chiang, A. Newman, 1991, Biochemical pharmacology.

Radioiodinated azide and isothiocyanate derivatives of cocaine for irreversible labeling of dopamine transporters: synthesis and covalent binding studies.

J. B. Justice, A. Newman, R. Vaughan, 2005, Bioconjugate chemistry.

PG01037, a novel dopamine D3 receptor antagonist, inhibits the effects of methamphetamine in rats

Z. Xi, A. Newman, P. Grundt, 2011, Journal of psychopharmacology.

Neurochemical and behavioral comparisons of contingent and non-contingent methamphetamine exposure following binge or yoked long-access self-administration paradigms

J. Cadet, Z. Xi, H. van Praag, 2020, Psychopharmacology.

Acute administration of SB‐277011A, NGB 2904, or BP 897 inhibits cocaine cue‐induced reinstatement of drug‐seeking behavior in rats: Role of dopamine D3 receptors

Z. Xi, A. Newman, C. Heidbreder, 2005, Synapse.

PET imaging of opiate receptor binding in human epilepsy using [18F]cyclofoxy

Peter Herscovitch, Michael Channing, Richard E. Carson, 1992, Epilepsy Research.

Effects of buspirone and the dopamine D3 receptor compound PG619 on cocaine and methamphetamine self-administration in rhesus monkeys using a food-drug choice paradigm

M. Nader, A. Newman, A. Banala, 2015, Psychopharmacology.

Kinetic analysis of the opiate antagonist cyclofoxy in rat brain: simultaneous infusion of active and inactive enantiomers.

R. Blasberg, Y. Sawada, A. Newman, 1990, The Journal of pharmacology and experimental therapeutics.

Effects of Muscarinic M1 Receptor Blockade on Cocaine-Induced Elevations of Brain Dopamine Levels and Locomotor Behavior in Rats

A. Newman, G. Tanda, T. Kopajtic, 2007, Journal of Pharmacology and Experimental Therapeutics.

Novel and Potent Dopamine D2 Receptor Go-Protein Biased Agonists

A. Hoffman, C. Lupica, Lei Shi, 2019, ACS pharmacology & translational science.

Methylphenidate modifies the motion of the circadian clock Lamotrigine in mood disorders and cocaine dependence Cortical glutamate in postpartum depression The Novel Modafinil Analog , JJC 8-016 , as a Potential Cocaine Abuse Pharmacotherapeutic

Z. Xi, A. Newman, G. Tanda, 2017 .

The Novel Dopamine D3 Receptor Antagonist NGB 2904 Inhibits Cocaine's Rewarding Effects and Cocaine-Induced Reinstatement of Drug-Seeking Behavior in Rats

L. Gitajn, Z. Xi, A. Newman, 2006, Neuropsychopharmacology.

Computation-guided analysis of paroxetine binding to hSERT reveals functionally important structural elements and dynamics

Ara M. Abramyan, Lei Shi, A. Newman, 2019, Neuropharmacology.

A novel Bromine-containing paroxetine analog provides mechanistic clues for binding ambiguity at the central primary binding site of the serotonin transporter.

Ara M. Abramyan, J. Deschamps, Lei Shi, 2019, ACS chemical neuroscience.

Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease

T. Werge, A. Galli, A. Newman, 2021, JCI insight.

Highly selective σ1 ligands based on dextromethorphan

F. Tortella, A. Newman, S. Izenwasser, 1996 .

N-Substituted-3-alkoxy-derivatives of dextromethorphan are functional NMDA receptor antagonists in vivo: Evidence from an NMDA-induced seizure model in rats

Jodi L. Smith, F. Tortella, A. Newman, 2021, Pharmacology, Biochemistry and Behavior.

Effects of the selective dopamine D3 receptor antagonist PG01037 on morphine-induced hyperactivity and antinociception in mice

Z. Xi, A. Newman, D. Weinshenker, 2020, Behavioural Brain Research.

Current perspectives on selective dopamine D3 receptor antagonists as pharmacotherapeutics for addictions and related disorders

A. Newman, C. Heidbreder, Christian A Heidbreder, 2010, Annals of the New York Academy of Sciences.

Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats

L. Dwoskin, P. Crooks, M. Bardo, 2018, Psychopharmacology.

Further Characterization of Quinpirole-Elicited Yawning as a Model of Dopamine D3 Receptor Activation in Male and Female Monkeys

M. Nader, A. Newman, P. Garg, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Place Conditioning and Locomotor Effects of N-Substituted, 4′,4′′-Difluorobenztropine Analogs in Rats

A. Newman, J. Katz, Su-min Li, 2005, Journal of Pharmacology and Experimental Therapeutics.

Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini*

M. Scheinin, A. Newman, U. Gether, 2016, The Journal of Biological Chemistry.

Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D2/D3 Receptor Bitopic Ligands.

Lei Shi, A. Newman, Alessandro Bonifazi, 2021, Journal of medicinal chemistry.

2-Isoxazol-3-Phenyltropane Derivatives of Cocaine: Molecular and Atypical System Effects at the Dopamine Transporter

C. Lupica, A. Newman, P. Soto, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Assessment of Reinforcing Effects of Benztropine Analogs and Their Effects on Cocaine Self-Administration in Rats: Comparisons with Monoamine Uptake Inhibitors

A. Newman, P. Soto, J. Katz, 2009, Journal of Pharmacology and Experimental Therapeutics.

Relationship between in Vivo Occupancy at the Dopamine Transporter and Behavioral Effects of Cocaine, GBR 12909 [1-{2-[Bis-(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine], and Benztropine Analogs

A. Newman, T. Kopajtic, J. Katz, 2005, Journal of Pharmacology and Experimental Therapeutics.

Effects of N-Substituted Analogs of Benztropine: Diminished Cocaine-Like Effects in Dopamine Transporter Ligands

A. Newman, T. Kopajtic, J. Katz, 2004, Journal of Pharmacology and Experimental Therapeutics.

Identification of the benztropine analog [125I]GA II 34 binding site on the human dopamine transporter

A. Newman, R. Vaughan, A. Pramod, 2019, Neurochemistry International.

Computational and Biochemical Docking of the Irreversible Cocaine Analog RTI 82 Directly Demonstrates Ligand Positioning in the Dopamine Transporter Central Substrate-binding Site*

A. Newman, J. Foster, R. Vaughan, 2014, The Journal of Biological Chemistry.

Dopamine D4 Receptor-Selective Compounds Reveal Structure–Activity Relationships that Engender Agonist Efficacy

D. Sibley, Chun Wu, A. Newman, 2019, Journal of medicinal chemistry.

Drinking sucrose enhances quinpirole-induced yawning in rats

A. Newman, C. France, M. Baladi, 2011, Behavioural pharmacology.

New Drugs, Old Targets: Tweaking the Dopamine System to Treat Psychostimulant Use Disorders.

Z. Xi, A. Newman, C. Jordan, 2021, Annual review of pharmacology and toxicology.

Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays

Ara M. Abramyan, Lei Shi, A. Newman, 2018, Neuropharmacology.

Structure-activity relationships for a series of (Bis(4-fluorophenyl)methyl)sulfinylethyl-aminopiperidines and -piperidine amines at the dopamine transporter: Bioisosteric replacement of the piperazine improves metabolic stability.

A. Newman, Alessandro Bonifazi, G. Tanda, 2020, European journal of medicinal chemistry.

Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters

T. Hummel, A. Newman, M. Freissmuth, 2020, ACS pharmacology & translational science.

How to rescue misfolded SERT, DAT and NET: targeting conformational intermediates with atypical inhibitors and partial releasers

A. Newman, M. Freissmuth, Shreyas Bhat, 2019, Biochemical Society transactions.

Tranylcypromine Substituted cis-Hydroxycyclobutylnaphthamides as Potent and Selective Dopamine D3 Receptor Antagonists

Shaomeng Wang, Jianyong Chen, A. Newman, 2014, Journal of medicinal chemistry.

σ Receptors negatively modulate agonist-stimulated phosphoinositide metabolism in rat brain

W. Bowen, A. Newman, K. Rice, 1988 .

Newly Developed Dopamine D3 Receptor Antagonists, R-VK4-40 and R-VK4-116, Do Not Potentiate Cardiovascular Effects of Cocaine or Oxycodone in Rats

Z. Xi, E. Thorndike, A. Newman, 2019, The Journal of Pharmacology and Experimental Therapeutics.

2016 Philip S. Portoghese Medicinal Chemistry Lectureship: Designing Bivalent or Bitopic Molecules for G-protein Coupled Receptors - The Whole is Greater Than the Sum of its Parts.

A. Newman, Alessandro Bonifazi, Francisco O. Battiti, 2019, Journal of medicinal chemistry.

Investigation of novel primary and secondary pharmacophores, and 3-substitution in the linking chain of a series of highly selective and bitopic dopamine D3 receptor antagonists and partial agonists.

Z. Xi, A. Newman, Alessandro Bonifazi, 2019, Journal of medicinal chemistry.

The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D3 Receptor (D3R) Selective Agonists.

A. Newman, Alessandro Bonifazi, Gregory H. Imler, 2019, Journal of medicinal chemistry.

6.07 – Addiction

A. Newman, R. Rothman, 2007 .

Targeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter

M. H. Cheng, I. Bahar, A. Newman, 2017, Scientific Reports.

Dopamine D3 receptor-based medication development for the treatment of opioid use disorder: Rationale, progress, and challenges

Z. Xi, A. Newman, E. Galaj, 2020, Neuroscience & Biobehavioral Reviews.

The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity

N. Volkow, M. Michaelides, P. Thanos, 2008, Pharmacology Biochemistry and Behavior.

Evaluation of the D3 dopamine receptor selective agonist/partial agonist PG01042 on l-dopa dependent animal involuntary movements in rats

A. Newman, P. Grundt, R. Luedtke, 2011, Neuropharmacology.

Imaging brain regional and cortical laminar effects of selective D3 agonists and antagonists

Susanta K. Sarkar, Joseph B. Mandeville, Ji-Kyung Choi, 2010, Psychopharmacology.

Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists

Shaomeng Wang, Jianyong Chen, A. Newman, 2007, Psychopharmacology.

Proerectile Effects of Dopamine D2-Like Agonists Are Mediated by the D3 Receptor in Rats and Mice

D. Grandy, Shaomeng Wang, R. Sunahara, 2009, Journal of Pharmacology and Experimental Therapeutics.

Psychostimulant Use Disorder, an Unmet Therapeutic Goal: Can Modafinil Narrow the Gap?

A. Newman, L. Leggio, G. Tanda, 2021, Frontiers in Neuroscience.

Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters

W. Bowen, A. Newman, S. Husbands, 2001, Neuropharmacology.

Characterization of the Transport, Metabolism, and Pharmacokinetics of the Dopamine D3 Receptor-Selective Fluorenyl- and 2-Pyridylphenyl Amides Developed for Treatment of Psychostimulant Abuse

A. Newman, Kang-Pil Kim, P. Voulalas, 2010, Journal of Pharmacology and Experimental Therapeutics.

Behavioral and neurochemical effects of the dopamine transporter ligand 4-chlorobenztropine alone and in combination with cocaine in vivo.

A. Newman, J. Katz, S. Berger, 1999, The Journal of pharmacology and experimental therapeutics.

Effects of the selective dopamine D3 receptor antagonist PG01037 on morphine-induced hyperactivity and antinociception in mice

Z. Xi, A. Newman, D. Weinshenker, 2020, Behavioural Brain Research.

Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H(1) receptors.

A. Newman, T. Kopajtic, J. Katz, 2006, Bioorganic & medicinal chemistry.

Dopamine D3 receptor selective ligands with varying intrinsic efficacies at adenylyl cyclase inhibition and mitogenic signaling pathways

A. Newman, P. Grundt, R. Luedtke, 2010, Synapse.

Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter.

J. Javitch, Brian T DeVree, J. Grimm, 2020, ACS chemical neuroscience.

Dopamine D3 Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats

A. Newman, O. George, G. de Guglielmo, 2020, Frontiers in Behavioral Neuroscience.

R-Modafinil Attenuates Nicotine-Taking and Nicotine-Seeking Behavior in Alcohol-Preferring Rats

Z. Xi, A. Newman, Guo-hua Bi, 2015, Neuropsychopharmacology.

Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors.

A. Newman, G. Tanda, J. Katz, 2009, Advances in pharmacology.

The N Terminus of Monoamine Transporters Is a Lever Required for the Action of Amphetamines*

Barbara Zdrazil, Gerhard F. Ecker, Harald H. Sitte, 2010, The Journal of Biological Chemistry.

Influence of body weight and type of chow on the sensitivity of rats to the behavioral effects of the direct-acting dopamine-receptor agonist quinpirole

A. Newman, C. France, M. Baladi, 2011, Psychopharmacology.

Novel pharmacotherapies for cocaine abuse 1997 - 2000

A. Newman, 2000 .

Probing Binding Pocket of Serotonin Transporter by Single Molecular Force Spectroscopy on Living Cells*

H. Sitte, A. Newman, M. Freissmuth, 2011, The Journal of Biological Chemistry.

Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction.

A. Newman, R. Rothman, T. Prisinzano, 2008, Biochemical pharmacology.

Food Restriction Alters N′-Propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (Pramipexole)-Induced Yawning, Hypothermia, and Locomotor Activity in Rats: Evidence for Sensitization of Dopamine D2 Receptor-Mediated Effects

D. Calinski, A. Newman, J. Woods, 2008, Journal of Pharmacology and Experimental Therapeutics.

Effects of selective dopamine D3 receptor partial agonist/antagonists on oxycodone self-administration and antinociception in monkeys

M. Nader, A. Newman, M. Banks, 2023, Neuropsychopharmacology.

Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents.

W. Bowen, C. George, A. Newman, 2003, Journal of medicinal chemistry.

Cocaine self-administration in dopamine D₃ receptor knockout mice.

A. Newman, P. Grundt, Morgane Thomsen, 2012, Experimental and clinical psychopharmacology.

Dopamine D3/D2 Receptor Ligands Based on Cariprazine for the Treatment of Psychostimulant Use Disorders That May Be Dual Diagnosed with Affective Disorders.

J. R. Lane, Z. Xi, A. Newman, 2023, Journal of medicinal chemistry.

Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.

Zheng-Xiong Xi, Alessandro Bonifazi, Rana Rais, 2016, Journal of medicinal chemistry.

Probes for the Dopamine Transporter: New Leads Toward a Cocaine‐Abuse Therapeutic — A Focus on Analogues of Benztropine and Rimcazole

A. Newman, S. Kulkarni, 2002 .

Influence of Cocaine History on the Behavioral Effects of Dopamine D3 Receptor-Selective Compounds in Monkeys

M. Nader, A. Newman, P. Grundt, 2011, Neuropsychopharmacology.

Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D2 Receptor (D2R) Biased Agonism.

Lei Shi, A. Newman, Alessandro Bonifazi, 2017, Journal of medicinal chemistry.

Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment.

Z. Xi, A. Newman, Alessandro Bonifazi, 2016, Journal of medicinal chemistry.

A Single Glycine in Extracellular Loop 1 Is the Critical Determinant for Pharmacological Specificity of Dopamine D2 and D3 Receptors

Lei Shi, J. Javitch, M. Michino, 2013, Molecular Pharmacology.

Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor.

Erin E. Carlson, Erin E Carlson, Robert R Luedtke, 2005, Journal of medicinal chemistry.

Effects of Two Novel D3-Selective Compounds, NGB 2904 [N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], on the Reinforcing and Discriminative Stimulus Effects of Cocaine in Rhesus M

M. Nader, B. Reboussin, A. Newman, 2007, Journal of Pharmacology and Experimental Therapeutics.

Assessment of the Influence of Histaminergic Actions on Cocaine-Like Effects of 3α-Diphenylmethoxytropane Analogs

A. Newman, T. Kopajtic, J. Katz, 2005, Journal of Pharmacology and Experimental Therapeutics.

Effects of 4′-Chloro-3α-(diphenylmethoxy)-tropane on Mesostriatal, Mesocortical, and Mesolimbic Dopamine Transmission: Comparison with Effects of Cocaine

A. Newman, G. Tanda, J. Katz, 2005, Journal of Pharmacology and Experimental Therapeutics.

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

Lei Shi, J. Javitch, M. Michino, 2012, Journal of medicinal chemistry.

The dopamine D3 receptor partial agonist CJB 090 inhibits the discriminative stimulus but not the reinforcing or priming effects of cocaine in squirrel monkeys

R. Spealman, A. Newman, C. Achat-Mendes, 2009, Psychopharmacology.

Modafinil and its structural analogs as atypical dopamine uptake inhibitors and potential medications for psychostimulant use disorder.

Z. Xi, A. Newman, G. Tanda, 2020, Current opinion in pharmacology.

Dual DAT/sigma1 receptor ligands based on 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol.

A. Newman, T. Kopajtic, J. Katz, 2008, Bioorganic & medicinal chemistry letters.

Atypical Dopamine Uptake Inhibitors that Provide Clues About Cocaine's Mechanism at the Dopamine Transporter

A. Newman, J. Katz, 2008 .

Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes.

A. Newman, T. Kopajtic, J. Katz, 2001, Journal of medicinal chemistry.

Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters

H. Sitte, G. Ecker, T. Stockner, 2016, Molecular Pharmacology.

A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter.

A. Newman, C. Loland, T. N. Jørgensen, 2013, Bioorganic & medicinal chemistry letters.

Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane

A. Newman, L. Henry, M. Zou, 2016, Nature Communications.

Inhibitor mechanisms in the S1 binding site of the dopamine transporter defined by multi‐site molecular tethering of photoactive cocaine analogs

A. Newman, J. Foster, R. Vaughan, 2017, Biochemical pharmacology.

The binding sites for benztropines and dopamine in the dopamine transporter overlap

H. Weinstein, Lei Shi, A. Newman, 2011, Neuropharmacology.

The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats

Z. Xi, A. Newman, C. Heidbreder, 2008, Psychopharmacology.

Steric Hindrance Mutagenesis in the Conserved Extracellular Vestibule Impedes Allosteric Binding of Antidepressants to the Serotonin Transporter*

H. Weinstein, Lei Shi, A. Newman, 2012, The Journal of Biological Chemistry.

Evidence for Noncanonical Neurotransmitter Activation: Norepinephrine as a Dopamine D2-Like Receptor Agonist

S. Ferré, A. Newman, Alessandro Bonifazi, 2016, Molecular Pharmacology.

Single Molecule Analysis Reveals Coexistence of Stable Serotonin Transporter Monomers and Oligomers in the Live Cell Plasma Membrane*

H. Sitte, M. Brameshuber, G. Schütz, 2014, The Journal of Biological Chemistry.

Effects of pramipexole on the reinforcing effectiveness of stimuli that were previously paired with cocaine reinforcement in rats

Shaomeng Wang, Jianyong Chen, A. Newman, 2011, Psychopharmacology.

Visualization of Dopamine Transporter Trafficking in Live Neurons by Use of Fluorescent Cocaine Analogs

S. Rasmussen, C. Vaegter, A. Newman, 2009, The Journal of Neuroscience.

A novel photoaffinity label for the dopamine transporter based on N-substituted 3α-[bis(4′-fluorophenyl)methoxy]tropane

A. Newman, R. Vaughan, J. Lever, 1997 .

Enantioselective synthesis of S-(+)-2β-carboalkoxy-3α-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter

A. Newman, M. Zou, T. Kopajtic, 2002 .

A Novel Photoaffinity Label for the Dopamine Transporter Based on N-Substituted 3α-[Bis(4′-fluorophenyl)methoxy]tropane.

A. Newman, R. Vaughan, J. Lever, 1998 .

3‘-Chloro-3α-(diphenylmethoxy)tropane But Not 4‘-Chloro-3α- (diphenylmethoxy)tropane Produces a Cocaine-like Behavioral Profile†

R. H. Kline, W. Bowen, A. Newman, 1997 .

Role of dopamine D1 receptors in the lethal effects of cocaine and a quaternary methiodide analog.

A. Newman, G. Nowak, J. Witkin, 1993, The Journal of pharmacology and experimental therapeutics.

Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2β-carbomethoxy-3β-biphenyltropane

A. Newman, R. Vaughan, M. L. Parnás, 2006 .

Recognition of Benztropine by the Dopamine Transporter (DAT) Differs from That of the Classical Dopamine Uptake Inhibitors Cocaine, Methylphenidate, and Mazindol as a Function of a DAT Transmembrane 1 Aspartic Acid Residue

A. Newman, A. Kozikowski, C. K. Surratt, 2005, Journal of Pharmacology and Experimental Therapeutics.

Novel tropane-based irreversible ligands for the dopamine transporter.

J. B. Justice, A. Newman, M. Zou, 2001, Journal of medicinal chemistry.

Enantioselective Synthesis of S‐(+)‐2β‐Carboalkoxy‐3α‐[bis(4‐fluorophenyl)methoxy]tropanes as Novel Probes for the Dopamine Transporter.

A. Newman, M. Zou, T. Kopajtic, 2002 .

CoMFA study of novel phenyl ring-substituted 3alpha-(diphenylmethoxy)tropane analogues at the dopamine transporter.

R. H. Kline, A. Newman, S. Izenwasser, 1999, Journal of medicinal chemistry.

Behavioral and Neurochemical Effects of the Dopamine Transporter Ligand 4-Chlorobenztropine Alone and in Combination with Cocaine In Vivo 1

A. Newman, J. Katz, S. Berger, 1999 .

Combinations of Cocaine with Other Dopamine Uptake Inhibitors: Assessment of Additivity

R. Tallarida, A. Newman, G. Tanda, 2009, Journal of Pharmacology and Experimental Therapeutics.

Population pharmacokinetics, brain distribution, and pharmacodynamics of 2nd generation dopamine transporter selective benztropine analogs developed as potential substitute therapeutics for treatment of cocaine abuse.

A. Newman, N. Eddington, Ahmed A. Othman, 2008, Journal of pharmaceutical sciences.

Dopamine D3 and D2 Receptor Mechanisms in the Abuse-Related Behavioral Effects of Cocaine: Studies with Preferential Antagonists in Squirrel Monkeys

R. Spealman, A. Newman, C. Achat-Mendes, 2010, Journal of Pharmacology and Experimental Therapeutics.

Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents.

Ji-Kyung Choi, Robert R Luedtke, Peter Grundt, 2007, Journal of medicinal chemistry.

The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion

Ming Xu, Amy Hauck Newman, J. Welge, 2007, Pharmacology Biochemistry and Behavior.

N-(4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl)arylcarboxamides as novel dopamine D(3) receptor antagonists.

A. Newman, R. Luedtke, Jianjing Cao, 2003, Bioorganic & medicinal chemistry letters.

The discriminative stimulus effects of dopamine D2- and D3-preferring agonists in rats

Mikhail N. Koffarnus, A. Newman, S. Husbands, 2009, Psychopharmacology.

Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia.

S. Franchini, A. Cilia, A. Newman, 2019, ACS chemical neuroscience.

Design and Synthesis of Fluorescent Methylphenidate Analogues for a FRET‐Based Assay of Synapsin III Binding

A. Newman, A. Casiraghi, E. Valoti, 2020, ChemMedChem.

N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity.

Robert R Luedtke, Amy Hauck Newman, D. Sibley, 2011, Journal of medicinal chemistry.

The stereotypy-inducing effects of N-substituted benztropine analogs alone and in combination with cocaine do not account for their blockade of cocaine self-administration

A. Newman, J. Katz, T. Hiranita, 2013, Psychopharmacology.

N-Substituted Benztropine Analogs: Selective Dopamine Transporter Ligands with a Fast Onset of Action and Minimal Cocaine-Like Behavioral Effects

A. Newman, T. Kopajtic, J. Katz, 2011, Journal of Pharmacology and Experimental Therapeutics.

Pharmacodynamic Assessment of the Benztropine Analogues AHN-1055 and AHN-2005 Using Intracerebral Microdialysis to Evaluate Brain Dopamine Levels and Pharmacokinetic/Pharmacodynamic Modeling

A. Newman, J. Katz, Jianjing Cao, 2005, Pharmaceutical Research.

Identification of a Dopamine Transporter Ligand That Blocks the Stimulant Effects of Cocaine

Mikhail N. Koffarnus, A. Newman, T. Kopajtic, 2005, The Journal of Neuroscience.

Novel benztropine [3a-(diphenylmethoxy)tropane] analogs as probes for the dopamine transporter.

A. Newman, G. Agoston, 1998, Current medicinal chemistry.

Feeding condition and the relative contribution of different dopamine receptor subtypes to the discriminative stimulus effects of cocaine in rats

A. Newman, C. France, M. Baladi, 2014, Psychopharmacology.

High-performance fast affinity chromatographic purification of anti-benzodiazepine antibodies.

P. Skolnick, A. Newman, K. Rice, 1986, Journal of Chromatography A.

Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists.

J. Deschamps, A. Newman, P. Conn, 2009, Journal of medicinal chemistry.

Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R).

D. Sibley, J. R. Lane, Lei Shi, 2017, Journal of medicinal chemistry.

Are There Prevalent Sex Differences in Psychostimulant Use Disorder? A Focus on the Potential Therapeutic Efficacy of Atypical Dopamine Uptake Inhibitors

A. Newman, G. Tanda, Melinda Hersey, 2023, Molecules.

Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics.

Antonina L. Nazarova, V. Katritch, J. R. Lane, 2023, Journal of medicinal chemistry.

Evidence for a stereoselective mechanism for bitopic activity by extended-length antagonists of the D3 dopamine receptor.

D. Sibley, J. R. Lane, Lei Shi, 2020, ACS chemical neuroscience.

Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation.

A. Newman, P. Grundt, T. Kopajtic, 2004, Journal of medicinal chemistry.

Novel anticonvulsant analogs of dextromethorphan: improved efficacy, potency, duration and side-effect profile.

F. Tortella, A. Newman, J. Witkin, 1994, The Journal of pharmacology and experimental therapeutics.

Interactions of calmodulin kinase II with the dopamine transporter facilitate cocaine-induced enhancement of evoked dopamine release

M. Michaelides, H. Sitte, A. Newman, 2023, Translational psychiatry.

Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans

Z. Xi, A. Newman, Thomas M. Keck, 2013, Psychopharmacology.

Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonists

Noel M. Paul, D. Sibley, A. Newman, 2015, European Neuropsychopharmacology.

Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor

Lei Shi, A. Newman, Alessandro Bonifazi, 2021, Biomolecules.

Neurochemical and behavioral comparisons of contingent and non-contingent methamphetamine exposure following binge or yoked long-access self-administration paradigms

H. Praag, J. Cadet, Z. Xi, 2020, Psychopharmacology.

[3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland

J. Reig, P. Skolnick, A. Newman, 1989, FEBS letters.

Probes for narcotic receptor mediated phenomena. 18. Epimeric 6 alpha- and 6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluation, and radiochemistry of [125I]-6 beta-iodo-

K. Berman, C. George, M. Iadarola, 1992, Journal of medicinal chemistry.

Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands.

J. Gutkind, A. Newman, T. Su, 1994, Journal of medicinal chemistry.

Scaffold Hybridization Strategy Leads to the Discovery of Dopamine D3 Receptor-Selective or Multitarget Bitopic Ligands Potentially Useful for Central Nervous System Disorders

G. Vistoli, A. Newman, Alessandro Bonifazi, 2021, ACS chemical neuroscience.

(+/-)-(N-alkylamino)benzazepine analogs: novel dopamine D1 receptor antagonists.

A. Newman, J. Witkin, S. Izenwasser, 1995, Journal of medicinal chemistry.

Aprophit: an irreversible antagonist for muscarinic receptors.

P. Chiang, A. Newman, H. Leader, 1990, Biochemical Pharmacology.

Muscarinic receptor subtype specificity of (N,N-dialkylamino)alkyl 2-cyclohexyl-2-phenylpropionates: cylexphenes (cyclohexyl-substituted aprophen analogues).

P. Chiang, R. K. Gordon, A. Newman, 1992, Journal of medicinal chemistry.

Novel irreversible ligands specific for "peripheral" type benzodiazepine receptors: (+/-)-, (+)-, and (-)-1-(2-chlorophenyl)-N-(1-methylpropyl)-N- (2-isothiocyanatoethyl)-3-isoquinolinecarboxamide and 1-(2-isothiocyanatoethyl)-7-chloro-1,3-dihydro-5-(4-chlorophenyl )-2H-1,4-benzodiazepin-2-one.

P. Skolnick, A. Newman, K. Rice, 1987, Journal of medicinal chemistry.

Dynorphin A-(1-17) induces alterations in free fatty acids, excitatory amino acids, and motor function through an opiate-receptor-mediated mechanism

A. Faden, A. Newman, A. Faden, 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Sigma receptors negatively modulate agonist-stimulated phosphoinositide metabolism in rat brain.

W. Bowen, A. Newman, K. Rice, 1988, European journal of pharmacology.

Relations between stimulation of mesolimbic dopamine and place conditioning in rats produced by cocaine or drugs that are tolerant to dopamine transporter conformational change

A. Newman, G. Tanda, M. Zou, 2013, Psychopharmacology.

Effects of ( R)-Modafinil and Modafinil Analogues on Dopamine Dynamics Assessed by Voltammetry and Microdialysis in the Mouse Nucleus Accumbens Shell.

A. Newman, G. Tanda, Jianjing Cao, 2019, ACS chemical neuroscience.

Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation.

A. Newman, M. Zou, T. Kopajtic, 2006, Journal of medicinal chemistry.

A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus

S. Ferré, A. Newman, Alessandro Bonifazi, 2016, ChemMedChem.

Novel 1-phenylcycloalkanecarboxylic acid derivatives as potential anticonvulsant agents.

F. Tortella, A. Newman, S. Calderon, 1991, Journal of medicinal chemistry.

A Medicinal Chemist's Journey at the National Institutes of Health One Molecule at a Time.

A. Newman, 2020, ACS Medicinal Chemistry Letters.

Chiral Cyclic Aliphatic Linkers as Building Blocks for Selective Dopamine D2 or D3 Receptor Agonists.

V. Katritch, A. Newman, Alessandro Bonifazi, 2021, Journal of medicinal chemistry.

High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice

Z. Xi, J. Javitch, A. Newman, 2015, Journal of medicinal chemistry.

Beyond small-molecule SAR: Using the dopamine D3 receptor crystal structure to guide drug design

Z. Xi, A. Newman, Guo-hua Bi, 2018 .

Presence of peripheral benzodiazepine binding sites on primary rat skeletal fibroblasts.

A. Newman, B. Weissman, H. F. Elson, 1990, European journal of pharmacology.

Disruptive mutations in the serotonin transporter associate serotonin dysfunction with treatment-resistant affective disorder

T. Werge, R. Blakely, H. Rasmussen, 2023, medRxiv.

A role for dopamine D1-like receptors in acute food deprivation-induced reinstatement of heroin seeking in rats.

A. Newman, U. Shalev, S. Tobin, 2009, The international journal of neuropsychopharmacology.

Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach

Henry J. Duff, Sergei Yu Noskov, Lei Shi, 2021, J. Chem. Inf. Model..

The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity

N. Volkow, M. Michaelides, P. Thanos, 2008, Pharmacology Biochemistry and Behavior.

Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder

A. Newman, Alessandro Bonifazi, S. Hemby, 2023, Journal of medicinal chemistry.

Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats

L. Dwoskin, P. Crooks, M. Bardo, 2018, Psychopharmacology.

Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile.

A. Newman, C. Loland, R. Rais, 2023, Journal of medicinal chemistry.

Dopamine D3 and D2 Receptor Mechanisms in the Abuse-Related Behavioral Effects of Cocaine: Studies with Preferential Antagonists in Squirrel Monkeys

R. Spealman, A. Newman, P. Grundt, 2010, Journal of Pharmacology and Experimental Therapeutics.

Relationship of the crystal structure of γ-N,N-dimethylaminopropyl 2,2-diphenylpropionate hydrochloride to antimuscarinic activity

I. Karle, P. Chiang, J. Karle, 1992 .

The stereotypy-inducing effects of N-substituted benztropine analogs alone and in combination with cocaine do not account for their blockade of cocaine self-administration

A. Newman, J. Katz, T. Hiranita, 2012, Psychopharmacology.

Dopamine D2 receptor activation increases vesicular dopamine uptake and redistributes vesicular monoamine transporter-2 protein.

A. Newman, G. Hanson, A. Fleckenstein, 2004, European journal of pharmacology.

Current Perspectives on Selective Dopamine D3 Receptor Antagonists/Partial Agonists as Pharmacotherapeutics for Opioid and Psychostimulant Use Disorders.

Z. Xi, A. Newman, C. Heidbreder, 2022, Current topics in behavioral neurosciences.

2-Isoxazol-3-Phenyltropane Derivatives of Cocaine: Molecular and Atypical System Effects at the Dopamine Transporter

C. Lupica, A. Newman, P. Soto, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66.

A. Newman, Alessandro Bonifazi, Thomas M. Keck, 2014, ACS medicinal chemistry letters.