G. M. Di Guglielmo

发表

Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain.

J. Wrana, C. Le Roy, F. Sicheri, 2005, Molecular cell.

Decorin is a novel VEGFR-2-binding antagonist for the human extravillous trophoblast.

G. M. Di Guglielmo, G. Khan, P. Lala, 2011, Molecular endocrinology.

SMURF2 and SMAD7 induce SARA degradation via the proteasome.

G. M. Di Guglielmo, Sanghyun Lee, S. Wojtowicz, 2020, Cellular signalling.

The extracellular domain of the TGFbeta type II receptor regulates membrane raft partitioning.

M. O’Connor-McCourt, J. Wrana, V. Luga, 2009, The Biochemical journal.

Assessing methods to quantitatively validate TGFβ-dependent autophagy

G. M. Di Guglielmo, Charles B Trelford, Charles B. Trelford, 2020, Biology Open.

Autophagy regulates transforming growth factor β signaling and receptor trafficking.

G. M. Di Guglielmo, Charles B Trelford, 2022, Biochimica et biophysica acta. Molecular cell research.

Molecular mechanisms of mammalian autophagy.

G. M. Di Guglielmo, Charles B Trelford, Charles B. Trelford, 2021, The Biochemical journal.

Modulation of type II TGF-β receptor degradation by integrin-linked kinase.

G. M. Di Guglielmo, L. Dagnino, S. McLean, 2015, The Journal of investigative dermatology.

Prolonged proteasome inhibition antagonizes TGFβ1-dependent signalling by promoting the lysosomal-targeting of TGFβ receptors.

G. M. Di Guglielmo, Charles B Trelford, Charles B. Trelford, 2022, Cellular signalling.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

TGF beta (transforming growth factor beta) receptor type III directs clathrin-mediated endocytosis of TGF beta receptor types I and II.

G. M. Di Guglielmo, S. McLean, 2010, The Biochemical journal.

Transforming growth factor-β in tumour development

G. M. Di Guglielmo, L. Dagnino, Charles B Trelford, 2022, Frontiers in Molecular Biosciences.

Dynamics of Transforming Growth Factor Beta Signaling in Wound Healing and Scarring.

G. M. Di Guglielmo, A. Philip, S. McLean, 2013, Advances in wound care.

Regulation of Cytokine Receptors by Golgi N-Glycan Processing and Endocytosis

J. Dennis, I. Nabi, J. Wrana, 2004, Science.

Synthetic triterpenoids inhibit GSK3β activity and localization and affect focal adhesions and cell migration.

G. M. Di Guglielmo, M. Prado, Ciric To, 2017, Biochimica et biophysica acta. Molecular cell research.

aPKC alters the TGF&bgr; response in NSCLC cells through both Smad-dependent and Smad-independent pathways

G. M. Di Guglielmo, Eddie Chan, A. Gunaratne, 2015, Journal of Cell Science.

Regulation of TGFβ receptor trafficking and signaling by atypical protein kinase C.

G. M. Di Guglielmo, H. Benchabane, A. Gunaratne, 2012, Cellular signalling.

A G1 cell cycle arrest induced by ligands of the reovirus type 3 receptor is secondary to inactivation of p21ras and mitogen-activated protein kinase.

D. Rubin, M. Greene, G. M. Di Guglielmo, 1999, DNA and cell biology.

Compartmentalized signal transduction by receptor tyrosine kinases.

G. M. Di Guglielmo, B. Posner, J. Bergeron, 1995, Trends in cell biology.

Inhibition of Endosomal Insulin-like Growth Factor-I Processing by Cysteine Proteinase Inhibitors Blocks Receptor-mediated Functions*

G. M. Di Guglielmo, J. Bergeron, P. Brodt, 2001, The Journal of Biological Chemistry.

Mechanisms of neuroprotection against ischemic insult by stress‐inducible phosphoprotein‐1/prion protein complex

M. Caron, G. M. Di Guglielmo, Jue Fan, 2018, Journal of neurochemistry.

Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover.

J. Wrana, C. Le Roy, G. M. Di Guglielmo, 2003, Nature cell biology.

Spatial and Temporal Regulation of Receptor Tyrosine Kinase Activation and Intracellular Signal Transduction.

Sophie Dahan, G. M. Di Guglielmo, B. Posner, 2016, Annual review of biochemistry.

Canonical and Non-canonical TGFβ Signaling Activate Autophagy in an ULK1-Dependent Manner

G. M. Di Guglielmo, Charles B Trelford, Charles B. Trelford, 2021, Frontiers in Cell and Developmental Biology.

Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf‐1 by EGF but not insulin in liver parenchyma.

G. M. Di Guglielmo, B. Posner, J. Bergeron, 1994, The EMBO journal.

Insulin receptor internalization and signalling

Barry I. Posner, John J.M. Bergeron, G. M. Di Guglielmo, 1998, Molecular and Cellular Biochemistry.

The Synthetic Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid-Imidazolide Alters Transforming Growth Factor β-dependent Signaling and Cell Migration by Affecting the Cytoskeleton and the Polarity Complex*

M. Sporn, T. Pawson, J. Wrana, 2008, Journal of Biological Chemistry.

The acetylenic tricyclic bis(cyano enone), TBE-31, targets microtubule dynamics and cell polarity in migrating cells.

G. M. Di Guglielmo, T. Honda, Eddie Chan, 2016, Biochimica et biophysica acta.

Endoglin Null Endothelial Cells Proliferate Faster and Are More Responsive to Transforming Growth Factor β1 with Higher Affinity Receptors and an Activated Alk1 Pathway*

J. Wrana, E. Dejana, S. Liebner, 2005, Journal of Biological Chemistry.

Atypical Protein Kinase C Phosphorylates Par6 and Facilitates Transforming Growth Factor β-Induced Epithelial-to-Mesenchymal Transition

G. M. Di Guglielmo, B. Thai, A. Gunaratne, 2012, Molecular and Cellular Biology.

Par6 is phosphorylated by aPKC to facilitate EMT

G. M. Di Guglielmo, A. Gunaratne, 2013, Cell adhesion & migration.

β-Arrestin2 Regulates Lysophosphatidic Acid-Induced Human Breast Tumor Cell Migration and Invasion via Rap1 and IQGAP1

G. M. Di Guglielmo, D. Sacks, A. Babwah, 2013, PloS one.

GPR54 (KISS1R) Transactivates EGFR to Promote Breast Cancer Cell Invasiveness

G. M. Di Guglielmo, L. Postovit, A. Babwah, 2011, PloS one.

Synthetic Triterpenoids Target the Arp2/3 Complex and Inhibit Branched Actin Polymerization*

G. M. Di Guglielmo, B. Shilton, Ciric To, 2010, The Journal of Biological Chemistry.

The synthetic oleanane triterpenoid CDDO-Me binds and inhibits pyruvate kinase M2

E. Cino, I. N. Soares, G. M. Di Guglielmo, 2020, Pharmacological Reports.

βarrestin2 interacts with TβRII to regulate Smad-dependent and Smad-independent signal transduction.

G. M. Di Guglielmo, S. McLean, M. Bhattacharya, 2013, Cellular signalling.

The Acetylenic Tricyclic Bis(cyano enone), TBE-31 Inhibits Non–Small Cell Lung Cancer Cell Migration through Direct Binding with Actin

G. M. Di Guglielmo, T. Honda, Eddie Chan, 2014, Cancer Prevention Research.

TGFβ in endosomal signaling.

G. M. Di Guglielmo, S. McLean, 2014, Methods in enzymology.

Uptake and metabolic fate of [HisA8,HisB4,GluB10,HisB27]insulin in rat liver in vivo.

G. M. Di Guglielmo, J. Bergeron, G. Danielsen, 1998, The Biochemical journal.

Par6 is phosphorylated by aPKC to facilitate EMT

G. M. Di Guglielmo, A. Gunaratne, 2013, Cell adhesion & migration.

Acetylenic tricyclic bis-(cyano enone) interacts with Cys 374 of actin, a residue necessary for stress fiber formation and cell migration.

Brennan S. Dirk, G. M. Di Guglielmo, Eddie Chan, 2023, Biochimica et biophysica acta. Molecular cell research.

Expanding the Chemical Space of Transforming Growth Factor-β (TGFβ) Receptor Type II Degraders with 3,4-Disubstituted Indole Derivatives.

G. M. Di Guglielmo, F. Wesseler, D. Längle, 2024, ACS pharmacology & translational science.

Modulation of type II TGF-β receptor degradation by integrin-linked kinase.

G. M. Di Guglielmo, L. Dagnino, S. McLean, 2015, The Journal of investigative dermatology.