S. Geschwindner

发表

A protein tertiary structure mimetic modulator of the Hippo signalling pathway

Stéphanie M. Guéret, A. Plowright, Hacer Karatas, 2020, Nature Communications.

Ligand Binding Thermodynamics in Drug Discovery: Still a Hot Tip?

J. Ulander, S. Geschwindner, P. Johansson, 2015, Journal of medicinal chemistry.

Discovery of a novel warhead against beta-secretase through fragment-based lead generation.

Rutger H A Folmer, Stefan Geschwindner, S. Geschwindner, 2007, Journal of medicinal chemistry.

Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.

Victor Guallar, Christoph Grebner, Karl Edman, 2015, Structure.

Affinity-based, biophysical methods to detect and analyze ligand binding to recombinant proteins: matching high information content with high throughput.

Fredrik Edfeldt, Malcolm Anderson, Stefan Geschwindner, 2010, Journal of structural biology.

Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target

Christoph E. Dumelin, A. Keefe, R. Cooke, 2018, SLAS discovery : advancing life sciences R & D.

An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.

N. Blomberg, A. Breeze, S. Geschwindner, 2007, Current topics in medicinal chemistry.

Hot-Spotting with Thermal Scanning: A Ligand- and Structure-Independent Assessment of Target Ligandability.

S. Geschwindner, B. Clennell, F. Edfeldt, 2017, Journal of medicinal chemistry.

Preserved transmembrane protein mobility in polymer-supported lipid bilayers derived from cell membranes.

S. Geschwindner, F. Höök, A. Gunnarsson, 2015, Analytical chemistry.

Avidity-based affinity enhancement using nanoliposome-amplified SPR sensing enables low picomolar detection of biologically active Neuregulin 1.

M. Hölttä, S. Geschwindner, F. Höök, 2019, ACS sensors.

Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors.

Clay W Scott, S. Geschwindner, N. Dekker, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors.

Anna Aagaard, Stefan Geschwindner, Jenny Viklund, 2012, Bioorganic & medicinal chemistry letters.

Characterisation of de novo mutations in the C-terminal domain of proprotein convertase subtilisin/kexin type 9.

A. Plowright, S. Breuer, S. Geschwindner, 2015, Protein engineering, design & selection : PEDS.

Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7.

D. Brazil, Annika Urbanek, S. Geschwindner, 2015, The Biochemical journal.

Gremlin 1 preferentially binds to Bone Morphogenetic Protein

D. Brazil, Annika Urbanek, S. Geschwindner, 2014 .

Molecular architecture of potassium chloride co-transporter KCC2

N. Brandon, S. Moss, I. Medina, 2017, Scientific Reports.

Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion

U. Johansson, F. Jaisser, S. Geschwindner, 2018, PloS one.

Mining Natural Products for Macrocycles to Drug Difficult Targets

Vasanthanathan Poongavanam, J. Kihlberg, S. Geschwindner, 2020, Journal of medicinal chemistry.

Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: two bikes rather than a tandem.

S. Geschwindner, Yafeng Xue, R. Folmer, 2002, Biochemistry.

Perspectives on optical biosensor utility in small-molecule screening

S. Geschwindner, Tim Kaminski, 2017, Expert opinion on drug discovery.

Harnessing the Versatility of Optical Biosensors for Target-Based Small-Molecule Drug Discovery.

S. Geschwindner, A. Gunnarsson, Tim Kaminski, 2017, ACS sensors.

Label-Free Inhibition in Solution Assays for Fragment Screening

S. Geschwindner, 2015 .

Direct cell extraction of membrane proteins for structure–function analysis

S. Geschwindner, M. Radjainia, Jens Frauenfeld, 2022, bioRxiv.

Characterization of a Small Molecule Inhibitor of Plasminogen Activator Inhibitor Type 1 That Accelerates the Transition into the Latent Conformation*

S. Geschwindner, T. Sjögren, O. Fjellström, 2012, The Journal of Biological Chemistry.

Structural insight into allosteric modulation of protease-activated receptor 2

Patrik Johansson, Ali Jazayeri, Christoph Grebner, 2017, Nature.

Identification of structural-kinetic and structural-thermodynamic relationships for thrombin inhibitors.

Stefan Geschwindner, Djordje Musil, U Helena Danielson, 2013, Biochemistry.

Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency.

Gianni Chessari, Mark Sylvester, Rutger H A Folmer, 2007, Journal of medicinal chemistry.

Single-molecule biosensors: Recent advances and applications.

Fredrik Höök, Namik Akkilic, Stefan Geschwindner, 2020, Biosensors & bioelectronics.

Affinity‐Based Screening Methodologies and Their Application in the Hit‐to‐Lead Phase

S. Geschwindner, 2016 .

Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.

S. Geschwindner, Hui-Fang Chang, A. Llinàs, 2018, Journal of medicinal chemistry.

Role of calcium ions in the structure and function of the di-isopropylfluorophosphatase from Loligo vulgaris.

H. Rüterjans, S. Geschwindner, J. Hartleib, 2001, The Biochemical journal.

Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition

R. Cooke, D. Fairlie, S. Geschwindner, 2020, Communications biology.

The current impact of water thermodynamics for small-molecule drug discovery

J. Ulander, S. Geschwindner, 2019, Expert opinion on drug discovery.

Molecular architecture of potassium chloride co-transporter KCC2

N. Brandon, S. Moss, I. Medina, 2017, Scientific Reports.

Equilibrium-fluctuation analysis for interaction studies between natural ligands and single G protein-coupled receptors in native lipid vesicles.

S. Geschwindner, F. Höök, A. Gunnarsson, 2015, Langmuir : the ACS journal of surfaces and colloids.

Biophysical methods in drug discovery from small molecule to pharmaceutical.

Gareth Davies, Stefan Geschwindner, Nicola Colclough, 2013, Methods in molecular biology.

Novel Zn2+ Modulated GPR39 Receptor Agonists Do Not Drive Acute Insulin Secretion in Rodents

R. Isaacs, S. Geschwindner, L. Benthem, 2015, PloS one.

Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily

Patrik Johansson, Margareta Ek, Stefan Geschwindner, 2013, Proceedings of the National Academy of Sciences.

X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.

A. Nairn, N. Brandon, S. Geschwindner, 2017, Journal of medicinal chemistry.

Application of Optical Biosensors in Small-Molecule Screening Activities

Wolfgang Knecht, Stefan Geschwindner, Johan F. Carlsson, 2012, Sensors.

Affinity Capturing and Surface Enrichment of a Membrane Protein Embedded in a Continuous Supported Lipid Bilayer

S. Geschwindner, F. Höök, A. Gunnarsson, 2016, ChemistryOpen.

Drug discovery at the single molecule level: inhibition-in-solution assay of membrane-reconstituted β-secretase using single-molecule imaging.

S. Geschwindner, F. Höök, A. Gunnarsson, 2015, Analytical chemistry.

Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1–Nrf2 Protein–Protein Interaction

P. Matricon, R. Lewis, J. Kihlberg, 2022, Journal of medicinal chemistry.

Fragments as Novel Starting Points for tRNA‐Guanine Transglycosylase Inhibitors Found by Alternative Screening Strategies

G. Klebe, A. Heine, S. Geschwindner, 2019, ChemMedChem.

Regenerable Biosensors for Small-Molecule Kinetic Characterization Using SPR

V. Hytönen, S. Geschwindner, C. Stubbs, 2020, SLAS discovery : advancing life sciences R & D.

Biosensor-Enabled Deconvolution of the Avidity-Induced Affinity Enhancement for the SARS-CoV-2 Spike Protein and ACE2 Interaction

S. Geschwindner, T. Fornstedt, A. Gunnarsson, 2021, Analytical chemistry.

Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.

C. Grebner, V. Guallar, Magnus K. Bjursell, 2015, Structure.

Development of a plate-based optical biosensor fragment screening methodology to identify phosphodiesterase 10A inhibitors.

Clay W Scott, S. Geschwindner, R. Horsefield, 2013, Journal of medicinal chemistry.