E. Liepinsh

发表

Protein hydration in aqueous solution.

K Wüthrich, G Otting, K. Wüthrich, 1992, Faraday discussions.

Organic solvents identify specific ligand binding sites on protein surfaces

G. Otting, E. Liepinsh, 1997, Nature Biotechnology.

Metabolomic studies of experimental diabetic urine samples by 1H NMR spectroscopy and LC/MS method

A. Jankevics, E. Liepinsh, E. Liepinsh, 2009 .

Saposin fold revealed by the NMR structure of NK-lysin

Gottfried Otting, Edvards Liepinsh, J. Ruysschaert, 1997, Nature Structural Biology.

Lipid membrane binding of NK‐lysin

E. Goormaghtigh, J. Ruysschaert, G. Otting, 1998, FEBS letters.

Solution structure and dynamics of PEC-60, a protein of the Kazal type inhibitor family, determined by nuclear magnetic resonance spectroscopy.

G Otting, V. Mutt, K. Berndt, 1994, Journal of molecular biology.

Spectral and Quantum-Chemical Study of Nonequivalence of Methylene Protons in 1,4-Dihydropyridine Derivatives*

E. Liepinsh, B. Vīgante, A. Plotniece, 2014, Chemistry of Heterocyclic Compounds.

Intramolecular C-H···O Hydrogen Bonding in 1,4-Dihydropyridine Derivatives

E. Liepinsh, B. Vīgante, A. Plotniece, 2011, Molecules.

Protein hydration in aqueous solution.

K Wüthrich, G Otting, K. Wüthrich, 1991, Science.

N-alkylated dipeptide amides and related structures as imitations of the melanocortins’ active core

M. Lapinsh, F. Mutulis, E. Liepinsh, 2005, Peptides.

Crystal and Solution Structures of the Helicase-binding Domain of Escherichia coli Primase*

Guido Pintacuda, Gottfried Otting, Edvards Liepinsh, 2005, Journal of Biological Chemistry.

1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect

E. Liepinsh, G. Duburs, P. Arsenyan, 2015, Toxicology reports.

Experimental and Theoretical Studies of Bromination of Diethyl 2,4,6‐Trimethyl‐1,4‐dihydropyridine‐3,5‐dicarboxylate

E. Liepinsh, B. Vīgante, A. Sobolev, 2014 .

Fused Selenazolinium Salt Derivatives with a Se–N+ Bond: Preparation and Properties

E. Liepinsh, P. Arsenyan, S. Belyakov, 2015 .

NMR structure of the WIF domain of the human Wnt-inhibitory factor-1.

G. Otting, E. Liepinsh, L. Patthy, 2006, Journal of molecular biology.

Water-protein NOEs: Optimized scheme for selective water excitation

G. Otting, E. Liepinsh, 1999, Journal of biomolecular NMR.

Selective excitation of intense solvent signals in the presence of radiation damping

G. Otting, E. Liepinsh, 1995, Journal of biomolecular NMR.

Isolation and structure of a new galactolipid from oat seeds

M. Hamberg, G. Otting, E. Liepinsh, 1998, Lipids.

NMR observation of individual molecules of hydration water bound to DNA duplexes: direct evidence for a spine of hydration water present in aqueous solution.

K. Wüthrich, G. Otting, E. Liepinsh, 1992, Nucleic Acids Research.

Reaction of diaziridine-3,3-dicarboxylic acid dihydrazide with acetone

E. Liepinsh, S. Belyakov, P. Trapencieris, 2009 .

Protein Hydration Viewed by High‐Resolution NMR Spectroscopy: Implications for Magnetic Resonance Image Contrast

G. Otting, E. Liepinsh, 1995 .

Development of N6-methyl-2-(1,2,3-triazol-1-yl)-2′-deoxyadenosine as a novel fluorophore and its application in nucleotide synthesis

E. Liepinsh, M. Turks, D. Stepanovs, 2016 .

Intramolecular hydrogen bonds in 1,4-dihydropyridine derivatives

E. Liepinsh, G. Duburs, R. Muhamadejev, 2018, Royal Society Open Science.

Random coil conformation of a Gly/Ala‐rich insert in IκBα excludes structural stabilization as the mechanism for protection against proteasomal degradation

G. Otting, M. Masucci, E. Liepinsh, 1998 .

Synthesis and cytotoxic properties of 7α-chloro-3-methyl-1,1-dioxoceph-3-ems, substituted with amide or keto group at position 4

E. Liepinsh, E. Lukevics,, M. Petrova, 2007 .

Synthesis and anticancer properties of 7α-chloro-3-methyl-1,1-dioxoceph-3-em-4-carboxylic acid esters

E. Liepinsh, E. Lukevics,, M. Petrova, 2007 .

Synthesis and properties of hydrogenated 2-alkylthio-5-oxo-3-cyanoindeno [1,2-b]-pyridines

E. Liepinsh, G. Dubur, A. Krauze, 1990, Chemistry of Heterocyclic Compounds.

Synthesis and stereochemical structure of derivatives of 2-substituted 3-cyclohexenylamidoquinazolin-4-ones obtained from N′-cyclohexenecarbonyl-substituted hydrazides of 2-aminobenzoic acid and certain orthoesters

E. Liepinsh, M. Petrova, D. Zicāne, 2008 .

Asymmetric Synthesis of 1,3-Diamines. II: Diastereoselective reduction of atropisomeric N-tert-butanesulfinylketimines.

E. Liepinsh, S. Belyakov, E. Suna, 2011, The Journal of organic chemistry.

Synthesis and Stereochemical Structure of Derivatives of 2‐Substituted 3‐Cyclohexenylamidoquinazolin‐4‐ones Obtained from N′‐Cyclohexenecarbonyl‐Substituted Hydrazides of 2‐Aminobenzoic Acid and Certain Orthoesters.

E. Liepinsh, M. Petrova, D. Zicāne, 2009 .

Asymmetric synthesis of 1,3-diamines by diastereoselective reduction of enantiopure N-tert-butanesulfinylketimines: unusual directing effects of the ortho-substituent.

E. Liepinsh, S. Belyakov, E. Suna, 2010, The Journal of organic chemistry.

Unexpected reaction on bromination of 3,4-dihydropyridin-2(1H)-ones with N-bromosuccinimide

E. Liepinsh, G. Duburs, A. Krauze, 2007 .

Oligomerization of Indole Derivatives with Incorporation of Thiols

Sviatlana Yahorava, F. Mutulis, E. Liepinsh, 2008, Molecules.

Synthesis of Novel Unsymmetrically Substituted 1,4-Dihydroisonicotinic Acid and its Derivatives

S. Belyakov, E. Liepinsh, I. Goba, 2013, Chemistry of Heterocyclic Compounds.

Synthesis of 2-(4′-R-benzylidene)-4-aza-1,3-indanediones and investigation of isomerization around the exocyclic double bond

E. Liepinsh, V. Kampars, M. Petrova, 2008 .

Preparation and characterization of selenopheno[2,3-b]pyridine N-oxides

E. Liepinsh, P. Arsenyan, S. Belyakov, 2016 .

Cyclization of Diaryl(hetaryl)alkynes under Selenobromination Conditions: Regioselectivity and Mechanistic Studies

E. Liepinsh, P. Arsenyan, S. Belyakov, 2015 .

Separation of Selected Derivatives of Hoszczawa-Silanates, Taking Advantage of π–π Interactions

E. Liepinsh, M. Michel, N. Erchak, 2008 .

High Performance Liquid Chromatography of Benzyl Derivatives of ES‐Silanates

E. Liepinsh, R. Gadzała-Kopciuch, M. Michel, 2008 .

Separation of Azepinio‐Methyl Derivatives of ES‐Silanates by the Use of Aryl Stationary Phases in HPLC

E. Liepinsh, N. Erchak, M. Kluska, 2008 .

Targeting carnitine biosynthesis: discovery of new inhibitors against γ-butyrobetaine hydroxylase.

A. Kazaks, K. Tārs, E. Liepinsh, 2014, Journal of medicinal chemistry.

Proton exchange with internal water molecules in the protein BPTI in aqueous solution

G. Otting, E. Liepinsh, K. Wuethrich, 1991 .

Hydration of proteins. A comparison of experimental residence times of water molecules solvating the bovine pancreatic trypsin inhibitor with theoretical model calculations.

K Wüthrich, W F van Gunsteren, G Otting, 1993, Journal of molecular biology.

NMR and Quantum-Chemical Studies of Electrostatically Stabilized 1-(N,N-Substituted-aminiomethyl)spirobi[3-oxo(2,5-dioxa-1-silacyclopentan)]ates (ES-Silanates)

E. Liepinsh, S. Belyakov, E. Olszewska, 2014 .

15N NMR of 1,4‐dihydropyridine derivatives

E. Liepinsh, I. Goba, 2013, Magnetic resonance in chemistry : MRC.

Synthesis, spectroscopic and conformational analysis of 1,4-dihydroisonicotinic acid derivatives

E. Liepinsh, S. Belyakov, B. Turovska, 2014 .

Protein Hydration Viewed by High-Resolution NMR Spectroscopy: Implications for Magnetic Resonance Image Contrast

G. Otting, E. Liepinsh, 1995 .

Libiguins A and B: Novel Phragmalin Limonoids Isolated from Neobeguea mahafalensis Causing Profound Enhancement of Sexual Activity

Sviatlana Yahorava, F. Mutulis, E. Liepinsh, 2014, Planta Medica.

A Novel Insulin-releasing Substance, Phanoside, from the Plant Gynostemma pentaphyllum*

C. Östenson, H. Jörnvall, E. Liepinsh, 2004, Journal of Biological Chemistry.

Semisynthesis of libiguin A and its analogues by trans-lactonization of phragmalin.

Sviatlana Yahorava, Aigars Jirgensons, Liene Grigorjeva, 2014, The Journal of organic chemistry.

New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of "THIQ".

Sviatlana Yahorava, F. Mutulis, K. Tārs, 2004, Journal of medicinal chemistry.

Electrochemical oxidation of 4-monoalkyl-substituted 1,4-dihydropyridines

E. Liepinsh, S. Belyakov, S. Grinberga, 2008 .

Electrochemical synthesis of 1,2,3,4,4,5,6-substituted 1,4-dihydropyridines

E. Liepinsh, S. Belyakov, J. Stradiņš, 2007 .

Natural-Antioxidant-Inspired Benzo[b]selenophenes: Synthesis, Redox Properties, and Antiproliferative Activity.

E. Liepinsh, P. Arsenyan, M. Petrova, 2016, Chemistry, an Asian journal.

Heteronuclear correlation experiments for the determination of one-bond coupling constants

G. Otting, E. Liepinsh, M. Sunnerhagen, 1998, Journal of biomolecular NMR.

NMR structure of the death domain of the p 75 neurotrophin receptor affinity binding sites ( Hempstead et al . , 1991 ; Mahadeo

G. Otting, E. Liepinsh, L. Ilag, 1997 .

Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism

E. Liepinsh, E. Liepinsh, M. Dambrova, 2009, Journal of enzyme inhibition and medicinal chemistry.

NMR structure of the death domain of the p75 neurotrophin receptor

G. Otting, E. Liepinsh, L. Ilag, 1997, The EMBO journal.

Role of charged and hydrophobic residues in the oligomerization of the PYRIN domain of ASC.

G. Otting, E. Liepinsh, J. Sagara, 2005, Biochemistry.

The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition.

E. Dahl, E. Staub, G. Otting, 2003, Journal of molecular biology.

NMR spectroscopy of hydroxyl protons in aqueous solutions of peptides and proteins

K. Wüthrich, G. Otting, E. Liepinsh, 1992, Journal of biomolecular NMR.

NMR structure of the LCCL domain and implications for DFNA9 deafness disorder

J. Weigelt, G. Otting, E. Liepinsh, 2001, The EMBO journal.

Proton exchange rates from amino acid side chains— implications for image contrast

Gottfried Otting, Edvards Liepinsh, G. Otting, 1996, Magnetic resonance in medicine.

Selection of a peptide ligand to the p75 neurotrophin receptor death domain and determination of its binding sites by NMR.

G. Otting, E. Liepinsh, L. Ilag, 1999, Biochemical and biophysical research communications.

Protein hydration in aqueous solution.

K. Wüthrich, G. Otting, E. Liepinsh, 1991, Science.

Solution structure of a hydrophobic analogue of the winter flounder antifreeze protein.

J. Mackay, G. Otting, E. Liepinsh, 2002, European journal of biochemistry.

Stabilization of native protein fold by intein-mediated covalent cyclization.

Phil Attard, Gottfried Otting, N. K. Williams, 2005, Journal of molecular biology.

A novel zinc-binding fold in the helicase interaction domain of the Bacillus subtilis DnaI helicase loader

N. Dixon, G. Otting, E. Liepinsh, 2009, Nucleic acids research.

Specificity of Urea Binding to Proteins

Gottfried Otting, Edvards Liepinsh, G. Otting, 1994 .

NMR structure of Citrobacter freundii AmpD, comparison with bacteriophage T7 lysozyme and homology with PGRP domains.

B. Joris, G. Otting, E. Liepinsh, 2003, Journal of molecular biology.

Pathway of chymotrypsin evolution suggested by the structure of the FMN-binding protein from Desulfovibrio vulgaris (Miyazaki F)

G. Otting, E. Liepinsh, M. Kitamura, 1997, Nature Structural Biology.

Common ancestor of serine proteases and flavin-binding domains

G. Otting, E. Liepinsh, M. Kitamura, 1998, Nature Structural Biology.

Validation of the CHARMM27 force field for nucleic acids using 2D nuclear overhauser effect spectroscopy

E. Liepinsh, Kirill Zinovjev, 2013 .

NMR identification of hydrophobic cavities with ow water occupancies in protein structures using small gas molecules

G. Otting, B. Halle, E. Liepinsh, 1997, Nature Structural Biology.

Secondary structure assignment of mouse SOCS3 by NMR defines the domain boundaries and identifies an unstructured insertion in the SH2 domain

R. Norton, L. Fabri, S. Yao, 2005, The FEBS journal.

Dynamics of protein and peptide hydration.

G. Otting, B. Halle, E. Liepinsh, 2004, Journal of the American Chemical Society.

In Vivo Protein Cyclization Promoted by a Circularly Permuted Synechocystis sp. PCC6803 DnaB Mini-intein*

Nicholas E. Dixon, Paul M. G. Curmi, Gottfried Otting, 2002, The Journal of Biological Chemistry.

Lunasin is a redox sensitive intrinsically disordered peptide with two transiently populated α-helical regions

E. Liepinsh, R. Muceniece, R. Aleksis, 2016, Peptides.

Disulfide bond isomerization in BPTI and BPTI(G36S): an NMR study of correlated mobility in proteins.

K. Wüthrich, G. Otting, E. Liepinsh, 1993, Biochemistry.

The mechanism of the anaerobic Escherichia coli ribonucleotide reductase investigated with nuclear magnetic resonance spectroscopy.

G. Otting, M. Fontecave, E. Liepinsh, 1995, Biochemical and biophysical research communications.

Minor groove hydration of DNA in aqueous solution: sequence-dependent next neighbor effect of the hydration lifetimes in d(TTAA)2 segments measured by NMR spectroscopy.

E. Liepinsh, W. Leupin, F. Otting, 1996, Nucleic acids research.

Study of interactions of mononucleotides with 1,4-dihydropyridine vesicles using NMR and ITC techniques

E. Liepinsh, K. Pajuste, A. Plotniece, 2018 .

Structure and influence on stability and activity of the N‐terminal propeptide part of lung surfactant protein C

J. Thyberg, J. Johansson, H. Jörnvall, 2005, The FEBS journal.

Edvards Liepinsh, MaÂ

J. Weigelt, G. Otting, E. Liepinsh, 2022 .

Benzo[b]thiophen-3(2H)-one 1,1-dioxide—a versatile reagent in the synthesis of spiroheterocycles

E. Liepinsh, A. Sobolev, A. Plotniece, 2008 .

Unusual cyclization of 1-thianaphthenone-3-dioxide-1,1 to a 1,5-diazabicyclo[3.3.1]nonane—a heterocyclic analogue of a Tröger's base

E. Liepinsh, B. Cekavicus, G. Duburs, 2001 .

Benzo[b]thiophen‐3(2H)‐one 1,1‐Dioxide — A Versatile Reagent in the Synthesis of Spiroheterocycles.

E. Liepinsh, A. Sobolev, A. Plotniece, 2009 .

Ring opening of benzo[a]pyrene in the germ-free rat is a novel pathway for formation of potentially genotoxic metabolites.

J. Gustafsson, G. Otting, J. Bergman, 2000, Biochemistry.

NMR Structure of the Netrin-like Domain (NTR) of Human Type I Procollagen C-Proteinase Enhancer Defines Structural Consensus of NTR Domains and Assesses Potential Proteinase Inhibitory Activity and Ligand Binding*

G. Otting, E. Liepinsh, L. Patthy, 2003, Journal of Biological Chemistry.

Thioredoxin fold as homodimerization module in the putative chaperone ERp29: NMR structures of the domains and experimental model of the 51 kDa dimer.

M. Ingelman-Sundberg, G. Otting, E. Liepinsh, 2001, Structure.

Hydration of DNA in aqueous solution: NMR evidence for a kinetic destabilization of the minor groove hydration of d-(TTAA)2 versus d-(AATT)2 segments.

G. Otting, E. Liepinsh, W. Leupin, 1994, Nucleic Acids Research.

Protein hydration studied with homonuclear 3D1H NMR experiments

K Wüthrich, G Otting, K. Wüthrich, 1991, Journal of biomolecular NMR.

Solution structure of the R3H domain from human Smubp-2.

Gottfried Otting, Edvards Liepinsh, G. Otting, 2003, Journal of molecular biology.

Unordered structure of proinsulin C-peptide in aqueous solution and in the presence of lipid vesicles

J. Johansson, H. Jörnvall, E. Liepinsh, 2000, Cellular and Molecular Life Sciences CMLS.

Polypeptide hydration in mixed solvents at low temperatures

Gottfried Otting, Edvards Liepinsh, G. Otting, 1992 .

Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.

E. Liepinsh, S. Belyakov, R. Vilskersts, 2013, Bioorganic & medicinal chemistry.

Structural basis for 5'-end-specific recognition of single-stranded DNA by the R3H domain from human Sμbp-2.

Kristaps Jaudzems, Xinying Jia, Hiromasa Yagi, 2012, Journal of molecular biology.

Solution Structure of the R 3 H Domain from Human S m bp-2

G. Otting, E. Liepinsh, A. Leonchiks, 2003 .

Letter to the Editor: NMR structure of human coactosin-like protein

G. Otting, E. Liepinsh, B. Samuelsson, 2004 .

Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein

G. Otting, E. Liepinsh, L. Patthy, 2006, Journal of biomolecular NMR.

Folding into a β-Hairpin Can Prevent Amyloid Fibril Formation†

B. Persson, L. Tjernberg, Waltteri Hosia, 2004 .

Folding into a beta-hairpin can prevent amyloid fibril formation.

B. Persson, L. Tjernberg, Waltteri Hosia, 2004, Biochemistry.

NMR structure of the WIF domain of the human Wnt-inhibitory factor-1.

G. Otting, E. Liepinsh, L. Patthy, 2006, Journal of Molecular Biology.

Contributions from hydration of carboxylate groups to the spectrum of water-polypeptide proton-proton Overhauser effects in aqueous solution

K. Wüthrich, G. Otting, E. Liepinsh, 1993, Journal of biomolecular NMR.