Wei Zhang

发表

Moyamoya Disease-Associated RNF213 Alleles Encode Dominant Negative Alleles That Globally Impair Ubiquitylation

B. Neel, S. Sidhu, Abhishek Bhardwaj, 2020, bioRxiv.

piRNA profiling during specific stages of mouse spermatogenesis.

Wei Zhang, Chunsheng Han, H. Gan, 2011, RNA.

A Two-Sided Matching Model for Task Distribution in Ridesharing: A Sustainable Operations Perspective

Wei Zhang, Cejun Cao, Qin Yang, 2019, Sustainability.

The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins.

Wei Zhang, J Günter Grossmann, Ernest D Laue, 2006, Journal of molecular biology.

Biochemical and structural studies of the interaction of Cdc37 with Hsp90.

Wei Zhang, J Günter Grossmann, Ernest D Laue, 2004, Journal of molecular biology.

Emerging drug development technologies targeting ubiquitination for cancer therapeutics

S. Sidhu, Wei Zhang, Gianluca Veggiani, 2019, Pharmacology & Therapeutics.

The Stomatin-Like Protein SLP-1 and Cdk2 Interact with the F-Box Protein Fbw7-γ

D. Koepp, Wei Zhang, E. M. MacDonald, 2012, PloS one.

DNA damage signalling targets the kinetochore to promote chromatin mobility

D. Durocher, L. Pelletier, J. Strecker, 2016, Nature Cell Biology.

A Meier-Gorlin syndrome mutation impairs the ORC1-nucleosome association.

O. Gozani, Jikui Song, Wei Zhang, 2015, ACS chemical biology.

The PHD and Chromo Domains Regulate the ATPase Activity of the Human Chromatin Remodeler CHD4

D. Svergun, T. Kouzarides, T. Owen-Hughes, 2012, Journal of molecular biology.

ELL targets c-Myc for proteasomal degradation and suppresses tumour growth

Wei Zhang, Xing Liu, Dawei Zhang, 2016, Nature Communications.

In Silico Discovery of Potential VEGFR-2 Inhibitors from Natural Derivatives for Anti-Angiogenesis Therapy

Wei Zhang, Nan Zhou, Chuanfang Wu, 2014, International journal of molecular sciences.

p53 directly suppresses BNIP3 expression to protect against hypoxia‐induced cell death

Wei Zhang, Xing Liu, W. Xiao, 2011, The EMBO journal.

The Pentameric Nucleoplasmin Fold Is Present in Drosophila FKBP39 and a Large Number of Chromatin-Related Proteins

V. T. Forsyth, E. Laue, D. Glover, 2015, Journal of molecular biology.

The Role of Polo-like Kinase 1 in the Inhibition of Centrosome Separation after Ionizing Radiation*

R. Muschel, Wei Zhang, Lynda Fletcher, 2005, Journal of Biological Chemistry.

Genomic expression analysis by single‐cell mRNA differential display of quiescent CD8 T cells from tumour‐infiltrating lymphocytes obtained from in vivo liver tumours

Wei Zhang, Hongliang Hu, Biaoru Li, 2009, Immunology.

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

J. Moffat, J. Harper, K. Brown, 2016, Molecular cell.

Resource System-Wide Modulation o f HECT E 3 Ligases with Selective Ubiquitin Variant Probes Graphical Abstract Highlights

J. Moffat, J. Harper, K. Brown, 2016 .

Targeted Degradation of 53BP1 Using Ubiquitin Variant Induced Proximity

Wei Zhang, J. Fux, Bayonle Aminu, 2022, Biomolecules.

Drug development: Allosteric inhibitors hit USP7 hard.

S. Sidhu, Wei Zhang, 2018, Nature chemical biology.

Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10.

J. Moffat, Taras Makhnevych, S. Sidhu, 2017, Journal of molecular biology.

PTP1B regulates non-mitochondrial oxygen consumption via RNF213 to promote tumour survival during hypoxia

S. Gygi, J. Dennis, T. Kislinger, 2016 .

Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors.

G. Mills, J. Ajani, Z. Ju, 2020, The Journal of clinical investigation.

The von hippel-lindau protein suppresses androgen receptor activity.

Wei Zhang, Xing Liu, W. Xiao, 2014, Molecular endocrinology.

pVHL acts as a downstream target of E2F1 to suppress E2F1 activity.

Wei Zhang, Xing Liu, W. Xiao, 2014, The Biochemical journal.

The contribution of CMP kinase to the efficiency of DNA repair

Wei Zhang, Z. Chang, Ning Tsao, 2015, Cell cycle.

De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks.

D. Durocher, Wei Zhang, 2010, Genes & development.

Regulation of Sexual Dimorphism: Mutational and Chemogenetic Analysis of the Doublesex DM Domain

M. Weiss, Wei Zhang, Lingyang Zhu, 2006, Molecular and Cellular Biology.

ELL Inhibits E2F1 Transcriptional Activity by Enhancing E2F1 Deacetylation via Recruitment of Histone Deacetylase 1

Wei Zhang, Xing Liu, W. Xiao, 2013, Molecular and Cellular Biology.

Recruitment of Histone Deacetylase 1 by Enhancing E 2 F 1 Deacetylation via ELL Inhibits E 2 F 1 Transcriptional Activity

Wei Zhang, Xing Liu, W. Xiao, 2014 .

NME3 Regulates Mitochondria to Reduce ROS-Mediated Genome Instability

Wei Zhang, Z. Chang, Ning Tsao, 2020, International journal of molecular sciences.

Rapid isolation of peptidic inhibitors of the solute carrier family transporters OATP1B1 and OATP1B3 by cell-based phage display selections.

S. Sidhu, Y. Arita, Wei Zhang, 2016, Biochemical and biophysical research communications.

In vitro selection of DNA-cleaving deoxyribozyme with site-specific thymidine excision activity

Wei Zhang, Yongyun Zhao, Zhuo Tang, 2014, Nucleic acids research.

Targeting the Ubiquitin-Proteasome System for Cancer Therapeutics by Small-Molecule Inhibitors

Wei Zhang, Gabriel LaPlante, 2021, Cancers.

Folding mechanism of an ankyrin repeat protein: scaffold and active site formation of human CDK inhibitor p19(INK4d).

E. Laue, F. Schmid, C. Löw, 2007, Journal of molecular biology.

DNA Damage Response Is Suppressed by the High Cyclin-dependent Kinase 1 Activity in Mitotic Mammalian Cells*

G. Peng, Shiaw-Yih Lin, Pumin Zhang, 2011, The Journal of Biological Chemistry.

Analysis of Telomere Healing of DNA Double-strand Breaks

Wei Zhang, 2012 .

Structural Basis for the Recognition of Histone H4 by the Histone-Chaperone RbAp46

X. Pei, B. Luisi, E. Laue, 2008, Structure.

Targeting the Ubiquitin Signaling Cascade in Tumor Microenvironment for Cancer Therapy

Wei Zhang, Bayonle Aminu, Olivia Roscow, 2021, International journal of molecular sciences.

CRISPR-Cas12a induced DNA double-strand breaks are repaired by locus-dependent and error-prone pathways in a fungal pathogen

Wei Zhang, B. Valent, D. Rowe, 2021, bioRxiv.

Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.

J. Peters, H. Stark, P. Dube, 2016, Molecular cell.

The Hect Domain E3 Ligase Tom1 and the F-box Protein Dia2 Control Cdc6 Degradation in G1 Phase*

D. Koepp, Wei Zhang, Dong-Hwan Kim, 2012, The Journal of Biological Chemistry.

Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL)*

Wei Zhang, Xing Liu, Xiaolian Cai, 2016, The Journal of Biological Chemistry.

Inhibition of the ATM / Chk 2 axis promotes cGAS / STING signaling in ARID 1 A-deficient tumors

G. Mills, J. Ajani, Z. Ju, 2020 .

Disruption of the mevalonate pathway induces dNTP depletion and DNA damage.

M. J. Hazen, D. Gómez-Coronado, M. A. Lasunción, 2015, Biochimica et biophysica acta.

Doublesex and the Regulation of Sexual Dimorphism in Drosophila melanogaster

M. Weiss, Wei Zhang, Yanwu Yang, 2008, Journal of Biological Chemistry.

pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation

Juan Du, Wei Zhang, Xing Liu, 2015, The Journal of Immunology.

This information is current as Proteasomal Degradation Signaling by Targeting MAVS for pVHL Negatively Regulates Antiviral

Wei Zhang, Xing Liu, Dawei Zhang, 2015 .

Targeted modulation of E3 ligases using engineered ubiquitin variants

Wei Zhang, E. Mallette, Nicole A. Leblanc, 2020, The FEBS journal.

Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency

D. Durocher, F. Sicheri, Alexandre Orthwein, 2017, Nature Biotechnology.

Human nuclease/helicase DNA2 alleviates replication stress by promoting DNA end resection.

Ju-Seog Lee, G. Peng, I. Bedrosian, 2012, Cancer research.

E2F-1 Directly Regulates Thrombospondin 1 Expression

Wei Zhang, W. Xiao, Wei Ji, 2010, PloS one.

Computer-aided identification of potential TYK2 inhibitors from drug database

J. Bao, Wei Zhang, Chuanfang Wu, 2016 .

Development of inhibitors in the ubiquitination cascade

S. Sidhu, Wei Zhang, 2013, FEBS Letters.

The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination.

Grant W. Brown, M. Tyers, A. Gingras, 2010, Molecular cell.

Nessun Dorma, a novel centralspindlin partner, is required for cytokinesis in Drosophila spermatocytes

E. Laue, D. Glover, Wei Zhang, 2010, The Journal of cell biology.

Mining and characterization of ubiquitin E3 ligases expressed in the mouse testis

Wei Zhang, Chunsheng Han, H. Gan, 2012, BMC Genomics.

Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process

D. Durocher, J. Strecker, Wei Zhang, 2015, Nature Communications.

Fbw7 Isoform Interaction Contributes to Cyclin E Proteolysis

D. Koepp, Wei Zhang, 2006, Molecular Cancer Research.

Insight into the Architecture of the NuRD Complex

A. H. Smits, M. Vermeulen, X. Pei, 2014, The Journal of Biological Chemistry.

Molecular Analysis of Core Kinetochore Composition and Assembly in Drosophila melanogaster

E. Laue, K. Lilley, D. Glover, 2007, PloS one.

The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through Degradation of SAK/PLK4

E. Laue, D. Glover, M. Bettencourt-Dias, 2009, Current Biology.

Recruitment of Polo Kinase to the Spindle Midzone during Cytokinesis Requires the Feo/Klp3A Complex

E. Laue, K. Lilley, D. Glover, 2007, PloS one.

Cryo-EM ofMitotic Checkpo int Complex-Bound APC / C RevealsReciprocalandConformationalRegulationof Ubiquitin Ligation Graphical

J. Peters, H. Stark, P. Dube, 2016 .

Differential UBE2H-CTLH E2-E3 ubiquitylation modules regulate erythroid maturation

M. Mann, J. Nilvebrant, M. Weiss, 2022, bioRxiv.

Microscale thermophoresis for the assessment of nuclear protein-binding affinities.

E. Laue, S. Duhr, P. Baaske, 2014, Methods in molecular biology.

Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1

O. Fedorov, T. Owen-Hughes, E. Laue, 2012, Nature Structural &Molecular Biology.

Dimerization of Doublesex Is Mediated by a Cryptic Ubiquitin-associated Domain Fold

M. Weiss, Wei Zhang, J. Bayrer, 2005, Journal of Biological Chemistry.

Generating Intracellular Modulators of E3 Ligases and Deubiquitinases from Phage-Displayed Ubiquitin Variant Libraries.

S. Sidhu, Wei Zhang, 2018, Methods in molecular biology.

Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants

S. Sidhu, Wei Zhang, M. Kikkert, 2017, PLoS pathogens.

Isolation of protein complexes involved in mitosis and cytokinesis from Drosophila cultured cells.

E. Laue, D. Glover, Wei Zhang, 2009, Methods in molecular biology.

Interaction between Anillin and RacGAP50C connects the actomyosin contractile ring with spindle microtubules at the cell division site

Wei Zhang, Kathryn S Lilley, Ernest D Laue, 2008, Journal of Cell Science.

Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.

D. Durocher, C. Arrowsmith, F. Sicheri, 2008, Molecular cell.

Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery

G. Mills, Yiling Lu, G. Peng, 2018, Nature Communications.

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C

B. Kuhlman, M. Kirschner, J. Peters, 2016, Cell.

Dual RING E 3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC / C Graphical

B. Kuhlman, M. Kirschner, J. Peters, 2022 .

Conformational dynamics of the molecular chaperone Hsp90 in complexes with a co-chaperone and anticancer drugs.

Wei Zhang, Ernest D Laue, Sophie E Jackson, 2007, Journal of molecular biology.

The crystal structure of the BAR domain from human Bin1/amphiphysin II and its implications for molecular recognition.

Wei Zhang, Ernest D Laue, Juan Fernandez-Recio, 2006, Biochemistry.

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site

J. Peters, H. Stark, S. Sidhu, 2019, Proceedings of the National Academy of Sciences.

A Protein Engineering Approach for Uncovering Cryptic Ubiquitin-binding Sites: from a Ubiquitin-Variant Inhibitor of APC/C to K48 Chain Binding

J. Peters, H. Stark, S. Sidhu, 2019, bioRxiv.

Molecular and Cellular Pathobiology Human Nuclease / Helicase DNA 2 Alleviates Replication Stress by Promoting DNA End Resection

Ju-Seog Lee, G. Peng, I. Bedrosian, 2012 .

Zebrafish eaf1 suppresses foxo3b expression to modulate transcriptional activity of gata1 and spi1 in primitive hematopoiesis.

Wei Zhang, W. Xiao, Xi Feng, 2014, Developmental biology.

Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.

S. Gygi, L. Rubin, J. Harper, 2018, Molecular cell.

Recent developments in engineering protein-protein interactions using phage display.

Wei Zhang, Olivia Roscow, Chen Liang, 2021, Protein engineering, design & selection : PEDS.

A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants

Brian O. Smith, S. Sidhu, M. Nakasone, 2017, Molecular cell.

A General Strategy for Dis covery of Inhibitors and Activators of RING and U-box E 3 Ligases with Ubiquitin Variants Graphical Abstract Highlights

Brian O. Smith, S. Sidhu, M. Nakasone, 2017 .

Dynamics of PARKIN-Depe ndent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics Graphical

S. Gygi, L. Rubin, J. Harper, 2022 .

The C. elegans L1CAM homologue LAD-2 functions as a coreceptor in MAB-20/Sema2–mediated axon guidance

H. Hutter, D. Koepp, Wei Zhang, 2008, The Journal of cell biology.

Engineering cell signaling modulators from native protein-protein interactions.

S. Sidhu, Wei Zhang, M. Ben-David, 2017, Current opinion in structural biology.

MMD-associated RNF213 SNPs encode dominant-negative alleles that globally impair ubiquitylation

B. Neel, S. Sidhu, Abhishek Bhardwaj, 2022, Life Science Alliance.

The C. elegans L1CAM homologue LAD-2 functions as a coreceptor in MAB-20/Sema2–mediated axon guidance

H. Hutter, D. Koepp, Wei Zhang, 2008, The Journal of cell biology.

Identification and Characterization of Mutations in Ubiquitin Required for Non-covalent Dimer Formation

S. Sidhu, M. Gabrielsen, Wei Zhang, 2019, Structure.

Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery

G. Mills, Wei Zhang, Yiling Lu, 2018, Nature Communications.

A genetically encoded inhibitor of 53BP1 to stimulate homology-based gene editing

D. Durocher, F. Sicheri, Alexandre Orthwein, 2016, bioRxiv.

Molecular and Cellular Pathobiology Human Nuclease/helicase Dna2 Alleviates Replication Stress by Promoting Dna End Resection

Ju-Seog Lee, G. Peng, I. Bedrosian, 2022 .

Doublesex and the Regulation of Sexual Dimorphism in Drosophila melanogaster

M. Weiss, Wei Zhang, Yanwu Yang, 2008, Journal of Biological Chemistry.

Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process

D. Durocher, J. Strecker, Wei Zhang, 2015, Nature Communications.

Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.

D. Durocher, C. Arrowsmith, F. Sicheri, 2008, Molecular cell.

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site

H. Stark, S. Sidhu, B. Schulman, 2019, Proceedings of the National Academy of Sciences.

Dun1 counts on rad53 to be turned on.

D. Durocher, Wei Zhang, 2008, Molecular cell.

Section 4: Immunopharmacology

S. Sidhu, Wei Zhang, M. Kikkert, 2017, Acta Pharmacologica Sinica.